CN109966326A - A kind of extracting method of indigo plant potted flower tannin - Google Patents
A kind of extracting method of indigo plant potted flower tannin Download PDFInfo
- Publication number
- CN109966326A CN109966326A CN201910307979.XA CN201910307979A CN109966326A CN 109966326 A CN109966326 A CN 109966326A CN 201910307979 A CN201910307979 A CN 201910307979A CN 109966326 A CN109966326 A CN 109966326A
- Authority
- CN
- China
- Prior art keywords
- potted flower
- tannin
- blue potted
- blue
- extracting
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The present invention relates to a kind of extracting methods of blue potted flower tannin, it is characterised in that using the blue potted flower just picked as raw material, using 85% aqueous acetone solution as entrainer, using the tannin in supercritical carbon dioxide extracting indigo plant potted flower.This method compensates for the blank of blue potted flower tannin extraction process, and significantly improve blue potted flower tannin yield, it is substantially reduced impurity component brought by traditional extraction technique, and easy to operate, favorable reproducibility, be free of toxic organic solvents, it is avoided that environmental pollution, operation is continuous, is easy to amplify, and lays a good foundation for the pharmacological action and blue potted flower new drug development of blue potted flower tannin.
Description
Technical field
The present invention relates to a kind of extracting methods of blue potted flower tannin, belong to anaesthetic development technique field, are exclusively used in anaesthetic indigo plant
The extraction purification of potted flower tannin.
Background technique
Blue potted flower be Dipsacaceae plant narrow leaf indigo plant potted flower (Scabiosa comosa Fisch. ex Roem.et
Schult) and Scabiosa tschiliensis (Scabiosa tschiliensis Grunning drying titbit).The anaesthetic name of blue potted flower
It is anaesthetic specific breed for " Tao Sen-Tao Mo ", has effects that heat-clearing, clear " association's day ", be usually used in lung heat, liver heat, throat heat
Etc. diseases, cure mainly the diseases such as irascibility headache, fever, cough with lung heat, jaundice.
Mongolian medicine's clinical application show blue potted flower have exact clinical efficacy, containing flavonoids, triterpenoid saponin, organic acid,
A variety of chemical components such as phenols, tannin, alkaloid, protein.Modern pharmacological studies have shown that tannin has antibacterial, anti-inflammatory, disease-resistant
The effects of malicious, anti-oxidant, antiallergic action, astringing to arrest bleeding, antidiarrheal, expelling parasite, also can be used as the solution of alkaloid or heavy metal poisoning
Toxic agent.And the research about blue potted flower chemical component, flavones ingredient is had focused largely on, it is very few to its tannin research, especially not
See the report of blue potted flower tannin extracting method.And often yield is lower for traditional tannin extraction process, is badly in need of at present a kind of efficient
The method for extracting blue potted flower tannin.
Summary of the invention
The object of the present invention is to provide a kind of efficient blue potted flower tannin extracting methods, make up blue potted flower tannin enrichment
Blank, further to study the pharmacological action of blue potted flower tannin and chemical structure, expanding blue potted flower clinical application and blue potted flower
New drug development lays the foundation.The blue potted flower tannin extracting method is as follows: the blue potted flower that will have just picked sets overcritical dioxy
Change carbon extractor in, using 70~90% acetone as entrainer, entrainer flow velocity be 6~10ml/min, adjust extraction temperature be 55~
65 DEG C, extracting pressure is 25~35MPa, and carbon dioxide flow rate is 60~80g/min, extraction time 60min~120min, is collected
Blue potted flower tannin extract measures content of tannin.
The optimal processing parameter of the preferred blue potted flower tannin extracting method of the present invention are as follows: raw material is the blue basin just picked
Flower, entrainer are 85% acetone, and entrainer flow velocity is 9ml/min, and extraction temperature is 60 DEG C, extracting pressure 35MPa, titanium dioxide
Carbon flow speed is 68g/min, extraction time 90min.
Specific embodiment
Embodiment 1 weighs the blue potted flower 100g just picked, sets in supercritical extract device, and setting extracting pressure is 35
MPa, extraction temperature are 60 DEG C, 85% acetone are added in extractor as entrainer by high-pressure pump, flow velocity is set as 9ml/
Min, carbon dioxide flow rate 68g/min after extracting 90min, stop extraction, collect blue potted flower tannin, and carry out assay,
Measuring blue potted flower content of tannin is 10.02mg/100g.
Embodiment 2 weighs the blue potted flower 100g just picked, sets in supercritical extract device, and setting extracting pressure is 25
MPa, extraction temperature are 60 DEG C, 70% acetone are added in extractor as entrainer by high-pressure pump, flow velocity is set as 7ml/
Min, carbon dioxide flow rate 60g/min after extracting 90min, stop extraction, collect blue potted flower tannin, and carry out assay,
Measuring blue potted flower content of tannin is 7.51mg/100g.
Embodiment 3 weighs the blue potted flower 100g just picked, sets in supercritical extract device, and setting extracting pressure is 30
MPa, extraction temperature are 55 DEG C, 85% acetone are added in extractor as entrainer by high-pressure pump, flow velocity is set as 9ml/
Min, carbon dioxide flow rate 68g/min after extracting 90min, stop extraction, collect blue potted flower tannin, and carry out assay,
Measuring blue potted flower content of tannin is 8.09mg/100g.
Embodiment 4 weighs the blue potted flower 100g just picked, sets in supercritical extract device, and setting extracting pressure is 35
MPa, extraction temperature are 60 DEG C, 90% acetone are added in extractor as entrainer by high-pressure pump, flow velocity is set as 6ml/
Min, carbon dioxide flow rate 68g/min after extracting 60min, stop extraction, collect blue potted flower tannin, and carry out assay,
Measuring blue potted flower content of tannin is 6.37mg/100g.
Embodiment 5 weighs the blue potted flower 100g just picked, sets in supercritical extract device, and setting extracting pressure is 35
MPa, extraction temperature are 65 DEG C, 85% acetone are added in extractor as entrainer by high-pressure pump, flow velocity is set as 9ml/
Min, carbon dioxide flow rate 80g/min after extracting 120min, stop extraction, collect blue potted flower tannin, and carry out content survey
Fixed, measuring blue potted flower content of tannin is 9.86mg/100g.
Embodiment 6 weighs the blue potted flower 100g just picked, adds 85% aqueous acetone solution 300ml, and ultrasound mentions
90min is taken, 40 DEG C of ultrasonic temperature, is filtered while hot, is concentrated, and carry out assay, measures blue potted flower tan
Matter content is 3.70mg/100g.
Claims (1)
1. a kind of extracting method of indigo plant potted flower tannin, its step are as follows: the blue potted flower just picked is set supercritical carbon dioxide
In extractor, using 85% aqueous acetone solution as entrainer, entrainer flow velocity is 9ml/min, and adjusting extraction temperature is 60 DEG C, extraction
Pressure is 35MPa, carbon dioxide flow rate 68g/min, extraction time 90min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910307979.XA CN109966326A (en) | 2019-04-17 | 2019-04-17 | A kind of extracting method of indigo plant potted flower tannin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910307979.XA CN109966326A (en) | 2019-04-17 | 2019-04-17 | A kind of extracting method of indigo plant potted flower tannin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109966326A true CN109966326A (en) | 2019-07-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910307979.XA Pending CN109966326A (en) | 2019-04-17 | 2019-04-17 | A kind of extracting method of indigo plant potted flower tannin |
Country Status (1)
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641387A (en) * | 2012-05-03 | 2012-08-22 | 天津大学 | Method for supercritically extracting natural activity ingredient oil tea polyphenol from oil tea fruits |
| CN102648939A (en) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | Preparation method for geum aleppicum polyphenol |
-
2019
- 2019-04-17 CN CN201910307979.XA patent/CN109966326A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102648939A (en) * | 2011-02-25 | 2012-08-29 | 苏州宝泽堂医药科技有限公司 | Preparation method for geum aleppicum polyphenol |
| CN102641387A (en) * | 2012-05-03 | 2012-08-22 | 天津大学 | Method for supercritically extracting natural activity ingredient oil tea polyphenol from oil tea fruits |
Non-Patent Citations (3)
| Title |
|---|
| 关健等: "鞣质提取方法的研究进展 ", 《黑龙江医药》 * |
| 蔡津生等: "《中国食药用菌工程学》", 31 January 2015, 上海科学技术文献出版社 * |
| 韩丹等: "蒙药材蓝盆花有效成分的初步研究 ", 《内蒙古医学院学报》 * |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190705 |
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| WD01 | Invention patent application deemed withdrawn after publication |