CN109925299A - A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever - Google Patents
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever Download PDFInfo
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- CN109925299A CN109925299A CN201910319955.6A CN201910319955A CN109925299A CN 109925299 A CN109925299 A CN 109925299A CN 201910319955 A CN201910319955 A CN 201910319955A CN 109925299 A CN109925299 A CN 109925299A
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Abstract
The present invention relates to medical supplies technical fields; disclose a kind of preparation method of long-acting temperature-reducing paste of bringing down a fever; basal layer, gel layer and protective layer are specifically included, wherein gel layer after 20 ~ 40 parts of modified bacteria cellulose, 15 ~ 30 parts of gelatin, 10 ~ 20 parts of polyvinyl alcohol, solidifying 5 ~ 10 parts of the pearl of effect, 0.5 ~ 5 part of nanometer titanium dioxide titanium valve and 3 ~ 5 parts of obtained wet films of surfactant through boric acid solution immersion by being prepared.Antipyretic gel patch prepared by the present invention largely extends the curative effect for cooling of bringing down a fever, while having certain tack and low irritability, and preparing material is green environment protective biological material, preparation method is simple and efficient, it is environmentally protective, it is low in cost, it can industrialized production.
Description
Technical field
The present invention relates to medical supplies technical field, a kind of specific preparation method comprising long-acting temperature-reducing paste of bringing down a fever.
Background technique
Hydrogel is the gel using water as decentralized medium.Medical aquogel is based on wound care " moisture treatment " theory
It develops, the features such as drugloading rate is big, transdermal effect is good, quality controllable, good permeability, small skin irritation, becomes reason
The cutaneous penetration carrier thought.Hydrogel cold compress patch is using on gel fitting skin, and body surface skin temperature is transmitted to epoxy resin,
Heat is absorbed by hydrone in gel, takes away a large amount of heat by the evaporation of moisture, can promptly reduce skin surface part
Temperature, mitigates the burning heat sensation, feeling of pain and sensibility of local skin, to play the effect of Physical temperature-lowering and cold compress physical therapy.But
It is that the effect is unsatisfactory for general hydrogel cold compress, and cold compress cannot keep duration.
Bacteria cellulose (Bacterial cellulose, BC) refers under certain condition, mainly by acetic acid Pseudomonas
The general designation of the cellulose of acetobacter xylinum secretion synthesis, is a kind of biomaterial that purposes is very extensive.Compared with plant cellulose
Compared with they are the straight chain polymers being formed by connecting by glucopyranose monomer, but bacteria cellulose is with many unique
Property, such as nanoscale three-dimensional reticular structure, superpower retentiveness, purity, crystallinity are high, and elasticity modulus and tensile strength are high, good
Good biocompatibility and degradability etc., are widely used to the every field such as food, papermaking, medical material.BC is as wound
A wet and mild environment can be provided for wound site by hurting dressing, can be promoted wound healing, be mitigated pain and do not stay scab,
It will not avoid generating secondary injury when dressing with wound adhesion simultaneously.
In the prior art, have the largely report about the hydrogel patch for cooling of bringing down a fever, also have largely about hydrogel
The report of cold compress patch, however it is less for the antipyretic gel patch report of bacteria cellulose crosslinking preparation, and existing bring down a fever
Patch generally there are application loosely, unobvious and skin allergy the defect that cools down of bringing down a fever, therefore it is carried out upgrading be on
The inevitable trend of kind.
Summary of the invention
A kind of tack is provided the purpose of the present invention is to solve in the prior art insufficient, there is drop of persistently bringing down a fever
The bringing down a fever of mild low irritability cools down the preparation method of patch.
To achieve the goals above, technical solution provided by the invention are as follows:
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, is prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 10 ~ 30g/L, in 30 ~ 60
It is protected from light 2 ~ 8 h at DEG C, adds after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, washing to supernatant is
Until neutrality, modified bacteria cellulose is obtained；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: by modified bacteria cellulose, gelatin, polyvinyl alcohol, effect coagulate pearl, nanometer titanium dioxide titanium valve and
Surfactant is thoroughly mixed obtained wet film, which is soaked in 2 ~ 8 h in boric acid solution, and gel layer is made；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
Preferably, the basal layer is that silk is formed with viscous glue based fibre shuffling；The protective layer is PE film or PP
Film.
Preferably, effect ingredient accounts for 1 ~ 8% that effect coagulates pearl specific gravity, and functional component is by refrigerant comfortable essential oil and water
Cornstarch, microcrystalline cellulose, sucrose, lactose, any one or a few composition in hydroxypropyl methyl cellulose are solved, wherein clearly
Cool comfortable essential oil is by lavender oil, attar of rose, neroli oil, lemon, asbolin, any one or a few in eucalyptus leaf essential oil
Composition.
Preferably, the composition by weight of each ingredient is as follows in the gel layer: 20 ~ 40 parts of modified bacteria cellulose, gelatin
15 ~ 30 parts, 10 ~ 20 parts of polyvinyl alcohol, solidifying 5 ~ 10 parts of the pearl of effect, 0.5 ~ 5 part of nanometer titanium dioxide titanium valve and surfactant 3 ~ 5
Part.
Preferably, the surfactant is tween or glycerin monostearate.
Preferably, the preparation method of the boric acid solution is as follows: weighing the nothing that 2 ~ 4 parts of boric acid is dissolved in 80 ~ 120 parts
In bacterium water, refrigerated after 0.22 μm of membrane filtration to obtain the final product.
There is very much " ducts " inside the unique three-dimensional manometer fibrous reticular structure of bacteria cellulose, have good permeable and holds
Aqueous energy, can absorb the moisture of 60 ~ 700 times of its dry weights, these moisture mainly exist in the form of Free water.In order to improve it
Water holding capacity, the present invention are suitably modified and are modified to it.
The present invention can produce following the utility model has the advantages that the water that (1) present invention is formed by modified bacteria cellulose post-crosslinking
Gel adhesive, have special three-dimensional mesh structure, thus possess water suction, water conservation, water holding excellent properties, pass through the steaming of steam
Vaporization and absorber exterior heat amount are sent out, to persistently play the effect for cooling of bringing down a fever；(2) it is arranged in hydrogel layer powerful solidifying
Pearl ingredient, effect is coagulated pearl and will not be ruptured when gelling temp is not much different with body temperature, and when body surface prolonged hay fever is not moved back, effect coagulates pearl
Rupture, internal various functional components release, and the fast cooling of skin are realized, to widen the gel adhesive that cools down of bringing down a fever
Use scope, be not only suitable for generally generating heat, be also applied for the fever of prolonged hay fever, have significant therapeutic effect；(3) boron
Acid has certain slow releasing function as the gel that crosslinking agent is formed, and coagulates pearl in combination with the vaporization absorbing and cooling temperature and effect of steam
Rupture cooling collaboration use, largely further extend the time for cooling of bringing down a fever；(4) this gel adhesive has
It is without side-effects can be directly applied to body surface for certain tack and low irritability；(5) preparing material used in the present invention is
Green environment protective biological material, preparation method are simple and efficient, environmentally protective, low in cost, can industrialized production.
Specific embodiment
The present invention is described further below with reference to embodiment；Following embodiment is only used for clearly illustrating this hair
Bright objects, technical solutions and advantages can not be limited the scope of the invention with this.
Embodiment 1:
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, is prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 20g/L, is kept away at 30 DEG C
Light reaction 2h is added after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, until washing to supernatant is neutral,
Obtain modified bacteria cellulose；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: 20 parts of modified bacteria cellulose, 20 parts of gelatin, 20 parts of polyvinyl alcohol, effect are coagulated into 5 parts of pearl, received
0.5 part and 3 parts of tween of rice titanium dioxide powder is thoroughly mixed obtained wet film, which is soaked in 2 h in boric acid solution, makes
Obtain gel layer；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
Effect ingredient accounts for 6% that effect coagulates pearl specific gravity, and functional component is by lavender oil, hydrolysed corn starch, sucrose
Composition.
The preparation method of the boric acid solution is as follows: it weighs 2 parts of boric acid and is dissolved in 100 parts of sterile water, warp
It is refrigerated after 0.22 μm of membrane filtration to obtain the final product.
Embodiment 2:
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, is prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 10g/L, is kept away at 40 DEG C
6 h of light reaction is added after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, until washing to supernatant is neutral,
Obtain modified bacteria cellulose；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: by 30 parts of modified bacteria cellulose, 15 parts of gelatin, 10 parts of polyvinyl alcohol, effect coagulate 10 parts of pearl,
1 part and 4 parts of glycerin monostearate of nanometer titanium dioxide titanium valve is thoroughly mixed obtained wet film, and it is molten which is soaked in boric acid
Gel layer is made in 4 h in liquid；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
Effect ingredient accounts for 1% that effect coagulates pearl specific gravity, and functional component is by attar of rose, neroli oil, microcrystalline cellulose group
At.
The preparation method of the boric acid solution is as follows: weighing 4 parts of boric acid and is dissolved in 80 parts of sterile water, through 0.22
It is refrigerated after μm membrane filtration to obtain the final product.
Embodiment 3:
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, is prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 15g/L, is kept away at 50 DEG C
8 h of light reaction is added after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, until washing to supernatant is neutral,
Obtain modified bacteria cellulose；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: 35 parts of modified bacteria cellulose, 30 parts of gelatin, 15 parts of polyvinyl alcohol, effect are coagulated into 6 parts of pearl, received
5 parts and 5 parts of glycerin monostearate of rice titanium dioxide powder is thoroughly mixed obtained wet film, which is soaked in boric acid solution
In 8 h, be made gel layer；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
Effect ingredient accounts for 5 % that effect coagulates pearl specific gravity, and functional component is made of lemon, asbolin, lactose.
The preparation method of the boric acid solution is as follows: weighing 3 parts of boric acid and is dissolved in 90 parts of sterile water, through 0.22
It is refrigerated after μm membrane filtration to obtain the final product.
Embodiment 4:
A kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, is prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 30g/L, is kept away at 60 DEG C
5 h of light reaction is added after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, until washing to supernatant is neutral,
Obtain modified bacteria cellulose；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: 40 parts of modified bacteria cellulose, 25 parts of gelatin, 18 parts of polyvinyl alcohol, effect are coagulated into 8 parts of pearl, received
3 parts and 3 parts of tween of rice titanium dioxide powder is thoroughly mixed obtained wet film, which is soaked in 6 h in boric acid solution, is made
Gel layer；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
Effect ingredient accounts for 8% that effect coagulates pearl specific gravity, and functional component is by lavender oil, eucalyptus leaf essential oil, hydroxypropyl first
Base cellulose composition.
The preparation method of the boric acid solution is as follows: it weighs 4 parts of boric acid and is dissolved in 120 parts of sterile water, warp
It is refrigerated after 0.22 μm of membrane filtration to obtain the final product.
Embodiment 5: simulation cooling experiment
It is PC plate material of the 10cm with a thickness of 5cm by a length of 20cm wide, in distance length direction, the position mark of 4cm is point 1, successively
Being spaced 4cm is point 2, point 3, and puts 1, point 2, point 3 point-blank, and in plate center, later heats PC plate
It to 40 DEG C and remains that the heat source of the constant temperature heats, sticks embodiment one to four, and choose general conduct of bringing down a fever on the market
Vs comparative examples it is defervescence plaster used, these patches can be completely covered a little 1, point 2 and point 3, each point temperature is recorded with 2h, 4h, 6h, 8h
Degree, and set up blank group.
From above table as can be seen that in the case where heat source is stablized, compared to general similar product on the market, originally
The sustainable cooling of bringing down a fever of temperature-reducing paste of bringing down a fever that invention provides reaches 8 hours or more, and common defervescence plaster used product only 2 ~ 4 hours.
Therefore, present invention cooling effect of persistently bringing down a fever is very significant, greatly extends the temperature fall time of bringing down a fever of product.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (8)
1. a kind of preparation method of long-acting temperature-reducing paste of bringing down a fever, which is characterized in that be prepared by following processing step:
(1) modification of bacteria cellulose: bacteria cellulose is immersed in the sodium metaperiodate aqueous solution of 10 ~ 30g/L, in 30 ~ 60
It is protected from light 2 ~ 8 h at DEG C, adds after ethylene glycol carries out 2 h of reaction and is washed repeatedly with water and ethyl alcohol, washing to supernatant is
Until neutrality, modified bacteria cellulose is obtained；
(2) effect coagulates the preparation of pearl: reaction kettle is added in deionized water, keeps 40 DEG C of constant temperature, and function is added into reaction kettle
Ingredient is imitated, is evenly stirred until transparent no particle, effect is made with polyvinyl alcohol water soluble film package and coagulates pearl, it is spare；
(3) preparation of gel layer: by modified bacteria cellulose, gelatin, polyvinyl alcohol, effect coagulate pearl, nanometer titanium dioxide titanium valve and
Surfactant is thoroughly mixed obtained wet film, which is soaked in 2 ~ 8 h in boric acid solution, and gel layer is made；
(4) bonding substrates layer and protective layer are distinguished in gel layer two opposite side surfaces, obtain the long-acting temperature-reducing paste of bringing down a fever.
2. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that the basal layer is silk and glues
Glue based fibre shuffling forms；The protective layer is PE film or PP film.
3. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that it is solidifying that effect ingredient accounts for effect
The 1 ~ 8% of pearl specific gravity.
4. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that the functional component is by refrigerant comfortable
Essential oil and any one or a few group in hydrolysed corn starch, microcrystalline cellulose, sucrose, lactose, hydroxypropyl methyl cellulose
At.
5. long-acting defervescence plaster used preparation method as claimed in claim 4, which is characterized in that the refrigerant comfortable essential oil is by smoking clothing
Careless oil, attar of rose, neroli oil, lemon, asbolin, any one or a few composition in eucalyptus leaf essential oil.
6. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that each ingredient in the gel layer
Composition by weight is as follows: 20 ~ 40 parts of modified bacteria cellulose, 15 ~ 30 parts of gelatin, 10 ~ 20 parts of polyvinyl alcohol, effect coagulate pearl 5 ~ 10
0.5 ~ 5 part and 3 ~ 5 parts of surfactant of part, nanometer titanium dioxide titanium valve.
7. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that the surfactant is tween
Or glycerin monostearate.
8. long-acting defervescence plaster used preparation method as described in claim 1, which is characterized in that the preparation side of the boric acid solution
Method is as follows: weighing 2 ~ 4 parts of boric acid and is dissolved in 80 ~ 120 parts of sterile water, refrigerates after 0.22 μm of membrane filtration to obtain the final product.
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Citations (5)
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|---|---|---|---|---|
| WO2005003366A1 (en) * | 2003-07-03 | 2005-01-13 | Politechnika Lodzka | A method for the production of bacterial cellulose |
| US20070213522A1 (en) * | 2006-03-13 | 2007-09-13 | Xylos Corporation | Oxidized microbial cellulose and use thereof |
| CN102924613A (en) * | 2012-11-01 | 2013-02-13 | 海南大学 | Preparation method of dialdehyde bacterial cellulose |
| CN109369948A (en) * | 2018-09-06 | 2019-02-22 | 东华大学 | A kind of bacteria cellulose/polyvinyl alcohol anti-bacterial hydrogel and its preparation method and application |
| CN109481133A (en) * | 2018-09-21 | 2019-03-19 | 珠海国佳新材股份有限公司 | A kind of shield brain temperature-sensitive coagulates pearl medical gel patch and preparation method |
-
2019
- 2019-04-19 CN CN201910319955.6A patent/CN109925299A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005003366A1 (en) * | 2003-07-03 | 2005-01-13 | Politechnika Lodzka | A method for the production of bacterial cellulose |
| US20070213522A1 (en) * | 2006-03-13 | 2007-09-13 | Xylos Corporation | Oxidized microbial cellulose and use thereof |
| CN102924613A (en) * | 2012-11-01 | 2013-02-13 | 海南大学 | Preparation method of dialdehyde bacterial cellulose |
| CN109369948A (en) * | 2018-09-06 | 2019-02-22 | 东华大学 | A kind of bacteria cellulose/polyvinyl alcohol anti-bacterial hydrogel and its preparation method and application |
| CN109481133A (en) * | 2018-09-21 | 2019-03-19 | 珠海国佳新材股份有限公司 | A kind of shield brain temperature-sensitive coagulates pearl medical gel patch and preparation method |
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Application publication date: 20190625 |
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