CN109999348A - A method of transcranial magnetic stimulation deep brain area is realized based on diffusion tensor - Google Patents
A method of transcranial magnetic stimulation deep brain area is realized based on diffusion tensor Download PDFInfo
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- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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Abstract
The invention discloses a kind of methods for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor comprising following steps: obtaining the brain structure of transcranial magnetic stimulation subject to be subjected as information and diffusion tensor information；The deep brain area coordinate of transcranial magnetic stimulation subject to be subjected is determined based on diffusion tensor technology；The white matter structure connection features of deep brain area and full brain based on diffusion tensor information architecture transcranial magnetic stimulation subject to be subjected, there are the cortex brain areas that white matter structure is connect with deep brain area for extraction；Based on there are the best cortex position coordinates that the cortex brain area that white matter structure is connect determines transcranial magnetic stimulation subject to be subjected with deep brain area；By navigation positioning system, using best cortex position coordinates as the direct intervention site of conventional stimulating coil, the placing direction that guidance stimulating coil is moved towards with the white matter fiber connection in white matter structure connection features, realizes cerebral magnetic stimulation coil to accurate, the Individual treatment of deep brain area.
Description
Technical field
The present invention relates to the methods that a kind of pair of deep brain area realizes transcranial magnetic stimulation, are based especially on diffusion tensor pair
Deep brain area implements individuation, the method for accurate transcranial magnetic stimulation.
Background technique
Transcranial magnetic stimulation is noninvasive neuromodulation technology outside a kind of cranium, by applying electromagnetic field, magnetic field penetration cranium outside cranium
Bone generates induction field in cerebral cortex, neuron can be promoted to depolarize, and plays excited or inhibitory effect, changes localized cerebral
Plasticity.1985, Barker and its partner had developed First modern times transcranial magnetic stimulation instrument in Sheffield, GBR,
Transcranial magnetic stimulation technology is applied to the basic research and Cognitive Study of volume infarct cerebral first later.It is subsequently found, specific mould
Influence of the transcranial magnetic stimulation of formula to brain activity still has in certain time after stimulation, and transcranial magnetic stimulation is controlled
Treatment acts on the clinical treatment to have been gone through at present by public concern applied to depressive disorder, also have largely schizophrenia,
Clinical Evidence in the spirit such as Parkinson, pain and neurogenic disease.Transcranial magnetic stimulation technology has noninvasive, safety
Good, Small side effects a little, have important clinical value and demand.
Transcranial magnetic stimulation intervenes position, is the key parameter for influencing Neural stem cell effect and clinical efficacy.Routine magnetic thorn at present
Coil (by taking splayed coil as an example) is swashed up to 2-3cm under coil, the most deep reachable 4-6cm of newest H-type magnetic stimulating coil, Neural stem cell
Useful effect position is mainly or positioned at cortex.Therefore, existing magnetic stimulating coil presence can not useful effect cerebral deep position
Bottleneck.And it is located at the subcortical structure, such as cingulum, hippocampus, amygdaloid nucleus, corpus straitum etc. of cerebral deep, it is mood and cognition
Key position in nerve pathway, it is closely related with the pathogenesis of a variety of spirit and neurogenic disease.Existing transcranial magnetic stimulation
Technology cannot achieve the effective prevention to cerebral deep structure, limits the range of brain plasticity research, also constrains the skill
The curative effect of art in clinical treatment, limits clinical application and popularization.
Summary of the invention
The present invention is in view of the problems of the existing technology and insufficient, provides one kind and is realized based on diffusion tensor through cranium magnetic
The method for stimulating deep brain area, this method exist most by diffusion tensor technology, building with the intervention target spot for being located at deep
The cortex position of strong white matter structure connection, the intervention position as conventional magnetic stimulating coil；Guidance is moved towards based on white matter fiber tract
The placing direction of stimulating coil realizes accurate, Individual treatment to deep brain area.
The present invention is to solve above-mentioned technical problem by following technical proposals:
The present invention provides a kind of method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor, and feature exists
In comprising following steps:
S1, the brain structure of transcranial magnetic stimulation subject to be subjected is obtained as information and diffusion tensor information；
S2, the deep brain area coordinate that transcranial magnetic stimulation subject to be subjected is determined based on diffusion tensor technology；
The white matter of S3, the deep brain area based on diffusion tensor information architecture transcranial magnetic stimulation subject to be subjected and full brain
Structure connection features, there are the cortex brain areas that white matter structure is connect with deep brain area for extraction；
S4, based on there are the cortex brain areas that white matter structure is connect to determine transcranial magnetic stimulation to be subjected subject with deep brain area
Best cortex position coordinates；
S5, by navigation positioning system, using best cortex position coordinates as the direct intervention site of conventional stimulating coil,
The placing direction that guidance stimulating coil is moved towards with the white matter fiber connection in white matter structure connection features, realizes transcranial magnetic stimulation line
Enclose accurate, the Individual treatment to deep brain area.
Preferably, in step sl, brain structure includes monomer element or multi-voxel proton as information, and brain structure is as information source
In the magnetic resonance configurations picture of transcranial magnetic stimulation to be subjected subject or disclosed normal structure as image.
Preferably, step S2 the following steps are included:
S21, establish obtain brain structure as between information and diffusion tensor information mapping and transforming relationship；
S22, the deep brain area coordinate that transcranial magnetic stimulation subject to be subjected is determined on diffusion tensor image.
Preferably, step S3 the following steps are included:
S31, according on diffusion tensor image determine deep brain area coordinate can using white matter fiber track algorithm
But it is not limited to calculate the white matter of deep brain area coordinate and all voxels of full brain using track algorithm or probabilistic tracking algorithm etc. is determined
Structure connection features value；
There are the cortex brain areas that white matter structure connects for S32, extraction and deep brain area, candidate's stimulation as transcranial magnetic stimulation
Position.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can any combination to get each preferable reality of the present invention
Example.
The positive effect of the present invention is that:
1) defect of deep brain area can not be acted on for existing Neural stem cell intervention, the technical program be based on dispersion tensor at
As the Neural stem cell intervention to deep brain area, the effective prevention range for expanding and extending Neural stem cell to brain may be implemented.
2) compared to existing Use of Neuronavigation localization method, the technical program not only provides accurate cortex and intervenes site, and
And move towards to determine the intervention direction of transcranial magnetic stimulation according to individual white matter fiber, further improve the accuracy of positioning.
3) this method is achieved that by conventional cerebral magnetic stimulation coil, compatible with existing hardware, will greatly improve equipment
Using effect and application range, benefit basic research and clinical application.
Detailed description of the invention
Fig. 1 is the method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor of present pre-ferred embodiments
Flow chart.
Fig. 2 implements magnetic thorn to deep brain area (hippocampus) based on what diffusion tensor was realized for present pre-ferred embodiments
Sharp flow chart.
Fig. 3 implements magnetic thorn to deep brain area (hippocampus) based on what diffusion tensor was realized for present pre-ferred embodiments
Sharp effect picture.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art
Every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
As shown in Figure 1, the present embodiment provides a kind of sides for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor
Method comprising following steps:
Step 1: obtaining the brain structure of transcranial magnetic stimulation subject to be subjected as information and diffusion tensor information.
In step 1, brain structure is as information includes monomer element or multi-voxel proton, and brain structure is as information is to be subjected
The magnetic resonance configurations picture or disclosed normal structure of transcranial magnetic stimulation subject are as image.
Step 2: the deep brain area coordinate of transcranial magnetic stimulation subject to be subjected is determined based on diffusion tensor technology.
Step 2.1: establish the brain structure of acquisition as between information and diffusion tensor information mapping and transforming relationship.
Step 2.2: the deep brain area coordinate of transcranial magnetic stimulation subject to be subjected is determined on diffusion tensor image.
Step 3: deep brain area and full brain based on diffusion tensor information architecture transcranial magnetic stimulation subject to be subjected
White matter structure connection features, there are the cortex brain areas that white matter structure is connect with deep brain area for extraction.
Step 31: according to the deep brain area coordinate determined on diffusion tensor image, using white matter fiber track algorithm,
It can but be not limited to using determining track algorithm or probabilistic tracking algorithm etc., calculating deep brain area coordinate is white with all voxels of full brain
Matter structure connection features value.
Step 32: there are the cortex brain areas that white matter structure is connect with deep brain area for extraction, the candidate as transcranial magnetic stimulation
Stimulation sites.
Step 4: based on there are the cortex brain areas that white matter structure is connect to determine transcranial magnetic stimulation quilt to be subjected with deep brain area
The best cortex position coordinates of examination.
Step 5: by navigation positioning system, using best cortex position coordinates as the direct intervention position of conventional stimulating coil
Point, the placing direction of guidance stimulating coil is moved towards with the white matter fiber connection in white matter structure connection features, and realization is pierced through cranium magnetic
Coil is swashed to accurate, the Individual treatment of deep brain area.
Based on the principle of the above-mentioned method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor, one is named
Specific example illustrates the present invention, so that those skilled in the art better understood when technical solution of the present invention:
For the present embodiment using deep brain area hippocampus as embodiment, specific implementation step is as shown in Figure 2, comprising:
Step 1: acquisition obtains the magnetic resonance configurations picture (sMRI) and diffusion tensor of transcranial magnetic stimulation subject to be subjected
(DTI) image.
Step 2.1: after sMRI and DTI image is carried out conventional pretreatment, being registrated, between the generation space sMRI and DTI
Mapping, transitional information.
Step 2.2: the sMRI image based on transcranial magnetic stimulation to be subjected subject determines that the deep brain area position with stimulation is made
For region of interest (ROI).ROI selects according to actual needs, monomer element or multi-voxel proton ROI to can be used.ROI is selected in the present embodiment
Subcortical structure left hippocampus positioned at deep includes multi-voxel proton, and the method for generating left hippocampus template is from Harvard-
Oxford template extraction, as shown in (a) in Fig. 3.
Step 2.3: generating the region of interest template in the space DTI.According to (the individual sMRI of space locating for region of interest template
Space or standard form space) implement conversion.In the present embodiment, left hippocampus template is derived from normed space, needs to complete standard
The conversion in space to the individual space DTI generates the ROI template in the individual space DTI, as shown in (b) in Fig. 3.
Step 3: with the ROI template in the space DTI, being based on white matter fiber track algorithm, acquisition region of interest is white with full brain
Matter structure connection figure.To be tested the left hippocampus template in the space DTI as seed point in the present embodiment, left hippocampus and complete is obtained
The white matter structure connection figure of brain, as shown in (c) in Fig. 3.
Step 4: being determined as conventional magnetic stimulating coil direct intervention according to position and with the function connects intensity of ROI
Best site.In the present embodiment, in the white matter function connects figure of left hippocampus and full brain that step 3 obtains, most preferably intervene position
Point is left side top, as shown in (d) cross coordinate in Fig. 3.
Step 5: by navigation positioning system, using cortex site as the direct intervention site of conventional stimulating coil, white matter
The placing direction of guidance stimulating coil is moved towards in fiber connection, realizes conventional magnetic stimulating coil to accurate, the individuation of deep brain area
Intervene.
The present invention is based on the white matters between diffusion tensor building cerebral deep structure (> 5cm) and superficial cortex (2-3cm)
Structure connection figure；Superficial cortex site is directly acted on by magnetic stimulating coil, realizes indirectly-acting in the effect of DEEP STRUCTURE.
The position in superficial direct intervention site is not only accurately positioned in this method, and can precisely be controlled according to white matter fiber trend
The placing direction of magnetic stimulating coil processed, realize precisely, individuation this Neural stem cell intervention.
Although specific embodiments of the present invention have been described above, it will be appreciated by those of skill in the art that these
It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back
Under the premise of from the principle and substance of the present invention, many changes and modifications may be made, but these are changed
Protection scope of the present invention is each fallen with modification.
Claims (5)
1. a kind of method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor, which is characterized in that it includes following
Step:
S1, the brain structure of transcranial magnetic stimulation subject to be subjected is obtained as information and diffusion tensor information；
S2, the deep brain area coordinate that transcranial magnetic stimulation subject to be subjected is determined based on diffusion tensor technology；
The white matter structure of S3, the deep brain area based on diffusion tensor information architecture transcranial magnetic stimulation subject to be subjected and full brain
Connection features, there are the cortex brain areas that white matter structure is connect with deep brain area for extraction；
S4, based on there are the cortex brain areas that white matter structure is connect to determine the best of transcranial magnetic stimulation to be subjected subject with deep brain area
Cortex position coordinates；
S5, by navigation positioning system, using best cortex position coordinates as the direct intervention site of conventional stimulating coil, with white
The placing direction of guidance stimulating coil is moved towards in white matter fiber connection in matter structure connection features, realizes cerebral magnetic stimulation coil pair
Accurate, the Individual treatment of deep brain area.
2. the method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor as described in claim 1, feature exist
In in step sl, brain structure includes monomer element or multi-voxel proton as information, and brain structure is as information is to be subjected through cranium
The magnetic resonance configurations picture or disclosed normal structure of Neural stem cell subject are as image.
3. the method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor as described in claim 1, feature exist
In, step S2 the following steps are included:
S21, establish obtain brain structure as between information and diffusion tensor information mapping and transforming relationship；
S22, the deep brain area coordinate that transcranial magnetic stimulation subject to be subjected is determined on diffusion tensor image.
4. the method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor as claimed in claim 3, feature exist
In, step S3 the following steps are included:
S31, it is calculated deep according to the deep brain area coordinate determined on diffusion tensor image using white matter fiber track algorithm
The white matter structure connection features value of portion's brain area coordinate and all voxels of full brain；
There are the cortex brain areas that white matter structure connects for S32, extraction and deep brain area, the candidate stimulation position as transcranial magnetic stimulation
It sets.
5. the method for realizing transcranial magnetic stimulation deep brain area based on diffusion tensor as claimed in claim 4, feature exist
In white matter fiber track algorithm is using determining track algorithm or probabilistic tracking algorithm.
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| CN110477917A (en) * | 2019-08-13 | 2019-11-22 | 深圳先进技术研究院 | Intracerebral lymphatic vessel stimulating system, method and control device |
| CN111249622A (en) * | 2020-01-17 | 2020-06-09 | 上海市精神卫生中心（上海市心理咨询培训中心） | Accurate transcranial magnetic stimulation online navigation method based on augmented reality |
| CN114463493A (en) * | 2022-01-18 | 2022-05-10 | 武汉工程大学 | Transcranial magnetic stimulation electric field rapid imaging method and model based on coding and decoding structure |
| CN115995299A (en) * | 2023-03-22 | 2023-04-21 | 北京航空航天大学 | Method, system, electronic equipment and medium for positioning individual regulation and control targets |
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