CN109939754A - A kind of liquid delivery module based on centrifugal force - Google Patents
A kind of liquid delivery module based on centrifugal force Download PDFInfo
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- CN109939754A CN109939754A CN201910290724.7A CN201910290724A CN109939754A CN 109939754 A CN109939754 A CN 109939754A CN 201910290724 A CN201910290724 A CN 201910290724A CN 109939754 A CN109939754 A CN 109939754A
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- Prior art keywords
- runner
- liquid
- syphon
- collecting chamber
- syphon runner
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- 239000007788 liquid Substances 0.000 title claims abstract description 72
- 238000005119 centrifugation Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 239000011859 microparticle Substances 0.000 description 14
- 239000012530 fluid Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000719199 Elagatis bipinnulata Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Abstract
The present invention relates to a kind of liquid delivery modules based on centrifugal force, it includes inlet chamber, discharge chambe, the first syphon runner and the second syphon runner that one end is connected with discharge chambe, the first collecting chamber being connected with the first syphon runner other end and the second collecting chamber being connected with the second syphon runner other end, second syphon runner is radially outer relative to the position of the first syphon runner, second syphon runner, second collecting chamber corresponding with the link position of the second collecting chamber is radially outer close to the side of axis of rotation, first syphon runner and axis of rotation are radially inner relative to the indoor liquid level of entrance apart from nearest position；The present invention is matched by discharge chambe with two syphon runners, the liquid being added from inlet chamber can be made to preferentially enter into the second collecting chamber, it is entered in the first collecting chamber from the liquid that inlet chamber is newly added, realizes the shunting effect of liquid, to meet the test request under specified conditions.
Description
Technical field
The present invention relates to a kind of liquid delivery modules based on centrifugal force.
Background technique
It, under certain condition, can be by the sample of addition in the liquid detection reagents disk used in biology, medical domain
This carries out quantitative, timing conveying, is reacted with meeting sample from different reagents with different proportions, while can also be to anti-
The time answered is controlled, and the continuous detection to single sample is realized.In this field, it needs to divide the liquid of addition
Stream, to meet more reaction test conditions.
Summary of the invention
Technical solution to be solved by this invention is to provide a kind of liquid delivery module based on centrifugal force, which can be with
The function of shunting is realized to the liquid of addition.
The technical scheme adopted by the invention is that: a kind of liquid delivery module based on centrifugal force comprising inlet chamber, with
Inlet chamber is connected for accepting the discharge chambe of the liquid from inlet chamber through centrifugation discharge, first that one end is connected with discharge chambe
Syphon runner and the second syphon runner, the first collecting chamber being connected with the first syphon runner other end and with the second siphon jet
The second collecting chamber that the road other end is connected, second syphon runner is radially outer relative to the position of the first syphon runner,
The link position of second syphon runner and the second collecting chamber is radial close to the side of axis of rotation relative to the second collecting chamber
Outer, the first syphon runner and axis of rotation are radially inner relative to the indoor liquid level of entrance apart from nearest position.
Further, inlet and first row port are provided in inlet chamber.
Further, second exhaust port is provided on first collecting chamber.
Further, third exhaust outlet is provided on second collecting chamber.
Further, the position of the discharge chambe is radially outer relative to inlet chamber.
Further, first syphon runner and the second syphon runner are inverted U shape.
Further, second collecting chamber is in I-shaped, the outboard cavity of second syphon runner and the second collecting chamber
Body is connected.
The positive effect of the present invention are as follows: the present invention is matched by discharge chambe with two syphon runners, can be made from entrance
The liquid that room is added is preferentially entered into the second collecting chamber, is entered in the first collecting chamber from the liquid that inlet chamber is newly added, real
The shunting effect of existing liquid, to meet the test request under specified conditions.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention.
Specific embodiment
First it should be noted that radially outer in the present invention and it is radial it is inner be rotary shaft relative to reagent disc
It says in mind.
As shown in Fig. 1, the present invention includes the reagent disc 13 by driving device driving rotation and is arranged in reagent disc 13
On inlet chamber 1, discharge chambe 3, the first syphon runner 4, the second syphon runner 5, the first collecting chamber 7 and the second collecting chamber 6.Entering
Have inlet 9 and first row port 8 on mouthful room 1, position of the discharge chambe 3 on reagent disc 13 relative to inlet chamber 1 radially outward,
Discharge chambe 3 crosses first runner 2 with inlet chamber 1 and is connected, and the junction of first runner 2 and inlet chamber 1 is located at inlet chamber 1 far from rotation
The side of the shaft heart is provided with second flow channel 11,4 He of the first syphon runner far from the side of axis of rotation in discharge chambe 3
One end of second syphon runner 5 is connected with second flow channel 11 respectively, the U-shaped bottom of the first syphon runner 4 and the second syphon runner 5
Portion is located at close to the side of axis of rotation, and second syphon runner 5 is radially leaned on relative to the position of the first syphon runner 4
Outside, it is connected separately with the first collecting chamber 7 and the second collecting chamber 6 in the other end of the first syphon runner 4 and the second syphon runner 5,
It is respectively arranged with second exhaust port 10 and third exhaust outlet 12 on the first collecting chamber 7 and the second collecting chamber 6 and connects it with atmosphere
It is logical.In I-shaped, second syphon runner 5 is connected second collecting chamber 6 with the outboard chambers of the second collecting chamber 6,
That is, the junction of the second syphon runner 5 and the second collecting chamber 6 is relative to the second collecting chamber 6 and axis of rotation apart from nearest one
Side is radially outer.
It is arranged out of second syphon runner 5 it should be noted that liquid is unrestricted in reagent disc rotary course in order to prevent
Out, the liquid level in inlet chamber 1 should be lower than the most radial inner position of the second syphon runner 5, that is to say, that the liquid in inlet chamber 1
The distance between face and axis of rotation are greater than the minimum range between the second syphon runner 5 and axis of rotation, otherwise inlet chamber 1
Interior liquid can be discharged out of second syphon runner 5 using siphon principle under the influence of centrifugal force.This situation goes out in order to prevent
It is existing, it can reduce distance between the second syphon runner 5 and axis of rotation, or even make between the second syphon runner 5 and axis of rotation
Distance be less than the distance between inlet 9 and axis of rotation or the second syphon runner 5 and the distance between axis of rotation is small
Minimum range between inlet chamber 1 and axis of rotation.
The function of separating liquid, specifically used method may be implemented in the present invention are as follows: Step 1: the revolving speed of reagent disc 13 is 0,
Liquid is injected into inlet chamber 1 by inlet 9, at this point, the liquid level in inlet chamber 1 is than the innermost portion of the second syphon runner 5
Divide more radially outer.Step 2: make reagent disc 13 with higher rotation speed (such as 60-90Hz, preferably use 75Hz), part liquid at this time
Body is flowed into discharge chambe 3, and the compressible medium (being in the present embodiment air) in discharge chambe 3 is compressed.Due to first,
Two syphon runners are more radial inner relative to the liquid level in inlet 9 near the part of inside, and liquid will not pass through two at this time
Syphon runner outflow.Then reagent disc 13 is quickly reduced and (such as carries out reduction of speed with 10-20Hz/s, preferably 15 Hz/s) to turn
Speed arrives 25-45Hz, preferably 35Hz, at this time compressed media expansion in discharge chambe 3, and the liquid in discharge chambe 3 is extruded,
The liquid of extrusion enters first runner 2, the first syphon runner 4 and the second syphon runner 5, until liquid passes through the second syphon runner
5 most radial inner positions then utilize siphon principle, and liquid is flowed into the second collecting chamber 6 by the second syphon runner 5,
The volume of second collecting chamber 6 is larger, can fully flow into from the liquid being added in inlet chamber 1 into the second collecting chamber 6.At this point, liquid
Body has certain liquid level in the second collecting chamber 6, according to U-tube principle, also can in the bottom of the second syphon runner 5
Some fluid column, the height of the fluid column is identical as the liquid level in the second collecting chamber 6, so that the second syphon runner 5 be blocked up
Firmly.Step 3: adding liquid into inlet chamber 1, and carry out acceleration and moderating process as described in step 2.Work as reagent disc
13 when slowing down, and under the action of compressible medium expands in discharge chambe 3, liquid can be discharged discharge chambe, due to second at this time
Body channel 5 is blocked by fluid column, so liquid can only be flowed out by first fluid channel 4, to be transported to the first collecting chamber 7
It is interior, to realize the effect of separating liquid.
Based on the principle of the above separating liquid, the device of the invention can also realize the function of microparticle processing.Specific step
Suddenly are as follows: Step 1: the initial speed of reagent disc 13 is 0, microparticle and liquid are added to together in inlet chamber 1, at this time inlet chamber 1
Interior liquid level is relative to innermost partially radially outer of the first, second syphon runner.Step 2: constantly changing reagent disc 13
Microparticle can be mixed with liquid, microparticle is made to be constantly in suspended state by velocity of rotation.(such as 60- at high speed
90Hz preferably uses 75Hz), partial suspended liquid is fed in discharge chambe 3.Centrifugal force is also larger at this time, inlet chamber 1 and pressure
The microparticle in suspension in contracting room 3 can be deposited to inlet chamber 1 and the most radially outer position of discharge chambe 3, and discharge chambe 3 compares
Inlet chamber 1 is much smaller, and most of microparticle is still located in inlet chamber 1, compresses indoor air at this time and is compressed.
Then the revolving speed of reagent disc 13 (such as with 10-20Hz/s, preferably 15Hz/s progress reduction of speed) is quickly reduced to 25-
45Hz, preferably 35Hz, compressed media expansion in discharge chambe 3, extrudes the liquid one in discharge chambe 3 at this time, extrudes
Liquid one enter first runner 2, the first syphon runner 4 and the second syphon runner 5, until liquid one passes through the second syphon runner
5 most radial inner positions, then utilize siphon principle, and liquid one is flowed into the second collecting chamber 6 by the second syphon runner 5
Interior, the volume of the second collecting chamber 6 is larger, can fully flow into from the liquid one being added in inlet chamber 1 into the second collecting chamber 6.?
Under the revolving speed, positioned at the microparticle of inlet chamber 1 and discharge chambe 3 still in precipitated form, due to microparticle and inlet chamber 1 and compression
The effect of 3 inner wall frictional force of room, microparticle will not be taken away by liquid one, thereby realize the separation of liquid one and microparticle.
At this point, liquid one has certain liquid level in the second collecting chamber 6, according to U-tube principle, in the second syphon runner 5
Bottom also can some fluid column, the height of the fluid column is identical as the liquid level in the second collecting chamber 6, thus by the second rainbow
Runner 5 is inhaled to block.
Step 3: adding liquid two into inlet chamber 1, the liquid level of liquid two is more innermost than the second syphon runner 5
It is partially radially outer.In the case where constantly quickly changing velocity of rotation, the microparticle of precipitating can be resuspended in liquid
In, it, can also be with external magnetic field come the suspension of auxiliary particle if microparticle band is magnetic.It repeats to accelerate described in step 2
And moderating process.When reagent disc 13 slows down, under the action of compressible medium expands in discharge chambe 3, liquid two can be discharged
Discharge chambe, since second fluid channel 5 is blocked by fluid column at this time, so liquid can only be flowed out by first fluid channel 4, thus
It is transported in the first collecting chamber 7, microparticle is still deposited in inlet chamber and discharge chambe, so as to realize microparticle with two kinds
Unused liquid is rinsed, and two different liquid are collected respectively, to meet the requirement of certain tests.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to previous embodiment
Documented technical solution is modified or equivalent replacement of some of the technical features；And these are modified or replace
It changes, the spirit and scope for technical solution of the embodiment of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of liquid delivery module based on centrifugal force, it is characterised in that it includes inlet chamber (1), is connected with inlet chamber (1)
It is common to the discharge chambe (3) for accepting the liquid from inlet chamber (1) through centrifugation discharge, first that one end is connected with discharge chambe (3)
Syphon runner (4) and the second syphon runner (5), the first collecting chamber (7) being connected with the first syphon runner (4) other end and
The second collecting chamber (6) being connected with the second syphon runner (5) other end, second syphon runner (5) is relative to the first rainbow
The position for inhaling runner (4) is radially outer, and the link positions of second syphon runner (5) and the second collecting chamber (6) is relative to the
Two collecting chambers (6) are radially outer close to the side of axis of rotation, and the first syphon runner (4) and axis of rotation are apart from nearest position
It is radially inner relative to the liquid level in inlet chamber (1).
2. a kind of liquid delivery module based on centrifugal force according to claim 1, it is characterised in that on inlet chamber (1)
It is provided with inlet (9) and first row port (8).
3. a kind of liquid delivery module based on centrifugal force according to claim 1 or 2, it is characterised in that described first
Second exhaust port (10) are provided on collecting chamber (7).
4. a kind of liquid delivery module based on centrifugal force according to claim 1 or 2, it is characterised in that described second
Third exhaust outlet (12) are provided on collecting chamber (6).
5. a kind of liquid delivery module based on centrifugal force according to claim 1, it is characterised in that the discharge chambe (3)
Position it is radially outer relative to inlet chamber (1).
6. a kind of liquid delivery module based on centrifugal force according to claim 1, it is characterised in that first siphon
Runner (4) and the second syphon runner (5) are inverted U shape.
7. a kind of liquid delivery module based on centrifugal force according to claim 1, it is characterised in that described second collects
In I-shaped, second syphon runner (5) is connected with the outboard chambers of the second collecting chamber (6) for room (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910290724.7A CN109939754A (en) | 2019-04-11 | 2019-04-11 | A kind of liquid delivery module based on centrifugal force |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910290724.7A CN109939754A (en) | 2019-04-11 | 2019-04-11 | A kind of liquid delivery module based on centrifugal force |
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| Publication Number | Publication Date |
|---|---|
| CN109939754A true CN109939754A (en) | 2019-06-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910290724.7A Pending CN109939754A (en) | 2019-04-11 | 2019-04-11 | A kind of liquid delivery module based on centrifugal force |
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| Country | Link |
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| CN (1) | CN109939754A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021121149A1 (en) * | 2019-12-19 | 2021-06-24 | 石家庄禾柏生物技术股份有限公司 | Whole blood separation structure |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4421503A (en) * | 1981-07-09 | 1983-12-20 | Haemonetics Corporation | Fluid processing centrifuge and apparatus thereof |
| DE102013203293A1 (en) * | 2013-02-27 | 2014-08-28 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidic device i.e. centrifugal disk, for e.g. automated bacteria-DNA-extraction from blood in laboratory, has outlet channels designed such that fluid is conducted via channel during expansion of compressed gas with expansion rate |
| DE102013215002B3 (en) * | 2013-07-31 | 2014-11-06 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Apparatus and method for moving liquid in a centrifugal system using vacuum |
| WO2015040149A1 (en) * | 2013-09-20 | 2015-03-26 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Device and method which make conclusions about the viscosity of a sample possible |
| CN210115075U (en) * | 2019-04-11 | 2020-02-28 | 石家庄禾柏生物技术股份有限公司 | Liquid conveying module based on centrifugal force |
-
2019
- 2019-04-11 CN CN201910290724.7A patent/CN109939754A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4421503A (en) * | 1981-07-09 | 1983-12-20 | Haemonetics Corporation | Fluid processing centrifuge and apparatus thereof |
| DE102013203293A1 (en) * | 2013-02-27 | 2014-08-28 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidic device i.e. centrifugal disk, for e.g. automated bacteria-DNA-extraction from blood in laboratory, has outlet channels designed such that fluid is conducted via channel during expansion of compressed gas with expansion rate |
| DE102013203293B4 (en) * | 2013-02-27 | 2016-01-21 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Apparatus and method for conducting a liquid through a first or second outlet channel |
| DE102013215002B3 (en) * | 2013-07-31 | 2014-11-06 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Apparatus and method for moving liquid in a centrifugal system using vacuum |
| WO2015040149A1 (en) * | 2013-09-20 | 2015-03-26 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Device and method which make conclusions about the viscosity of a sample possible |
| CN210115075U (en) * | 2019-04-11 | 2020-02-28 | 石家庄禾柏生物技术股份有限公司 | Liquid conveying module based on centrifugal force |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021121149A1 (en) * | 2019-12-19 | 2021-06-24 | 石家庄禾柏生物技术股份有限公司 | Whole blood separation structure |
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