CN109994189A - Display methods, device and the computer equipment of digital pathological section - Google Patents

Display methods, device and the computer equipment of digital pathological section Download PDF

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CN109994189A
CN109994189A CN201910189850.3A CN201910189850A CN109994189A CN 109994189 A CN109994189 A CN 109994189A CN 201910189850 A CN201910189850 A CN 201910189850A CN 109994189 A CN109994189 A CN 109994189A
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region
pathological
image
pathological section
clarity
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CN109994189B (en
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车拴龙
罗丕福
刘栋
刘斯
李映华
梁小曼
苏钜铭
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Guangzhou Kingmed Diagnostics Central Co Ltd
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Guangzhou Kingmed Diagnostics Central Co Ltd
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    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00Geometric image transformations in the plane of the image
    • G06T3/40Scaling of whole images or parts thereof, e.g. expanding or contracting
    • G06T3/4038Image mosaicing, e.g. composing plane images from plane sub-images
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/40ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T13/00Animation

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  • Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
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Abstract

The embodiment of the invention discloses a kind of display methods of digital pathological section, device and computer equipments, include: to obtain the corresponding region pathological image set of pathological section each subregion, includes region focus image of the respective sub-areas in different focus level in the region pathological image set;It selects a region focus image to be spliced from each region pathological image set, obtains the pathological section panoramic picture of the pathological section;Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, generate pathological section animated image according to multiple described pathological section panoramic pictures and show.Aforesaid way can fail to pinpoint a disease in diagnosis and mistaken diagnosis risk reducing disease to a certain degree.

Description

Display methods, device and the computer equipment of digital pathological section
Technical field
The present invention relates to pathological diagnosis technical field more particularly to a kind of display methods of digital pathological section, device and Computer equipment.
Background technique
Pathological diagnosis refers to doctor under the microscope by the magnocell of observation operation Operated Specimens come diagnosed disease.Number Word pathology, refer to doctor according to high-resolution digital pathological section come diagnosed disease, specifically, doctor passes through terminal device The two dimensional image that display end is presented is observed to diagnose the illness.
Current digital pathological section scanner adopts drawing system by optical amplification system and high picture element scan and obtains number Then pathological section diagnoses the illness at display end.Such medical diagnosis on disease mode can bring very big convenience to doctor, doctor It is raw no longer necessary against microscope diagnosed disease.
But be only the single picture to focus layer by the digital pathological section that digital pathological section scanner obtains, it sees It examines such picture and directly there is very big difference by micro- sem observation pathological section, and is single to focus layer by observing Picture carry out diagnosed disease compared to directly by micro- sem observation diagnosed disease since the information of loss is too many, increase and fail to pinpoint a disease in diagnosis With the risk of mistaken diagnosis.
Summary of the invention
Based on this, it is necessary in view of the above-mentioned problems, proposing that a kind of reduction is failed to pinpoint a disease in diagnosis and the digital pathological section of mistaken diagnosis risk Display methods, device and computer equipment.
A kind of display methods of digital pathological section, which comprises
The corresponding region pathological image set of pathological section each subregion is obtained, is wrapped in the region pathological image set Respective sub-areas is included in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathology The pathological section panoramic picture of slice;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
Obtain the clarity of each region focus image in each region pathological image set;
According to the clarity of each region focus image in the region pathological image set from each region pathology A region focus image is selected to be spliced in image collection.
Each region pair in each region pathological image set is obtained described in one of the embodiments, After the clarity of burnt image, further includes:
The clarity of each region focus image in each region pathological image set is ranked up, is obtained To the ranking results of the clarity of each region focus image;
The clarity according to each region focus image in the region pathological image set is from each region A region focus image is selected to be spliced in pathological image set, comprising:
According to the ranking results of the clarity of the region focus image each in the region pathological image set, from every The highest region focus image of a clarity is selected in the image of unselected mistake in a region pathological image set Spliced.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
The region focus image of an identical focusing level is respectively selected to carry out from each region pathological image set Splicing;
Described multiple pathological section panoramic pictures according to generate pathological section animated image and show, comprising:
Pathological section animated image is generated according to the corresponding focusing level of multiple described pathological section panoramic pictures and is shown.
Described multiple pathological section panoramic pictures according to generate pathological section animation figure in one of the embodiments, Picture, comprising:
It scores the picture quality of multiple pathological section panoramic pictures, obtains every pathological section panorama The appraisal result of image;
According to the appraisal result of pathological section panoramic picture described in every, the aobvious of corresponding pathological section panoramic picture is determined Show duration;
Pathological section animated image is generated according to the display duration of each pathological section panoramic picture.
The appraisal result according to pathological section panoramic picture described in every in one of the embodiments, determining pair The display duration for the pathological section panoramic picture answered, comprising:
It obtains score value and shows the mapping table of duration, according to the appraisal result of pathological section panoramic picture described in every The display duration of corresponding pathological section panoramic picture is determined with the mapping table, score value and aobvious in the mapping table Grow up to inverse correlation when showing.
A kind of display device of digital pathological section, comprising:
Module is obtained, for obtaining the corresponding region pathological image set of pathological section each subregion, the region disease Managing in image collection includes region focus image of the respective sub-areas in different focus level;
Splicing module, for selecting a region focus image to be spelled from each region pathological image set It connects, obtains the pathological section panoramic picture of the pathological section;
Generation module, for obtaining multiple the described pathological section panoramic pictures for repeatedly splicing and obtaining, according to it is described multiple Pathological section panoramic picture generates pathological section animated image and shows.
The splicing module in one of the embodiments, comprising:
Clarity obtains module, for obtaining each region focus image in each region pathological image set Clarity;
Clarity splicing module, for the clarity according to each region focus image in the region pathological image set A region focus image is selected to be spliced from each region pathological image set.
Described device in one of the embodiments, further includes:
Clarity sorting module, for each region focus image in each region pathological image set Clarity be ranked up, obtain the ranking results of the clarity of each region focus image;
The clarity splicing module, comprising: highest clarity splicing module, for according to the region pathological image collection The ranking results of the clarity of each region focus image in conjunction, from each region pathological image set not by The highest region focus image of a clarity is selected to be spliced in the image chosen.
The splicing module in one of the embodiments, comprising:
It is identical to focus layer splicing module, for respectively selecting an identical focusing from each region pathological image set The region focus image of level is spliced;
The generation module, comprising: it is identical to focus layer generation module, for according to multiple described pathological section panoramic pictures Corresponding focusing level generates pathological section animated image and shows.
The generation module in one of the embodiments, comprising:
Grading module scores for the picture quality to multiple pathological section panoramic pictures, obtains every institute State the appraisal result of pathological section panoramic picture;
Duration determining module determines corresponding disease for the appraisal result according to pathological section panoramic picture described in every The display duration of reason slice panoramic picture;
Duration generation module, it is dynamic for generating pathological section according to the display duration of each pathological section panoramic picture Picture picture.
The duration determining module in one of the embodiments, comprising:
Duration inverse correlation module is cut for obtaining score value and showing the mapping table of duration according to pathology described in every The appraisal result of piece panoramic picture and the mapping table determine the display duration of corresponding pathological section panoramic picture, described Score value grows up to inverse correlation with when showing in mapping table.
A kind of computer equipment, including memory and processor, the memory are stored with computer program, the calculating When machine program is executed by the processor, so that the processor executes following steps:
The corresponding region pathological image set of pathological section each subregion is obtained, is wrapped in the region pathological image set Respective sub-areas is included in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathology The pathological section panoramic picture of slice;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.
A kind of computer readable storage medium is stored with computer program, when the computer program is executed by processor, So that the processor executes following steps:
The corresponding region pathological image set of pathological section each subregion is obtained, is wrapped in the region pathological image set Respective sub-areas is included in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathology The pathological section panoramic picture of slice;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.
Implement the embodiment of the present invention, will have the following beneficial effects:
The invention proposes a kind of display methods of digital pathological section, device and computer equipments, first acquisition pathology It is sliced the corresponding region pathological image set of each subregion, includes respective sub-areas in the region pathological image set not With the region focus image of focusing level;Then a region focus image is selected from each region pathological image set Spliced, obtains the pathological section panoramic picture of the pathological section;It finally obtains and repeatedly splices multiple obtained described diseases Reason slice panoramic picture, generates pathological section animated image according to multiple described pathological section panoramic pictures and shows.On as it can be seen that Mode is stated, since final digital pathological section is the display carried out in animated way, shows individual compared to existing The mode of digital pathological section, the pathological section that such mode is shown due to and meanwhile show in multiple digital pathological sections Hold, so more pathological section information can be shown, reduces disease to a certain extent and fail to pinpoint a disease in diagnosis risk with mistaken diagnosis, and And the pathological section that shows of such mode is compared to the mode for only showing individual digital pathological section, closer to directly passing through The mode of micro- sem observation pathological section also reduces disease to a certain extent and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with It obtains other drawings based on these drawings.
Wherein:
Fig. 1 is the implementation process schematic diagram of the display methods of digital pathological section in one embodiment;
Fig. 2 is the implementation process schematic diagram of step 104 in one embodiment;
Fig. 3 is to generate pathological section animated image according to the pathological section panoramic picture of different clarity in one embodiment Schematic diagram;
Fig. 4 is the implementation process schematic diagram of step 106 in one embodiment;
Fig. 5 is the structural block diagram of the display device of digital pathological section in one embodiment;
Fig. 6 is the structural block diagram of computer equipment in one embodiment.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
As shown in Figure 1, in one embodiment, providing a kind of display methods of digital pathological section, the present invention is implemented The executing subject of the display methods of digital pathological section described in example is that can be realized digital pathology described in the embodiment of the present invention The equipment of the display methods of slice, the equipment are provided with display screen, which can include but is not limited to server and terminal is set Standby, the server includes but is not limited to high-performance computer and high-performance computer cluster;The terminal device includes but not It is limited to mobile terminal device and terminal console equipment, the mobile terminal device includes but is not limited to mobile phone, tablet computer, intelligence Wrist-watch and laptop, the terminal console equipment includes but is not limited to desktop computer and vehicle-mounted computer.The number pathology is cut The display methods of piece, specifically comprises the following steps:
Step S102 obtains the corresponding region pathological image set of pathological section each subregion, the region pathology figure Image set includes region focus image of the respective sub-areas in different focus level in closing.
Pathological section refers to the cell tissue of operation excision, and doctor is often through observation pathological section under the microscope Magnocell image carrys out diagnosed disease.Digital pathological section corresponding with pathological section, refers to pathological section with digital picture Mode shown.
The panoramic picture of pathological section in order to obtain needs that pathological section is divided into multiple subregions first, then To the scan image of each sub-regions of pathological section, finally the scan image of each sub-regions of pathological section is spliced, is obtained To the panoramic picture of pathological section.
In embodiments of the present invention, a pathological section is divided into multiple subregions, then each subregion corresponding one A region pathological image set stores the region pair of the corresponding different focus level of subregion in the region pathological image set Burnt image.
Focusing level refers to a certain layer of the pathological section of microscope camera alignment, in actual scanning shooting process, Change the focal length of microscope camera by adjusting minor adjustments spiral, so that microscope camera be made to be directed at pathological section sub-district The a certain layer in domain is scanned.
In embodiments of the present invention, multiple and different focusing levels of microscope camera alignment subregion are swept It retouches, obtains the region focus image of corresponding number, focus image is stored in region corresponding with subregion pathology by these regions In image collection.
Step S104 selects a region focus image to be spliced, obtains from each region pathological image set To the pathological section panoramic picture of the pathological section.
Pathological section panoramic picture refers to the image of reflection pathological section whole subregion.
Assuming that pathological section has been partitioned into N number of subregion, then from the corresponding region pathological image collection of each subregion A region focus image is selected in conjunction, and so as to obtain N region focus images, N region focus images are spelled It connects, obtains pathological section panoramic picture.
In embodiments of the present invention, there are many selection modes for region focus image, to generate pathological section panoramic picture.
Mode one: random selection
Spliced specifically, randomly choosing a region focus image from the pathological image set of region every time, is obtained One pathological section panoramic picture, the pathological section panoramic picture then generated according to multiple by random selection generate pathology and cut Piece animated image is simultaneously shown.
Mode two: it is selected according to clarity
Specifically, as shown in Fig. 2, a region is selected described in step 104 from each region pathological image set Focus image is spliced, comprising: step 104A obtains each region focusing in each region pathological image set The clarity of image;Step 104B, according to the clarity of each region focus image in the region pathological image set from every A region focus image is selected to be spliced in a region pathological image set.
It is each described in each region pathological image set of acquisition as one embodiment of the present invention After the clarity of region focus image, further includes: to each region pair in each region pathological image set The clarity of burnt image is ranked up, and obtains the ranking results of the clarity of each region focus image;It is described according to institute The clarity for stating each region focus image in the pathological image set of region is selected from each region pathological image set One region focus image is spliced, comprising: according in the region pathological image set each region focus image it is clear Clear degree selects the region focus image of a different clarity to be spliced from each region pathological image set.
Herein, first to each region pathological image set, according to clarity in the region pathological image set Region focus image is ranked up, it is assumed that the ranking results of region pathological image set 1 are as follows: the clarity of region focus image 11 For A, the clarity of region focus image 12 is B, and the clarity of region focus image 13 is C;The row of region pathological image set 2 Sequence result are as follows: the clarity of region focus image 21 is B, and the clarity of region focus image 22 is C, region focus image 23 Clarity is A;The ranking results of region pathological image set 3 are as follows: the clarity of region focus image 31 is C, region focusing figure The clarity of picture 32 is A, and the clarity of region focus image 33 is B.
Assuming that needing to splice three pathological section panoramic pictures, then first pathological section panoramic picture is focused using region Image 11, region focus image 21 and region focus image 31, splicing result ABC;Second pathological section panoramic picture is adopted With region focus image 12, region focus image 22 and region focus image 32, splicing result BCA;Second pathological section Panoramic picture uses region focus image 13, region focus image 23 and region focus image 33, splicing result CAB.
It is each described in each region pathological image set of acquisition as one embodiment of the present invention After the clarity of region focus image, further includes: to each region pair in each region pathological image set The clarity of burnt image is ranked up, and obtains the ranking results of the clarity of each region focus image;It is described according to institute The clarity for stating each region focus image in the pathological image set of region is selected from each region pathological image set One region focus image is spliced, comprising: according to the region focus image each in the region pathological image set Clarity ranking results, select a Zhang Qing from the image of the unselected mistake in each region pathological image set The clear highest region focus image of degree is spliced.
For another example above-mentioned example, it is assumed that need to splice three pathological section panoramic pictures, then first pathological section panorama sketch As using region focus image most high-definition: region focus image 11, region focus image 23 and region focus image 32, Splicing result is AAA;Second pathological section panoramic picture region focus image high using clarity time: region focus image 12, region focus image 21 and region focus image 33, splicing result BBB;Third pathological section panoramic picture is using clear The minimum region focus image of clear degree: region focus image 13, region focus image 22 and region focus image 31 are spliced, Splicing result is CCC.
Assuming that different clarity is indicated with A to C, then, as shown in figure 3, available different pathological section animation Image.
Mode three: it is selected according to focusing level
Specifically, described in step 104 from each region pathological image set select a region focus image into Row splicing, comprising: from each region pathological image set select a different focus level region focus image into Row splicing.
For example, the region focus image for being all made of focusing level 1,2 and 3 for three pathological section panoramic pictures is spelled It connects, the splicing result for obtaining three pathological section panoramic pictures is 123,231 and 312.
Specifically, described in step 104 from each region pathological image set select a region focus image into Row splicing, comprising: the region focus image of an identical focusing level is respectively selected from each region pathological image set Spliced;Described multiple pathological section panoramic pictures according to generate pathological section animated image and show, comprising: according to The corresponding focusing level of described multiple pathological section panoramic pictures generates pathological section animated image and shows.
Herein, the region focus image of multiple identical focusing levels is stored in each region pathological image set. For example, the region focus image of focusing level 1,2 and 3 is stored in region pathological image set 1,2 and 3, for first Pathological section panoramic picture uses focusing level in region pathological image set 1,2 and 3 to be spelled for 1 region focus image It connects, splicing result 111;Second pathological section panoramic picture is used in region pathological image set 1,2 and 3 to focus layer The region focus image that face is 2 is spliced, splicing result 222;Region is used for third pathological section panoramic picture The region focus image that focusing level is 3 in pathological image set 1,2 and 3 is spliced, splicing result 333.
The corresponding focusing level of described multiple pathological section panoramic pictures according to generates pathological section animated image, packet It includes: multiple pathological section panoramic pictures is sequentially generated pathological section animated image by focusing level.
For example, by the pathological section panoramic picture for using region focus image of the focusing level for 1 to splice in the time T1~t2 shown, will use focusing level be the pathological section panoramic picture that splices of 2 region focus image when Between t2~t3 shown, using focusing level be 3 the pathological section panoramic picture that splices of region focus image when Between t3~t4 shown.
Alternatively, by the pathological section panoramic picture for using region focus image of the focusing level for 1 to splice in the time T1~t2 shown, will use focusing level be the pathological section panoramic picture that splices of 3 region focus image when Between t2~t3 shown, using focusing level be 2 the pathological section panoramic picture that splices of region focus image when Between t3~t4 shown.
Step S106, multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathology Slice panoramic picture generates pathological section animated image and shows.
In embodiments of the present invention, it is assumed that have N number of region focus image in each region pathological image set, then can be with N pathological section panoramic pictures are generated, N ' (N ' < N) pathological section panoramic pictures also can be generated.
By multiple concatenation, multiple available pathological section panoramic pictures.By multiple pathological section panorama sketch As respectively being shown with certain display duration, so that pathological section animated image is generated, then by the pathological section of generation Animated image is shown in display screen, so as to diagnosis disease.
As one embodiment of the present invention, as shown in figure 4, complete according to multiple described pathological sections described in step 106 Scape image generates pathological section animated image, comprising: step 106A, to the picture quality of multiple pathological section panoramic pictures It scores, obtains the appraisal result of every pathological section panoramic picture;Step 106B, according to pathological section described in every The appraisal result of panoramic picture determines the display duration of corresponding pathological section panoramic picture;Step 106C, according to each described The display duration of pathological section panoramic picture generates pathological section animated image.
Picture quality can include but is not limited to image definition.For example, it is assumed that picture quality just only includes image clearly Degree, pathological section panoramic picture include 9 region focus images, the appraisal result of each region focus image is 60 points, 60 points, 80 points, 80 points, 90 points, 90 points, 60 points, 60 points and 60 points, then, the appraisal result of the pathological section panoramic picture are as follows: (60+ 60+80+80+90+90+60+60+60+60)/9=71.1.
Herein, the pathological section panoramic picture of different images quality can have identical display duration, can also have not Same display duration, is flexibly arranged by the display duration to pathological section panoramic picture, can be more favorable for doctor It diagnoses the illness.For example, when the appraisal result of pathological section panoramic picture is better, the display duration of the pathological section panoramic picture It is longer, doctor can be facilitated to be diagnosed the illness according to the high pathological section panoramic picture of quality in this way.
As one embodiment of the present invention, commenting according to pathological section panoramic picture described in every described in step 106B Divide as a result, determining the display duration of corresponding pathological section panoramic picture, comprising: obtain score value and show the corresponding relationship of duration Table determines that corresponding pathological section is complete according to the appraisal result of pathological section panoramic picture described in every and the mapping table The display duration of scape image, score value and when display, grow up to inverse correlation in the mapping table.
The mapping table of score value and display duration has recorded score value and shows the corresponding relationship of duration as shown in table 1, According to the score value recorded in the table, the corresponding display duration of the score value can be got.It should be noted that in mapping table Grow up to inverse correlation when the score value of record and display and score value is higher, display duration is shorter.Since score value is higher, doctor can The content that the pathological section panoramic picture is shown just is seen faster, it is possible to be shown the pathological section panoramic picture short A bit, score value is lower, the content that doctor just needs that more times is spent to see that the pathological section panoramic picture is shown, so needing The pathological section panoramic picture is shown long a bit.
Table 1
The display methods of above-mentioned digital pathological section, the first corresponding region pathology figure of acquisition pathological section each subregion Image set closes, and includes region focus image of the respective sub-areas in different focus level in the region pathological image set;Then It selects a region focus image to be spliced from each region pathological image set, obtains the disease of the pathological section Reason slice panoramic picture;It finally obtains and repeatedly splices multiple obtained described pathological section panoramic pictures, according to multiple described diseases Reason slice panoramic picture generates pathological section animated image and shows.As it can be seen that aforesaid way, due to final digital pathological section It is the display carried out in animated way, the mode of individual digital pathological section, such mode is shown compared to existing The pathological section of display is due to showing the content of multiple digital pathological sections simultaneously, so more pathological sections can be shown Information reduces disease to a certain extent and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis, also, the pathological section that such mode is shown is compared In the mode for only showing individual digital pathological section, closer to directly by way of micro- sem observation pathological section, also one Determine to reduce disease in degree and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis.
As shown in figure 5, providing a kind of display device 500 of digital pathological section, specifically include:
Module 502 is obtained, for obtaining the corresponding region pathological image set of pathological section each subregion, the region It include region focus image of the respective sub-areas in different focus level in pathological image set;
Splicing module 504, for selecting a region focus image to carry out from each region pathological image set Splicing, obtains the pathological section panoramic picture of the pathological section;
Generation module 506, for obtaining multiple the described pathological section panoramic pictures for repeatedly splicing and obtaining, according to described more Pathological section panoramic picture is opened to generate pathological section animated image and show.
The display device of above-mentioned digital pathological section, the first corresponding region pathology figure of acquisition pathological section each subregion Image set closes, and includes region focus image of the respective sub-areas in different focus level in the region pathological image set;Then It selects a region focus image to be spliced from each region pathological image set, obtains the disease of the pathological section Reason slice panoramic picture;It finally obtains and repeatedly splices multiple obtained described pathological section panoramic pictures, according to multiple described diseases Reason slice panoramic picture generates pathological section animated image and shows.As it can be seen that aforesaid way, due to final digital pathological section It is the display carried out in animated way, the mode of individual digital pathological section, such mode is shown compared to existing The pathological section of display is due to showing the content of multiple digital pathological sections simultaneously, so more pathological sections can be shown Information reduces disease to a certain extent and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis, also, the pathological section that such mode is shown is compared In the mode for only showing individual digital pathological section, closer to directly by way of micro- sem observation pathological section, also one Determine to reduce disease in degree and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis.
The splicing module 504 in one of the embodiments, comprising:
Clarity obtains module, for obtaining each region focus image in each region pathological image set Clarity;
Clarity splicing module, for the clarity according to each region focus image in the region pathological image set A region focus image is selected to be spliced from each region pathological image set.
Described device 50 in one of the embodiments, further includes:
Clarity sorting module, for each region focus image in each region pathological image set Clarity be ranked up, obtain the ranking results of the clarity of each region focus image;
The clarity splicing module, comprising: highest clarity splicing module, for according to the region pathological image collection The ranking results of the clarity of each region focus image in conjunction, from each region pathological image set not by The highest region focus image of a clarity is selected to be spliced in the image chosen.
The splicing module 504 in one of the embodiments, comprising:
It is identical to focus layer splicing module, for respectively selecting an identical focusing from each region pathological image set The region focus image of level is spliced;
The generation module 506, comprising: it is identical to focus layer generation module, for according to multiple described pathological section panoramas The corresponding focusing level of image generates pathological section animated image and shows.
The generation module 506 in one of the embodiments, comprising:
Grading module scores for the picture quality to multiple pathological section panoramic pictures, obtains every institute State the appraisal result of pathological section panoramic picture;
Duration determining module determines corresponding disease for the appraisal result according to pathological section panoramic picture described in every The display duration of reason slice panoramic picture;
Duration generation module, it is dynamic for generating pathological section according to the display duration of each pathological section panoramic picture Picture picture.
The duration determining module in one of the embodiments, comprising:
Duration inverse correlation module is cut for obtaining score value and showing the mapping table of duration according to pathology described in every The appraisal result of piece panoramic picture and the mapping table determine the display duration of corresponding pathological section panoramic picture, described Score value grows up to inverse correlation with when showing in mapping table.
Fig. 6 shows the internal structure chart of computer equipment in one embodiment.The computer equipment is provided with display screen, The computer equipment can include but is not limited to server and terminal device, and the server includes but is not limited to high-performance calculation Machine and high-performance computer cluster;The terminal device includes but is not limited to mobile terminal device and terminal console equipment, described Mobile terminal device includes but is not limited to mobile phone, tablet computer, smartwatch and laptop, the terminal console equipment packet It includes but is not limited to desktop computer and vehicle-mounted computer.As shown in fig. 6, the computer equipment includes the processing connected by system bus Device, memory, network interface and display screen.Wherein, memory includes non-volatile memory medium and built-in storage.The computer The non-volatile memory medium of equipment is stored with operating system, can also be stored with computer program, and the computer program is processed When device executes, processor may make to realize the display methods of digital pathological section.Computer can also be stored in the built-in storage Program when the computer program is executed by processor, may make processor to execute the display methods of digital pathological section.This field Technical staff is appreciated that structure shown in Fig. 6, only the block diagram of part-structure relevant to application scheme, not The restriction for the computer equipment being applied thereon to application scheme is constituted, specific computer equipment may include than in figure Shown more or fewer components perhaps combine certain components or with different component layouts.
In one embodiment, the display methods of digital pathological section provided by the present application can be implemented as a kind of computer The form of program, computer program can be run in computer equipment as shown in FIG. 6.It can be deposited in the memory of computer equipment Each process template of the display device of storage composition digital pathological section.For example, obtaining module 502, splicing module 504 and generating Module 506.
A kind of computer equipment, including memory and processor, the memory are stored with computer program, the calculating When machine program is executed by the processor, so that the processor executes following steps:
The corresponding region pathological image set of pathological section each subregion is obtained, is wrapped in the region pathological image set Respective sub-areas is included in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathology The pathological section panoramic picture of slice;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.
Above-mentioned computer equipment, the first corresponding region pathological image set of acquisition pathological section each subregion, it is described It include region focus image of the respective sub-areas in different focus level in the pathological image set of region;Then from each area It selects a region focus image to be spliced in the pathological image set of domain, obtains the pathological section panorama sketch of the pathological section Picture;It finally obtains and repeatedly splices multiple obtained described pathological section panoramic pictures, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.As it can be seen that aforesaid way, since final digital pathological section is the side with animation The display that formula carries out, the mode of individual digital pathological section is shown compared to existing, the pathology that such mode is shown is cut Piece is due to showing the content of multiple digital pathological sections simultaneously, so more pathological section information can be shown, certain Disease is reduced in degree and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis, also, the pathological section that such mode is shown is single compared to only showing The mode of digital pathological section, closer to directly by way of micro- sem observation pathological section, also dropping to a certain extent Low disease fails to pinpoint a disease in diagnosis the risk with mistaken diagnosis.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
Obtain the clarity of each region focus image in each region pathological image set;
According to the clarity of each region focus image in the region pathological image set from each region pathology A region focus image is selected to be spliced in image collection.
When the computer program is executed by the processor in one of the embodiments, it is also used to:
It is obtained in each region pathological image set after the clarity of each region focus image described, The clarity of each region focus image in each region pathological image set is ranked up, each institute is obtained State the ranking results of the clarity of region focus image;
The clarity according to each region focus image in the region pathological image set is from each region A region focus image is selected to be spliced in pathological image set, comprising:
According to the ranking results of the clarity of the region focus image each in the region pathological image set, from every The highest region focus image of a clarity is selected in the image of unselected mistake in a region pathological image set Spliced.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
The region focus image of an identical focusing level is respectively selected to carry out from each region pathological image set Splicing;
Described multiple pathological section panoramic pictures according to generate pathological section animated image and show, comprising:
Pathological section animated image is generated according to the corresponding focusing level of multiple described pathological section panoramic pictures and is shown.
Described multiple pathological section panoramic pictures according to generate pathological section animation figure in one of the embodiments, Picture, comprising:
It scores the picture quality of multiple pathological section panoramic pictures, obtains every pathological section panorama The appraisal result of image;
According to the appraisal result of pathological section panoramic picture described in every, the aobvious of corresponding pathological section panoramic picture is determined Show duration;
Pathological section animated image is generated according to the display duration of each pathological section panoramic picture.
The appraisal result according to pathological section panoramic picture described in every in one of the embodiments, determining pair The display duration for the pathological section panoramic picture answered, comprising:
It obtains score value and shows the mapping table of duration, according to the appraisal result of pathological section panoramic picture described in every The display duration of corresponding pathological section panoramic picture is determined with the mapping table, score value and aobvious in the mapping table Grow up to inverse correlation when showing.
In one embodiment it is proposed that a kind of computer readable storage medium, is stored with computer program, the calculating When machine program is executed by processor, so that the processor executes following steps:
The corresponding region pathological image set of pathological section each subregion is obtained, is wrapped in the region pathological image set Respective sub-areas is included in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathology The pathological section panoramic picture of slice;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, according to multiple described pathological section panorama sketch As generating pathological section animated image and showing.
Above-mentioned computer readable storage medium, the first corresponding region pathological image collection of acquisition pathological section each subregion It closes, includes region focus image of the respective sub-areas in different focus level in the region pathological image set;Then from every A region focus image is selected to be spliced in a region pathological image set, the pathology for obtaining the pathological section is cut Piece panoramic picture;It finally obtains and repeatedly splices multiple obtained described pathological section panoramic pictures, cut according to multiple described pathology Piece panoramic picture generates pathological section animated image and shows.As it can be seen that aforesaid way, due to final digital pathological section be with The display that the mode of animation carries out shows that the mode of individual digital pathological section, such mode are shown compared to existing Pathological section due to showing the content of multiple digital pathological sections simultaneously, so more pathological sections letter can be shown Breath reduces disease to a certain extent and fails to pinpoint a disease in diagnosis risk with mistaken diagnosis, also, the pathological section that shows of such mode compared to The mode for only showing individual digital pathological section, closer to directly by way of micro- sem observation pathological section, also certain Disease is reduced in degree fails to pinpoint a disease in diagnosis risk with mistaken diagnosis.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
Obtain the clarity of each region focus image in each region pathological image set;
According to the clarity of each region focus image in the region pathological image set from each region pathology A region focus image is selected to be spliced in image collection.
When the computer program is executed by the processor in one of the embodiments, it is also used to:
It is obtained in each region pathological image set after the clarity of each region focus image described, The clarity of each region focus image in each region pathological image set is ranked up, each institute is obtained State the ranking results of the clarity of region focus image;
The clarity according to each region focus image in the region pathological image set is from each region A region focus image is selected to be spliced in pathological image set, comprising:
According to the ranking results of the clarity of the region focus image each in the region pathological image set, from every The highest region focus image of a clarity is selected in the image of unselected mistake in a region pathological image set Spliced.
It is described in one of the embodiments, that a region focusing figure is selected from each region pathological image set As being spliced, comprising:
The region focus image of an identical focusing level is respectively selected to carry out from each region pathological image set Splicing;
Described multiple pathological section panoramic pictures according to generate pathological section animated image and show, comprising:
Pathological section animated image is generated according to the corresponding focusing level of multiple described pathological section panoramic pictures and is shown.
Described multiple pathological section panoramic pictures according to generate pathological section animation figure in one of the embodiments, Picture, comprising:
It scores the picture quality of multiple pathological section panoramic pictures, obtains every pathological section panorama The appraisal result of image;
According to the appraisal result of pathological section panoramic picture described in every, the aobvious of corresponding pathological section panoramic picture is determined Show duration;
Pathological section animated image is generated according to the display duration of each pathological section panoramic picture.
The appraisal result according to pathological section panoramic picture described in every in one of the embodiments, determining pair The display duration for the pathological section panoramic picture answered, comprising:
It obtains score value and shows the mapping table of duration, according to the appraisal result of pathological section panoramic picture described in every The display duration of corresponding pathological section panoramic picture is determined with the mapping table, score value and aobvious in the mapping table Grow up to inverse correlation when showing.
It should be noted that the display methods of above-mentioned digital pathological section, the display device of digital pathological section, computer Equipment and computer readable storage medium belong to a total inventive concept, the display methods of digital pathological section, digital pathology Content in the display device of slice, computer equipment and computer readable storage medium embodiment can be mutually applicable in.
Those of ordinary skill in the art will appreciate that realizing all or part of the process in above-described embodiment method, being can be with Relevant hardware is instructed to complete by computer program, the program can be stored in a non-volatile computer and can be read In storage medium, the program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein, provided herein Each embodiment used in any reference to memory, storage, database or other media, may each comprise non-volatile And/or volatile memory.Nonvolatile memory may include that read-only memory (ROM), programming ROM (PROM), electricity can be compiled Journey ROM (EPROM), electrically erasable ROM (EEPROM) or flash memory.Volatile memory may include random access memory (RAM) or external cache.By way of illustration and not limitation, RAM is available in many forms, such as static state RAM (SRAM), dynamic ram (DRAM), synchronous dram (SDRAM), double data rate sdram (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronization link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) directly RAM (RDRAM), straight Connect memory bus dynamic ram (DRDRAM) and memory bus dynamic ram (RDRAM) etc..
Each technical characteristic of above embodiments can be combined arbitrarily, for simplicity of description, not to above-described embodiment In each technical characteristic it is all possible combination be all described, as long as however, the combination of these technical characteristics be not present lance Shield all should be considered as described in this specification.
The several embodiments of the application above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously The limitation to the application the scope of the patents therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the concept of this application, various modifications and improvements can be made, these belong to the guarantor of the application Protect range.Therefore, the scope of protection shall be subject to the appended claims for the application patent.

Claims (12)

1. a kind of display methods of digital pathological section characterized by comprising
The corresponding region pathological image set of pathological section each subregion is obtained, includes phase in the region pathological image set Answer subregion in the region focus image of different focus level;
It selects a region focus image to be spliced from each region pathological image set, obtains the pathological section Pathological section panoramic picture;
Multiple obtained described pathological section panoramic pictures are repeatedly spliced in acquisition, raw according to multiple described pathological section panoramic pictures At pathological section animated image and show.
2. the method as described in claim 1, which is characterized in that described to select one from each region pathological image set Region focus image is opened to be spliced, comprising:
Obtain the clarity of each region focus image in each region pathological image set;
According to the clarity of each region focus image in the region pathological image set from each region pathological image A region focus image is selected to be spliced in set.
3. method according to claim 2, which is characterized in that obtained in each region pathological image set respectively described After the clarity of a region focus image, further includes:
The clarity of each region focus image in each region pathological image set is ranked up, is obtained each The ranking results of the clarity of a region focus image;
The clarity according to each region focus image in the region pathological image set is from each region pathology A region focus image is selected to be spliced in image collection, comprising:
According to the ranking results of the clarity of the region focus image each in the region pathological image set, from each institute It states and the highest region focus image of a clarity is selected to carry out in the image of the unselected mistake in the pathological image set of region Splicing.
4. the method as described in claim 1, which is characterized in that described to select one from each region pathological image set Region focus image is opened to be spliced, comprising:
The region focus image of an identical focusing level is respectively selected to be spliced from each region pathological image set;
Described multiple pathological section panoramic pictures according to generate pathological section animated image and show, comprising:
Pathological section animated image is generated according to the corresponding focusing level of multiple described pathological section panoramic pictures and is shown.
5. the method as described in claim 1, which is characterized in that described multiple pathological section panoramic pictures according to generate disease Reason slice animated image, comprising:
It scores the picture quality of multiple pathological section panoramic pictures, obtains every pathological section panoramic picture Appraisal result;
According to the appraisal result of pathological section panoramic picture described in every, when determining the display of corresponding pathological section panoramic picture It is long;
Pathological section animated image is generated according to the display duration of each pathological section panoramic picture.
6. method as claimed in claim 5, which is characterized in that the scoring according to pathological section panoramic picture described in every As a result, determining the display duration of corresponding pathological section panoramic picture, comprising:
It obtains score value and shows the mapping table of duration, according to the appraisal result of pathological section panoramic picture described in every and institute The display duration that mapping table determines corresponding pathological section panoramic picture is stated, when score value is with display in the mapping table Grow up to inverse correlation.
7. a kind of display device of digital pathological section characterized by comprising
Module is obtained, for obtaining the corresponding region pathological image set of pathological section each subregion, the region pathology figure Image set includes region focus image of the respective sub-areas in different focus level in closing;
Splicing module is obtained for selecting a region focus image to be spliced from each region pathological image set To the pathological section panoramic picture of the pathological section;
Generation module, for obtaining multiple the described pathological section panoramic pictures for repeatedly splicing and obtaining, according to multiple described pathology Slice panoramic picture generates pathological section animated image and shows.
8. device as claimed in claim 7, which is characterized in that the splicing module, comprising:
Clarity obtains module, for obtaining the clear of each region focus image in each region pathological image set Clear degree;
Clarity splicing module, for according to the clarity of each region focus image in the region pathological image set from every A region focus image is selected to be spliced in a region pathological image set.
9. device as claimed in claim 8, which is characterized in that described device further include:
Clarity sorting module, for the clear of each region focus image in each region pathological image set Clear degree is ranked up, and obtains the ranking results of the clarity of each region focus image;
The clarity splicing module, comprising: highest clarity splicing module, for according in the region pathological image set The ranking results of the clarity of each region focus image, from unselected in each region pathological image set The highest region focus image of a clarity is selected to be spliced in the image crossed.
10. device as claimed in claim 7, which is characterized in that the splicing module, comprising:
It is identical to focus layer splicing module, for respectively selecting an identical focusing level from each region pathological image set Region focus image spliced;
The generation module, comprising: it is identical to focus layer generation module, for corresponding according to multiple described pathological section panoramic pictures Focusing level generate and pathological section animated image and show.
11. a kind of computer equipment, which is characterized in that in the memory and can including memory, processor and storage The computer program run on the processor, which is characterized in that the processor is realized when executing the computer program As described in any one of claim 1 to 6 the step of the display methods of digital pathological section.
12. a kind of computer readable storage medium, the computer-readable recording medium storage has computer program, and feature exists In the display of realization digital pathological section as described in any one of claim 1 to 6 when the computer program is executed by processor The step of method.
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