CN109982698A - 治疗癌性肿瘤的方法 - Google Patents

治疗癌性肿瘤的方法 Download PDF

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Publication number
CN109982698A
CN109982698A CN201880003352.9A CN201880003352A CN109982698A CN 109982698 A CN109982698 A CN 109982698A CN 201880003352 A CN201880003352 A CN 201880003352A CN 109982698 A CN109982698 A CN 109982698A
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CN
China
Prior art keywords
chemotherapeutics
catheter device
dosage
radiotherapy
blood vessel
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Pending
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CN201880003352.9A
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English (en)
Chinese (zh)
Inventor
R·阿迦
K·纳伊马巴迪
S·R·巴盖
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RenovoRx Inc
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RenovoRx Inc
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Publication of CN109982698A publication Critical patent/CN109982698A/zh
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    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136Balloons
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    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880003352.9A 2017-05-18 2018-05-18 治疗癌性肿瘤的方法 Pending CN109982698A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762507962P 2017-05-18 2017-05-18
US62/507,962 2017-05-18
US15/807,011 US10695543B2 (en) 2017-05-18 2017-11-08 Methods for treating cancerous tumors
US15/807,011 2017-11-08
PCT/US2018/033482 WO2018213760A1 (en) 2017-05-18 2018-05-18 Methods for treating cancerous tumors

Publications (1)

Publication Number Publication Date
CN109982698A true CN109982698A (zh) 2019-07-05

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CN201880003352.9A Pending CN109982698A (zh) 2017-05-18 2018-05-18 治疗癌性肿瘤的方法

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US (1) US10695543B2 (enExample)
EP (1) EP3624794A1 (enExample)
JP (1) JP2020520992A (enExample)
CN (1) CN109982698A (enExample)
WO (1) WO2018213760A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10512761B2 (en) 2009-12-02 2019-12-24 Renovorx, Inc. Methods for delivery of therapeutic materials to treat pancreatic cancer
US9539081B2 (en) 2009-12-02 2017-01-10 Surefire Medical, Inc. Method of operating a microvalve protection device
US11020444B2 (en) * 2010-04-23 2021-06-01 Scicotec Gmbh Transluminal delivery of viruses for treatment of diseased tissue
US9968740B2 (en) 2014-03-25 2018-05-15 Surefire Medical, Inc. Closed tip dynamic microvalve protection device
US20160287839A1 (en) 2015-03-31 2016-10-06 Surefire Medical, Inc. Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment
US11400263B1 (en) 2016-09-19 2022-08-02 Trisalus Life Sciences, Inc. System and method for selective pressure-controlled therapeutic delivery
US10780250B1 (en) 2016-09-19 2020-09-22 Surefire Medical, Inc. System and method for selective pressure-controlled therapeutic delivery
US10588636B2 (en) 2017-03-20 2020-03-17 Surefire Medical, Inc. Dynamic reconfigurable microvalve protection device
US11052224B2 (en) 2017-05-18 2021-07-06 Renovorx, Inc. Methods for treating cancerous tumors
US12290564B2 (en) 2017-05-18 2025-05-06 Renovorx, Inc. Methods and apparatuses for treating tumors
CN111479571A (zh) * 2017-07-21 2020-07-31 瓦里安医疗系统公司 超高剂量率辐射和治疗剂的使用方法
US11850398B2 (en) 2018-08-01 2023-12-26 Trisalus Life Sciences, Inc. Systems and methods for pressure-facilitated therapeutic agent delivery
US11338117B2 (en) 2018-10-08 2022-05-24 Trisalus Life Sciences, Inc. Implantable dual pathway therapeutic agent delivery port
US12433597B2 (en) 2019-06-04 2025-10-07 Trisalus Life Sciences, Inc. Atraumatic occlusive system with compartment for measurement of vascular pressure change
EP4355418A1 (en) * 2021-06-14 2024-04-24 Novocure GmbH Methods of treating and preventing cancer with alternating electric fields, radioactive particles, and systemic therapy
WO2022265921A1 (en) * 2021-06-16 2022-12-22 Pulse Biosciences, Inc. Apparatus and method for delivering pulsed electric field therapy
US11911581B1 (en) 2022-11-04 2024-02-27 Controlled Delivery Systems, Inc. Catheters and related methods for the aspiration controlled delivery of closure agents
EP4611658A1 (en) 2022-11-04 2025-09-10 Solvein Inc. Catheters and related methods for aspiration and controlled delivery of closure agents
CN120529869A (zh) * 2022-11-11 2025-08-22 雷诺沃尔克斯股份有限公司 通过血管滋养管输送药剂的方法和装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140276135A1 (en) * 2009-12-02 2014-09-18 Renovorx, Inc. Devices, methods and kits for delivery of therapeutic materials to a pancreas

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4445892A (en) 1982-05-06 1984-05-01 Laserscope, Inc. Dual balloon catheter device
US4714460A (en) 1983-07-29 1987-12-22 Reynaldo Calderon Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4696304A (en) 1984-09-10 1987-09-29 Thomas J. Fogarty Thermodilution flow-directed catheter assembly and method
US4655746A (en) 1985-12-02 1987-04-07 Target Therapeutics Catheter device
JPH01207078A (ja) 1988-02-15 1989-08-21 Terumo Corp カテーテルチュブおよび内視鏡
US4830003A (en) 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5069662A (en) 1988-10-21 1991-12-03 Delcath Systems, Inc. Cancer treatment
DE69224187T2 (de) 1991-04-05 1998-08-06 Boston Scient Corp Konvertible kathetereinheit
US5281200A (en) 1992-12-08 1994-01-25 Cordis Corporation Multiple component balloon catheter system and stenosis treatment procedure
US5318535A (en) 1993-06-21 1994-06-07 Baxter International Inc. Low-profile dual-lumen perfusion balloon catheter with axially movable inner guide sheath
US6113576A (en) 1993-08-04 2000-09-05 Lake Region Manufacturing, Inc. Thrombolysis catheter system with fixed length infusion zone
US5338301A (en) 1993-08-26 1994-08-16 Cordis Corporation Extendable balloon-on-a-wire catheter, system and treatment procedure
US5462529A (en) 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5397307A (en) 1993-12-07 1995-03-14 Schneider (Usa) Inc. Drug delivery PTCA catheter and method for drug delivery
US5419763B1 (en) 1994-01-04 1997-07-15 Cor Trak Medical Inc Prostatic drug-delivery catheter
US5415636A (en) 1994-04-13 1995-05-16 Schneider (Usa) Inc Dilation-drug delivery catheter
US5484412A (en) 1994-04-19 1996-01-16 Pierpont; Brien E. Angioplasty method and means for performing angioplasty
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5836905A (en) 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration
US5833672A (en) 1994-12-12 1998-11-10 Nippon Zeon Co., Ltd. Double tube, balloon catheter produced by using double tube, and process for producing balloon catheter
CA2218105A1 (en) 1995-03-30 1996-10-03 Heartport, Inc. Endovascular cardiac venting catheter and method
US5833650A (en) 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
WO1997003715A1 (en) * 1995-07-21 1997-02-06 The General Hospital Corporation Method and apparatus of enhancing the delivery of a pharmaceutical formulation
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US6440097B1 (en) 1995-10-06 2002-08-27 Target Therapeutics, Inc. Balloon catheter with delivery side holes
JPH09117510A (ja) 1995-10-26 1997-05-06 Buaayu:Kk インフュージョンカテーテル
US5843050A (en) 1995-11-13 1998-12-01 Micro Therapeutics, Inc. Microcatheter
FR2748212B1 (fr) 1996-05-06 1998-07-31 Nycomed Lab Sa Catheter destine a la delivrance locale d'une substance therapeutiquement active
US6231544B1 (en) 1996-05-14 2001-05-15 Embol-X, Inc. Cardioplegia balloon cannula
US5833644A (en) 1996-05-20 1998-11-10 Percusurge, Inc. Method for emboli containment
US6270477B1 (en) 1996-05-20 2001-08-07 Percusurge, Inc. Catheter for emboli containment
US6022336A (en) 1996-05-20 2000-02-08 Percusurge, Inc. Catheter system for emboli containment
US6325826B1 (en) 1998-01-14 2001-12-04 Advanced Stent Technologies, Inc. Extendible stent apparatus
AU735395B2 (en) 1997-02-04 2001-07-05 Cook Urological Inc. Suprapubic drainage catheter
US5919135A (en) * 1997-02-28 1999-07-06 Lemelson; Jerome System and method for treating cellular disorders in a living being
US6176844B1 (en) 1997-05-22 2001-01-23 Peter Y. Lee Catheter system for the isolation of a segment of blood vessel
ATE267625T1 (de) 1997-06-23 2004-06-15 Schneider Europ Gmbh Katheteranordnung
US5919163A (en) 1997-07-14 1999-07-06 Delcath Systems, Inc. Catheter with slidable balloon
US5968012A (en) 1997-08-22 1999-10-19 Scimed Lifesystems, Inc. Balloon catheter with adjustable shaft
US20010041862A1 (en) 1997-09-02 2001-11-15 Morton G. Glickman Novel apparatus and method of treating a tumor in the extremity of a patient
US5961536A (en) 1997-10-14 1999-10-05 Scimed Life Systems, Inc. Catheter having a variable length balloon and method of using the same
US6375634B1 (en) * 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
US6699231B1 (en) 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6986788B2 (en) 1998-01-30 2006-01-17 Synthes (U.S.A.) Intervertebral allograft spacer
US6156053A (en) 1998-05-01 2000-12-05 Intella Interventional Systems, Inc. Dual catheter assembly
US6508777B1 (en) 1998-05-08 2003-01-21 Cardeon Corporation Circulatory support system and method of use for isolated segmental perfusion
US8177743B2 (en) 1998-05-18 2012-05-15 Boston Scientific Scimed, Inc. Localized delivery of drug agents
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
WO1999059666A1 (en) 1998-05-21 1999-11-25 The Government Of The United States Of America, Represented By The Secretary, Department Of The Health And Human Services Method for pressure mediated selective delivery of therapeutic substances and cannula
JPH11342208A (ja) 1998-06-02 1999-12-14 Buaayu:Kk バルーンカテーテル
US6083198A (en) 1998-06-25 2000-07-04 Cardiovention, Inc. Perfusion catheter providing segmented flow regions and methods of use
US6461327B1 (en) 1998-08-07 2002-10-08 Embol-X, Inc. Atrial isolator and method of use
US6165152A (en) 1998-09-11 2000-12-26 Advanced Cardiovascular Systems, Inc. Catheter with a flexible tip and taper and method of manufacture
US6051014A (en) 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6743196B2 (en) 1999-03-01 2004-06-01 Coaxia, Inc. Partial aortic occlusion devices and methods for cerebral perfusion augmentation
US6287290B1 (en) 1999-07-02 2001-09-11 Pulmonx Methods, systems, and kits for lung volume reduction
US6351663B1 (en) 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6575932B1 (en) 1999-12-02 2003-06-10 Ottawa Heart Institute Adjustable multi-balloon local delivery device
US6929633B2 (en) 2000-01-25 2005-08-16 Bacchus Vascular, Inc. Apparatus and methods for clot dissolution
US6482172B1 (en) 2000-02-09 2002-11-19 Jeffrey J. Thramann Flow-by channel catheter and method of use
US6346098B1 (en) 2000-03-07 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Methods and kits for locally administering an active agent to an interstitial space of a host
US6485500B1 (en) 2000-03-21 2002-11-26 Advanced Cardiovascular Systems, Inc. Emboli protection system
US6685672B1 (en) 2000-07-13 2004-02-03 Edwards Lifesciences Corporation Multi-balloon drug delivery catheter for angiogenesis
US6569146B1 (en) 2000-08-18 2003-05-27 Scimed Life Systems, Inc. Method and apparatus for treating saphenous vein graft lesions
US6692458B2 (en) 2000-12-19 2004-02-17 Edwards Lifesciences Corporation Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
US6436090B1 (en) 2000-12-21 2002-08-20 Advanced Cardiovascular Systems, Inc. Multi lumen catheter shaft
US7179251B2 (en) 2001-01-17 2007-02-20 Boston Scientific Scimed, Inc. Therapeutic delivery balloon
US6602241B2 (en) 2001-01-17 2003-08-05 Transvascular, Inc. Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
US7357794B2 (en) 2002-01-17 2008-04-15 Medtronic Vascular, Inc. Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
US6749581B2 (en) 2001-02-02 2004-06-15 Medtronic, Inc. Variable infusion rate catheter
EP2298220B1 (en) 2001-02-15 2016-06-08 Hansen Medical, Inc. Flexible instrument
US7766894B2 (en) 2001-02-15 2010-08-03 Hansen Medical, Inc. Coaxial catheter system
US6887227B1 (en) 2001-02-23 2005-05-03 Coaxia, Inc. Devices and methods for preventing distal embolization from the vertebrobasilar artery using flow reversal
US6520183B2 (en) 2001-06-11 2003-02-18 Memorial Sloan-Kettering Cancer Center Double endobronchial catheter for one lung isolation anesthesia and surgery
US6682499B2 (en) 2001-06-28 2004-01-27 Jay Alan Lenker Method and apparatus for venous drainage and retrograde coronary perfusion
US6706013B1 (en) 2001-06-29 2004-03-16 Advanced Cardiovascular Systems, Inc. Variable length drug delivery catheter
US6533800B1 (en) 2001-07-25 2003-03-18 Coaxia, Inc. Devices and methods for preventing distal embolization using flow reversal in arteries having collateral blood flow
US7452532B2 (en) 2001-09-30 2008-11-18 Scicotec Gmbh Transluminal application of adult stem cells for body organ tissue repair
EP1469902A4 (en) 2002-02-01 2006-08-23 Robert J Goldman MULTIFUNCTIONAL CATHETER AND ITS USE
US8062251B2 (en) 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
US7503904B2 (en) 2002-04-25 2009-03-17 Cardiac Pacemakers, Inc. Dual balloon telescoping guiding catheter
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20050015048A1 (en) 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
US20050059931A1 (en) 2003-09-16 2005-03-17 Venomatrix Methods and apparatus for localized and semi-localized drug delivery
US20050059930A1 (en) 2003-09-16 2005-03-17 Michi Garrison Method and apparatus for localized drug delivery
JP3877075B2 (ja) 2004-01-28 2007-02-07 有限会社エスアールジェイ 内視鏡装置
CN1937976B (zh) 2004-02-02 2011-12-07 孕体有限公司 一种用于避孕的增强组织向内生长的装置
US7815624B2 (en) 2004-05-18 2010-10-19 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
WO2006053119A1 (en) 2004-11-12 2006-05-18 Regents Of The University Of Minnesota A veinous occlusion device and methods of using
US7947030B2 (en) 2004-12-30 2011-05-24 Reynaldo Calderon Retrograde perfusion of tumor sites
US8721592B2 (en) 2006-01-25 2014-05-13 Thermopeutix, Inc. Variable length catheter for drug delivery
US7789846B2 (en) 2005-01-25 2010-09-07 Thermopeutix, Inc. System and methods for selective thermal treatment
US7708715B2 (en) 2005-03-21 2010-05-04 Boston Scientific Scimed, Inc. Tissue approximation device
US7515957B2 (en) 2005-06-23 2009-04-07 Medtronic Vascular, Inc. Catheter-based, dual balloon photopolymerization system
US20090018526A1 (en) 2005-08-25 2009-01-15 John Melmouth Power Devices and Methods for Perfusing an Organ
DE102005042338B4 (de) 2005-09-06 2007-07-05 Siemens Ag Kathetereinrichtung
US8172792B2 (en) 2005-12-27 2012-05-08 Tyco Healthcare Group Lp Embolic protection systems for bifurcated conduits
WO2007081842A2 (en) 2006-01-09 2007-07-19 University Of Virginia Patent Foundation Multi-port catheter system with medium control and measurement systems for therapy and diagnosis delivery
US8177829B2 (en) 2006-08-23 2012-05-15 Boston Scientific Scimed, Inc. Auxiliary balloon catheter
EP2104468A2 (en) 2007-01-08 2009-09-30 Gross, Yossi In-situ filter
JP2009034462A (ja) 2007-07-31 2009-02-19 Koosei Advance:Kk 膵臓治療用灌流システム
US8182446B2 (en) 2007-09-12 2012-05-22 Cook Medical Technologies Balloon catheter for delivering a therapeutic agent
EP2211936B1 (en) 2007-11-07 2014-07-16 LANE, Rodney James Systems and devices for circulatory access
US8043257B2 (en) 2007-12-06 2011-10-25 Abbott Cardiovascular Systems Inc. Agent delivery catheter having an inflation bridge between two axially spaced balloons
US20090198093A1 (en) * 2008-02-06 2009-08-06 Oliver Meissner System and method for combined embolization and ablation therapy
EP2110151A1 (en) 2008-04-16 2009-10-21 Edward Diethrich Double balloon occlusion device
US20090275918A1 (en) 2008-05-01 2009-11-05 Stemcor Systems, Inc. Pancreatic delivery catheter
AU2009293312B2 (en) 2008-09-18 2015-07-09 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8162879B2 (en) 2008-09-22 2012-04-24 Tyco Healthcare Group Lp Double balloon catheter and methods for homogeneous drug delivery using the same
EP3093039A1 (en) 2008-11-03 2016-11-16 Advanced Catheter Therapies, Inc. Occlusion perfusion catheter
US8540667B2 (en) 2008-11-12 2013-09-24 Sanovas, Inc. Multi-balloon catheter for extravasated drug delivery
US8444624B2 (en) 2009-10-19 2013-05-21 Vatrix Medical, Inc. Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections
US10512761B2 (en) 2009-12-02 2019-12-24 Renovorx, Inc. Methods for delivery of therapeutic materials to treat pancreatic cancer
US20160082178A1 (en) 2009-12-02 2016-03-24 Renovorx, Inc. Angiographic methods for identification of feeder vessels
US8821476B2 (en) 2009-12-02 2014-09-02 Renovorx, Inc. Devices, methods and kits for delivery of therapeutic materials to a pancreas
WO2011127392A2 (en) 2010-04-08 2011-10-13 BiO2 Medical, Inc. Catheter hub
CA2826760A1 (en) 2011-02-08 2012-08-16 Advanced Bifurcation Systems, Inc. Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use
US8597239B2 (en) 2011-03-01 2013-12-03 Sanovas, Inc. Abrading balloon catheter for extravasated drug delivery
US9180281B2 (en) 2011-04-08 2015-11-10 Sanovas, Inc. Adjustable balloon catheter for extravasated drug delivery
US8702678B2 (en) 2011-08-03 2014-04-22 Venous Therapy, Inc. Assemblies, systems, and methods for infusing therapeutic agents into the body
US20140214002A1 (en) 2013-01-27 2014-07-31 Thermopeutix, Inc. Bifurcation catheter with variable length occlusion elements
HK1219909A1 (zh) * 2013-05-08 2017-04-21 Embolx, Inc. 使用整合流量调节之用於经由血管之肿瘤栓塞之装置及方法
WO2014197362A1 (en) 2013-06-03 2014-12-11 Ramtin Agah Devices, methods and kits for delivery of therapeutic materials to a pancreas
WO2015100393A1 (en) * 2013-12-27 2015-07-02 Renalpro Medical, Inc. Devices and methods for treating acute kidney injury
WO2016011328A1 (en) 2014-07-17 2016-01-21 Baker Cheryl Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent
CN113040895A (zh) * 2014-10-30 2021-06-29 纽敦力公司 治疗多种疾病的化学消融和方法
US9889120B2 (en) 2016-01-14 2018-02-13 Vicus Therapeutics, Llc Combination drug therapies for cancer and methods of making and using them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140276135A1 (en) * 2009-12-02 2014-09-18 Renovorx, Inc. Devices, methods and kits for delivery of therapeutic materials to a pancreas

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANAND MAHADEVAN等: "STEREOTACTIC BODY RADIOTHERAPYAND GEMCITABINE FOR LOCALLY ADVANCED PANCREATIC CANCER", 《INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS》 *
无: "RenovoRx Release: Researchers Report Survival Benefits With Use Of RenovoCath In Patients With Locally Advanced Pancreatic Tumors", 《HTTPS://WWW.BIOSPACE.COM/ARTICLE/RELEASES/RENOVORX-RELEASE-RESEARCHERS-REPORT-SURVIVAL-BENEFITS-WITH-USE-OF-RENOVOCATH-IN-PATIENTS-WITH-LOCALLY-ADVANCED-PANCREATIC-TUMORS-/》 *

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