CN1100097A - Apiolin-A use in preparation of medicine for prevention and treatment of diseases caused by cerebral ischemia - Google Patents
Apiolin-A use in preparation of medicine for prevention and treatment of diseases caused by cerebral ischemia Download PDFInfo
- Publication number
- CN1100097A CN1100097A CN 93117148 CN93117148A CN1100097A CN 1100097 A CN1100097 A CN 1100097A CN 93117148 CN93117148 CN 93117148 CN 93117148 A CN93117148 A CN 93117148A CN 1100097 A CN1100097 A CN 1100097A
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- butylphthalide
- application
- medicine
- cerebral
- mammals
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Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN93117148A CN1048158C (en) | 1993-09-09 | 1993-09-09 | Apiolin-A use in preparation of medicine for prevention and treatment of diseases caused by cerebral ischemia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN93117148A CN1048158C (en) | 1993-09-09 | 1993-09-09 | Apiolin-A use in preparation of medicine for prevention and treatment of diseases caused by cerebral ischemia |
Publications (2)
Publication Number | Publication Date |
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CN1100097A true CN1100097A (en) | 1995-03-15 |
CN1048158C CN1048158C (en) | 2000-01-12 |
Family
ID=4991882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN93117148A Expired - Lifetime CN1048158C (en) | 1993-09-09 | 1993-09-09 | Apiolin-A use in preparation of medicine for prevention and treatment of diseases caused by cerebral ischemia |
Country Status (1)
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CN (1) | CN1048158C (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005002568A1 (en) * | 2003-06-20 | 2005-01-13 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthlide in preventing and treating dementia |
WO2005034936A1 (en) * | 2003-10-10 | 2005-04-21 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct |
WO2005072725A1 (en) * | 2004-01-20 | 2005-08-11 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The use of l-butylphthalide in the manufacturing of medicines for the prevention and treatment of cerebral ischemia disease |
WO2006021160A1 (en) | 2004-08-27 | 2006-03-02 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application |
WO2007068212A1 (en) * | 2005-12-16 | 2007-06-21 | Shijiazhuang Pharma Group Nbp Pharmaceutical Co., Ltd. | Intravenous emulsion of butylbenzene phthalein and its application |
JP2008502607A (en) * | 2004-06-18 | 2008-01-31 | 石薬集団中奇制薬技術(石家庄)有限公司 | Application of Ln-butylphthalide in prevention and treatment of dementia |
CN100435792C (en) * | 2004-04-23 | 2008-11-26 | 石药集团中奇制药技术(石家庄)有限公司 | Application of butylbenzene phthalein homolog in preparation of medicine for treating cerebral ischemia disease |
US7678776B2 (en) | 2002-08-21 | 2010-03-16 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof |
CN102178643A (en) * | 2011-04-29 | 2011-09-14 | 石药集团恩必普药业有限公司 | Microemulsion transdermal gel agent of butylphthalide or derivative thereof, and preparation method thereof |
CN101289438B (en) * | 2007-04-16 | 2012-04-18 | 山东绿叶天然药物研究开发有限公司 | 3-(3'-hydroxyl)-butyl phthalide ester, and preparation thereof and uses |
TWI419686B (en) * | 2004-10-29 | 2013-12-21 | Inst Materia Medica Cams | The use of therapeutic and preventive action of l-3-n-butylphthalide on dementia, involving alzheimer's disease and vascular dementia |
CN105130934A (en) * | 2015-08-15 | 2015-12-09 | 石药集团恩必普药业有限公司 | Butyl phthalide raw material drug product and preparation method thereof |
CN106963757A (en) * | 2012-04-01 | 2017-07-21 | 石药集团恩必普药业有限公司 | Application of the butylphenyl phthaleine or derivatives thereof in the medicine for preparing therapeutic radiation brain damage |
WO2018209973A1 (en) * | 2017-05-19 | 2018-11-22 | 泰州华元医药科技有限公司 | Brain damage resistance deuterated compounds and medical use thereof |
CN109419800A (en) * | 2017-08-30 | 2019-03-05 | 石药集团恩必普药业有限公司 | Pharmaceutical composition and its application |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5598169A (en) * | 1979-01-23 | 1980-07-25 | Masayuki Ishikawa | Preparation of 1-phthalazone derivative having aromatic residue substituent at 2-position |
-
1993
- 1993-09-09 CN CN93117148A patent/CN1048158C/en not_active Expired - Lifetime
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7678776B2 (en) | 2002-08-21 | 2010-03-16 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof |
WO2005002568A1 (en) * | 2003-06-20 | 2005-01-13 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The application of l-n-butylphthlide in preventing and treating dementia |
JP2014205724A (en) * | 2003-10-10 | 2014-10-30 | シジャージョアン ファーマ. グループ ジョオンチ ファーマシューティカル テクノロジー(シジャージョアン)カンパニー リミテッド | Use of l-butylphthalide in manufacture of medicament for prevention and treatment of cerebral infarction |
EP2974722A1 (en) * | 2003-10-10 | 2016-01-20 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct |
JP2007507436A (en) * | 2003-10-10 | 2007-03-29 | シジャージョアン ファーマ. グループ ジョオンチ ファーマシューティカル テクノロジー(シジャージョアン)カンパニー リミテッド | Use of L-butylphthalide in the manufacture of pharmaceuticals for the prevention and treatment of cerebral infarction |
CN102008464B (en) * | 2003-10-10 | 2012-08-29 | 石药集团中奇制药技术(石家庄)有限公司 | Application of levobutyl phthalide in preparation of medicament for preventing and treating cerebral infarction |
WO2005034936A1 (en) * | 2003-10-10 | 2005-04-21 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct |
AU2004279655B2 (en) * | 2003-10-10 | 2008-09-25 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct |
US8598225B2 (en) | 2003-10-10 | 2013-12-03 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Use of L-butylphthalide in the manufacture of medicaments for treatment of cerebral infarct |
EP2689776A1 (en) * | 2003-10-10 | 2014-01-29 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct |
JP2011116781A (en) * | 2003-10-10 | 2011-06-16 | Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co Ltd | Use of l-butylphthalide in manufacture of medicament for prevention and treatment of cerebral infarction |
WO2005072725A1 (en) * | 2004-01-20 | 2005-08-11 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The use of l-butylphthalide in the manufacturing of medicines for the prevention and treatment of cerebral ischemia disease |
US9795585B2 (en) | 2004-01-20 | 2017-10-24 | CSPC Zhongqi Pharmaceutical Technology (Shijizhuang) Co. Ltd. | Methods of using L-butylphthalide for the prevention and treatment of cerebral ischemia disease |
EP2682117A1 (en) * | 2004-01-20 | 2014-01-08 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | The use of L-butylphthalide in the manufacturing of medicines for the prevention and treatment of cerebral ischemia disease |
CN100435792C (en) * | 2004-04-23 | 2008-11-26 | 石药集团中奇制药技术(石家庄)有限公司 | Application of butylbenzene phthalein homolog in preparation of medicine for treating cerebral ischemia disease |
US8552058B2 (en) | 2004-06-18 | 2013-10-08 | CSPC Zhongqi Pharmaceutical Technology (Shijazhuang) Co., Ltd. | Application of L-n-butylphthalide in preventing and treating dementia |
JP2008502607A (en) * | 2004-06-18 | 2008-01-31 | 石薬集団中奇制薬技術(石家庄)有限公司 | Application of Ln-butylphthalide in prevention and treatment of dementia |
WO2006021160A1 (en) | 2004-08-27 | 2006-03-02 | Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application |
EP1787638A4 (en) * | 2004-08-27 | 2008-12-03 | Shijiazhuang Pharma Group | Butylbenzene phthalein self-emulsifying drug delivery system, its preparation method and application |
US8728518B2 (en) | 2004-08-27 | 2014-05-20 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd | Butylphthalide self-emulsifying drug delivery system, its preparation and method and application |
TWI419686B (en) * | 2004-10-29 | 2013-12-21 | Inst Materia Medica Cams | The use of therapeutic and preventive action of l-3-n-butylphthalide on dementia, involving alzheimer's disease and vascular dementia |
AU2006324219B2 (en) * | 2005-12-16 | 2010-03-04 | Cspc Nbp Pharmaceutical Co. Ltd. | Butylphthalide intravenous emulsion and application thereof |
EA014518B1 (en) * | 2005-12-16 | 2010-12-30 | СиЭсПиСи ЭнБиПи ФАРМАСЬЮТИКЛ КО., ЛТД. | Emulsion of butylphthalide for intravenous administration and its application |
US10463614B2 (en) | 2005-12-16 | 2019-11-05 | Shijiazhuang Pharma Group Nbp Pharmaceutical Co. | Butylphthalide intravenous emulsion and application thereof |
WO2007068212A1 (en) * | 2005-12-16 | 2007-06-21 | Shijiazhuang Pharma Group Nbp Pharmaceutical Co., Ltd. | Intravenous emulsion of butylbenzene phthalein and its application |
CN101289438B (en) * | 2007-04-16 | 2012-04-18 | 山东绿叶天然药物研究开发有限公司 | 3-(3'-hydroxyl)-butyl phthalide ester, and preparation thereof and uses |
CN102178643B (en) * | 2011-04-29 | 2014-05-14 | 石药集团恩必普药业有限公司 | Microemulsion transdermal gel agent of butylphthalide or derivative thereof, and preparation method thereof |
CN102178643A (en) * | 2011-04-29 | 2011-09-14 | 石药集团恩必普药业有限公司 | Microemulsion transdermal gel agent of butylphthalide or derivative thereof, and preparation method thereof |
CN106963757A (en) * | 2012-04-01 | 2017-07-21 | 石药集团恩必普药业有限公司 | Application of the butylphenyl phthaleine or derivatives thereof in the medicine for preparing therapeutic radiation brain damage |
CN105130934A (en) * | 2015-08-15 | 2015-12-09 | 石药集团恩必普药业有限公司 | Butyl phthalide raw material drug product and preparation method thereof |
CN105130934B (en) * | 2015-08-15 | 2018-11-23 | 石药集团恩必普药业有限公司 | A kind of butylphenyl phthaleine bulk pharmaceutical chemicals product and preparation method thereof |
WO2018209973A1 (en) * | 2017-05-19 | 2018-11-22 | 泰州华元医药科技有限公司 | Brain damage resistance deuterated compounds and medical use thereof |
CN109419800A (en) * | 2017-08-30 | 2019-03-05 | 石药集团恩必普药业有限公司 | Pharmaceutical composition and its application |
CN109419800B (en) * | 2017-08-30 | 2021-04-30 | 石药集团恩必普药业有限公司 | Pharmaceutical composition and application thereof |
Also Published As
Publication number | Publication date |
---|---|
CN1048158C (en) | 2000-01-12 |
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Owner name: TU & P PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: NONE Effective date: 20041210 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20041210 Address after: 100050 Beijing Xiannongtan Street No. 1 Co-applicant after: Grace General Pharmaceutical Co., Ltd. Patentee after: Institute of Materia Medica of Chinese Academy of Medical Sciences Address before: 100050 Beijing Xiannongtan Street No. 1 Patentee before: Institute of Materia Medica of Chinese Academy of Medical Sciences |
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C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: 100050 Beijing Xiannongtan Street No. 1 Co-patentee after: Enbipu Pharmacy Co., Ltd., Shiyao Group. Patentee after: Institute of Materia Medica of Chinese Academy of Medical Sciences Address before: 100050 Beijing Xiannongtan Street No. 1 Co-patentee before: Grace General Pharmaceutical Co., Ltd. Patentee before: Institute of Materia Medica of Chinese Academy of Medical Sciences |
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C17 | Cessation of patent right | ||
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Expiration termination date: 20130909 Granted publication date: 20000112 |