CN109833129A - Rats and mice Duodenum-jejunum built-in cannula with screw spring silk - Google Patents
Rats and mice Duodenum-jejunum built-in cannula with screw spring silk Download PDFInfo
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- CN109833129A CN109833129A CN201910179859.6A CN201910179859A CN109833129A CN 109833129 A CN109833129 A CN 109833129A CN 201910179859 A CN201910179859 A CN 201910179859A CN 109833129 A CN109833129 A CN 109833129A
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- hose
- duodenum
- body portion
- elastic ring
- rats
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Abstract
The invention discloses a kind of rats and mice Duodenum-jejunum built-in cannulas with screw spring silk, it is related to medical experiment field, including hose head, hose body portion, elastic ring and the individual pen song spring and grasp being arranged on the hose head, the diameter in the hose body portion is 2-10mm, length 50-200mm, sidewall thickness 0.005mm-0.1mm；The hose head be horn-like, columnar or waist drum shape, length 3mm-10mm, side wall with a thickness of 0.005mm-0.1mm；The hose head elastic ring circular comprising V-type or trapezoidal connecting, the diameter of elastic ring silk is 0.05mm-0.1mm.The configuration of the present invention is simple, mechanics are stablized, easy to operate and good biocompatibility, are able to satisfy the Duodenum-jejunum built-in cannula of rats and mice requirement, which can be placed in duodenum-jejunum by endoscope by upper digestive tract, establish gallbladder pancreas separate system.Screw spring silk is enclosed in hose body portion, can comply with intestines peristalsis, and gastrointestinal peristalsis bring hose body portion collapsing is avoided to lead to jejunal content reflux.
Description
Technical field
The present invention relates to medical experiment fields, more particularly, to a kind of rats and mice Duodeno- with screw spring silk
Casing built in jejunum.
Background technique
Diabetes B pathogenesis is studied at present and probes into treatment method mainly establishes diabetic animal mould with rats and mice
Type, therapeutic modality have drug therapy and metabolic operative treatment popular in recent years, and drug treatment is mainly with insulin
Based on hypoglycemic medicine, there are curative effects it is low, poor resistance and side effect are big the problems such as, be extremely difficult to ideal therapeutic effect.
It is operative treatment compared with drug therapy more efficient way, operation method mainly has sleeve-like gastrectomy, gastric bypass, stomach band
Art, stomach detour art etc., these modus operandis can often obtain preferable therapeutic effect in a short time, therefore will be widely welcomed,
But with the follow-up study of numerous scholars report it is found that these modus operandis while obtaining good therapeutic effect along with crowd
The generation of the risks such as more side effects and sequelae, such as: general anesthesia risk, death, previous anastomotic infection, intestinal contents leakage,
Big bleeding, irreversible neurotrosis, intestinal adhesion etc..
Problems solved by the invention: it is simple to provide a kind of structure, and mechanics is stablized, easy to operate and good biocompatibility, energy
Meet the Duodenum-jejunum built-in cannula of rats and mice requirement, which can pass through upper digestive tract merging ten by endoscope
In two duodenum 12-jejunum, gallbladder pancreas separate system is established.In addition the tight mouth line for tightening pedestal upper end is just easy to take out casing.Make
Casing is made with the smooth material in surface, avoids chyme and shell material adhesion from causing intestinal obstruction, shell material will not be caused
It sticks together with intestinal tissue.Compared with traditional drug therapy and operative treatment, which has operation risk
Small, the generation of hurtless measure infection and chyme leakage etc. will not cause neurotrosis and the generation of intestinal obstruction.
Summary of the invention
To achieve the goals above, the present invention adopts the following technical scheme: a kind of rats and mice ten with screw spring silk
Casing built in two duodenum 12-jejunum, all components are by biocompatible biodegradable or Biodegradable material does not obtain.
The elastic polyurethane film of the shape memory of hose densification smooth by face, soft is constituted, be divided into hose head and
Hose body portion two parts, hose head bulge, hose body portion are straight pipe, and hose head and hose body portion seamlessly transit；It is soft
Tube head is located at duodenal bulb, and tube body can be extended to jejunum.Diameter, length and the thickness in the hose body portion with not
Match with duodenum in rats and mice body and jejunum, diameter 2-10mm, length is matched and extended to duodenum
One section of jejunum being connect with duodenum, length 50-200mm, hose side wall with a thickness of 0.005mm-0.1mm.
The hose head be it is horn-like, be also possible to it is columnar, waist drum shape, hose material with a thickness of
0.005mm-0.1mm is highly 3mm-10mm.Its thickness, highly with different size mouse body phase.Hose head diameter is hose
1-2 times of body portion diameter
Hose head upper limb can be V-type or trapezoidal elastic membrane, the hose head elastic force circular comprising V-type or trapezoidal connecting
Circle.Elastic ring string diameter can be 0.05mm-0.1mm, and the individual pen song spring diameter at peak valley and bent angle can be 0.2mm-0.5mm, elastic ring
It is combined as a whole with hose head.Open and flat elastic ring can be the V-type with individual pen song spring or trapezoidal of peak valley and bent angle.It is described
The open and flat elastic ring of various shape can be with individual pen around hose head, can also be with multi-turn.The angle of grasp is 10 ° -45 °, grasp
Length is 0.1mm-1mm.
The elastic ring on the hose head can be obtained, elastic ring by biocompatible material remember or non-memory
And hose head can integrally comply with duodenum and bulb movement and flexible or elasticity activity.
The exhausting line for passing around elastic ring peak valley and bent angle lower edge individual pen song spring, can be selected biocompatible corrosion resistant memory
Or non-memory high molecular material and metal.In the recycling intestines casing, the exhausting line is lifted toward upper end by endoscope
Into the individual pen song spring of elastic ring upper limb, grasp can be extracted, collapse elastic ring, recycle intestines casing of the present invention.Hose
Screw spring silk is enclosed in body portion, is manufactured by Nitinol marmem, and intestines peristalsis can be complied with, and avoids gastrointestinal peristalsis bring
Hose body portion collapsing, and then lead to jejunal content reflux.
Cylindric or capsule shape can be collapsed or be folded into together in vitro in the hose head with hose body portion, be convenient for
Storage and use.Pipe wall material is soft, smooth, flexible, and stomach juice-resistant and digestive juice, histocompatbility is good, without acute and chronic complete
Body reaction or local reaction.
The present invention can be sent into duodenum and proximal jejunum through upper digestive tract under scope and x-ray perspective auxiliary, if
It is memory material, is then gradually spread out under memory temperature in the intestine, the hose head of intestines casing is located at duodenal cap, hose
The lower edge on head does not hinder gallbladder pancreatic juice to enter enteric cavity in duodenofiberscope and nearly stomach lateral pylorus.The hose body portion of intestines casing
Proximal jejunum portion is extended to by ascending part of duodenum.Grasp on the elastic ring on the intestines casing hose head, insertion of taking advantage of a situation
Duodenum spherical cavity section intestinal mucosa and submucous tissue are fixed on the intestines cannula tip in duodenum.
Duodenum portion sets up chyme and gallbladder pancreatic juice separate system to the present invention in vivo, avoids stomach effluent 12
Digestion, absorption, the metabolism of duodenum 12 and proximal jejunum can be prepared into the fat medical instrument with diabetes of prevention and treatment.
The exhausting line of elastic ring lower edge individual pen song spring is passed around, is located at the opposite lesser duodenal bulb lower edge of stretching, extension, no
Compliance and elasticity that the intestines casing moves duodenum and bulb are influenced, it, will through endoscopic forceps channel when recycling the intestines casing
The exhausting line is lifted toward upper end into the individual pen song spring of elastic ring upper limb, can be extracted grasp, be collapsed elastic ring, the recycling present invention
The intestines casing.
Compared with prior art, effect of the invention is: under endoscope and x-ray monitor auxiliary can safely, quickly, it is quasi-
True conveys duodenum-jejunum casing, and release is installed to inside target enteron aisle, to reach therapeutic purposes, implantation process
It is not painful, hurtless measure；Stationary phase is not easy to shift, can comply with stomach and intestine to secured after Duodenum-jejunum built-in cannula release
It is flexible to wriggle and small to mucosa injury, convenient for taking out；Intestines casing whole smooth connection reduces mechanical stimulus and emergency damage
The generation of wound.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Wherein, 1- hose head；2- hose body portion；3- grasp；4- elastic ring；5- individual pen song spring；The tight mouth exhausting line of 6-；7-
Screw spring silk.
Specific embodiment
The invention will be further described with embodiment with reference to the accompanying drawing.
As shown in Figure 1, a kind of rats and mice Duodenum-jejunum built-in cannula with screw spring silk, by bio-compatible
It is biodegradable or not Biodegradable material be made, mainly by hose head 1, hose body portion 2, elastic ring 4, individual pen song spring
5, grasp 3 and tight mouth exhausting line 6 form.
The material in hose head 1 and hose body portion 2 can be prepared with electrostatic spinning method.Hose head 1 and hose body portion 2 its
The thickness of sidewall film is 0.005mm-0.1mm, in the diameter and length and different size mouse body in hose body portion 2 duodenum and
Jejunum matches, diameter 2mm-10mm, extends to proximal jejunum, length 50mm-200mm, and 1 length of hose head is
3mm-10mm.Hose head 1 and hose body portion 2 seamlessly transit.
Hose head 1 wraps around individual pen elastic ring 4, and elastic ring 4 is combined as a whole with hose head 1, the silk of elastic ring 4
Diameter is 0.05mm, and open and flat elastic ring 4 is multiple continuous V-types, and each individual pen song spring 5 of elastic ring 4 has a grasp 3,
The length of grasp 3 is 0.1mm-1mm, and grasp 3 is towards hose body end, 10 ° -45 ° of angle.Complete elastic ring 4 can be quiet
The preparation of electrospinning method, the electrospinning together with when the film in hose body portion 2 of hose head 1 enters, can also gluing gets on again afterwards.Hose body
Screw spring silk 7 is enclosed in portion 2, can comply with intestines peristalsis, avoids gastrointestinal peristalsis bring hose body portion collapsing, and then lead to jejunum
Content reflux.Elastic ring, individual pen song spring and screw spring silk are manufactured by Nitinol marmem, and string diameter used is
0.05mm。
After prepared by hose head 1 with complete elastic ring 4 and hose body portion 2, manually by tight mouth exhausting line 6 according to
The secondary individual pen song spring 5 across 4 lower edge of elastic ring, passes around one week, and knotting or glued tail end subtract additional length.
Hose is folded by the rats and mice Duodenum-jejunum built-in cannula with screw spring silk that finishes of preparation is regular
In head 1, the centripetal elastic ring 4 for gathering hose head 1 is made cylindric or capsule shape, and when use puts it into pusher, borrows
Endoscope and X-ray examination are helped, duodenal bulb and its extended segment are precisely placed in.
When recycling intestines casing described in this patent, tight mouth exhausting line 6 is lifted toward upper end to elastic ring 4 through endoscopic forceps channel
In the individual pen song spring 3 of upper limb, grasp 3 can be extracted, collapse elastic ring 4, recycle the size with screw spring silk of the invention
Mouse Duodenum-jejunum built-in cannula.
Above-mentioned, although the foregoing specific embodiments of the present invention is described with reference to the accompanying drawings, not protects model to the present invention
The limitation enclosed, for some technology contents well known to those of ordinary skill in the art, details are not described herein again, fields technology
Personnel should be understood that based on the technical solutions of the present invention those skilled in the art do not need to make the creative labor i.e.
The various modifications or changes that can be made are still within protection scope of the present invention.
Claims (3)
1. a kind of rats and mice Duodenum-jejunum built-in cannula with screw spring silk, which is characterized in that including hose head
Portion, hose body portion, elastic ring and the individual pen song spring and grasp being arranged on the hose head, the hose
The diameter in body portion is 2-10mm, length 50-200mm, sidewall thickness 0.005mm-0.1mm；The hose head is
Horn-like, columnar or waist drum shape, length 3mm-10mm, side wall with a thickness of 0.005mm-0.1mm；The hose head
Portion's elastic ring circular comprising V-type or trapezoidal connecting, the diameter of elastic ring silk is 0.05mm-0.1mm；Enclose spiral in hose body portion
Elastic filament is manufactured by Nitinol marmem, can comply with intestines peristalsis, avoids gastrointestinal peristalsis bring hose body portion flat
It collapses, and then leads to jejunal content reflux.
2. the rats and mice Duodenum-jejunum built-in cannula according to claim 1 with screw spring silk, feature exist
In the individual pen song spring diameter is 0.2mm-0.5mm.
3. the rats and mice Duodenum-jejunum built-in cannula according to claim 1 with screw spring silk, feature exist
In the side wall on the grasp and hose head forms 10 ° of -45 ° of angles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910179859.6A CN109833129A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula with screw spring silk |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910179859.6A CN109833129A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula with screw spring silk |
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| Publication Number | Publication Date |
|---|---|
| CN109833129A true CN109833129A (en) | 2019-06-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910179859.6A Withdrawn CN109833129A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula with screw spring silk |
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| CN (1) | CN109833129A (en) |
Citations (5)
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|---|---|---|---|---|
| CN101417152A (en) * | 2007-09-18 | 2009-04-29 | 科迪斯公司 | Local vascular delivery with the mTOR inhibitor of peroxisome Proliferator-activated receptor stimulant associating |
| CN103142262A (en) * | 2013-03-31 | 2013-06-12 | 万平 | Inner coverage membrane for duodenum |
| CN103315785A (en) * | 2007-09-17 | 2013-09-25 | 柯惠Lp公司 | Method of forming barbs on suture |
| CA2918492A1 (en) * | 2013-07-18 | 2015-01-22 | Ping Wan | Duodenal membrane with microarray adhesive piece |
| CN204468356U (en) * | 2014-11-11 | 2015-07-15 | 浙江大学 | Stomach wall urine stream Efferent tube man-made support |
-
2019
- 2019-03-11 CN CN201910179859.6A patent/CN109833129A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315785A (en) * | 2007-09-17 | 2013-09-25 | 柯惠Lp公司 | Method of forming barbs on suture |
| CN101417152A (en) * | 2007-09-18 | 2009-04-29 | 科迪斯公司 | Local vascular delivery with the mTOR inhibitor of peroxisome Proliferator-activated receptor stimulant associating |
| CN103142262A (en) * | 2013-03-31 | 2013-06-12 | 万平 | Inner coverage membrane for duodenum |
| CA2918492A1 (en) * | 2013-07-18 | 2015-01-22 | Ping Wan | Duodenal membrane with microarray adhesive piece |
| WO2015007121A1 (en) * | 2013-07-18 | 2015-01-22 | Wan Ping | Medical instrument and application thereof |
| CN204468356U (en) * | 2014-11-11 | 2015-07-15 | 浙江大学 | Stomach wall urine stream Efferent tube man-made support |
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Application publication date: 20190604 |