CN109939368A - High-strength focus supersonic therapeutic system, method and device under guided by magnetic resonance - Google Patents
High-strength focus supersonic therapeutic system, method and device under guided by magnetic resonance Download PDFInfo
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- CN109939368A CN109939368A CN201711387743.9A CN201711387743A CN109939368A CN 109939368 A CN109939368 A CN 109939368A CN 201711387743 A CN201711387743 A CN 201711387743A CN 109939368 A CN109939368 A CN 109939368A
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Abstract
The present invention is applicable in mr imaging technique field, provide high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, method and device, the system includes: device mask cover, external power supply power interface, power-supply filter, power supply apparatus, signal generator, power amplifier and ultrasonic transducer, the present invention is shielded the electromagnetic wave of the internal components of the treatment system by device mask cover, the power supply line of external power supply is generated by power-supply filter, specified frequency is filtered out, when so that the system carrying out high-strength focusing ultrasonic therapy under guided by magnetic resonance, it restrained effectively high-strength focus supersonic therapeutic system interference caused by magnetic resonance imaging environment, to improve the clarity of magnetic resonance imaging, and then improve the effect of ultrasonic therapy.
Description
Technical field
The invention belongs to high intensity focused ultrasounds under mr imaging technique field more particularly to a kind of guided by magnetic resonance to control
Treatment system, method and device.
Background technique
High intensity focused ultrasound (High Intensity Focused Ultrasound, be abbreviated as HIFU) is in recent years
A kind of effective non-invasive therapy technology of the treatment tumour of rise, HIFU utilize the penetrability of ultrasonic wave, focusing, will be high-strength super
Sound focusing makes focus area in the short time to body tumor tissue under the mechanical effect of ultrasound, fuel factor and cavitation effect
Inner focusing very high heat causes protein denaturation downright bad, so that tumour cell is killed, currently with HIFU ablated tumor in clinic
On wide good, malignant tumour applied to the organs such as prostate, uterus, liver, mammary gland.
There are three types of the HIFU types of focusing: single array element self-focusing, sound lens focusing and phased array focus.Phased array is high-intensitive
It focuses ultrasonic (Phased High Intensity Focused Ultrasound, be abbreviated as PHIFU) and utilizes phased array radar battle array
Column principle generates single focus or multifocal sound field pattern, and then form required shape by adjusting the amplitude and phase of each array element
The focal regions of shape, size complete the conformal heating of orientation of target target tissue, realize ultrasonic focusing and scanning in three-dimensional space, from
Under the premise of without Mechanical Moving energy converter, realize that the three-dimensional of ultrasound focus is mobile.List element transducer HIFU relatively and
Acoustic lens energy converter HIFU, PHIFU can be formed different with the more flexible type of focusing according to specific treatment region
Focal intensities and distribution pattern form single focus or multifocal, and beam path control is more flexible, and acoustic beam is avoided to pass through bone etc.
Barrier makes normal tissue from damage, to greatly improve the ablation efficiency of tumour.
During PHIFU treats tumour, imaging monitoring is essential, and the most monitoring means of application are super at present
Sound, it is economical convenient, can reflect the image feature of target area in real time, therapeutic effect is judged by the change of image grayscale, but
There is many limitations for it, if picture quality is poor, cannot non-invasively reflect the temperature change in tissue in real time, be easy to cause
The safety issues such as the damage of normal tissue.
With the continuous development of magnetic resonance imaging (MRI) technology, mri guided PHIFU is clinically obtained at present
The characteristics of extensive use, magnetic resonance imaging utilizes nuclear spin campaign, generates letter in externally-applied magnetic field after RF pulse-to-pulse impulse
Number, signal is detected with detector, substance internal structure is obtained by computer disposal, is imaged in human body using proton, is obtained
Inside of human body institutional framework is one kind of tomographic imaging, to soft tissue resolution height, to the "dead" damage of human body.Magnetic resonance
Be imaged on guidance PHIFU treatment in, not only can clearly differentiate with positioning tumor tissue, can also accurately measure and control in real time
The temperature change for the treatment of process target area tissue, so that the accurate safe treatment for PHIFU provides effective monitoring means.
Since magnetic resonance imaging is very strict to environmental requirement, and magnetic resonance imaging and phased array high intensity focused ultrasound are controlled
Treatment carries out simultaneously, and phased array high intensity focused ultrasound system is placed in magnetic resonance environment, therefore phased array is high
Strong-focusing ultrasound can interfere magnetic resonance imaging, cause the unsharp problem of magnetic resonance imaging.
Summary of the invention
The purpose of the present invention is to provide high-strength focus supersonic therapeutic system, method and dresses under a kind of guided by magnetic resonance
It sets, it is intended to solve under guided by magnetic resonance during high-strength focusing ultrasonic therapy, the unsharp problem of magnetic resonance imaging.
On the one hand, the present invention provides high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, the system packets
It includes:
Device mask cover, the device mask cover ground connection, for shielding inside the high-strength focus supersonic therapeutic system
The electromagnetic wave that component generates;
The external power supply power interface connecting outside the device mask cover and with the device mask cover, for giving
The internal components provide power input;
Power-supply filter in the device mask cover, being connect with the external power supply power interface;
Power supply apparatus in the device mask cover, being connect with the power-supply filter;
Signal generator in the device mask cover, being connect with the power supply apparatus;
Power amplification in the device mask cover, being connect with the power supply apparatus and the signal generator
Device;And
Ultrasonic transducer, the pumping signal for exporting the power amplifier are converted into ultrasonic wave, with to patient into
Row ultrasonic therapy.
On the other hand, the present invention provides a kind for the treatment of method of above-mentioned treatment system, the method includes the following steps:
Under receiving to the tissue progress guided by magnetic resonance of user when the treatment request of high intensity focused ultrasound,
It controls the signal generator and corresponding phase delay signal is generated according to pre-set driving frequency;
It controls the power amplifier to amplify the phase delay signal of the generation, passes through the power amplifier
Output and the consistent pumping signal of pre-set phase;
The ultrasonic transducer is controlled to be generated according to the pumping signal for controlling tissue progress ultrasound
The ultrasonic wave for the treatment of.
On the other hand, the present invention provides a kind of therapeutic device of above-mentioned treatment system, described device includes:
Postpones signal generates unit, for high-intensitive under receiving to the tissue progress guided by magnetic resonance of user
When focusing the treatment request of ultrasound, controls the signal generator and prolonged according to the corresponding phase of pre-set driving frequency generation
Slow signal;
Pumping signal output unit puts the phase delay signal of the generation for controlling the power amplifier
Greatly, pass through power amplifier output and the consistent pumping signal of pre-set phase;And
Ultrasonic wave generator unit, for control the ultrasonic transducer according to the pumping signal generate for it is described to
Treat the ultrasonic wave that tissue carries out ultrasonic therapy.
The present invention provides high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, which includes device mask
Cover, outside device mask cover and connect with device mask cover external power supply power interface, in device mask cover
And connect with external power supply power interface power-supply filter, in device mask cover and the electricity that is connect with power-supply filter
Source device, in device mask cover and connect with power supply apparatus signal generator, in device mask cover and with
The power amplifier and ultrasonic transducer that power supply apparatus is connected with signal generator, the present invention is under using guided by magnetic resonance
When high-strength focus supersonic therapeutic system carries out ultrasonic therapy to patient, by device mask cover by the inside device of the treatment system
The electromagnetic wave of part is shielded, it is that the power supply line of external power supply is generated by power-supply filter, with preset harmonic frequency phase
Same frequency is filtered out, to reduce interference of the high intensity focused ultrasound to magnetic resonance imaging, improves guided by magnetic resonance
The clarity of magnetic resonance imaging in lower high-strength focusing ultrasonic therapy, and then improve the effect of ultrasonic therapy.
Detailed description of the invention
Fig. 1 is the structural representation of high-strength focus supersonic therapeutic system under the guided by magnetic resonance that the embodiment of the present invention one provides
Figure;
Fig. 2 is the preferred structure of high-strength focus supersonic therapeutic system under the guided by magnetic resonance that the embodiment of the present invention one provides
Schematic diagram;
Fig. 3 is the implementation process of high-strength focusing ultrasonic therapy method under guided by magnetic resonance provided by Embodiment 2 of the present invention
Figure;And
Fig. 4 is the structural representation of high intensity focused ultrasound therapy device under the guided by magnetic resonance that the embodiment of the present invention three provides
Figure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Specific implementation of the invention is described in detail below in conjunction with specific embodiment:
Embodiment one:
Fig. 1 shows the knot of high-strength focus supersonic therapeutic system under the guided by magnetic resonance that the embodiment of the present invention one provides
Structure, for ease of description, only parts related to embodiments of the present invention are shown.
The embodiment of the invention provides high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, which includes setting
Standby shielding case 11, external power supply power interface 12, power-supply filter 13, power supply apparatus 14, signal generator 15, power amplifier
16 and ultrasonic transducer 17, in which:
Device mask cover 11 is grounded, for shielding the electromagnetic wave of high-strength focus supersonic therapeutic system internal part generation.
External power supply power interface 12 is located at 11 outside of device mask cover and connect with device mask cover 11, for high-strength focused super
Sound treatment system internal components provide power input.Power-supply filter 13 is located in device mask cover 11, and electric with external power supply
Source interface 12 is connected, and the assigned frequency for generating power supply line filters out.In device mask cover 11 and power supply
The power supply apparatus 14 that filter 13 connects, for being powered for high-strength focus supersonic therapeutic system internal components.Signal hair
Raw device 15 is located in device mask cover 11, and is connected with power supply apparatus 14, for generating the phase delay signal of assigned frequency.
Power amplifier 16 is located in device mask cover 11, and is connected with power supply apparatus 14 and signal generator 15, for that will believe
The phase delay signal that number generator 15 generates amplifies.Ultrasonic transducer 17 is used for the excitation for exporting power amplifier 16
Signal is converted into ultrasonic wave, to carry out ultrasonic therapy to patient.
Preferably, the shell of power-supply filter 13 is fixedly connected with device mask cover 11, to improve power-supply filter
13 filtering performance.
Optionally, power-supply filter 13 can be set outside device mask cover 11, and the shell of power-supply filter 13 with
Device mask cover 11 is fixedly connected with (for example, passing through welded connecting), in order to the heat dissipation of power-supply filter.
Preferably, signal generator 15 is phased array signal generator, super not needing Mechanical Moving by phase control principle
In the case where sonic transducer, realizes and moved in the three-dimensional space of focus in a certain range, so as to avoid due to Mechanical Moving
It is interfered to caused by magnetic resonance imaging.
As shown in Figure 2, it is preferable that the treatment system further includes adaptation 18, the input terminal and equipment screen of the adaptation 18
The power amplifier 16 covered in cover 11 connects, and the output end of adaptation 18 is connect with ultrasonic transducer 17, thus to device mask
The harmonic interference signals that internal components in cover 11 generate are inhibited, and the output power of transmission line is improved.
Preferably, the transmission line that adaptation 18 is connect with power amplifier 16 and ultrasonic transducer 17 is coaxial cable
Line, the coaxial wire have very strong screening ability, to effectively be shielded to the electromagnetic interference generated in signal transmission
It covers.
The present invention provides high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, which includes device mask
Cover, outside device mask cover and connect with device mask cover external power supply power interface, in device mask cover
And connect with external power supply power interface power-supply filter, in device mask cover and the electricity that is connect with power-supply filter
Source device, in device mask cover and connect with power supply apparatus signal generator, in device mask cover and with
The power amplifier and ultrasonic transducer that power supply apparatus is connected with signal generator, the present invention should by device mask cover
The electromagnetic wave of the internal components for the treatment of system is shielded, being generated the power supply line of external power supply by power-supply filter, refer to
Fixed frequency is filtered out, and when so that the system carrying out high-strength focusing ultrasonic therapy under guided by magnetic resonance, is effectively inhibited
High-strength focus supersonic therapeutic system is interfered caused by magnetic resonance imaging environment, improves the clarity of magnetic resonance imaging,
And then improve the effect of ultrasonic therapy.
Embodiment two:
Fig. 3 shows the realization of high-strength focusing ultrasonic therapy method under guided by magnetic resonance provided by Embodiment 2 of the present invention
Process, for ease of description, only parts related to embodiments of the present invention are shown, and details are as follows:
In step S301, high intensity focused ultrasound under guided by magnetic resonance is carried out when receiving the tissue to user
Treatment request when, control signal generator generates corresponding phase delay signal according to pre-set driving frequency.
High-strength focus supersonic therapeutic system under the guided by magnetic resonance embodiment one of the embodiment of the present invention, with right
The tissue of user carries out ultrasonic therapy.Preferably, it is receiving under the tissue progress guided by magnetic resonance of user
Before the treatment request of high intensity focused ultrasound, external power supply is accessed by external power supply power interface, for high intensity
Focusing ultrasonic therapeutic system internal part is powered, that control power-supply filter generates the power supply line of external power supply and pre-
If the identical frequency of harmonic frequency filtered out, thus reduce because electric current transmission caused by harmonic wave interference.
It is further preferred that the signal generator of the embodiment of the present invention is phased array signal generator, it can produce a variety of phases
Position delay, the adjustable phased signal of frequency, to improve the focusing performance of the treatment system.
In step s 302, control power amplifier amplifies the phase delay signal of generation, passes through power amplification
Device output and the consistent pumping signal of pre-set phase.
In embodiments of the present invention, power amplifier is substantially a LC resonance circuit, and power amplifier sends out signal
The phase delay signal that raw device generates is amplified by resonance, is swashed by the way that power amplifier output and pre-set phase are consistent
Encourage signal, it is preferable that the phase delay signal amplified by power amplifier is transmitted to adaptation, by adaptation output with
The pre-set consistent pumping signal of phase, so that the impedance of ultrasonic transducer matches with power amplifier impedance,
Improve the output power of transmission line.
In step S303, control ultrasonic transducer is generated according to pumping signal and is controlled for carrying out ultrasound to tissue
The ultrasonic wave for the treatment of.
In embodiments of the present invention, control ultrasonic transducer is generated according to pumping signal for surpassing to tissue
The ultrasonic wave of sound treatment, it is preferable that ultrasonic transducer is phased array high intensity focused ultrasound energy converter, which can be not necessarily to
Realize that the three-dimensional of focus in larger range is mobile under Mechanical Moving energy converter, while the energy converter can form multifocal, to mention
The high therapeutic efficiency of the ultrasonic therapy.
In embodiments of the present invention, high-strength focused under receiving to the tissue progress guided by magnetic resonance of user
When the treatment request of ultrasound, control signal generator according to pre-set driving frequency generate corresponding phase delay signal it
Before, firstly, frequency that control power-supply filter generates the power supply line of external power supply, identical with preset harmonic frequency carries out
It filters out, so that harmonic wave interference caused by reducing because of electric current transmission controls power amplifier for the phase delay signal of generation later
It amplifies, then amplified signal is transmitted to adaptation, so that the impedance of ultrasonic transducer and power amplifier hinder
It is anti-to match, the output power of transmission line is improved, later, passes through adaptation output and the consistent excitation of pre-set phase
Signal, finally, control ultrasonic transducer generates the ultrasonic wave for carrying out ultrasonic therapy to tissue according to pumping signal,
When method through the embodiment of the present invention carries out ultrasonic therapy, to restrained effectively high-strength focus supersonic therapeutic system pair
It is interfered caused by magnetic resonance imaging environment, improves the clarity of magnetic resonance imaging, and then improve the effect of ultrasonic therapy.
Embodiment three:
Fig. 4 shows the knot of high intensity focused ultrasound therapy device under the guided by magnetic resonance that the embodiment of the present invention three provides
Structure, treatment system of the therapeutic device suitable for embodiment one illustrate only and phase of the embodiment of the present invention for ease of description
The part of pass, including:
Postpones signal generates unit 41, for high-strength under receiving to the tissue progress guided by magnetic resonance of user
When degree focuses the treatment request of ultrasound, control signal generator generates corresponding phase delay according to pre-set driving frequency
Signal;
Pumping signal output unit 42 amplifies the phase delay signal of generation for controlling power amplifier, leads to
The output of overpower amplifier and the consistent pumping signal of pre-set phase;And
Ultrasonic wave generator unit 43, for control ultrasonic transducer according to pumping signal generate for tissue into
The ultrasonic wave of row ultrasonic therapy.
In embodiments of the present invention, each unit of high intensity focused ultrasound therapy device can be by corresponding under guided by magnetic resonance
Hardware or software unit realize that each unit can be independent soft and hardware unit, also can integrate as a soft and hardware unit,
Herein not to limit the present invention, the specific embodiment of each unit can refer to the description of embodiment two, and details are not described herein.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. high-strength focus supersonic therapeutic system under a kind of guided by magnetic resonance, which is characterized in that the system comprises:
Device mask cover, the device mask cover ground connection, for shielding the high-strength focus supersonic therapeutic system internal part
The electromagnetic wave of generation;
The external power supply power interface connecting outside the device mask cover and with the device mask cover, for described
Internal components provide power input;
Power-supply filter in the device mask cover, being connect with the external power supply power interface;
Power supply apparatus in the device mask cover, being connect with the power-supply filter;
Signal generator in the device mask cover, being connect with the power supply apparatus;
Power amplifier in the device mask cover, being connect with the power supply apparatus and the signal generator;
And
Ultrasonic transducer, the pumping signal for exporting the power amplifier are converted into ultrasonic wave, to surpass to patient
Sound treatment.
2. treatment system as described in claim 1, which is characterized in that the processing system further includes adaptation, the adaptation
Input terminal connect with the power amplifier in the device mask cover, output end is connect with the ultrasonic transducer.
3. treatment system as claimed in claim 2, which is characterized in that the adaptation and the power amplifier and described super
The transmission line of sonic transducer connection is coaxial wire.
4. treatment system as described in claim 1, which is characterized in that the shell of the power-supply filter and the device mask cover
It is fixedly connected.
5. treatment system as described in claim 1, which is characterized in that the signal generator is phased array signal generator.
6. high-strength focusing ultrasonic therapy side under a kind of guided by magnetic resonance based on any treatment system of claim 1-5
Method, which is characterized in that the described method comprises the following steps:
Under receiving to the tissue progress guided by magnetic resonance of user when the treatment request of high intensity focused ultrasound, control
The signal generator generates corresponding phase delay signal according to pre-set driving frequency;
It controls the power amplifier to amplify the phase delay signal of the generation, be exported by the power amplifier
With the consistent pumping signal of pre-set phase;
The ultrasonic transducer is controlled to be generated according to the pumping signal for carrying out ultrasonic therapy to the tissue
Ultrasonic wave.
7. treatment method as claimed in claim 6, which is characterized in that total to the tissue progress magnetic of user when receiving
When vibration guides the treatment request of lower high intensity focused ultrasound, controls the signal generator and produced according to pre-set driving frequency
Before the step of raw corresponding phase delay signal, comprising:
By external power supply power interface access external power supply, with for high-strength focus supersonic therapeutic system internal part into
Row power supply;
Control frequency that the power-supply filter generates the power supply line of the external power supply, identical with preset harmonic frequency
It is filtered out.
8. treatment method as claimed in claim 6, which is characterized in that control the power amplifier for the phase of the generation
The step of postpones signal amplifies, pumping signal consistent with pre-set phase by power amplifier output,
Include:
The phase delay signal amplified by the power amplifier is transmitted to the adaptation, is exported by the adaptation
With the consistent pumping signal of pre-set phase.
9. one kind is based on any processing system therapeutic device of claim 1-5, which is characterized in that described device includes:
Postpones signal generates unit, for high-strength focused under receiving to the tissue progress guided by magnetic resonance of user
When the treatment request of ultrasound, the signal generator is controlled according to pre-set driving frequency and generates corresponding phase delay letter
Number;
Pumping signal output unit amplifies the phase delay signal of the generation for controlling the power amplifier,
Pass through power amplifier output and the consistent pumping signal of pre-set phase;And
Ultrasonic wave generator unit is generated according to the pumping signal for described to be treated for controlling the ultrasonic transducer
Tissue carries out the ultrasonic wave of ultrasonic therapy.
10. therapeutic device as claimed in claim 9, which is characterized in that the pumping signal output unit includes:
Signal exports subelement, for the phase delay signal amplified by the power amplifier to be transmitted to the matching
Device passes through adaptation output and the consistent pumping signal of pre-set phase.
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