CN109985270B - Preparation method of latex-free self-adhesive bandage - Google Patents
Preparation method of latex-free self-adhesive bandage Download PDFInfo
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- CN109985270B CN109985270B CN201910297245.8A CN201910297245A CN109985270B CN 109985270 B CN109985270 B CN 109985270B CN 201910297245 A CN201910297245 A CN 201910297245A CN 109985270 B CN109985270 B CN 109985270B
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- 239000000853 adhesive Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000243 solution Substances 0.000 claims abstract description 33
- 238000009987 spinning Methods 0.000 claims abstract description 32
- 239000000758 substrate Substances 0.000 claims abstract description 25
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 23
- 239000011259 mixed solution Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 21
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920002472 Starch Polymers 0.000 claims abstract description 21
- 239000008107 starch Substances 0.000 claims abstract description 21
- 235000019698 starch Nutrition 0.000 claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 229920002749 Bacterial cellulose Polymers 0.000 claims abstract description 8
- 239000005016 bacterial cellulose Substances 0.000 claims abstract description 8
- 238000002791 soaking Methods 0.000 claims abstract description 8
- 230000001954 sterilising effect Effects 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- 150000004676 glycans Chemical class 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
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- 239000005017 polysaccharide Substances 0.000 claims abstract description 7
- 238000005406 washing Methods 0.000 claims abstract description 7
- 239000003999 initiator Substances 0.000 claims abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 239000011347 resin Substances 0.000 claims description 13
- 229920005989 resin Polymers 0.000 claims description 13
- 238000001179 sorption measurement Methods 0.000 claims description 12
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- 229920001661 Chitosan Polymers 0.000 claims description 10
- 239000000835 fiber Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
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- 229920001451 polypropylene glycol Polymers 0.000 claims description 7
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 claims description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 6
- 238000003825 pressing Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 241001312219 Amorphophallus konjac Species 0.000 claims description 2
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 2
- 229920002498 Beta-glucan Polymers 0.000 claims description 2
- 229920001503 Glucan Polymers 0.000 claims description 2
- 229920002752 Konjac Polymers 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000000252 konjac Substances 0.000 claims description 2
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- 239000002245 particle Substances 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 abstract description 10
- 230000035699 permeability Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 238000001132 ultrasonic dispersion Methods 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract 1
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 5
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 4
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- 239000004826 Synthetic adhesive Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000001266 bandaging Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Nonwoven Fabrics (AREA)
Abstract
The invention discloses a preparation method of a latex-free self-adhesive bandage, which belongs to the technical field of bandage production, and the preparation method comprises the steps of mixing active biological polysaccharide, acrylic acid monomers, bacterial cellulose and other substances, heating after mixing, carrying out ultrasonic dispersion to obtain a spinning solution, carrying out electrostatic spinning on the spinning solution on the surface of a cotton-flax substrate to obtain a double-layer bandage substrate, preparing a starch solution, adding acrylic acid, adjusting the pH value to 8-9 to obtain a mixed solution, soaking the bandage substrate in the mixed solution, adding an initiator, heating to 45 ℃, carrying out heat preservation for 1-2 hours, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage. The double-sided self-adhesive bandage has good air permeability and elasticity, and has a water absorption effect.
Description
Technical Field
The invention relates to the technical field of bandage production, in particular to a preparation method of a self-adhesive bandage without latex.
Background
The bandage has wide application in real life, and different wounds are bandaged by different bandages. Self-adhesive elastic bandages are commonly used in various industries such as medical bandaging, industrial operation protection, field operation, sports protection and the like. The self-adhesive bandage is characterized in that a layer of adhesive is sprayed on the front surface and the back surface of a traditional medical bandage, the hand feeling is not obvious in adhesive sense, but the self-adhesive bandages are in contact (or are pressed with a certain force), so that the self-adhesive between materials can be formed, the bandage and the fixation are greatly facilitated, the air permeability is increased, and the skin pain sense after tearing is reduced. At present, natural latex or modified products thereof are mainly used as adhesives applied to self-adhesive elastic bandages at home and abroad, and due to the existence of protein in the natural latex, human skin is easy to be allergic, and the phenomena of putrefaction, mildewing and deterioration can be generated after the adhesives are placed for a long time, so that the researches on the self-adhesive bandages capable of replacing the natural latex have good social benefits and economic benefits and the adhesives have no allergy and good stability.
Although the synthetic adhesive self-adhesive elastic bandage does not contain soluble protein components, the manufacturing process of the synthetic adhesive self-adhesive elastic bandage has a solvent, the production process is controlled complicatedly, and meanwhile, the environmental pollution is caused. The self-adhesive bandage sold in the market at present is mostly obtained by blending cotton polyester and spandex, and has poor moisture and vapor permeability, so that the use comfort is poor.
Therefore, there is an urgent need to develop a latex-free self-adhesive bandage which has good air permeability and elasticity and has a water absorption effect.
Disclosure of Invention
The invention provides a preparation method of a self-adhesive elastic bandage without latex aiming at the defects in the prior art.
The invention is realized by the following method, and the specific operation steps comprise:
(1) respectively weighing 20-30 parts by weight of active biological polysaccharide, 3-5 parts by weight of acrylic acid monomer, 3-10 parts by weight of bacterial cellulose, 0.3-0.8 part by weight of polypropylene glycol, 5-10 parts by weight of N-N dimethylacetamide, 0.2-1.0 part by weight of macroporous adsorption resin powder, 0.01-0.03 part by weight of N, N-methylene bisacrylamide and 100-120 parts by weight of deionized water, and mixing;
further, the active biological polysaccharide is one or more of water-soluble chitosan, sodium alginate, hyaluronic acid, beta-glucan and konjac glucan.
Further, the water-soluble chitosan is carboxymethyl chitosan, the molecular weight is between 5 and 8 ten thousand, and the carboxyl degree is 0.38 to 0.50.
Further, the macroporous adsorption resin is AB-8 or D101; the particle size of the macroporous adsorption resin powder is 300-350 meshes.
(2) Ultrasonically dispersing for 30-60 min after mixing to form uniformly dispersed mixed liquid, namely spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment for electrostatic spinning, covering functional fibers on the surface of a cotton-flax substrate by an electrostatic spinning method, and pressing after spinning to obtain a bandage substrate;
further, the mass of the functional yarn is 40-60% of that of the cotton-flax substrate.
(3) Adding starch and Tween 60 into water to prepare a starch solution, adding acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 8-9, adjusting to obtain a mixed solution, soaking the bandage base material into the mixed solution, adding an initiator, gradually raising the temperature to 3-5 ℃ each time, keeping the temperature for 30-50 min each time, raising the temperature to 45 ℃, keeping the temperature for 1-2 h, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage.
Further, the mass ratio of the starch to the acrylic acid is 5-7: 1.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, the active biological polysaccharide, the acrylic acid monomer, the polypropylene glycol, the macroporous adsorption resin powder and other substances are heated to form the spinning solution, the active biological polysaccharide, the acrylic acid monomer, the bacterial cellulose and the like in the spinning solution are subjected to mutual crosslinking reaction, and the viscose solutions with different performances can be synthesized according to different use requirements. The spinning solution has good biocompatibility and excellent adhesion property to skin, the adhesion property can be adjusted, the added macroporous adsorption resin powder is uniformly dispersed, and the good air permeability and the water absorption property of the bandage can be obviously improved;
(2) under the action of electrostatic spinning, the functional fiber is subjected to crosslinking reaction, so that the formed functional fiber covers the surface of the cotton-flax substrate to obtain the bandage substrate, the bandage substrate has good flexibility and biocompatibility, has certain mechanical strength, and the viscose layer does not fall off and has certain antibacterial performance;
(3) preparing a starch solution, adding an acrylic acid monomer, adjusting the pH value to 8-9, wherein OH-in sodium hydroxide can reduce the stability of hydrogen bonds among starch molecules and weaken the cohesion of the molecules, so that the starch microscopically presents a lamellar shape, the hydroxyl in the starch solution is exposed to obtain a mixed solution, soaking a bandage base material in the mixed solution, and adding an initiator, wherein the starch can react with the acrylic acid monomer to generate a synergistic effect to enhance the adhesion of the bandage, and the mixed solution can react with the hydroxyl on the surface of the base material to further enhance the elasticity, the adhesion and the bonding strength of the self-adhesive bandage.
Detailed Description
The present invention will be described in more detail by way of examples, but the scope of the present invention is not limited to these examples.
Example 1
(1) Respectively weighing 20 parts of water-soluble chitosan with the molecular weight of about 5 ten thousand and the carboxyl degree of 0.38, 3 parts of acrylic acid monomer, 3 parts of bacterial cellulose, 0.8 part of polypropylene glycol, 5 parts of N-N dimethylacetamide, 1.0 part of 350-mesh macroporous adsorption resin powder, 0.01 part of N, N-methylene bisacrylamide AB-8 and 120 parts of deionized water, and mixing;
(2) mixing, performing ultrasonic dispersion for 30min to form uniformly dispersed mixed solution, namely spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment for electrostatic spinning, covering functional fibers on the surface of a cotton-flax substrate by an electrostatic spinning method, wherein the mass of the functional yarns is 40% of that of the cotton-flax substrate, and pressing after spinning to obtain a bandage substrate;
the parameters of the electrostatic spinning machine are spinning voltage: 15 kV; spinning temperature: room temperature; spinning humidity: 50 percent; receiving roller rotating speed: 80.0 m/min; receiving distance: 10cm.
(3) Adding 150g of starch and 1g of Tween 60 into 3000g of water to prepare a starch solution, then adding 30g of acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 8, obtaining a mixed solution after adjustment, soaking the bandage substrate in the mixed solution, then adding 0.3g of ammonium persulfate, gradually heating up to 3 ℃ each time, keeping the temperature for 30min each time, keeping the temperature for 1h after the temperature is increased to 45 ℃, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage.
Example 2
(1) Respectively weighing 25 parts of water-soluble chitosan with the molecular weight of about 6 ten thousand and the carboxyl degree of 0.42, 4 parts of acrylic acid monomer, 8 parts of bacterial cellulose, 5 parts of polypropylene glycol, 7 parts of N-N dimethylacetamide, 0.5 part of 350-mesh macroporous adsorption resin powder, 0.02 part of N, N-methylene bisacrylamide D101 and 100 parts of deionized water, and mixing;
(2) mixing and ultrasonically dispersing for 40min to form uniformly dispersed mixed solution, namely spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment for electrostatic spinning, covering functional fibers on the surface of a cotton-flax substrate by an electrostatic spinning method, and pressing after spinning to obtain a bandage substrate; the mass of the functional yarn is 50 percent of that of the cotton-flax substrate
The parameters of the electrostatic spinning machine are spinning voltage: 15 kV; spinning temperature: room temperature; spinning humidity: 50 percent; receiving roller rotating speed: 80.0 m/min; receiving distance: 10cm.
(3) Adding 180g of starch and 1g of Tween 60 into 3000g of water to prepare a starch solution, then adding 30g of acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 8, obtaining a mixed solution after adjustment, soaking the bandage substrate in the mixed solution, then adding 0.3g of ammonium persulfate, gradually heating up to 4 ℃ each time, keeping the temperature for 40min each time, keeping the temperature for 1.5h after the temperature is increased to 45 ℃, taking out after adjusting the pH value to be neutral, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage.
Example 3
(1) Respectively weighing 30 parts of water-soluble chitosan with the molecular weight of about 8 ten thousand and the carboxyl degree of 0.50, 5 parts of acrylic acid monomer, 10 parts of bacterial cellulose, 8 parts of polypropylene glycol, 5 parts of N-N dimethylacetamide, 1.0 part of 350-mesh macroporous adsorption resin powder, 0.03 part of N, N-methylene bisacrylamide AB-8 and 120 parts of deionized water, and mixing;
(2) mixing, ultrasonically dispersing for 60min to form uniformly dispersed mixed solution, namely spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment for electrostatic spinning, covering functional fibers on the surface of a cotton-flax substrate by an electrostatic spinning method, and pressing after spinning to obtain a bandage substrate; the mass of the functional yarn is 60 percent of that of the cotton-flax substrate
The parameters of the electrostatic spinning machine are spinning voltage: 15 kV; spinning temperature: room temperature; spinning humidity: 50 percent; receiving roller rotating speed: 80.0 m/min; receiving distance: 10cm.
(3) Adding 210g of starch and 1g of Tween 60 into 3000g of water to prepare a starch solution, then adding acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 9, adjusting to obtain a mixed solution, soaking the bandage base material into the mixed solution, then adding 0.3g of ammonium persulfate, gradually heating, raising the temperature to 5 ℃ each time, keeping the temperature for 50min each time, raising the temperature to 45 ℃, keeping the temperature for 2h, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage.
Comparative example 1
Comparative example 1 is different from example 1 in that: the functional fiber is not obtained by electrostatic spinning, and the rest steps are the same as the example 1
Adding 150g of starch and 1g of Tween 60 into 3000g of water to prepare a starch solution, then adding 30g of acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 8, obtaining a mixed solution after adjustment, soaking the bandage substrate in the mixed solution, then adding 0.3g of ammonium persulfate, gradually heating up to 3 ℃ each time, keeping the temperature for 30min each time, keeping the temperature for 1h after the temperature is increased to 45 ℃, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the self-adhesive bandage.
Comparative example 2
Comparative example 2 differs from example 1 in that: the procedure of example 1 was repeated except that the cotton-flax substrate was not immersed in the mixed solution.
(1) Respectively weighing 20 parts of water-soluble chitosan with the molecular weight of about 5 ten thousand and the carboxyl degree of 0.38, 3 parts of acrylic acid monomer, 3 parts of bacterial cellulose, 0.8 part of polypropylene glycol, 5 parts of N-N dimethylacetamide, 1.0 part of 350-mesh macroporous adsorption resin powder, 0.01 part of N, N-methylene bisacrylamide AB-8 and 120 parts of deionized water, and mixing;
(2) and ultrasonically dispersing for 30min after mixing to form uniformly dispersed mixed solution, namely spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment for electrostatic spinning, covering functional fibers on the surface of the cotton and linen base material by an electrostatic spinning method, and pressing after spinning to obtain the bandage.
Comparative example 3
Comparative example 3 differs from example 1 in that: in the same manner as in example 1 except that acrylic acid was not added in step (3) and the amount of starch was increased accordingly, a self-adhesive bandage was prepared.
Comparative example 4
Comparative example 4 is different from example 1 in that: the self-adhesive bandage was prepared in the same manner as in example 1 except that the macroporous adsorbent resin powder was not added in step (1).
The bandages prepared in the above examples were subjected to performance tests, the test results are shown in table 1:
table 1:
Claims (7)
1. a preparation method of a latex-free self-adhesive bandage is characterized by comprising the following steps: the specific preparation steps are as follows:
(1) respectively weighing 20-30 parts by weight of active biological polysaccharide, 3-5 parts by weight of acrylic acid, 3-10 parts by weight of bacterial cellulose, 0.3-0.8 part by weight of polypropylene glycol, 5-10 parts by weight of N-N dimethylacetamide, 0.2-1.0 part by weight of macroporous adsorption resin powder, 0.01-0.03 part by weight of N, N-methylene bisacrylamide and 100-120 parts by weight of deionized water;
(2) ultrasonically dispersing for 30-60 min after mixing, uniformly dispersing to obtain a spinning solution, injecting the spinning solution into an injector of electrostatic spinning equipment, covering functional fibers on the surface of a cotton-flax substrate by an electrostatic spinning method, spinning and pressing to obtain a bandage substrate;
(3) adding starch and Tween 60 into water to prepare a starch solution, adding acrylic acid, mixing, adding a sodium hydroxide solution to adjust the pH value to 8-9 to obtain a mixed solution, soaking the bandage base material into the mixed solution, adding an initiator, gradually heating to 3-5 ℃ each time, keeping the temperature for 30-50 min each time, continuing to keep the temperature for 1-2 h after the temperature is increased to 45 ℃, adjusting the pH value to be neutral, taking out, washing with water, drying, and sterilizing to obtain the double-sided self-adhesive bandage.
2. The method of making a latex-free self-adhesive bandage of claim 1, wherein: the active biological polysaccharide is one or more of water-soluble chitosan, sodium alginate, hyaluronic acid, beta-glucan and konjac glucan.
3. The method of preparing a latex-free self-adhesive bandage according to claim 2, wherein: the water-soluble chitosan is carboxymethyl chitosan, the molecular weight is between 5 and 8 ten thousand, and the carboxyl degree is 0.38 to 0.50.
4. The method of making a latex-free self-adhesive bandage of claim 1, wherein: the macroporous adsorption resin is AB-8 or D101; the particle size of the macroporous adsorption resin powder is 300-350 meshes.
5. The method of making a latex-free self-adhesive bandage of claim 1, wherein: the mass of the functional fiber is 40-60% of that of the cotton-flax substrate.
6. The method of making a latex-free self-adhesive bandage of claim 1, wherein: the mass ratio of the starch to the acrylic acid is 5-7: 1.
7. The method of making a latex-free self-adhesive bandage of claim 1, wherein: the irradiation dose of irradiation sterilization is 10-20 kGy.
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|---|---|---|---|---|
| US4306551A (en) * | 1980-07-28 | 1981-12-22 | Lectec Corporation | Sterile improved bandage and sealant |
| US20090149792A1 (en) * | 2007-12-06 | 2009-06-11 | Kreetech International Corp. | Composition for wound management |
| CN103611180A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN103611195A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN107802877A (en) * | 2017-11-14 | 2018-03-16 | 安徽斯麦特医学技术开发有限公司 | A kind of preparation method of self-adhesive medical elastic bandage |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306551A (en) * | 1980-07-28 | 1981-12-22 | Lectec Corporation | Sterile improved bandage and sealant |
| US20090149792A1 (en) * | 2007-12-06 | 2009-06-11 | Kreetech International Corp. | Composition for wound management |
| CN103611180A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN103611195A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN107802877A (en) * | 2017-11-14 | 2018-03-16 | 安徽斯麦特医学技术开发有限公司 | A kind of preparation method of self-adhesive medical elastic bandage |
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Denomination of invention: A preparation method for latex free self-adhesive bandages Granted publication date: 20210420 Pledgee: Su'ao Commercial Factoring (Jiangsu) Co.,Ltd. Pledgor: JIANGSU SOUTHERN EISAI PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980015563 |