CN109872804A - A kind of automatic radiotherapy planning system and its application method - Google Patents

A kind of automatic radiotherapy planning system and its application method Download PDF

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Publication number
CN109872804A
CN109872804A CN201910106475.1A CN201910106475A CN109872804A CN 109872804 A CN109872804 A CN 109872804A CN 201910106475 A CN201910106475 A CN 201910106475A CN 109872804 A CN109872804 A CN 109872804A
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radiotherapy planning
radiotherapy
present image
current
planning
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CN109872804B (en
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李宝生
马长升
朱健
黄伟
李洪升
梁月强
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Zhangjiagang Medical Instrument Co Ltd
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Shanghai Satifike Medical Apparatus And Instruments Co Ltd
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Abstract

The invention discloses a kind of automatic radiotherapy planning systems, and the system comprises have the data reception module for receiving patient data, the data server for storing patient medical data, the automatic automatic radiotherapy planning module for modifying radiotherapy planning and the data transmission blocks for sending radiotherapy planning.Automatic radiotherapy planning system user provided by the invention only needs to upload with reference to CT image, with reference to delineating and refer to radiotherapy planning, automatic radiotherapy planning system can automatically generate the radiotherapy planning after secondary positioning, accuracy rate is high, the efficiency for improving the secondary formulation of radiotherapy planning greatly reduces doctor's workload.

Description

A kind of automatic radiotherapy planning system and its application method
Technical field
The invention belongs to medical radioactive instrument field more particularly to a kind of automatic radiotherapy planning systems and its application method.
Background technique
One course for the treatment of of radiotherapy usually requires one month or the longer time, first according to the initial fixed of patient before radiotherapy starts Bit image generates radiotherapy planning.But the location and shape of patient's tumour would generally change in entire Patients During Radiotherapy, this The deviation for occurring radiological dose in Patients During Radiotherapy is resulted in, radiotherapeutic effect is not only influenced, more likely will affect the normal of patient Organ-tissue leads to complication.
In order to solve this problem, it usually needs to carry out patient after radiotherapy starts a period of time in the prior art Reorientation obtains the new image of patient by reorientation, and doctor re-starts according to new images delineates and formulate radiotherapy planning, but It is that this process needs to consume the very big workload of doctor.
Summary of the invention
In order to solve the above-mentioned technical problem.The present invention proposes a kind of automatic radiotherapy planning system and its application method, utilizes With reference to radiotherapy planning, the plan after relocating is automatically generated, the workload of doctor is greatly reduced.Specific technical solution is as follows.
A kind of automatic radiotherapy planning system, the system comprises data reception module, data server, automatic radiotherapy plannings Module, data transmission blocks.
Preferably
The data reception module for receiving patient with reference to radiotherapy data and present image, and is saved into data Server;Wherein,
It is described with reference to radiotherapy data include reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;It is described current Image is the image newly obtained after patient relocates;
The data server, for storing all medical datas of patient;
The automatic radiotherapy planning module, after data reception module receives present image automatically according to patient's name and ID goes on data server to inquire and obtain the reference radiotherapy data of the patient;And three are carried out to reference picture and present image Image registration is tieed up, 3 D deformation vector field of the present image relative to reference picture is obtained;And according to the 3 D deformation vector , it will be mapped on present image with reference to delineating, acquisition is currently delineated, and the equal centers in reference radiotherapy planning are mapped to On present image, the equal centers of current radiotherapy planning are obtained;Further according to the 3 D deformation vector in the region of interest of setting , it modifies to reference radiotherapy planning and generates current radiotherapy planning;It is calculated separately again with reference to radiotherapy planning and current radiotherapy meter It draws in the dosage distribution currently delineated, counts the dose volume data of each organ;Finally, by present image, currently delineate, Current radiotherapy planning is saved in data server;
The data transmission blocks, the current radiotherapy planning for confirming physics teacher are sent to scheduling software and carry out scheduling Or it is sent to other radiotherapy servers and carries out scheduling and treatment.
Preferably, the automatic radiotherapy planning module includes display and confirmation module;
The display and confirmation module can make physics teacher check and confirm whether currently delineating for given patient be accurate, Check and confirm whether current radiotherapy planning correct, comparison with reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning current It delineates, current radiotherapy planning is in the dosage and dose volume histogram currently delineated.
Preferably, reference picture, with reference to the figure once positioned before delineating, being respectively referred to reference to radiotherapy planning and reference dose As, delineate, radiotherapy planning and dosage.
Preferably, the automatic radiotherapy planning module, which modifies to reference radiotherapy planning, generates the tool of current radiotherapy planning Body step are as follows:
(1) the 3 D deformation vector field according to present image relative to reference picture, present image is generated as and is referred to The identical blending image of image coverage area;
(2) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning The two dimension deformation vector field of transmitted intensity on direction;
(3) two dimension in corresponding beam direction is penetrated according to the two dimension deformation vector field of transmitted intensity in each beam direction Line intensity distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated;
(4) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door movement number are generated According to get arrive new radiotherapy planning.
Preferably, the region of interest in the step (2) includes target area and jeopardizes organ.
Preferably, in the step (2) target area and jeopardize organ determine it is described with reference to each beam side in radiotherapy planning Weight when the two dimension deformation vector field of upward transmitted intensity is different.
Application method based on above-mentioned automatic radiotherapy planning system, which comprises
(1) image for newly obtaining patient, i.e. present image upload to automatic radiotherapy planning system;
(2) the automatic radiotherapy planning module inquires on data server and obtains the trouble according to patient's name and ID The reference radiotherapy data of person;It is described with reference to radiotherapy data include reference picture, with reference to delineate, with reference to radiotherapy planning and with reference to agent Amount;
(3) the automatic radiotherapy planning module carries out 3-D image registration to reference picture and present image, obtains current 3 D deformation vector field of the image relative to reference picture;
(4) the automatic radiotherapy planning module will be mapped to current figure with reference to delineating according to the 3 D deformation vector field As upper, obtain currently delineate, by reference radiotherapy planning etc. centers be mapped on present image, obtain current radiotherapy meter The equal centers drawn;
(5) the automatic radiotherapy planning module puts reference according to the 3 D deformation vector field in the region of interest of setting Treatment plan, which is modified, generates current radiotherapy planning;
(6) the automatic radiotherapy planning module, which is calculated separately, delineates with reference to radiotherapy planning and current radiotherapy planning currently Dosage distribution, count the dose volume data of each organ;
(7) the automatic radiotherapy planning module is delineated by present image, currently, current radiotherapy planning is saved in data service Device;
(8) currently delineating with whether current radiotherapy planning is accurate for the patient is checked and confirmed to physics teacher given patient, Comparison with reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning currently delineate, current radiotherapy planning is currently being delineated Dosage and dose volume histogram;
(9) if physics teacher confirms that current radiotherapy planning is correct, the current radiotherapy planning that will confirm that be sent to scheduling software into Row scheduling;
(10) it if physics teacher does not receive current radiotherapy planning, is currently delineated or re-optimization radiotherapy meter according to reason modification It draws, until obtaining acceptable current radiotherapy planning, confirms current radiotherapy planning, the current radiotherapy planning that will confirm that is sent to row Journey software carries out scheduling.
Preferably, it modifies in the step (5) to reference radiotherapy planning and generates the specific steps of current radiotherapy planning Are as follows:
(5.1) the 3 D deformation vector field according to present image relative to reference picture, present image is generated as and is joined Examine the identical blending image of image coverage area;
(5.2) it is determined in the reference radiotherapy planning according to the 3 D deformation vector field in the region of interest of setting and is each penetrated The two dimension deformation vector field of the upper transmitted intensity of Shu Fangxiang;
(5.3) according to the two dimension deformation vector field of transmitted intensity in each beam direction to the two dimension in corresponding beam direction Ray density distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated;
(5.4) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and the movement of tungsten door are generated Data to get arrive new radiotherapy planning.
Preferably, the region of interest in the step (5.2) includes target area and jeopardizes organ.
Preferably, in the step (5.2) target area and jeopardize organ determine it is described with reference to each beam in radiotherapy planning Weight is different when the two dimension deformation vector field of transmitted intensity on direction.
Preferably, reference picture, with reference to the figure once positioned before delineating, being respectively referred to reference to radiotherapy planning and reference dose As, delineate, radiotherapy planning and dosage.
Preferably, the step is carried out by the display of the automatic radiotherapy planning module and confirmation module, described automatic Radiotherapy planning module reads related data from data server.
A kind of automatic radiotherapy planning apparatus, described device include:
At least one processor;And
Memory is stored with executable instruction on the memory, and the executable instruction is by least one described processing Device executes, and described device is caused to realize following method:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include with reference to radiotherapy data Reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains three-dimensional of the present image relative to reference picture Deform vector field;It according to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, incited somebody to action It is mapped on present image with reference to the equal centers in radiotherapy planning, obtains the equal centers of current radiotherapy planning;Root again According to the 3 D deformation vector field in the region of interest of setting, modifies to reference radiotherapy planning and generate current radiotherapy planning;Again It calculates separately with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dosage body of each organ Volume data;And it saves present image, currently delineate, current radiotherapy planning.
Preferably, described pair of reference radiotherapy planning, which is modified, generates the specific steps of current radiotherapy planning are as follows:
(1) according to the 3 D deformation vector field, present image is generated as melt identical with reference picture coverage area Close image;
(2) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning The two dimension deformation vector field of transmitted intensity on direction;
(3) two dimension in corresponding beam direction is penetrated according to the two dimension deformation vector field of transmitted intensity in each beam direction Line intensity distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated;
(4) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door movement number are generated According to get arrive new radiotherapy planning.
Preferably, the region of interest in the step (2) includes target area and jeopardizes organ.
Preferably, target area described in the step (2) and jeopardize organ determine it is described with reference to each penetrating in radiotherapy planning Weight is different when the two dimension deformation vector field of the upper transmitted intensity of Shu Fangxiang.
A kind of computer-readable storage media, including executable instruction, when described instruction is executed by least one processor, Realize following method:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include with reference to radiotherapy data Reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains three-dimensional of the present image relative to reference picture Deform vector field;It according to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, incited somebody to action It is mapped on present image with reference to the equal centers in radiotherapy planning, obtains the equal centers of current radiotherapy planning;Root again According to the 3 D deformation vector field in the region of interest of setting, modifies to reference radiotherapy planning and generate current radiotherapy planning;Again It calculates separately with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dosage body of each organ Volume data;And it saves present image, currently delineate, current radiotherapy planning.
Preferably, described pair of reference radiotherapy planning, which is modified, generates the specific steps of current radiotherapy planning are as follows:
(1) according to the 3 D deformation vector field, present image is generated as melt identical with reference picture coverage area Close image;
(2) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning The two dimension deformation vector field of transmitted intensity on direction;
(3) two dimension in corresponding beam direction is penetrated according to the two dimension deformation vector field of transmitted intensity in each beam direction Line intensity distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated;
(4) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door movement number are generated According to get arrive new radiotherapy planning.
Preferably, the region of interest in the step (2) includes target area and jeopardizes organ.
Preferably, target area described in the step (2) and jeopardize organ determine it is described with reference to each penetrating in radiotherapy planning Weight is different when the two dimension deformation vector field of the upper transmitted intensity of Shu Fangxiang.
By using the combination of one or more technical solution in the above summary of the invention, the present invention at least has below The utility model has the advantages that the present invention is based on 3-D image registration technique, user only needs to upload reference picture, with reference to delineating and refer to radiotherapy Plan, automatic radiotherapy planning system can automatically generate the radiotherapy planning after reorientation, and accuracy rate is high, improves radiotherapy planning two The efficiency of secondary formulation greatly reduces doctor's workload;Artificial intelligence technology is applied in radiotherapy planning formulation, doctor is assisted Carry out it is secondary delineate with secondary formulation, realize the specified regulation and standardization of radiotherapy planning and homogenize.
It should be understood that above general description and following detailed description be only it is exemplary and explanatory, not The application can be limited.
Detailed description of the invention
In order to illustrate more clearly of the embodiment of the present disclosure or technical solution in the prior art, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Disclosed some embodiments for those of ordinary skill in the art without creative efforts, can be with Other attached drawings are obtained according to these figures.
Fig. 1 is a kind of example system configuration schematic diagram of automatic radiotherapy planning system
Specific embodiment
Below in conjunction with drawings and examples, the present invention is described in further detail.Aforementioned and other mesh of the invention , features, aspects and advantages will be apparent, to enable those skilled in the art's refer to the instruction text real accordingly It applies.
It is understood that specific embodiment described herein is used only for explaining the present invention, rather than to of the invention It limits.It also should be noted that only the parts related to the present invention are shown for ease of description, in attached drawing and it is not all Structure.It should be mentioned that some exemplary embodiments are described as making before exemplary embodiment is discussed in greater detail The processing or method described for flow chart.Although operations (or step) are described as the processing of sequence by flow chart, its In many operations can be implemented concurrently, concomitantly or simultaneously.In addition, the sequence of operations can be pacified again Row.The processing can be terminated when its operations are completed, it is also possible to have the additional step being not included in attached drawing.Institute Stating processing can cope in method, function, regulation, subroutine, subprogram etc..
It is only to be not intended to be limiting the application merely for for the purpose of describing particular embodiments in term used in this application. It is also intended in the application and the "an" of singular used in the attached claims, " described " and "the" including majority Form, unless the context clearly indicates other meaning.It is also understood that term "and/or" used herein refers to and wraps It may be combined containing one or more associated any or all of project listed.
Embodiment 1
A kind of automatic radiotherapy planning system 100, the system comprises data reception module 101, data server 102, from Dynamic radiotherapy planning module 103 and data transmission blocks 104.
The data reception module 101, for receiving patient with reference to the figure newly obtained after radiotherapy data and patient's reorientation As (that is, present image), and it is saved into data server 102;Wherein,
The data server 102, for storing all medical datas of patient;
The automatic radiotherapy planning module 103, automatically according to patient after data reception module 101 receives present image Name and ID go on data server 102 to inquire and obtain the reference radiotherapy data of the patient;And to reference picture and currently Image carries out 3-D image registration, obtains 3 D deformation vector field of the present image relative to reference picture;And according to described three Dimension deformation vector field, will be mapped on present image with reference to delineating, and acquisition is currently delineated, by the equal centers in reference radiotherapy planning Position is mapped on present image, obtains the equal centers of current radiotherapy planning;Further according to three in the region of interest of setting Dimension deformation vector field, modifies to reference radiotherapy planning and generates current radiotherapy planning;Calculate separately again with reference to radiotherapy planning and Current radiotherapy planning counts the dose volume data of each organ in the dosage distribution currently delineated;Finally, will currently scheme As, currently delineate, current radiotherapy planning is saved in data server 102;
The data transmission blocks 104, the current radiotherapy planning for confirming physics teacher are sent to the progress of scheduling software Scheduling is sent to other radiotherapy servers progress schedulings and treatment.
Preferably, it is described with reference to radiotherapy data include but is not limited to reference picture, with reference to delineate, with reference to radiotherapy planning and ginseng Examine dosage;Wherein, reference picture, with reference to the image once positioned before delineating, being respectively referred to reference to radiotherapy planning and reference dose, hook Picture, radiotherapy planning and dosage.
Preferably, the automatic radiotherapy planning module 103 includes display and confirmation module.
The display and confirmation module can make physics teacher check and confirm whether currently delineating for given patient be accurate, Check and confirm whether current radiotherapy planning correct, comparison with reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning current It delineates, current radiotherapy planning is in the dosage and dose volume histogram currently delineated.
Embodiment 2
A kind of automatic radiotherapy planning optimization method based on the automatic radiotherapy planning system 100 in embodiment one, specifically:
(1) image for newly obtaining patient, i.e. present image upload to automatic radiotherapy planning system 100;
(2) the automatic radiotherapy planning module 103 is inquired and is obtained on data server 102 according to patient's name and ID The reference radiotherapy data of the patient;It is described with reference to radiotherapy data include reference picture, with reference to delineate, with reference to radiotherapy planning and ginseng Examine dosage;
Preferably, it is described with reference to radiotherapy data include but is not limited to reference picture, with reference to delineate, with reference to radiotherapy planning and ginseng Examine dosage;Wherein, reference picture, with reference to the image once positioned before delineating, being respectively referred to reference to radiotherapy planning and reference dose, hook Picture, radiotherapy planning and dosage;
(3) the automatic radiotherapy planning module 103 carries out 3-D image registration to reference picture and present image, and acquisition is worked as 3 D deformation vector field of the preceding image relative to reference picture;
(4) the automatic radiotherapy planning module 103 will be mapped to currently according to the 3 D deformation vector field with reference to delineating On image, obtain currently delineate, by reference radiotherapy planning etc. centers be mapped on present image, obtain current radiotherapy The equal centers of plan;
(5) the automatic radiotherapy planning module 103 is according to the 3 D deformation vector field in the region of interest of setting, to reference Radiotherapy planning is modified, and current radiotherapy planning is generated;
(6) the automatic radiotherapy planning module 103, which is calculated separately, hooks with reference to radiotherapy planning and current radiotherapy planning currently The dosage distribution drawn, counts the dose volume data of each organ;
(7) the automatic radiotherapy planning module 103 is delineated by present image, currently, current radiotherapy planning is saved in data Server 102;
(8) currently delineating with whether current radiotherapy planning is accurate for the patient is checked and confirmed to physics teacher given patient, Comparison with reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning currently delineate, current radiotherapy planning is currently being delineated Dosage and dose volume histogram;
Preferably, step (8) is carried out by the display and confirmation module, and the automatic radiotherapy planning module 103 is from number Related data is read according to server 102;
(9) if physics teacher confirms that current radiotherapy planning is correct, the current radiotherapy planning that will confirm that be sent to scheduling software into Row scheduling;
(10) it if physics teacher does not receive current radiotherapy planning, is currently delineated or re-optimization radiotherapy meter according to reason modification It draws, until obtaining acceptable current radiotherapy planning, confirms current radiotherapy planning, the current radiotherapy planning that will confirm that is sent to row Journey software carries out scheduling.
Preferably, the step (2) can criticize automatically to step (7) in the case where not display interface is without manual intervention Amount carries out.
Preferably, the 3-D image registration in the step (3), the calculating in step (6) are with reference to radiotherapy planning and currently Radiotherapy planning carries out parallel computation in the automatic radiotherapy planning module 103 in the dosage distribution currently delineated.
Embodiment 3
On the basis of the above embodiments, the present invention further discloses a kind of automatic radiotherapy planning apparatus, the dress It sets and includes:
At least one processor;And
Memory is stored with executable instruction on the memory, and the executable instruction is by least one described processing Device executes, and described device is caused to realize following method:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include with reference to radiotherapy data Reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains three-dimensional of the present image relative to reference picture Deform vector field;It according to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, incited somebody to action It is mapped on present image with reference to the equal centers in radiotherapy planning, obtains the equal centers of current radiotherapy planning;Root again According to the 3 D deformation vector field in the region of interest of setting, modifies to reference radiotherapy planning and generate current radiotherapy planning;Again It calculates separately with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dosage body of each organ Volume data;And it saves present image, currently delineate, current radiotherapy planning.
The invention also discloses a kind of computer-readable storage medias, including executable instruction, and described instruction is by least one When a processor executes, following method is realized:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include with reference to radiotherapy data Reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains three-dimensional of the present image relative to reference picture Deform vector field;It according to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, incited somebody to action It is mapped on present image with reference to the equal centers in radiotherapy planning, obtains the equal centers of current radiotherapy planning;Root again According to the 3 D deformation vector field in the region of interest of setting, modifies to reference radiotherapy planning and generate current radiotherapy planning;Again It calculates separately with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dosage body of each organ Volume data;And it saves present image, currently delineate, current radiotherapy planning.
For the embodiment of device and storage medium, since it is substantially similar to system embodiment, so description It is fairly simple, related place illustrates referring to the part of system embodiment.
Embodiment 4
On the basis of embodiment 1-3, modifies to reference radiotherapy planning and generate the specific steps of current radiotherapy planning Are as follows:
(1) obtain reference picture, with reference to delineate, with reference to radiotherapy planning, present image.
(2) image registration is carried out to present image and reference picture, generates corresponding three-dimensional and deforms vector field.
(3) it according to the 3 D deformation vector field, generates blending image identical with reference picture coverage area and retouches It states target area and the online of organ contours delineates (that is, currently delineating);
(4) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning The two dimension deformation vector field of transmitted intensity on direction.
(5) two dimension in corresponding beam direction is penetrated according to the two dimension deformation vector field of transmitted intensity in each beam direction Line intensity distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated.
(6) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door movement number are generated According to producing new radiotherapy planning.
Preferably, the image registration in the step (2) includes first latter two steps: (2.1) image rigid registration; (2.2) anamorphose is registrated.
Preferably, the reference is determined according to the 3 D deformation vector field in the region of interest of setting in the step (4) It can be different region of interest in radiotherapy planning in each beam direction during the two dimension deformation vector field of transmitted intensity Different weights is set.
Preferably, the region of interest is target area;Further, the region of interest further includes important jeopardizing organ.
Preferably, during generating blending image in the step (3), if the coverage area of target image is less than reference Image, then in the overlapping region of reference picture and target image, blending image by reference picture to target image deformable registration It obtains;Region other than target image is obtained by the rigid registration of reference picture and target image.
Preferably, it while blending image is generated in the step (3) and is currently delineated, needs according to the 3 D deformation Equal centers in reference radiotherapy planning are mapped on target image by vector field, to obtain the equal centers of new radiotherapy planning Position.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited In specific details.

Claims (10)

1. a kind of automatic radiotherapy planning system, which is characterized in that the system comprises data reception module, data server, from Dynamic radiotherapy planning module, data transmission blocks.
2. a kind of automatic radiotherapy planning system according to claim 1, which is characterized in that
The data reception module for receiving patient with reference to radiotherapy data and present image, and is saved into data service Device;Wherein,
It is described with reference to radiotherapy data include reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;The present image For the image newly obtained after patient's reorientation;
The data server, for storing all medical datas of patient;
The automatic radiotherapy planning module, goes after data reception module receives present image automatically according to patient's name and ID The reference radiotherapy data of the patient are inquired and obtained on data server;And three-dimensional figure is carried out to reference picture and present image As registration, 3 D deformation vector field of the present image relative to reference picture is obtained;It, will and according to the 3 D deformation vector field It is mapped on present image with reference to delineating, acquisition is currently delineated, and the equal centers in reference radiotherapy planning are mapped to currently On image, the equal centers of current radiotherapy planning are obtained;It is right further according to the 3 D deformation vector field in the region of interest of setting It modifies with reference to radiotherapy planning and generates current radiotherapy planning;It calculates separately and is working as with reference to radiotherapy planning and current radiotherapy planning again Before delineate dosage distribution, count the dose volume data of each organ;Finally, by present image, currently delineating, currently putting Treatment plan is saved in data server;
The data transmission blocks, the current radiotherapy planning for confirming physics teacher are sent to scheduling software and carry out scheduling or hair It is sent to other radiotherapy servers and carries out scheduling and treatment.
3. a kind of automatic radiotherapy planning system according to claim 2, which is characterized in that the automatic radiotherapy planning module Including display and confirmation module;
The display and confirmation module can make physics teacher check and confirm whether currently delineating for given patient be accurate, checks With confirm whether current radiotherapy planning correct, comparison with reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning currently delineate, Current radiotherapy planning is in the dosage and dose volume histogram currently delineated.
4. a kind of automatic radiotherapy planning system according to claim 2, which is characterized in that reference picture, with reference to delineating, join Examine radiotherapy planning and reference dose respectively refer to before once position image, delineate, radiotherapy planning and dosage.
5. a kind of automatic radiotherapy planning system according to claim 2, which is characterized in that the automatic radiotherapy planning module It modifies to reference radiotherapy planning and generates the specific steps of current radiotherapy planning are as follows:
(1) present image is generated as and reference picture by the 3 D deformation vector field according to present image relative to reference picture The identical blending image of coverage area;
(2) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam direction in radiotherapy planning The two dimension deformation vector field of upper transmitted intensity;
(3) the two dimension deformation vector field according to transmitted intensity in each beam direction is strong to the two-dimentional ray in corresponding beam direction Degree distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated;
(4) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door exercise data are generated, i.e., Obtain new radiotherapy planning.
6. a kind of automatic radiotherapy planning system according to claim 5, which is characterized in that the sense in the step (2) is emerging Interesting area includes target area and jeopardizes organ.
7. a kind of automatic radiotherapy planning system according to claim 6, which is characterized in that in the step (2) target area and Jeopardize power of the organ when determining that the two dimension with reference to transmitted intensity in beam direction each in radiotherapy planning deforms vector field Value is different.
8. based on a kind of application method of automatic radiotherapy planning system described in claim 1, which is characterized in that the method packet It includes:
(1) image for newly obtaining patient, i.e. present image upload to automatic radiotherapy planning system;
(2) the automatic radiotherapy planning module inquires on data server and obtains the patient's according to patient's name and ID With reference to radiotherapy data;It is described with reference to radiotherapy data include reference picture, with reference to delineate, with reference to radiotherapy planning and reference dose;
(3) the automatic radiotherapy planning module carries out 3-D image registration to reference picture and present image, obtains present image 3 D deformation vector field relative to reference picture;
(4) the automatic radiotherapy planning module will be mapped on present image according to the 3 D deformation vector field with reference to delineating, Obtain currently delineate, by reference radiotherapy planning etc. centers be mapped on present image, obtain current radiotherapy planning Equal centers;
(5) the automatic radiotherapy planning module is according to the 3 D deformation vector field in the region of interest of setting, to reference radiotherapy meter It draws and modifies, generate current radiotherapy planning;
(6) the automatic radiotherapy planning module is calculated separately with reference to radiotherapy planning and current radiotherapy planning in the agent currently delineated Amount distribution, counts the dose volume data of each organ;
(7) the automatic radiotherapy planning module is delineated by present image, currently, current radiotherapy planning is saved in data server;
(8) physics teacher given patient checks and confirms that the patient's currently delineates the comparison with whether current radiotherapy planning is accurate With reference to radiotherapy planning with reference to delineate, with reference to radiotherapy planning currently delineate, current radiotherapy planning is in the dosage currently delineated And dose volume histogram;
(9) if physics teacher confirms that current radiotherapy planning is correct, the current radiotherapy planning that will confirm that is sent to scheduling software and is arranged Journey;
(10) it if physics teacher does not receive current radiotherapy planning, is currently delineated or re-optimization radiotherapy planning according to reason modification, Until obtaining acceptable current radiotherapy planning, current radiotherapy planning is confirmed, the current radiotherapy planning that will confirm that is sent to scheduling Software carries out scheduling.
9. a kind of automatic radiotherapy planning apparatus, which is characterized in that described device includes:
At least one processor;And
Memory is stored with executable instruction on the memory, and the executable instruction is held by least one described processor Row causes described device to realize following method:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include reference with reference to radiotherapy data Image, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains 3 D deformation of the present image relative to reference picture Vector field;According to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, will be referred to Equal centers in radiotherapy planning are mapped on present image, obtain the equal centers of current radiotherapy planning;Further according to setting 3 D deformation vector field in fixed region of interest, modifies to reference radiotherapy planning and generates current radiotherapy planning;Distinguish again It calculates with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dose volume number of each organ According to;And it saves present image, currently delineate, current radiotherapy planning.
10. a kind of computer-readable storage media, including executable instruction, when described instruction is executed by least one processor, Realize following method:
Obtain the new image of patient, i.e. present image;
According to patient's name and ID inquiry and the reference radiotherapy data for obtaining the patient;It is described to include reference with reference to radiotherapy data Image, with reference to delineate, with reference to radiotherapy planning and reference dose;
3-D image registration is carried out to reference picture and present image, obtains 3 D deformation of the present image relative to reference picture Vector field;According to the 3 D deformation vector field, will be mapped on present image with reference to delineating, acquisition is currently delineated, will be referred to Equal centers in radiotherapy planning are mapped on present image, obtain the equal centers of current radiotherapy planning;Further according to setting 3 D deformation vector field in fixed region of interest, modifies to reference radiotherapy planning and generates current radiotherapy planning;Distinguish again It calculates with reference to radiotherapy planning and current radiotherapy planning in the dosage distribution currently delineated, counts the dose volume number of each organ According to;And it saves present image, currently delineate, current radiotherapy planning.
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