CN109928062A - A kind of sheath system and its packaging method - Google Patents
A kind of sheath system and its packaging method Download PDFInfo
- Publication number
- CN109928062A CN109928062A CN201910018430.9A CN201910018430A CN109928062A CN 109928062 A CN109928062 A CN 109928062A CN 201910018430 A CN201910018430 A CN 201910018430A CN 109928062 A CN109928062 A CN 109928062A
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- Prior art keywords
- sheath
- container
- lantern ring
- reagent
- item
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
- B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
- B65D75/368—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments the compartments being interconnected, e.g. by small channels
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- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Packages (AREA)
Abstract
The invention discloses a kind of sheath systems, and including the sheath and container rolled, the sheath rolled is set in container, and the sheath rolled includes lantern ring, the women side and male side that are mutually isolated；The invention also discloses a kind of packaging methods of sheath system, comprising the following steps: by reagent " asymmetry " addition in sheath and/or container；The male side and women side of sheath is isolated；And sheath is sealed in container；After sealing, lantern ring and/or the mantle receiving for the sheath rolled have pressure.The reagent of " asymmetry " addition in sheath system, mutual migration during carrying and storage, between the sheath two sides space rolled can be greatly decreased before sealing in sheath system provided by the invention；After storage for a long period, the reagent of sheath two sides obviously keeps " asymmetry " state before sealing, meets the different demands of women and male.
Description
Technical field
The present invention relates to sheath field, especially a kind of sheath system and its packaging method, in particular to one kind can
With the reagent of " asymmetry " addition in sheath system before reduction sealing during carrying and storage, in the sheath rolled
Between women side and male side (unless specified, any side is known as " side ", and the two is collectively referred to as " two sides ") space mutually
The mutually sheath system and its packaging method of migration.Sheath system provided by the invention is by carrying and long-time storage
Afterwards, good isolation is kept between the women side and male side of sheath, the reagent of sheath two sides obviously keeps sealing
Preceding " asymmetry " state can meet " asymmetry " demand of women and male to function respectively.
Background technique
Sheath is widely used in human sexuality, and conventional func includes contraception, prevents HIV (human immune deficiency
Virus) and various sexually transmitted diseases original cross-infection.The sheath (as shown in Figure 1) rolled include mantle closed end 1, with
And the lantern ring 2 of the curling of part mantle and formation, wherein the mantle of closed end is divided into women side 3 and (contacts with cavity or vagina
Mantle on the outside of) and male side 4 (contacted with male penis mantle inside).Lantern ring 2 when women side is placed upward is divided into
Upside 5, downside 6, inside 7 and outside 8.Wherein the interior perimeter of lantern ring refer to be formed by the inside of lantern ring closed curve length,
The internal diameter of lantern ring is that finger sleeve ring is positive diameter corresponding to perimeter in bowlder；Wherein the outer perimeter of lantern ring is institute's shape on the outside of finger sleeve ring
At the length of closed curve, the outer diameter of lantern ring be that finger sleeve ring is positive diameter corresponding to bowlder outer perimeter；Wherein lantern ring is straight
Diameter is the diameter in the cross section of lantern ring.
It when using sheath in sexual life, wears for convenience, facilitate sexual behaviour implementation, prevention is infected, it is vigorous to improve
Playing various purposes, women and the males such as function, prolonged erection time, enhancing sexual desire has different demands to these functions, from
And they are also different for the demand of the amount and type of the reagent of women side and male side when using sheath, we claim
Be " asymmetry " function.
These reagents with certain function can with individually pack human body lubricants or medicinal forms (suppository, gel,
Tablet etc.) etc. forms give.But use for convenience, directly addition is clearly more in sheath or condom package system
Good selection.
The adding method of sheath lubricant at present, it is a certain amount of to be added in the side or packaging material for rolling sheath
With the lubricant of type, then it is sealed in packaging material.Also there is the method for other addition reagents, for example anti-premature ejaculation is tried
Agent, then directly with liquid or semisolid addition in male side.In existing packing technique, in entire sealed package only one
The space of connection, sheath male side and women side are not mutually isolated.As a result, during transporting and storing, add in female
The reagent of property side or male side can be migrated gradually to the other side, and this migration can be close to 50% after several weeks, i.e. the reagent kind of two sides
Class and amount reach unanimity (i.e. " symmetrical ").As a result, before no matter sealing the lubricant of the women side and male side of sheath just
Beginning state is how " asymmetry ", when being stored in several weeks arrival consumer's hand, the reagent of the two sides of sheath has tended to
" symmetrical " is unable to satisfy " asymmetry " demand of male and female to the function (such as lubrication) of sheath two sides.
In order to overcome the above technical problems, providing has the function of obviously " asymmetry " and effect when a kind of consumer uses
Sheath, those skilled in the art have done various trials:
European Union patent EP1003448B1 discloses a kind of design, sheath open end male side with viscous layer,
Has non-adhesive layer in the women side of open end；Viscous layer makes sheath better adhere to penis and avoids pine sliding, inviscid
Layer then prevents adhesive component to be attached to women side.But adhesive component will lead to user's discomfort, and mantle is made to be difficult to well roll up
It rises, and increases the risk for influencing set film quality.
United States Patent (USP) US4930522A discloses a kind of device that can be used as sheath, pastes between two elastomeric layers
Micro-capsule with Study on Anti-infection Bioactivities；In use, micro-capsule ruptures under frictional force effect and discharges active material.But
Unlubricated dose of male side will lead to that wearing is difficult, and rolling the formed pressure of sheath, the external force in transport process etc. may
Micro-capsule wall is set to be pressurized and cause to discharge active material in advance.
Chinese patent CN104921862B discloses a kind of sheath that inner surface moderately lubricates, it is intended to can prevent loose cunning
And it is convenient to wear, the satisfaction of user is promoted, still, sheath needs are repeatedly coated in mantle the inner surface and the outer surface
Lubricant, efficiency is lower, uses inconvenient.Reagent can be reduced therefore, it is necessary to one kind to move mutually in sheath two sides
The sheath system of shifting, when specifically showing even across being transported for a long time with after storage, taking out and using sheath, contraception
Set is able to maintain " asymmetry " function of women side and male side.
Summary of the invention
Based on above-mentioned technical problem, in order to overcome the above-mentioned shortcoming of the prior art, the present invention provides a kind of sheath
System and its packaging method, sheath system provided by the invention can reduce " asymmetry " addition in the preceding sheath system of sealing
Reagent, mutual migration during carrying and storage, between the women side and male side space for the sheath rolled；This
Kind of sheath system when being taken out after carrying and long-time storage and using sheath, the women side for the sheath rolled and
Keep good isolation between male side, the women side of sheath and the reagent of male side obviously keep before sealing " no
Symmetrically " state can meet " asymmetry " demand of women and male to certain function respectively.This sheath system user
Just.
To achieve the above object, the technical scheme adopted by the invention is as follows:
A kind of sheath system, including the sheath and container rolled, the sheath rolled is set to the container
Interior, the sheath rolled includes the women side and male side of lantern ring, the mantle being mutually isolated.Space is divided in the container
At least two spaces being mutually isolated are cut into, the male side and women side are respectively at different be isolated in space.As a result,
Reagent can be reduced in the mutual migration of women side and male side, by transporting and storing for a long time, taken out from the container
And when using sheath, sheath there remains " asymmetry " reagent and its function of women side and male side.It should illustrate
, it is added reagent on described in the technical program in women side or male side, it is such as non-specifically specified, it refers to making an addition to this
Space where side；Described " asymmetry " addition, it is such as non-specifically specified, it refers in space where the women side being mutually isolated
It is different with the amount and/or type of the reagent of space addition where male side.
" connection " of sheath and container in the technical program, be finger sleeve ring and/or mantle at least one side or the multi-lateral with
Some component (such as annular projection, annular groove, hardboard etc.) in container in certain or many places or the container or container
It is in close contact, and then realizes the isolation to the women side and male side of sheath, to reduce reagent between sheath two sides
Migration.
It " is fixedly connected " described in the technical program, refers to columnar projections, annular groove and/or the hardboard, with institute
Stating container is an entirety.
" columnar projections " described in the technical program are the solid surrounded by least one curved surface and/or plane, different
The outer profile and its size of horizontal cross-section can change.
Preferably, the lantern ring and/or mantle are connect with the container, to form the women side for the sheath being mutually isolated
With male side.Can be added respectively in sheath or container suitable pigment, essence, peppermint, insoluble particulates or suspended matter,
The gain of heat or increasing cold material etc..
Preferably, it is added with reagent in the sheath rolled and/or container, reagent can be lubricant, AntiHIV1 RT activity
Reagent, anti-erectile dysfunction reagent, anti-premature ejaculation reagent, anti-infective agents, hemostasis agents, anti-epidermis mucosa injury reagent, sexual desire increase
One of strong reagent, enhanced sensitivity reagent, maintenance care agent are a variety of.It is molten that the lubricant can be soluble oil, oil
Property lubricant, water oil be formed by various emulsions (including emulsion, Submicron Emulsion, micro emulsion), gelling agent, soft capsule, suppository, solid
One of body preparation or multiple combinations；The lubricant can contain the polymer of different molecular weight, such as glucan, fiber
Element, natural gum, pectin or pectic substance, Bo Shamu, calcium polycarbophil, hyaluronic acid, protein, chitosan-containing extract, aloe mention
Take object, cell pyrolysis liquid, bio-safety oil matrix (such as silicone oil and its derivative, castor oil etc.), medicinal slow controlled-release material
Deng one of or it is a variety of.
Preferably, sheath of the invention contains the reagent of not same amount and/or type in women side and male side.Women side
Reagent amount be preferably 0.3-2.5ml, male side the amount of reagent be preferably 0-0.2ml.The pH of women side reagent is preferably
The pH of 3.8-5.8, male side reagent are preferably 6.0-8.0.
Preferably, the AntiHIV1 RT activity reagent refer to inside and outside have the intrusion of AntiHIV1 RT activity, reverse transcription, insertion, transcription, translation,
The reagent of assembling etc. can inactivate the reagent of HIV or the reagent of adsorbable HIV particle, including tenofovir, Zidovudine, take charge of it
Husband is fixed, deglycoside, Lamivudine, how Wella is flat, indinavir, efavirenz, Troyes reach, Du Lutewei, Kang Pulai, drawing
For draw Wei potassium, Rui Lawei, Wei Ruide, in accordance with the law Wei Enci, active carbon, resin, the macromolecular with multiple branched ends groups
And its one of derivative and/or salt, zinc salt, sulfonate etc. or multiple combinations.
Preferably, the anti-erectile dysfunction reagent refers to the external reagent for having and improving erectile dysfunction, including PDE
Inhibitor class drug (such as silaenafil, Tadalafei, Vardenafil, avanaphil, excellent that non-, meter Luo Nafei of ground), forefront
Parathyrine class (such as Alprostadil), extracts species (for example extracting from Chinese medicine, plant, animal tissue) and its derivative at yogimbine
And/or one of salt or multiple combinations.
Preferably, the anti-premature ejaculation reagent refers to anti-premature ejaculation or the active reagent of delay ejaculation, including benefit card
Cause, benzocainum, cloth help cacaine, benzocainum, Prozac, Paxil, Duloxetine, Dapoxetine hydrochloride, Sertraline, Ai Sixiang
Species (for example extracting from Chinese medicine, plant, animal tissue) and its one of derivative and/or salt or a variety of are extracted in phthalein Pulan
Combination.
Preferably, the anti-infective agents, refer to antibacterial (including bacterium, fungi, Chlamydia, mycoplasma, trichomonad,
Helminth, other virus such as HPV, CMV, HSV, hepatitis virus in addition to HIV etc.) or bacteriostatic activity reagent, including miaow
Health azoles, clotrimazole, butoconazole, Fenticonazole, econazole, metronidazole, Nifuratel, Isoconazole, Sertaconazole, terconazole, fluorine
Health azoles, voriconazole, Itraconazole, posaconazole, Chinese mugwort Saperconazole, Oxiconazole, sulconazole, andiconazole, Eberconazole, naphthalene
For fragrant, meter Ka Bo is net, Caspofungin, Nysfungin, amphotericin B, povidone iodine, ticonazole, clindamycin phosphate, nitre difficult to understand
Azoles, lactein, Ciprofloxacin, matrine, Ciclopirox Olamine, Policresulen, bifonazole, snake Huang, ginseng and astragalus yang warming, general sieve are purple
Alkene, chloramphenicol, polybenzobisoxazole Thailand, recombinant human interferon alpha 2, Chlorhexidine, Terbinafine and its one of derivative and/or salt or a variety of
Combination.
Preferably, the hemostasis agents refer to the reagent with local hemostasis effect, such as tranexamic acid, Yunnan Baiyao, stop
Blood meal etc..
Preferably, the container includes soft bag；Alternatively, the container is made of hard material；Alternatively, the container includes
The hard box body being made of hard material；Alternatively, the container includes hard box body and soft bag.Preferably, the container includes
Hard box body and lid.It can be sealed by conventional methods such as heating, pressurization, buckle, gluings between the hard box body and lid.
The packaging material that sheath of the invention is made can be used the packaging material of medical instrument, can be in given pressure
Little amplitude variation shape is in range to keep the hard packing material connecting with the sheath lantern ring and/or mantle rolled, for example moulds
The soft but hard skeleton composite wood in flitch, novel high polymer material plate, metal plate, high-intensitive cardboard, rubber slab, silica gel plate, part
Material etc.；It is also possible to the easily-deformable soft package material so as to the relatively uniform contact of sheath rolled, for example moulds
Expect film, composite plastic film, glassine paper, metal foil or piece and its composite membrane or by relative harder material through folding or other processing
And material substantially deformed etc. is not easy as described in the part holding for being easy to be distorted in the part of sealing and in addition.
Preferably, the slot for placing sheath is equipped in the rigid packet body, the diameter of the lantern ring is greater than the slot
Height.When lid is sealed with hard box body as a result, lantern ring and/or mantle will receive the women side for squeezing and then realizing sheath
Isolation between male side, with mutual migration of the reagent of reduction " asymmetry " addition between the sheath two sides rolled.
Preferably, the container includes soft bag and hard box body with multi-layer structure, and the sheath rolled is set to soft bag
Interior, the diameter of the lantern ring is greater than the spacing in each layer.
Preferably, columnar projections are equipped in the container, the set ring set is in the columnar projections.The set as a result,
Ring or the lantern ring and mantle are connect with the surface of the columnar projections, thus by between the women side and male side of sheath
Isolation, with mutual migration of the reagent of reduction " asymmetry " addition between the sheath two sides rolled.
Preferably, the side wall of the columnar projections is equipped with prominent at least one or invagination.It is highly preferred that the column is convex
The top sides risen are along at least one protrusion outwardly.It is highly preferred that the inner sidewall vertical plane of the annular groove is equipped with invagination,
The lantern ring is set to be more stably mounted in columnar projections.It is highly preferred that the side wall of the columnar projections is equipped at least one
Place's invagination, the invagination outer with the set ring diameter is away from being squeezed the lantern ring at the invagination equipped with a pillars
Tightly.Thus, it is possible to prevent the lantern ring from slipping from the columnar projections.
Preferably, the outer profile of the horizontal cross-section of the columnar projections is closed curve, polygon or by curve and straight
Line is linked to be close-shaped.It is highly preferred that the columnar projections are rotary body (including cylindrical body, round estrade, hemisphere etc.), column
One of body (including Elliptic Cylinder, prism, prismoid etc.) or multiple combinations.
Preferably, the centre of the columnar projections has sunk structure.Thus, it is possible in the valley add reagent and/or
Place the mantle of sheath.
Preferably, at least one handle is arranged at the bottom of the columnar projections, convenient for taking out sheath.
Preferably, the columnar projections are fixedly connected with the container.
Preferably, the outer perimeter of the columnar projections is greater than or equal to the interior perimeter of the lantern ring.
Preferably, the container includes circular groove structure, and the lantern ring is embedded in the annular groove.It is described as a result,
Annular groove is connect with the inner side and outer side of the lantern ring, thus by being isolated between the women side and male side of sheath, to subtract
Mutual migration of the reagent of few " asymmetry " addition between the sheath two sides rolled.
It should be noted that the diameter of lantern ring is the average value of the diameter in the cross section of lantern ring, measuring method is to take 20
Sheath uniformly chooses 10 points to every sheath lantern ring after sufficiently rolling and carries out contact measurements, these measured values
Average value is the diameter of lantern ring.
Preferably, the side wall of the annular groove is equipped with prominent at least one or invagination.It is highly preferred that the annular groove
Lateral wall be equipped at least one at towards groove protrusion.It is highly preferred that the one side wall of the annular groove is equipped at least one
Invagination is accordingly equipped with the protrusion of shape complementation in another side wall, makes the lantern ring at the invagination by jam-packed.By
This, can further avoid sheath and fall off from annular groove.
Preferably, the Internal periphery of the horizontal cross-section of the annular groove is closed curve, polygon or by curve and straight
Line is linked to be close-shaped.
Preferably, the inner wall of the annular groove upwardly extends to form a columnar projections, the centre of the columnar projections
Equipped with sunk structure.
Preferably, the annular groove is fixedly connected with the container.
Preferably, low ebb is extended into outward at the one of the annular groove；Thus, it is possible to be easily removed sheath.
It is highly preferred that the bottom of the low ebb is lower than the bottom of the annular groove.It is highly preferred that the low ebb is the low ebb on inclined-plane,
The volume of the low ebb can be reduced.It is highly preferred that the low ebb is the low ebb of shallow slot sample, by the bottom of the annular groove
Extend on the outside of to the annular groove, rope band or uncinus can be placed in the low ebb, by pullling rope band or uncinus
Take out sheath with can be convenient.
Preferably, the width of the annular groove is less than or equal to the diameter+1.5mm of the lantern ring.Since sheath is rolled up
The extensive difference of side size, mantle average thickness and caliper uniformity, between different sheaths, within same sheath,
The diameter for the sheath lantern ring rolled is inhomogenous in each point.Multi-site determination and statistical analysis of the present inventor through a large amount of samples, hair
The maximum fluctuation range of the existing set ring diameter is no more than 1.5mm.In addition, in process of production, ensuring the sheath set
Ring connect with the annular groove it is good under the premise of, in order to guarantee to pack the production efficiency of link, reduce lantern ring not well
It is embedded in the probability of the annular groove, it is necessary to which the width of the annular groove is set up into the diameter less than or equal to the lantern ring
+1.5mm。
Preferably, the outer wall of the annular groove and/or inner wall are arranged by multiple columnar projections and are formed, the multiple column
Gap is equipped between two adjacent columnar projections in shape protrusion.Preferably, the columnar projections be cylindrical body, Elliptic Cylinder,
One of prism, stage body, arc cylinder etc. or multiple combinations.Preferably multiple columnar projections annular arrays are inside and outside two
Layer, the lantern ring are arranged between the columnar projections of inside and outside two layers of annular array, to realize to the women side of sheath and male
Isolation between property side.It is highly preferred that the multiple columnar projections are fixedly connected with the container.
More preferably a kind of scheme is that the container is hard box body, and it is recessed that annular is fixedly connected in the rigid packet body
The bottom of slot structure, the annular groove is arc, and the inner wall of the annular groove upwardly extends to form a columnar projections, institute
The centre for stating columnar projections is equipped with sunk structure, and the side wall of the annular groove is equipped with prominent at least one, the annular groove
One at extend into inclined-plane low ebb outward, the bottom of the inclined-plane low ebb is lower than the bottom of the annular groove.
More preferably another scheme is that the container is hard box body, is fixedly connected with annular in the rigid packet body
The bottom of groove structure, the annular groove is arc, and the inner wall of the annular groove upwardly extends to form a columnar projections,
The centre of the columnar projections is equipped with sunk structure, and the side wall of the annular groove is equipped at least one and protrudes, and the annular is recessed
There is the low ebb of a shallow slot sample at the one of slot by bottom, the low ebb is extended to outward other than the annular groove, described
Rope band or uncinus can be placed in the low ebb of shallow slot sample.
Preferably, hardboard is equipped in the container, each face of the hardboard can be plane and/or curved surface respectively.It is described
The upside of hardboard and the sheath lantern ring, downside, inside, outside, mantle women side, at least side in mantle male side connect
It connects.After hardboard is connect with the lantern ring and/or mantle side as a result, may be implemented to the women side of sheath and male side it
Between isolation, with the mutual migration of the reagent between the sheath two sides rolled of reduction " asymmetry " addition.
Preferably, the hardboard has hollow structure, and the lantern ring is connect with the inside of the hardboard.
Preferably, the hardboard has the sunk structure that can accommodate reagent.
It is highly preferred that the hardboard is fixedly connected with the hard box body.
It is highly preferred that be placed in the hardboard for the sheath side rolled, and it is placed in the another of the sheath rolled
The container of side is fixedly connected.
Preferably, there is pressure between the lantern ring and/or mantle and the container；It is highly preferred that the pressure value is
0.196~98N；Most preferably, the pressure value is 0.490~49N.
Preferably, the air pressure inside the container is less than external container air pressure；It is highly preferred that the air pressure inside the container
0.002~0.095 megapascal (MPa) smaller than container external pressure；Most preferably, the air pressure inside the container is than external container gas
Press small 0.005~0.090 megapascal (MPa).The lantern ring and mantle receiving have above-mentioned pressure as a result,.
The present inventor has found through test of many times, when the pressure that the lantern ring and/or mantle are subject within the above range when, keep away
Be mutually isolated between the women side and male side of pregnant set, can effectively reduce reagent the women side of sheath and male side it
Between mutual migration, even across transporting and store for a long time, after taking out sheath, which is still able to maintain women side
With " asymmetry " of the reagent of male side.
The sheath is using in Heveatex, polyurethane, polyisoprene, butyl rubber, silicon rubber or graphene
It is one or more to be made.
It is described to keep away the present invention also provides a kind of packaging method of sheath system as another aspect of the present invention
Pregnant set system includes the sheath and container rolled, comprising the following steps:
By lubricant, AntiHIV1 RT activity reagent, anti-erectile dysfunction reagent, anti-premature ejaculation reagent, anti-infective agents, hemostasis agents, sexual desire
One of Contrast agent or a variety of additions are in the sheath and/or the container；
The women side and male side of the sheath is isolated；And
Sheath is sealed in container；
After sealing, the sheath lantern ring rolled and/or mantle receiving have pressure.
It should be noted that in some cases (such as to real between the male side for rolling sheath and women side
Go and be mutually isolated the diameter for being to rely on the lantern ring situation high greater than the slot of the hard box body), complete isolation sheath
Women side and male side the step of with sealing sheath the step of synchronously complete.
Preferably, in the isolation step, by between the lantern ring and/or mantle and the container to the sheath
Apply pressure, so that being mutually isolated between the women side and male side of the sheath；It is highly preferred that the sheath lantern ring
And/or the pressure that mantle is subject to is 0.196~98 newton；Most preferably, the pressure that the sheath lantern ring and/or mantle are subject to
For 0.490~49 newton.The present inventor has found through test of many times, when the pressure that lantern ring and/or mantle are subject within the above range
When, it is mutually isolated between the women side of the sheath and male side by making, reagent can be effectively reduced in women side and male
Property side between migrate mutually, even across transporting and store for a long time, after taking out sheath, which is still able to maintain tool
There are " asymmetry " reagent and its function of women side and male side.
Preferably, the sky in the sealing step, in the container at least side contacted with the sheath rolled
Between and its packaging material be in compressible situation, by vacuumizing so that the air pressure in container is less than air pressure outside container.As a result,
Lantern ring and mantle can be by the extruding of container, so that being isolated between the women side and male side of sheath, to reduce examination
Agent migrates mutually between the women side and male side of sheath.
Preferably, the sky in the sealing step, in the container at least side contacted with the sheath rolled
Between and its packaging material be, by being sealed in low-voltage space to the container, to be placed in normal gas in compressible situation
Behind pressure ring border, so that the air pressure in container is less than the air pressure outside container.As a result, lantern ring and mantle can by the extruding of container,
So that being mutually isolated between the women side and male side of sheath, to reduce reagent in the women side and male side of sheath
Between migrate mutually.
It should be noted that the low-voltage space refers to that the equipment being sealed is placed in an air pressure less than normal environment
Atmospheric pressure can be in operating space, in this way, being formed in the container when the container of sealing is transferred to normal environment
Outer draught head makes directly to squeeze the lantern ring and mantle between the container so that the women side and male side of sheath it
Between be mutually isolated, migrated mutually with reducing reagent between the women side and male side of sheath.
Preferably, air pressure 0.002~0.095 megapascal (MPa) smaller than container external pressure inside the container；Most preferably
Ground, air pressure 0.005~0.090 megapascal (MPa) smaller than container external pressure inside the container.The present inventor is through test of many times
It was found that when container internal and external pressure difference within the above range when, reagent can be effectively reduced in the women side and male side of sheath
Between migrate mutually, both made by transporting and store for a long time, after taking out sheath, between the women side and male side of sheath
Still it is isolated, reagent can be reduced and migrated mutually between the women side and male side of sheath.
In conclusion the invention has the benefit that
The present invention provides a kind of improved sheath system, between the women side and male side in this sheath system mutually
It being isolated, it is possible to reduce reagent migrates mutually between the women side and male side of sheath, by transporting and storing for a long time,
Taken out from the container and when using sheath, sheath keep sheath women side and male side " asymmetry " reagent and
Its function.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for the sheath rolled；
Fig. 2 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 3 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 4 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 5 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 6 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 7 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 8 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Fig. 9 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Figure 10 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Figure 11 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Figure 12 is one of the container of Figure 11 structural schematic diagram；
Figure 13 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Figure 14 is one of the container of Figure 13 structural schematic diagram；
Figure 15 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention
Figure 16 is a kind of oblique view of structural diagram of embodiment of sheath system of the present invention；
Figure 17 is the schematic cross-sectional view of the container of Figure 16；
Figure 18 is a kind of oblique view of structural diagram of embodiment of sheath system of the present invention；
Figure 19 is a kind of schematic cross-sectional view of embodiment of sheath system of the present invention；
Figure 20 is one of the container of Figure 19 structural schematic diagram；
Wherein, 1, closed end, 2, lantern ring, 3, mantle women side, 4, mantle male side, 5, lantern ring upside, 6, lantern ring downside,
7, on the inside of lantern ring, 8, on the outside of lantern ring, 9, container, 10, hard box body, 11, lid, 12, annular groove, 13, columnar projections, 14, prominent
Out, 15, hardboard, 16, sunk structure, 17, handle, 18, low ebb, 19, uncinus, 20, soft bag, 21, plate.
Specific embodiment
" migration " of the present invention refers to that certain reagent for rolling sheath side is transferred to and keeps away through flowing or being extruded
The pregnant set other side, including migrated from male side and migrate to women side, from women side to male side and moved mutually between two sides
It moves, does not include the reagent for being transferred to and being adhered in container inside and lantern ring.
" mobility " of the present invention, when referring to that sheath is rolled in taking-up from the packaging of sealing, contained by side
The amount (the referred to as the amount of migration of the reagent) from certain reagent of the other side is migrated, accounts for the amount of the remaining reagent in the other side (referred to as
The surplus of the reagent) ratio with the sum of the amount of migration of the reagent.
Certain reagent note that certain reagent for the women side for being added to sheath when by packaging is denoted as F, is added to male side
For M.After transporting and storing, when taking out sheath from the packaging of sealing, the surplus of the F reagent in women side is remembered
For fIt is surplus, the amount of migration that will migrate into the M reagent in women side be denoted as mIt moves；The surplus of M reagent in male side is denoted as mIt is surplus, will
The amount of migration for moving to the F reagent in male side is denoted as fIt moves.The calculation formula for then defining the mobility of both direction is respectively as follows:
Mobility of the M reagent from male side to women side: RMale=mIt moves/(mIt is surplus+mIt moves)；
Mobility of the F reagent from women side to male side: RFemale=fIt moves/(fIt is surplus+fIt moves)。
The mobility defines the height for reflecting the symmetry of the sheath two sides reagent type and amount rolled；Certain reagent
Mobility closer to 0, show that the amount of the reagent is lower in the symmetry of two sides, the mobility of certain reagent closer to 50%,
Show that the amount of the reagent is higher in the symmetry of two sides.
When certain reagent of addition dissolution or dispersion in the sheath side rolled, the surplus of the reagent and to another
Processing, right respectively again can be further purified when necessary respectively by the amount of collected every side reagent in the amount of migration of side
It is (such as various based on absorption/scattering/excitation chromatography, liquid/vapor/mass spectral analysis, element that the reagent does quantitative analysis
Analysis, scanning analysis, activity analysis etc.) and obtain, finally by the surplus of every side reagent and the amount of migration bring into it is above-mentioned in terms of
It calculates formula and obtains corresponding mobility.
For the sheath in the embodiment of the present invention:
For the natural latex condom of commercial run production；Its mantle thicknesses is 50 μm, length 188mm, just after rolling
Internal-and external diameter under round be respectively 30mm and 37mm, lantern ring diameter be 3.5mm；The above numerical value is average value.
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with the drawings and specific embodiments pair
The present invention is described further.
Embodiment 1
A kind of embodiment of sheath system of the invention, as shown in Fig. 2, including the container of the sheath rolled and sealing
9, the sheath rolled is set in container 9, and the sheath rolled includes lantern ring 2, the women side 3 for the sheath being mutually isolated and male
Property side 4, the lid 11 of hard box body 10 and aluminum-plastic composite membrane that container 9 is pressed by PVC material seals, lantern ring 2 and container 9
Hard box body 10 bottom and lid 11 connect, to form the women side 3 and male side 4 of the sheath that are mutually isolated；Rigid packet
The height of the slot of body 10 is smaller than the diameter of lantern ring 2, and the sheath and/or container rolled are added with reagent.
Embodiment 2
A kind of embodiment of sheath system of the invention, as shown in figure 3, the container 9 is including soft bag 20 and by hard
Multilayered structure made of material, the sheath are set in soft bag 20, then are set in every layer of multilayered structure, and about each layer
Laminate 21 is directly or indirectly applied with pressure to lantern ring 2.
Embodiment 3
A kind of embodiment of sheath system of the invention, as shown in figure 4, including the sheath and container 9 rolled, volume
The sheath risen is set in container 9, and the sheath rolled includes the women side 3 and male side of lantern ring 2, the sheath being mutually isolated
4, the sheath and/or container 9 rolled are interior added with reagent, the hard box body 10 and plastic-aluminum that container 9 is pressed by PVC material
The lid 11 of composite membrane seals, and annular groove 12 is equipped in container 9, and the width of annular groove 12 is less than or equal to lantern ring 2
Diameter+1.5mm, lantern ring 2 are embedded in annular groove 12, and the side wall of the annular groove 12 in 2 inner side and outer side of lantern ring and container connects
It connects, to form the women side 3 and male side 4 of the sheath being mutually isolated.
Wherein, the inside and outside contour of the horizontal cross-section of annular groove 12 is circle, annular groove 12 and the fixed company of container 9
It connects.
Embodiment 4
A kind of embodiment of sheath system of the invention, as shown in figure 5, including the sheath and container 9 rolled, volume
The sheath risen is set in container 9, and the sheath rolled includes the women side 3 and male side of lantern ring 2, the sheath being mutually isolated
4, the sheath and/or container 9 rolled are interior added with reagent, and container 9 is soft bag, lantern ring 2 and mantle made of aluminum-plastic composite membrane
It is connect with container 9 because of negative pressure, to form the women side 3 and male side 4 of the sheath being mutually isolated, 9 air pressure inside of container is small
In 9 external pressure of container, 9 internal and external pressure difference of container is 0.045 megapascal (MPa).
Embodiment 5
A kind of embodiment of sheath system of the invention, as shown in fig. 6, including the sheath and container 9 rolled, volume
The sheath risen is set in container 9, and the sheath rolled includes the women side 3 and male side of lantern ring 2, the sheath being mutually isolated
4, the sheath and/or container 9 rolled are interior added with reagent, and container 9 is made of PET (polyethylene terephthalate) material
The heat-sealing of the lid 11 of hard box body 10 and aluminum-plastic composite membrane, container 9 is interior to be equipped with columnar projections 13, and 2 sets of lantern ring in columnar projections 13
On, it connect the male side of lantern ring 2 and mantle with container cylindrical protrusion 13, to form the women side for the sheath being mutually isolated
3 and male side 4.
Wherein, the minimum outer perimeter of columnar projections 13 is greater than or equal to the interior perimeter of lantern ring 2, the level of columnar projections 13
The outer profile of section is ellipse, and 13 inner sidewall of columnar projections has prominent 14, and columnar projections 13 are fixedly connected with container 9.
Embodiment 6
A kind of embodiment of sheath system of the invention, as shown in fig. 7, comprises the sheath and container 9 rolled, hold
Device 9 includes hard box body 10 and aluminum foil cover 11 made of PS (polystyrene), and the groove height of hard box body 10 is less than the straight of lantern ring 2
Diameter.
The sheath rolled is set in container 9, and 9 air pressure inside of container is less than 9 external pressure of container, 9 inner and outer air pressure of container
Difference is 0.002~0.095 megapascal (MPa)；Lantern ring 2 and mantle are connect with the bottom of hard box body and lid 11, are mutually separated by with being formed
From sheath women side 3 and male side 4.
Embodiment 7
A kind of embodiment of sheath system of the invention, as shown in figure 8, including the sheath and container 9 rolled, volume
The sheath risen is set in container 9, and the sheath rolled includes the women side 3 and male side of lantern ring 2, the sheath being mutually isolated
4, container 9 includes the lid 11 of hard box body 10 and aluminum-plastic composite membrane, is equipped with annular groove 12, the sheath set rolled in container 9
Ring 2 is embedded in annular groove 12, and lantern ring 2 is connect with the side wall of the annular groove 12 in container 9 and lid 11, is mutually isolated with being formed
Contraception women side 3 and male side 4.
Wherein, the height of annular groove 12 is less than the diameter of lantern ring 2, and the width of annular groove 12 is less than or equal to lantern ring 2
Diameter+1.5mm, the outer profile of the horizontal cross-section of annular groove 12 is closed decagon, and annular groove 12 and container 9 are fixed
Connection.
Wherein, 9 air pressure inside of container is less than 9 external pressure of container, and 9 internal and external pressure difference of container is 0.002~0.095 million
Pascal.
Embodiment 8
A kind of embodiment of the packaging method of sheath system of the invention, the sheath system include the contraception rolled
Set and container, comprising the following steps:
(1) by lubricant, AntiHIV1 RT activity reagent, anti-erectile dysfunction reagent, anti-premature ejaculation reagent, anti-infective agents, hemostasis agents,
Enhance one of sexual desire reagent or a variety of additions at the sheath and container at least one on；
(2) the women side and male side of the sheath is isolated；And
(3) sheath is sealed in and completes to encapsulate in container.
Wherein, in step (2), the women side that pressure makes sheath is applied by lantern ring to sheath and/or mantle
It is mutually isolated between male side, the pressure that sheath lantern ring and/or mantle are subject to is 0.196~98 newton；And/or it can lead to
Cross vacuumize so that in container air pressure be less than container outer gas pressure realize, container internal and external pressure difference be 0.002~0.095 megapascal this
Card；
Alternatively, step (2) and step (3) sequence are exchanged: first being completed under low-voltage space (lower than the normal barometric pressure of surrounding)
Step (3)；It is packaged be placed on normal environment after, complete step (2), container internal and external pressure difference be 0.002~0.095 megapascal this
Card.
Embodiment 9
A kind of embodiment of the packaging method of sheath system of the invention, compared with Example 8, difference is only that: step
Suddenly the sequence of (1) and (2) is exchanged.
Embodiment 10
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as shown in Figure 9.
The sheath that 440 are rolled, S1、R1Two groups respectively have 140, remaining 160 are divided into S, S2、 R、R2Four groups；
Respectively in the asymmetric dimethicone for adding 800mg and 160mg in women side 3 and male side 4 of every sheath, wherein male
The evenly dispersed benzocainum for having 10mg of silicone oil of property side.
S、S1、S2Three groups of container 9 includes transparent plastic hardboard 15 and clad aluminum plastic film.S,S1、S2Three groups of sheath
Lantern ring the upper side and lower side is 37mm with diameter, uniformly clamps with a thickness of the transparent plastic hardboard 15 of 1.8mm, uses composite aluminium plastic
Film fits closely plastic hard board 15, hot pressurization.Clad aluminum plastic film squeezes plastic hard board 15 and is formed to lantern ring upper and lower sides
Pressure.R,R1、R2Three groups of sheaths are then directly with the heating sealing of clad aluminum plastic film.
Piezometry: it is identical as the measurement time point of mobility, it takes respectively every group packaged and storing different time
Sheath each 4, the average value H of the actual height of its sheath lantern ring under encapsulation state is measured,；Take it is same amount of not
The sheath sample of encapsulation, upper and lower sides are uniformly clamped with same hardboard, are uniformly pressed on press machine from upper and lower two sides, until
The height of sheath lantern ring reaches each group of corresponding H value, and corresponding pressure reading is hardboard in packaged sample to lantern ring at this time
The pressure value of upper and lower sides.After measured, S, S1、S2Average pressure value suffered by sheath lantern ring is 0.98 ± 0.1 N in three groups
, R, R1、R2Three groups of respective value is 0 newton；Said determination value is with the extension of storage time without significant changes.
Placement condition: in order to simulate sheath transporting in reality and condition of storage, by the sheath sample of sealing point
It is stored at three kinds of methods, S group and R group standing, S1Group and R1Group low speed rotation (2 revs/min), S2Group and R2Group high speed rotation
(120 revs/min).
Mobility measures: it for the sample of rotation group, needs to stand 15 minutes or so before sampling.Every group of every sub-sampling 4 is used
HPLC measures benzocainum in lubricant in the surplus and the amount of migration of sheath two sides respectively, and calculates lubricant from sheath
Male side to women side mobility (RMale) average value.As a result summarize such as table 1a.
Table 1a different time points each group RMale
The result shows that in the upper side and lower side for the sheath lantern ring rolled hardboard and then after being sealed with flexible container, it can
With the upper and lower sides pressure to lantern ring, and make male side moving to women side of the benzocainum from sheath under the conditions of different rotary
Shifting rate (RMale) substantially zeroed, lubricant is maintained in " asymmetry " for rolling sheath two sides；And it directly encapsulated, had using soft bag
There is the sheath being pressurized, under similarity condition, the mobility (R of benzocainumMale) then obvious quickening, wherein applying rotation
Later then further speed, final two sides lubricant tends to be symmetrical substantially.
It takes and stores 8 weeks or more S according to above-mentioned condition1、R1Each 100 sheaths are voluntary for 50 males in two groups
The usage experience of person is tested.Each volunteer uses two S at random respectively1Sample and two R1Sample, experiencer fill out according to questionnaire
Write using effect.Wherein main result is summarized as follows table 1b.
Table 1b volunteer experience comparing result on probation
The result shows that volunteer three primary experience indexs (gauffer occurs for mantle, there is sheath slide downward and
Need to be lifted up and women be since benzocainum in the amount of migration in women side causes its property susceptibility to decline) in,
S1Group is significantly better than that R1Group.
Embodiment 11
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as shown in Figure 10.
Container 9 is equipped with two pieces of curved surface hardboards 15 being connected to one with container, and container and curved surface hardboard are by polypropylene
(PP) material is made.Sheath is placed in container 9, is added with reagent in container, and two pieces of hardboards are from upper and lower two sides respectively to keeping away
The women side 3 of pregnant set mantle and male side 4 press, and form women side and male side 4 and the lantern ring of the sheath being mutually isolated
2。
The sheath that 50 are rolled is divided into S and two groups of R, every is added the water-soluble profit of 0.8ml in women side
Lubrication prescription and 90mg Policresulen.In S group, sheath is put into hot sealing in said vesse.R group sheath then uses routine
Condom casing, with the heat-sealing of clad aluminum plastic film.Above-mentioned two groups of sheaths being sealed are placed in low speed rotation (2 revs/min)
Middle storage.
Analysis method: in different time points, taking 5 sheaths from every group, and the reagent for drawing every side respectively merges；
Assay is carried out to Policresulen with HPLC.
According to the surplus and the amount of migration of lantern ring two sides Policresulen, Policresulen is calculated from women side to male side
Mobility (RFemale), as a result summarize such as table 2.
2 different time points each group R of tableFemale
The result shows that after the sheath mantle rolled in S group is pushed down by hardboard in two sides, the set for the sheath two sides rolled
Film is isolated, under above-mentioned rotating condition, mobility (R of the Policresulen from women side to male sideFemale) equal in different time
Remain zero；And the intracorporal sheath of ordinary rigid box is sealed in R group, due to not forming isolation effect, Policresulen
Mobility (R from women side to male sideFemale) then quickly increase, tend to be symmetrical in two sides quickly.
Embodiment 12
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as is illustrated by figs. 11 and 12.
The sheath that 325 are rolled is divided into S1~S12Group, R group, every is added the dimethicone of 600mg in keeping away
The women side 3 of pregnant set.R group as control, directly with after soft clad aluminum plastic film sealing wait rotate.In S1~S12Every of every group
A circular hollow hardboard 15 is placed in 2 inside 7 of lantern ring of sheath, and the outer diameter of hardboard is 30mm, with a thickness of 3mm；Then exist
The two sides of every sheath use soft clad aluminum plastic film, after being evacuated to different negative pressure with the vacuum plastic sealing machine with pressure gauge
Heating sealing.The negative pressure in sealed package is directly displayed on pressure gauge.It is 40 DEG C, high speed rotation that each group, which is all set in temperature,
The surplus and the amount of migration of the lubricant of every side is measured by sampling in different time in the condition storage of (120 revs/min), and with
This computation migration rate (RFemale).As a result such as the following table 3.
3 different time points each group mobility (R of tableFemale) variation
The result shows that being able to maintain lubricant when having negative pressure in the soft bag of sealing in storage and rotary course and existing
Certain " asymmetry " of sheath two sides；When in the soft bag of sealing it is evacuated to negative pressure be 0.002~0.095 megapascal this
When between card, it can be formed and be effectively isolated between sheath two sides, and the above-mentioned circular hollow hardboard on the inside of lantern ring limits lantern ring
Isolation effect is moved and preferably kept in the packaging of sealing, at this time lubricant mobility at high speed rotation 8 weeks still very
It is low, preferably maintain " asymmetry " of lubricant；When the negative pressure being evacuated in sealed package is higher than 0.095 megapascal (MPa)
When, excessively high pressure makes partial lubrication agent squeeze out mantle women side 3.
Embodiment 13
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as shown in Figure 13 and Figure 14.
As shown in figure 13, container 9 is soft bag made of clad aluminum plastic film, is equipped with columnar projections 13, columnar projections in soft bag
It as shown in figure 14, is cylindrical body (outer perimeter 104mm, high 4.5mm), there is segment-shaped sunk structure 16 in the middle section of columnar projections
The top side wall of (volume 0.42ml), columnar projections are equipped with 4 prominent 14 (preventing falling off for sheath lantern ring), columnar projections
Sidewall bottom be equipped with 2 handles 17, conveniently take sheath.
The sheath that 240 are rolled is divided into S, S1、S2、R、R1、R2It six groups, is added in the women side of every sheath
The water-based lubricant and 40mg metronidazole of 0.8ml, the same water-based profit of addition 0.25ml in the male side of every sheath
Lubrication prescription and 5mg lidocaine hydrochloride.
In S, S1、S2In three groups, then 2 sets of the sheath lantern ring outsides in above-mentioned columnar projections set columnar projections 13
It is sealed in above-mentioned soft bag.R,R1、R2Three groups are control, directly with the heating sealing of clad aluminum plastic film.
The method for measuring pressure on the inside of sheath lantern ring: the middle position week of lantern ring of the measuring unit in above-mentioned columnar projections
Long C (i.e. the average value of perimeter and outer perimeter in lantern ring)；Corresponding to above-mentioned each group of C value, 10 sheaths, Yu La are separately taken
When lantern ring being pulled to that wherein position perimeter is equal with C on power machine, corresponding value of thrust divided by 2 be on the inside of lantern ring suffered by pressure
Value.
Pressure measured value on the inside of each group sheath lantern ring: S, S1、S2Three groups are 4.9 ± 0.5 newton, R, R1、R2Three
Group is 0 newton；These pressure values do not have significant changes with the difference for the sheath storage time and condition being sealed.
Condition of storage: it transports and stores to simulate, by S, S1、S2、R、R1、R2Six groups are placed at different conditions, are placed
Condition is the same as embodiment 10.
Mobility measures: in different time points, taking 4 sheaths from every group, and the reagent for drawing every side respectively closes
And；The assay for carrying out each reagent respectively with HPLC obtains lidocaine hydrochloride and metronidazole respectively in male side and women
The surplus and the amount of migration of side, the mobility of reagent is calculated with this.
Mobility result such as the following table 4.Wherein, RMaleMobility for reagent hydrochloric acid lidocaine from male side to women side,
RFemaleMobility for reagent metronidazole from women side to male side.
Mobility (the R of drug in 4 different time points each group of tableMaleAnd RFemale)
The result shows that it is directly encapsulated into the sheath rolled in soft bag, the mobility of two kinds of reagents between two sides
At the 4-8 weeks already close to 50% (symmetrical)；And it is right to be inserted in above-mentioned columnar projections on the inside of the sheath lantern ring rolled
In the sample sealed again afterwards, either stands or under the conditions of different rotary, reagent added by the every side of lantern ring is not sent out
Raw migration keeps that there are both reagents to be formed by asymmetry in addition.
Embodiment 14
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as shown in figure 15.
Be equipped with cylindrical bump 13 in container 9, a diameter of 25mm, high 5.0mm, columnar projections middle section be equipped with ball
Lack 16 (hollow volume 0.7ml) of shape recess.
The sheath that 50 are rolled is divided into S and two groups of R, every is added the water-based lubricant and 50mg of 0.5ml
Tranexamic acid is in women side 3.In S group, 5 are put into above-mentioned columnar projections on the inside of sheath lantern ring, and hot with clad aluminum plastic film
Means of press seals.Clad aluminum plastic film and columnar projections clamp closed end and press to closed end mantle, the reagent of closed end and women side
It is housed inside in segment-shaped recess.R group sheath is then directly sealed with clad aluminum plastic film.Above-mentioned two groups of sheaths being sealed are equal
It is placed in storage in low speed rotation (2 revs/min).
Analysis method: in different time points, taking 5 sheaths from every group, and the reagent for drawing every side respectively merges,
The assay of tranexamic acid is carried out with HPLC.
According to the surplus and the amount of migration of the every side tranexamic acid of sheath, women side of the tranexamic acid from sheath is calculated
To the mobility (R of male sideFemale), as a result summarize such as table 5.
5 different time points each group R of tableFemale
The result shows that being revolved after above-mentioned columnar projections structure is added in packaging and only presses to sheath mantle in low speed
Under the conditions of turning, mobility (R of the tranexamic acid from women side to male sideFemale) in different time remain zero；And it is sealed in soft
Sheath in bag, mobility (R of the tranexamic acid from women side to male sideFemale) then quickly increase, tend to pair in two sides quickly
Claim.
Embodiment 15
A kind of embodiment of the isolation effect of sheath system of the invention is tested, as shown in Figure 16 and Figure 17.
Be equipped with annular groove 12 in container 9, high 4.0mm, its top maximum width be 3.8mm, circular arc-shaped bottom portion it is straight
Diameter is 3.3mm, and the inner wall of annular groove upwardly extends to be formed columnar projections 13 (a length of 95.8mm in periphery), in columnar projections
Between be partially equipped with segment-shaped and be recessed 16 (hollow volume 0.42ml), it is (outstanding that the inner wall of annular groove is equipped at three prominent 14
Maximum point is 0.6mm), annular groove one at extend low ebb 18 in the slope outward and (kept away so that finger takes out under low ebb
Pregnant set), the bottom of low ebb is 1.5mm lower than the bottom of annular groove.
The sheath that 120 are rolled is divided into S, S1、S2、R、R1、R2Six groups, every is added the dimethyl of 800mg
Silicone oil is in women side.S, the lantern ring of tri- groups of S1, S2 of sheath is placed in the annular groove of above-mentioned hard box body and uses plastic-aluminum
Film hot sealing.R,R1、R2Three groups of sheaths are then directly with the heating sealing of clad aluminum plastic film.
Placement condition: S group and R group stand storage, S1Group and R1Group in the low speed rotation (2 revs/min) storage, S2 group and
The storage in high speed rotation (120 revs/min) of R2 group.
Measuring method: the surpluses and the amount of migration of 4 measurement two sides lubricants are taken in various in different time points, and are counted
Calculate mobility (R of the dimethicone from women side to male sideFemale).As a result summarize such as table 6.
6 different time points each group R of tableFemale
The result shows that after the sheath lantern ring rolled is embedded in above-mentioned groove structure, under different time and rotating condition, two
Mobility (R of the methyl-silicone oil from women side to male sideFemale) keep very low, it highly maintains lubricant and is rolling sheath two sides
" asymmetry "；And it is sealed directly to the sheath in soft bag, and under same time and condition, the mobility of dimethicone
Considerably more rapid, wherein then further speeding after applying rotation, final two sides lubricant tends to be symmetrical substantially.
Embodiment 16
The sheath system of the present embodiment is compared with embodiment 15, other all the same in addition to following content: annular groove
At the one of 12 since arc-shaped bottom, having deep wide shallow slot sample low ebb 18, (depth 0.5mm, width are
5mm)；The uncinus 19 of a similar shape can be put into the low ebb 18 of shallow slot sample, after being put into uncinus 19, total is formed
One complete annular groove (referring to Figure 18).
Using with the identical experimental program of embodiment 15 and method, obtain dimethicone moving from women side to male side
Shifting rate (RFemale).As a result summarize such as table 7.
7 different time points each group R of tableFemale
The result shows that after the sheath lantern ring rolled is embedded in above-mentioned groove structure, it is high under different time and rotating condition
Degree maintains dimethicone in " asymmetry " for rolling sheath two sides；And the sheath in soft bag is sealed directly in two sides
Dimethicone tend to be symmetrical quickly.
Embodiment 17
A kind of embodiment of sheath system of the invention, as illustrated in figures 19 and 20.Inside and outside two layers of column is equipped in container
Shape protrusion 13, wherein the columnar projections of internal layer are evenly distributed by octagon for the cylindrical body for being 6.0mm by 8 diameters, wherein
The columnar projections of outer layer be 8mm by 8 diameters cylinder it is evenly distributed by octagon, make each outer cylinder with
Minimum clearance between two adjacent inner cylinders is impartial.
1-17 of the embodiment of the present invention condom products provided are detected according to ISO4074-2015, result is to close
Lattice.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should be managed
Solution can be combined technical solution of the present invention, modify or equivalent replacement, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (34)
1. a kind of sheath system, which is characterized in that including the sheath and container rolled, the sheath rolled is set to
In the container, the sheath rolled includes lantern ring, the mantle women side and male side that are mutually isolated.
2. sheath system according to claim 1, which is characterized in that the lantern ring and/or mantle and the container connect
It connects to form the women side and male side of the sheath being mutually isolated.
3. described in any item sheath systems according to claim 1~2, which is characterized in that the sheath rolled and/or
It is added with reagent in container, the reagent is lubricant, AntiHIV1 RT activity reagent, anti-erectile dysfunction reagent, anti-premature ejaculation reagent, anti-infective
One of reagent, hemostasis agents, sexual desire Contrast agent are a variety of；
Preferably, the type of the reagent of the women side and male side of the sheath and/or amount are different.
4. described in any item sheath systems according to claim 1~3, which is characterized in that the container includes soft bag.
5. described in any item sheath systems according to claim 1~3, which is characterized in that the container is by hard material system
At.
6. sheath system according to claim 5, which is characterized in that the container include be made of hard material it is hard
Matter box body.
7. described in any item sheath systems according to claim 1~3, which is characterized in that the container includes hard box body
And soft bag.
8. according to the described in any item sheath systems of claim 6~7, which is characterized in that be equipped with and use in the rigid packet body
In the slot for placing sheath, the diameter of the lantern ring is greater than the height of the slot.
9. according to the described in any item sheath systems of claim 4~8, which is characterized in that it is convex to be equipped with column in the container
It rises, the lantern ring and/or set Membrane cover are in the columnar projections.
10. sheath system according to claim 9, which is characterized in that the side wall of the columnar projections is equipped at least
Prominent or invagination at one.
11. according to the described in any item sheath systems of claim 9~10, which is characterized in that the level of the columnar projections
The outer profile in section is closed curve, polygon or is linked to be by curve and straight line close-shaped.
12. according to the described in any item sheath systems of claim 9~11, which is characterized in that the centre of the columnar projections
With sunk structure.
13. according to the described in any item sheath systems of claim 9~12, which is characterized in that the columnar projections with it is described
Container is fixedly connected.
14. according to the described in any item sheath systems of claim 9~13, which is characterized in that the periphery of the columnar projections
The long interior perimeter for being greater than or equal to the lantern ring.
15. according to the described in any item sheath systems of claim 4~8, which is characterized in that the container includes annular groove
Structure, the lantern ring are embedded in the annular groove.
16. sheath system according to claim 15, which is characterized in that the side wall of the annular groove is equipped at least one
Place is prominent or invaginates.
17. 5~16 described in any item sheath systems according to claim 1, which is characterized in that the level of the annular groove
The Internal periphery in section is closed curve, polygon or is linked to be by curve and straight line close-shaped.
18. 5~17 described in any item sheath systems according to claim 1, which is characterized in that the inner wall of the annular groove
It upwardly extends to form a columnar projections, the centre of the columnar projections is equipped with sunk structure.
19. 5~16 or 18 described in any item sheath systems according to claim 1, which is characterized in that the annular groove
Outer wall and/or inner wall are arranged by multiple columnar projections and are formed, in the multiple columnar projections two adjacent columnar projections it
Between be equipped with gap.
20. 5~19 described in any item sheath systems according to claim 1, which is characterized in that the annular groove with it is described
Container is fixedly connected.
21. 5~20 described in any item sheath systems according to claim 1, which is characterized in that at the one of the annular groove
Low ebb is extended into outward.
22. 5~18,20~21 described in any item sheath systems according to claim 1, which is characterized in that the annular is recessed
The width of slot is less than or equal to the diameter+1.5mm of the lantern ring.
23. sheath system according to claim 15, which is characterized in that the bottom of the annular groove is arc, institute
The inner wall for stating annular groove upwardly extends to form columnar projections, and the centre of the columnar projections is equipped with sunk structure, the annular
The side wall of groove be equipped with it is prominent at least one, the annular groove one at extend low ebb in the slope, the low ebb outward
Bottom be lower than the annular groove bottom.
24. according to claim 4~9 or 15 described in any item sheath systems, which is characterized in that be equipped in the container hard
Plate, the upside of the hardboard and the sheath lantern ring, downside, inside, outside, mantle women side, in mantle male side extremely
Few side connection.
25. sheath system according to claim 24, which is characterized in that the hardboard at least one side is equipped with recess, institute
The edge for stating hardboard is connect at least side of the sheath lantern ring rolled and/or mantle.
26. according to the described in any item sheath systems of claim 24~25, which is characterized in that the hardboard and the container
It is fixedly connected.
27. according to the described in any item sheath systems of claim 6~8, which is characterized in that the hard box body includes multilayer
Structure, the sheath rolled are set in the multilayered structure.
28. described in any item sheath systems according to claim 1~27, which is characterized in that the lantern ring and/or mantle with
There is pressure between the container；
Preferably, the pressure value is 0.196~98 newton；
It is highly preferred that the pressure value is 0.490~49 newton.
29. described in any item sheath systems according to claim 1~28, which is characterized in that the air pressure inside the container
Less than external container air pressure；
Preferably, air pressure 0.002~0.095 megapascal (MPa) smaller than container external pressure inside the container；
It is highly preferred that air pressure 0.005~0.090 megapascal (MPa) smaller than container external pressure inside the container.
30. a kind of packaging method of sheath system, the sheath system include the sheath and container rolled, feature exists
In, comprising the following steps:
By lubricant, dissolution or the AntiHIV1 RT activity of dispersion reagent, anti-erectile dysfunction reagent, anti-premature ejaculation reagent, anti-infective agents, hemostasis
One of reagent, sexual desire Contrast agent or it is a variety of addition in the sheath and/or the container in；
The women side and male side of the sheath is isolated；And
Sheath is sealed in container；
After sealing, lantern ring and/or the mantle receiving of the sheath rolled have pressure.
31. packaging method according to claim 30, which is characterized in that by the isolation step and sealing step, to
Apply pressure between the lantern ring and/or mantle and the container of the sheath；
Preferably, the pressure that the sheath lantern ring and/or mantle are subject to is 0.196~98 newton；
It is highly preferred that the pressure that the sheath lantern ring and/or mantle are subject to is 0.490~49 newton.
32. packaging method according to claim 30, which is characterized in that in the sealing step, by vacuumizing so that
Air pressure in container is less than the outer air pressure of container, applies pressure between the sheath lantern ring and mantle and the container.
33. packaging method according to claim 30, which is characterized in that the sealing step is carried out in low-voltage space
Sealing applies so that the air pressure in container is less than the outer air pressure of container between the sheath lantern ring and mantle and the container
Pressure.
34. according to the described in any item packaging methods of claim 32~33, which is characterized in that the air pressure ratio inside the container
Small 0.002~0.095 megapascal (MPa) of external container air pressure；
Preferably, air pressure 0.005~0.090 megapascal (MPa) smaller than container external pressure inside the container.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910018430.9A CN109928062B (en) | 2019-01-07 | 2019-01-07 | Condom system and packaging method thereof |
| CN202110646228.8A CN113353448B (en) | 2019-01-07 | 2019-01-07 | Condom assembly |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910018430.9A CN109928062B (en) | 2019-01-07 | 2019-01-07 | Condom system and packaging method thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110646228.8A Division CN113353448B (en) | 2019-01-07 | 2019-01-07 | Condom assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109928062A true CN109928062A (en) | 2019-06-25 |
| CN109928062B CN109928062B (en) | 2021-04-30 |
Family
ID=66984951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910018430.9A Active CN109928062B (en) | 2019-01-07 | 2019-01-07 | Condom system and packaging method thereof |
| CN202110646228.8A Active CN113353448B (en) | 2019-01-07 | 2019-01-07 | Condom assembly |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110646228.8A Active CN113353448B (en) | 2019-01-07 | 2019-01-07 | Condom assembly |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN109928062B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251737A (en) * | 2019-08-06 | 2019-09-20 | 湖南优感觉生物科技有限公司 | A kind of latex prophylactic being added to sodium hyaluronate |
| CN110329659A (en) * | 2019-07-11 | 2019-10-15 | 广州万方健医药有限公司 | A kind of novel sealed packing box |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN109928062B (en) | 2021-04-30 |
| CN113353448B (en) | 2023-02-03 |
| CN113353448A (en) | 2021-09-07 |
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