CN109880015A - A kind of pediatric nursing anti-biotic material - Google Patents
A kind of pediatric nursing anti-biotic material Download PDFInfo
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- CN109880015A CN109880015A CN201910176995.XA CN201910176995A CN109880015A CN 109880015 A CN109880015 A CN 109880015A CN 201910176995 A CN201910176995 A CN 201910176995A CN 109880015 A CN109880015 A CN 109880015A
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Abstract
The invention discloses a kind of pediatric nursing anti-biotic materials, using being prepared following preparation method: (one) 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid, (2) preparation of Ag-Cu-Dy-O, (3) surface modification of Ag-Cu-Dy-O, the molding of (four) anti-biotic material.Pediatric nursing anti-biotic material disclosed by the invention has excellent combination property, and antibacterial effect is significant, good biocompatibility, and weatherability, anti-flammability, processing fluidity and mechanical mechanics property are excellent, the advantages of using safety and environmental protection.
Description
Technical field
The present invention relates to field of medical article technology more particularly to a kind of pediatric nursing anti-biotic materials.
Background technique
In recent years, as the progress of science and technology and economic fast development, medical industry are also quickly grown, but these benefits
Good also people to be prevent completely sick, especially children or juvenile are even more so.Since their immunity develop prematurity,
Sick in developmental process is the thing being difficult to avoid that.Children or juvenile are sick in hospital, usually need to contact in clinical care
To some materials, these materials have that cleaning is difficult, and bactericidal property is inadequate, there are infection risk, it is easily-deformable the problems such as, serious prestige
Coerce the health of medical staff and infant.
With the raising of quality of the life, people more refine the nursing of child, love degree of the parent to child
It is remote super previous.Seeking pediatric nursing anti-biotic material becomes the hot subject studied in the industry.Paediatrics shield common in the prior art
Manage anti-biotic material be mostly antibacterial medical polymer material, this kind of material have good biocompatibility, to tissue without
Irritation, nontoxicity, without allergic reaction, body rejection is few, and have good physicochemical property, but this kind of material be easy
Cause the growth and procreation of bacterium or microorganism, increases the danger of doctor and patient's infectious disease, in addition it is also more or less deposited
Resistance to UV aging is bad, anti-flammability, processing fluidity and wearability not enough, mechanical mechanics property needs to be further increased
Technological deficiency.
Currently, common antimicrobial macromolecule material be mostly using high-molecular compound as matrix, then equipped with filler, plasticizer,
The additives such as stabilizer, lubricant, colorant and antibacterial agent and be made, this kind of material due to addition additive and matrix compatibility
And itself dispersion problem, easily occur exosmose in the long-term use, causes material comprehensive performance unstable, use the longevity
Life is not grown.In addition, this kind of material antibiotic property is generally poor, jeopardize human-body safety, these defects limit it in pediatric nursing material
Expect the application of aspect.
Application No. is 200680000645.9 Chinese invention patents to disclose a kind of function with antimicrobial antiviral activity
Energy property nano material, using metal oxide Ag+And Cu2+With nonmetal oxide TiO2、ZnO、SiO2Nanometer material
Material, production process is more complicated, and not only anti-microbial property is weaker for the material, and its antiviral actual performance is more limited.
Therefore, it is significant to develop a kind of antibacterial effect, good biocompatibility, weatherability, anti-flammability, processing fluidity and machinery
The pediatric nursing anti-biotic material of excellent in mechanical performance has very important significance.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provides a kind of pediatric nursing anti-biotic material, and the pediatric nursing is anti-
It is poor that bacterium material overcomes traditional anti-biotic material antibacterial agent effect, and resistance to UV aging is bad, anti-flammability, processing fluidity and resistance to
Mill property is inadequate, mechanical mechanics property needs the technological deficiency further increased, has excellent combination property, and antibacterial effect is significant,
Good biocompatibility, weatherability, anti-flammability, processing fluidity and mechanical mechanics property are excellent, the advantages of using safety and environmental protection.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of pediatric nursing anti-biotic material, using such as
Lower preparation method is prepared:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides, poly-aspartate be added in organic solvent, after be stirred to react at 30-40 DEG C 18-22 hours, it is rear to rotate
Solvent is removed, is washed 3-5 times with ether, revolving removes ether, and it is modified to obtain 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides
Poly-aspartate；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate of chemistry, mantoquita, dysprosium salt are added in the beaker equipped with ethyl alcohol,
Stirring 2-3 hour after form solution, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner, 200-230 DEG C instead
It answers 15-18 hours；Reaction kettle is taken out, is then dried at 100 DEG C -110 DEG C in air dry oven, is cooled to room temperature rear ball milling,
And it is sintered 4-6h at 600-700 DEG C, it is cooled to room temperature, takes out grinding, cross 100-200 mesh and obtain Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: dispersing the Ag-Cu-Dy-O being prepared by step II in ethyl alcohol,
Two (3- tri-ethoxy silylpropyl) carbonic esters are added thereto again, are stirred to react at 60-80 DEG C, it is rear to filter, and use second
After alcohol is washed 3-5 times, it is placed in a vacuum drying oven at 80-90 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate, the Ag-Cu-Dy-O for the surface modification being prepared by step III, (in 1S-) -1,7,7- trimethyl it is double
Ring [2.2.1] hept- 2- base acrylate, hexafluoroacetylacetone zinc dihydrate, initiator are uniformly mixed, and are then added to double spiral shells
Extrusion molding is carried out in bar extruder, heat preservation stands 3-5 hours at nitrogen or 80-90 DEG C of atmosphere of inert gases again after discharging,
Obtain anti-biotic material.
Preferably, 1- described in step I [3- allyl oxygroup -2- hydroxypropyl] biguanides, poly-aspartate, organic solvent
Mass ratio be 1:2:(10-15).
Preferably, the organic solvent is selected from one or more of ethyl alcohol, methylene chloride, isopropanol.
Preferably, silver nitrate described in step II, mantoquita, dysprosium salt, ethyl alcohol mass ratio be 1:0.3:0.2:(4-6).
Preferably, the mantoquita is selected from one or more of copper nitrate, copper chloride, copper carbonate；The dysprosium salt is selected from nitre
At least one of sour dysprosium, dysprosium chloride.
Preferably, Ag-Cu-Dy-O described in step III, ethyl alcohol, two (3- tri-ethoxy silylpropyl) carbonic esters matter
Amount is than being 1:(3-5): 0.2.
Preferably, 1- described in step IV [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid, surface
Bicyclic [2.2.1] the hept- 2- base acrylate of the Ag-Cu-Dy-O of modification, (in 1S-) -1,7,7- trimethyl, hexafluoroacetylacetone
Zinc dihydrate, initiator mass ratio be 2:0.4:1:1:(0.02-0.04).
Preferably, the extrusion molding process are as follows: extrusion temperature is 230-250 DEG C, screw speed 1000-1200r/
min；The inert gas is selected from one of helium, neon, argon gas；The initiator is selected from azodiisobutyronitrile, azo two
At least one of different heptonitrile.
The beneficial effects of adopting the technical scheme are that
(1) pediatric nursing anti-biotic material provided by the invention, preparation method simple process is easy to operate, and raw material is easy to get, source
Abundant, nontoxic, preparation cost is cheap, and not high to device dependence, preparation condition is mild, is suitble to large-scale production.
(2) pediatric nursing anti-biotic material provided by the invention, it is poor to overcome traditional anti-biotic material antibacterial agent effect, uvioresistant
Ageing properties are bad, anti-flammability, processing fluidity and wearability not enough, mechanical mechanics property needs the technology further increased and lacks
It falls into, each ingredient and structure synergistic effect, so that material has excellent combination property, antibacterial effect is significant, good biocompatibility, resistance to
Hou Xing, anti-flammability, processing fluidity and mechanical mechanics property are excellent, the advantages of using safety and environmental protection.
(3) pediatric nursing anti-biotic material provided by the invention, by being modified poly-aspartate by poly-aspartate
It is introduced into material molecule chain, improves the biocompatibility of material, zinc is introduced into material molecule chain by the monomer containing zinc, with
Cyclic ester, biguanides in strand, inorganic molecule Ag-Cu-Dy-O synergistic effect, improve the antibacterial anti-infection performance of material；Point
Fluorine-containing building stone and diene hydrocarbon structure are introduced in subchain, in addition modified polyaspartic acid, can act as being crosslinked in formative stage
Site forms three-dimensional net structure, is conducive to the comprehensive performance for improving material；The addition of Ag-Cu-Dy-O not only increases material
Intensity, and make its anti-microbial property more preferably, biocompatible structure introduced by the way that surface is modified, so that material is with more life
Object compatibility is not likely to produce allergy or rejection, on the other hand, and can be enhanced its compatibility between other compositions and
Itself uniformly dispersed.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Wherein, the raw material is commercially available.
Embodiment 1
A kind of pediatric nursing anti-biotic material, using being prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides 1kg, poly-aspartate 2kg be added in ethyl alcohol 10kg, after be stirred to react at 30 DEG C 18 hours, it is rear to rotate
Solvent is removed, is washed 3 times with ether, revolving removes ether, and it is modified poly- to obtain 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides
Aspartic acid；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate 100g of chemistry, copper nitrate 30g, dysprosium nitrate 20g are added to and are equipped with
In the beaker of ethyl alcohol 400g, stirring formed solution after 2 hours, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner
In, it is reacted 15 hours at 200 DEG C；Reaction kettle is taken out, is then dried at 100 DEG C in air dry oven, is cooled to room temperature rear ball
Mill, and it is sintered 4h at 600 DEG C, it is cooled to room temperature, takes out grinding, sieve with 100 mesh sieve to obtain Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: second is dispersed by the Ag-Cu-Dy-O 100g being prepared by step II
In alcohol 300g, then two (3- tri-ethoxy silylpropyl) carbonic ester 20g are added thereto, are stirred to react at 60 DEG C, it is rear to take out
Filter, and after washing 3 times with ethyl alcohol, it is placed in a vacuum drying oven at 80 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate 200g, the Ag-Cu-Dy-O40g for the surface modification being prepared by step III, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate 100g, hexafluoroacetylacetone zinc dihydrate 100g, azodiisobutyronitrile 2g
It is uniformly mixed, is then added in double screw extruder and carries out extrusion molding, kept the temperature at 80 DEG C of nitrogen atmosphere again after discharging quiet
It sets 3 hours, obtains anti-biotic material；The extrusion molding process are as follows: extrusion temperature is 230 DEG C, screw speed 1000r/min.
Embodiment 2
A kind of pediatric nursing anti-biotic material, using being prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides 1kg, poly-aspartate 2kg be added in methylene chloride 11kg, after be stirred to react at 33 DEG C 19 hours, after
Revolving removes solvent, is washed 4 times with ether, and revolving removes ether, obtains 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides and changes
Property poly-aspartate；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate 100g of chemistry, copper chloride 30g, dysprosium chloride 20g are added to and are equipped with
In the beaker of ethyl alcohol 450g, stirring formed solution after 2.3 hours, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner
In, it is reacted 16 hours at 210 DEG C；Reaction kettle is taken out, is then dried at 103 DEG C in air dry oven, is cooled to room temperature rear ball
Mill, and it is sintered 4.5h at 630 DEG C, it is cooled to room temperature, takes out grinding, cross 130 meshes and obtain Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: second is dispersed by the Ag-Cu-Dy-O 100g being prepared by step II
In alcohol 350g, then two (3- tri-ethoxy silylpropyl) carbonic ester 20g are added thereto, are stirred to react at 65 DEG C, it is rear to take out
Filter, and after washing 4 times with ethyl alcohol, it is placed in a vacuum drying oven at 83 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate 200g, the Ag-Cu-Dy-O40g for the surface modification being prepared by step III, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate 100g, hexafluoroacetylacetone zinc dihydrate 100g, azobisisoheptonitrile
2.5g is uniformly mixed, and is then added in double screw extruder and is carried out extrusion molding, protects at 83 DEG C of helium atmosphere again after discharging
Temperature stands 3.5 hours, obtains anti-biotic material；The extrusion molding process are as follows: extrusion temperature is 235 DEG C, and screw speed is
1050r/min。
Embodiment 3
A kind of pediatric nursing anti-biotic material, using being prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides 1kg, poly-aspartate 2kg be added in isopropanol 13kg, after 20 hours are stirred to react at 35 DEG C, back spin
Solvent is evaporated off, is washed 4 times with ether, revolving removes ether, and it is modified to obtain 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides
Poly-aspartate；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate 100g of chemistry, copper carbonate 30g, dysprosium nitrate 20g are added to and are equipped with
In the beaker of ethyl alcohol 500g, stirring formed solution after 2.5 hours, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner
In, it is reacted 16.5 hours at 215 DEG C；Reaction kettle is taken out, is then dried at 106 DEG C in air dry oven, after being cooled to room temperature
Ball milling, and it is sintered 5h at 660 DEG C, it is cooled to room temperature, takes out grinding, cross 150 meshes and obtain Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: second is dispersed by the Ag-Cu-Dy-O 100g being prepared by step II
In alcohol 400g, then two (3- tri-ethoxy silylpropyl) carbonic ester 20g are added thereto, are stirred to react at 70 DEG C, it is rear to take out
Filter, and after washing 4 times with ethyl alcohol, it is placed in a vacuum drying oven at 85 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate 200g, the Ag-Cu-Dy-O40g for the surface modification being prepared by step III, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate 100g, hexafluoroacetylacetone zinc dihydrate 100g, azodiisobutyronitrile 3g
It is uniformly mixed, is then added in double screw extruder and carries out extrusion molding, kept the temperature at 85 DEG C of neon atmosphere again after discharging quiet
It sets 4 hours, obtains anti-biotic material；The extrusion molding process are as follows: extrusion temperature is 240 DEG C, screw speed 1100r/min；
The inert gas is selected from one of helium, neon, argon gas.
Embodiment 4
A kind of pediatric nursing anti-biotic material, using being prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides 1kg, poly-aspartate 2kg be added in organic solvent 14kg, after be stirred to react at 38 DEG C 21 hours, after
Revolving removes solvent, is washed 5 times with ether, and revolving removes ether, obtains 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides and changes
Property poly-aspartate；The organic solvent is the mixture that ethyl alcohol, methylene chloride, isopropanol 1:2:3 in mass ratio are mixed；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate 100g of chemistry, mantoquita 30g, dysprosium salt 20g are added to equipped with ethyl alcohol
In the beaker of 550g, stirring 2.8 hours after form solution, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner,
It is reacted 17.5 hours at 225 DEG C；Reaction kettle is taken out, is then dried at 108 DEG C in air dry oven, is cooled to room temperature rear ball
Mill, and it is sintered 5.8h at 680 DEG C, it is cooled to room temperature, takes out grinding, cross 180 meshes and obtain Ag-Cu-Dy-O；The mantoquita is nitre
The mixture that sour copper, copper chloride, copper carbonate 3:2:1 in mass ratio are mixed；The dysprosium salt is dysprosium nitrate, dysprosium chloride by quality
The mixture mixed than 3:5；
The surface modification of III Ag-Cu-Dy-O: second is dispersed by the Ag-Cu-Dy-O 100g being prepared by step II
In alcohol 480g, then two (3- tri-ethoxy silylpropyl) carbonic ester 20g are added thereto, are stirred to react at 78 DEG C, it is rear to take out
Filter, and after washing 5 times with ethyl alcohol, it is placed in a vacuum drying oven at 88 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate 200g, the Ag-Cu-Dy-O40g for the surface modification being prepared by step III, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate 100g, hexafluoroacetylacetone zinc dihydrate 100g, initiator 3.8g mixing
Uniformly, it is then added in double screw extruder and carries out extrusion molding, heat preservation stands 4.5 at 88 DEG C of argon atmosphere again after discharging
Hour, obtain anti-biotic material；The extrusion molding process are as follows: extrusion temperature is 245 DEG C, screw speed 1150r/min；It is described
Initiator is the mixture that azodiisobutyronitrile, azobisisoheptonitrile 2:5 in mass ratio are mixed.
Embodiment 5
A kind of pediatric nursing anti-biotic material, using being prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl
Base propyl] biguanides 1kg, poly-aspartate 2kg be added in isopropanol 15kg, after 22 hours are stirred to react at 40 DEG C, back spin
Solvent is evaporated off, is washed 5 times with ether, revolving removes ether, and it is modified to obtain 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides
Poly-aspartate；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate 100g of chemistry, copper nitrate 30g, dysprosium nitrate 20g are added to and are equipped with
In the beaker of ethyl alcohol 600g, stirring formed solution after 3 hours, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner
In, it is reacted 18 hours at 230 DEG C；Reaction kettle is taken out, is then dried at 110 DEG C in air dry oven, is cooled to room temperature rear ball
Mill, and it is sintered 6h at 700 DEG C, it is cooled to room temperature, takes out grinding, cross 200 meshes and obtain Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: second is dispersed by the Ag-Cu-Dy-O 100g being prepared by step II
In alcohol 500g, then two (3- tri-ethoxy silylpropyl) carbonic ester 20g are added thereto, are stirred to react at 80 DEG C, it is rear to take out
Filter, and after washing 5 times with ethyl alcohol, it is placed in a vacuum drying oven at 90 DEG C and dries to constant weight；
The molding of IV anti-biotic material: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is changed
Property poly-aspartate 200g, the Ag-Cu-Dy-O40g for the surface modification being prepared by step III, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate 100g, hexafluoroacetylacetone zinc dihydrate 100g, azodiisobutyronitrile 4g
It is uniformly mixed, is then added in double screw extruder and carries out extrusion molding, kept the temperature at 90 DEG C of nitrogen atmosphere again after discharging quiet
It sets 5 hours, obtains anti-biotic material；The extrusion molding process are as follows: extrusion temperature is 250 DEG C, screw speed 1200r/min.
Comparative example
A kind of medical antibacterial high molecular material, according to the formula system of 201611145774.9 embodiment 1 of Chinese invention patent
It is standby to form.
Above-described embodiment 1-5 and comparative example resulting materials are tested for the property, test method and test result are shown in Table
1。
Table 1
As seen from Table 1, pediatric nursing anti-biotic material disclosed by the embodiments of the present invention, compared with comparative example, antibiotic property and life
Object compatibility is more preferable, and mechanical property is more excellent.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (8)
1. a kind of pediatric nursing anti-biotic material, which is characterized in that use and be prepared following preparation method:
I 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid: by 1- [3- allyl oxygroup -2- hydroxyl third
Base] biguanides, poly-aspartate be added in organic solvent, after be stirred to react at 30-40 DEG C 18-22 hours, back spin is evaporated off
Solvent is washed 3-5 times with ether, and revolving removes ether, obtains the modified poly- day of 1- [3- allyl oxygroup -2- hydroxypropyl] biguanides
Aspartic acid；
The preparation of II Ag-Cu-Dy-O: the pure silver nitrate of chemistry, mantoquita, dysprosium salt are added in the beaker equipped with ethyl alcohol, stirred
Form solution after 2-3 hours, after transfer the solution into the hydrothermal reaction kettle of polyvinyl fluoride liner, in 200-230 DEG C of reaction 15-
18 hours；Reaction kettle is taken out, is then dried at 100 DEG C -110 DEG C in air dry oven, is cooled to room temperature rear ball milling, and
It is sintered 4-6h at 600-700 DEG C, is cooled to room temperature, grinding is taken out, 100-200 mesh is crossed and obtains Ag-Cu-Dy-O；
The surface modification of III Ag-Cu-Dy-O: dispersing the Ag-Cu-Dy-O being prepared by step II in ethyl alcohol, then to
Two (3- tri-ethoxy silylpropyl) carbonic esters are wherein added, are stirred to react at 60-80 DEG C, it is rear to filter, and washed with ethyl alcohol
After 3-5 times, it is placed in a vacuum drying oven at 80-90 DEG C and dries to constant weight；
IV anti-biotic material molding: 1- [the 3- allyl oxygroup -2- hydroxypropyl] biguanides being prepared by step I is modified poly-
Aspartic acid, the Ag-Cu-Dy-O for the surface modification being prepared by step III, (in 1S-) -1,7,7- trimethyl are bicyclic
[2.2.1] hept- 2- base acrylate, hexafluoroacetylacetone zinc dihydrate, initiator are uniformly mixed, and are then added to twin-screw
Extrusion molding is carried out in extruder, heat preservation stands 3-5 hours at nitrogen or 80-90 DEG C of atmosphere of inert gases again after discharging, obtains
To anti-biotic material.
2. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that [the 3- allyl of 1- described in step I
Base oxygroup -2- hydroxypropyl] biguanides, poly-aspartate, organic solvent mass ratio be 1:2:(10-15).
3. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that the organic solvent is selected from second
One or more of alcohol, methylene chloride, isopropanol.
4. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that silver nitrate described in step II,
Mantoquita, dysprosium salt, ethyl alcohol mass ratio be 1:0.3:0.2:(4-6).
5. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that the mantoquita be selected from copper nitrate,
One or more of copper chloride, copper carbonate；The dysprosium salt is selected from least one of dysprosium nitrate, dysprosium chloride.
6. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that Ag-Cu- described in step III
Dy-O, ethyl alcohol, two (3- tri-ethoxy silylpropyl) carbonic esters mass ratio be 1:(3-5): 0.2.
7. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that [the 3- alkene of 1- described in step IV
Propyl oxygroup -2- hydroxypropyl] biguanides modified polyaspartic acid, the Ag-Cu-Dy-O of surface modification, (in 1S-) -1,7,7- three
Methyl bicycle [2.2.1] hept- 2- base acrylate, hexafluoroacetylacetone zinc dihydrate, initiator mass ratio be 2:0.4:
1:1:(0.02-0.04)。
8. a kind of pediatric nursing anti-biotic material according to claim 1, which is characterized in that the extrusion molding process are as follows:
Extrusion temperature is 230-250 DEG C, screw speed 1000-1200r/min；The inert gas is in helium, neon, argon gas
One kind；The initiator is selected from least one of azodiisobutyronitrile, azobisisoheptonitrile.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104650298A (en) * | 2015-01-22 | 2015-05-27 | 上海应用技术学院 | Reactive antimicrobial additive and preparation method thereof |
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