CN109833111A

CN109833111A - A kind of anchor log and anchoring device

Info

Publication number: CN109833111A
Application number: CN201811460229.8A
Authority: CN
Inventors: 汪振; 傅振中; 富佳伟; 阙亦云; 章艺
Original assignee: Minimally Invasive Medical Technology (jiaxing) Co Ltd
Current assignee: Minimally Invasive Medical Technology (jiaxing) Co Ltd
Priority date: 2018-11-30
Filing date: 2018-11-30
Publication date: 2019-06-04
Also published as: CN111297510A; CN111297510B

Abstract

The present invention provides a kind of anchor log and anchoring device, to be easy displacement after solving the problems, such as existing anchor log and anchoring device implantation.The anchor log includes contact surface and non-contact face, and the contact surface is used to contact with each other with a tissue, and the contact surface includes at least one recessed portion and/or at least one lug boss.The anchoring device includes that distal end anchoring, connector and the anchor log, the connector are selectively connected with the anchor log, and the connector is fixedly connected with distal end anchoring.Anchor log and anchoring device in the present invention, since the anchor log includes contact surface and non-contact face, the contact surface includes at least one recessed portion and/or at least one lug boss, therefore the roughness of the contact surface can be greater than the roughness in the non-contact face, therefore the adherent performance of anchor log can be improved, the risk for reducing the displacement of anchor log relative organization, so that the anchorage stability of anchoring device improves.

Description

A kind of anchor log and anchoring device

Technical field

The present invention relates to the field of medical instrument technology, in particular to a kind of anchor log and anchoring device.

Background technique

Benign prostatic hyperplasis is to cause a kind of benign disease most commonly seen in middle-aging male urination disorder problem.It is main Want hyperplasia, the forefront hylperadenosis anatomically, lower urinary tract symptom of the prostate interstitial and body of gland ingredient in exhibit tissue Based on clinical symptoms and urodynamics on bladder outlet obstruction.

In addition to drug therapy, the modus operandi of benign prostatic hyperplasis has following several: (1) transurethral resection of prostate Art；(2) on pubis or retropubic prostatectomy；(3) Lasar prostate enucleation or resection；(4) prostate bracket exists Interior minimally invasive treatment.

A kind of anchoring device is generallyd use in minimally invasive treatment including prostate bracket, this anchoring device is a kind of use In the permanent implant for alleviating small urinary stream.This anchoring device is implanted into urethra by transportation system, mechanicalness after implantation Ground separates two leaf of prostate or so, and the prostata tissue of urethra is pushed open, to play the effect for the treatment of.This anchor The invasion for determining device is extremely low, and without being melted, can be with the symptom of lasting remission patient, and therapeutic effect is preferable.

Currently, anchoring device generally include distal end be anchored, proximal end anchoring and connector, the connector respectively with it is described Distal end anchoring and proximal end anchoring connection.There is the risk of displacement after the implantation of this anchoring device, the validity for the treatment of and steady It is qualitative etc. to need to improve.

Summary of the invention

The purpose of the present invention is to provide a kind of anchor log and anchoring devices, to solve existing anchor log and anchoring device The problem of displacement is easy after implantation.

In order to solve the above technical problems, the present invention provides a kind of anchor log, including contact surface and non-contact face, the contact Face is used to contact with each other with a tissue, and the contact surface includes at least one recessed portion and/or at least one lug boss.

Optionally, further include drug, the drug is equipped in the recessed portion.

It optionally, further include protective layer, the protective layer is covered on the drug.

Optionally, the lug boss has at least one tip.

Optionally, the recessed portion includes at least one first groove, and first groove connects along the first predetermined direction Continuous setting.

Optionally, the lug boss further includes at least one first protrusion, and first protrusion is along multiple described first The orientation of groove is staggered with multiple first grooves.

Optionally, first protrusion includes at least one second groove, and second groove is along the second predetermined direction Continuous setting.

Optionally, first protrusion further includes at least one second protrusion, and second protrusion is arranged described second The two sides of groove.

Optionally, the recessed portion includes at least one third groove, and the third groove is in spot distribution and/or institute Stating third groove is a through-hole and/or blind hole.

Optionally, the recessed portion includes at least one the 4th groove, length of the 4th groove along the anchor log The shape of directional spreding and/or the 4th groove is waveform and/or zigzag.

Optionally, for being selectively connected with connector, the anchor log further includes the first clamping part, the second clamping Portion, the first shrapnel part and the second shrapnel part, first clamping part have the first fixing end and the first free end, second folder Portion is held with the second fixing end and the second free end, first shrapnel part has third fixing end and third free end, described Second shrapnel part has the 4th fixing end and the 4th free end, the first fixing end of first clamping part and first elastic slice The third fixing end in portion is fixedly connected, the 4th fixing end of the second fixing end of second clamping part and second shrapnel part It is fixedly connected, the first fixing end of first clamping part is connected with the second fixing end of second clamping part, the connection Part is selectively connected with first clamping part and second clamping part；When the connector and first clamping part and When second clamping part connects, first clamping part and the second clamping part clamp the connector.

The present invention also provides a kind of anchoring devices, including distal end anchoring, connector and above-mentioned anchor log, the connection Part is selectively connected with the anchor log, and the connector is fixedly connected with distal end anchoring.

A kind of anchor log and anchoring device provided by the invention, have the advantages that

Firstly, since the proximal end anchoring has the contact surface to contact with each other with tissue, the contact surface includes at least one A recessed portion and/or at least one lug boss, therefore the roughness of the contact surface can be greater than outside other of proximal end anchoring Surface, therefore the adherent performance of proximal end anchoring can be improved, the risk of proximal end anchoring relative organization displacement is reduced, so that anchoring device Anchorage stability improve.

Secondly as drug can treat tissue, the drug being arranged in recessed portion can realize Targeting delivery, into one Step improves the therapeutic effect of anchoring device, and drugloading rate can also be reduced while playing identical therapeutic effect.

Secondly as the protective layer is covered on the outer surface of outer surface side of the drug far from the recessed portion On, therefore the speed of drug wastage can be slowed down, improve the release conditions of drug, so as to improve therapeutic effect.Especially work as anchoring When there is the substance of flowing around device, the substance that can be effectively prevented from these flowings directly washes away drug, leads to drug wastage, Influence therapeutic effect.

Again, first protrusion can further increase the roughness of contact surface, improve the adherent performance of proximal end anchoring, drop The risk of low proximal end anchoring relative organization displacement, so that the anchorage stability of anchoring device improves.

Again secondary, when being pierced into tissue due to the tip of the first protrusion, the drug in the first groove is also easier to penetrate into group In knitting, the drugloading rate in the first groove can be reduced accordingly, and the validity of drug can improve, while cost is reduced, can be maximum Improve to degree the utilization rate of drug.In addition, the tip in first protrusion can further increase the roughness of contact surface, mention The adherent performance of high proximal end anchoring reduces the risk of proximal end anchoring relative organization displacement, so that the anchorage stability of anchoring device It improves.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of the anchoring device in the embodiment of the present invention one；

Fig. 2 is a kind of structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention one；

Fig. 3 is a kind of structural schematic diagram of the distal end anchoring in the anchoring device in the embodiment of the present invention one；

Fig. 4 is another structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention one；

Fig. 5 is the cross-sectional view of the proximal end anchor portion in the anchoring device in the embodiment of the present invention one；

Fig. 6 is the schematic diagram after the anchoring device implantation urethra in the embodiment of the present invention one；

Fig. 7 is the first schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Fig. 8 is second of schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Fig. 9 is the third schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Figure 10 is the 4th kind of schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Figure 11 is the 5th kind of schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Figure 12 is the 6th kind of schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Figure 13 is the 7th kind of schematic diagram in the anchoring device implantation urethra in the embodiment of the present invention one；

Figure 14 is a kind of structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention two；

Figure 15 is another structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention two；

Figure 16 is a kind of structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention three；

Figure 17 is a kind of structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention four；

Figure 18 is a kind of structural schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention five；

Figure 19 is the structural schematic diagram of the anchoring device in the embodiment of the present invention six；

Figure 20 is a kind of schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention six；

Figure 21 is the stress analysis schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention six；

Figure 22 is another schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention six；

Figure 23 is the schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention seven；

Figure 24 is the cross-sectional view of the proximal end anchoring in the anchoring device in the embodiment of the present invention eight；

Figure 25 is the schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention nine；

Figure 26 is the schematic diagram of the proximal end anchoring in the anchoring device in the embodiment of the present invention ten；

Figure 27 is the structural schematic diagram of the anchoring device in the embodiment of the present invention 11；

Figure 28 is the cross-sectional view of one of the embodiment of the present invention 11 anchoring device；

Figure 29 is schematic diagram when distally anchoring is equipped with drug in anchoring device in the embodiment of the present invention 11；

Figure 30 is schematic diagram when distally anchoring is equipped with drug in anchoring device in the embodiment of the present invention 12；

Figure 31 is schematic diagram when distally anchoring is equipped with drug in anchoring device in the embodiment of the present invention 13；

Figure 32 is schematic diagram when distally anchoring is equipped with drug in anchoring device in the embodiment of the present invention 14；

Figure 33 is the schematic diagram of the distal end anchoring in the embodiment of the present invention 15.

Specific embodiment

Anchor log proposed by the present invention and anchoring device are made further specifically below in conjunction with the drawings and specific embodiments It is bright.According to following explanation and claims, advantages and features of the invention will be become apparent from.It should be noted that attached drawing is all made of Very simplified form and use non-accurate ratio, only to it is convenient, lucidly aid in illustrating the mesh of the embodiment of the present invention 's.

Herein, it whether explicitly points out, all numerical value are all assumed that available term " about " is modified.? Using in the context of numerical value, term " about ", which typically refers to those skilled in the art, will be considered to be equal to cited value The range of one value of (that is, with identical function or result).In many cases, term " about " may include being rounded To the numerical value of nearest effective digital.Outer unless otherwise prescribed, other are to the use of term " about " (i.e. in addition to using numerical value In context in addition) it can be assumed that there is its common and habitual definition, as that can be understood according to the context of this specification And be consistent with it.

" proximal end " and " distal end " in above-described embodiment is from using doctor's angle of the medical instrument to carry out read fortune for that This element or the relative bearing of movement, relative position, direction, although " proximal end " and " distal end " not be it is restrictive, " proximal end " is often referred to the Medical Devices in course of normal operation close to one end of doctor, and " distal end " typically refers to initially enter One end of patient's body.In addition, term "or" in above-described embodiment be usually carried out with including the meaning of "and/or" using , except in addition explicitly pointing out.

As used in the specification and the appended claims, singular "a", "an" and "the" includes Plural reference, in addition in addition non-content explicitly points out.As used in the specification and the appended claims, term "or" Usually carried out with including the meaning of "and/or" using, in addition in addition non-content explicitly points out.

Embodiment one

The present embodiment provides a kind of anchoring devices.With reference to the anchoring that Fig. 1, Fig. 2 and Fig. 3, Fig. 1 are in the embodiment of the present invention one The structural schematic diagram of device, Fig. 2 and Fig. 3 are proximal end anchoring 100 in the anchoring device in the embodiment of the present invention one respectively and remote The structural schematic diagram of end anchoring 200, anchoring device include proximal end anchoring 100, distal end anchoring 200 and connector 300, proximal end anchoring 100 include contact surface 110 and non-contact face, and for contact surface 110 for contacting with each other with tissue, contact surface 110 includes at least one Recessed portion and/or at least one lug boss, depressions or protrusions portion include but is not limited to slot, decorative pattern, frosting etc..Connector 300 include first connecting portion and the second connecting portion extended from one end of first connecting portion, second connecting portion and proximal anchor Fixed 100 are selectively connected, and first connecting portion is fixedly connected with distal end anchoring 200.

Since proximal end anchoring 100 includes non-contact face and the contact surface 110 to contact with each other with tissue, and contact surface 110 wraps At least one recessed portion and/or at least one lug boss are included, therefore the roughness of contact surface 110 can be greater than the coarse of non-contact face Degree, therefore the adherent performance of proximal end anchoring 100 can be improved, the risk that proximal end is anchored the displacement of 100 relative organizations is reduced, so that anchoring The anchorage stability of device improves.

Specifically, the contact surface 110 of proximal end anchoring 100 includes at least one recessed portion, so that the roughness of contact surface 110 Greater than the roughness in non-contact face.Since the contact surface 110 of proximal end anchoring 100 is proximally anchored including multiple from contact surface 110 The recessed portion of 100 internal stretch, therefore the roughness of contact surface 110 can be increased, so as to increase the opposite group of proximal end anchoring 100 Mobile frictional resistance is knitted, and then the adherent performance of proximal end anchoring 100 can be improved, proximal end is reduced and is anchored the displacement of 100 relative organizations Risk so that the anchorage stability of anchoring device improves；The contact area that contact surface 110 and tissue can also be increased, to change The anchorage stability of kind anchoring device.

Be with reference to Fig. 4, Fig. 4 in the anchoring device in the embodiment of the present invention one proximal end anchoring 100 another structure show It is intended to, recessed portion includes at least one first groove 111, multiple continuously settings of first groove 111.First groove 111 can be U-shaped Slot or V-groove.First groove 111 can be anchored two sides adjacent with contact surface 110 in 100 with proximal end and be connected to, can also be only It is connected to a side adjacent with contact surface 110 in proximal end anchoring 100, or is anchored in 100 and 110 phase of contact surface with proximal end Two adjacent sides form two side protrusions.With reference to Fig. 4, proximal end anchoring 100 is in long plate shape, multiple first grooves 111 along The length direction distribution of proximal end anchoring 100.In other examples, multiple first grooves 111 can also be anchored 100 along proximal end Width direction distribution or any direction distribution.

Preferably, with reference to Fig. 4, multiple first grooves 111 are uniformly distributed along the length direction of proximal end anchoring 100, so as to In processing.First groove 111 can be processed by modes such as Passivation Treatment processing, annular knurl processing, laser processing, electrical discharge machinings Type.Proximal end anchoring 100 can be metal material or high molecular material, and the material of proximal end anchoring 100 can be degradable material or non-drop Solve material.

It preferably, is that proximal end in anchoring device in the embodiment of the present invention one is anchored cuing open for 100 parts with reference to Fig. 5, Fig. 5 View, anchoring device further include drug 400, and drug 400 is accommodated in recessed portion (with reference to the first groove 111 in Fig. 4).Work as anchor After determining device fixation in the tissue, it can be treated by 400 pairs of tissues of drug, the drug 400 being arranged in recessed portion can be real Existing Targeting delivery also can avoid urethra and affect the treatment to washing away for a long time for drug 400, further improve the treatment effect of anchoring device Fruit can also reduce drugloading rate while playing identical therapeutic effect.

Drug 400 can be anti-cell proliferation agents 400, such as rapamycin, taxol, Zuo Tamosi, everolimus Deng.When being used to treat benign prostatic hyperplasis in anchoring device implantation urethra, the drug 400 in anchoring device can inhibit forefront The further hyperplasia of gland, so as to reduce urethra restenosis problem caused by hyperplasia of prostate after anchoring device is implanted into.Drug 400 can Directly it is arranged in recessed portion by spraying or in a manner of drug recrystallization.

Further, with reference to Fig. 5, anchoring device further includes protective layer 500, and protective layer 500 is arranged in recessed portion, and covers It covers on drug 400.To slow down the speed of the loss of drug 400, improve the release conditions of drug 400, so as to improve treatment effect Fruit, when there is the substance of flowing especially around anchoring device, the substance that can avoid these flowings directly washes away drug 400, Cause drug 400 to be lost, influences therapeutic effect.

Further, proximal end, which is anchored on other outer surfaces that 100 remove contact surface 110, may also set up drug 400.Proximal anchor It is removed on fixed 100 contact surface 110 on other outer surfaces at recessed portion and may also set up medicine on the outer surface of connector 300 Object 400.

Preferably, with reference to Fig. 4, contact surface 110 further includes multiple first protrusions 112, and the first protrusion 112 is alongst It is staggered with multiple first grooves 111.In this way, the first protrusion 112 can further increase the roughness of contact surface 110, improve The adherent performance of proximal end anchoring 100 reduces the risk that proximal end is anchored the displacement of 100 relative organizations, so that the anchoring of anchoring device is steady Qualitative raising.

Preferably, the first protrusion 112 has at least one tip.When the tip of each first protrusion 112 is pierced into tissue, the Drug 400 in one groove 111 is also easier to penetrate into tissue, and the drugloading rate in the first groove 111 can be reduced accordingly, medicine The validity of object 400 can improve, and while cost is reduced, can farthest improve the utilization rate of drug 400.In addition, the Tip in one protrusion 112 can further increase the roughness of contact surface 110, improve the adherent performance of proximal end anchoring 100, reduce Proximal end is anchored the risk of 100 relative organizations displacement, so that the anchorage stability of anchoring device improves.

Specifically, distal end anchoring 200 includes anchoring body 210, and extends from anchoring body 210 with reference to Fig. 1 and Fig. 2 And the bending part 220 bent.It can be conducive to distal end anchoring 200 being fixed on organization internal by setting bending part 220, reduce distal end The risk that portion shifts within the organization of anchoring 200.Distal end anchoring 200 can be metal material or high molecular material, distal end anchoring 200 Material can be degradable material or non-degradable material.

Connector 300 is separated from each other before implantation with proximal end anchoring 100, and connector 300 can planted with proximal end anchoring 100 It is assembled and fixed during entering to corresponding tissue.After the completion of anchoring device implantation, connector 300 and proximal end anchoring 100 connect It connects, and connector 300 and the position of proximal end anchoring 100 are relatively fixed.Connector 300 can be metal material or macromolecule material Material, metal material or high molecular material can also be degradable or non-degradable material.

It is the schematic diagram after the anchoring device implantation urethra in the embodiment of the present invention one with reference to Fig. 6 to Figure 13, Fig. 6, Fig. 7 is extremely Figure 13 be respectively in the embodiment of the present invention one anchoring device implantation urethra in the first, second, the third, the 4th kind, 5th kind, the 6th kind and the 7th kind schematic diagram, anchoring device are implanted into after urethra mechanically by left lobe of prostate P1 and prostate Lobus dexter P2 is separated, and the hyperplastic prostate tissue of urethra is pushed back at a distance, specific with the process for treating benign prostatic hyperplasis As follows, similar anchoring device also can plant in other anatomical structures to treat other diseases.

Firstly, sheath 810 advances through urethra, so that the distal end of sheath 810 be made to be placed on urethra by loose prostate Organize the areas adjacent hindered；And anchoring transmission device 820 in distal end is introduced by sheath 810, before distal end is anchored transmission device 820 Into sheath 810 is passed through, so that the distal end of distal end anchoring transmission device 820 comes out from the distal end of sheath 810.Wherein, may be used After the areas adjacent that the distal end of sheath 810 is placed on that urethra is obstructed, distal end anchoring transmission device 820 is put into sheath In 810, or distal end anchoring transmission device 820 can be pre-loaded in sheath 810 before placing sheath 810.Distal end is anchored Situation of the distal end of transmission device 820 after coming out in the distal end of sheath 810 can refer to Fig. 7.

Secondly, being anchored transmission device 820 by distal end introduces acicular delivery pipe 830, acicular delivery pipe 830 is advanced logical Distal end anchoring transmission device 820 is crossed, so that acicular delivery pipe 830 is opened by the distal end that distal end is anchored transmission device 820 Mouth reaches the outside of sheath 810, and acicular delivery pipe 830 is advanced further, and pierces through the tissue of prostate and acicular conveying The distal end of pipe 830 comes out from prostatic utriculus, with reference to Fig. 8.

Secondly, distal end anchoring 200 passes through the distal end of acicular delivery pipe 830, with reference to Fig. 9；Retract acicular delivery pipe 830, so that acicular delivery pipe 830 is removed from distal end anchoring transmission device 820, thus release distal end anchoring 200, with reference to figure 10；Anchoring transmission device 820 in distal end is removed from sheath 810, and adjusts the position of distal end anchoring 200, with reference to Figure 11；Proximal anchor Determine transmission device 840 and advance through sheath 810, so that the distal end of proximal end anchoring transmission device 840 is from the distal end of sheath 810 Out.Before the distal end that proximal end is anchored transmission device 840 comes out from the distal end of sheath 810, connector 300 can be made to be placed through closely Proximal end anchoring 100 in end anchoring transmission device 840, connector 300 and proximal end are anchored 100 still in isolated state at this time, The position of 300 opposite proximal end of connector anchoring 100 can adjust in real time, with reference to Figure 12.

It is again secondary, distally anchoring 200 is pulled by connector 300, distally anchoring 200 and proximal end are anchored between 100 with adjustment Relative position, so that loose prostata tissue be made to shrink；Later, it connect proximal end anchoring 100 with connector 300 so that even Fitting 300 and the position of proximal end anchoring 100 are relatively fixed, and are anchored proximal end anchoring 100 proximally in transmission device 840 and release It puts, thus in the tissue by 100 placement of proximal end anchoring, thus in the tissue by an anchoring device placement, with reference to Figure 13.

Then, according to the actual conditions of patient, aforesaid operations is repeated by other anchoring devices and are implanted into urethra, generally need to plant Enter 4-6 to anchoring device, these anchoring device collective effects are to treat benign prostatic hyperplasis.

Embodiment two

The present embodiment provides a kind of anchoring device, the anchoring device in the present embodiment is to the anchoring device in embodiment one Further improvement.With reference to Figure 14 and Figure 15, Figure 14 and Figure 15 are close in the anchoring device in the embodiment of the present invention two respectively Two kinds of structural schematic diagrams of end anchoring 100, in the present embodiment, the first protrusion 112 includes at least one second groove 113.

Since the first protrusion 112 includes at least one second groove 113.Therefore the thick of contact surface 110 can be further increased Rugosity is anchored the mobile frictional resistance of 100 relative organizations so as to further increase proximal end, and then can further improve proximal anchor Fixed 100 adherent performance reduces the risk that proximal end is anchored the displacement of 100 relative organizations so that the anchorage stability of anchoring device into One step improves；The contact area of contact surface 110 and tissue can also be further increased, is stablized so as to improve the anchoring of anchoring device Property.

Preferably, with reference to Figure 14 and Figure 15, drug 400 is equipped in the second groove 113.Thus it can increase contact surface 110 The area of upper setting drug 400, further improves the therapeutic effect of anchoring device.

Second groove 113 can be U-type groove or V-groove.Second groove 113 can be two adjacent with the first protrusion 112 the The connection of one groove 111 can also be only connected to the first raised 112 adjacent first grooves 111, or with the first protrusion 112 Two adjacent the first grooves 111 form two side protrusions.As shown in Figure 14 and Figure 15, the second groove 113 and the first protrusion 112 adjacent two the first grooves 111 connections.

With reference to Figure 14 and Figure 15, multiple continuous second grooves 113 are distributed along the width direction of proximal end anchoring 100.? In other embodiments, the length direction that multiple continuous second grooves 113 can also be anchored 100 along proximal end is distributed, or any Directional spreding.

Preferably, the shapes and sizes of multiple second grooves 113 are all the same, and multiple continuous second grooves 113 are along close The width direction of end anchoring 100 is uniformly distributed, and can be processed convenient for the second groove 113.Second groove 113 can be added by Passivation Treatment The modes machine-shapings such as work, annular knurl processing, laser processing, electrical discharge machining.

Preferably, the first protrusion 112 further includes at least one second protrusion 114, and the second protrusion 114 is arranged in the second groove 113 two sides.In this way, the roughness of the contact surface 110 of proximal end anchoring 100 can be further enhanced, the patch of proximal end anchoring 100 is improved Wall performance reduces the risk that proximal end is anchored the displacement of 100 relative organizations, so that the anchorage stability of anchoring device improves.

Further, the second protrusion 114 has at least one tip.In this way, working as the tip piercing group of each second protrusion 114 When knitting, the drug 400 in the first groove 111 and the second groove 113 is also easier to penetrate into tissue, 111 He of the first groove Drugloading rate in second groove 113 can be reduced accordingly, and the validity of drug 400 can improve, while cost is reduced, can be maximum Improve to degree the utilization rate of drug 400.Meanwhile the roughness of the contact surface 110 of proximal end anchoring 100 can be further enhanced, it mentions The adherent performance of high proximal end anchoring 100, reduces the risk that proximal end is anchored the displacement of 100 relative organizations, improves the anchoring of anchoring device Stability.

Drug 400 is also provided in the present embodiment in second groove 113, is also provided on further drug 400 Protective layer 500, specific set-up mode is identical as the set-up mode of drug 400 and protective layer 500 in embodiment one, no longer superfluous herein It states.

Embodiment three

The present embodiment provides a kind of anchoring devices.Anchoring device in the present embodiment and the anchoring device in embodiment one Difference is, is that a kind of structure of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention three is shown with reference to Figure 16, Figure 16 It is intended to, in the present embodiment, recessed portion includes the multiple third grooves 115 being arranged on contact surface 110.

As shown in figure 16, multiple third grooves 115 are in spot distribution.Third groove 115 is in cutting perpendicular to contact surface 110 Shape on face can be V-type, U-shaped or rectangle.Shape of the third groove 115 on the section for being parallel to contact surface 110 be It is round.In other embodiments, shape of the third groove 115 on the section for being parallel to contact surface 110 can be ellipse.It is excellent Choosing, multiple third grooves 115 are uniformly distributed, can be easy to process.

Drug 400 can be accommodated in third groove 115.After anchoring device is fixed in the tissue, 400 pairs of groups of drug can be passed through It knits and is treated, the drug 400 being arranged in recessed portion can realize Targeting delivery, also can avoid urethra to the long-term of drug 400 It washes away and affects the treatment, further improve the therapeutic effect of anchoring device, can also be reduced while playing identical therapeutic effect Drugloading rate.

Drug 400 and protective layer 500 can also be provided in third groove 115 in the present embodiment, specific set-up mode and reality Apply in example one that drug 400 is identical with the set-up mode of protective layer 500, details are not described herein.

Contact surface 110 further includes multiple third protrusion (not shown), and the week of third groove 115 is arranged in third protrusion It encloses.In this way, third protrusion can further increase the roughness of contact surface 110, the adherent performance of proximal end anchoring 100 is improved, is reduced Proximal end is anchored the risk of 100 relative organizations displacement, so that the anchorage stability of anchoring device improves.Specifically, third protrusion is certainly The edge of third groove 115 is extended.

Further, third protrusion has at least one tip.

Example IV

The present embodiment provides a kind of anchoring devices.Anchoring device in the present embodiment and the anchoring device in embodiment one Difference is, is that a kind of structure of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention four is shown with reference to Figure 17, Figure 17 It is intended to, in the present embodiment, recessed portion is through proximal end anchoring 100.

Specifically, as shown in figure 17, recessed portion is through-hole 117, and through-hole 117 is through proximal end anchoring 100.Multiple through-holes 117 In spot distribution.Shape of the through-hole 117 on the section for being parallel to contact surface 110 is circle.In other embodiments, through-hole 117 shape on the section for being parallel to contact surface 110 is ellipse.Preferably, multiple through-holes 117 are uniformly distributed, and can be convenient for Processing.

Drug 400 can be accommodated in through-hole 117 (with reference to the recessed portion in Figure 17).When anchoring device is fixed in the tissue Afterwards, it can be treated by 400 pairs of tissues of drug, the drug 400 being arranged in recessed portion can realize Targeting delivery, also can avoid Urethra affects the treatment to washing away for a long time for drug 400, further improves the therapeutic effect of anchoring device, is playing identical treatment Drugloading rate can also be reduced while effect.

In the present embodiment, anchoring device further includes protective layer 500, and protective layer 500 is arranged in through-hole 117, and is covered on On two outer surfaces of inner wall of the drug 400 far from through-hole 117.Since protective layer 500 is arranged in through-hole 117, and it is covered on On the outer surface of inner wall of the drug 400 far from through-hole 117, therefore the speed of the loss of drug 400 can be slowed down, improve drug 400 Release conditions when there is the substance of flowing especially around anchoring device, can avoid these flowings so as to improve therapeutic effect Substance directly wash away drug 400, cause drug 400 be lost, influence therapeutic effect.

Preferably, contact surface 110 further includes multiple 4th protrusions, and the 4th protrusion is arranged in around through-hole 117.Specifically , the 4th protrusion is extended from the edge of through-hole 117.

Further, the 4th protrusion has at least one tip.

Embodiment five

The present embodiment provides a kind of anchoring devices.Anchoring device in the present embodiment and the anchoring device in embodiment one Difference is, is that a kind of structure of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention five is shown with reference to Figure 18, Figure 18 It is intended to, in the present embodiment, recessed portion includes multiple 4th grooves 118 being arranged on contact surface 110.

As shown in figure 18, multiple 4th grooves 118 are distributed along the length direction of proximal end anchoring 100.4th groove 118 exists It is V-type, U-shaped or rectangle perpendicular to the shape on the section of contact surface 110.4th groove 118 is being parallel to contact surface 110 Shape on section is waveform.In other embodiments, shape of the 4th groove 118 on the section for being parallel to contact surface 110 Shape can be serrated.

Preferably, multiple 4th grooves 118 are uniformly distributed, can be easy to process.

With reference to Figure 18, drug 400 can be accommodated in the 4th groove 118.After anchoring device is fixed in the tissue, it can pass through 400 pairs of tissues of drug are treated, and the drug 400 being arranged in recessed portion can realize Targeting delivery, also can avoid urethra to medicine Washing away for a long time for object 400 affects the treatment, and further improves the therapeutic effect of anchoring device, is playing the same of identical therapeutic effect When can also reduce drugloading rate.

Drug 400 and protective layer 500 can also be provided in the 4th groove 118 in the present embodiment, specific set-up mode and reality Apply in example one that drug 400 is identical with the set-up mode of protective layer 500, details are not described herein.In other examples, the 4th is recessed It the bottom of slot 118 can be through proximal end anchoring 100, to form wavy through-hole 117 in proximal end anchoring 100.

Preferably, contact surface 110 further includes multiple 5th protrusions, and the 5th protrusion is arranged in around the 4th groove 118.Tool Body, the 5th protrusion is extended from the edge of the 4th groove 118.

Further, the 5th protrusion has at least one tip.

Embodiment six

The present embodiment provides a kind of anchoring devices.With reference to the anchoring that Figure 19 and Figure 20, Figure 19 are in the embodiment of the present invention six The structural schematic diagram of device, Figure 20 are the schematic diagram of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention six, anchoring Device includes proximal end anchoring 100, distal end anchoring 200 and connector 300.

With reference to Figure 19 and Figure 20, proximal end anchoring 100 includes the first clamping part 120, the second clamping part 130, the first shrapnel part 140 and second shrapnel part 150.Wherein, the first clamping part 120 has the first fixing end and the first free end, the second clamping part 130 With the second fixing end and the second free end, the first shrapnel part 140 has third fixing end and third free end, the second shrapnel part 150 have the 4th fixing end and the 4th free end.The third of first fixing end of the first clamping part 120 and the first shrapnel part 140 Fixing end is fixedly connected, and the second fixing end of the second clamping part 130 is fixedly connected with the 4th fixing end of the second shrapnel part 150. First fixing end of the first clamping part 120 is connected with the second fixing end of the second clamping part 130.The proximal end of connector 300 and the One clamping part 120 and the second clamping part 130 are selectively connected.The distal end of connector 300 is fixedly connected with distal end anchoring 200. When the proximal end of connector 300 is connect with the first clamping part 120 and the second clamping part 130, the first clamping part 120 and the second clamping 130 holding attachment 300 of portion.

Figure 21 is the stress analysis schematic diagram of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention six, is such as schemed Shown in 21, when the proximal end of connector 300 is connect with the first clamping part 120 and the second clamping part 130,120 He of the first clamping part One end of second clamping part, 130 holding attachment 300, therefore the first clamping part 120 and the second clamping part 130 are to connector 300 A chucking power F1 can be applied with holding attachment 300, corresponding connector 300 applies one and folder to proximal end anchoring 100 Holding force F1 opposite reaction force F2.The free end of the first clamping part 120 and the second clamping part under the action of reaction force F2 It opens 130 free end.Since the first shrapnel part 140 extends from one end of the first clamping part 120, the second shrapnel part 150 is from the One end of two clamping parts 130 extends, and the first clamping part 120 is fixedly connected with one end of the second clamping part 130, and the first shrapnel part 140 and second shrapnel part 150 all have free end, therefore under the action of reaction force F2, the first shrapnel part 140 and the second bullet Piece portion 150 is close to each other, and deformation occurs, especially the free end of the free end of the first shrapnel part 140 and the second shrapnel part 150, phase The first shrapnel part 140 answered and the second shrapnel part 150 generate restoring force F3 to restore deformation, and restoring force F3 can reduce the first clamping The degree that portion 120 and the free end of the second clamping part 130 are opened, so as to make the first clamping part 120 and the second clamping part 130 with The connection of connector 300 is more firm, and the stability of anchoring device can be improved.

With reference to Figure 21, the first clamping part 120 and the second clamping part 130 are integrated.First clamping part 120 and the second clamping Portion 130 is connected as one at the first fixing end of the first clamping part 120 and the second fixing end of the second clamping part 130, and first Spacing between clamping part 120 and the second clamping part 130 from the first fixing end of the first clamping part 120 to the first free end gradually Become larger.It is formed for example, the first clamping part 120 and the second clamping part 130 such as can be cut by laser at the modes.When connector 300 from Gradually the consolidating to the first clamping part 120 that be open between the free end of first clamping part 120 and the free end of the second clamping part 130 When opening between fixed end and the fixing end of the second clamping part 130 is mobile, i.e., connector 300 be proximally anchored 100 outside to When the inside of proximal end anchoring 100 is mobile, clamping force that the first clamping part 120 and the second clamping part 130 apply connector 300 by Gradual change is big, consequently facilitating connector 300 is assembled into the first clamping part 120 and the second clamping part 130.

It is another signal of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention six with reference to Figure 22, Figure 22 Figure, the first clamping part 120 and the second clamping part 130 are integrated.First clamping part 120 and the second clamping part 130 are in the first folder It holds and is connected as one at first fixing end in portion 120 and the second fixing end of the second clamping part 130, the first clamping part 120 and It is equidistant between two clamping parts 130.For example, the first clamping part 120 and the second clamping part 130 can be cut by laser etc. modes at Type.

With reference to Figure 22, one end of close first clamping part 120 and part first clamping part opposite with the second clamping part 130 The first sawtooth 121 is provided on 120, one end of close second clamping part 130 and the part second opposite with the first clamping part 120 It is provided with the second sawtooth 131 on clamping part 130, the first sawtooth 121 and the second sawtooth 131 are symmetrical arranged, and can further improve the The connective stability of one clamping part 120 and the second clamping part 130 and connector 300.

Specifically, the first sawtooth 121 is corresponding with the teeth portion of the second sawtooth 131, between the teeth portion of the first sawtooth 121 between Gap between gap and the teeth portion of the second sawtooth 131 is corresponding.

Preferably, with reference to Figure 22, the junction circular arc of one end of the first clamping part 120 and one end of the second clamping part 130 Transition, the stress that can reduce junction are concentrated.

Proximal end anchoring 100 can be metal material or high molecular material, the material of proximal end anchoring 100 can for degradable material or Non-degradable material.

In the present embodiment, as shown in figure 19, the contact surface 110 of proximal end anchoring 100 is located at the first clamping part 120, second folder It holds in portion 130, the first shrapnel part 140 and the second shrapnel part 150 on the side of the proximal end of connector 300.

In the present embodiment, the process of anchoring device implanting tissue be can refer into embodiment one.Wherein, anchoring device is implanted into During tissue, when connector 300 is placed through the proximal end anchoring 100 in proximal end anchoring transmission device 840, it can will connect Part 300 is placed in the opening between the other end of the first clamping part 120 and the second clamping part 130；Make proximal end anchoring 100 with connect Part 300 connects and when fixing, can be by connector 300 from the other end of the first clamping part 120 and the other end of the second clamping part 130 Between opening it is gradually mobile to the opening between one end of the first clamping part 120 and one end of the second clamping part 130, even if even The inside that the outside that fitting 300 is proximally anchored 100 is proximally anchored 100 is mobile, the first clamping part 120 and the second clamping part The clamping force that 130 pairs of connectors 300 apply becomes larger, so that the first clamping part 120 and the second clamping part 130 be made to clamp connection Part 300 realizes the connection and fixation of the first clamping part 120 and the second clamping part 130 with connector 300.

Embodiment seven

The present embodiment provides a kind of anchoring devices.It is in the anchoring device in the embodiment of the present invention seven with reference to Figure 23, Figure 23 Proximal end anchoring 100 schematic diagram, the difference of anchoring device and the anchoring device in embodiment six in the present embodiment is, the One sawtooth 121 is staggered with the second sawtooth 131.

One end and the part opposite with the second clamping part 130 the specifically, with reference to Figure 23, close to the first clamping part 120 The first sawtooth 121 is provided on one clamping part 120, close to one end of the second clamping part 130 and opposite with the first clamping part 120 The second sawtooth 131 is provided on the second clamping part of part 130, the teeth portion of the first sawtooth 121 and the teeth portion of the second sawtooth 131 are interlocked It is arranged, the gap between the teeth portion of the first corresponding sawtooth 121 and the gap between the teeth portion of the second sawtooth 131 are staggeredly set It sets.

Embodiment eight

The present embodiment provides a kind of anchoring devices.It is in the anchoring device in the embodiment of the present invention eight with reference to Figure 24, Figure 24 Proximal end anchoring 100 cross-sectional view, the difference of anchoring device and the anchoring device in embodiment six in the present embodiment is, anchor Determine 130 split settings of the first clamping part 120 and the second clamping part in device, anchoring device further includes fixing piece 600, fixing piece 600 are fixedly connected with the second fixing end of the first fixing end of the first clamping part 120 and the second clamping part 130 respectively.In this way, can Enhance the first shrapnel part 140 and the second shrapnel part 150 to restore the restoring force F3 of deformation generation, makes 120 He of the first clamping part The connective stability of second clamping part 130 and connector 300 is further promoted, and can also make the processing of proximal end anchoring 100 more Simply.

As shown in figure 24, distinguish in the first fixing end of the first clamping part 120 and the second fixing end of the second clamping part 130 It is provided with opposite the first installation through-hole 122 and the second installation through-hole 132, fixing piece 600 passes through the first installation through-hole 122 and the Two installation through-holes 132 are simultaneously fixedly connected with the first clamping part 120 and the second clamping part 130.The first of first clamping part 120 is fixed End is fixedly connected with the second fixing end of the second clamping part 130 by fixing piece 600.

In the present embodiment, fixing piece 600 be cylindrical pin, fixing piece 600 respectively with the first clamping part 120 and the second clamping part 130 welding.In other embodiments, fixing piece 600 can also be other shapes of pin, and fixing piece 600 can also pass through the side of riveting Formula is fixedly connected with the first clamping part 120 and the second clamping part 130 respectively；Fixing piece 600 can also be fastener, for example, screw Or bolt etc..

Embodiment nine

The present embodiment provides a kind of anchoring device, the anchoring device in the present embodiment is the anchoring device in embodiment six It is further improved.It is the schematic diagram of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention nine with reference to Figure 25, Figure 25, In the present embodiment, the first shrapnel part 140 reinforces teeth 141 towards being extended with multiple first on the direction of the second shrapnel part 150, and second Shrapnel part 150 reinforces teeth 151 towards being extended with multiple second on the direction of the first shrapnel part 140, and multiple first reinforce 141 Hes of tooth Multiple second reinforcement teeth 151 are oppositely arranged, when the proximal end of connector 300 is connect with the first clamping part 120 and the second clamping part 130 When, the first reinforcement tooth 141 and the second reinforcement tooth 151 contact with each other.When the proximal end of connector 300 and the first clamping part 120 and the When two clamping parts 130 connect, the first shrapnel part 140 and the second shrapnel part 150 hair close to each other under the action of reaction force F2 Raw deformation, since the first reinforcement tooth 141 and the second reinforcement tooth 151 contact with each other, the first shrapnel part 140 and the second shrapnel part The restoring force F3 of 150 generations is stronger, to keep the connection of the first clamping part 120 and the second clamping part 130 and connector 300 more steady Gu and then improving the stability of anchoring device.

Embodiment ten

The present embodiment provides a kind of anchoring device, the anchoring device in the present embodiment is the anchoring device in embodiment six It is further improved.It is the schematic diagram of the proximal end anchoring 100 in the anchoring device in the embodiment of the present invention ten with reference to Figure 26, Figure 26, In the present embodiment, anchoring device includes at least one elastic element 700, and the setting of elastic element 700 is in the first shrapnel part 140 and the Between two shrapnel parts 150, when the proximal end of connector 300 is connect with the first clamping part 120 and the second clamping part 130, elasticity member Part 700 is in compressive state.When the proximal end of connector 300 is connect with the first clamping part 120 and the second clamping part 130, first Shrapnel part 140 and the second shrapnel part 150 it is close to each other under the action of reaction force F2 deformation occurs, due to elastic element 700 In compressive state, therefore the restoring force F3 that the first shrapnel part 140 and the second shrapnel part 150 can be made to generate is stronger, to make the The connection of one clamping part 120 and the second clamping part 130 and connector 300 is more firm, and then improves the stability of anchoring device.

As shown in figure 26, elastic element 700 is spring, and one end of elastic element 700 is connect with the first shrapnel part 140, bullet The other end of property element 700 is connect with the second shrapnel part 150.Elastic element 700 can pass through the modes such as binder or welding and the One shrapnel part 140 is fixedly connected with the second shrapnel part 150.The quantity of elastic element 700 can be four, in other embodiments, The quantity of elastic element 700 can also be two, three etc., and details are not described herein.Elastic element 700 can also for elastic slice etc. other Element with preferable elasticity.In other embodiments, elastic element 700 can be with the first shrapnel part 140 and the second shrapnel part 150 It is integrally formed.

Embodiment 11

The present embodiment provides a kind of anchoring devices.With reference to the anchor that Figure 27 and Figure 28, Figure 27 are in the embodiment of the present invention 11 Determine the structural schematic diagram of device, Figure 28 is the cross-sectional view of one of the embodiment of the present invention 11 anchoring device, anchoring device packet Include proximal end anchoring 100, distal end anchoring 200 and connector 300.Distal end anchoring 200 includes anchoring body 210 in a tubular form, and The bending part 220 for extending and bending from one end of anchoring body 210 can be conducive to by setting bending part 220 by distal end anchoring 200 It is fixed on organization internal, reduces the risk that portion shifts within the organization of distal end anchoring 200.Distal end anchoring 200 can for metal material or The material of person's high molecular material, distal end anchoring 200 can be degradable material or non-degradable material.

Connector 300 includes first connecting portion and the second connecting portion extended from one end of first connecting portion, and first The inside N of the lumen of anchoring body 210 is arranged in interconnecting piece, and the outside of the lumen of anchoring body 210 is arranged in second connecting portion W, second connecting portion are selectively connected with proximal end anchoring 100, and first connecting portion includes multiple fixed grooves 310, anchoring body 210 tube wall is extended with multiple limit recessed portions 211 to match with fixed groove 310 to N inside lumen.

Since first connecting portion includes multiple fixed grooves 310, the tube wall of anchoring body 210 extends to the inside N of lumen There are multiple limit recessed portions 211 to match with fixed groove 310, therefore can avoid connector 300 along anchoring body 210 The axial movement of lumen and Relative anchor main body 210 rotate, thus improve distal end anchoring 200 and connector 300 connect it is steady It is qualitative, and then improve the stability of anchoring device.

Multiple fixed grooves 310 and the limit recessed portion 211 to match with fixed groove 310 can be by way of extruding Molding, that is, be press-connected first connecting portion with anchoring body 210, and form multiple fixed grooves in first connecting portion 310, multiple limit recessed portions 211 extended to the inside N of lumen are formed on the tube wall of anchoring body 210.

With reference to Figure 27 and Figure 28, section of the recessed portion 211 on the direction extended into the lumen of anchoring body 210 is limited Shape be semicircle, in other examples, limit recessed portion 211 in the side extended into the lumen of anchoring body 210 The shape in upward section can be U-shaped.

Further, the other end of first connecting portion is extended with a limiting section 320, and limiting section 320 is for limiting the first company Socket part is skidded off from the inside N of the lumen of anchoring body 210.Since limiting section 320 is for limiting first connecting portion from anchoring body The inside N of 210 lumen is skidded off, therefore can limit connector 300 along the axial movement of the lumen of anchoring body 210, thus The stability of distal end anchoring 200 and the connection of connector 300 is further increased, and then improves the stability of anchoring device.Connector 300 and distal end anchoring 200 during connection, can be first by the other end of first connecting portion from the lumen of anchoring body 210 One end penetrates to be pierced by from the other end of the lumen of anchoring body 210 again, and the distal end of connector 300 is made to have a limiting section again later 320.When connector 300 is in the shape of a rod, the distal end of connector 300 can be made compared with the lumen of anchoring body 210 by modes such as extruding Slightly, to form a limiting section 320.When connector 300 is in rope form, the distal end of connector 300 can be made by the modes such as tie knots Lumen compared with anchoring body 210 is thick, to form a limiting section 320.

As shown in figure 27, the angle between the axial direction of the lumen of bending part 220 and anchoring body 210 is between 0-90 °, such as This can reduce the risk that portion shifts within the organization of distal end anchoring 200 convenient for distally anchoring 200 is fixed on organization internal.Bending Portion 220 can be the laminated structure extended from the opening of one end of anchoring body 210.

Specifically, bending part 220 includes changeover portion 221 and bending segment 222, one end and the anchoring body 210 of changeover portion 221 One end connection, the other end of changeover portion 221 connect with one end of bending segment 222, and the other end of bending segment 222 is free end. As shown in figure 27, the angle between the axial direction of the lumen of bending segment 222 and anchoring body 210 is between 0-90 °.Changeover portion 221 The sides of side extensions and bending segment 222 be smoothly connected.

Figure 29 is the signal being distally anchored in anchoring device on 200 in the embodiment of the present invention 11 when being provided with drug 400 Figure, with reference to Figure 29, anchoring device further includes drug 400, and the setting of drug 400 is in limit recessed portion 211.When anchoring device is fixed It after in the tissue, can be treated by 400 pairs of tissues of drug, the drug 400 being arranged in limit recessed portion 211 can realize target To release, the substance that also can avoid flowing washes away drug 400 for a long time and affects the treatment, and further improves the treatment effect of anchoring device Fruit can also reduce drugloading rate while playing identical therapeutic effect.

Drug 400 can be anti-cell proliferation agents 400, such as rapamycin, taxol, Zuo Tamosi, everolimus Deng.When being used to treat benign prostatic hyperplasis in anchoring device implantation urethra, the drug 400 in anchoring device can inhibit forefront The further hyperplasia of gland, so as to reduce urethra restenosis problem caused by hyperplasia of prostate after anchoring device is implanted into.Drug 400 can Directly it is arranged in limit recessed portion 211 by spraying or in such a way that drug 400 recrystallizes.

Further, distal end, which is anchored on other outer surfaces that 200 remove contact surface 110, may also set up drug 400.Distal anchor Except on other outer surfaces at limit recessed portion 211 and can also on the outer surface of connector 300 on fixed 200 contact surface 110 It is provided with drug 400.

Further, anchoring device further includes protective layer 500, and the setting of protective layer 500 is covered in limit recessed portion 211 It covers on the outer surface in side of the drug 400 far from limit recessed portion 211.

With reference to Figure 27, connector 300 is L-shaped, and first connecting portion is bent with respect to second connecting portion.Connector 300 and proximal end Anchoring 100 can be assembled and be connected during being implanted to corresponding tissue.Anchoring device implantation after the completion of, connector 300 with The position of proximal end anchoring 100 is relatively fixed.

Connector 300 can be that perhaps high molecular material metal material or high molecular material can also be that can drop to metal material Solution or non-degradable material.Connector 300 can be in rope form or rod-shaped.In the present embodiment, by the process of anchoring device implanting tissue It can refer to embodiment one, details are not described herein.

Embodiment 12

The present embodiment provides a kind of anchoring devices.It is in the embodiment of the present invention 12 in anchoring device with reference to Figure 30, Figure 30 Distal end anchoring 200 is equipped with schematic diagram when drug 400, and the anchoring device in the present embodiment and the anchoring in embodiment 11 fill The difference set is that the shape for limiting section of the recessed portion 211 on the direction extended into the lumen of anchoring body 210 is ladder Shape.

Embodiment 13

The present embodiment provides a kind of anchoring devices.It is in the embodiment of the present invention 13 in anchoring device with reference to Figure 31, Figure 31 Distal end anchoring 200 is equipped with schematic diagram when drug 400, and the anchoring device in the present embodiment and the anchoring in embodiment 11 fill The difference set is that the shape for limiting section of the recessed portion 211 on the direction extended into the lumen of anchoring body 210 is V Type.

Embodiment 14

The present embodiment provides a kind of anchoring devices.It is in the embodiment of the present invention 14 in anchoring device with reference to Figure 32, Figure 32 Distal end anchoring 200 is equipped with schematic diagram when drug 400, and the anchoring device in the present embodiment and the anchoring in embodiment 11 fill The difference set is, in the present embodiment, the radial section of the part of the inside N of the lumen of anchoring body 210 is arranged in connector 300 Size change along the axis of anchoring body 210, the inner surface of the lumen of anchoring body 210 and connector 300 are arranged in anchor The outer surface for determining the part of the inside N of the lumen of main body 210 matches.

By make connector 300 be arranged in anchoring body 210 lumen inside N part radial section size edge Anchoring body 210 axis variation, and make anchoring body 210 lumen inner surface and connector 300 be arranged be anchored The outer surface of the part of the inside N of the lumen of main body 210 matches, and can limit connector 300 in the lumen of anchoring body 210 It is moved along the axis of the lumen of anchoring body 210, the distal end that can reduce connector 300 enters the lumen of anchoring body 210 The risk of internal N, to improve the stability of distal end anchoring 200 and the connection of connector 300.

Embodiment 15

The present embodiment provides a kind of anchoring device, the anchoring device in the present embodiment is to the anchoring dress in embodiment 11 The further improvement set.It is the schematic diagram of the distal end anchoring 200 in the embodiment of the present invention 15 with reference to Figure 33, Figure 33, with Figure 27 It compares, in Figure 27, the side of bending segment 222 is connected with the side of changeover portion 221, and junction connects in smooth transition It connects, namely in the not formed any notch in the side of bending segment 222 and the side junction of changeover portion 221, and in the present embodiment, it is curved The junction of the side of the side and changeover portion 221 of trisection 222 forms at least one notch, for so that bending segment 222 it is rigid Degree is less than the rigidity with changeover portion 221, and in Figure 33, which is formed by the inclined surface of 221 distal end two sides of changeover portion, but ability Technical staff in domain can know that the notch is also possible to the face being made of arcwall face, cascaded surface or other curves and/or straight line To be formed.Since the junction of bending segment 222 and changeover portion 221 forms notch, the rigidity of bending segment 222 is less than and changeover portion 221 rigidity, the bonding strength between bending segment 222 and changeover portion 221 die down, and after distal end is anchored 200 implanting tissues, work as bending End 222 with tissue it is mobile when, changeover portion 221 is not easy to move with the movement of bending end 222, so as to reduce distal anchor The fixed risk being integrally displaced, when changeover portion 221 is mobile, bending end 222 is not easy to move with the movement of changeover portion 221 It is dynamic, so as to reduce the risk that portion shifts within the organization of bending end 222.

Specifically, as shown in figure 33, the notch that the side of bending segment 222 and the side junction of changeover portion 221 open up 223 include the first notch and the second notch.First notch and the second notch are respectively arranged on two sides of changeover portion 221.

When distal end anchoring molding, the bending segment 222 of bending part, can be first curved before opposite changeover portion 221 is bent Two notches are processed on two sides of the junction of trisection 222 and changeover portion 221.The bending segment 222 of bending part is opposite After changeover portion 221 is bent and is formed, two notches are respectively above-mentioned the first notch and the second notch.

Foregoing description is only the description to present pre-ferred embodiments, not to any restriction of the scope of the invention, this hair Any change, the modification that the those of ordinary skill in bright field does according to the disclosure above content, belong to the protection of claims Range.

Claims

1. a kind of anchor log, which is characterized in that including contact surface and non-contact face, the contact surface is used for and a tissue phase mutual connection Touching, the contact surface includes at least one recessed portion and/or at least one lug boss.

2. anchor log as described in claim 1, which is characterized in that further include drug, the medicine is equipped in the recessed portion Object.

3. anchor log as claimed in claim 2, which is characterized in that further include protective layer, the protective layer is covered on the medicine On object.

4. anchor log as described in claim 1, which is characterized in that the lug boss has at least one tip.

5. anchor log as described in claim 1, which is characterized in that the recessed portion includes at least one first groove, described First groove is continuously arranged along the first predetermined direction.

6. anchor log as claimed in claim 5, which is characterized in that the lug boss further includes at least one first protrusion, institute The first protrusion is stated to be staggered along the orientation of multiple first grooves with multiple first grooves.

7. anchor log as claimed in claim 6, which is characterized in that first protrusion includes at least one second groove, institute The second groove is stated continuously to be arranged along the second predetermined direction.

8. anchor log as claimed in claim 7, which is characterized in that first protrusion further includes at least one second protrusion, The two sides of second groove are arranged in second protrusion.

9. anchor log as described in claim 1, which is characterized in that the recessed portion includes at least one third groove, described Third groove is a through-hole and/or blind hole in spot distribution and/or the third groove.

10. anchor log as described in claim 1, which is characterized in that the recessed portion includes at least one the 4th groove, described Length direction distribution and/or fourth groove of 4th groove along the anchor log are waveform and/or zigzag.

11. anchor log as described in claim 1, which is characterized in that for being selectively connected with connector, the anchor log It further include the first clamping part, the second clamping part, the first shrapnel part and the second shrapnel part, first clamping part has first to fix End and the first free end, second clamping part have the second fixing end and the second free end, and first shrapnel part has the Three fixing ends and third free end, second shrapnel part have the 4th fixing end and the 4th free end, first clamping part The first fixing end be fixedly connected with the third fixing end of first shrapnel part, the second fixing end of second clamping part with 4th fixing end of second shrapnel part is fixedly connected, the first fixing end of first clamping part and second clamping part The connection of the second fixing end, the connector is selectively connected with first clamping part and second clamping part；

When the connector is connect with first clamping part and second clamping part, first clamping part and the second folder It holds portion and clamps the connector.

12. a kind of anchoring device, which is characterized in that including distal end anchoring, connector and such as any one of claim 1 to 11 institute The anchor log stated, the connector are selectively connected with the anchor log, the connector and the fixed company of distal end anchoring It connects.