CN109839333A - Sound wave drives particle rotating device - Google Patents
Sound wave drives particle rotating device Download PDFInfo
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- CN109839333A CN109839333A CN201910154359.7A CN201910154359A CN109839333A CN 109839333 A CN109839333 A CN 109839333A CN 201910154359 A CN201910154359 A CN 201910154359A CN 109839333 A CN109839333 A CN 109839333A
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Abstract
The present invention discloses a kind of sound wave driving particle rotating device comprising substrate and sonic generator；Wherein, the groove in Archimedian screw shape is offered on the front of substrate, sonic generator is located at the back side of substrate, and sonic generator is directed at groove；Under the action of torque, particle can drive particle to rotate, avoid to particle or cell damage on the phase singularity at acoustic wavefield center with higher frequency rotation without using Mechanical Contact power；Simultaneously as structure of the invention is simple, at low cost, it is easy to be widely used and promote.
Description
Technical field
The present invention relates to a kind of sound waves to drive particle rotating device.
Background technique
Micro- manipulation technology is since it can accurately capture particle, move, in various fields such as physics,
Extremely important application is suffered from chemistry, biology and pharmacology.Micro- manipulation technology manipulation particle method is mainly divided at present
For two major classes, one type method is to apply contact force using mechanical means in target object, Mechanical Contact power can to particle or
Cell damage；Another kind of method for optical tweezer, magnetic tweezer and electrical method, is grasped using such as magnetic tweezer, optical tweezer technology
Vertical mode is all strongly dependent on the optics for being manipulated particle, magnetics or electrical properties, optical tweezer, magnetic tweezer and electrical method there is
Limitation, and in published acoustic method, there is no not only do not need to by the additional supporting method but also energy of rotating object
Enough methods for stablize rotation to the cell or particle of smaller scale.It can be seen that needing a kind of neither to cause to hurt to particle or cell
Evil, but having can widely used driving particle rotating device.
Summary of the invention
The object of the present invention is to provide a kind of sound waves to drive particle rotating device, solves one in above-mentioned prior art problem
It is a or multiple.
According to an aspect of the invention, there is provided a kind of sound wave drives particle rotating device comprising substrate and sound wave
Generator；Wherein, the groove in Archimedian screw shape is offered on the front of substrate, sonic generator is located at the back of substrate
Face, and sonic generator is directed at groove.
In this way, towards substrate sound wave occurs for sonic generator, sound wave is after through the groove in Archimedian screw shape, sound wave
It is shaped as single order Bezier rotational field；The verifying analytic process of the shaping effect: in the acoustic wavefield shaping effect for inquiring into the substrate
When fruit, groove structure can be considered as to the secondary source of near field acoustic beam shaping.Each circle structure that whole acoustic wavefield is equivalent to groove is made
The superposition of sound field is generated for secondary source.Now provide the formula of origin near zone (R, θ) interior sound field intensity:
Under polar coordinates, parameter R (observation point is at a distance from groove center origin) and parameter θ (angle of observation point) by with
It is observed a little to demarcate, in this formula, A0A constant, r is by groove differential be one by one secondary source when, each secondary
The distance between origin in source and structure.WithIt is the unit vector in the direction R and the direction r, krAnd kzIt is on the direction r respectively
Wave number in (radial direction) and the direction z, radially, the groove structure duplicate period is g, soIt is existing
By the formula of grooveIt substituting into wherein, we only discuss the case where structure rotates counterclockwise now, so
Sign takes just.Formula integral can be obtained along groove:
It is readily seen the form of the tilde unification rank Bezier beam of the acoustic wavefield around groove center origin.Its sound wave
Field is really concentric circles, and has the phase change of 2 π on the minimum point of heart origin along azimuth in the trench.The sound of transmission
The concentric structure of ring by ring is presented in the cross section of wave field, and the acoustic pressure force value of acoustic wavefield center is zero.In substrate
Under shaping, the sound wave field intensity of objective plane has apparent strength distribution, and acoustic wavefield is in concentric loop, and in acoustic wavefield
The heart (i.e. groove center origin) then has a field strength obviously weaker region.In specific application, the particle such as cell
It is put into groove middle position.For particle (such as cell) biggish for acoustical absorptivity, in the effect of acoustic radiation force
It is lower to be bound in the weaker position of sound field, so the weaker area of field strength will be overwhelmed by acoustic wavefield when particle is around the center of circle
Domain is gone, and this region is just in the center of acoustic wavefield (i.e. groove center origin), and has the phase change of 2 π.For having
For the object of acoustical absorptivity, such phase change also means that object can experience the effect of torque.In torque
Under effect, particle can be on the phase singularity at acoustic wavefield center with higher frequency rotation.And the strong ring around phase singularity exists
At this moment it is also capable of providing the effect of constraint, provides condition for the high-frequency stabilization rotation of particle.In this way, without using Mechanical Contact
Power drives particle to rotate, and avoids to particle or cell damage；Simultaneously as structure of the invention is simple, at low cost,
It is easy to be widely used and promote.
In some embodiments, substrate is silicon wafer.
In this way, since silicon has the characteristics that stable chemical performance and is unlikely to deform, so that substrate has more stable shape
State is not susceptible to deform.
It in some embodiments, further include lighting system and imaging system, wherein lighting system is arranged for
The center of groove is irradiated, imaging system is arranged to be directed at the center of groove.
In this way, providing lighting source by using lighting system for the center of groove, while being put using imaging system
Big and observation groove center, can intuitively observe the rotation situation of particle, offer convenience for user.
In some embodiments, lighting system includes mercury lamp, the first lens and object lens, wherein mercury lamp is set to groove
Top, object lens are directed at the center of groove, and the first lens are set between mercury lamp and groove.
In this way, passing through the center of Hg lamp irradiation groove, the light of mercury lamp is pooled to groove by the first lens and object lens
Center, so that brightness is more preferably.
In some embodiments, imaging system includes CCD camera, the first spectroscope, the second lens, the second light splitting
Mirror and eyepiece, wherein the first spectroscopical reflective surface alignment object lens and second spectroscopical entering light face, the setting of the second lens is the
Between one spectroscope and the second spectroscope, CCD camera is directed at second spectroscopical first light splitting surface, and eyepiece is directed at the second spectroscope
The second light splitting surface.In this way, user can both be observed by eyepiece, can also using CCD camera to the revolving speed of particle into
Row observation, just can obtain the information such as rotation angular acceleration, the speed of particle, and then obtain the close of particle in the very short time
The physical parameter informations such as degree, volume, acoustical absorptivity, which is applied to biological cell and analyzed by us, can be to biological cell
Activity and pattern sorted, be used clinically for the auxiliary diagnosis of some diseases.
Detailed description of the invention
Fig. 1 is that the sound wave of one embodiment of the present invention drives the schematic diagram of particle rotating device；
Fig. 2 is the schematic diagram for the substrate that sound wave shown in FIG. 1 drives particle rotating device；
Fig. 3 is the cross section view of substrate shown in Fig. 2.
Drawing reference numeral:
1- substrate, 11- groove, 2- sonic generator, 3- particle
Specific embodiment
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
Fig. 1 to Fig. 3 schematically shows the structure of the sound wave driving particle rotating device of one embodiment of the present invention.
As shown in Figure 1, Figure 2 and Figure 3, sound wave driving particle rotating device includes substrate 1 and sonic generator 2；Wherein,
The groove 11 in Archimedian screw shape is offered on the front of substrate 1, sonic generator 2 is located at the back side of substrate 1, and sound wave
Generator 2 is directed at groove 11.Specifically, in the present embodiment, substrate 1 is silicon wafer, in this way, since silicon has chemical property steady
The characteristics of determining and being unlikely to deform is not susceptible to deform so that substrate 1 has more stable state.In other embodiments,
Suitability adjustment can also be carried out by the material to substrate 1 according to the actual situation；More specifically, the equation of locus of groove 11 are as follows:(± determined by the direction of angular speed), in formula, r0It is a constant, represents helix
Initial radium, and g represents the distance between neighboring spiral.φ is that (φ is the circle of helix to 2m π, m by 0 at azimuth
Number), with the increase of φ, groove 11 is just gradually distance from central point and forms helix.The width of groove 11 is w, depth h, silicon
Piece with a thickness of t.Parameters needs meet some requirements, r0/ g=2/3, r0/ w=2.
In the present embodiment, the concrete type of sonic generator 2 is ultrasonic transducer.Deep silicon etching is used on the substrate 1
Technique etches the groove 11 in Archimedian screw shape.The course of work of the invention: sonic generator 2 occurs towards substrate 1
Sound wave, for sound wave after through the groove 11 in Archimedian screw shape, sound wave is shaped as single order Bezier rotational field；The shaping
The verifying analytic process of effect: when inquiring into the acoustic wavefield shaping effect of the substrate 1,11 structure of groove can be considered as near field acoustic beam
The secondary source of shaping.Each circle structure that whole acoustic wavefield is equivalent to groove 11 generates the superposition of sound field as secondary source.Now give
The formula of origin near zone (R, θ) interior sound field intensity out:
Under polar coordinates, parameter R (observation point is at a distance from 11 center origin of groove) and parameter θ (angle of observation point) quilt
It is observed a little for demarcating, in this formula, A0A constant, r is by 11 differential of groove be one by one secondary source when, it is each
The distance between origin in secondary source and structure.WithIt is the unit vector in the direction R and the direction r, krAnd kzIt is the direction r respectively
Wave number in upper (i.e. the radial direction of groove 11) and the direction z (as shown in Figure 3), radially, the duplicate period of groove 11 is g, institute
WithNow by the formula of groove 11It substitutes into wherein, we only discuss now
The case where structure rotates counterclockwise, so sign takes just.11 pairs of formula integrals can obtain along groove:
It is readily seen the form of the tilde unification rank Bezier beam of the acoustic wavefield around 11 center origin of groove.Its sound
Wave field is really concentric circles, and has the phase change of 2 π along azimuth on the minimum point of 11 center origin of groove.Transmission
The cross section of acoustic wavefield the concentric structure of ring by ring is presented, and the acoustic pressure force value of acoustic wavefield center is zero.In base
Under the shaping of piece 1, the sound wave field intensity of objective plane has apparent strength distribution, and acoustic wavefield is in concentric loop, and in sound wave
Center (i.e. 11 center origin of groove) then have a field strength obviously weaker region.It in specific application, will be for example thin
The particles such as born of the same parents 3 are put into 11 middle position of groove.For particle 3 (such as cell) biggish for acoustical absorptivity, in sound
The weaker position of sound field can be bound under the action of radiant force, so will be by acoustic wavefield pressure when particle 3 is around the center of circle
The weaker region of field strength is gone, and this region is just in the center of acoustic wavefield (i.e. 11 center origin of groove), and has 2 π's
Phase change.For the object with acoustical absorptivity, such phase change also means that object can experience power
The effect of square.Under the action of torque, particle 3 can be on the phase singularity at acoustic wavefield center with higher frequency rotation.And phase
Strong ring around the singular point of position provides condition in the effect for being at this moment also capable of providing constraint for the high-frequency stabilization rotation of particle 3.This
Sample drives particle 3 to rotate without using Mechanical Contact power, avoids to particle 3 or cell damage；Simultaneously as this
The structure of invention is simple, at low cost, is easy to be widely used and promote.
It in the present embodiment, further include lighting system and imaging system, wherein lighting system is arranged for irradiating
The center of groove, imaging system are arranged to be directed at the center of groove.In this way, being the center of groove by using lighting system
Lighting source is provided, while amplifying and observing the center of groove using imaging system, can intuitively observe turning for particle
Emotionally condition offers convenience for user.
In the present embodiment, lighting system includes mercury lamp, the first lens and object lens, wherein mercury lamp is set to the upper of groove
Side, object lens are directed at the center of groove, and the first lens are set between mercury lamp and groove.In this way, by Hg lamp irradiation groove
The heart, the light of mercury lamp is pooled to the center of groove by the first lens and object lens, so that brightness is more preferably.
In the present embodiment, imaging system include CCD camera, the first spectroscope, the second lens, the second spectroscope and
Eyepiece, wherein first spectroscopical reflective surface alignment object lens and second spectroscopical entering light face, the second lens are arranged at first point
Between light microscopic and the second spectroscope, CCD camera is directed at second spectroscopical first light splitting surface, eyepiece alignment second spectroscopical the
Two light splitting surfaces.In this way, being irradiated to the first spectroscope by object lens from the light that the foveal reflex of groove goes out, then pass through first point
It after light microscopic is reflected into the second lens, is irradiated on the second spectroscope again by the optically focused of the second lens, last light passes through second
Spectroscope is delivered separately to eyepiece and CCD camera；In this way, user can both observe by eyepiece, CCD phase can also be utilized
Machine is observed the revolving speed of particle, and the information such as rotation angular acceleration, the speed of particle just can be obtained in the very short time, into
And the physical parameter informations such as the density, volume, acoustical absorptivity of particle are obtained, which is applied to biological cell point by us
Analysis, can activity to biological cell and pattern sort, be expected to be used clinically for the auxiliary diagnosis of some diseases.
Above-described is only one embodiment of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.
Claims (5)
1. sound wave drives particle rotating device, which is characterized in that including substrate and sonic generator；
Wherein, the groove in Archimedian screw shape is offered on the front of the substrate, the sonic generator is located at substrate
The back side, and sonic generator is directed at the groove.
2. sound wave according to claim 1 drives particle rotating device, which is characterized in that the substrate is silicon wafer.
3. sound wave according to claim 1 drives particle rotating device, which is characterized in that further include lighting system and imaging
Observing system,
Wherein, the lighting system is arranged for irradiating the center of the groove, and the imaging system is arranged to be aligned
The center of the groove.
4. sound wave according to claim 3 drives particle rotating device, which is characterized in that the lighting system includes mercury
Lamp, the first lens and object lens, wherein the mercury lamp is set to the top of the groove, and the object lens are aligned in the groove
The heart, first lens are set between mercury lamp and groove.
5. sound wave according to claim 4 drives particle rotating device, which is characterized in that the imaging system includes
CCD camera, the first spectroscope, the second lens, the second spectroscope and eyepiece, wherein first spectroscopical reflective surface alignment
The object lens and second spectroscopical entering light face, second lens setting the first spectroscope and the second spectroscope it
Between, the CCD camera is directed at second spectroscopical first light splitting surface, the eyepiece alignment described second spectroscopical second
Light splitting surface.
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| CN201910154359.7A CN109839333A (en) | 2019-03-01 | 2019-03-01 | Sound wave drives particle rotating device |
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Cited By (2)
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| CN114822482A (en) * | 2022-03-11 | 2022-07-29 | 南京师范大学 | Coupled acoustic vortex transmitter and application thereof |
| WO2023065064A1 (en) * | 2021-10-18 | 2023-04-27 | Fudan University | Photoacoustic tweezers |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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Application publication date: 20190604 |