CN109994189B - Display method and device of digital pathological section and computer equipment - Google Patents
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Abstract
The embodiment of the invention discloses a method and a device for displaying a digital pathological section and computer equipment, wherein the method comprises the following steps: acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. By the aid of the method, the risk of missed diagnosis and misdiagnosis of diseases can be reduced to a certain extent.
Description
Technical Field
The invention relates to the technical field of pathological diagnosis, in particular to a method and a device for displaying digital pathological sections and computer equipment.
Background
Pathological diagnosis refers to the confirmation of a disease by a doctor under a microscope by observing the enlarged cells of a surgically excised specimen. Digital pathology means that a doctor determines a disease according to a high-resolution digital pathological section, and specifically, the doctor diagnoses the disease through two-dimensional image observation displayed on a display end of a terminal device.
In the existing digital pathological section scanner, a digital pathological section is obtained through an optical amplification system and a high-pixel scanning and image-taking system, and then a disease is diagnosed at a display end. Such a disease diagnosis method can bring great convenience to doctors, and doctors no longer need to conduct accurate disease diagnosis with a microscope.
However, the digital pathological section obtained by the digital pathological section scanner is only a single picture of one focus layer, there is a great difference between observing such a picture and observing the pathological section directly through a microscope, and the diagnosis of a disease by observing a single picture of one focus layer is more complicated than the diagnosis of a disease by directly observing the pathological section through a microscope because of much lost information, increasing the risk of missed diagnosis and misdiagnosis.
Disclosure of Invention
In view of the above, there is a need to provide a method, an apparatus and a computer device for displaying digital pathological sections, which can reduce the risks of missed diagnosis and misdiagnosis.
A method of displaying a digital pathology slice, the method comprising:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
acquiring the definition of each region focusing image in each region pathological image set;
and selecting a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
In one embodiment, after the acquiring the sharpness of the focus image of each region in each region pathology image set, the method further includes:
sequencing the definition of each region focusing image in each region pathological image set to obtain a sequencing result of the definition of each region focusing image;
the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps:
and selecting a region focusing image with the highest definition from the unselected images in each region pathological image set for splicing according to the sequencing result of the definition of each region focusing image in the region pathological image set.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generating and displaying of the pathological section cartoon image according to the plurality of pathological section panoramic images comprises:
and generating and displaying a pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
In one embodiment, the generating a pathological section animation image from the plurality of pathological section panoramic images includes:
scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image;
determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image;
and generating a pathological section cartoon image according to the display duration of each pathological section panoramic image.
In one embodiment, the determining, according to the scoring result of each of the pathological section panoramic images, the display duration of the corresponding pathological section panoramic image includes:
and acquiring a corresponding relation table of the score and the display duration, and determining the display duration of the corresponding pathological section panoramic image according to the score result of each pathological section panoramic image and the corresponding relation table, wherein the score and the display duration in the corresponding relation table are in inverse correlation.
A display device of a digital pathological section, comprising:
the acquisition module is used for acquiring a regional pathological image set corresponding to each subregion of the pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
the splicing module is used for selecting a region focusing image from each region pathological image set to splice to obtain a pathological section panoramic image of the pathological section;
and the generation module is used for acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
In one embodiment, the splicing module includes:
the definition acquisition module is used for acquiring the definition of each region focusing image in each region pathological image set;
and the definition splicing module is used for selecting one region focusing image from each region pathological image set to splice according to the definition of each region focusing image in the region pathological image sets.
In one embodiment, the apparatus further comprises:
the definition sorting module is used for sorting the definition of each region focusing image in each region pathological image set to obtain a sorting result of the definition of each region focusing image;
the definition stitching module comprises: and the highest-definition splicing module is used for selecting a region focusing image with highest definition from the unselected images in each region pathological image set according to the sequencing result of the definition of each region focusing image in the region pathological image set and splicing the selected region focusing images.
In one embodiment, the splicing module includes:
the same focusing layer splicing module is used for respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generation module comprises: and the same focusing layer generation module is used for generating and displaying the pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
In one embodiment, the generating module includes:
the scoring module is used for scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image;
the duration determining module is used for determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image;
and the duration generation module is used for generating a pathological section animation image according to the display duration of each pathological section panoramic image.
In one embodiment, the duration determining module includes:
and the time length anti-correlation module is used for acquiring a corresponding relation table of the score and the display time length, determining the display time length of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image and the corresponding relation table, and the score and the display time length in the corresponding relation table are in anti-correlation.
A computer device comprising a memory and a processor, the memory storing a computer program that, when executed by the processor, causes the processor to perform the steps of:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
A computer-readable storage medium storing a computer program which, when executed by a processor, causes the processor to perform the steps of:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
The embodiment of the invention has the following beneficial effects:
the invention provides a display method, a display device and computer equipment of a digital pathological section, which comprises the steps of firstly, obtaining a regional pathological image set corresponding to each subregion of the pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; then selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and finally, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. Therefore, in the above manner, since the final digital pathological section is displayed in an animation manner, compared with the conventional manner of displaying only a single digital pathological section, the pathological section displayed in such a manner can display more information of the pathological section due to the fact that contents of a plurality of digital pathological sections are displayed simultaneously, and risks of missed diagnosis and misdiagnosis of a disease are reduced to a certain extent.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Wherein:
FIG. 1 is a schematic flow chart illustrating an implementation of a method for displaying a digital pathological section according to an embodiment;
FIG. 2 is a flow diagram illustrating an implementation of step 104 in one embodiment;
FIG. 3 is a diagram illustrating generation of an animated image of a pathological section from a panoramic image of pathological sections of different sharpness in one embodiment;
FIG. 4 is a flow diagram illustrating an implementation of step 106 in one embodiment;
FIG. 5 is a block diagram showing a display device of a digital pathological section according to an embodiment;
FIG. 6 is a block diagram of a computer device in one embodiment.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, in an embodiment, a method for displaying a digital pathological section is provided, where an execution subject of the method for displaying a digital pathological section according to the embodiment of the present invention is a device capable of implementing the method for displaying a digital pathological section according to the embodiment of the present invention, the device is provided with a display screen, the device may include, but is not limited to, a server and a terminal device, and the server includes, but is not limited to, a high-performance computer and a high-performance computer cluster; the terminal devices include, but are not limited to, mobile terminal devices including, but not limited to, mobile phones, tablet computers, smart watches, and laptops, and desktop terminal devices including, but not limited to, desktop computers and in-vehicle computers. The display method of the digital pathological section specifically comprises the following steps:
step S102, a regional pathological image set corresponding to each subregion of the pathological section is obtained, and the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels.
Pathological sections, which refer to surgically removed tissue, are often examined microscopically for disease by a physician viewing a magnified image of the cells of the pathological section. The digital pathological section corresponding to the pathological section is a section in which the pathological section is displayed as a digital image.
In order to obtain a panoramic image of a pathological section, the pathological section is divided into a plurality of sub-regions, then a scanned image of each sub-region of the pathological section is obtained, and finally the scanned images of each sub-region of the pathological section are spliced to obtain the panoramic image of the pathological section.
In the embodiment of the invention, one pathological section is divided into a plurality of sub-areas, each sub-area corresponds to one regional pathological image set, and regional focusing images of different focusing levels corresponding to the sub-areas are stored in the regional pathological image set.
The focusing layer is a layer of the pathological section aligned with the microscope camera, and in the actual scanning and shooting process, the focal length of the microscope camera is changed by adjusting the micro adjusting screw, so that the microscope camera scans the layer of the pathological section sub-region.
In the embodiment of the invention, a microscope camera is aligned to a plurality of different focusing layers of the sub-area to scan, so that the focusing images of the corresponding number of areas are obtained, and the focusing images of the areas are stored in the pathological image set of the areas corresponding to the sub-area.
And S104, selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section.
The pathological section panoramic image refers to an image capable of reflecting all the subareas of the pathological section.
If the pathological section is divided into N subregions, selecting a region focusing image from the region pathological image set corresponding to each subregion so as to obtain N region focusing images, and splicing the N region focusing images to obtain the pathological section panoramic image.
In the embodiment of the invention, the area focusing image has multiple selection modes, so that a pathological section panoramic image is generated.
The first method is as follows: random selection
Specifically, one area focusing image is randomly selected from the area pathological image set each time and spliced to obtain one pathological section panoramic image, and then a pathological section animation image is generated and displayed according to a plurality of pathological section panoramic images generated through random selection.
The second method comprises the following steps: selection based on sharpness
Specifically, as shown in fig. 2, the selecting a region focusing image from each of the region pathology image sets in step 104 for stitching includes: 104A, acquiring the definition of each region focusing image in each region pathological image set; and 104B, selecting a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
As an embodiment of the present invention, after the acquiring the sharpness of the in-focus image of each region in each region pathology image set, the method further includes: sequencing the definition of each region focusing image in each region pathological image set to obtain a sequencing result of the definition of each region focusing image; the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps: and selecting a region focusing image with different definition from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
Here, first, for each regional pathological image set, the regional focus images in the regional pathological image set are sorted according to the definition, and it is assumed that the sorting result of the regional pathological image set 1 is: the definition of the area focusing image 11 is A, the definition of the area focusing image 12 is B, and the definition of the area focusing image 13 is C; the result of the ordering of the regional pathology image set 2 is: the definition of the area focusing image 21 is B, the definition of the area focusing image 22 is C, and the definition of the area focusing image 23 is A; the result of the ordering of the regional pathology image set 3 is: the resolution of the area-focused image 31 is C, the resolution of the area-focused image 32 is a, and the resolution of the area-focused image 33 is B.
Assuming that three pathological section panoramic images need to be spliced, the first pathological section panoramic image adopts an area focusing image 11, an area focusing image 21 and an area focusing image 31, and the splicing result is ABC; the second pathological section panoramic image adopts the area focusing image 12, the area focusing image 22 and the area focusing image 32, and the splicing result is a BCA; the second pathological section panoramic image adopts the area focusing image 13, the area focusing image 23 and the area focusing image 33, and the splicing result is CAB.
As an embodiment of the present invention, after the acquiring the sharpness of the in-focus image of each region in each region pathology image set, the method further includes: sequencing the definition of each region focusing image in each region pathological image set to obtain a sequencing result of the definition of each region focusing image; the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps: and selecting a region focusing image with the highest definition from the unselected images in each region pathological image set for splicing according to the sequencing result of the definition of each region focusing image in the region pathological image set.
As another example, assuming that three pathological section panoramic images need to be stitched, the first pathological section panoramic image adopts the area-focused image with the highest resolution: the region focusing image 11, the region focusing image 23 and the region focusing image 32, and the splicing result is AAA; the second pathological section panoramic image adopts an area focusing image with second high definition: the region focusing image 12, the region focusing image 21 and the region focusing image 33 are spliced to obtain a result BBB; the third pathological section panoramic image adopts an area focusing image with the lowest definition: the region-focused image 13, the region-focused image 22, and the region-focused image 31 are merged, and the result of the merging is CCC.
Assuming that different degrees of sharpness are represented by a to C, then, as shown in fig. 3, different animated images of pathological sections can be obtained.
The third method comprises the following steps: selection according to focusing layer
Specifically, the step 104 of selecting a region focusing image from each of the region pathology image sets for stitching includes: and selecting a region focusing image with different focusing layers from each region pathological image set for splicing.
For example, the three pathological section panoramic images are spliced by using the area focusing images of the focusing layers 1, 2 and 3, and the splicing results of the three pathological section panoramic images are 123, 231 and 312.
Specifically, the step 104 of selecting a region focusing image from each of the region pathology image sets for stitching includes: respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing; the generating and displaying of the pathological section cartoon image according to the plurality of pathological section panoramic images comprises: and generating and displaying a pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
Here, each regional pathology image set stores a plurality of regional focus images of the same focus level. For example, the regional focusing images of the focusing layers 1, 2 and 3 are stored in the regional pathological image sets 1, 2 and 3, and the regional focusing images of the focusing layers 1 in the regional pathological image sets 1, 2 and 3 are adopted for the first pathological section panoramic image for splicing, wherein the splicing result is 111; splicing the second pathological section panoramic image by adopting the area focusing images with the focusing layer surface of 2 in the area pathological image sets 1, 2 and 3, wherein the splicing result is 222; and for the third pathological section panoramic image, splicing the focusing images of the focusing layer face of 3 in the regional pathological image sets 1, 2 and 3, wherein the splicing result is 333.
The generating of the pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images comprises the following steps: and generating a pathological section cartoon image from the plurality of pathological section panoramic images according to the focusing layer sequence.
For example, the pathological section panoramic image obtained by stitching the area focus images with the focus level 1 is displayed at time t1 to t2, the pathological section panoramic image obtained by stitching the area focus images with the focus level 2 is displayed at time t2 to t3, and the pathological section panoramic image obtained by stitching the area focus images with the focus level 3 is displayed at time t3 to t 4.
Alternatively, the pathology section panoramic image obtained by stitching the area focus images with the focus plane of 1 is displayed at time t1 to t2, the pathology section panoramic image obtained by stitching the area focus images with the focus plane of 3 is displayed at time t2 to t3, and the pathology section panoramic image obtained by stitching the area focus images with the focus plane of 2 is displayed at time t3 to t 4.
And S106, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
In the embodiment of the present invention, assuming that there are N area-in-focus images in each regional pathology image set, N pieces of pathology slice panoramic images may be generated, and N 'pieces of pathology slice panoramic images (N' < N) may also be generated.
Through a plurality of splicing operations, a plurality of pathological section panoramic images can be obtained. And displaying the plurality of pathological section panoramic images in a certain display time length respectively so as to generate pathological section animation images, and then displaying the generated pathological section animation images on a display screen so as to facilitate doctors to diagnose diseases.
As an embodiment of the present invention, as shown in fig. 4, the step 106 of generating a pathological section animation image from the plurality of pathological section panoramic images includes: step 106A, scoring the image quality of the multiple pathological section panoramic images to obtain a scoring result of each pathological section panoramic image; step 106B, determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image; and 106C, generating a pathological section animation image according to the display duration of each pathological section panoramic image.
Image quality, may include, but is not limited to, image sharpness. For example, assuming that the image quality includes only the image sharpness, the pathology slice panoramic image includes 9 area-in-focus images, and the score result of each area-in-focus image is 60 points, 80 points, 90 points, 60 points, and 60 points, so that the score result of the pathology slice panoramic image is: (60+60+80+80+90+90+60+60 +60)/9 ═ 71.1.
The pathological section panoramic images with different image qualities can have the same display duration or different display durations, and the display duration of the pathological section panoramic images can be flexibly set, so that doctors can diagnose diseases more favorably. For example, when the scoring result of the pathology slice panoramic image is better, the display time of the pathology slice panoramic image is longer, so that a doctor can conveniently diagnose diseases according to the pathology slice panoramic image with high quality.
As an embodiment of the present invention, the determining, in step 106B, a display duration of the corresponding pathology slice panoramic image according to the scoring result of each pathology slice panoramic image includes: and acquiring a corresponding relation table of the score and the display duration, and determining the display duration of the corresponding pathological section panoramic image according to the score result of each pathological section panoramic image and the corresponding relation table, wherein the score and the display duration in the corresponding relation table are in inverse correlation.
The corresponding relation table of the score and the display duration records the corresponding relation of the score and the display duration as shown in table 1, and the display duration corresponding to the score can be acquired according to the score recorded in the table. It should be noted that the score recorded in the correspondence table is inversely related to the display duration, and the higher the score is, the shorter the display duration is. Since the higher the score value is, the more quickly the doctor can see the content displayed by the pathological section panoramic image, the shorter the pathological section panoramic image can be displayed, and the lower the score value is, the more time the doctor needs to see the content displayed by the pathological section panoramic image, so the pathological section panoramic image needs to be displayed for a long time.
TABLE 1
Firstly, acquiring a regional pathological image set corresponding to each subregion of the pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; then selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and finally, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. Therefore, in the above manner, since the final digital pathological section is displayed in an animation manner, compared with the conventional manner of displaying only a single digital pathological section, the pathological section displayed in such a manner can display more information of the pathological section due to the fact that contents of a plurality of digital pathological sections are displayed simultaneously, and risks of missed diagnosis and misdiagnosis of a disease are reduced to a certain extent.
As shown in fig. 5, there is provided a display device 500 for digital pathological section, which specifically includes:
an obtaining module 502, configured to obtain a regional pathological image set corresponding to each sub-region of a pathological section, where the regional pathological image set includes regional focusing images of the corresponding sub-regions on different focusing levels;
a stitching module 504, configured to select a region focusing image from each of the region pathological image sets to be stitched, so as to obtain a pathological section panoramic image of the pathological section;
and the generating module 506 is configured to acquire a plurality of pathological section panoramic images obtained through multiple splicing, and generate and display a pathological section animation image according to the plurality of pathological section panoramic images.
Firstly, acquiring a regional pathological image set corresponding to each subregion of the pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; then selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and finally, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. Therefore, in the above manner, since the final digital pathological section is displayed in an animation manner, compared with the conventional manner of displaying only a single digital pathological section, the pathological section displayed in such a manner can display more information of the pathological section due to the fact that contents of a plurality of digital pathological sections are displayed simultaneously, and risks of missed diagnosis and misdiagnosis of a disease are reduced to a certain extent.
In one embodiment, the splicing module 504 includes:
the definition acquisition module is used for acquiring the definition of each region focusing image in each region pathological image set;
and the definition splicing module is used for selecting one region focusing image from each region pathological image set to splice according to the definition of each region focusing image in the region pathological image sets.
In one embodiment, the apparatus 50 further includes:
the definition sorting module is used for sorting the definition of each region focusing image in each region pathological image set to obtain a sorting result of the definition of each region focusing image;
the definition stitching module comprises: and the highest-definition splicing module is used for selecting a region focusing image with highest definition from the unselected images in each region pathological image set according to the sequencing result of the definition of each region focusing image in the region pathological image set and splicing the selected region focusing images.
In one embodiment, the splicing module 504 includes:
the same focusing layer splicing module is used for respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generating module 506 includes: and the same focusing layer generation module is used for generating and displaying the pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
In one embodiment, the generating module 506 includes:
the scoring module is used for scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image;
the duration determining module is used for determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image;
and the duration generation module is used for generating a pathological section animation image according to the display duration of each pathological section panoramic image.
In one embodiment, the duration determining module includes:
and the time length anti-correlation module is used for acquiring a corresponding relation table of the score and the display time length, determining the display time length of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image and the corresponding relation table, and the score and the display time length in the corresponding relation table are in anti-correlation.
FIG. 6 is a diagram illustrating an internal structure of a computer device in one embodiment. The computer device is provided with a display screen, and the computer device can comprise but is not limited to a server and a terminal device, wherein the server comprises but is not limited to a high-performance computer and a high-performance computer cluster; the terminal devices include, but are not limited to, mobile terminal devices including, but not limited to, mobile phones, tablet computers, smart watches, and laptops, and desktop terminal devices including, but not limited to, desktop computers and in-vehicle computers. As shown in fig. 6, the computer device includes a processor, a memory, a network interface, and a display screen connected by a system bus. Wherein the memory includes a non-volatile storage medium and an internal memory. The non-volatile storage medium of the computer device stores an operating system and may also store a computer program which, when executed by the processor, causes the processor to implement a method of displaying a digital pathology slice. The internal memory may also have a computer program stored therein, which when executed by the processor, causes the processor to perform a method of displaying a digital pathology slice. Those skilled in the art will appreciate that the architecture shown in fig. 6 is merely a block diagram of some of the structures associated with the disclosed aspects and is not intended to limit the computing devices to which the disclosed aspects apply, as particular computing devices may include more or less components than those shown, or may combine certain components, or have a different arrangement of components.
In one embodiment, the method for displaying digital pathological section provided by the present application can be implemented in the form of a computer program, and the computer program can be run on a computer device as shown in fig. 6. The memory of the computer device may store therein the various program templates constituting the display means of the digital pathological section. Such as an acquisition module 502, a stitching module 504, and a generation module 506.
A computer device comprising a memory and a processor, the memory storing a computer program that, when executed by the processor, causes the processor to perform the steps of:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
The computer equipment firstly acquires a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; then selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and finally, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. Therefore, in the above manner, since the final digital pathological section is displayed in an animation manner, compared with the conventional manner of displaying only a single digital pathological section, the pathological section displayed in such a manner can display more information of the pathological section due to the fact that contents of a plurality of digital pathological sections are displayed simultaneously, and risks of missed diagnosis and misdiagnosis of a disease are reduced to a certain extent.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
acquiring the definition of each region focusing image in each region pathological image set;
and selecting a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
In one embodiment, the computer program, when executed by the processor, is further configured to:
after the definition of each region focusing image in each region pathological image set is obtained, sorting the definition of each region focusing image in each region pathological image set to obtain a sorting result of the definition of each region focusing image;
the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps:
and selecting a region focusing image with the highest definition from the unselected images in each region pathological image set for splicing according to the sequencing result of the definition of each region focusing image in the region pathological image set.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generating and displaying of the pathological section cartoon image according to the plurality of pathological section panoramic images comprises:
and generating and displaying a pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
In one embodiment, the generating a pathological section animation image from the plurality of pathological section panoramic images includes:
scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image;
determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image;
and generating a pathological section cartoon image according to the display duration of each pathological section panoramic image.
In one embodiment, the determining, according to the scoring result of each of the pathological section panoramic images, the display duration of the corresponding pathological section panoramic image includes:
and acquiring a corresponding relation table of the score and the display duration, and determining the display duration of the corresponding pathological section panoramic image according to the score result of each pathological section panoramic image and the corresponding relation table, wherein the score and the display duration in the corresponding relation table are in inverse correlation.
In one embodiment, a computer-readable storage medium is proposed, in which a computer program is stored which, when executed by a processor, causes the processor to carry out the steps of:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
and acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images.
Firstly, acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels; then selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section; and finally, acquiring a plurality of pathological section panoramic images obtained by multiple splicing, and generating and displaying a pathological section animation image according to the plurality of pathological section panoramic images. Therefore, in the above manner, since the final digital pathological section is displayed in an animation manner, compared with the conventional manner of displaying only a single digital pathological section, the pathological section displayed in such a manner can display more information of the pathological section due to the fact that contents of a plurality of digital pathological sections are displayed simultaneously, and risks of missed diagnosis and misdiagnosis of a disease are reduced to a certain extent.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
acquiring the definition of each region focusing image in each region pathological image set;
and selecting a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
In one embodiment, the computer program, when executed by the processor, is further configured to:
after the definition of each region focusing image in each region pathological image set is obtained, sorting the definition of each region focusing image in each region pathological image set to obtain a sorting result of the definition of each region focusing image;
the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps:
and selecting a region focusing image with the highest definition from the unselected images in each region pathological image set for splicing according to the sequencing result of the definition of each region focusing image in the region pathological image set.
In one embodiment, the selecting a region-focused image from each of the region pathology image sets for stitching includes:
respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generating and displaying of the pathological section cartoon image according to the plurality of pathological section panoramic images comprises:
and generating and displaying a pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
In one embodiment, the generating a pathological section animation image from the plurality of pathological section panoramic images includes:
scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image;
determining the display duration of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image;
and generating a pathological section cartoon image according to the display duration of each pathological section panoramic image.
In one embodiment, the determining, according to the scoring result of each of the pathological section panoramic images, the display duration of the corresponding pathological section panoramic image includes:
and acquiring a corresponding relation table of the score and the display duration, and determining the display duration of the corresponding pathological section panoramic image according to the score result of each pathological section panoramic image and the corresponding relation table, wherein the score and the display duration in the corresponding relation table are in inverse correlation.
It should be noted that the above-mentioned method for displaying digital pathological section, device for displaying digital pathological section, computer device and computer readable storage medium belong to a general inventive concept, and the contents in the embodiments of the method for displaying digital pathological section, device for displaying digital pathological section, computer device and computer readable storage medium are mutually applicable.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by a computer program, which can be stored in a non-volatile computer-readable storage medium, and can include the processes of the embodiments of the methods described above when the program is executed. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present application. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A method for displaying a digital pathological section, comprising:
acquiring a regional pathological image set corresponding to each subregion of a pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
selecting a region focusing image from each region pathological image set for splicing to obtain a pathological section panoramic image of the pathological section;
acquiring a plurality of pathological section panoramic images obtained by multiple splicing;
scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image, wherein the scoring result comprises the following steps: for each pathological section panoramic image, acquiring a score result of a focusing image of each area in the pathological section panoramic image, calculating a mean value of the score results of the focusing images of each area, and taking the mean value as the score result of the pathological section panoramic image;
acquiring a corresponding relation table of scores and display durations, and determining the display durations of the corresponding pathological section panoramic images according to the scoring results of the pathological section panoramic images and the corresponding relation table, wherein the scores and the display durations in the corresponding relation table are in inverse correlation;
and generating a pathological section cartoon image according to the display duration of each pathological section panoramic image.
2. The method of claim 1, wherein said selecting a region-in-focus image from each of said set of regional pathology images for stitching comprises:
acquiring the definition of each region focusing image in each region pathological image set;
and selecting a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set for splicing.
3. The method of claim 2, wherein after said obtaining the sharpness of the in-focus image of each of said regions in each of said sets of regional pathology images, further comprising:
sequencing the definition of each region focusing image in each region pathological image set to obtain a sequencing result of the definition of each region focusing image;
the selecting and splicing a region focusing image from each region pathological image set according to the definition of each region focusing image in the region pathological image set comprises the following steps:
and selecting a region focusing image with the highest definition from the unselected images in each region pathological image set for splicing according to the sequencing result of the definition of each region focusing image in the region pathological image set.
4. The method of claim 1, wherein said selecting a region-in-focus image from each of said set of regional pathology images for stitching comprises:
respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generating and displaying of the pathological section cartoon image according to the plurality of pathological section panoramic images comprises:
and generating and displaying a pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
5. A display device for digital pathological sections, comprising:
the acquisition module is used for acquiring a regional pathological image set corresponding to each subregion of the pathological section, wherein the regional pathological image set comprises regional focusing images of the corresponding subregion on different focusing levels;
the splicing module is used for selecting a region focusing image from each region pathological image set to splice to obtain a pathological section panoramic image of the pathological section;
the generation module is used for acquiring a plurality of pathological section panoramic images obtained by splicing for a plurality of times;
the generation module comprises:
the scoring module is used for scoring the image quality of the plurality of pathological section panoramic images to obtain a scoring result of each pathological section panoramic image, and comprises: for each pathological section panoramic image, acquiring a score result of a focusing image of each area in the pathological section panoramic image, calculating a mean value of the score results of the focusing images of each area, and taking the mean value as the score result of the pathological section panoramic image;
the time length anti-correlation module is used for acquiring a corresponding relation table of the score and the display time length, determining the display time length of the corresponding pathological section panoramic image according to the scoring result of each pathological section panoramic image and the corresponding relation table, and the score and the display time length in the corresponding relation table are in anti-correlation;
and the duration generation module is used for generating a pathological section animation image according to the display duration of each pathological section panoramic image.
6. The apparatus of claim 5, wherein the splicing module comprises:
the definition acquisition module is used for acquiring the definition of each region focusing image in each region pathological image set;
and the definition splicing module is used for selecting one region focusing image from each region pathological image set to splice according to the definition of each region focusing image in the region pathological image sets.
7. The apparatus of claim 6, wherein the apparatus further comprises:
the definition sorting module is used for sorting the definition of each region focusing image in each region pathological image set to obtain a sorting result of the definition of each region focusing image;
the definition stitching module comprises: and the highest-definition splicing module is used for selecting a region focusing image with highest definition from the unselected images in each region pathological image set according to the sequencing result of the definition of each region focusing image in the region pathological image set and splicing the selected region focusing images.
8. The apparatus of claim 5, wherein the splicing module comprises:
the same focusing layer splicing module is used for respectively selecting a region focusing image with the same focusing layer from each region pathological image set for splicing;
the generation module comprises: and the same focusing layer generation module is used for generating and displaying the pathological section cartoon image according to the focusing layers corresponding to the plurality of pathological section panoramic images.
9. A computer device comprising a memory, a processor and a computer program stored in the memory and executable on the processor, wherein the processor when executing the computer program implements the steps of the method of displaying a digital pathology slice according to any one of claims 1 to 4.
10. A computer-readable storage medium, in which a computer program is stored, which, when being executed by a processor, carries out the steps of the method for displaying a digital pathological section according to any one of claims 1 to 4.
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