CN109876158A - Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug - Google Patents
Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug Download PDFInfo
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- CN109876158A CN109876158A CN201910186576.4A CN201910186576A CN109876158A CN 109876158 A CN109876158 A CN 109876158A CN 201910186576 A CN201910186576 A CN 201910186576A CN 109876158 A CN109876158 A CN 109876158A
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Abstract
Application the present invention relates to vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug.The present invention sprays Lushi's iodine solution in upper digestive tract Endoscopy, takes vitamin c solution.The present invention overcomes the defects that past Endoscopy sprinkling Lushi's iodine solution has strong impulse and toxicity to oesophagus and gastric mucosa.Vitamin c solution of the present invention can be relieved upper digestive tract Endoscopy iodine staining subject's mucosal irritation symptom, and patient is made more to be easily accepted by dye endoscopy, mitigate patient suffering.
Description
Technical field
The present invention relates to pharmaceutical technology field, in particular to vitamin C pierces mucous membrane as elimination upper digestive tract iodine staining
Swash the application of drug.
Background technique
Before making the present invention, Endoscopy is the diagnosis common auxiliary examination method of tumor in upper digestive tract, is clinically commonly used
Endolumenal local sprays 2% Lushi's iodine solution and dyes to suspicious lesions mucous membrane.Contain free iodine and iodine in Lushi's iodine solution
Change potassium, be both strong oxidizer, there is strong impulse and toxicity to oesophagus and gastric mucosa, therefore dye in Endoscopy
In the process with inspection after, patient will appear burn feeling and oesophagismus after different degrees of breastbone, and serious person can lead to
The lesions such as mucosal erosion, ulcer, bleeding or even cardiopulmonary arrest, which greatly limits the universal of Endoscopy,
Increase the pain of dye endoscopy.
Currently, clinically using vitamin C as a kind of nutritional supplement, and can be used for scurvy, chronic iron poisoning, special hair
The treatment of property methemoglobinemia etc..
Summary of the invention
The object of the invention is that overcoming drawbacks described above, vitamin C is developed as elimination upper digestive tract iodine staining to viscous
The application of film stimulating drug.
The technical scheme is that
Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug, it is characterised in that: in upper digestion
Road Endoscopy sprays Lushi's iodine solution, takes vitamin c solution.
The Vitamin C content is 1-4% vitamin C.
The Vitamin C content is 2% vitamin C.
Advantages of the present invention and effect are:
1. sprinkling vitamin c solution has endolumenal local iodine staining significant compared with not spraying vitamin c solution
Fading effect.
2. being sprayed in vitamin c solution and in iodine staining patient gastroscopy procedures compared with not spraying vitamin c solution
And check terminate half an hour it is less there is iodine irritation, there are slight iodine irritation patients in minority, can alleviate quickly.
3. spraying in vitamin c solution compared with not spraying vitamin c solution and adverse events occurring in iodine staining patient
Possibility is lower, and severity is lighter.
Vitamin c solution can be relieved upper digestive tract Endoscopy iodine staining subject's mucosal irritation symptom, be easier to patient
Receive dye endoscopy, mitigates patient suffering.
Detailed description of the invention
Fig. 1 --- in vitamin C of the present invention and Lushi's iodine staining effect diagram, left figure are endolumenal local spray
Scheme after spilling 2% Lushi's iodine solution of 10ml, right figure be 2% vitamin c solution of 20ml in and iodine staining element effect picture.
Fig. 2 --- zoopery figure of the present invention；Wherein, A substantially schemes for mucous membrane of esophagus before Lu Ge Shi iodine staining, from left to right
Esophageal tissue is belonging respectively to normal saline flushing group, in sodium thiosulfate and in group, vitamin C and group；B is sprinkling Lu Ge Shi iodine
Dyeing liquor figure, it is seen that 3 pieces of esophageal tissues are dyed to brown；C is that oesophagus iodine dye figure is removed using different disposal method, wherein left
Normal saline flushing passes through in side esophageal tissue, and discovery still remains obvious brown, and intermediate esophageal tissue is using in sodium thiosulfate
It is contaminated with iodine, sodium thiosulfate belongs to strong reducing property chemical reagent, though iodine dye can be neutralized, is easy to not as good as vitamin C in clinic
It obtains and safety, right side esophageal tissue is to contaminate using in 2% vitamin C with iodine, it is seen that it is colourless that brown iodine dye takes off completely；D is
Esophageal tissue after iodine is contaminated and by distinct methods removing iodine dye is through 4% paraformaldehyde soaked overnight, and paraffin embedding HE contaminates
Color, as a result, it has been found that vitamin C not will cause Esophageal mucosa injury and inflammation.
Specific embodiment
Technical thought of the invention:
Vitamin C is microelement important in human body, and a variety of important biomolecule chemical reactions in participant's body are able to maintain
The integrality of human body cell and vascular stroma.Vitamin C is a kind of organic monoacid, is a kind of natural reducing agent, is had excellent
Antioxidation.The present invention will utilize this characteristic of vitamin C.Make Lushi's iodine solution main component iodine using vitamin c solution
Redox reaction has occurred in simple substance, so that eliminating Lushi's iodine solution has strong impulse and poison to oesophagus and gastric mucosa
Property.
The present invention is specifically described below.
After upper digestive tract Endoscopy sprays Lushi's iodine solution and completes to the observation at suspicious lesions position, continue to spray
Vitamin c solution.Vitamin C content is 1-4% vitamin C, and vitamin C optimum content is 2% vitamin C, can be made into solution
Sprinkling.
Its mechanism is:
Redox reaction has occurred in vitamin c solution and Lushi's iodine solution main component elemental iodine, and reaction equation is such as
Under:
C6H8O6(Vit C, ascorbic acid)+I2=C6H6O6(hydroascorbic acid)+2HI
Currently, clinically adult common vitamin C oral dose is 200mg tid, i.e. daily intake 600mg, maximum
Dosage is injected intravenously up to 3g/d.Ascorbic oral median lethal dose (LD50) be 11.9g/kg, take orally the scope of application it is wide and
Safety.The present invention is sprayed at using 2% vitamin c solution of 20ml at Lushi's iodine iodine dye, is equal to once oral 400mg dimension
Raw element C, belongs to clinical common oral dose, and safety is good.
As it can be seen that the vitamin c solution of 2% concentration is as a kind of natural reducing agent, and does not damage gastrointestinal mucosal, have latent
Be applied to Endoscopy in and Lushi's iodine staining prospect.
Fig. 1 be 2% vitamin c solution of 20ml in and 2% Lushi's iodine staining effect of 10ml.Wherein, left figure is under scope
After 2% Lushi's iodine solution of localized pulverization 10ml, right figure be 2% vitamin c solution of 20ml in and iodine staining element effect.
It is as shown in Figure 2:
Overall length oesophagus is taken rapidly after 36 monthly age Yorkshires euthanasia, is divided into 3 parts.4 DEG C of pre-cooling PBS buffer solution drifts
It washes, removes esophageal contents and blood stains.2%, which is uniformly sprayed, in mucous membrane of esophagus face now matches Lushi's iodine dye liquor, after 2 minutes, respectively at
Mucous membrane of esophagus face sprinkling same amount of normal saline, 5% hypo solution, 2% vitamin c solution simultaneously observe each group colour fading effect
Fruit.Oesophagus after processing is immersed in 4% paraformaldehyde overnight, embedding paraffin section is taken out and does HE dyeing, is further looked at
2% vitamin c solution has not damaged and whether acute inflammatory reaction occurs to mucous membrane of esophagus integrality.NS: physiological saline；STS:
Hypo solution；VCS: vitamin c solution.A figure: each group mucous membrane of esophagus is substantially seen before iodine contaminates；B figure: each group is eaten after iodine dye
Pipe mucous membrane is substantially seen；C figure: each group mucous membrane of esophagus is respectively adopted physiological saline, hypo solution, vitamin c solution and rinses
Discoloration afterwards；D figure: each group mucous membrane of esophagus HE staining conditions (× 200 times).
It proves in vitamin C and Lu Ge Shi iodine staining has safety and validity.
Table 1 is various concentration vitamin c solution and different configuration proportion Lushi iodine solution mixing rear decolorings required times
Note: this experiment is respectively by free iodine: potassium iodide is made into Lu of 10ml different proportion in 1: 1,1: 1.5,1: 2 ratio
Ge Shi iodine solution, wherein be current clinically used Lushi iodine solution configuration proportion at 1: 2.We prepare vitamin C in physiology
In salt water, it is mixed into the vitamin c solution of 0%, 1%, 2%, 4% different proportion of 20ml, by Lu Ge Shi of 10ml different proportion
Iodine solution is mixed with the vitamin c solution of 20ml different proportion, as a result, it has been found that cannot make in 0% vitamin c solution 5min time
Lu's Ge Shi iodine solution brown is faded, and 1%-4% vitamin c solution can make iodine solution fade, and 2% vitamin c solution is in 5 seconds
It is colourless that the brown of iodine solution can be made, which to take off,.It can be seen that 1%-4% vitamin C can neutralize iodine dye, wherein 2% vitamin c solution is most
Good concentration.
Claims (3)
1. application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug, it is characterised in that: in upper digestive tract
Endoscopy sprays Lushi's iodine solution, takes vitamin c solution.
2. being answered as upper digestive tract iodine staining is eliminated mucosal irritation drug according to vitamin C as stated in claim 1
With, it is characterised in that: the Vitamin C content is 1-4% vitamin C.
3. being answered as upper digestive tract iodine staining is eliminated mucosal irritation drug according to vitamin C described in claim requirement 2
With, it is characterised in that: the Vitamin C content is 2% vitamin C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910186576.4A CN109876158A (en) | 2019-03-12 | 2019-03-12 | Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910186576.4A CN109876158A (en) | 2019-03-12 | 2019-03-12 | Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug |
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| CN109876158A true CN109876158A (en) | 2019-06-14 |
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| CN201910186576.4A Pending CN109876158A (en) | 2019-03-12 | 2019-03-12 | Application of the vitamin C as elimination upper digestive tract iodine staining to mucosal irritation drug |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201190A (en) * | 2019-06-27 | 2019-09-06 | 施瑞华 | A kind of coloring agent and preparation method thereof for cancer of the esophagus early diagnosis |
| CN111346238A (en) * | 2020-01-21 | 2020-06-30 | 金多晨 | Kit for esophageal mucosa staining |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623434A (en) * | 2013-12-06 | 2014-03-12 | 江苏省人民医院 | Compound iodine staining diagnostic kit set for esophageal mucosa |
| CN105396148A (en) * | 2015-11-26 | 2016-03-16 | 江苏诚品生物科技有限公司 | Esophageal-mucosa staining combination set |
-
2019
- 2019-03-12 CN CN201910186576.4A patent/CN109876158A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623434A (en) * | 2013-12-06 | 2014-03-12 | 江苏省人民医院 | Compound iodine staining diagnostic kit set for esophageal mucosa |
| CN105396148A (en) * | 2015-11-26 | 2016-03-16 | 江苏诚品生物科技有限公司 | Esophageal-mucosa staining combination set |
Non-Patent Citations (5)
| Title |
|---|
| SUDHA J. DEVAKI等: "Vitamin C: Sources, Functions, Sensing and Analysis", 《INTECHOPEN》 * |
| 林明环等: "维生素C去除医用碘类污染", 《健康必读》 * |
| 王坤等: "中西医结合治疗鼻咽癌放疗后咽炎疗效观察 ", 《中国中西医结合耳鼻咽喉科杂志》 * |
| 荣雪萍: "维生素C溶液用于眼部冲洗脱碘", 《中国冶金工业医学杂志》 * |
| 莫玉芳等: "复方碘滴鼻液的制备及临床应用 ", 《中国医院药学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201190A (en) * | 2019-06-27 | 2019-09-06 | 施瑞华 | A kind of coloring agent and preparation method thereof for cancer of the esophagus early diagnosis |
| CN110201190B (en) * | 2019-06-27 | 2021-12-14 | 施瑞华 | Coloring agent for early diagnosis of esophageal cancer and preparation method thereof |
| CN111346238A (en) * | 2020-01-21 | 2020-06-30 | 金多晨 | Kit for esophageal mucosa staining |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190614 |
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| RJ01 | Rejection of invention patent application after publication |