CN109971631A - It is a kind of to carry out vaccine preparation method using aquiculture animal bacterial vaccine device - Google Patents
It is a kind of to carry out vaccine preparation method using aquiculture animal bacterial vaccine device Download PDFInfo
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- CN109971631A CN109971631A CN201910272834.0A CN201910272834A CN109971631A CN 109971631 A CN109971631 A CN 109971631A CN 201910272834 A CN201910272834 A CN 201910272834A CN 109971631 A CN109971631 A CN 109971631A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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Abstract
Vaccine preparation method is carried out using aquiculture animal bacterial vaccine device the invention discloses a kind of, wherein, the aquiculture animal bacterial vaccine device includes incubator, a desinfection chamber is provided in the incubator, a driving mechanism is provided in the desinfection chamber, the driving mechanism includes l-shaped rod, limiting slot, corner block and power supply box, the power supply box works as power source drive whole device, it drives the l-shaped rod to rotate by the limiting slot and the stuck of the corner block, is provided with a swaying mechanism on the upside of the driving mechanism;Present apparatus structure is simple, bacterium cultivates the manufacturing process of bottle in the carry out production of vaccine that can be automated, plant automation degree is higher, the place that seldom manpower participates in, while saving labour, also it reduces human body and carries the possibility that bacterium is mixed into culture bottle, ensure the quality of vaccine, and this device is suitable for mass production, whole device only uses a power source, whole transmission efficiency is higher, and energy utilization rate is higher.
Description
Technical field
It is specially a kind of to carry out vaccine preparation using aquiculture animal bacterial vaccine device the present invention relates to field of medicaments
Method.
Background technique
Vaccine is the medical article for being used to prevent certain disease for utilizing all kinds of pathogenic microorganism production, in aquaculture
In, common vaccine has vibrios disease vaccine etc., in the manufacturing process of vaccine, requires first to carry out culture breeding to pathogen,
To obtain more products, and currently available vaccines, existing vaccines culture manpower participates in very much, if the degree of disinfection of people is inadequate, it is more likely that mixed
Enter impurity, and more demanding to operating, the labour needed is more.
Summary of the invention
Vaccine preparation method is carried out using aquiculture animal bacterial vaccine device the purpose of the present invention is to provide a kind of,
To solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme: a kind of filled using aquiculture animal bacterial vaccine
Set carry out vaccine preparation method, wherein the aquiculture animal bacterial vaccine device includes incubator, setting in the incubator
Have a desinfection chamber, be provided with a driving mechanism in the desinfection chamber, the driving mechanism include l-shaped rod, limiting slot, corner block with
Power supply box, the power supply box work as power source drive whole device, pass through the stuck of the limiting slot and the corner block
The l-shaped rod can be driven to rotate, the driving mechanism further includes temperature slot and movable block, is provided with one on the upside of the driving mechanism
Swaying mechanism, the swaying mechanism include culture bottle and heat conducting bar, the heat conducting bar heat of the culture bottle can be conducted to
In the temperature slot, so that the movable block be driven to move downward, the swaying mechanism further includes arc block, vertical slots and ring
Slot can stop the rotation of the l-shaped rod when the arc block is located in the vertical slots, so that the corner block is detached from
The blocking of the limiting slot, when the arc block is located in annular groove, the l-shaped rod can drive the arc block in the annular groove
Interior rotation, the swaying mechanism further include ring block, and after the ring block declines a distance, the arc block just be can enter
In the annular groove, the driving mechanism further includes rack gear block, is provided with a drainage mechanism, the drain on the right side of the swaying mechanism
Mechanism includes two-way gear, ratchet wheel block, drain block and sump pit, can only be pushed when the rack gear block moves the drain block to
Bacterium liquid in the sump pit is discharged into the culture bottle by left movement, and only when the ring block rises, the release link can
It pushes the drain block to move right, carries out the filling of next bacterium liquid, the drainage mechanism further includes two check valves, described
Flow direction of the check valve to control bacterium liquid;
Being technically characterized in that when the culture bottle reaches certain temperature for this method, may make the driving mechanism energization work
Make, when the culture bottle reaches certain mass, the arc block can be detached from the stuck of the vertical slots and enter the annular groove,
By the barrier effect of the corner block and the limiting slot, the arc block can be driven to move in the annular groove, thus right
Culture bottle is uniformly rocked, and when the culture bottle temperature reduces, the rack gear block can drive the drain block to transport to the left
It is dynamic, Quantifying Bacteria liquid is added into the culture bottle.
Preferably, the driving mechanism includes corner block, the desinfection chamber lower end wall is rotatably connected to a drive shaft, institute
It states and is provided with a hollow block in drive shaft, the cylindrical groove that about one end wall is connected to the desinfection chamber is provided in the hollow block,
The drive shaft upper end is through end wall above and below the cylindrical groove and is located in the desinfection chamber, and the drive shaft upper end is fixedly connected
The driving motor for thering is a rear end face to be fixedly connected with the desinfection chamber aft bulkhead, it is set in drive shaft left side in the cylindrical groove
It is equipped with the limiting slot that a left end wall is connected to the cylindrical groove, a right end wall is provided in the cylindrical groove left side and is connected to the column
The elastic groove of shape slot, elastic groove left end wall are fixedly connected with an elastomeric spring, and the elastomeric spring right end is fixedly connected with
One right end through the elastic groove right end wall and limiting slot left end wall and the corner block that is located in the limiting slot, it is described in
Empty block left side is fixedly connected with a l-shaped rod, and the desinfection chamber aft bulkhead is fixedly connected with a power supply box, the power supply box right end
It is provided with the socket that a right end wall is connected to the desinfection chamber in face, is provided with one and the desinfection chamber rear end on the right side of the power supply box
The temperature block that wall is fixedly connected is provided with a temperature slot in the temperature block, is fixedly connected with a stopper in the temperature slot,
It is provided with a movable block being slidably connected with the temperature slot on the right side of the stopper, a left side is fixedly connected on the movable block
Right end extends through the temperature slot left hand end wall and is located at the sterile indoor stock, fixed on the right side of the stock upper surface
It is connected with a rack gear block, the stock left end is fixedly connected with a supporting block, and the supporting block left side is fixedly connected with one and inserts
Head, the supporting block are fixedly connected with the driving motor by electric wire;
It is characterized by: gas expansion in the temperature slot, so that the movable block is pushed to move downward, the movable block
The stock is driven to move downward, the stock drives the plug to move downward with the rack gear block, and the rack gear block drives
The two-way gear rotates clockwise a distance, to open the driving motor, to drive the drive shaft turns, leads to
The blocking of the corner block Yu the limiting slot is crossed, the drive shaft drives the l-shaped rod rotation.
Preferably, the drainage mechanism includes oscillating rod, a torsional channel is provided in the desinfection chamber aft bulkhead, it is described
Torsional channel aft bulkhead is rotatably connected to a front end through the torsional channel front bulkhead and is located at the sterile indoor torque axis, institute
It states and is provided with a torsion spring between torque axis and the torsional channel, be fixedly connected with a bi-directional teeth on the desinfection chamber internal torque axis
Wheel, the two-way gear front side are provided with an oscillating rod being fixedly connected with the torque axis, and the desinfection chamber aft bulkhead is solid
Surely it is connected with a storage block, a seal groove is provided in the storage block, is provided with an input slot in the seal groove aft bulkhead,
It is provided with a sump pit in the seal groove lower end wall, slidably connects a drain block in the sump pit, on the drain block
One or so end is fixedly connected with to extend through the sump pit left hand end wall and be located at the sterile indoor two-way bar, it is described double
Be fixedly connected with an infusion block to bar left end, the two-way bar right end is fixedly connected with a drain block, the seal groove with it is described
Sump pit is connected by medial launder, and a check valve is provided in the medial launder, and the medial launder left side is fixedly connected with
One perfusion tube, sump pit left end wall are provided with the output magazine of the connection perfusion tube and the sump pit, the output
A check valve is provided in slot, the desinfection chamber aft bulkhead is fixedly connected with a positioning block, and the locating piece right side rotation connects
It is connected to a locating shaft, the locating shaft right end is fixedly connected with a ratchet wheel block, and a ratchet slot is provided in the ratchet wheel block, described
A ratchet shaft is provided on the right side of locating shaft, the ratchet shaft left end is through the ratchet slot right end wall and is located at the ratchet slot
Interior, the ratchet shaft left end is fixedly connected with a ratchet, and end wall is symmetrically fixedly connected with a bottom biock, institute to the ratchet slot up and down
It states in the bottom biock lower end surface of upside and is provided with the base channel that a lower end wall is connected to the ratchet slot, the base channel upper end wall is fixed
Be connected with a bottom spring, the bottom lower spring end be fixedly connected with a lower end through the base channel lower end wall and with it is described
The elastic force block of ratchet Contact Transmission connection, the ratchet shaft right end are fixedly connected with a drive bevel gear, the locating piece rear end
Wall is rotatably connected to a rotary shaft, and a left end and drive bevel gear rear end engaged transmission are fixedly connected in the rotary shaft
The rotation bevel gear of connection, the rotation bevel gear rear side are provided with a release link being fixedly connected with the rotary shaft;
It is characterized by: the two-way gear rotates counterclockwise, so that the torque axis be driven to rotate, the torque axis drives institute
Oscillating rod rotation is stated, the oscillating rod pushes the drain block to move downward, so that the two-way bar is driven to move downward, it is described
Two-way bar drives the drain block to move downward, so that the bacterium liquid in the drain block is discharged by the perfusion tube.
Preferably, the swaying mechanism includes heat conducting bar, the desinfection chamber aft bulkhead is fixedly connected with a support plate, institute
The heat conducting bar for being embedded in support plate and holding and being located in the temperature slot is stated, the desinfection chamber aft bulkhead is fixedly connected with one and puts
Block is set, is provided with the bilateral slot that about one end wall is connected to the desinfection chamber in the placement block, the placement block is set in upper surface
It is equipped with the gravity-feed tank that a upper end wall is connected to the desinfection chamber, right end wall connection institute is provided in the end wall of the gravity-feed tank leftmost side
The square groove of gravity-feed tank is stated, a upper end is slidably connected in the gravity-feed tank through the gravity-feed tank upper end wall and is located at the nothing
The indoor ring block of bacterium, the upper surface are placed with a culture bottle, and upper end wall connection is provided in the culture bottle upper surface
A rear end face and ratchet wheel block engaged transmission are fixedly connected on rear side of ring block upper surface described in the culture tank of the desinfection chamber
The extension bar of connection, the ring block lower end surface are fixedly connected with the gravity-feed tank upper end wall by six gravity springs.It is described
The electromagnetism slot that a right end wall is connected to the gravity-feed tank is provided in ring block, electromagnetism slot left end wall is fixedly connected with an electromagnetism
Spring, the electromagnetic spring right end are fixedly connected with a right end through the electromagnetism slot right end wall and are located in the gravity-feed tank
Electromagnetic block;
Wherein, the stuck slot that a left end wall is connected to the gravity-feed tank, the stuck slot right end wall are provided on the right side of the square groove
It is fixedly connected with a magnet, the square groove lower end wall is provided with the shifting chute that a upper end wall is connected to the square groove, the shifting
Dynamic slot left end wall is fixedly connected with a mobile spring, and the mobile spring right end is fixedly connected with one and connects with shifting chute sliding
The movable block connect, the movable block upper surface are fixedly connected with a upper end through the shifting chute upper end wall and are located at described rectangular
Mobile bar in slot, the mobile bar upper end are fixedly connected with a circular cone, are provided with one and the side on the right side of the circular cone
The jackshaft of shape slot aft bulkhead rotation connection, is fixedly connected with a right end budget statement ring block left end face on the jackshaft and nibbles
The intermediate gear of transmission connection is closed, is provided with the rotation that a lower end wall is connected to the square groove in the intermediate gear lower end surface
Slot, the circular cone upside are provided with the drawstring axis of one with desinfection chamber aft bulkhead rotation connection, fix on the drawstring axis
It is connected with the drawstring gear that a lower end and the circular cone upper surface are connected by meshing transmission, is provided in the square groove upper end wall
One upper end wall is connected to the annular groove of the desinfection chamber, and a vertical slots, the vertical slots are provided between the annular groove and the square groove
It is provided with a movement slots in the wall of left end, a moving mass is slidably connected in the movement slots, the moving mass lower end surface is fixed to be connected
It is connected to the movement spring that a lower end is fixedly connected with the movement slots lower end wall, the moving mass right side is fixedly connected with a right side
End is through the movement slots right end wall and the moving lever in the vertical slots, the moving lever right end are fixedly connected with one liter
Block drops, and the elevator lower end surface is fixedly connected with the drawstring axis by fly rope, is provided with one on the upside of the elevator
The arc block being slidably connected with the vertical slots, the arc block upper surface are fixedly connected with a upper end through the annular groove and position
In it is described it is sterile it is indoor rock bar, it is described to be located at sterile indoor bar left side of rocking and be fixedly connected with a swingle;
It is characterized by: the power supply box is opened, the agar culture of the certain temperature after heating disinfection is added toward the culture tank
Liquid, the culture bottle quality increase, to press the ring block decline, the ring block is driven under the extension bar
Drop drives the ratchet wheel block to rotate by the engaged transmission of the extension bar and the ratchet wheel block, described in the ratchet wheel block drive
The rotation of elastic force block, under the rotation in this direction, the elastic force block does not drive the ratchet wheel, when agar culture solution is added to one
When determining degree, the electromagnetic block moves to the stuck groove location with ring block, and the electromagnetic spring resets to the right, described in drive
Electromagnetic block enters stuck in the stuck slot, and the gravity spring is compressed, and the ring block and the intermediate gear are passed through
Engaged transmission drives the intermediate gear to rotate, until the swivelling chute moves at the circular cone, the mobile spring is to the right
It resets, the circular cone is driven to enter in the swivelling chute, pass through the engaged transmission of the circular cone and the drawstring gear, band
The drawstring gear rotation is moved, so that the drawstring axis be driven to rotate, the drawstring axis loosens the fly rope, the movement
Spring resets upwards, to drive the elevator to reset upwards, so that the arc block is released the vertical slots simultaneously upwards
Into in the annular groove, bar is rocked described in the arc block drive and rises the jack-up left side culture bottle.
In conclusion the medicine have the advantages that present apparatus structure is simple, bacterium in the carry out production of vaccine that can be automated
The manufacturing process of bottle is cultivated, plant automation degree is higher, the place that seldom manpower participates in, while saving labour,
It reduces human body and carries the possibility that bacterium is mixed into culture bottle, it is ensured that the quality of vaccine, and this device is in one vaccine training of production
Next production can be carried out after supporting bottle, it is suitable for mass production, Production Time is saved, whole device has only used a power
Source, whole transmission efficiency is higher, and energy utilization rate is higher.
Detailed description of the invention
Below with reference to Fig. 1-4, the present invention is described in detail, wherein for sake of convenience, now to hereafter described orientation
Provide as follows: hereafter described front-rear direction up and down is consistent with the front-rear direction up and down of Fig. 1 projection relation itself.
Fig. 1 is the schematic view of the front view of aquiculture animal bacterial vaccine device entirety complete section of the present invention;
Fig. 2 is intermediate gear enlarged structure schematic diagram in aquiculture animal bacterial vaccine device of the present invention;
Fig. 3 is ratchet wheel block schematic diagram of main cross-sectional structure in aquiculture animal bacterial vaccine device of the present invention;
Fig. 4 is that torque axis overlooks schematic cross-sectional view in aquiculture animal bacterial vaccine device of the present invention.
Specific embodiment
All features disclosed in this specification or disclosed all methods or in the process the step of, in addition to mutually exclusive
Feature and/or step other than, can combine in any way.
Any feature disclosed in this specification (including any accessory claim, abstract and attached drawing), except non-specifically chatting
It states, can be replaced by other alternative features that are equivalent or have similar purpose.That is, unless specifically stated, each feature is only
It is an example in a series of equivalent or similar characteristics.
Please refer to Fig. 1-4, a kind of embodiment provided by the invention: it is a kind of using aquiculture animal bacterial vaccine device into
Row vaccine preparation method, wherein the aquiculture animal bacterial vaccine device includes incubator 100, is set in the incubator 100
It is equipped with a desinfection chamber 101, a driving mechanism 200 is provided in the desinfection chamber 101, the driving mechanism 200 includes l-shaped rod
103, limiting slot 146, corner block 148 and power supply box 104, the power supply box 104 work as power source drive whole device, lead to
It crosses the limiting slot 146 and drives the l-shaped rod 103 to rotate with the stuck of the corner block 148, the driving mechanism 200 is also
Including temperature slot 140 and movable block 142, a swaying mechanism 202, the swaying mechanism are provided on the upside of the driving mechanism 200
202 include culture bottle 106 and heat conducting bar 141, and the heat conducting bar 141 can conduct the heat of the culture bottle 106 to the temperature
It spends in slot 140, so that the movable block 142 be driven to move downward, the swaying mechanism 202 further includes arc block 160, vertical slots
164 with annular groove 161, the rotation of the l-shaped rod 103 can be stopped when the arc block 160 is located in the vertical slots 164, from
And the corner block 148 is made to be detached from the blocking of the limiting slot 146, and when the arc block 160 is located in annular groove 161, institute
Stating l-shaped rod 103 can drive the arc block 160 to rotate in the annular groove 161, and the swaying mechanism 202 further includes ring block
165, after the ring block 165 declines a distance, the arc block 160 just be can enter in the annular groove 161, the driving
Mechanism 200 further includes rack gear block 137, and a drainage mechanism 201, the drainage mechanism 201 are provided on the right side of the swaying mechanism 202
Including two-way gear 136, ratchet wheel block 112, drain block 128 and sump pit 129, can only be pushed when the rack gear block 137 moves
The drain block 128 moves downward, and bacterium liquid in the sump pit 129 is discharged into the culture bottle 106, only when the annular
When block 165 rises, the release link 116 can push the drain block 128 to move right, and carry out the filling of next bacterium liquid, institute
Stating drainage mechanism 201 further includes two check valves 122, flow direction of the check valve 122 to control bacterium liquid.
Valuably, the driving mechanism 200 includes corner block 148, and 101 lower end wall of desinfection chamber is rotatably connected to a drive
Moving axis 147 is provided with a hollow block 145 in the drive shaft 147, and the connection of about one end wall is provided in the hollow block 145
The cylindrical groove 127 of the desinfection chamber 101,147 upper end of drive shaft is through about 127 end wall of cylindrical groove and is located at described
In desinfection chamber 101,147 upper end of drive shaft is fixedly connected with a rear end face and is fixedly connected with 101 aft bulkhead of desinfection chamber
Driving motor 144, a left end wall is provided in the cylindrical groove 127 in 147 left side of drive shaft and is connected to the cylindrical groove
127 limiting slot 146 is provided with the elastic groove that a right end wall is connected to the cylindrical groove 127 in 127 left side of cylindrical groove
150, the 150 left end wall of elastic groove is fixedly connected with an elastomeric spring 149, and 149 right end of elastomeric spring is fixedly connected with
One right end is through the 150 right end wall of elastic groove and the 146 left end wall of limiting slot and the triangle in the limiting slot 146
Block 148,145 left side of hollow block are fixedly connected with a l-shaped rod 103, and 101 aft bulkhead of desinfection chamber is fixedly connected with one
Power supply box 104 is provided with the socket 102 that a right end wall is connected to the desinfection chamber 101 in 104 right side of power supply box, described
A temperature block 139 being fixedly connected with 101 aft bulkhead of desinfection chamber is provided on the right side of power supply box 104, in the temperature block 139
It is provided with a temperature slot 140, a stopper 143 is fixedly connected in the temperature slot 140, is arranged on the right side of the stopper 143
There is a movable block 142 being slidably connected with the temperature slot 140, one or so end difference is fixedly connected on the movable block 142
On the right side of 140 left hand end wall of temperature slot and the stock 138 in the desinfection chamber 101,138 upper surface of stock
It is fixedly connected with a rack gear block 137,138 left end of stock is fixedly connected with a supporting block 152,152 left end of supporting block
Face is fixedly connected with a plug 153, and the supporting block 152 is fixedly connected with the driving motor 144 by electric wire 151.
Valuably, the drainage mechanism 201 includes oscillating rod 134, is provided with a torque in 101 aft bulkhead of desinfection chamber
Slot 188,188 aft bulkhead of torsional channel are rotatably connected to a front end through 188 front bulkhead of torsional channel and are located at the nothing
Torque axis 135 in bacterium room 101 is provided with a torsion spring 189, the nothing between the torque axis 135 and the torsional channel 188
It is fixedly connected with a two-way gear 136 on 101 internal torque axis 135 of bacterium room, has been provided with one and institute on front side of the two-way gear 136
The oscillating rod 134 that torque axis 135 is fixedly connected is stated, 101 aft bulkhead of the desinfection chamber is fixedly connected with a storage block 125, described
It is provided with a seal groove 124 in storage block 125, is provided with an input slot 123, the sealing in 124 aft bulkhead of seal groove
It is provided with a sump pit 129 in 124 lower end wall of slot, a drain block 128, the drain are slidably connected in the sump pit 129
One or so end is fixedly connected on block 128 to extend through 129 left hand end wall of sump pit and be located in the desinfection chamber 101
Two-way bar 130, two-way 130 left end of bar are fixedly connected with an infusion block 119, and two-way 130 right end of bar is fixedly connected with
One drain block 131, the seal groove 124 are connected by medial launder 126 with the sump pit 129, are set in the medial launder 126
It is equipped with a check valve 122,126 left side of medial launder is fixedly connected with a perfusion tube 113, the 129 left end wall of sump pit
It is provided with the output magazine 121 of the connection perfusion tube 113 and the sump pit 129, it is single to be provided with one in the output magazine 121
To valve 122,101 aft bulkhead of desinfection chamber is fixedly connected with a positioning block 110,110 right side of the locating piece rotation connection
There is a locating shaft 111,111 right end of locating shaft is fixedly connected with a ratchet wheel block 112, is provided with one in the ratchet wheel block 112
Ratchet slot 182, a ratchet shaft 114 is provided on the right side of the locating shaft 111, and the ratchet slot is run through in 114 left end of ratchet shaft
182 right end walls and be located at the ratchet slot 182 in, 114 left end of ratchet shaft is fixedly connected with a ratchet 187, the ratchet
About 182 end wall of slot is symmetrically fixedly connected with a bottom biock 185, is provided with a lower end in 185 lower end surface of upside bottom biock
Wall is connected to the base channel 183 of the ratchet slot 182, and 183 upper end wall of base channel is fixedly connected with a bottom spring 184, institute
184 lower end of bottom spring is stated to be fixedly connected with a lower end through 183 lower end wall of base channel and contact biography with the ratchet 187
The elastic force block 186 of dynamic connection, 114 right end of ratchet shaft are fixedly connected with a drive bevel gear 115, after the locating piece 110
End wall is rotatably connected to a rotary shaft 118, and a left end and the drive bevel gear 115 are fixedly connected in the rotary shaft 118
The rotation bevel gear 117 that rear end is connected by meshing transmission is provided with one and the rotary shaft 118 on rear side of the rotation bevel gear 117
The release link 116 being fixedly connected.
Valuably, the swaying mechanism 202 includes heat conducting bar 141, and 101 aft bulkhead of desinfection chamber is fixedly connected with one
Fagging 105 is embedded with end in the support plate 105 and is located at the heat conducting bar 141 in the temperature slot 140, the desinfection chamber
101 aft bulkheads are fixedly connected with a placement block 133, and about one end wall is provided in the placement block 133 and is connected to the desinfection chamber
101 bilateral slot 132 is provided with the gravity-feed tank that a upper end wall is connected to the desinfection chamber 101 in placement 133 upper surface of block
171, the square groove 175 that a right end wall is connected to the gravity-feed tank 171 is provided in 171 leftmost side end wall of gravity-feed tank, it is described
A upper end is slidably connected in gravity-feed tank 171 through 171 upper end wall of gravity-feed tank and the annular in the desinfection chamber 101
Block 165,165 upper surface are placed with a culture bottle 106, and upper end wall connection is provided in 106 upper surface of culture bottle
A rear end face and the ratchet wheel block are fixedly connected on rear side of 165 upper surface of ring block described in the culture tank 109 of the desinfection chamber 101
112 extension bars 190 being connected by meshing transmission, 165 lower end surface of ring block and 171 upper end wall of gravity-feed tank pass through six weights
Power spring 172 is fixedly connected.The electromagnetism slot 166 that a right end wall is connected to the gravity-feed tank 171 is provided in the ring block 165,
The 166 left end wall of electromagnetism slot is fixedly connected with an electromagnetic spring 167, and 167 right end of electromagnetic spring is fixedly connected with a right side
End is through the 166 right end wall of electromagnetism slot and the electromagnetic block 168 in the gravity-feed tank 171;
Wherein, the stuck slot 170 that a left end wall is connected to the gravity-feed tank 171 is provided on the right side of the square groove 175, it is described stuck
170 right end wall of slot is fixedly connected with a magnet 169, and it is described rectangular that 175 lower end wall of square groove is provided with upper end wall connection
The shifting chute 176 of slot 175, the 176 left end wall of shifting chute are fixedly connected with a mobile spring 178, and the mobile spring 178 is right
End is fixedly connected with a movable block 177 being slidably connected with the shifting chute 176, and 177 upper surface of movable block is fixedly connected
There is a upper end through 176 upper end wall of shifting chute and the mobile bar 179 in the square groove 175, the mobile bar 179
Upper end is fixedly connected with a circular cone 180, and one is provided on the right side of the circular cone 180 and is rotated with 175 aft bulkhead of square groove
The jackshaft 173 of connection is fixedly connected with the engagement of 165 left end face of a right end budget statement ring block on the jackshaft 173 and passes
The intermediate gear 107 of connection is moved, a lower end wall is provided in 107 lower end surface of intermediate gear and is connected to the square groove 175
Swivelling chute 174 is provided with the drawstring axis 154 of one with 101 aft bulkhead of desinfection chamber rotation connection on the upside of the circular cone 180,
The drawstring gear that a lower end and 180 upper surface of circular cone are connected by meshing transmission is fixedly connected on the drawstring axis 154
181, the annular groove 161 that a upper end wall is connected to the desinfection chamber 101, the annular groove 161 are provided in 175 upper end wall of square groove
It is provided with a vertical slots 164 between the square groove 175, is provided with a movement slots 158, institute in the 164 left end wall of vertical slots
State and slidably connect a moving mass 157 in movement slots 158,157 lower end surface of moving mass be fixedly connected with a lower end with it is described
The movement spring 156 that 158 lower end wall of movement slots is fixedly connected, 157 right side of moving mass are fixedly connected with a right end and run through
The 158 right end wall of movement slots and the moving lever 159 being located in the vertical slots 164,159 right end of moving lever is fixedly connected
There is an elevator 163,163 lower end surface of elevator is fixedly connected with the drawstring axis 154 by fly rope 155, described
An arc block 160 being slidably connected with the vertical slots 164 is provided on the upside of elevator 163,160 upper surface of arc block is solid
Surely a upper end is connected with through the annular groove 161 and is located in the desinfection chamber 101 and is rocked bar 162, it is described to be located at desinfection chamber
162 left side of bar of rocking in 101 is fixedly connected with a swingle 108.
In the following, applicant will be a kind of thin using aquiculture animal with reference to attached drawing 1-4 and the application described above
It is a kind of thin using aquiculture animal to introduce the application in detail that bacteria vaccine device carries out the concrete composition of vaccine preparation method
The application method of bacteria vaccine device progress vaccine preparation method: firstly, in the initial state, the power supply box 104 is closed, described
Corner block 148 is located in the limiting slot 146, the electromagnetic spring 167, the movement spring 156 and the mobile spring 178
In compressive state, the mobile spring 178 is in normal condition, and the arc block 160 is located in the vertical slots 164, institute
It states in seal groove 124 and the sump pit 129 full of bacterium liquid;
In use, the power supply box 104 is opened, the agar training of the certain temperature after heating disinfection is added toward the culture tank 109
Nutrient solution, 106 mass of culture bottle increase, and decline to press the ring block 165, the ring block 165 drives the institute
The decline of extension bar 190 is stated, by the engaged transmission of the extension bar 190 and the ratchet wheel block 112, drives the ratchet wheel block 112
Rotation, the ratchet wheel block 112 drives the elastic force block 186 to rotate, under the rotation in this direction, the elastic force block 186 without
It moves the ratchet 187 to rotate, when agar culture solution is added to a certain degree, the electromagnetic block 168 moves to institute with ring block 165
Stuck 170 position of slot is stated, the electromagnetic spring 167 resets to the right, and the electromagnetic block 168 is driven to enter in the stuck slot 170
Stuck, the gravity spring 172 is compressed, and by the engaged transmission of the ring block 165 and the intermediate gear 107, is driven
The intermediate gear 107 rotates, until the swivelling chute 174 moves at the circular cone 180, the mobile spring 178 is to the right
It resets, the circular cone 180 is driven to enter in the swivelling chute 174, pass through the circular cone 180 and the drawstring gear 181
Engaged transmission, drive the drawstring gear 181 to rotate, so that the drawstring axis 154 be driven to rotate, the drawstring axis 154 is put
The pine fly rope 155, the movement spring 156 reset upwards, so that the elevator 163 is driven to reset upwards, thus
The arc block 160 is released into the vertical slots 164 upwards and is entered in the annular groove 161, the arc block 160 drives described
It rocks bar 162 and rises the jack-up left side culture bottle 106;
Meanwhile heat is conducted by the heat conducting bar 141 to the temperature slot 140 in the culture tank 109, so that the temperature
Gas expansion in slot 140 is spent, so that the movable block 142 be pushed to move downward, the movable block 142 drives the stock
138 move downward, and the stock 138 drives the plug 153 to move downward with the rack gear block 137,137 band of rack gear block
It moves the two-way gear 136 and rotates clockwise a distance, the plug 153, which enters to the left in the socket 102, to be powered, and passes through
The driving motor 144 is opened in the conduction of the electric wire 151, so that the drive shaft 147 be driven to rotate, passes through the triangle
The blocking of block 148 and the limiting slot 146, the drive shaft 147 drive the l-shaped rod 103 to rotate, and the l-shaped rod 103 drives
The swingle 108 rotates, to drive the arc block 160 to move in the annular groove 161, thus to the culture bottle
106, which carry out one, uniformly rocks, and one layer of uniform agar medium is formed in 109 lower end surface of culture tank, when the training
It supports in slot 109 after agar medium cooling, the movable block 142 moves right reset under gas pressure, so that the plug
153 are detached from the socket 102, stop rocking to the culture bottle 106, and the rack gear block 137, which moves right, drives described pair
It is rotated counterclockwise to gear 136, so that the torque axis 135 be driven to rotate, the torque axis 135 drives the oscillating rod 134
Rotation, the oscillating rod 134 pushes the drain block 131 to move downward, so that the two-way bar 130 is driven to move downward, institute
Stating two-way bar 130 drives the drain block 128 to move downward, to the bacterium liquid in the drain block 128 be passed through described defeated
Liquid pipe 113 is discharged into the culture tank 109, and when that need to carry out the production of next vaccine culture bottle, the culture bottle 106 is taken away
Sealing, the magnet 169, which is powered, generates repulsion to the electromagnetic block 168, so that it is described stuck to push the electromagnetic block 168 to be detached from
The blocking of slot 170, the gravity spring 172 resets upwards drives the ring block 165 to rise, to drive the extension bar
190 move upwards, and by the engaged transmission of the extension bar 190 and the ratchet wheel block 112, the ratchet wheel block 112 are driven to rotate,
The ratchet wheel block 112 drives the elastic force block 186 to rotate, and in this rotation direction, the elastic force block 186 can drive the spine
187 rotation of wheel, the ratchet 187 drive the ratchet shaft 114 to rotate, and the ratchet shaft 114 drives the drive bevel gear 115
Rotation can drive the rotary shaft 118 by the engaged transmission of the drive bevel gear 115 and the rotation bevel gear 117
The infusion block 119 is pushed to the right a distance, the sump pit 129 so that the release link 116 be driven to rotate by rotation
A certain amount of bacterium liquid is inside refilled, the new culture bottle 106 is put into.
The beneficial effects of the present invention are: present apparatus structure is simple, bacterium cultivates bottle in the carry out production of vaccine that can be automated
Manufacturing process, plant automation degree is higher, and people is also reduced while saving labour in the place that seldom manpower participates in
Body carries the possibility that bacterium is mixed into culture bottle, it is ensured that the quality of vaccine, and this device is after making a vaccine culture bottle
Next production can be carried out, it is suitable for mass production, Production Time is saved, whole device has only used a power source, whole
Transmission efficiency is higher, and energy utilization rate is higher.
The above, the specific embodiment only invented, but invent protection scope be not limited thereto, it is any without
The change or replacement that creative work is expected are crossed, should all be covered within the protection scope of invention.Therefore, the protection scope of invention
It should be determined by the scope of protection defined in the claims.
Claims (5)
1. a kind of carry out vaccine preparation method using aquiculture animal bacterial vaccine device, wherein the aquiculture animal is thin
Bacteria vaccine device includes incubator, and a desinfection chamber is provided in the incubator, a driving mechanism is provided in the desinfection chamber,
The driving mechanism includes l-shaped rod, limiting slot, corner block and power supply box, and the power supply box is as power source drive whole device
Work drives the l-shaped rod to rotate by the limiting slot and the stuck of the corner block, and the driving mechanism further includes temperature
Slot and movable block to be spent, is provided with a swaying mechanism on the upside of the driving mechanism, the swaying mechanism includes culture bottle and heat conducting bar,
The heat conducting bar can conduct the heat of the culture bottle to the temperature slot, so that the movable block is driven to move downward,
The swaying mechanism further includes arc block, vertical slots and annular groove, can stop institute when the arc block is located in the vertical slots
The rotation of l-shaped rod is stated, so that the corner block is detached from the blocking of the limiting slot, when the arc block is located in annular groove
When, the l-shaped rod can drive the arc block to rotate in the annular groove, and the swaying mechanism further includes ring block, when described
After ring block declines a distance, the arc block just be can enter in the annular groove, and the driving mechanism further includes rack gear block, institute
It states and is provided with a drainage mechanism on the right side of swaying mechanism, the drainage mechanism includes two-way gear, ratchet wheel block, drain block and drain
Slot only can push the drain block to move downward when the rack gear block moves, and bacterium liquid in the sump pit is discharged into described
In culture bottle, only when the ring block rises, the release link can push the drain block to move right, and carry out next bacterium
The filling of liquid, the drainage mechanism further include two check valves, flow direction of the check valve to control bacterium liquid;
Being technically characterized in that when the culture bottle reaches certain temperature for this method, may make the driving mechanism energization work
Make, when the culture bottle reaches certain mass, the arc block can be detached from the stuck of the vertical slots and enter the annular groove,
By the barrier effect of the corner block and the limiting slot, the arc block can be driven to move in the annular groove, thus right
Culture bottle is uniformly rocked, and when the culture bottle temperature reduces, the rack gear block can drive the drain block to transport to the left
It is dynamic, Quantifying Bacteria liquid is added into the culture bottle.
2. it is according to claim 1 it is a kind of using aquiculture animal bacterial vaccine device carry out vaccine preparation method,
In, the driving mechanism includes corner block, and the desinfection chamber lower end wall is rotatably connected to a drive shaft, is arranged in the drive shaft
There is a hollow block, the cylindrical groove that about one end wall is connected to the desinfection chamber, drive shaft upper end are provided in the hollow block
Through end wall above and below the cylindrical groove and it is located in the desinfection chamber, the drive shaft upper end is fixedly connected with a rear end face and institute
The driving motor that desinfection chamber aft bulkhead is fixedly connected is stated, left end wall company is provided in the cylindrical groove in drive shaft left side
Lead to the limiting slot of the cylindrical groove, the elastic groove that a right end wall is connected to the cylindrical groove be provided in the cylindrical groove left side,
Elastic groove left end wall is fixedly connected with an elastomeric spring, and the elastomeric spring right end is fixedly connected with a right end through described
Elastic groove right end wall and limiting slot left end wall and the corner block being located in the limiting slot, the hollow block left side is fixed
It is connected with a l-shaped rod, the desinfection chamber aft bulkhead is fixedly connected with a power supply box, and a right side is provided in the power supply box right side
End wall is connected to the socket of the desinfection chamber, is provided with a temperature being fixedly connected with the desinfection chamber aft bulkhead on the right side of the power supply box
Block is spent, is provided with a temperature slot in the temperature block, a stopper, the stopper right side are fixedly connected in the temperature slot
It is provided with a movable block being slidably connected with the temperature slot, one or so end is fixedly connected on the movable block and extends through institute
It states temperature slot left hand end wall and is located at the sterile indoor stock, be fixedly connected with a rack gear on the right side of the stock upper surface
Block, the stock left end are fixedly connected with a supporting block, and the supporting block left side is fixedly connected with a plug, the supporting block
It is fixedly connected with the driving motor by electric wire;
It is characterized by: gas expansion in the temperature slot, so that the movable block is pushed to move downward, the movable block
The stock is driven to move downward, the stock drives the plug to move downward with the rack gear block, and the rack gear block drives
The two-way gear rotates clockwise a distance, to open the driving motor, to drive the drive shaft turns, leads to
The blocking of the corner block Yu the limiting slot is crossed, the drive shaft drives the l-shaped rod rotation.
3. it is according to claim 1 it is a kind of using aquiculture animal bacterial vaccine device carry out vaccine preparation method,
In, the drainage mechanism includes oscillating rod, and a torsional channel is provided in the desinfection chamber aft bulkhead, and the torsional channel aft bulkhead turns
It is dynamic to be connected with a front end through the torsional channel front bulkhead and be located at the sterile indoor torque axis, the torque axis with it is described
It is provided with a torsion spring between torsional channel, a two-way gear, the bi-directional teeth are fixedly connected on the desinfection chamber internal torque axis
Wheel front side is provided with an oscillating rod being fixedly connected with the torque axis, and the desinfection chamber aft bulkhead is fixedly connected with a storage
Block is provided with a seal groove in the storage block, an input slot, the seal groove lower end is provided in the seal groove aft bulkhead
It is provided with a sump pit in wall, a drain block is slidably connected in the sump pit, a left side is fixedly connected on the drain block
Right end extends through the sump pit left hand end wall and is located at the sterile indoor two-way bar, and the two-way bar left end is fixed to be connected
It is connected to an infusion block, the two-way bar right end is fixedly connected with a drain block, and the seal groove and the sump pit pass through centre
Slot is connected, and a check valve is provided in the medial launder, and the medial launder left side is fixedly connected with a perfusion tube, the row
Liquid bath left end wall is provided with the output magazine of the connection perfusion tube and the sump pit, and it is unidirectional that one is provided in the output magazine
Valve, the desinfection chamber aft bulkhead are fixedly connected with a positioning block, and the locating piece right side is rotatably connected to a locating shaft, described
Locating shaft right end is fixedly connected with a ratchet wheel block, and a ratchet slot is provided in the ratchet wheel block, is provided on the right side of the locating shaft
One ratchet shaft, the ratchet shaft left end is through the ratchet slot right end wall and is located in the ratchet slot, the ratchet shaft left end
It is fixedly connected with a ratchet, end wall is symmetrically fixedly connected with a bottom biock, upside bottom biock lower end to the ratchet slot up and down
The base channel that a lower end wall is connected to the ratchet slot is provided in face, the base channel upper end wall is fixedly connected with a bottom bullet
Spring, the bottom lower spring end are fixedly connected with a lower end through the base channel lower end wall and connect with the ratchet Contact Transmission
The elastic force block connect, the ratchet shaft right end are fixedly connected with a drive bevel gear, and the locating piece aft bulkhead is rotatably connected to one
Rotary shaft is fixedly connected with the rotating cone tooth that a left end and the drive bevel gear rear end are connected by meshing transmission in the rotary shaft
Wheel, the rotation bevel gear rear side are provided with a release link being fixedly connected with the rotary shaft;
It is characterized by: the two-way gear rotates counterclockwise, so that the torque axis be driven to rotate, the torque axis drives institute
Oscillating rod rotation is stated, the oscillating rod pushes the drain block to move downward, so that the two-way bar is driven to move downward, it is described
Two-way bar drives the drain block to move downward, so that the bacterium liquid in the drain block is discharged by the perfusion tube.
4. it is according to claim 1 it is a kind of using aquiculture animal bacterial vaccine device carry out vaccine preparation method,
In, the swaying mechanism includes heat conducting bar, and the desinfection chamber aft bulkhead is fixedly connected with a support plate, is embedded in the support plate
There is a lower end to be located at the heat conducting bar in the temperature slot, the desinfection chamber aft bulkhead is fixedly connected with a placement block, the placement
It is provided with the bilateral slot that about one end wall is connected to the desinfection chamber in block, upper end wall company is provided in placement block upper surface
Lead to the gravity-feed tank of the desinfection chamber, a right end wall is provided in the end wall of the gravity-feed tank leftmost side and is connected to the rectangular of the gravity-feed tank
Slot slidably connects a upper end in the gravity-feed tank through the gravity-feed tank upper end wall and is located at the sterile indoor annular
Block, the upper surface are placed with a culture bottle, are provided with a upper end wall in the culture bottle upper surface and are connected to the desinfection chamber
The extension bar that a rear end face and the ratchet wheel block are connected by meshing transmission is fixedly connected on rear side of ring block upper surface described in culture tank,
The ring block lower end surface is fixedly connected with the gravity-feed tank upper end wall by six gravity springs.
5. being provided with the electromagnetism slot that a right end wall is connected to the gravity-feed tank in the ring block, electromagnetism slot left end wall is fixed to be connected
It is connected to an electromagnetic spring, the electromagnetic spring right end is fixedly connected with a right end through the electromagnetism slot right end wall and is located at described
Electromagnetic block in gravity-feed tank;
Wherein, the stuck slot that a left end wall is connected to the gravity-feed tank, the stuck slot right end wall are provided on the right side of the square groove
It is fixedly connected with a magnet, the square groove lower end wall is provided with the shifting chute that a upper end wall is connected to the square groove, the shifting
Dynamic slot left end wall is fixedly connected with a mobile spring, and the mobile spring right end is fixedly connected with one and connects with shifting chute sliding
The movable block connect, the movable block upper surface are fixedly connected with a upper end through the shifting chute upper end wall and are located at described rectangular
Mobile bar in slot, the mobile bar upper end are fixedly connected with a circular cone, are provided with one and the side on the right side of the circular cone
The jackshaft of shape slot aft bulkhead rotation connection, is fixedly connected with a right end budget statement ring block left end face on the jackshaft and nibbles
The intermediate gear of transmission connection is closed, is provided with the rotation that a lower end wall is connected to the square groove in the intermediate gear lower end surface
Slot, the circular cone upside are provided with the drawstring axis of one with desinfection chamber aft bulkhead rotation connection, fix on the drawstring axis
It is connected with the drawstring gear that a lower end and the circular cone upper surface are connected by meshing transmission, is provided in the square groove upper end wall
One upper end wall is connected to the annular groove of the desinfection chamber, and a vertical slots, the vertical slots are provided between the annular groove and the square groove
It is provided with a movement slots in the wall of left end, a moving mass is slidably connected in the movement slots, the moving mass lower end surface is fixed to be connected
It is connected to the movement spring that a lower end is fixedly connected with the movement slots lower end wall, the moving mass right side is fixedly connected with a right side
End is through the movement slots right end wall and the moving lever in the vertical slots, the moving lever right end are fixedly connected with one liter
Block drops, and the elevator lower end surface is fixedly connected with the drawstring axis by fly rope, is provided with one on the upside of the elevator
The arc block being slidably connected with the vertical slots, the arc block upper surface are fixedly connected with a upper end through the annular groove and position
In it is described it is sterile it is indoor rock bar, it is described to be located at sterile indoor bar left side of rocking and be fixedly connected with a swingle;
It is characterized by: the power supply box is opened, the agar culture of the certain temperature after heating disinfection is added toward the culture tank
Liquid, the culture bottle quality increase, to press the ring block decline, the ring block is driven under the extension bar
Drop drives the ratchet wheel block to rotate by the engaged transmission of the extension bar and the ratchet wheel block, described in the ratchet wheel block drive
The rotation of elastic force block, under the rotation in this direction, the elastic force block does not drive the ratchet wheel, when agar culture solution is added to one
When determining degree, the electromagnetic block moves to the stuck groove location with ring block, and the electromagnetic spring resets to the right, described in drive
Electromagnetic block enters stuck in the stuck slot, and the gravity spring is compressed, and the ring block and the intermediate gear are passed through
Engaged transmission drives the intermediate gear to rotate, until the swivelling chute moves at the circular cone, the mobile spring is to the right
It resets, the circular cone is driven to enter in the swivelling chute, pass through the engaged transmission of the circular cone and the drawstring gear, band
The drawstring gear rotation is moved, so that the drawstring axis be driven to rotate, the drawstring axis loosens the fly rope, the movement
Spring resets upwards, to drive the elevator to reset upwards, so that the arc block is released the vertical slots simultaneously upwards
Into in the annular groove, bar is rocked described in the arc block drive and rises the jack-up left side culture bottle.
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CN201910272834.0A CN109971631A (en) | 2019-04-04 | 2019-04-04 | It is a kind of to carry out vaccine preparation method using aquiculture animal bacterial vaccine device |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111772854A (en) * | 2020-07-01 | 2020-10-16 | 江汉大学 | Auxiliary device for animal experiments |
CN113292026A (en) * | 2021-07-22 | 2021-08-24 | 南通朗迪机械科技有限公司 | Plastic cover clamping linkage clamping cap screwing machine |
-
2019
- 2019-04-04 CN CN201910272834.0A patent/CN109971631A/en not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111772854A (en) * | 2020-07-01 | 2020-10-16 | 江汉大学 | Auxiliary device for animal experiments |
CN113292026A (en) * | 2021-07-22 | 2021-08-24 | 南通朗迪机械科技有限公司 | Plastic cover clamping linkage clamping cap screwing machine |
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Application publication date: 20190705 |