CN109943476A - A kind of genetic chip sequencing equipment - Google Patents
A kind of genetic chip sequencing equipment Download PDFInfo
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- CN109943476A CN109943476A CN201910305711.2A CN201910305711A CN109943476A CN 109943476 A CN109943476 A CN 109943476A CN 201910305711 A CN201910305711 A CN 201910305711A CN 109943476 A CN109943476 A CN 109943476A
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- chip
- fixed
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- mounting
- fixed station
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Abstract
The invention discloses a kind of genetic chip sequencing equipments, two-dimensional movement platform, chip fixed station, intermittent motion mechanism and detachable fixing mechanism including chip；By be arranged in two-dimensional movement platform can intermittent rotary chip fixed station automatically switch chip when being sequenced；The characteristics of present invention has structure simple, stable, high production efficiency.
Description
Technical field
The present invention relates to a kind of genetic chip sequencing equipments.
Background
The development of detection device based on micro-array chip has greatly changed the looks of biotechnology industry.These
Equipment to detect a variety of biological samples simultaneously, detects rare source of people transcript.In the case where exciting light action, chip
On fluorescence probe launch Stokes shift light, and the transmitting light is then acquired by photomultiplier tube.So obtain micro- battle array
The information of column chip can service for a variety of researchs, such as gene expression research, variation research, Genotyping, and mononucleotide is more
State property, protein-interacting, there are also the diagnosing and treatings of disease.Sometimes for various chips into information collection, but it is existing
Device need to remove chip when having acquired a chip and change new chip and be acquired, in the process of replacement chip
In it is time-consuming and laborious, seriously affect working efficiency.
Summary of the invention
The purpose of the present invention is to solve the above the deficiencies in the prior art, provide a kind of genetic chip sequencing equipment.
The technical scheme adopted by the invention is that a kind of such, genetic chip sequencing equipment, the two dimension including chip is moved
Moving platform, chip fixed station, intermittent motion mechanism and detachable fixing mechanism；
The two-dimensional movement platform includes the clevis mounting of workbench and setting on the table；The clevis mounting is opened
The two sides Kou Chu are provided with the downward upper hopper chute of notch, and two upper hopper chute is connected by cylinder guide；The cylinder is led
It is arranged with sleeve on bar, longitudinal push rod is connected on the sleeve, the longitudinal push rod is driven by longitudinal motor, the longitudinal direction
Motor is fixed on the table by longitudinally fixed seat, and the two upper hopper chutes back-off is in simultaneously energy is opposite on the inner side edge of two gliding grooves
In the inner side edge longitudinal sliding motion of two gliding grooves, gliding groove both ends bottom is respectively arranged with sliding block；The sliding block and setting exist
Two slideways on workbench match merging can be relative to slideway transverse movement；The gliding groove lateral center is connected with cross
To push rod, the transverse direction push rod is driven by cross motor, and the cross motor is fixed on the table by transverse holder；
The chip fixed station is the strip polyhedral structure being fixed on clevis mounting, in the side of chip fixed station
It is respectively arranged with chip fixed groove on face, is provided with the rotary shaft through entire chip fixed station, chip in the longitudinal direction
Fixed station can be rotated with rotary shaft；The rotary shaft is stuck in the supporting table being fixed on clevis mounting, and passes through interval
Movement mechanism carries out intermittent rotary；
The intermittent motion mechanism includes the sheave being fixed in chip fixed station rotary shaft and the master by small machine driving
Dynamic driver plate composition, the sheave are made of radial slot and recessed Locking arc, the radial slot number of sheave and the side of chip fixed station
Number is identical；The active driver plate is made of pedestal with the straight pin and convex Locking arc being set on the base, the recessed Locking arc
It cooperates with convex Locking arc, straight pin and radial slot cooperate；The small machine is fixed on U by detachable fixing mechanism
In shape mounting base；
Preferably, the detachable fixing mechanism includes motor cabinet, fixed pin and clevis mounting, in the electricity of clevis mounting
Machine installation site is provided with mounting groove, installs and is provided with pin hole one in groove sidewall, and motor clevis mounting is inserted into mounting groove；Institute
It states and is provided with the pin hole two matched with pin hole on the part of motor clevis mounting insertion mounting groove；Fixed pin sequentially passes through pin
Motor cabinet is fixed on clevis mounting by Kong Yi, pin hole two.
Preferably, the radial slot number of the sheave and the side number of chip fixed station are 4.
Preferably, retarder is provided between the motor output shaft and active driver plate.
Preferably, the transverse direction, longitudinal motor are DFGA37R miniature linear.
Preferably, the small machine is Risym R300C miniature DC motor.
Preferably, buckle is provided in the chip fixing groove.
Preferably, the small machine is fixed by screws on motor cabinet.
The utility model has the advantages that
The present invention realizes genetic chip fast moving in two-dimensional surface by two-dimensional movement platform, convenient for positioning, leads to
It crosses to be provided with the rotatable chip fixed station for changing piece and realize and is quickly switched into another after the sequencing is completed in a genetic chip
The function of chip, while chip fixed station of the invention can also be dismantled, convenient for the installation of genetic chip；The present invention has structure
Simply, stable, the characteristics of high production efficiency.
Detailed description of the invention
Fig. 1 is structure of the invention figure；
Fig. 2 is clevis mounting and chip fixed station top view；
Fig. 3 is intermittent motion mechanism's schematic diagram；
Fig. 4 is detachable fixing mechanism schematic diagram；
1. workbench, 2.U shape mounting base, 3. upper hopper chutes, 4. cylinder guides, 5. sleeves, 6. longitudinal push rods, 7 longitudinal electricity
Machine, 8. longitudinally fixed seats, 9. gliding grooves, 10. sliding blocks, 11. slideways, 12. lateral push rods, 13. cross motors, 14. are laterally fixed
Seat, 15. chip fixed stations, 16. chip fixing grooves, 17. rotary shafts, 18. supporting tables, 19. sheaves, 20. small machines, 21. are actively
Driver plate, 22. radial slots, 23. recessed Locking arcs, 24. pedestals, 25. straight pins, 26. convex Locking arcs, 27. motor cabinets, 28. fixed pins,
29. retarder.
Specific embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment and attached drawing, the invention will be further described, should
The examples are only for explaining the invention, is not intended to limit the scope of the present invention..
As shown in Figs 1-4, a kind of genetic chip sequencing equipment, two-dimensional movement platform, chip fixed station including chip,
It has a rest movement mechanism and detachable fixing mechanism；
The two-dimensional movement platform includes workbench 1 and the clevis mounting 2 that is arranged on workbench 1；The U-shaped installation
2 opening two sides of seat are provided with the downward upper hopper chute 3 of notch, and two upper hopper chute 3 is connected by cylinder guide 4；Described
It is arranged with sleeve 5 on cylinder guide 4, longitudinal push rod 6 is connected on the sleeve 5, the longitudinal push rod 6 is by longitudinal motor 7
Driving, the longitudinal motor 7 are fixed on workbench 1 by longitudinally fixed seat 8；The back-off of two upper hopper chute 3 is in two gliding grooves 9
Inner side edge on and cunning can be respectively arranged with relative to the inner side edge longitudinal sliding motion of two gliding grooves 9, the 9 both ends bottom of gliding groove
Block 10；The sliding block 10 and two slideways 11 being arranged on workbench 1 match merging can be relative to 11 transverse movement of slideway；Institute
9 lateral center of gliding groove stated is connected with lateral push rod 12, and the transverse direction push rod 12 is driven by cross motor 13, the transverse direction
Motor 13 is fixed on workbench 1 by transverse holder 14；
The chip fixed station 15 is the strip polyhedral structure being fixed on clevis mounting 2, in chip fixed station 15
Side on be respectively arranged with chip fixed groove 16, be provided with the rotary shaft through entire chip fixed station in the longitudinal direction
17, chip fixed station 15 can be rotated with rotary shaft 17；The rotary shaft 17 is stuck in the support being fixed on clevis mounting 2
On platform 18, and intermittent rotary is carried out by intermittent motion mechanism；
The intermittent motion mechanism includes the sheave 19 being fixed in 15 rotary shaft 17 of chip fixed station and by small machine 20
The active driver plate 21 of driving forms, and the sheave 19 is made of radial slot 22 and recessed Locking arc 23, the number of radial slot 22 of sheave 19
Mesh is identical with the side number of chip fixed station 15；The active driver plate 21 is by pedestal 24 and the straight pin being arranged on pedestal 24
25 and convex Locking arc 26 form, the recessed Locking arc 23 and convex Locking arc phase 26 mutually cooperate, and straight pin 25 and radial slot 22 are mutual
Cooperation；The small machine 20 is fixed on clevis mounting 2 by detachable fixing mechanism；
The detachable fixing mechanism includes motor cabinet 27, fixed pin 28 and clevis mounting 2 in the present embodiment, in U-shaped
The mounting position of motor of mounting base 2 is provided with mounting groove, installs and is provided with pin hole one in groove sidewall, and motor cabinet 27 is inserted into mounting groove
In；The pin hole two matched with pin hole is provided on the part of the motor cabinet insertion mounting groove；Fixed pin 28 sequentially passes through pin
Motor cabinet 27 is fixed on clevis mounting 2 by Kong Yi, pin hole two, 22 number of radial slot and chip fixed station of the sheave 19
15 side number is 4, and retarder 29, the transverse direction, Zong Xiang electricity are provided between the motor output shaft and active driver plate 21
Machine is DFGA37R miniature linear, and the small machine 20 is Risym R300C miniature DC motor, and the chip is fixed
Buckle is provided on slot 16, the small machine 17 is fixed by screws on motor cabinet 27.
Pushrod movement is driven by lateral, longitudinal motor when in use, push rod band movable slider moves on the slide rail, U-shaped peace
Filling seat drives the genetic chip in chip fixed station to move, to realize fast and effective shifting of the genetic chip in two-dimensional surface
It is dynamic, current chip after the sequencing is completed, start small machine, small machine drives the active driver plate rotation of intermittent motion mechanism, actively
Straight pin on driver plate enters before the radial slot on sheave, and convex Locking arc locks recessed Locking arc, then sheave is stationary.Circle
When pin enters radial slot, convex, recessed Locking arc is just separated, and straight pin can be rotated with driving sheave.When straight pin is detached from radial direction
When slot, convex Locking arc again locks recessed Locking arc, thus keep sheave stationary, therefore, when active driver plate makees continuous rotation,
Sheave, which is driven, makees unidirectional intermittent rotary；The sheave that active driver plate per revolution and active driver plate match rotates 90 °,
To drive the rotary shaft mutually fixed with sheave rotation, so that the genetic chip of chip fixed station another side is gone to top surface and surveyed
Sequence.
When needing replacing genetic chip, will can first be fixed on the small machine on motor clevis mounting and active driver plate from
Installation removes, and can thus take chip fixed station away from clevis mounting and carry out chip replacement, convenient and efficient.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of genetic chip sequencing equipment, which is characterized in that two-dimensional movement platform, chip fixed station, interval including chip
Movement mechanism and detachable fixing mechanism；
The two-dimensional movement platform includes the clevis mounting of workbench and setting on the table；The clevis mounting opening
Two sides are provided with the downward upper hopper chute of notch, and two upper hopper chute is connected by cylinder guide；On the cylinder guide
It is arranged with sleeve, longitudinal push rod is connected on the sleeve, the longitudinal push rod is driven by longitudinal motor, the longitudinal motor
It is fixed on the table by longitudinally fixed seat；Two upper hopper chute back-off is on the inner side edge of two gliding grooves and can be relative to two
The inner side edge longitudinal sliding motion of gliding groove, gliding groove both ends bottom are respectively arranged with sliding block；The sliding block and setting are working
Two slideways on platform match merging can be relative to slideway transverse movement；The gliding groove lateral center, which is connected with, laterally to be pushed away
Bar, the transverse direction push rod are driven by cross motor, and the cross motor is fixed on the table by transverse holder；
The chip fixed station is the strip polyhedral structure being fixed on clevis mounting, on the side of chip fixed station
It is respectively arranged with chip fixed groove, is provided with the rotary shaft through entire chip fixed station in the longitudinal direction, chip is fixed
Platform can be rotated with rotary shaft；The rotary shaft is stuck in the supporting table being fixed on clevis mounting, and passes through intermittent movement
Mechanism carries out intermittent rotary；
The intermittent motion mechanism includes the sheave being fixed in chip fixed station rotary shaft and is dialled by the active of small machine driving
Disk composition, the sheave are made of radial slot and recessed Locking arc, the radial slot number of sheave and the side number of chip fixed station
It is identical；The active driver plate is made of pedestal with the straight pin and convex Locking arc being set on the base, the recessed Locking arc and convex
Locking arc cooperates, and straight pin and radial slot cooperate；The small machine is fixed on U-shaped peace by detachable fixing mechanism
It fills on seat.
2. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the detachable fixing mechanism includes
Motor cabinet, fixed pin and clevis mounting are provided with mounting groove in the mounting position of motor of clevis mounting, install and set in groove sidewall
It is equipped with pin hole one, motor clevis mounting is inserted into mounting groove；It is arranged on the part of the motor clevis mounting insertion mounting groove
There is the pin hole two matched with pin hole；Fixed pin sequentially passes through pin hole one, motor cabinet is fixed on clevis mounting by pin hole two.
3. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the radial slot number of the sheave and
The side number of chip fixed station is 4.
4. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the motor output shaft and active are dialled
Retarder is provided between disk.
5. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the transverse direction, longitudinal motor are
DFGA37R miniature linear.
6. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the small machine is Risym
R300C miniature DC motor.
7. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that be provided in the chip fixing groove
Buckle.
8. a kind of genetic chip sequencing equipment as described in claim 1, which is characterized in that the small machine is fixed by screw
On motor cabinet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910305711.2A CN109943476A (en) | 2019-04-16 | 2019-04-16 | A kind of genetic chip sequencing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910305711.2A CN109943476A (en) | 2019-04-16 | 2019-04-16 | A kind of genetic chip sequencing equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109943476A true CN109943476A (en) | 2019-06-28 |
Family
ID=67014251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910305711.2A Pending CN109943476A (en) | 2019-04-16 | 2019-04-16 | A kind of genetic chip sequencing equipment |
Country Status (1)
| Country | Link |
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| CN (1) | CN109943476A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022089647A1 (en) * | 2020-11-02 | 2022-05-05 | Mgi Tech Co., Ltd. | Sequencing systems and methods utilizing non-planar substrates |
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| EP1154259A1 (en) * | 2000-05-11 | 2001-11-14 | Fuji Photo Film Co., Ltd. | Measuring chip |
| US20150260712A1 (en) * | 2012-09-28 | 2015-09-17 | Vibrant Holdings, Llc | Methods, Systems, and Arrays for Biomolecular Analysis |
| CN105273999A (en) * | 2015-10-30 | 2016-01-27 | 北京中科紫鑫科技有限责任公司 | Box-type DNA sequencer with fastening reaction bin |
| CN205528706U (en) * | 2016-03-28 | 2016-08-31 | 北京东方亚美基因科技研究院 | Carrier carousel for gene sequencer |
| CN205528708U (en) * | 2016-03-28 | 2016-08-31 | 北京东方亚美基因科技研究院 | Optics subassembly of taking a picture for gene sequencer |
| CN107446808A (en) * | 2017-08-23 | 2017-12-08 | 苏州思维医疗科技有限公司 | Gene sequencer |
| CN108760688A (en) * | 2018-02-13 | 2018-11-06 | 中国人民解放军91054部队 | A kind of detection and identification device of underwater micro- trace chemical |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1154259A1 (en) * | 2000-05-11 | 2001-11-14 | Fuji Photo Film Co., Ltd. | Measuring chip |
| US20150260712A1 (en) * | 2012-09-28 | 2015-09-17 | Vibrant Holdings, Llc | Methods, Systems, and Arrays for Biomolecular Analysis |
| CN105273999A (en) * | 2015-10-30 | 2016-01-27 | 北京中科紫鑫科技有限责任公司 | Box-type DNA sequencer with fastening reaction bin |
| CN205528706U (en) * | 2016-03-28 | 2016-08-31 | 北京东方亚美基因科技研究院 | Carrier carousel for gene sequencer |
| CN205528708U (en) * | 2016-03-28 | 2016-08-31 | 北京东方亚美基因科技研究院 | Optics subassembly of taking a picture for gene sequencer |
| CN107446808A (en) * | 2017-08-23 | 2017-12-08 | 苏州思维医疗科技有限公司 | Gene sequencer |
| CN108760688A (en) * | 2018-02-13 | 2018-11-06 | 中国人民解放军91054部队 | A kind of detection and identification device of underwater micro- trace chemical |
Non-Patent Citations (3)
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| 付云博 等: "基因测序仪运动平台的高精度定位控制", 《光学 精密工程》 * |
| 周正元: "《机械制造基础》", 31 August 2008, 电子科技大学出版社 * |
| 牛礼军: "基于液体透镜的激光诱导荧光检测装置", 《中国优秀博硕士学位论文全文数据库(硕士)信息科技辑》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022089647A1 (en) * | 2020-11-02 | 2022-05-05 | Mgi Tech Co., Ltd. | Sequencing systems and methods utilizing non-planar substrates |
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Application publication date: 20190628 |
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