CN109966535B - Biological safety type high-pressure sterilizer and sterilization method - Google Patents
Biological safety type high-pressure sterilizer and sterilization method Download PDFInfo
- Publication number
- CN109966535B CN109966535B CN201910325059.0A CN201910325059A CN109966535B CN 109966535 B CN109966535 B CN 109966535B CN 201910325059 A CN201910325059 A CN 201910325059A CN 109966535 B CN109966535 B CN 109966535B
- Authority
- CN
- China
- Prior art keywords
- diaphragm valve
- pneumatic diaphragm
- air
- cavity
- stainless steel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L11/00—Methods specially adapted for refuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/12—Apparatus for isolating biocidal substances from the environment
- A61L2202/121—Sealings, e.g. doors, covers, valves, sluices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/85—Food storage or conservation, e.g. cooling or drying
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The invention discloses a biological safety type high-pressure sterilizer, which comprises a stainless steel cylindrical cavity, wherein two ends of the stainless steel cylindrical cavity are open ends, door plates are arranged at the two open ends of the stainless steel cylindrical cavity in a sealing and pressing mode, an outer ring mounting groove and an inner ring mounting groove are formed in the annular end face of the open end of the stainless steel cylindrical cavity, an outer ring sealing ring is arranged in the outer ring mounting groove, an inner ring sealing ring is arranged in the inner ring mounting groove, an air charging groove is formed between the outer ring mounting groove and the inner ring mounting groove in the annular end face of the open end of the stainless steel cylindrical cavity, and the door plates are in sealing fit with the outer ring sealing ring and the inner ring sealing ring.
Description
Technical Field
The invention belongs to the technical field of sterilization experimental devices, and particularly relates to a biological safety type high-pressure sterilizer, and a biological safety type high-pressure sterilization method which is suitable for sterilizing garbage generated by an infectious disease experiment.
Background
And sterilizing the garbage in the closed cavity by utilizing the damp and hot steam. 1. In the prior art, a cavity tail gas valve is closed, steam is injected into the cavity, the temperature is raised in a stuffy way, and the tail gas valve is opened for exhausting after sterilization is finished. Defects: the steam is introduced in a smoldering manner, so that a lot of condensed water is generated in the cavity in the 2 stages of heating and maintaining sterilization due to longer heating time, and accumulated in the cavity to influence the sterilization effect, and meanwhile, the drying effect on the sterilized articles is limited. This patent is adopted the tail gas valve and is opened always, then pours into steam through the control and realize rising temperature and sterilization to the cavity, and the advantage can realize the accurate control of temperature, and the evacuation drying effect is very good after guaranteeing to sterilize. The sterilized articles are dry and convenient to process.
2. The prior art is that when injecting steam into the cavity, the steam is a separate pipeline, and the defect is that: the pressure of the steam may thus be higher than the jacket pressure, resulting in large fluctuations in temperature control. After the advanced jacket preheating of steam reaches a certain temperature, the steam of the jacket is connected into the cavity through a control valve, so that the design can ensure that the actual input steam pressure in the cavity is always lower than the steam pressure of the jacket, the design is a safety protection design, and in addition, the temperature control fluctuation of the cavity is very small, so that the control is convenient.
3. In the prior art, a safety valve is arranged on a jacket and a cavity, and 2 safety valves are arranged, so that the defects are overcome: the inner cavity is provided with a pipeline opening, so that the biosafety risk is increased, and the manufacturing cost is increased. This patent has solved, only needs the installation to press from both sides the cover relief valve, can realize the safety guarantee, reduces biological safety risk.
4. In the prior art, a temperature sensor in a cavity is fixed on the cavity, and a sensor which is independently inserted into an object for detection is not provided, so that the defect is that: the real sterilization temperature of the article in the sterilization process is not accurate enough, and the sensor is bad or insensitive and can not be found in time without reference. This patent is fixed with 2 sensors in the cavity, forms the contrast, and still there is a special sensor of inserting the article the inside in addition, and 4 temperatures can both show, can realize the accurate control of temperature in the sterilization process to and the sensor trouble discovers immediately, has guaranteed biosafety.
5. In the prior art, after the cavity is pressed by the door plate, sterilization is started, and the ageing leakage risk of the door plate sealing ring exists. This patent has solved, and cavity door compresses tightly and closes the back, and timely sealing washer takes place to reveal, also can guarantee thoroughly to kill, guarantees biosafety.
6. The prior art comprises the following steps: most control systems are single-chip computers, programs are inconvenient to upgrade, and detection means are limited. This patent has solved, adopts PLC control, possesses computer access refreshing program function, and the design has the point detection function of PLC to each signal simultaneously, and the convenience is maintained and is overhauld.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provide a biological safety type autoclave and also provide a biological safety type autoclave method,
the invention is realized by the following technical scheme:
the utility model provides a biological safety type autoclave, including stainless steel tube-shape cavity, stainless steel tube-shape cavity both ends are the open end, two open ends of stainless steel tube-shape cavity are all sealed to be pressed and are equipped with the door plant, outer loop mounting groove and inner ring mounting groove have been seted up on the annular terminal surface of the open end of stainless steel tube-shape cavity, be provided with outer loop sealing washer in the outer loop mounting groove, be provided with inner ring sealing washer in the inner ring mounting groove, be located and have seted up the gas cell between outer loop mounting groove and the inner ring mounting groove on the annular terminal surface of the open end of stainless steel tube-shape cavity, the door plant is sealed laminating with outer loop sealing washer and inner ring sealing washer.
The inflation groove is provided with an inflation port and a deflation port, the inflation port is connected with a compressed air source through a second pneumatic diaphragm valve, the inflation port is also connected with an air outlet of the steam generator through a first pneumatic diaphragm valve, the deflation port is connected with a hot air inlet of the water-cooled heat exchanger through a ninth pneumatic diaphragm valve, and a hot air outlet of the water-cooled heat exchanger is connected with the water-sealed vacuum pump.
The bottom of the stainless steel cylindrical cavity is provided with a cavity steam inlet, the top of the stainless steel cylindrical cavity is provided with a cavity air outlet, the stainless steel cylindrical cavity is sleeved with a jacket, an air outlet of the steam generator is connected with one end of a third pneumatic diaphragm valve, the other end of the third pneumatic diaphragm valve is respectively connected with an air inlet of the jacket, the air inlet of the jacket is provided with a jacket temperature sensor and a first safety valve, an air outlet of the jacket is connected with the cavity steam inlet through a one-way valve and an eighth pneumatic diaphragm valve in sequence, the air outlet of the jacket is provided with a second drain valve,
the cavity exhaust port is connected with one end of a fourth pneumatic diaphragm valve, the other end of the fourth pneumatic diaphragm valve is provided with an exhaust temperature sensor and is connected with one end of a first air filter, the other end of the first air filter is connected with one end of a second air filter, the other end of the second air filter is respectively connected with one end of a fifth pneumatic diaphragm valve and one end of a sixth pneumatic diaphragm valve, the other end of the fifth pneumatic diaphragm valve is connected with an air outlet of a steam generator, and the other end of the sixth pneumatic diaphragm valve is connected with a hot air inlet of a water-cooled heat exchanger through an active carbon filter.
The second safety valve is arranged at the air outlet of the steam generator, and the first drain valve is also arranged at the air outlet of the steam generator.
The biological safety type high pressure sterilizer further comprises an intra-cavity pressure sensor for measuring the pressure in the stainless steel cylindrical cavity, an intra-cavity temperature sensor for measuring the temperature in the stainless steel cylindrical cavity, and a needle type temperature sensor for measuring the temperature of an article to be sterilized in the stainless steel cylindrical cavity.
The stainless steel cylinder cavity is also provided with an external air inlet hole, the external air inlet hole is connected with one end of a third air filter, and the other end of the third air filter is provided with a seventh pneumatic diaphragm valve.
A method of bio-safe autoclaving comprising the steps of:
the method comprises the following steps that 1, a first pneumatic diaphragm valve, a second pneumatic diaphragm valve, a third pneumatic diaphragm valve, a fourth pneumatic diaphragm valve, a fifth pneumatic diaphragm valve, a sixth pneumatic diaphragm valve, an eighth pneumatic diaphragm valve and a ninth pneumatic diaphragm valve are arranged in a closed state, and a seventh pneumatic diaphragm valve is in an open state;
step 4, opening the first pneumatic diaphragm valve and the ninth pneumatic diaphragm valve, and closing the ninth pneumatic diaphragm valve after waiting for 5 minutes;
step 5, opening a fourth pneumatic diaphragm valve and a sixth pneumatic diaphragm valve, starting a water-sealed vacuum pump to vacuumize, and stopping vacuumizing when the vacuum degree of the cavity of the stainless steel cylindrical cavity is lower than 0.1 bar;
step 6, opening a third pneumatic diaphragm valve, and heating the jacket temperature sensor to 123 ℃ required by sterilization and heating;
step 7, opening an eighth pneumatic diaphragm valve, closing a seventh pneumatic diaphragm valve, and enabling steam in the jacket to enter a cavity of the stainless steel cylinder-shaped cavity through the one-way valve, wherein a temperature sensor in the cavity is heated to 115 ℃;
and 13, closing the second pneumatic diaphragm valve, the fourth pneumatic diaphragm valve, the sixth pneumatic diaphragm valve and the ninth pneumatic diaphragm valve, and opening the first door plate or the second door plate.
Compared with the prior art, the invention has the following advantages:
1. for the system control mode:
in the traditional sterilizer, the single-chip microcomputer is adopted for control, so that the traditional sterilizer is inconvenient to upgrade. Valve control is also inconvenient to test;
according to the invention, PLC control is adopted, a sterilization program can be dynamically updated, and the equipment control and debugging stage is more flexible and convenient to maintain;
2. sealing the door plate and the cavity:
in the traditional sterilizer, a mechanical pressing gasket is adopted for sealing, and once the gasket is cracked in the sterilization process, toxic aerosol in a cavity can leak out to cause biological safety accidents;
according to the invention, after mechanical compression sealing, a steam protection barrier is formed around the periphery between the outer ring sealing ring and the inner ring sealing ring, once leakage occurs, the steam barrier can instantaneously kill leaked pathogenic microorganisms, and biological safety in the sterilization process is greatly improved;
3. aiming at exhaust emission:
in the traditional sterilizer, after the gas in the cavity is sealed, the temperature is raised and sterilized, the tail gas discharge valve is opened. The tail gas has peculiar smell;
in the sterilization process, the fourth pneumatic diaphragm valve (tail gas pipeline valve) is always opened, and tail gas is discharged after 3-level filtration. The tail gas is discharged after deodorizing;
4. aiming at the condition of generating condensed water in the cavity:
the traditional sterilizer is heated by steam under the closed condition, so that excessive condensed water is generated by the steam in the cavity, and even if the vacuum pumping is performed after the sterilization is finished, part of condensed water is remained, and the sterilized articles are inconvenient to take out;
according to the invention, after the jacket is preheated, jacket steam is input into the stainless steel cylinder-shaped cavity, so that condensed water is not generated in the stainless steel cylinder-shaped cavity in the heating process;
5. for steam entry mode:
a traditional sterilizer is put down, a tail gas pipeline control valve is closed, and the temperature is raised in a stuffy way;
according to the invention, the fourth pneumatic diaphragm valve (tail gas pipeline valve) is opened all the time and continuously heats up;
6. for the temperature sensor setting:
in the traditional sterilizer, a cavity is monitored by a single temperature sensor;
according to the invention, the stainless steel cylindrical cavity adopts the double temperature sensors, and the temperature is real by real-time comparison.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic view of a conventional door panel connection structure;
fig. 3 is a schematic view of the connection structure of the door panel of the present invention.
In the figure: 1-first pneumatic diaphragm valve, 2-second pneumatic diaphragm valve, 3-third pneumatic diaphragm valve, 4-fourth pneumatic diaphragm valve, 5-exhaust temperature sensor, 6-first air filter, 7-fifth pneumatic diaphragm valve, 8-second air filter, 9-sixth pneumatic diaphragm valve, 10-activated carbon filter, 11-first door panel, 12-first outer ring seal ring, 13-first inner ring seal ring, 14-intra-cavity pressure sensor, 15-first intra-cavity temperature sensor, 16-jacket temperature sensor, 17-first safety valve, 18-needle type temperature sensor, 19-second intra-cavity temperature sensor, 20-third air filter, 21-seventh pneumatic diaphragm valve, 22-cavity exhaust port, 23-second outer ring seal ring, 24-second inner ring seal ring, 25-second door panel, 26-jacket, 27-cavity vapor inlet, 28-stainless steel cylindrical cavity, 29-second safety valve, 30-steam generator, 31-first drain valve, 32-second drain valve, 33-eighth pneumatic valve, 33-eighth air-drain valve, air-third air filter, water-seal type air valve, 37-eighth pneumatic diaphragm valve, water-cooled air pump, air-third air filter, air-vent valve, air-seal type air-third air-vent valve, air-eighth pneumatic diaphragm valve, air-eighth-vent, air-pump, air-eighth air-vent, air-pump air-eighth air-vent, air-valve, air-pump air-vent, etc.; 38-existing cavity; 39-existing washers; 40-existing door panels; 41-an outer ring mounting groove; 42-an inner ring mounting groove; 43-an outer ring seal ring; 44-an inner ring seal ring; 45-an inflatable tank.
Detailed Description
The present invention will be further described in detail below in conjunction with the following examples, for the purpose of facilitating understanding and practicing the present invention by those of ordinary skill in the art, it being understood that the examples described herein are for the purpose of illustration and explanation only and are not intended to limit the invention.
The utility model provides a biological safety type autoclave, including stainless steel tube-shape cavity 28, stainless steel tube-shape cavity 28 both ends are the open end, two open ends of stainless steel tube-shape cavity 28 all seal and press and are equipped with the door plant, outer loop mounting groove 41 and inner loop mounting groove 42 have been seted up on the annular terminal surface 46 of the open end of stainless steel tube-shape cavity 28, be provided with outer loop sealing washer 43 in the outer loop mounting groove 41, be provided with inner loop sealing washer 44 in the inner loop mounting groove 42, the inflation groove 45 has been seted up between outer loop mounting groove 41 and inner loop mounting groove 42 on the annular terminal surface 46 of the open end of stainless steel tube-shape cavity 28, the door plant is sealed laminating with outer loop sealing washer 43 and inner loop sealing washer 44.
The air charging groove 45 is provided with an air charging port and an air discharging port, the air charging port is connected with a compressed air source through the second pneumatic diaphragm valve 2, the air charging port is also connected with an air outlet of the steam generator 30 through the first pneumatic diaphragm valve 1, the air discharging port is connected with a hot air inlet of the water-cooled heat exchanger 36 through the ninth pneumatic diaphragm valve 35, and a hot air outlet of the water-cooled heat exchanger 36 is connected with the water-sealed vacuum pump 37.
The bottom of the stainless steel cylinder cavity 28 is provided with a cavity steam inlet 27, the top of the stainless steel cylinder cavity 28 is provided with a cavity air outlet 22, the stainless steel cylinder cavity 28 is sleeved with a jacket 26, an air outlet of a steam generator 30 is connected with one end of a third pneumatic diaphragm valve 3, the other end of the third pneumatic diaphragm valve 3 is respectively connected with an air inlet of the jacket 26, an air inlet of the jacket 26 is provided with a jacket temperature sensor 16 and a first safety valve 17, an air outlet of the jacket 26 is connected with the cavity steam inlet 27 through a one-way valve 33 and an eighth pneumatic diaphragm valve 34 in sequence, an air outlet of the jacket 26 is provided with a second drain valve 32,
the cavity exhaust port 22 is connected with one end of the fourth pneumatic diaphragm valve 4, the other end of the fourth pneumatic diaphragm valve 4 is provided with an exhaust temperature sensor 5 and is connected with one end of the first air filter 6, the other end of the first air filter 6 is connected with one end of the second air filter 8, the other end of the second air filter 8 is respectively connected with one end of the fifth pneumatic diaphragm valve 7 and one end of the sixth pneumatic diaphragm valve 9, the other end of the fifth pneumatic diaphragm valve 7 is connected with an air outlet of the steam generator 30, and the other end of the sixth pneumatic diaphragm valve 9 is connected with a hot air inlet of the water-cooled heat exchanger 36 through the activated carbon filter 10.
The second safety valve 29 is arranged at the air outlet of the steam generator 30, and the first drain valve 31 is also arranged at the air outlet of the steam generator 30.
The bio-safe autoclave further includes an intra-cavity pressure sensor 14 for measuring the pressure in the stainless steel cylindrical cavity 28, and intra-cavity temperature sensors (a first intra-cavity temperature sensor 15 and a second intra-cavity temperature sensor 19) for measuring the temperature of the stainless steel cylindrical cavity 28, and a needle temperature sensor 18 for measuring the temperature of the articles to be sterilized in the stainless steel cylindrical cavity 28.
The stainless steel cylindrical cavity 28 is also provided with an external air inlet hole, the external air inlet hole is connected with one end of the third air filter 20, and the other end of the third air filter 20 is provided with a seventh pneumatic diaphragm valve 21.
In the present application, the first air-operated diaphragm valve 1, the second air-operated diaphragm valve 2, the third air-operated diaphragm valve 3, the fourth air-operated diaphragm valve 4, the exhaust temperature sensor 5, the first air filter 6, the fifth air-operated diaphragm valve 7, the sixth air-operated diaphragm valve 9, the intra-cavity pressure sensor 14, the first intra-cavity temperature sensor 15, the jacket temperature sensor 16, the first safety valve 17, the needle temperature sensor 18, the second intra-cavity temperature sensor 19, the seventh air-operated diaphragm valve 21, the second safety valve 29, the steam generator 30, the first drain valve 31, the second drain valve 32, the check valve 33, the eighth air-operated diaphragm valve 34, the ninth air-operated diaphragm valve 35, and the water-seal type vacuum pump 37 are all connected to the PLC control module, and have individual programming functions. The vacuum rate of the vacuum in the sterilization process and the times of the vacuum can be set, and the temperature and the duration of the sterilization maintenance stage of the sterilizer can be set.
The two open ends of the stainless steel cylindrical cavity 28 are respectively provided with a door plate (11, 25) in a sealing way, the part of the outer ring sealing ring, which is exposed out of the outer ring mounting groove, and the part of the inner ring sealing ring, which is exposed out of the inner ring mounting groove, are tightly pressed and sealed by the door plate, the inflatable groove between the outer ring mounting groove and the inner ring mounting groove is filled with steam, the part of the outer ring sealing ring, which is exposed out of the outer ring mounting groove, and the part of the inner ring sealing ring, which is exposed out of the inner ring mounting groove, are also filled with steam to form a steam barrier, the stainless steel cylindrical cavity 28 is vacuumized, then the jacket 26 is introduced with steam, the jacket 26 is preheated to reach a temperature favorable for sterilization, and the steam of the jacket 26 is utilized to enter the stainless steel cylindrical cavity 28 to realize the temperature rising sterilization in the stainless steel cylindrical cavity 28. And (5) timing when the temperature in the cavity reaches the temperature required by sterilization, and after timing, vacuumizing and drying the cavity, wherein the drying is finished.
A method of bio-safe autoclaving comprising the steps of:
in the step 1, the first pneumatic diaphragm valve 1, the second pneumatic diaphragm valve 2, the third pneumatic diaphragm valve 3, the fourth pneumatic diaphragm valve 4, the fifth pneumatic diaphragm valve 7, the sixth pneumatic diaphragm valve 9, the eighth pneumatic diaphragm valve 34 and the ninth pneumatic diaphragm valve 35 are all in a closed state. The seventh air-operated diaphragm valve 21 is in an open state.
step 4, opening the first pneumatic diaphragm valve 1, closing the ninth pneumatic diaphragm valve 35 after waiting for 5 minutes (in order to form a steam barrier by the door plate sealing ring);
step 5, opening the fourth pneumatic diaphragm valve 4 and the sixth pneumatic diaphragm valve 9, starting a water-sealed vacuum pump 37 to vacuumize until the vacuum degree of the stainless steel cylindrical cavity 28 is less than 0.1bar (0.01 Mpa), and stopping vacuumizing (the purpose of vacuumizing is to reduce uneven temperature rise in the cavity and reduce the influence of air on the sterilization process);
step 6, opening a third pneumatic diaphragm valve 3, and heating the jacket temperature sensor 16 to 123 ℃ required by sterilization and heating; due to the design of the second drain valve 32, 3.5bar steam generated by the steam generator is allowed to pass into the jacket 26.
Step 7, opening an eighth pneumatic diaphragm valve 34, closing a seventh pneumatic diaphragm valve 21, and enabling steam in the jacket 26 to enter the cavity of the stainless steel cylinder-shaped cavity 28 through the one-way valve 33, wherein the temperature sensor (15, 19) in the cavity is heated to be close to 115 ℃;
If it is necessary to interrupt the sterilization process during the steps 3 to 9, the steps 10 to 12 are performed, and the second air-operated diaphragm valve 2, the fourth air-operated diaphragm valve 4, the sixth air-operated diaphragm valve 9, and the ninth air-operated diaphragm valve 35 are all closed. The door panel (the first door panel 11 or the second door panel 25) when the article to be sterilized is put in the embodiment of step 3 is opened.
The whole procedure of sterilization is ended. The valve states of the sterilizer return to the first step state, and the first air-operated diaphragm valve 1, the second air-operated diaphragm valve 2, the third air-operated diaphragm valve 3, the fourth air-operated diaphragm valve 4, the fifth air-operated diaphragm valve 7, the sixth air-operated diaphragm valve 9, the eighth air-operated diaphragm valve 34, and the ninth air-operated diaphragm valve 35 are all closed. The seventh air-operated diaphragm valve 21 is in an open state.
Filter sterilization procedure:
the first air-operated diaphragm valve 1, the second air-operated diaphragm valve 2, the third air-operated diaphragm valve 3, the fourth air-operated diaphragm valve 4, the fifth air-operated diaphragm valve 7, the sixth air-operated diaphragm valve 9, the eighth air-operated diaphragm valve 34, and the ninth air-operated diaphragm valve 35 are all in the closed state. The seventh air-operated diaphragm valve 21 is in an open state.
The fifth pneumatic diaphragm valve 7 is opened, the temperature measured by the exhaust temperature sensor 5 rises to 121 ℃, timing is started, in the timing process, the fifth pneumatic diaphragm valve 7 and the fourth pneumatic diaphragm valve 4 are intermittently opened and closed, the opening and closing time ratio of the fifth pneumatic diaphragm valve 7 is larger than or equal to the opening and closing time ratio of the fourth pneumatic diaphragm valve 4, the opening and closing time ratio is the ratio of the opening time to the closing time in one opening and closing period, after 30 minutes of timing, the fifth pneumatic diaphragm valve 7 and the fourth pneumatic diaphragm valve 4 are closed, the sixth pneumatic diaphragm valve 9 is opened, and the temperature is naturally reduced until the temperature of the exhaust temperature sensor 5 is lower than 90 ℃, and then the sixth pneumatic diaphragm valve 9 is closed. The in-situ sterilization procedure of the first air filter 6 and the second air filter 8 is ended. The filter sterilization is completed during maintenance and new first air filter 6 and second air filter 8 can be replaced.
The foregoing disclosure is merely illustrative of preferred embodiments of the present invention, but the present invention is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the technical scope of the present invention should be included in the scope of the present invention. The scope of the invention should therefore be determined by the appended claims and by the modifications made without departing from the principle of the invention and shall fall within the scope of the invention.
Claims (5)
1. The biological safety type high-pressure sterilizer comprises a stainless steel cylindrical cavity (28), and is characterized in that two ends of the stainless steel cylindrical cavity (28) are open ends, two open ends of the stainless steel cylindrical cavity (28) are respectively provided with a door plate in a sealing and pressing mode, an outer ring mounting groove (41) and an inner ring mounting groove (42) are formed in an annular end face (46) of the open end of the stainless steel cylindrical cavity (28), an outer ring sealing ring (43) is arranged in the outer ring mounting groove (41), an inner ring sealing ring (44) is arranged in the inner ring mounting groove (42), an air charging groove (45) is formed in the annular end face (46) of the open end of the stainless steel cylindrical cavity (28) between the outer ring mounting groove (41) and the inner ring mounting groove (42), and the door plate is in sealing fit with the outer ring sealing ring (43) and the inner ring sealing ring (44),
an air charging port and an air discharging port are arranged on the air charging groove (45), the air charging port is connected with a compressed air source through a second pneumatic diaphragm valve (2), the air charging port is also connected with an air outlet of the steam generator (30) through a first pneumatic diaphragm valve (1), the air discharging port is connected with a hot air inlet of a water-cooled heat exchanger (36) through a ninth pneumatic diaphragm valve (35), a hot air outlet of the water-cooled heat exchanger (36) is connected with a water-sealed vacuum pump (37),
the bottom of the stainless steel cylindrical cavity (28) is provided with a cavity steam inlet (27), the top of the stainless steel cylindrical cavity (28) is provided with a cavity air outlet (22), a jacket (26) is sleeved on the stainless steel cylindrical cavity (28), an air outlet of the steam generator (30) is connected with one end of a third pneumatic diaphragm valve (3), the other end of the third pneumatic diaphragm valve (3) is respectively connected with an air inlet of the jacket (26), an air inlet of the jacket (26) is provided with a jacket temperature sensor (16) and a first safety valve (17), an air outlet of the jacket (26) is connected with the cavity steam inlet (27) sequentially through a one-way valve (33) and an eighth pneumatic diaphragm valve (34), an air outlet of the jacket (26) is provided with a second drain valve (32),
the cavity exhaust port (22) is connected with one end of a fourth pneumatic diaphragm valve (4), an exhaust temperature sensor (5) is arranged at the other end of the fourth pneumatic diaphragm valve (4) and is connected with one end of a first air filter (6), the other end of the first air filter (6) is connected with one end of a second air filter (8), the other end of the second air filter (8) is respectively connected with one end of a fifth pneumatic diaphragm valve (7) and one end of a sixth pneumatic diaphragm valve (9), the other end of the fifth pneumatic diaphragm valve (7) is connected with an air outlet of a steam generator (30), and the other end of the sixth pneumatic diaphragm valve (9) is connected with a hot air inlet of a water-cooled heat exchanger (36) through an activated carbon filter (10).
2. A bio-safe autoclave as claimed in claim 1, wherein the steam generator (30) is provided with a second safety valve (29) at its outlet and the steam generator (30) is further provided with a first drain valve (31) at its outlet.
3. A bio-safe autoclave as claimed in claim 2, further comprising an intra-cavity pressure sensor (14) for measuring the pressure in the stainless steel cylindrical cavity (28), and intra-cavity temperature sensors (15, 19) for measuring the temperature in the stainless steel cylindrical cavity (28), and a needle temperature sensor (18) for measuring the temperature of the articles to be sterilized in the stainless steel cylindrical cavity (28).
4. A bio-safe autoclave as claimed in claim 3, wherein the stainless steel cylindrical chamber (28) is further provided with an external air inlet hole, the external air inlet hole is connected with one end of the third air filter (20), and a seventh pneumatic diaphragm valve (21) is arranged at the other end of the third air filter (20).
5. A method of bio-safe autoclaving using the bio-safe autoclave of claim 4, comprising the steps of:
step 1, setting a first pneumatic diaphragm valve (1), a second pneumatic diaphragm valve (2), a third pneumatic diaphragm valve (3), a fourth pneumatic diaphragm valve (4), a fifth pneumatic diaphragm valve (7), a sixth pneumatic diaphragm valve (9), an eighth pneumatic diaphragm valve (34) and a ninth pneumatic diaphragm valve (35) to be in a closed state, and setting a seventh pneumatic diaphragm valve (21) to be in an open state;
step 2, generating steam by the steam generator (30) through electric heating, wherein the temperature range is 135-138 ℃ and the steam is maintained at 3.5bar;
step 3, placing the to-be-sterilized object into a stainless steel cylindrical cavity (28), inserting a needle-type temperature sensor (18) into the to-be-sterilized object, and sealing and pressing two open ends of the stainless steel cylindrical cavity (28) to form a first door plate (11) and a second door plate (25);
step 4, opening the first pneumatic diaphragm valve (1) and the ninth pneumatic diaphragm valve (35), and closing the ninth pneumatic diaphragm valve (35) after waiting for 5 minutes;
step 5, opening a fourth pneumatic diaphragm valve (4) and a sixth pneumatic diaphragm valve (9), starting a water-sealed vacuum pump (37) to vacuumize, and stopping vacuumizing when the vacuum degree of the cavity of the stainless steel cylindrical cavity (28) is lower than 0.1 bar;
step 6, opening a third pneumatic diaphragm valve (3), and heating the jacket temperature sensor (16) to the temperature of 123 ℃ required by sterilization and heating;
step 7, opening an eighth pneumatic diaphragm valve (34), closing a seventh pneumatic diaphragm valve (21), enabling steam in a jacket (26) to enter a cavity of a stainless steel cylindrical cavity (28) through a one-way valve (33), and heating temperature sensors (15, 19) in the cavity to 115 ℃;
step 8, intermittently opening and closing an eighth pneumatic diaphragm valve (34) and a fourth pneumatic diaphragm valve (4), wherein the opening and closing time ratio of the eighth pneumatic diaphragm valve (34) is greater than or equal to the opening and closing time ratio of the fourth pneumatic diaphragm valve (4), and the opening and closing time ratio is the ratio of the opening time to the closing time in one opening and closing period, so that the temperature measured by the needle type temperature sensor (18) is maintained between 121 ℃ and 123 ℃;
step 9, maintaining the temperature measured by the needle temperature sensor (18) at 121 ℃ to 123 ℃ for 30 minutes, and finishing sterilization maintenance;
step 10, the first pneumatic diaphragm valve (1), the third pneumatic diaphragm valve (3) and the eighth pneumatic diaphragm valve (34) are closed;
step 11, a ninth pneumatic diaphragm valve (35), a fourth pneumatic diaphragm valve (4) and a sixth pneumatic diaphragm valve (9) are opened, a water-sealed vacuum pump (37) is started to carry out vacuumizing drying, tail gas in a stainless steel cylindrical cavity is discharged through a cavity exhaust port (22), sequentially passes through a first air filter (6), a second air filter (8) and an activated carbon filter (10), is cooled by a water-cooled heat exchanger (36), and is discharged by the water-sealed vacuum pump (37); the vacuum pumping of the water-sealed vacuum pump (37) reduces the pressure in the stainless steel cylinder-shaped cavity to below 0.1bar, and the drying is finished after 5 minutes; closing the ninth air-operated diaphragm valve (35);
step 12, closing a water seal type vacuum pump (36), opening a seventh pneumatic diaphragm valve (21) and a second pneumatic diaphragm valve (2), and enabling external air to enter a stainless steel cylinder cavity through a third air filter (20); compressed air of a compressed air source enters an inflation groove between the outer ring installation groove and the inner ring installation groove through the second pneumatic diaphragm valve (2), after the compressed air is maintained for 2 minutes, the second pneumatic diaphragm valve (2) is closed, the ninth pneumatic diaphragm valve (35) is opened, and the pressure in the inflation groove is restored to be balanced with the atmospheric pressure;
step 13, the second pneumatic diaphragm valve (2), the fourth pneumatic diaphragm valve (4), the sixth pneumatic diaphragm valve (9) and the ninth pneumatic diaphragm valve (35) are all closed, and the first door plate (11) or the second door plate (25) is opened.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910325059.0A CN109966535B (en) | 2019-04-22 | 2019-04-22 | Biological safety type high-pressure sterilizer and sterilization method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910325059.0A CN109966535B (en) | 2019-04-22 | 2019-04-22 | Biological safety type high-pressure sterilizer and sterilization method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109966535A CN109966535A (en) | 2019-07-05 |
| CN109966535B true CN109966535B (en) | 2023-04-25 |
Family
ID=67085634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910325059.0A Active CN109966535B (en) | 2019-04-22 | 2019-04-22 | Biological safety type high-pressure sterilizer and sterilization method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109966535B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476621A (en) * | 2021-06-07 | 2021-10-08 | 湖南杰萃生物技术有限公司 | Sterilization method of plant raw material |
| CN113632778A (en) * | 2021-06-30 | 2021-11-12 | 北京长丰诚耀技术服务中心 | Four-in-one sterilization and killing device and movable sterilization and killing vehicle |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4108601A (en) * | 1976-12-29 | 1978-08-22 | Better Built Machinery Corporation | Steam sterilizing apparatus |
| US4238447A (en) * | 1978-05-31 | 1980-12-09 | Better Built Machinery Corporation | Steam sterilizing process |
| JPH11206865A (en) * | 1998-01-22 | 1999-08-03 | Masayuki Koseki | Deodorization of high pressure steam sterilizer |
| CN2728607Y (en) * | 2004-09-28 | 2005-09-28 | 北京中环联合环境工程有限公司 | Device for treating harmful tailgas of medical waste matter disinfection and sterilization |
| DE102006034527A1 (en) * | 2006-07-26 | 2008-01-31 | Werner Ulschmid | Rectangular sterile container for e.g. medical cutlery, has vacuum chamber surrounded by seal and attached to check valve that permits evacuation of vacuum chamber by outside negative pressure, where seal is inserted into contact surface |
| CN201200631Y (en) * | 2008-05-29 | 2009-03-04 | 山东新华医疗器械股份有限公司 | Biosafety steam sterilizer |
| CN103330953A (en) * | 2013-06-10 | 2013-10-02 | 山东威高集团医用高分子制品股份有限公司 | Biosafety type pulsation vacuum sterilizer |
| CN103480017A (en) * | 2013-09-18 | 2014-01-01 | 连云港佑源医药设备制造有限公司 | Online sealing steam disinfection and sterilization device |
| CN206816119U (en) * | 2017-05-12 | 2017-12-29 | 上海开纯洁净室技术工程有限公司 | Double bolloon seal pressure differential gas-tight door |
-
2019
- 2019-04-22 CN CN201910325059.0A patent/CN109966535B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4108601A (en) * | 1976-12-29 | 1978-08-22 | Better Built Machinery Corporation | Steam sterilizing apparatus |
| US4238447A (en) * | 1978-05-31 | 1980-12-09 | Better Built Machinery Corporation | Steam sterilizing process |
| JPH11206865A (en) * | 1998-01-22 | 1999-08-03 | Masayuki Koseki | Deodorization of high pressure steam sterilizer |
| CN2728607Y (en) * | 2004-09-28 | 2005-09-28 | 北京中环联合环境工程有限公司 | Device for treating harmful tailgas of medical waste matter disinfection and sterilization |
| DE102006034527A1 (en) * | 2006-07-26 | 2008-01-31 | Werner Ulschmid | Rectangular sterile container for e.g. medical cutlery, has vacuum chamber surrounded by seal and attached to check valve that permits evacuation of vacuum chamber by outside negative pressure, where seal is inserted into contact surface |
| CN201200631Y (en) * | 2008-05-29 | 2009-03-04 | 山东新华医疗器械股份有限公司 | Biosafety steam sterilizer |
| CN103330953A (en) * | 2013-06-10 | 2013-10-02 | 山东威高集团医用高分子制品股份有限公司 | Biosafety type pulsation vacuum sterilizer |
| CN103480017A (en) * | 2013-09-18 | 2014-01-01 | 连云港佑源医药设备制造有限公司 | Online sealing steam disinfection and sterilization device |
| CN206816119U (en) * | 2017-05-12 | 2017-12-29 | 上海开纯洁净室技术工程有限公司 | Double bolloon seal pressure differential gas-tight door |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109966535A (en) | 2019-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109966535B (en) | Biological safety type high-pressure sterilizer and sterilization method | |
| CN204319330U (en) | A kind of edible fungi sterilization device | |
| CN102018970B (en) | Sterilization process and equipment of absorbable sutures | |
| MX2009005273A (en) | Apparatus and method for sterilizing items. | |
| CN104083781A (en) | Sterilization method of steam sterilizer and steam sterilizer | |
| CN102743773A (en) | Ethylene oxide preheating, sterilization and resolution integrated cabinet and sterilizing method | |
| CN102350003B (en) | Hydrogen peroxide low-temperature sterilizing equipment and use method thereof | |
| CN103418002A (en) | Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device | |
| CN203417350U (en) | Steam disinfector | |
| CN204514548U (en) | A kind of sterilizing leakage detection apparatus be applied in injection production run | |
| CN101121028A (en) | Sealing device for door of steam sterilization cabinet | |
| CN201624119U (en) | High-pressure carbon dioxide sterilizer | |
| CN104721856A (en) | Explosion-proof bag sterilization cabinet adaptive to sealed packaging bag sterilization, method and application | |
| CN210078382U (en) | Biological safety type high-pressure sterilizer | |
| CN210873150U (en) | High-pressure sterilizer of steam protection sterilization process door | |
| CN103110970B (en) | Vacuum type transmission device for vaporization hydrogen peroxide sterilization | |
| CN103480017A (en) | Online sealing steam disinfection and sterilization device | |
| CN203089978U (en) | Vacuum delivery device with vapor hydrogen peroxide sterilization | |
| CN209075537U (en) | Chinese patent drug sterilizing cabinet | |
| CN204542936U (en) | Be applicable to the explosion-proof bag sterilizing cabinet of sealed packing bag sterilizing | |
| CN212282221U (en) | Vertical pressure steam sterilizer with safety exhaust and filter online sterilization | |
| CN208191620U (en) | A kind of lightweight bacteria stick bactericidal unit | |
| CN212522494U (en) | Low-concentration formaldehyde sterilization system | |
| CN207384510U (en) | A kind of high-pressure sterilizing pot | |
| CN211535745U (en) | Steam sterilizer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |