CN110013438A - Polypeptide drug preparation facilities - Google Patents
Polypeptide drug preparation facilities Download PDFInfo
- Publication number
- CN110013438A CN110013438A CN201910319842.6A CN201910319842A CN110013438A CN 110013438 A CN110013438 A CN 110013438A CN 201910319842 A CN201910319842 A CN 201910319842A CN 110013438 A CN110013438 A CN 110013438A
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- wall
- block
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- axis
- sliding block
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Polypeptide drug preparation facilities, wherein, the polypeptide drug stuffing apparatus includes loading case, it is equipped in the filling case and loads chamber, the filling chamber front inner wall is equipped with opening (not shown), filling chamber top inner wall, which communicates to be equipped with, sets hopper, the hopper lower end of setting is communicated equipped with discharge nozzle, the filling is intracavitary to be provided with the uniform mixing device positioned at the discharge nozzle lower end, the discharge nozzle is equipped with valve group valence and is located at the uniform mixing device upper end, the filling chamber right end inner wall is provided with tripper and controls the valve member, wherein, the tripper controls the uniform mixing device；The configuration of the present invention is simple, ingredient load the quality for guaranteeing medicament after evenly mixing, while ensuring the weight of medicament using sealing structure, and mechanical automation production keeps away the self-contained harmful substance of operator and enters in drug.
Description
Technical field
The present invention relates to pharmaceutical production technical fields, specially polypeptide drug preparation facilities.
Background technique
Traditional pill production method processes complicated, some artificial costs to reduce purchase machine of medium-sized and small enterprises selection.
But since manually-operated subjective factor exists, every part of content of pill can be made not load accurately, while also not can guarantee
Environment clean level during filling generates infliction of body to eater.And the operation bring of artificial mechanism is straight
It is not high to connect productivity effect, product quality compliance rate is low.Therefore it is a can drug making apparatus under mechanization dustfree environment at
A kind of device that can solve the above problem illustrated for the inexorable trend of current pharmaceutical production industry development, the present invention.
Summary of the invention
The purpose of the present invention is to provide polypeptide drug preparation facilities, can overcome defect in the prior art.
Polypeptide drug preparation facilities according to the present invention, wherein the polypeptide drug stuffing apparatus includes loading case, the filling
It is equipped in case and loads chamber, the filling chamber front inner wall is equipped with opening (not shown), and filling chamber top inner wall, which communicates, to be equipped with
Hopper is set, the hopper lower end of setting is communicated equipped with discharge nozzle, described to load intracavitary be provided with positioned at the equal of the discharge nozzle lower end
Even mixing arrangement, the discharge nozzle are equipped with valve group valence and are located at the uniform mixing device upper end, the filling chamber right end
Inner wall is provided with tripper and controls the valve member, wherein the tripper fills the uniform mixing
It sets and is controlled, valve member part is controlled by the tripper and enters drug in the uniform mixing device, and
Amount of fill, which reaches, to be moved down power after certain value and is connected, and fillings bottom of chamber end inner wall is provided with medicine shell changeover module and described in being located at
Uniform mixing device lower end, the filling chamber right end inner wall are equipped with driven subassembly and are controlled by the medicine shell changeover module, wherein
The driven subassembly controls the uniform mixing device, is equipped in the driven subassembly and takes cap closing device and be located at institute
Medicine shell changeover module upper end is stated, described take is equipped with engagement jaw arrangement auxiliary grip, realizes that a medicine shell is corresponding in cap closing device
Polypeptide drug ingredient in the uniform pill of stirring structure of one anther cap closure linkage equipment.
It may be preferred that the uniform mixing device includes that filling chamber top inner wall is fixedly connected with suspension sliding block, institute
It states suspension sliding block and is equipped with the main lifting groove of opening to the left, the main lifting groove top inner wall is communicated equipped with horizontal slide, described
Main lifting groove right end inner wall is communicated equipped with hoistway, and the transmission that left and right extends is slidably connected on the hoistway
Axis, the transmission shaft right end are equipped with the abutting wheel being located on the outside of the suspension sliding block right part, and transmission shaft right end end is equipped with
Right coupling disc, the transmission shaft are equipped with closed half ball cover in a left side of right coupling disc right end, and the filling chamber left end inner wall is fixed to be connected
It is connected to driven sliding block, the driven sliding block is equipped with the secondary lifting groove of opening to the right, sliding connection in the pair lifting groove
There is the screw rod extended up and down, linkage frame is socketed on the discharge nozzle, the linkage outer frame side setting is useful sliding with the screw rod
The dynamic screw rod being cooperatively connected, the linkage upper slide of frame are connected to symmetrical closed sliding block, closed sliding block described in right end with it is described
It is rotatably assorted between transmission shaft and connection and is located at the closed half ball cover right end in left side, the remote symmetrical centre side of the closed sliding block and pair
The side press close to each other of lifting groove, main lifting groove is connected with reset spring, is rotatably assorted and is connected on closed sliding block described in left end
The fixed point axis that left and right extends, the fixed point axis are equipped with the left coupling disc for the connection that offsets with the right coupling disc, the fixed point
Axis is equipped with the temporary collecting box positioned at the left coupling disc left end, and the fixed point axis, which is equipped with, is located at the temporary collecting box left side
Closed half ball cover in a left side at end is fixedly connected with the material-collecting tube positioned at the temporary collecting box lower end in the driven sliding block.
It may be preferred that the valve member includes that driven sliding block upper end end face is fixedly connected with chassis, the chassis
On be rotatably assorted and be connected with rotating plate, press is connected with torque spring (not shown), institute between the chassis on rear side of the rotating plate
The chute hole (not marking) that rotating plate is equipped with front and back perforation is stated, the gear that left and right extends is slidably connected on the discharge nozzle
Door, the gear door are equipped with the port being connected with the discharge nozzle, and the gear door with chute hole equipped with (not being schemed
Show) sliding fixed tip (not marking).
It may be preferred that the tripper includes that the filling chamber right end inner wall is fixedly connected with motor, the motor is left
End end is connected by power the power input shaft that left and right extends, and is threadedly engaged to be connected on the power input shaft and moves horizontally
Block, the block lower end that moves horizontally are slidably connected with auxiliary hanger, are fixedly connected on the left of the auxiliary hanger vertical end
Interlocking bar, the auxiliary hanger horizontal ends are rotatably assorted the thread spindle for being connected with and extending up and down, the thread spindle and the lifting
Connection is threadedly engaged between ring, thread spindle upper end end is equipped with lifting bevel gear, is slidably matched on the power input shaft
Connect the useful linkage bevel gear with the lifting ratcheting connection of bevel gear, the linkage bevel gear and the power input shaft it
Between connected by spline, pressed on the left of the linkage bevel gear with the suspension sliding block right side and be connected with torsion spring, it is described
It is equipped on the right side of dynamic bevel gear with the concave ring groove for the connection that offsets with the interlocking bar.
It may be preferred that the medicine shell changeover module includes being rotatably assorted to be connected in the filling bottom of chamber end to extend up and down
Gap axis, the gap axis are equipped with four angular poles, and four angular pole is equipped with the bearing frame positioned at the material-collecting tube lower end, described
Gap axis, which is equipped with, obtains sheave positioned at four angular pole lower end, and filling bottom of chamber end inner wall is embedded with positioned at the gap axis
The motor of right end, motor upper end end are connected by power the drive shaft extended up and down, and the drive shaft, which is equipped with, to be used
Offset the thumb wheel of connection with the sheave, and the drive shaft is equipped with the driving gear positioned at the thumb wheel lower end.
It may be preferred that the driven subassembly includes that filling bottom of chamber end inner wall is rotatably assorted and is connected with positioned at the driving
Axis right end and the driven shaft extended up and down, the driven shaft are equipped with the driven gear with the ratcheting connection of the driving gear,
The driven shaft is equipped with longitudinal bevel gear positioned at the driven gear upper end, and the filling chamber right end inner wall is rotatably assorted company
It is connected to the turning axis that left and right extends, the turning axis is equipped with the lateral bevel gear with longitudinal ratcheting connection of bevel gear,
The turning axis is equipped with the bottom pulley for being located at the lateral bevel gear right end, and the filling chamber right end inner wall is rotatably assorted company
It is connected to the rotation axis that positioned at the turning axis upper end and left and right extends, the rotation axis, which is equipped with, is located at the bottom pulley upper end
Idler, the rotation axis is equipped with the cam of idler left end, and the filling chamber right end inner wall is rotatably assorted
It is connected with the epithelium tape spool that positioned at the rotation axis upper end and left and right extends, the epithelium tape spool, which is equipped with, is located at the tensioning skin
The upper belt pulley of belt wheel upper end has been connected by power skin between the upper belt pulley, the idler and the bottom pulley
Band, the epithelium tape spool are equipped with the driving lever being located in the upper belt pulley left end, and the driving lever abuts phase between wheel with described
To connection.
It may be preferred that it is described take cap closing device include it is described load it is intracavitary be slidably connected with with the cam phase
Right angle deflecting plate to connection, press is connected with horizontal drawing between the right angle deflecting plate front side and the filling chamber front inner wall
Spring is stretched, press is connected with lifting extension spring between the right angle deflecting plate upside and filling chamber top inner wall, described
The pressing jaw being fixedly connected on the upside of the bearing frame on the downside of right angle deflecting plate, the right angle deflecting plate downside are fixedly connected
There is the engagement jaw arrangement positioned at the pressing jaw front end, the filling chamber front inner wall is fixedly connected with to be filled positioned at the meshing pawl
The clevis block of lower end is set, is slidably connected with block step by step in the clevis block, on the downside of the block step by step and in the clevis block
Side press is connected with compressed spring.
It may be preferred that the engagement jaw arrangement includes that reaction block is fixedly connected on the downside of the right angle deflecting plate, it is described anti-
It answers and is equipped with reaction chamber in block, the reaction chamber front inner wall is slidably connected with the abutting bar that left and right extends, the abutting bar
Rear side with it is described react between cavity wall press and be connected with only stop spring, be equipped in the reaction chamber and be located at described abutting bar or so
Hold switching shaft that is symmetrical and extending up and down, the switching shaft be equipped with with the driven sliding block for abutting the ratcheting connection of bar,
The reaction chamber front inner wall is slidably connected with the push rod positioned at the switching shaft far from symmetrical centre side, the reaction block
Front end surface is fixedly connected with symmetrical swing arm, is slidably connected in the swing arm from moving slide-bar, the driven cunning
Bar is equipped with the driven pushing block for the connection that offsets with the push rod, and described be equipped with from moving slide-bar is located at the swing arm far from symmetrical
The limit plate of central side, the limit plate and swing arm side press close to each other are connected with limit spring, described from moving slide-bar
It is upper that pawl is auxiliarily fixed close to symmetrical centre side positioned at the driven pushing block.
The beneficial effects of the present invention are: structure of the invention is simple, and it is easy to operate, guarantee drug by analogy sealed environment
The environmental sanitation produced, and the high efficiency of the powder manufacture of the whole function realization device using mechanization linkage, and it is real
The medicament of existing accurate measurement loads the subjective factor for avoiding loading worker.It is realized again by the structure of spherical clips mixing equal
Even mixed polypeptide medicine particle ingredient.When ensuring the distribution of polypeptide drug non-uniform components in the form of closed ball cover, Bu Huiyin
It reveals to rock and causes the not up to standard of polypeptide drug weight ratio.By elasticity and can restore structure realize equipment be used for multiple times,
The corresponding a medicine shell cap of a medicine shell realizes that single-shot loads.
Detailed description of the invention
The present invention is described in detail by following specific embodiments and drawings for ease of explanation,.
Fig. 1 for polypeptide drug preparation facilities institute use device of the invention overall structure diagram；
Fig. 2 is the cross section structure schematic diagram of " A-A " of Fig. 1；
Fig. 3 is the cross section structure schematic diagram of " B-B " of Fig. 1；
Fig. 4 is the enlarged structure schematic diagram of " C " of Fig. 1.
Specific embodiment
Below with reference to Fig. 1-Fig. 4, the present invention is described in detail, for sake of convenience, now provides to hereafter described orientation
As follows: hereafter described front-rear direction up and down is consistent with the front-rear direction up and down of Fig. 1 projection relation itself.
Polypeptide drug preparation facilities according to the present invention, wherein the polypeptide drug stuffing apparatus includes loading case 10, described to fill out
10 interior are equipped with of casing load chamber 11, and 11 front inner wall of filling chamber, which is equipped with, to be open (not shown), in 11 top of filling chamber
Wall, which communicates to be equipped with, sets hopper 54, and 54 lower end of hopper of setting is communicated equipped with discharge nozzle 55, is provided with and is located in the filling chamber 11
The uniform mixing device of 55 lower end of discharge nozzle, the discharge nozzle 55 are equipped with valve group valence and are located at the uniform mixing dress
Upper end is set, the 11 right end inner wall of filling chamber is provided with tripper and controls the valve member, wherein the solution
Locking device controls the uniform mixing device, is controlled by the tripper valve member part drug entering institute
It states in uniform mixing device, and moves down power after amount of fill reaches certain value and be connected, 11 bottom end inner wall of the filling chamber setting
Have medicine shell changeover module and be located at the uniform mixing device lower end, the 11 right end inner wall of fillings chamber equipped with driven subassembly and by
The medicine shell changeover module control, wherein the driven subassembly controls the uniform mixing device, the driven subassembly
Interior be equipped with takes cap closing device and is located at the medicine shell changeover module upper end, and described take is equipped with engagement jaw arrangement in cap closing device
Auxiliary grip realizes the polypeptide drug in the uniform pill of stirring structure of the corresponding anther cap closure linkage equipment of a medicine shell
Ingredient.
Valuably, the uniform mixing device includes that the 11 top inner wall of filling chamber is fixedly connected with suspension sliding block 14,
The suspension sliding block 14 is equipped with the main lifting groove 15 of opening to the left, and it is sliding that the main 15 top inner wall of lifting groove communicates the level of being equipped with
Road 59, the main 15 right end inner wall of lifting groove are communicated equipped with hoistway 16, are slidably connected on the hoistway 16
The transmission shaft 18 that left and right extends, 18 right end of transmission shaft are equipped with the abutting wheel 17 being located on the outside of suspension 14 right part of sliding block,
The 18 right end end of transmission shaft is equipped with right coupling disc 41, and the transmission shaft 18 is equipped with a left side closed half for right 41 right end of coupling disc
Ball cover 88, the 11 left end inner wall of filling chamber are fixedly connected with driven sliding block 39, and the driven sliding block 39 is equipped with opening to the right
Secondary lifting groove 50, it is described pair lifting groove 50 in be slidably connected with the screw rod 49 extended up and down, covered on the discharge nozzle 55
It is connected to linkage frame 48, the useful screw rod 49 with the screw rod 49 sliding connection is set on the outside of the linkage frame 48, it is described
Slipping on dynamic frame 48 has symmetrical closed sliding block 47, rotates and matches between closed sliding block 47 and the transmission shaft 18 described in right end
Conjunction connects and is located at closed half ball cover, 88 right end in the left side, the remote symmetrical centre side of the closed sliding block 47 and secondary lifting groove 50, master
The press of the side close to each other of lifting groove 15 is connected with reset spring 46, is rotatably assorted on closed sliding block 47 described in left end and is connected with left and right
The fixed point axis 45 of extension, the fixed point axis 45 is equipped with the left coupling disc 44 with the connection that offsets with the right coupling disc 41, described
It pinpoints axis 45 and is equipped with the temporary collecting box 43 for being located at left 44 left end of coupling disc, the fixed point axis 45 is equipped with positioned at described
Closed half ball cover 42 in a left side of temporary 43 left end of collecting box is fixedly connected with positioned at the temporary collecting box in the driven sliding block 39
The material-collecting tube 40 of 43 lower ends.
Valuably, the valve member includes that the 39 upper end end face of driven sliding block is fixedly connected with chassis 51, the bottom
It is rotatably assorted on frame 51 and is connected with rotating plate 52, press is connected with torque spring between 52 rear side of rotating plate and the chassis 51
(not shown), the rotating plate 52 are equipped with the chute hole (not marking) of front and back perforation, are slidably connected on the discharge nozzle 55
The gear door 53 for having left and right to extend, the gear door 53 are equipped with the port 56 being connected with the discharge nozzle 55, the gear door
53 be equipped with with chute hole sliding fixed tip (not marking) (not shown).
Valuably, the tripper includes that the 11 right end inner wall of filling chamber is fixedly connected with motor 58, the motor
58 left ends end are connected by power the power input shaft 57 that left and right extends, and are threadedly engaged on the power input shaft 57 and are connected with water
Motion block 84 is translated, 84 lower end of block that moves horizontally is slidably connected with auxiliary hanger 86,86 vertical end of auxiliary hanger
Left side is fixedly connected with interlocking bar 85, and auxiliary 86 horizontal ends of hanger are rotatably assorted the thread spindle 12 for being connected with and extending up and down,
Connection is threadedly engaged between the thread spindle 12 and the lifting ring 13, the 12 upper end end of thread spindle is equipped with lifting bevel gear
87, it is slidably connected on the power input shaft 57 with the linkage bevel gear with the lifting ratcheting connection of bevel gear 87
82, connected between the linkage bevel gear 82 and the power input shaft 57 by spline, 82 left side of the linkage bevel gear and
Press is connected with torsion spring 81 on the right side of the suspension sliding block 14, on the right side of the linkage bevel gear 82 equipped with with the interlocking bar
85 concave ring grooves 83 for offseting connection.
Valuably, the medicine shell changeover module includes being rotatably assorted to be connected in 11 bottom end of the filling chamber to extend up and down
Gap axis 35, the gap axis 35 are equipped with four angular poles 37, and four angular pole 37 is equipped with positioned at 40 lower end of material-collecting tube
Bearing frame 38, the gap axis 35, which is equipped with, to be located at four angular poles, 37 lower end and obtains sheave 36, in 11 bottom end of filling chamber
Wall is embedded with the motor 32 positioned at 35 right end of gap axis, and 32 upper end end of the motor has been connected by power extension up and down
Drive shaft 33, the drive shaft 33 is equipped with the thumb wheel 34 of the connection that offsets with the sheave 36, sets in the drive shaft 33
There is the driving gear 31 positioned at 34 lower end of thumb wheel.
Valuably, the driven subassembly includes that the 11 bottom end inner wall of filling chamber is rotatably assorted and is connected with positioned at the driving
33 right end of axis and the driven shaft 29 extended up and down, the driven shaft 29 be equipped with with the driving gear 31 ratcheting connection from
Moving gear 28, the driven shaft 29 are equipped with longitudinal bevel gear 30 positioned at 28 upper end of driven gear, the filling chamber 11
Right end inner wall, which is rotatably assorted, is connected with the turning axis 27 that left and right extends, the turning axis 27 be equipped with with longitudinal bevel gear
The lateral bevel gear 25 of 30 ratcheting connections, the turning axis 27 are equipped with the bottom pulley for being located at 25 right end of the lateral bevel gear
26, the filling 11 right end inner wall of chamber, which is rotatably assorted, to be connected with positioned at 27 upper end of turning axis and controls the rotation axis extended
24, the rotation axis 24 is equipped with the idler 23 positioned at 26 upper end of bottom pulley, and the rotation axis 24 is equipped with
The cam 67 of 23 left end of idler, the 11 right end inner wall of filling chamber, which is rotatably assorted, to be connected in the rotation axis 24
The epithelium tape spool 20 that end and left and right extend, the epithelium tape spool 20 are equipped with the upper belt positioned at 23 upper end of idler
Wheel 19, has been connected by power belt 22 between the upper belt pulley 19, the idler 23 and the bottom pulley 26, described
Epithelium tape spool 20 is equipped with the driving lever 21 being located in 19 left end of upper belt pulley, and the driving lever 21 abuts between wheel 17 with described
Offset connection.
Valuably, it is described take cap closing device include be slidably connected in the filling chamber 11 with the cam 67
Offset the right angle deflecting plate 66 of connection, press connection between 66 front side of right angle deflecting plate and 11 front inner wall of fillings chamber
There is horizontal stretch spring 61, press is connected with lifting between 66 upside of right angle deflecting plate and the 11 top inner wall of filling chamber
Extension spring 60 is fixedly connected with the pressing jaw 65 positioned at 38 upside of bearing frame on the downside of the right angle deflecting plate 66, described
The engagement jaw arrangement positioned at 65 front end of pressing jaw is fixedly connected on the downside of right angle deflecting plate 66, in 11 front end of the filling chamber
Wall is fixedly connected with the clevis block 62 positioned at the engagement jaw arrangement lower end, is slidably connected with step by step in the clevis block 62
Block 64,64 downside of block step by step are connected with compressed spring 63 with press on the inside of the clevis block 62.
Valuably, the engagement jaw arrangement includes being fixedly connected with reaction block 72 on the downside of the right angle deflecting plate 66, described
Reaction chamber 73 is equipped in reaction block 72,73 front inner wall of reaction chamber is slidably connected with the abutting bar 70 that left and right extends,
Press, which is connected with, between 70 rear side of abutting bar and 73 inner wall of the reaction chamber only stops spring 71, is equipped in the reaction chamber 73
Switching shaft 68 that is symmetrical and extending up and down is held positioned at the abutting bar 70 or so, the switching shaft 68 is equipped with and is supported with described
The driven sliding block 39 of the ratcheting connection of extension bar 70,73 front inner wall of reaction chamber are slidably connected with positioned at the switching shaft 68
Push rod 74 far from symmetrical centre side, 72 front end surface of reaction block are fixedly connected with symmetrical swing arm 75, the pendulum
Be slidably connected on arm 75 from moving slide-bar 78, it is described from moving slide-bar 78 be equipped with with the push rod 74 offset connection from
Dynamic pushing block 79, described be equipped with from moving slide-bar 78 are located at limit plate 76 of the swing arm 75 far from symmetrical centre side, the limit
Plate 76 and the press of the swing arm 75 side close to each other are connected with limit spring 77, described to be located at described driven push away from moving slide-bar 78
Pawl 80 is auxiliarily fixed close to symmetrical centre side in block 79.
Apparatus of the present invention course of work is as described below:
In the initial state, engagement jaw arrangement is located at 62 upper end of clevis block to a kind of polypeptide drug stuffing apparatus of the invention, and presses
Claw 65 is located at 38 upper end of right side bearing frame, by the good original polypeptide powder of quantitative proportioning down to setting in hopper 54, motor 58, electricity
The closing of motivation 32 makes all parts be in off working state.
When being worked using a kind of polypeptide drug stuffing apparatus of the invention, starter motor 58 rotates power input shaft 57
And moved to left by being threadedly coupled to make to move horizontally block 84, it moves horizontally block 84 and pushes gear door 53 to move to left by auxiliary hanger 86, and
Port 56 is moved in discharge nozzle 55 and is got through, gear door 53, which moves to left, keeps fixed tip (not marking) and chute hole (not shown) sliding
Torque spring savings power potential energy (not shown) is rotated and makes, simultaneously because interlocking bar 85 pushes linkage bevel gear 82 to synchronize a left side
Move, guarantee linkage bevel gear 82 and go up and down bevel gear 87 between ratcheting connection do not depart from implementation transmission, linkage bevel gear 82 by
Going up and down bevel gear 87 by ratcheting connection in spline rotation moves down mixing arrangement, abuts abutting wheel 17 with upper belt pulley 19,
And bevel gear 82 of linking rotation makes torsion spring 81 put aside power potential energy, and thread spindle 12 makes under lifting ring 13 by threaded connection
It moves, lifting ring 13, which moves down to move down by the frame 48 that links, makes close to each other between closed sliding block 47, closed sliding block 47 shifting close to each other
It moves to move towards with transmission shaft 18 by respective fixed point axis 45 and left coupling disc 44 is made to offset with right coupling disc 41 and connect, Zuo Lian
Reel 44 offsets with right coupling disc 41 and connect rotation, and left closed half ball cover 88 offsets with left closed half ball cover 42 and connect, Qian Zhedong
Power connects the latter's sealing and prevents from revealing, counter to unwind locking device and move up uniform mixing device, and is restored by 46 elasticity of reset spring
Ability can restore initial position, polypeptide drug by material-collecting tube 40 fall on the medicine shell in bearing frame 38 it is a certain amount of after starting it is electronic
32 rotate driving axis 33 of machine drives driven subassembly by driving gear 31, stirs four every time by the abutting of thumb wheel 34 and sheave 36
/ mono- circle, sheave 36 makes four angular poles 37 synchronous rotation exchange the medicine shell filled and do not loaded with this by gap axis 35, driven
Gear 28 and the ratcheting connection of driving gear 31 rotation pass through driven shaft 29 and longitudinal bevel gear 30 are driven to rotate, and longitudinal bevel gear 30 is logical
It crosses ratcheting connection and rotates lateral bevel gear 25, lateral bevel gear 25 rotates bottom pulley 26, bottom pulley 26 by turning axis 27
Idler 23 and upper belt pulley 19 is driven to rotate by belt 22, idler 23 is by rotation axis 24 with moving cam
67, make to take cap closing device to work, upper belt pulley 19 rotates driving lever 21 by epithelium tape spool 20, and have the relationship of abutting make to
Cock wheel 17 rotates uniform mixing device, and anti-motor 58 of opening by the above process abuts abutting wheel 17 with the disengaging of upper belt pulley 19,
Medicine shell cap is deposited in clevis block 62, and by pressing, block 64 makes compressed spring 63 put aside power potential energy and discharges monomer step by step step by step,
The rotation quadrant of cam 67 first pushes right angle deflecting plate 66 to advance through engagement jaw arrangement crawl medicine shell cap and moves forward to undertaking
On the upside of frame 38, the Forward of right angle deflecting plate 66 makes abutting bar 70 abut the interior sliding of promotion abutting 70 casees reaction chambers of bar 73 with medicine shell cap simultaneously
Make only to stop the savings power potential energy of spring 71, abuts bar 70 by ratcheting connection and rotate change gear 69, move forward push rod 74
And driven pushing block 79 is pushed, driven pushing block 79 makes mobile from moving slide-bar 78 to symmetrical centre side and makes limit spring 77 by abutting
Power potential energy is put aside, auxiliary clamp medicine shell cap is rotated further by a quarter bowlder and pushes since 61 elasticity of horizontal stretch spring is restored
And move down right angle deflecting plate 66 and be closed pill by pressing jaw 65, it is taken out by extraneous manipulator from opening is (not shown)
Dress packet.
The beneficial effects of the present invention are: structure of the invention is simple, and it is easy to operate, guarantee drug by analogy sealed environment
The environmental sanitation produced, and the high efficiency of the powder manufacture of the whole function realization device using mechanization linkage, and it is real
The medicament of existing accurate measurement loads the subjective factor for avoiding loading worker.It is realized again by the structure of spherical clips mixing equal
Even mixed polypeptide medicine particle ingredient.When ensuring the distribution of polypeptide drug non-uniform components in the form of closed ball cover, Bu Huiyin
It reveals to rock and causes the not up to standard of polypeptide drug weight ratio.By elasticity and can restore structure realize equipment be used for multiple times,
The corresponding a medicine shell cap of a medicine shell realizes that single-shot loads.
In the above manner, those skilled in the art can be made within the scope of the invention according to operating mode it is various
Change.
Claims (8)
1. polypeptide drug preparation facilities, wherein the polypeptide drug stuffing apparatus includes loading case, is equipped with and loads in the filling case
Chamber, the filling chamber front inner wall are equipped with opening (not shown), and filling chamber top inner wall, which communicates to be equipped with, sets hopper, described to set
Hopper lower end is communicated equipped with discharge nozzle, and the filling is intracavitary to be provided with the uniform mixing device positioned at the discharge nozzle lower end, institute
Discharge nozzle is stated equipped with valve group valence and is located at the uniform mixing device upper end, the filling chamber right end inner wall is provided with unlock
Device and the valve member is controlled, wherein the tripper controls the uniform mixing device, passes through
The tripper, which controls valve member part, enters drug in the uniform mixing device, and reaches certain value in amount of fill
After move down power and be connected, fillings bottom of chamber end inner wall is provided with medicine shell changeover module and under the uniform mixing device
End, the filling chamber right end inner wall are equipped with driven subassembly and are controlled by the medicine shell changeover module, wherein the driven subassembly pair
The uniform mixing device is controlled, and is equipped in the driven subassembly and is taken cap closing device and be located at the medicine shell changeover module
Upper end, described take are equipped with engagement jaw arrangement auxiliary grip in cap closing device, realize the corresponding anther cap closure of a medicine shell simultaneously
Polypeptide drug ingredient in the uniform pill of the stirring structure of interlocking equipment.
2. polypeptide drug preparation facilities as described in claim 1, it is characterised in that: the uniform mixing device includes described fills out
Top inner wall of behaveing affectedly is fixedly connected with suspension sliding block, and the suspension sliding block is equipped with the main lifting groove of opening to the left, the main liter
Drop groove top end inner wall is communicated equipped with horizontal slide, and the main lifting groove right end inner wall is communicated equipped with hoistway, and the lifting is slided
The transmission shaft that left and right extends is slidably connected on road, the transmission shaft right end, which is equipped with, to be located on the outside of the suspension sliding block right part
Abutting wheel, transmission shaft right end end be equipped with right coupling disc, the transmission shaft be equipped with right coupling disc right end a left side it is closed
Half ball cover, filling chamber left end inner wall are fixedly connected with driven sliding block, and the driven sliding block is equipped with the secondary liter of opening to the right
Slot is dropped, the screw rod extended up and down is slidably connected in the pair lifting groove, linkage frame is socketed on the discharge nozzle, it is described
The useful screw rod with screw rod sliding connection is arranged in linkage outer frame side, and the linkage upper slide of frame is connected to symmetrical close
Sliding block is closed, being rotatably assorted between closed sliding block and the transmission shaft described in right end, it is right to connect and be located at closed half ball cover in the left side
End, the closed remote symmetrical centre side of sliding block and secondary lifting groove, main lifting groove side close to each other press and are connected with reset spring, left
Hold be rotatably assorted on the closed sliding block be connected with left and right extend fixed point axis, the fixed point axis equipped with with the right connecting shaft
Disk offsets the left coupling disc of connection, and the fixed point axis is equipped with the temporary collecting box positioned at the left coupling disc left end, described fixed
Point axis is equipped with closed half ball cover in a left side positioned at the temporary collecting box left end, is fixedly connected in the driven sliding block positioned at institute
State the material-collecting tube of temporary collecting box lower end.
3. polypeptide drug preparation facilities as described in claim 1, it is characterised in that: the valve member includes the driven cunning
Block upper end end face is fixedly connected with chassis, is rotatably assorted on the chassis and is connected with rotating plate, the rotating plate rear side and the chassis
Between press and be connected with torque spring (not shown), the rotating plate is equipped with the chute hole (not marking) of front and back perforation, it is described go out
The gear door that left and right extends is slidably connected in expects pipe, the gear door is equipped with logical with being connected with the discharge nozzle
Mouthful, the gear door be equipped with with chute hole sliding fixed tip (not marking) (not shown).
4. polypeptide drug preparation facilities as described in claim 1, it is characterised in that: the tripper includes the filling chamber
Right end inner wall is fixedly connected with motor, and motor left end end is connected by power the power input shaft that left and right extends, described dynamic
It being threadedly engaged to be connected on power input shaft and moves horizontally block, the block lower end that moves horizontally is slidably connected with auxiliary hanger,
Be fixedly connected with interlocking bar on the left of the auxiliary hanger vertical end, the auxiliary hanger horizontal ends be rotatably assorted be connected with it is downward
The thread spindle stretched, is threadedly engaged connection between the thread spindle and the lifting ring, thread spindle upper end end is equipped with lifting
Bevel gear is slidably connected on the power input shaft with the linkage bevel gear with the lifting ratcheting connection of bevel gear,
It connects between the linkage bevel gear and the power input shaft by spline, is slided on the left of the linkage bevel gear with the suspension
Press is connected with torsion spring on the right side of block, is equipped on the right side of the linkage bevel gear with the concave ring for the connection that offsets with the interlocking bar
Slot.
5. polypeptide drug preparation facilities as described in claim 1, it is characterised in that: the medicine shell changeover module includes described fills out
It behave affectedly in bottom end the gap axis for being connected with and extending up and down that is rotatably assorted, the gap axis is equipped with four angular poles, on four angular pole
Equipped with the bearing frame for being located at the material-collecting tube lower end, the gap axis, which is equipped with, obtains sheave positioned at four angular pole lower end, institute
It states filling bottom of chamber end inner wall and is embedded with the motor positioned at the gap axis right end, motor upper end end has been connected by power
The drive shaft extended up and down, the drive shaft are equipped with the thumb wheel for the connection that offsets with the sheave, and the drive shaft is equipped with
Driving gear positioned at the thumb wheel lower end.
6. polypeptide drug preparation facilities as described in claim 1, it is characterised in that: the driven subassembly includes the filling chamber
Bottom end inner wall is rotatably assorted the driven shaft for being connected with positioned at the drive shaft right end and extending up and down, and the driven shaft, which is equipped with, to be used
With the driven gear of the ratcheting connection of the driving gear, the driven shaft is equipped with longitudinal cone positioned at the driven gear upper end
Gear, it is described load chamber right end inner wall be rotatably assorted is connected with left and right extend turning axis, the turning axis be equipped with with institute
The lateral bevel gear of the ratcheting connection of longitudinal bevel gear is stated, the turning axis is equipped with the hypodermis for being located at the lateral bevel gear right end
Belt wheel, the filling chamber right end inner wall, which is rotatably assorted, to be connected with positioned at the turning axis upper end and controls the rotation axis extended, institute
It states rotation axis and is equipped with the idler for being located at the bottom pulley upper end, the rotation axis is equipped with idler left end
Cam, it is described load chamber right end inner wall be rotatably assorted is connected with positioned at the rotation axis upper end and left and right extend upper belt
Axis, the epithelium tape spool are equipped with the upper belt pulley positioned at the idler upper end, the upper belt pulley, the tensioning skin
Belt is connected by power between belt wheel and the bottom pulley, the epithelium tape spool, which is equipped with, to be located in the upper belt pulley left end
Driving lever, the driving lever offsets connection between wheel with described abut.
7. polypeptide drug preparation facilities as described in claim 1 or 6, it is characterised in that: described to take cap closing device include institute
State load it is intracavitary be slidably connected with the right angle deflecting plate for the connection that offsets with the cam, on front side of the right angle deflecting plate with
Press is connected with horizontal stretch spring, the right angle deflecting plate upside and the filling chamber top between the filling chamber front inner wall
Press is connected with lifting extension spring between the inner wall of end, is fixedly connected on the bearing frame on the downside of the right angle deflecting plate
The pressing jaw of side, the right angle deflecting plate downside is fixedly connected with the engagement jaw arrangement positioned at the pressing jaw front end, described to fill out
Front inner wall of behaveing affectedly is fixedly connected with the clevis block positioned at the engagement jaw arrangement lower end, sliding connection in the clevis block
There is block step by step, is pressed on the downside of the block step by step with the clevis block inside and be connected with compressed spring.
8. polypeptide drug preparation facilities as claimed in claim 7, it is characterised in that: the engagement jaw arrangement includes the right angle
It is fixedly connected with reaction block on the downside of deflecting plate, is equipped with reaction chamber in the reaction block, the reaction chamber front inner wall is slidably matched
Be connected with the abutting bar that left and right extends, on rear side of the abuttings bar with it is described react to press to be connected between cavity wall only stop spring,
The switching shaft for being located at that the abutting bar or so end is symmetrical and extends up and down is equipped in the reaction chamber, the switching shaft is equipped with
With with the driven sliding block for abutting the ratcheting connection of bar, the reaction chamber front inner wall is slidably connected with positioned at the switching
Push rod of the axis far from symmetrical centre side, the reaction block front end surface are fixedly connected with symmetrical swing arm, in the swing arm
It is slidably connected with from moving slide-bar, it is described to be equipped with from moving slide-bar with the driven pushing block for the connection that offsets with the push rod, it is described
It is equipped with from moving slide-bar and is located at limit plate of the swing arm far from symmetrical centre side, the limit plate and the swing arm are close to each other
Side press is connected with limit spring, described upper in driven pushing block being auxiliarily fixed close to symmetrical centre side from moving slide-bar
Pawl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910319842.6A CN110013438A (en) | 2019-04-19 | 2019-04-19 | Polypeptide drug preparation facilities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910319842.6A CN110013438A (en) | 2019-04-19 | 2019-04-19 | Polypeptide drug preparation facilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110013438A true CN110013438A (en) | 2019-07-16 |
Family
ID=67191993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910319842.6A Withdrawn CN110013438A (en) | 2019-04-19 | 2019-04-19 | Polypeptide drug preparation facilities |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110013438A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110308611A (en) * | 2019-07-22 | 2019-10-08 | 义乌纹挺新能源科技有限公司 | A kind of projector automatic focusing device |
| CN110485224A (en) * | 2019-08-13 | 2019-11-22 | 宣化钢铁集团有限责任公司 | A kind of ash pillow bolt vibration positioning device |
| CN112870078A (en) * | 2021-01-15 | 2021-06-01 | 赵寒英 | Tablet shredding and feeding device for pediatrics |
-
2019
- 2019-04-19 CN CN201910319842.6A patent/CN110013438A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110308611A (en) * | 2019-07-22 | 2019-10-08 | 义乌纹挺新能源科技有限公司 | A kind of projector automatic focusing device |
| CN110308611B (en) * | 2019-07-22 | 2021-01-26 | 山东万恒电子通讯设备有限公司 | Automatic focusing device of projector |
| CN110485224A (en) * | 2019-08-13 | 2019-11-22 | 宣化钢铁集团有限责任公司 | A kind of ash pillow bolt vibration positioning device |
| CN112870078A (en) * | 2021-01-15 | 2021-06-01 | 赵寒英 | Tablet shredding and feeding device for pediatrics |
| CN112870078B (en) * | 2021-01-15 | 2023-09-01 | 南京茂升德科技有限公司 | Tablet shredding and feeding device for pediatrics |
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Application publication date: 20190716 |