CN110013780A - A kind of structure mixed using bubble - Google Patents
A kind of structure mixed using bubble Download PDFInfo
- Publication number
- CN110013780A CN110013780A CN201910291260.1A CN201910291260A CN110013780A CN 110013780 A CN110013780 A CN 110013780A CN 201910291260 A CN201910291260 A CN 201910291260A CN 110013780 A CN110013780 A CN 110013780A
- Authority
- CN
- China
- Prior art keywords
- room
- exhaust pipeline
- bubble
- liquid
- runner
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims description 19
- 239000004065 semiconductor Substances 0.000 claims description 4
- 230000005679 Peltier effect Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000001816 cooling Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/2319—Methods of introducing gases into liquid media
Abstract
The present invention relates to a kind of structures mixed using bubble, it includes the first Room, the second Room being connected with the first Room by syphon runner and the temperature-regulating module for adjusting temperature to second Room, syphon runner prevents the first indoor liquid from entering second Room, first Room is communicated with the atmosphere by first exhaust pipeline, the second Room is communicated with the atmosphere by second exhaust pipeline, and the flow resistance of the second exhaust pipeline is greater than the flow resistance of first exhaust pipeline；Two exhaust pipe flow resistances of the invention are different, when being heated to second Room, positioned at the second indoor air heats expansion, since second exhaust pipeline flow resistance is larger, most of gas can be discharged by syphon runner by the first Room, and bubble is generated in the liquid of the first Room, liquid is made to become disorder, to realize the effect of mixing.
Description
Technical field
The present invention relates to a kind of structures mixed using bubble.
Background technique
The reagent disc used in biology and medical science can disposably realize a variety of detection work to sample,
It in certain detection process, needs to mix two kinds of reagents, or sample is mixed with reagent, utilizes reagent certainly
Immixture may be implemented in the positive and negative rotation of disk, but under given conditions, reagent disc positive and negative rotation is likely to result in reagent
It flows, and is cannot be introduced into specified chamber to other directions, be not available this method at this time and mixed.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of structures mixed using bubble, can using the structure
To realize reagent disc without reversely rotating the operation that can realize liquid mixing.
The technical scheme adopted by the invention is that: a kind of structure mixed using bubble comprising the first Room, with the
The second Room that one Room is connected by syphon runner and the temperature-regulating module for adjusting temperature to second Room, syphon runner prevent
First indoor liquid enters second Room, and first Room is communicated with the atmosphere by first exhaust pipeline, and the second Room is logical
It crosses second exhaust pipeline to be communicated with the atmosphere, the flow resistance of the second exhaust pipeline is greater than the flow resistance of first exhaust pipeline.
Further, the syphon runner is inverted U shape, and the U-shaped bottom of the syphon runner is higher than the first indoor liquid level.
Further, the syphon runner is connected with the bottom of the first Room.
Further, the temperature-regulating module uses the semiconductor chilling plate using peltier effect.
Further, first Room, syphon runner and second Room are arranged on rotatable reagent disc, reagent disc by
Driving device driving rotation.
The positive effect of the present invention are as follows: two exhaust pipe flow resistances of the invention are different, when heating to second Room, are located at
Second indoor air heats expansion, since second exhaust pipeline flow resistance is larger, most of gas can be passed through by syphon runner
The discharge of first Room, and bubble is generated in the liquid of the first Room, so that liquid is become disorder, to realize the effect of mixing.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is schematic diagram of the present invention after the first indoor addition liquid；
Fig. 3 is schematic diagram of the present invention in the first indoor generation bubble.
Specific embodiment
As shown in Fig. 1, the present invention include the first Room 1, the second Room 3 being connected with the first Room 1 by syphon runner 2 with
And the temperature-regulating module 6 for heating up or cooling down to second Room 3, temperature-regulating module 6 can also heat whole device, effect phase
Together.The syphon runner 2 is inverted U shape, and U-shaped bottom is higher than the liquid level in the first Room 1, and one end is connected to the bottom end of the first Room 1.
After liquid to be mixed is added in the first Room 1, syphon runner 2 can prevent the liquid in the first Room 1 from flowing because of siphon principle
Enter to second Room 3, first Room 1 is communicated with the atmosphere by first exhaust pipeline 4, and the second Room 3 passes through second exhaust pipe
Road 5 is communicated with the atmosphere, and the flow resistance of second exhaust pipeline 5 is larger, and fluid resistance is 2 of fluid resistance in first exhaust pipeline 4
Times or more, preferably 3 times, so that the speed that gas is discharged from second exhaust pipeline 5 is small when the second indoor gas expansion
The fluid column in syphon runner 2 will be pushed into the first Room 1 in the gas of gas expansion speed in second Room, expansion, make
One Room 1 is connected to second Room 3, and the gas then expanded will form bubble discharge in the first Room 1, and bubble makes in the first Room 1
Liquid to become disorder unstable, so that liquid be made to mix.
The temperature-regulating module 6 may be implemented using the semiconductor chilling plate for utilizing peltier effect, the semiconductor chilling plate
The function of heat release and heat absorption can be heated or be cooled down to second Room 3.
First Room 1, syphon runner 2 and second Room 3 are arranged on rotatable reagent disc 7, and reagent disc 7 is by driving
Device driving rotation.Driving device can also be used using the conventional centrifugal rotor or CD/DVD driver of adjustable revolving speed
Other structures make the liquid on reagent disc 7 generate centrifugal force as long as the rotation of 7 positive and negative rotation of reagent disc may be implemented.
Use application method of the invention are as follows: firstly, liquid to be mixed is added in the first Room 1, according to U-tube original
Reason, can have part fluid column close to the side of the first Room 1 in siphon piping 2, as shown in Fig. 2.Then, temperature-regulating module pair is utilized
Second Room 3 is heated, and the temperature of second Room is increased, and is expanded in second indoor compressible medium the present embodiment for air,
Since the flow resistance of second exhaust pipeline 5 is larger, the speed that gas is discharged from second exhaust pipeline 5 is less than gas expansion in second Room
Fluid column in syphon runner 2 will be pushed into the first Room 1 by the gas of speed, expansion, and then gas is from first exhaust pipeline 4
Discharge, and bubble is generated in the first Room 1, as shown in figure 3, these bubbles can be used to carry out the liquid in the first Room 1
Mixing.Temperature-regulating module is located at the lower section of reagent disc 7, does not rotate together with reagent disc 7, and during heating, reagent disc 7 can revolve
Turn, can also be rotated with lower revolving speed, as revolving speed is lower than 10 revolutions per seconds.
It, can be then if the less liquid that can not make in the first Room 1 of bubble that the above operation generates is sufficiently mixed
It proceeds as follows.
Cooled down using temperature-regulating module to second Room 3, making the compressible medium in second Room 3 (is empty in the present embodiment
Gas) it shrinks, extraneous gas will be entered in second Room 3 by second exhaust pipeline 5, and compensation pressure is poor.To work as second Room 3
When heating up again, still there is gas that can expand generation bubble.Above-mentioned heating and cooling procedure are repeated, can be realized continuous
Bubble is generated in the first Room 1, mixes liquid adequately.
Since the flow resistance of second exhaust pipeline 5 is larger, the gas velocity that second Room 3 is supplemented when cooling down is slower, to siphon pipe
Liquid in road 2 can also generate the effect of vacuum suction, it is possible to the liquid in siphon piping 2 can be introduced into second Room 3.
Occur in order to prevent this phenomenon, can use driving device driving reagent disc 7 and rotate, revolving speed reaches 20 revolutions per seconds or more, makes the
Liquid in one Room 1 generates biggish centrifugal force, and under the influence of centrifugal force, the negative pressure that contraction of gas generates in second Room 3 is inhaled
Liquid in first Room 1 cannot be extracted into second Room 3 by gravitation, can only pass through 5 make-up gas of second exhaust pipeline.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to previous embodiment
Documented technical solution is modified or equivalent replacement of some of the technical features；And these are modified or replace
It changes, the spirit and scope for technical solution of the embodiment of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (5)
1. a kind of structure mixed using bubble, it is characterised in that it includes that the first room (1) and the first room (1) pass through rainbow
Inhale the second Room (3) that runner (2) are connected and the temperature-regulating module for adjusting temperature to second Room (3), syphon runner (2) resistance
Only the liquid in the first room (1) enters second Room (3), and first room (1) is connected by first exhaust pipeline (4) and atmosphere
Logical, the second Room (3) is communicated with the atmosphere by second exhaust pipeline (5), and the flow resistance of the second exhaust pipeline (5) is greater than the
The flow resistance of one exhaust pipe (4).
2. a kind of structure mixed using bubble according to claim 1, it is characterised in that the syphon runner (2)
It is inverted U shape, the U-shaped bottom of the syphon runner (2) is higher than the liquid level in the first room (1).
3. a kind of structure mixed using bubble according to claim 1 or 2, it is characterised in that the syphon runner
(2) it is connected with the bottom of the first room (1).
4. a kind of structure mixed using bubble according to claim 1, it is characterised in that the temperature-regulating module is adopted
With the semiconductor chilling plate using peltier effect.
5. a kind of structure mixed using bubble according to claim 1, it is characterised in that first room (1),
Syphon runner (2) and second Room (3) are arranged on rotatable reagent disc (7), and reagent disc (7) is driven by driving device to be revolved
Turn.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910291260.1A CN110013780A (en) | 2019-04-11 | 2019-04-11 | A kind of structure mixed using bubble |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910291260.1A CN110013780A (en) | 2019-04-11 | 2019-04-11 | A kind of structure mixed using bubble |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110013780A true CN110013780A (en) | 2019-07-16 |
Family
ID=67191126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910291260.1A Pending CN110013780A (en) | 2019-04-11 | 2019-04-11 | A kind of structure mixed using bubble |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110013780A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201429441Y (en) * | 2009-05-27 | 2010-03-24 | 厦门市建筑科学研究院集团股份有限公司 | Aluminium powder-evolved gas measurement apparatus |
| CN102419017A (en) * | 2011-09-09 | 2012-04-18 | 邵文远 | Breathing apparatus |
| DE102013203293A1 (en) * | 2013-02-27 | 2014-08-28 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidic device i.e. centrifugal disk, for e.g. automated bacteria-DNA-extraction from blood in laboratory, has outlet channels designed such that fluid is conducted via channel during expansion of compressed gas with expansion rate |
| US20160214105A1 (en) * | 2013-10-08 | 2016-07-28 | Hahn-Schickard-Gesellschaft Fuer Angewandte Forschung E.V. | Device and method for stirring at least one liquid |
| CN210674993U (en) * | 2019-04-11 | 2020-06-05 | 石家庄禾柏生物技术股份有限公司 | Structure for mixing by utilizing bubbles |
-
2019
- 2019-04-11 CN CN201910291260.1A patent/CN110013780A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201429441Y (en) * | 2009-05-27 | 2010-03-24 | 厦门市建筑科学研究院集团股份有限公司 | Aluminium powder-evolved gas measurement apparatus |
| CN102419017A (en) * | 2011-09-09 | 2012-04-18 | 邵文远 | Breathing apparatus |
| DE102013203293A1 (en) * | 2013-02-27 | 2014-08-28 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidic device i.e. centrifugal disk, for e.g. automated bacteria-DNA-extraction from blood in laboratory, has outlet channels designed such that fluid is conducted via channel during expansion of compressed gas with expansion rate |
| US20160214105A1 (en) * | 2013-10-08 | 2016-07-28 | Hahn-Schickard-Gesellschaft Fuer Angewandte Forschung E.V. | Device and method for stirring at least one liquid |
| CN210674993U (en) * | 2019-04-11 | 2020-06-05 | 石家庄禾柏生物技术股份有限公司 | Structure for mixing by utilizing bubbles |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10563656B2 (en) | Fluidics module, device and method for pumping a liquid | |
| CN106179549A (en) | A kind of micro-fluidic chip and application thereof | |
| JP3725834B2 (en) | Apparatus and method for using centripetal acceleration to drive flow motion in a microfluidic system | |
| CN111218395A (en) | Full-flow biological detection device | |
| JP2001503854A (en) | Capillary micro valve | |
| CN104588139B (en) | A kind of micro-fluidic chip and using method preparing microballoon | |
| US20140134631A1 (en) | Centrifugal microfluidic platform | |
| CN104155463B (en) | The device and method that a kind of microfluidic chip liquid drop produces and measures | |
| Hung et al. | An integrated microfluidic platform for rapid tumor cell isolation, counting and molecular diagnosis | |
| CN107876111A (en) | A kind of microlayer model generation chip and preparation method based on the driving of PDMS malleations | |
| CN104266516A (en) | Irregularly-shaped rotary heat pipe applicable to various rotation speeds | |
| CN107930868A (en) | A kind of supercentrifuge for food inspection | |
| CN110013780A (en) | A kind of structure mixed using bubble | |
| Gwak et al. | On-chip isolation and enrichment of circulating cell-free DNA using microfluidic device | |
| CN209974793U (en) | Digital PCR device and centrifugal microfluidic chip | |
| WO2024041209A1 (en) | Microfluidic chip | |
| CN210674993U (en) | Structure for mixing by utilizing bubbles | |
| US20060281192A1 (en) | Method for mixing fluids in microfluidic systems | |
| CN101748204B (en) | Nucleic acid hybridized platform based on micro-flow control and hybridization analysis method thereof | |
| CN110260026A (en) | Siphon valve arrangement and centrifugal microfluidic control device are assisted in air pressure | |
| Furukawa et al. | Nano-bubble valve | |
| Wu et al. | Fabrication of a 3D Teflon microdevice for energy free homogeneous liquid flow inside a long microchannel and its application to continuous-flow PCR | |
| JP2021090420A (en) | Nucleic acid-extracting apparatus | |
| Mamaev et al. | Rotary-based platform with disposable fluidic modules for automated isolation of nucleic acids | |
| Duanmu et al. | Research on the Device of Micro Droplet PCR in Microfluidic Chip Based on Constant Pressure Regulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |