CN109833128A - Rats and mice Duodenum-jejunum built-in cannula - Google Patents
Rats and mice Duodenum-jejunum built-in cannula Download PDFInfo
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- CN109833128A CN109833128A CN201910178390.4A CN201910178390A CN109833128A CN 109833128 A CN109833128 A CN 109833128A CN 201910178390 A CN201910178390 A CN 201910178390A CN 109833128 A CN109833128 A CN 109833128A
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- duodenum
- hose
- elastic ring
- jejunum
- rats
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Abstract
The invention discloses a kind of rats and mice Duodenum-jejunum built-in cannulas, it is related to medical experiment field, including hose head, hose body portion, elastic ring and the individual pen song spring and grasp being arranged on the hose head, the diameter in the hose body portion is 2-10mm, length 50-200mm, sidewall thickness 0.005mm-0.1mm；The hose head be horn-like, columnar or waist drum shape, length 3mm-10mm, side wall with a thickness of 0.005mm-0.1mm；The hose head elastic ring circular comprising V-type or trapezoidal connecting, the diameter of elastic ring silk is 0.05mm-0.1mm.The configuration of the present invention is simple, mechanics are stablized, easy to operate and good biocompatibility, are able to satisfy the Duodenum-jejunum built-in cannula of rats and mice requirement, which can be placed in duodenum-jejunum by endoscope by upper digestive tract, establish gallbladder pancreas separate system.
Description
Technical field
The present invention relates to medical experiment fields, more particularly, to a kind of rats and mice Duodenum-jejunum built-in cannula.
Background technique
Diabetes B pathogenesis is studied at present and probes into treatment method mainly establishes diabetic animal mould with rats and mice
Type, therapeutic modality have drug therapy and metabolic operative treatment popular in recent years, and drug treatment is mainly with insulin
Based on hypoglycemic medicine, there are curative effects it is low, poor resistance and side effect are big the problems such as, be extremely difficult to ideal therapeutic effect.
It is operative treatment compared with drug therapy more efficient way, operation method mainly has sleeve-like gastrectomy, gastric bypass, stomach band
Art, stomach detour art etc., these modus operandis can often obtain preferable therapeutic effect in a short time, therefore will be widely welcomed,
But with the follow-up study of numerous scholars report it is found that these modus operandis while obtaining good therapeutic effect along with crowd
The generation of the risks such as more side effects and sequelae, such as: general anesthesia risk, death, previous anastomotic infection, intestinal contents leakage,
Big bleeding, irreversible neurotrosis, intestinal adhesion etc..
Problems solved by the invention: it is simple to provide a kind of structure, and mechanics is stablized, easy to operate and good biocompatibility, energy
Meet the Duodenum-jejunum built-in cannula of rats and mice requirement, which can pass through upper digestive tract merging ten by endoscope
In two duodenum 12-jejunum, gallbladder pancreas separate system is established.In addition the tight mouth line for tightening pedestal upper end is just easy to take out casing.Make
Casing is made with the smooth material in surface, avoids chyme and shell material adhesion from causing intestinal obstruction, shell material will not be caused
It sticks together with intestinal tissue.Compared with traditional drug therapy and operative treatment, which has operation risk
Small, the generation of hurtless measure infection and chyme leakage etc. will not cause neurotrosis and the generation of intestinal obstruction.
Summary of the invention
To achieve the goals above, the present invention adopts the following technical scheme: a kind of built-in set of rats and mice duodenum-jejunum
Pipe, all components are by biocompatible biodegradable or Biodegradable material does not obtain.
The film of hose densification smooth by surface, soft is constituted, and is divided into hose head and hose body portion two parts, hose
Head bulge, hose body portion are straight pipe, and hose head and hose body portion seamlessly transit；Hose head is located at duodenal bulb
Portion, tube body can be extended to jejunum.Duodenum in diameter, length and the thickness and different size mouse body in the hose body portion
And jejunum matches, diameter 2-10mm, length matches with duodenum and extends to one section connect with duodenum
Jejunum, length 50-200mm, hose side wall with a thickness of 0.005mm-0.1mm.
The hose head be it is horn-like, be also possible to it is columnar, waist drum shape, hose material with a thickness of
0.005mm-0.1mm is highly 3mm-10mm.Its thickness, highly with different size mouse body phase.Hose head diameter is hose
1-2 times of body portion diameter
Hose head upper limb can be V-type or trapezoidal elastic membrane, the hose head elastic force circular comprising V-type or trapezoidal connecting
Circle.Elastic ring string diameter can be 0.05mm-0.1mm, and the individual pen song spring diameter at peak valley and bent angle can be 0.2mm-0.5mm, elastic ring
It is combined as a whole with hose head.Open and flat elastic ring can be the V-type with individual pen song spring or trapezoidal of peak valley and bent angle.It is described
The open and flat elastic ring of various shape can be with individual pen around hose head, can also be with multi-turn.The angle of grasp is 10 ° -45 °, grasp
Length is 0.1mm-1mm.
The elastic ring on the hose head can be obtained, elastic ring by biocompatible material remember or non-memory
And hose head can integrally comply with duodenum and bulb movement and flexible or elasticity activity.
The exhausting line for passing around elastic ring peak valley and bent angle lower edge individual pen song spring, can be selected biocompatible corrosion resistant memory
Or non-memory high molecular material and metal.In the recycling intestines casing, the exhausting line is lifted toward upper end by endoscope
Into the individual pen song spring of elastic ring upper limb, grasp can be extracted, collapse elastic ring, recycle intestines casing of the present invention.
Cylindric or capsule shape can be collapsed or be folded into together in vitro in the hose head with hose body portion, be convenient for
Storage and use.Pipe wall material is soft, smooth, flexible, and stomach juice-resistant and digestive juice, histocompatbility is good, without acute and chronic complete
Body reaction or local reaction.
The present invention can be sent into duodenum and proximal jejunum through upper digestive tract under scope and x-ray perspective auxiliary, if
It is memory material, is then gradually spread out under memory temperature in the intestine, the hose head of intestines casing is located at duodenal cap, hose
The lower edge on head does not hinder gallbladder pancreatic juice to enter enteric cavity in duodenofiberscope and nearly stomach lateral pylorus.The hose body portion of intestines casing
Proximal jejunum portion is extended to by ascending part of duodenum.Grasp on the elastic ring on the intestines casing hose head, insertion of taking advantage of a situation
Duodenum spherical cavity section intestinal mucosa and submucous tissue are fixed on the intestines cannula tip in duodenum.
Duodenum portion sets up chyme and gallbladder pancreatic juice separate system to the present invention in vivo, avoids stomach effluent 12
Digestion, absorption, the metabolism of duodenum 12 and proximal jejunum can be prepared into the fat medical instrument with diabetes of prevention and treatment.
The exhausting line of elastic ring lower edge individual pen song spring is passed around, is located at the opposite lesser duodenal bulb lower edge of stretching, extension, no
Compliance and elasticity that the intestines casing moves duodenum and bulb are influenced, it, will through endoscopic forceps channel when recycling the intestines casing
The exhausting line is lifted toward upper end into the individual pen song spring of elastic ring upper limb, can be extracted grasp, be collapsed elastic ring, the recycling present invention
The intestines casing.
Compared with prior art, effect of the invention is: under endoscope and x-ray monitor auxiliary can safely, quickly, it is quasi-
True conveys duodenum-jejunum casing, and release is installed to inside target enteron aisle, to reach therapeutic purposes, implantation process
It is not painful, hurtless measure；Stationary phase is not easy to shift, can comply with stomach and intestine to secured after Duodenum-jejunum built-in cannula release
It is flexible to wriggle and small to mucosa injury, convenient for taking out；Intestines casing whole smooth connection reduces mechanical stimulus and emergency damage
The generation of wound.
Detailed description of the invention
Fig. 1 is the structural diagram of the present invention；
Wherein, 1- hose head；2- hose body portion；3- grasp；4- elastic ring；5- individual pen song spring；The tight mouth exhausting line of 6-.
Specific embodiment
The invention will be further described with embodiment with reference to the accompanying drawing.
As shown in Figure 1, a kind of rats and mice Duodenum-jejunum built-in cannula, by biocompatible biodegradable or not
Biodegradable material is made, and is mainly returned by hose head 1, hose body portion 2, elastic ring 4, individual pen song spring 5, grasp 3 and tight mouth
Take-up 6 forms.
The material in hose head 1 and hose body portion 2 can be prepared with electrostatic spinning method.Hose head 1 and hose body portion 2 its
The thickness of sidewall film is 0.005mm-0.1mm, in the diameter and length and different size mouse body in hose body portion 2 duodenum and
Jejunum matches, diameter 2mm-10mm, extends to proximal jejunum, length 50mm-200mm, and 1 length of hose head is
3mm-10mm.Hose head 1 and hose body portion 2 seamlessly transit.
Hose head 1 wraps around individual pen elastic ring 4, and elastic ring 4 is combined as a whole with hose head 1, the silk of elastic ring 4
Diameter is 0.05mm, and open and flat elastic ring 4 is multiple continuous V-types, and each individual pen song spring 5 of elastic ring 4 has a grasp 3,
The length of grasp 3 is 0.1mm-1mm, and grasp 3 is towards hose body end, 10 ° -45 ° of angle.Complete elastic ring 4 can be quiet
The preparation of electrospinning method, the electrospinning together with when the film in hose body portion 2 of hose head 1 enters, can also gluing gets on again afterwards.Elastic force
Circle, individual pen song spring are manufactured by Nitinol marmem, and string diameter used is 0.05mm.
After prepared by hose head 1 with complete elastic ring 4 and hose body portion 2, manually by tight mouth exhausting line 6 according to
The secondary individual pen song spring 5 across 4 lower edge of elastic ring, passes around one week, and knotting or glued tail end subtract additional length.
It folds into the rats and mice Duodenum-jejunum built-in cannula that finishes of preparation is regular in hose head 1, it is centripetal to gather
The elastic ring 4 on hose head 1, is made cylindric or capsule shape, and when use puts it into pusher, saturating by endoscope and x-ray
Depending on being precisely placed in duodenal bulb and its extended segment.
When recycling intestines casing described in this patent, tight mouth exhausting line 6 is lifted toward upper end to elastic ring 4 through endoscopic forceps channel
In the individual pen song spring 3 of upper limb, grasp 3 can be extracted, collapse elastic ring 4, recycled in rats and mice duodenum-jejunum of the invention
Set casing.
Above-mentioned, although the foregoing specific embodiments of the present invention is described with reference to the accompanying drawings, not protects model to the present invention
The limitation enclosed, for some technology contents well known to those of ordinary skill in the art, details are not described herein again, fields technology
Personnel should be understood that based on the technical solutions of the present invention those skilled in the art do not need to make the creative labor i.e.
The various modifications or changes that can be made are still within protection scope of the present invention.
Claims (3)
1. a kind of rats and mice Duodenum-jejunum built-in cannula, which is characterized in that including hose head, hose body portion, elastic ring
And individual pen song spring and grasp on the hose head are set, the diameter in the hose body portion is 2-
10mm, length 50-200mm, sidewall thickness 0.005mm-0.1mm；The hose head be it is horn-like, columnar or
Waist drum shape, length 3mm-10mm, side wall with a thickness of 0.005mm-0.1mm；The hose head includes V-type or trapezoidal
Circular elastic ring is connected, the diameter of elastic ring silk is 0.05mm-0.1mm.
2. rats and mice Duodenum-jejunum built-in cannula according to claim 1, which is characterized in that the individual pen is bent
Spring diameter is 0.2mm-0.5mm.
3. rats and mice Duodenum-jejunum built-in cannula according to claim 1, which is characterized in that the grasp with
The side wall on hose head forms 10 ° of -45 ° of angles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910178390.4A CN109833128A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910178390.4A CN109833128A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109833128A true CN109833128A (en) | 2019-06-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910178390.4A Withdrawn CN109833128A (en) | 2019-03-11 | 2019-03-11 | Rats and mice Duodenum-jejunum built-in cannula |
Country Status (1)
| Country | Link |
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| CN (1) | CN109833128A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060161265A1 (en) * | 2002-12-02 | 2006-07-20 | Levine Andy H | Bariatric sleeve |
| CN201987704U (en) * | 2010-12-06 | 2011-09-28 | 北京畅想天行医疗技术有限公司 | Duodenum-jejunum built-in cannula |
| CN102626330A (en) * | 2012-05-05 | 2012-08-08 | 万平 | Duodenal internal covering membrane made of degradable biocompatible material and application thereof |
| CN103142338A (en) * | 2013-03-26 | 2013-06-12 | 巴克 | Duodenum casing for treating diabetes implanted under endoscope |
| CN103142262A (en) * | 2013-03-31 | 2013-06-12 | 万平 | Inner coverage membrane for duodenum |
-
2019
- 2019-03-11 CN CN201910178390.4A patent/CN109833128A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060161265A1 (en) * | 2002-12-02 | 2006-07-20 | Levine Andy H | Bariatric sleeve |
| CN201987704U (en) * | 2010-12-06 | 2011-09-28 | 北京畅想天行医疗技术有限公司 | Duodenum-jejunum built-in cannula |
| CN102626330A (en) * | 2012-05-05 | 2012-08-08 | 万平 | Duodenal internal covering membrane made of degradable biocompatible material and application thereof |
| CN103142338A (en) * | 2013-03-26 | 2013-06-12 | 巴克 | Duodenum casing for treating diabetes implanted under endoscope |
| CN103142262A (en) * | 2013-03-31 | 2013-06-12 | 万平 | Inner coverage membrane for duodenum |
| US20160030221A1 (en) * | 2013-03-31 | 2016-02-04 | Ping Wan | Internal covering membrane of duodenum |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190604 |