CN210095992U - Anchor and anchoring device - Google Patents

Abstract

The utility model provides an anchor and anchoring device. The anchor is for selective connection with a connecting member, the anchor including a first clip portion, a second clip portion, a first tab portion, and a second tab portion. The first fixed end of the first clamping part is fixedly connected with the third fixed end of the first elastic sheet part, the second fixed end of the second clamping part is fixedly connected with the fourth fixed end of the second elastic sheet part, the first fixed end of the first clamping part is connected with the second fixed end of the second clamping part, and the connecting piece is selectively connected with the first clamping part and the second clamping part; when the connecting piece is connected with the first clamping part and the second clamping part, the first clamping part and the second clamping part clamp the connecting piece. The utility model discloses in the anchoring member is firm with being connected of connecting piece, and anchoring device's stability is high.

Description

Anchor and anchoring device

Technical Field

The utility model relates to the technical field of medical equipment, in particular to anchoring piece and anchoring device.

Background

Benign prostatic hyperplasia is one of the most common benign diseases causing urination disorders in middle-aged and elderly men. It is mainly manifested by the hyperplasia of interstitial and glandular components of prostate gland in histology, enlargement of prostate gland in anatomy, clinical symptoms such as lower urinary tract symptoms and urinary bladder outlet obstruction.

Besides drug treatment, there are several surgical approaches for benign prostatic hyperplasia: (1) transurethral resection of the prostate; (2) suprapubic or retropubic prostatectomy; (3) laser enucleation or resection of the prostate; (4) minimally invasive wound treatment including prostate stent.

Prostate stents generally employ an anchoring device, which is a permanent implant for attenuating small urinary streams, in the treatment of minimally invasive wounds. The anchoring device is implanted into the urethra through the delivery system, and after implantation, the left and right lobes of the prostate are mechanically separated to push the prostate tissue pressing the urethra away, thereby achieving the therapeutic effect. The anchoring device is extremely low in invasiveness, ablation is not needed, symptoms of a patient can be continuously relieved, and the treatment effect is good.

Currently, anchoring devices generally comprise a distal anchor, a proximal anchor and a connector, which is connected to the distal anchor and the proximal anchor, respectively. There is a risk of displacement of such anchoring devices after implantation, and the effectiveness and stability of the treatment needs to be improved.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an anchor and anchoring device to solve the problem that current anchor and anchoring device shift easily after implanting.

In order to solve the above technical problems, the present invention provides an anchor for selectively connecting with a connecting member, comprising a first holding portion, a second holding portion, a first spring piece portion and a second spring piece portion, the first clamping part is provided with a first fixed end and a first free end, the second clamping part is provided with a second fixed end and a second free end, the first spring plate part is provided with a third fixed end and a third free end, the second spring plate part is provided with a fourth fixed end and a fourth free end, the first fixed end of the first clamping part is fixedly connected with the third fixed end of the first elastic sheet part, the second fixed end of the second clamping part is fixedly connected with the fourth fixed end of the second elastic sheet part, a first fixed end of the first clamping part is connected with a second fixed end of the second clamping part, and the connecting piece is selectively connected with the first clamping part and the second clamping part; when the connecting piece is connected with the first clamping part and the second clamping part, the first clamping part and the second clamping part clamp the connecting piece.

Optionally, the first clamping portion and the first elastic sheet portion are integrally formed, and/or the second clamping portion and the second elastic sheet portion are integrally formed, and/or the first clamping portion and the second clamping portion are integrally formed.

Optionally, the clamping device further comprises a fixing piece, and one end of the first clamping portion and one end of the second clamping portion are respectively and fixedly connected with the fixing piece.

Optionally, the first elastic sheet portion extends in a direction towards the second elastic sheet portion to form a plurality of first reinforcing teeth, the second elastic sheet portion extends in a direction towards the first elastic sheet portion to form a plurality of second reinforcing teeth, the first reinforcing teeth and the second reinforcing teeth are arranged oppositely, and when the connecting piece is connected with the first clamping portion and the second clamping portion, the first reinforcing teeth and the second reinforcing teeth are in contact with each other.

Optionally, the elastic element is disposed between the first elastic sheet portion and the second elastic sheet portion, and when the connecting piece is connected with the first clamping portion and the second clamping portion, the elastic element is in a compressed state.

Optionally, the distance between the first clamping portion and the second clamping portion gradually increases from the first fixed end to the first free end.

Optionally, be close to the first stiff end of first clamping part and with the relative part of second clamping part be provided with first sawtooth on the first clamping part, be close to the second stiff end of second clamping part and with the relative part of first clamping part be provided with the second sawtooth on the second clamping part.

Optionally, the first saw teeth and the second saw teeth are symmetrically arranged or staggered.

The utility model also provides an anchoring device, including distal end anchor, connecting piece and foretell anchor, the connecting piece with the anchor is connected selectively, the connecting piece with distal end anchor fixed connection.

Optionally, the distal anchor includes a tubular anchor main body and a bending portion extending from one end of the anchor main body and bending, the connecting member includes a first connecting portion and a second connecting portion extending from one end of the first connecting portion, the first connecting portion is disposed in the lumen of the anchor main body, the second connecting portion is selectively connected to the anchor, the first connecting portion includes a plurality of fixing grooves, and a plurality of limiting recesses matched with the fixing grooves are formed in the tube wall of the anchor main body extending into the lumen.

Optionally, a drug is disposed at one or more of the outer surface of the limiting recess, the outer surface of the distal anchoring member, the outer surface of the anchoring member, and the outer surface of the connecting member.

The utility model provides a pair of anchoring piece and anchoring device has following beneficial effect:

firstly, because the first fixed end of the first clamping part is fixedly connected with the third fixed end of the first elastic sheet part, the second fixed end of the second clamping part is fixedly connected with the fourth fixed end of the second elastic sheet part, the first fixed end of the first clamping part is connected with the second fixed end of the second clamping part, and the connecting piece is selectively connected with the first clamping part and the second clamping part, when the connecting piece is connected with the first clamping part and the second clamping part, the first clamping part and the second clamping part clamp the connecting piece, therefore, when the connecting piece is connected with the first clamping part and the second clamping part, under the action of the connecting piece, the first elastic sheet part and the second elastic sheet part are close to each other to generate deformation, especially the third free end of the first elastic sheet part and the fourth free end of the second elastic sheet part, the corresponding first elastic sheet part and the second elastic sheet part generate restoring force to restore the deformation, and the restoring force can reduce the degrees of the first free end of the first clamping part and the second free end of the second clamping part, therefore, the connection between the first clamping part and the connecting piece and the connection between the second clamping part and the connecting piece are more stable, the stability of the anchoring device can be improved, and the risk that the anchoring device and the anchoring device are easy to shift after being implanted is reduced.

Secondly, because the one end of first clamping part and the one end components of a whole that can function independently setting of second clamping part in the anchor device, anchor device still includes the mounting, the mounting respectively with the one end of first clamping part and the one end fixed connection of second clamping part, consequently can strengthen first shell fragment portion and second shell fragment portion in order to resume the restoring force that deformation produced, make the stability of being connected of first clamping part and second clamping part and connecting piece further promote, also can make the processing of near-end anchoring simpler.

Thirdly, because first shell fragment portion extends towards the direction of second shell fragment portion has a plurality of first enhancement teeth, and second shell fragment portion extends towards the direction of first shell fragment portion has a plurality of second enhancement teeth, and a plurality of first enhancement teeth and a plurality of second enhancement teeth set up relatively, and when the connecting piece was connected with first clamping part and second clamping part, first enhancement tooth and second enhancement tooth contacted each other. When the connecting piece is connected with first clamping part and second clamping part, first shell fragment portion and second shell fragment portion are close to each other and take place deformation under the effect of connecting piece, because first enhancement tooth and second strengthen the tooth and can contact each other, consequently the restoring force that first shell fragment portion and second shell fragment portion produced is stronger to it is more firm to make being connected of first clamping part and second clamping part and connecting piece, and then improves anchoring device's stability.

And the elastic element is in a compression state when the connecting piece is connected with the first clamping part and the second clamping part, so that the first elastic piece part and the second elastic piece part are close to each other under the action of the connecting piece to deform, and the elastic element is in the compression state, so that the restoring force generated by the first elastic piece part and the second elastic piece part is stronger, the connection between the first clamping part and the connecting piece and the connection between the second clamping part and the connecting piece are firmer, and the stability of the anchoring device is improved.

Drawings

Fig. 1 is a schematic structural view of an anchoring device according to a first embodiment of the present invention;

fig. 2 is a schematic view of a proximal anchor in an anchoring device according to a first embodiment of the present invention;

fig. 3 is a schematic view of a distal end anchor in an anchoring device according to a first embodiment of the present invention;

fig. 4 is another schematic view of a proximal anchor in an anchoring device according to a first embodiment of the present invention;

fig. 5 is a cross-sectional view of a proximal anchoring portion of an anchoring device in accordance with a first embodiment of the present invention;

FIG. 6 is a schematic view of an anchoring device according to one embodiment of the present invention implanted in the urethra;

fig. 7 is a first schematic view of an anchoring device implanted in a urethra in accordance with one embodiment of the present invention;

FIG. 8 is a second schematic view of an anchoring device implanted in a urethra in accordance with one embodiment of the present invention;

FIG. 9 is a third schematic view of an anchoring device implanted in a urethra in accordance with one embodiment of the present invention;

FIG. 10 is a fourth illustration of an anchoring device implanted in a urethra in accordance with a first embodiment of the present invention;

fig. 11 is a fifth illustrative view of an anchoring device implanted in a urethra in accordance with a first embodiment of the present invention;

FIG. 12 is a sixth schematic view of an anchoring device according to a first embodiment of the present invention implanted in the urethra;

fig. 13 is a seventh schematic view of an anchoring device according to a first embodiment of the present invention implanted in the urethra;

fig. 14 is a schematic view of a proximal anchor in the anchoring device according to the second embodiment of the present invention;

fig. 15 is another structural view of the proximal end anchor in the anchoring device according to the second embodiment of the present invention;

fig. 16 is a schematic view of a proximal anchor in an anchoring device according to a third embodiment of the present invention;

fig. 17 is a schematic view of a proximal anchor in an anchoring device according to a fourth embodiment of the present invention;

fig. 18 is a schematic view of a proximal anchor in an anchoring device according to a fifth embodiment of the present invention;

fig. 19 is a schematic structural view of an anchoring device according to a sixth embodiment of the present invention;

fig. 20 is a schematic view of proximal anchoring in an anchoring device according to a sixth embodiment of the present invention;

fig. 21 is a force analysis diagram of proximal anchoring in an anchoring device according to a sixth embodiment of the present invention;

fig. 22 is another illustration of proximal anchoring in an anchoring device according to a sixth embodiment of the present invention;

fig. 23 is a schematic view of proximal anchoring in an anchoring device according to a seventh embodiment of the invention;

fig. 24 is a cross-sectional view of a proximal anchor in an anchoring device according to an eighth embodiment of the present invention;

fig. 25 is a schematic view of proximal anchoring in an anchoring device according to a ninth embodiment of the present invention;

fig. 26 is a schematic view of proximal anchoring in an anchoring device according to a tenth embodiment of the invention;

fig. 27 is a schematic structural view of an anchoring device according to an eleventh embodiment of the present invention;

fig. 28 is a cross-sectional view of an anchoring device in accordance with an eleventh embodiment of the present invention;

figure 29 is a schematic view of an eleventh embodiment of the present invention with a drug disposed on the distal anchor;

figure 30 is a schematic view of a twelfth embodiment of the invention with a drug disposed on the distal anchor;

fig. 31 is a schematic view of a thirteenth embodiment of the present invention, wherein the distal anchor is provided with a drug;

figure 32 is a schematic view of a fourteenth embodiment of the invention with a drug disposed on the distal anchor;

fig. 33 is a schematic view of a distal anchor in accordance with an exemplary fifteen embodiment of the invention.

Detailed Description

The anchor and anchoring device of the present invention will be described in further detail with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become more fully apparent from the following description and appended claims. It should be noted that the drawings are in simplified form and are not to precise scale, and are provided for convenience and clarity in order to facilitate the description of the embodiments of the present invention.

All numerical values herein are assumed to be modified by the term "about," whether or not explicitly indicated. In the context of using numerical values, the term "about" generally refers to a range of values that one of ordinary skill in the art would consider equivalent to the recited value (i.e., having the same function or result). In many instances, the term "about" may include numerical values that are rounded to the nearest significant figure. Unless otherwise specified, other uses of the term "about" (i.e., in contexts other than the use of numerical values) can be assumed to have their ordinary and customary definitions, as can be understood and consistent with the context of this specification.

The "proximal" and "distal" in the above embodiments are relative orientations, relative positions, directions of elements or actions with respect to each other from the perspective of a physician using the medical device, although "proximal" and "distal" are not intended to be limiting, but "proximal" generally refers to the end of the medical device that is closer to the physician during normal operation, and "distal" generally refers to the end that is first introduced into the patient. Furthermore, the term "or" in the above embodiments is generally used in the sense of comprising "and/or" unless otherwise explicitly indicated.

As used in this specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.

Example one

The present embodiment provides an anchoring device. Referring to fig. 1, 2 and 3, fig. 1 is a schematic structural diagram of an anchoring device in a first embodiment of the present invention, fig. 2 and 3 are schematic structural diagrams of a proximal anchor 100 and a distal anchor 200 in an anchoring device in a first embodiment of the present invention, respectively, the anchoring device includes a proximal anchor 100, a distal anchor 200 and a connecting member 300, the proximal anchor 100 includes a contact surface 110 and a non-contact surface, the contact surface 110 is used for contacting with a tissue, the contact surface 110 includes at least one recess and/or at least one protrusion, and the recess or protrusion includes, but is not limited to, a groove, a pattern, a frosted surface, and the like. Connector 300 includes a first connector portion selectively connectable to proximal anchor 100 and a second connector portion extending from an end of the first connector portion fixedly connectable to distal anchor 200.

Since proximal anchor 100 comprises a non-contact surface and a contact surface 110 that is in contact with the tissue, and contact surface 110 comprises at least one recess and/or at least one protrusion, the roughness of contact surface 110 may be greater than the roughness of the non-contact surface, thus improving the adherence performance of proximal anchor 100, reducing the risk of displacement of proximal anchor 100 relative to the tissue, and resulting in improved anchoring stability of the anchoring device.

Specifically, contact surface 110 of proximal anchor 100 includes at least one recess such that the roughness of contact surface 110 is greater than the roughness of the non-contact surface. Since the contact surface 110 of the proximal anchor 100 comprises a plurality of recesses extending from the contact surface 110 to the inside of the proximal anchor 100, the roughness of the contact surface 110 can be increased, so that the frictional resistance of the proximal anchor 100 against the movement of the tissue can be increased, the adherence performance of the proximal anchor 100 can be improved, the risk of displacement of the proximal anchor 100 against the tissue can be reduced, and the anchoring stability of the anchoring device can be improved; the contact area of the contact surface 110 with the tissue may also be increased, thereby improving the anchoring stability of the anchoring device.

Referring to fig. 4, fig. 4 is another schematic structural view of the proximal anchor 100 in the anchoring device according to the first embodiment of the present invention, wherein the recess includes at least one first groove 111, and a plurality of the first grooves 111 are continuously disposed. The first groove 111 may be a U-shaped groove or a V-shaped groove. First groove 111 may communicate with both sides of proximal anchor 100 adjacent to contact surface 110, may communicate with only one side of proximal anchor 100 adjacent to contact surface 110, or may form two lateral protrusions with both sides of proximal anchor 100 adjacent to contact surface 110. Referring to fig. 4, the proximal anchor 100 has an elongated plate shape, and a plurality of first grooves 111 are distributed along the length direction of the proximal anchor 100. In other embodiments, the plurality of first grooves 111 may also be distributed along the width of the proximal anchor 100, or in any direction.

Preferably, and with reference to fig. 4, a plurality of first grooves 111 are evenly distributed along the length of proximal anchor 100 to facilitate machining. The first groove 111 may be formed by a passivation process, a knurling process, a laser process, an electric discharge process, or the like. Proximal anchor 100 may be a metallic material or a polymeric material, and the material of proximal anchor 100 may be a degradable material or a non-degradable material.

Preferably, referring to fig. 5, fig. 5 is a cross-sectional view of a portion of the proximal anchor 100 in the anchoring device according to the first embodiment of the present invention, the anchoring device further includes a drug 400, and the drug 400 is accommodated in the recess (refer to the first groove 111 in fig. 4). After the anchoring device is fixed in the tissue, the tissue can be treated through the medicine 400, the medicine 400 arranged in the concave part can realize targeted release, the long-term washing of the urethra to the medicine 400 can be avoided to influence the curative effect, the treatment effect of the anchoring device is further improved, and the medicine carrying amount can be reduced while the same treatment effect is achieved.

The drug 400 may be an anti-cell proliferation drug 400, such as rapamycin, taxol, zotarolimus, everolimus, and the like. When the anchoring device is implanted in the urethra for the treatment of benign prostatic hyperplasia, the drug 400 in the anchoring device may inhibit further hyperplasia of the prostate, thereby reducing the problem of urethral restenosis caused by prostatic hyperplasia after the anchoring device is implanted. The drug 400 may be disposed in the recess directly by spraying or by recrystallization of the drug.

Further, referring to fig. 5, the anchoring device further includes a protective layer 500, the protective layer 500 being disposed in the recess and covering the drug 400. Therefore, the speed of the loss of the medicine 400 is slowed down, the release condition of the medicine 400 is improved, the treatment effect is improved, and particularly when flowing substances exist around the anchoring device, the phenomenon that the flowing substances directly wash the medicine 400 to cause the loss of the medicine 400 and influence the treatment effect can be avoided.

Further, the drug 400 may be disposed on the outer surface of the proximal anchor 100 other than the contact surface 110. The drug 400 may also be disposed on the contact surface 110 of the proximal anchor 100 on other external surfaces than at the recess and on the external surface of the connector 300.

Preferably, referring to fig. 4, the contact surface 110 further includes a plurality of first protrusions 112, and the first protrusions 112 are staggered with the plurality of first grooves 111 along the length direction. In this way, the first protrusion 112 may further increase the roughness of the contact surface 110, improve the adherence performance of the proximal anchor 100, reduce the risk of displacement of the proximal anchor 100 relative to the tissue, and improve the anchoring stability of the anchoring device.

Preferably, the first protrusion 112 has at least one tip. When the tip of each first protrusion 112 penetrates into the tissue, the drug 400 in the first groove 111 can more easily penetrate into the tissue, the drug loading in the first groove 111 can be correspondingly reduced, the effectiveness of the drug 400 can be improved, and the utilization rate of the drug 400 can be improved to the greatest extent while the cost is reduced. In addition, the tip on the first protrusion 112 may further increase the roughness of the contact surface 110, improve the adherence performance of the proximal anchor 100, reduce the risk of displacement of the proximal anchor 100 relative to the tissue, and improve the anchoring stability of the anchoring device.

Specifically, referring to fig. 1 and 2, the distal anchor 200 includes an anchor body 210, and a bent portion 220 extending and bent from the anchor body 210. The provision of the kink 220 may facilitate fixation of the distal anchor 200 within the tissue, reducing the risk of displacement of the distal anchor 200 within the tissue. The distal anchor 200 may be a metallic material or a polymeric material, and the material of the distal anchor 200 may be a degradable material or a non-degradable material.

Connector 300 and proximal anchor 100 are separated from one another prior to implantation, and connector 300 and proximal anchor 100 can be assembled and secured during implantation into the respective tissues. After the anchoring device is implanted, connector 300 is connected to proximal anchor 100 and the position of connector 300 relative to proximal anchor 100 is fixed. The connector 300 may be made of a metal material or a polymer material, and the metal material or the polymer material may also be degradable or non-degradable.

Referring to fig. 6 to 13, fig. 6 is a schematic view of an anchoring device according to a first embodiment of the present invention implanted in a urethra, and fig. 7 to 13 are first, second, third, fourth, fifth, sixth and seventh schematic views of an anchoring device according to a first embodiment of the present invention implanted in a urethra, wherein the anchoring device mechanically separates the left prostate lobe P1 and the right prostate lobe P2 to push the prostatic hyperplasia tissue pressing the urethra back to the far side for treating benign prostatic hyperplasia as follows, and similar anchoring devices can also be implanted in other anatomical structures for treating other diseases.

First, sheath 810 is advanced through the urethra such that the distal end of sheath 810 is placed adjacent to the region of the urethra that is obstructed by the hypertrophied prostate tissue; and the distal anchoring delivery device 820 is introduced through the sheath 810, and the distal anchoring delivery device 820 is advanced through the sheath 810 such that the distal end of the distal anchoring delivery device 820 exits the distal end of the sheath 810. Wherein the distal anchoring delivery device 820 can be placed into the sheath 810 after the distal end of the sheath 810 is placed near the region where the urethra is obstructed, or the distal anchoring delivery device 820 can be preloaded into the sheath 810 prior to placement of the sheath 810. Reference is made to fig. 7 after the distal end of the distal anchoring delivery device 820 has exited the distal end of the sheath 810.

Next, needle-like delivery tube 830 is introduced through distal anchoring delivery device 820, needle-like delivery tube 830 is advanced through distal anchoring delivery device 820 such that needle-like delivery tube 830 passes through the distal opening of distal anchoring delivery device 820 to the exterior of sheath 810, needle-like delivery tube 830 is further advanced, penetrating the tissue of the prostate and the distal end of needle-like delivery tube 830 exits the prostate capsule, see fig. 8.

Next, distal anchor 200 passes through the distal end of needle-like delivery tube 830, see fig. 9; retracting needle-like delivery tube 830 such that needle-like delivery tube 830 is removed from distal anchor delivery device 820, thereby releasing distal anchor 200, see fig. 10; removing the distal anchor delivery device 820 from the sheath 810 and adjusting the position of the distal anchor 200, see fig. 11; the proximal anchor delivery device 840 is advanced through the sheath 810 such that the distal end of the proximal anchor delivery device 840 exits the distal end of the sheath 810. Before the distal end of the proximal anchor delivery device 840 exits the distal end of the sheath 810, the connector 300 may be passed through the proximal anchor 100 located in the proximal anchor delivery device 840, while the connector 300 and the proximal anchor 100 are still in a separated state, and the position of the connector 300 relative to the proximal anchor 100 may be adjusted in real time, see fig. 12.

Again, pulling distal anchor 200 through connector 300 to adjust the relative position between distal anchor 200 and proximal anchor 100, thereby contracting the enlarged prostatic tissue; thereafter, proximal anchors 100 are connected to connector 300 to fix the position of connector 300 relative to proximal anchors 100, and proximal anchors 100 are released from proximal anchor delivery device 840, thereby deploying proximal anchors 100 into tissue and thereby deploying one of the anchors into tissue, see fig. 13.

Subsequently, depending on the patient's actual condition, the above procedure is repeated to implant additional anchoring devices into the urethra, typically 4-6 pairs of anchoring devices, which act together to treat benign prostatic hyperplasia.

Example two

The present embodiment provides an anchoring device, and the anchoring device in the present embodiment is a further improvement of the anchoring device in the first embodiment. Referring to fig. 14 and 15, fig. 14 and 15 are two schematic structural views of the proximal anchor 100 in an anchoring device according to a second embodiment of the present invention, in which the first protrusion 112 includes at least one second groove 113.

Since the first protrusion 112 includes at least one second groove 113. Therefore, the roughness of the contact surface 110 can be further increased, so that the frictional resistance of the proximal anchor 100 to the movement of the tissue can be further increased, the adherence performance of the proximal anchor 100 can be further improved, the risk of displacement of the proximal anchor 100 to the tissue can be reduced, and the anchoring stability of the anchoring device can be further improved; the contact area of the contact surface 110 with the tissue may be further increased, thereby improving the anchoring stability of the anchoring device.

Preferably, referring to fig. 14 and 15, the second groove 113 contains a medicament 400 therein. Thereby increasing the area of the contact surface 110 on which the drug 400 is disposed and further improving the therapeutic effect of the anchoring device.

The second groove 113 may be a U-shaped groove or a V-shaped groove. The second groove 113 may communicate with two adjacent first grooves 111 of the first protrusion 112, may communicate with only one adjacent first groove 111 of the first protrusion 112, or two adjacent first grooves 111 of the first protrusion 112 form two side protrusions. As shown in fig. 14 and 15, the second groove 113 communicates with two first grooves 111 adjacent to the first projection 112.

Referring to fig. 14 and 15, a plurality of continuous second grooves 113 are distributed along the width of the proximal anchor 100. In other embodiments, a plurality of continuous second grooves 113 may also be distributed along the length of proximal anchor 100, or in any direction.

Preferably, the plurality of second grooves 113 are identical in shape and size, and the plurality of continuous second grooves 113 are uniformly distributed along the width direction of the proximal anchor 100, so that the second grooves 113 can be easily machined. The second groove 113 may be formed by passivation processing, knurling, laser processing, electrical discharge machining, or the like.

Preferably, the first protrusion 112 further includes at least one second protrusion 114, and the second protrusion 114 is disposed at both sides of the second groove 113. In this way, the roughness of the contact surface 110 of the proximal anchor 100 may be further enhanced, the adherence performance of the proximal anchor 100 may be improved, the risk of displacement of the proximal anchor 100 with respect to the tissue may be reduced, and the anchoring stability of the anchoring device may be improved.

Further, the second protrusion 114 has at least one tip. Thus, when the tip of each second protrusion 114 pierces the tissue, the drug 400 in the first groove 111 and the second groove 113 can more easily penetrate into the tissue, the drug loading capacity in the first groove 111 and the second groove 113 can be correspondingly reduced, the effectiveness of the drug 400 can be improved, and the utilization rate of the drug 400 can be improved to the greatest extent while the cost is reduced. Meanwhile, the roughness of the contact surface 110 of the proximal anchor 100 can be further enhanced, the adherence performance of the proximal anchor 100 can be improved, the risk of the proximal anchor 100 shifting relative to the tissue can be reduced, and the anchoring stability of the anchoring device can be improved.

In this embodiment, the second groove 113 may further have a drug 400, and further the drug 400 may further have a protective layer 500, and the specific arrangement manner is the same as that of the drug 400 and the protective layer 500 in the first embodiment, and is not described herein again.

EXAMPLE III

The present embodiment provides an anchoring device. The difference between the anchoring device of the first embodiment and the anchoring device of the second embodiment is that, referring to fig. 16, fig. 16 is a schematic structural view of the proximal anchoring device 100 of the third embodiment of the present invention, and in this embodiment, the recess comprises a plurality of third grooves 115 disposed on the contact surface 110.

As shown in fig. 16, the plurality of third grooves 115 are distributed in a dot shape. The shape of the third groove 115 in a cross section perpendicular to the contact surface 110 may be V-shaped, U-shaped, or rectangular. The third groove 115 is circular in shape in a cross section parallel to the contact surface 110. In other embodiments, the shape of the third groove 115 in a cross section parallel to the contact surface 110 may be elliptical. Preferably, the plurality of third grooves 115 are uniformly distributed, which may facilitate the processing.

The medicine 400 may be received in the third groove 115. After the anchoring device is fixed in the tissue, the tissue can be treated through the medicine 400, the medicine 400 arranged in the concave part can realize targeted release, the long-term washing of the urethra to the medicine 400 can be avoided to influence the curative effect, the treatment effect of the anchoring device is further improved, and the medicine carrying amount can be reduced while the same treatment effect is achieved.

The drug 400 and the protection layer 500 in this embodiment can also be disposed in the third groove 115 in the same manner as the drug 400 and the protection layer 500 in the first embodiment, and are not described herein again.

The contact surface 110 further comprises a plurality of third protrusions (not shown) arranged around the third recess 115. Thus, the third protrusion may further increase the roughness of the contact surface 110, improve the adherence performance of the proximal anchor 100, reduce the risk of displacement of the proximal anchor 100 relative to the tissue, and improve the anchoring stability of the anchoring device. Specifically, the third protrusion extends from an edge of the third groove 115.

Further, the third protrusion has at least one tip.

Example four

The present embodiment provides an anchoring device. The difference between the anchoring device in the present embodiment and the anchoring device in the first embodiment is that, referring to fig. 17, fig. 17 is a schematic structural view of the proximal anchoring device 100 in the fourth embodiment of the present invention, and in the present embodiment, the recess portion penetrates through the proximal anchoring device 100.

Specifically, as shown in fig. 17, the recess is a through hole 117, and the through hole 117 extends through the proximal anchor 100. The plurality of through holes 117 are distributed in a dot shape. The through-hole 117 is circular in shape in a cross section parallel to the contact face 110. In other embodiments, the shape of the through-hole 117 in a cross-section parallel to the contact face 110 is elliptical. Preferably, the plurality of through holes 117 are uniformly distributed, which may facilitate processing.

The medicine 400 may be accommodated in the through-hole 117 (refer to the recess in fig. 17). After the anchoring device is fixed in the tissue, the tissue can be treated through the medicine 400, the medicine 400 arranged in the concave part can realize targeted release, the long-term washing of the urethra to the medicine 400 can be avoided to influence the curative effect, the treatment effect of the anchoring device is further improved, and the medicine carrying amount can be reduced while the same treatment effect is achieved.

In this embodiment, the anchoring device further comprises a protective layer 500, the protective layer 500 being disposed in the through hole 117 and covering both outer surfaces of the inner wall of the drug 400 away from the through hole 117. Because the protective layer 500 is disposed in the through hole 117 and covers the outer surface of the inner wall of the drug 400 far from the through hole 117, the loss speed of the drug 400 can be reduced, the release condition of the drug 400 can be improved, and the treatment effect can be improved, especially when flowing substances exist around the anchoring device, the situation that the flowing substances directly wash the drug 400, the drug 400 is lost, and the treatment effect is affected can be avoided.

Preferably, the contact surface 110 further comprises a plurality of fourth protrusions, the fourth protrusions being disposed around the through hole 117. Specifically, the fourth protrusion extends from the edge of the through hole 117.

Further, the fourth protrusion has at least one tip.

EXAMPLE five

The present embodiment provides an anchoring device. The difference between the anchoring device of the first embodiment and the anchoring device of the second embodiment is that, referring to fig. 18, fig. 18 is a schematic structural view of the proximal anchoring device 100 of the fifth embodiment of the present invention, and in this embodiment, the recess includes a plurality of fourth grooves 118 disposed on the contact surface 110.

As shown in fig. 18, a plurality of fourth grooves 118 are distributed along the length of proximal anchor 100. The fourth groove 118 has a V-shape, a U-shape, or a rectangular shape in a cross section perpendicular to the contact surface 110. The shape of the fourth groove 118 in a cross-section parallel to the contact surface 110 is wave-shaped. In other embodiments, the fourth groove 118 may be saw-toothed in shape in a cross-section parallel to the contact surface 110.

Preferably, the plurality of fourth grooves 118 are uniformly distributed, which can facilitate the processing.

Referring to fig. 18, a medicament 400 may be received in the fourth recess 118. After the anchoring device is fixed in the tissue, the tissue can be treated through the medicine 400, the medicine 400 arranged in the concave part can realize targeted release, the long-term washing of the urethra to the medicine 400 can be avoided to influence the curative effect, the treatment effect of the anchoring device is further improved, and the medicine carrying amount can be reduced while the same treatment effect is achieved.

The drug 400 and the protection layer 500 in this embodiment can also be disposed in the fourth groove 118, and the specific disposing manner is the same as that of the drug 400 and the protection layer 500 in the first embodiment, and will not be described herein again. In other embodiments, the bottom of the fourth groove 118 may extend through the proximal anchor 100 to form a wave-shaped through-hole 117 in the proximal anchor 100.

Preferably, the contact surface 110 further includes a plurality of fifth protrusions, the fifth protrusions being disposed around the fourth recess 118. Specifically, the fifth protrusion extends from an edge of the fourth groove 118.

Further, the fifth projection has at least one tip.

EXAMPLE six

The present embodiment provides an anchoring device. Referring to fig. 19 and 20, fig. 19 is a schematic structural view of an anchoring device in a sixth embodiment of the present invention, and fig. 20 is a schematic structural view of a proximal anchor 100 in an anchoring device in a sixth embodiment of the present invention, the anchoring device including the proximal anchor 100, a distal anchor 200 and a connecting member 300.

Referring to fig. 19 and 20, proximal anchor 100 includes a first clip portion 120, a second clip portion 130, a first tab portion 140, and a second tab portion 150. The first clamping portion 120 has a first fixed end and a first free end, the second clamping portion 130 has a second fixed end and a second free end, the first elastic piece portion 140 has a third fixed end and a third free end, and the second elastic piece portion 150 has a fourth fixed end and a fourth free end. The first fixed end of the first clamping portion 120 is fixedly connected to the third fixed end of the first elastic sheet portion 140, and the second fixed end of the second clamping portion 130 is fixedly connected to the fourth fixed end of the second elastic sheet portion 150. The first fixing end of the first clamping portion 120 and the second fixing end of the second clamping portion 130 are connected. The proximal end of the connector 300 is selectively connected to the first clip portion 120 and the second clip portion 130. The distal end of connector 300 is fixedly attached to distal anchor 200. When the proximal end of the connector 300 is connected to the first and second clamping portions 120 and 130, the first and second clamping portions 120 and 130 clamp the connector 300.

Fig. 21 is a force analysis diagram of the proximal anchor 100 in the anchoring device according to the sixth embodiment of the present invention, and as shown in fig. 21, when the proximal end of the connecting member 300 is connected to the first holding portion 120 and the second holding portion 130, the first holding portion 120 and the second holding portion 130 hold one end of the connecting member 300, so that the first holding portion 120 and the second holding portion 130 can apply a holding force F1 to the connecting member 300 to hold the connecting member 300, and the corresponding connecting member 300 can apply a reaction force F2 opposite to the holding force F1 to the proximal anchor 100. The free ends of the first clamping portion 120 and the second clamping portion 130 open under the action of the reaction force F2. Since the first elastic sheet portion 140 extends from one end of the first clamping portion 120, the second elastic sheet portion 150 extends from one end of the second clamping portion 130, one ends of the first clamping portion 120 and the second clamping portion 130 are fixedly connected, and both the first elastic sheet portion 140 and the second elastic sheet portion 150 have free ends, under the action of the reaction force F2, the first elastic sheet portion 140 and the second elastic sheet portion 150 are close to each other and deform, particularly, the free ends of the first elastic sheet portion 140 and the free ends of the second elastic sheet portion 150, and the corresponding first elastic sheet portion 140 and the corresponding second elastic sheet portion 150 generate the restoring force F3 to restore the deformation, so that the restoring force F3 can reduce the degree of the opening of the free ends of the first clamping portion 120 and the second clamping portion 130, thereby enabling the connection between the first clamping portion 120 and the second clamping portion 130 and the connecting member 300 to be more stable, and improving the stability of the anchoring device.

Referring to fig. 21, the first clamping portion 120 and the second clamping portion 130 are a unitary piece. The first clamping portion 120 and the second clamping portion 130 are integrally connected at a first fixed end of the first clamping portion 120 and a second fixed end of the second clamping portion 130, and a distance between the first clamping portion 120 and the second clamping portion 130 is gradually increased from the first fixed end of the first clamping portion 120 to the first free end. For example, the first clamping portion 120 and the second clamping portion 130 may be formed by laser cutting or the like. When connector 300 is gradually moved from the opening between the free end of first clip 120 and the free end of second clip 130 to the opening between the fixed end of first clip 120 and the fixed end of second clip 130, i.e., connector 300 is moved from the outside of proximal anchor 100 to the inside of proximal anchor 100, the clamping force applied by first clip 120 and second clip 130 to connector 300 is gradually increased, thereby facilitating assembly of connector 300 into first clip 120 and second clip 130.

Referring to fig. 22, fig. 22 is another schematic view of proximal anchor 100 in an anchoring device according to a sixth embodiment of the present invention, wherein first clamping portion 120 and second clamping portion 130 are a single piece. The first clamping portion 120 and the second clamping portion 130 are integrally connected at a first fixed end of the first clamping portion 120 and a second fixed end of the second clamping portion 130, and the first clamping portion 120 and the second clamping portion 130 are equidistant. For example, the first clamping portion 120 and the second clamping portion 130 may be formed by laser cutting or the like.

Referring to fig. 22, a portion of the first clamping portion 120, which is close to one end of the first clamping portion 120 and opposite to the second clamping portion 130, is provided with first saw teeth 121, a portion of the second clamping portion 130, which is close to one end of the second clamping portion 130 and opposite to the first clamping portion 120, is provided with second saw teeth 131, and the first saw teeth 121 and the second saw teeth 131 are symmetrically arranged, so that the connection stability between the first clamping portion 120 and the connecting member 300 and the connection stability between the second clamping portion 130 and the connecting member 300 can be further improved.

Specifically, the first saw teeth 121 correspond to teeth of the second saw teeth 131, and gaps between the teeth of the first saw teeth 121 correspond to gaps between the teeth of the second saw teeth 131.

Preferably, referring to fig. 22, the junction between one end of the first clamping portion 120 and one end of the second clamping portion 130 is in a circular arc transition, so that the stress concentration at the junction can be reduced.

Proximal anchor 100 may be a metallic material or a polymeric material, and the material of proximal anchor 100 may be a degradable material or a non-degradable material.

In this embodiment, as shown in fig. 19, the contact surface 110 of the proximal anchor 100 is located on one side of the first clip portion 120, the second clip portion 130, the first tab portion 140, and the second tab portion 150 near the proximal end of the connector 300.

In this embodiment, the procedure for implanting the anchoring device into the tissue can be referred to in the first embodiment. Wherein, during implantation of the anchoring device in tissue, connector 300 may be placed in the opening between the other end of first clamping portion 120 and second clamping portion 130 as connector 300 is passed through proximal anchor 100 located in proximal anchor delivery device 840; when the proximal anchor 100 is connected and fixed to the connector 300, the connector 300 can be gradually moved from the opening between the other end of the first clamping portion 120 and the other end of the second clamping portion 130 to the opening between the one end of the first clamping portion 120 and the one end of the second clamping portion 130, and even if the connector 300 is moved from the outside of the proximal anchor 100 to the inside of the proximal anchor 100, the clamping force applied to the connector 300 by the first clamping portion 120 and the second clamping portion 130 is gradually increased, so that the first clamping portion 120 and the second clamping portion 130 clamp the connector 300, and the connection and fixation of the first clamping portion 120 and the second clamping portion 130 to the connector 300 is realized.

EXAMPLE seven

The present embodiment provides an anchoring device. Referring to fig. 23, fig. 23 is a schematic view of the proximal anchor 100 in the seventh embodiment of the present invention, which is different from the sixth embodiment in that the first serrations 121 and the second serrations 131 are alternately arranged.

Specifically, referring to fig. 23, a portion of the first clamping portion 120 close to one end of the first clamping portion 120 and opposite to the second clamping portion 130 is provided with first saw teeth 121, a portion of the second clamping portion 130 close to one end of the second clamping portion 130 and opposite to the first clamping portion 120 is provided with second saw teeth 131, teeth of the first saw teeth 121 and teeth of the second saw teeth 131 are alternately arranged, and corresponding gaps between the teeth of the first saw teeth 121 and gaps between the teeth of the second saw teeth 131 are alternately arranged.

Example eight

The present embodiment provides an anchoring device. Referring to fig. 24, fig. 24 is a cross-sectional view of the proximal anchor 100 in the anchoring device according to the eighth embodiment of the present invention, and the anchoring device according to the sixth embodiment of the present invention is different from the anchoring device according to the sixth embodiment in that the first clamping portion 120 and the second clamping portion 130 are separately provided, and the anchoring device further includes a fixing member 600, and the fixing member 600 is fixedly connected to the first fixing end of the first clamping portion 120 and the second fixing end of the second clamping portion 130, respectively. In this way, the restoring force F3 generated by the first spring portion 140 and the second spring portion 150 to restore the deformation can be enhanced, so that the connection stability between the first clamping portion 120 and the second clamping portion 130 and the connection member 300 can be further improved, and the processing of the proximal anchor 100 can be simplified.

As shown in fig. 24, a first fixing end of the first clamping portion 120 and a second fixing end of the second clamping portion 130 are respectively provided with a first mounting through hole 122 and a second mounting through hole 132 which are opposite to each other, and the fixing member 600 passes through the first mounting through hole 122 and the second mounting through hole 132 and is fixedly connected with the first clamping portion 120 and the second clamping portion 130. The first fixing end of the first clamping portion 120 and the second fixing end of the second clamping portion 130 are fixedly connected by a fixing member 600.

In this embodiment, the fixing member 600 is a cylindrical pin, and the fixing member 600 is welded to the first clamping portion 120 and the second clamping portion 130. In other embodiments, the fixing member 600 may also be a pin with other shapes, and the fixing member 600 may also be fixedly connected to the first clamping portion 120 and the second clamping portion 130 by riveting; the fixing member 600 may also be a fastener such as a screw or a bolt.

Example nine

The present embodiment provides an anchoring device, and the anchoring device in the present embodiment is a further modification of the anchoring device in the sixth embodiment. Referring to fig. 25, fig. 25 is a schematic view of the proximal anchor 100 in the anchoring device according to the ninth embodiment of the present invention, in this embodiment, the first elastic sheet portion 140 has a plurality of first reinforcing teeth 141 extending in a direction toward the second elastic sheet portion 150, the second elastic sheet portion 150 has a plurality of second reinforcing teeth 151 extending in a direction toward the first elastic sheet portion 140, the plurality of first reinforcing teeth 141 and the plurality of second reinforcing teeth 151 are disposed opposite to each other, and when the proximal end of the connecting member 300 is connected to the first clamping portion 120 and the second clamping portion 130, the first reinforcing teeth 141 and the second reinforcing teeth 151 contact each other. When the proximal end of the connecting member 300 is connected to the first clamping portion 120 and the second clamping portion 130, the first spring tab portion 140 and the second spring tab portion 150 are deformed by the reaction force F2 approaching each other, and the restoring force F3 generated by the first spring tab portion 140 and the second spring tab portion 150 is stronger due to the mutual contact of the first reinforcing tooth 141 and the second reinforcing tooth 151, so that the connection between the first clamping portion 120 and the connecting member 300 and the second clamping portion 130 is more stable, and the stability of the anchoring device is improved.

Example ten

The present embodiment provides an anchoring device, and the anchoring device in the present embodiment is a further modification of the anchoring device in the sixth embodiment. Referring to fig. 26, fig. 26 is a schematic view of the proximal anchor 100 in the anchoring device according to the tenth embodiment of the present invention, in this embodiment, the anchoring device includes at least one elastic element 700, the elastic element 700 is disposed between the first elastic sheet portion 140 and the second elastic sheet portion 150, and when the proximal end of the connecting member 300 is connected to the first clamping portion 120 and the second clamping portion 130, the elastic element 700 is in a compressed state. When the proximal end of the connecting member 300 is connected to the first clamping portion 120 and the second clamping portion 130, the first spring tab portion 140 and the second spring tab portion 150 are deformed by the reaction force F2 approaching each other, and the elastic element 700 is in a compressed state, so that the restoring force F3 generated by the first spring tab portion 140 and the second spring tab portion 150 is stronger, and the connection between the first clamping portion 120 and the connecting member 300 and the connection between the second clamping portion 130 and the connecting member 300 are more stable, thereby improving the stability of the anchoring device.

As shown in fig. 26, the elastic member 700 is a spring, one end of the elastic member 700 is connected to the first tab portion 140, and the other end of the elastic member 700 is connected to the second tab portion 150. The elastic member 700 may be fixedly connected to the first tab portion 140 and the second tab portion 150 by an adhesive, welding, or the like. The number of the elastic elements 700 may be four, and in other embodiments, the number of the elastic elements 700 may also be two, three, etc., which are not described herein again. The elastic element 700 may also be a spring plate or other elastic element. In other embodiments, the elastic element 700 may be integrally formed with the first and second tab portions 140 and 150.

EXAMPLE eleven

The present embodiment provides an anchoring device. Referring to fig. 27 and 28, fig. 27 is a schematic structural view of an anchoring device according to an eleventh embodiment of the present invention, and fig. 28 is a sectional view of an anchoring device according to an eleventh embodiment of the present invention, which includes a proximal anchor 100, a distal anchor 200, and a connecting member 300. The distal anchor 200 comprises a tubular anchor body 210 and a bending part 220 extending from one end of the anchor body 210 and bent, and the provision of the bending part 220 facilitates fixation of the distal anchor 200 within the tissue, reducing the risk of displacement of the distal anchor 200 within the tissue. The distal anchor 200 may be a metallic material or a polymeric material, and the material of the distal anchor 200 may be a degradable material or a non-degradable material.

The connector 300 includes a first connection portion and a second connection portion extending from one end of the first connection portion, the first connection portion is disposed inside N of the lumen of the anchoring main body 210, the second connection portion is disposed outside W of the lumen of the anchoring main body 210, the second connection portion is selectively connected to the proximal anchor 100, the first connection portion includes a plurality of fixing grooves 310, and the tube wall of the anchoring main body 210 extends toward the inside N of the lumen to form a plurality of limiting recesses 211 matched with the fixing grooves 310.

Because the first connecting portion includes a plurality of fixing grooves 310, and the tube wall of the anchoring main body 210 extends toward the inside N of the tube cavity to form a plurality of limiting concave portions 211 matched with the fixing grooves 310, the connecting member 300 can be prevented from moving axially along the tube cavity of the anchoring main body 210 and rotating relative to the anchoring main body 210, so that the stability of connection between the distal anchoring 200 and the connecting member 300 is improved, and the stability of the anchoring device is further improved.

The plurality of fixing grooves 310 and the limiting recesses 211 matched with the fixing grooves 310 may be formed by pressing, that is, the first connecting portion is connected to the anchoring main body 210 in a pressing manner, the plurality of fixing grooves 310 are formed on the first connecting portion, and the plurality of limiting recesses 211 extending to the inner portion N of the lumen are formed on the tube wall of the anchoring main body 210.

Referring to fig. 27 and 28, the shape of the cross-section of the restraining recess 211 in the direction extending into the lumen of the anchoring body 210 is semicircular, and in other embodiments, the shape of the cross-section of the restraining recess 211 in the direction extending into the lumen of the anchoring body 210 may be U-shaped.

Further, a limiting portion 320 extends from the other end of the first connecting portion, and the limiting portion 320 is used for limiting the first connecting portion from sliding out of the inner portion N of the lumen of the anchoring main body 210. Since the stopper 320 is used to limit the first connecting part from slipping out of the inside N of the lumen of the anchoring body 210, the connecting part 300 can be limited from moving axially along the lumen of the anchoring body 210, so as to further improve the stability of the connection between the distal anchor 200 and the connecting part 300, and thus improve the stability of the anchoring device. In the process of connecting the connector 300 and the distal anchor 200, the other end of the first connecting portion may first penetrate through the lumen of the anchor body 210 and then penetrate out of the lumen of the anchor body 210, and then the distal end of the connector 300 may have a stopper 320. When the connecting member 300 has a rod shape, the distal end of the connecting member 300 may be thicker than the lumen of the anchoring body 210 by pressing or the like, thereby forming a stopper 320. When the connecting member 300 is in the form of a rope, the distal end of the connecting member 300 may be thicker than the lumen of the anchoring body 210 by tying a rope or the like, thereby forming a stopper 320.

As shown in fig. 27, the angle between the bend 220 and the axial direction of the lumen of the anchor body 210 is between 0-90 °, which facilitates fixation of the distal anchor 200 within the tissue and reduces the risk of displacement of the distal anchor 200 within the tissue. The bent portion 220 may be a sheet-like structure extending from an opening at one end of the anchor body 210.

Specifically, the bending portion 220 includes a transition section 221 and a bending section 222, one end of the transition section 221 is connected to one end of the anchoring main body 210, the other end of the transition section 221 is connected to one end of the bending section 222, and the other end of the bending section 222 is a free end. As shown in fig. 27, the angle between the bend 222 and the axial direction of the lumen of the anchoring body 210 is between 0-90 °. The lateral extension of the transition section 221 is smoothly connected with the side of the bending section 222.

Fig. 29 is a schematic view of the anchoring device according to the eleventh embodiment of the present invention, wherein the distal anchor 200 is provided with a drug 400, and referring to fig. 29, the anchoring device further comprises a drug 400, and the drug 400 is disposed in the limiting recess 211. After the anchoring device is fixed in the tissue, the tissue can be treated through the medicine 400, the medicine 400 arranged in the limiting concave part 211 can realize targeted release, the medicine 400 can be prevented from being washed by flowing substances for a long time to influence the curative effect, the treatment effect of the anchoring device is further improved, and the medicine-carrying quantity can be reduced while the same treatment effect is achieved.

The drug 400 may be an anti-cell proliferation drug 400, such as rapamycin, taxol, zotarolimus, everolimus, and the like. When the anchoring device is implanted in the urethra for the treatment of benign prostatic hyperplasia, the drug 400 in the anchoring device may inhibit further hyperplasia of the prostate, thereby reducing the problem of urethral restenosis caused by prostatic hyperplasia after the anchoring device is implanted. The medicine 400 may be directly sprayed or provided in the stopper recess 211 in such a manner that the medicine 400 is recrystallized.

Further, the drug 400 may be disposed on the outer surface of the distal anchor 200 other than the contact surface 110. The drug 400 may also be disposed on the outer surface of the contact surface 110 of the distal anchor 200 other than the retaining recess 211 and on the outer surface of the connector 300.

Further, the anchoring device further comprises a protective layer 500, wherein the protective layer 500 is disposed in the limiting recess 211 and covers the outer surface of the side of the medicament 400 away from the limiting recess 211.

Referring to fig. 27, the connecting member 300 is L-shaped, and the first connecting portion is bent with respect to the second connecting portion. Connector 300 and proximal anchor 100 may be assembled and connected during implantation into the corresponding tissue. After the anchoring device is implanted, the position of connector 300 relative to proximal anchor 100 is fixed.

The connector 300 may be made of a metal material or a polymer material, and the metal material or the polymer material may also be degradable or non-degradable. The connector 300 may be in the form of a rope or a rod. In this embodiment, reference may be made to the first embodiment for a process of implanting an anchoring device into a tissue, which is not described herein again.

Example twelve

The present embodiment provides an anchoring device. Referring to fig. 30, fig. 30 is a schematic view showing the case where the drug 400 is provided on the distal anchor 200 in the twelfth embodiment of the present invention, and the anchoring device in this embodiment is different from the anchoring device in the eleventh embodiment in that the cross section of the limiting recess 211 in the direction extending into the lumen of the anchoring main body 210 has a trapezoidal shape.

EXAMPLE thirteen

The present embodiment provides an anchoring device. Referring to fig. 31, fig. 31 is a schematic view showing the case where the drug 400 is provided on the distal anchor 200 in the thirteenth embodiment of the present invention, and the anchoring device in this embodiment is different from the anchoring device in the eleventh embodiment in that the shape of the cross section of the stopper recess 211 in the direction extending into the lumen of the anchoring main body 210 is V-shaped.

Example fourteen

The present embodiment provides an anchoring device. Referring to fig. 32, fig. 32 is a schematic view of the anchoring device according to the fourteenth embodiment of the present invention, in which the drug 400 is provided on the distal anchor 200, and the anchoring device according to the eleventh embodiment of the present invention is different from the anchoring device according to the eleventh embodiment of the present invention in that the size of the radial cross section of the portion of the connecting member 300 disposed inside N of the lumen of the anchoring main body 210 varies along the axis of the anchoring main body 210, and the inner surface of the lumen of the anchoring main body 210 matches the outer surface of the portion of the connecting member 300 disposed inside N of the lumen of the anchoring main body 210.

By varying the size of the radial cross-section of the portion of the connector 300 disposed inside the lumen N of the anchoring body 210 along the axis of the anchoring body 210 and matching the inner surface of the lumen of the anchoring body 210 with the outer surface of the portion of the connector 300 disposed inside the lumen N of the anchoring body 210, the connector 300 is restricted from moving along the axis of the lumen of the anchoring body 210 within the lumen of the anchoring body 210, the risk of the distal end of the connector 300 entering the inside N of the lumen of the anchoring body 210 is reduced, and the stability of the connection of the distal anchor 200 and the connector 300 is improved.

Example fifteen

The present embodiment provides an anchoring device, and the anchoring device in the present embodiment is a further improvement of the anchoring device in the eleventh embodiment. Referring to fig. 33, fig. 33 is a schematic view of a distal anchor 200 according to a fifteenth embodiment of the present invention, comparing with fig. 27, in fig. 27, a side of a bending section 222 is connected to a side of a transition section 221, and the connection is in a smooth transition connection, that is, no notch is formed at the connection between the side of the bending section 222 and the side of the transition section 221, whereas in this embodiment, at least one notch is formed at the connection between the side of the bending section 222 and the side of the transition section 221, so that the stiffness of the bending section 222 is smaller than that of the transition section 221, in fig. 33, the notch is formed by inclined surfaces at both sides of the distal end of the transition section 221, but as will be known to those skilled in the art, the notch may also be formed by an arc surface, a step surface, or other curved and/or straight surface. Because the notch is formed at the joint of the bending section 222 and the transition section 221, the rigidity of the bending section 222 is less than that of the transition section 221, and the connection strength between the bending section 222 and the transition section 221 is weakened, after the distal anchor 200 is implanted into a tissue, when the bending end 222 moves along with the tissue, the transition section 221 is not easy to move along with the movement of the bending end 222, so that the risk of displacement of the whole distal anchor can be reduced, and when the transition section 221 moves, the bending end 222 is not easy to move along with the movement of the transition section 221, so that the risk of displacement of the bending end 222 inside the tissue can be reduced.

Specifically, as shown in fig. 33, the notch 223 formed at the connection between the side of the bending section 222 and the side of the transition section 221 includes a first notch and a second notch. The first notch and the second notch are respectively disposed on two sides of the transition section 221.

When the distal end is anchored, before the bending section 222 of the bending portion is bent relative to the transition section 221, two notches may be formed on two sides of the connection portion between the bending section 222 and the transition section 221. After the bending section 222 of the bending portion is bent and shaped relative to the transition section 221, the two notches are the first notch and the second notch, respectively.

The above description is only for the preferred embodiment of the present invention and is not intended to limit the scope of the present invention, and any modification and modification made by those skilled in the art according to the above disclosure are all within the scope of the claims.

Claims (11)

1. An anchor for selective connection with a connecting member, comprising a first clip portion, a second clip portion, a first tab portion and a second tab portion, the first clamping part is provided with a first fixed end and a first free end, the second clamping part is provided with a second fixed end and a second free end, the first spring plate part is provided with a third fixed end and a third free end, the second spring plate part is provided with a fourth fixed end and a fourth free end, the first fixed end of the first clamping part is fixedly connected with the third fixed end of the first elastic sheet part, the second fixed end of the second clamping part is fixedly connected with the fourth fixed end of the second elastic sheet part, a first fixed end of the first clamping part is connected with a second fixed end of the second clamping part, and the connecting piece is selectively connected with the first clamping part and the second clamping part;

when the connecting piece is connected with the first clamping part and the second clamping part, the first clamping part and the second clamping part clamp the connecting piece.

2. The anchor of claim 1, wherein the first clip portion and the first spring portion are integrally formed, and/or the second clip portion and the second spring portion are integrally formed, and/or the first clip portion and the second clip portion are integrally formed.

3. The anchor of claim 1, further comprising a securing member, the first securing end of the first clip portion and the second securing end of the second clip portion each being fixedly coupled to the securing member.

4. The anchor of any one of claims 1 to 3, wherein the first leaf portion has a plurality of first reinforcing teeth extending in a direction toward the second leaf portion, the second leaf portion has a plurality of second reinforcing teeth extending in a direction toward the first leaf portion, the plurality of first reinforcing teeth and the plurality of second reinforcing teeth are oppositely disposed, and the first reinforcing teeth and the second reinforcing teeth contact each other when the connector is connected to the first clip portion and the second clip portion.

5. The anchor of any one of claims 1 to 3, further comprising a resilient element disposed between the first and second spring portions, the resilient element being in compression when the connector is connected with the first and second clip portions.

6. The anchor of any one of claims 1 to 3, wherein the spacing between the first and second clip portions becomes progressively larger from the first fixed end to the first free end.

7. The anchor of any one of claims 1 to 3, wherein first serrations are provided on a portion of the first clip portion adjacent the first fixed end of the first clip portion and opposite the second clip portion, and second serrations are provided on a portion of the second clip portion adjacent the second fixed end of the second clip portion and opposite the first clip portion.

8. The anchor of claim 7, wherein the first serrations and the second serrations are symmetrically or staggered.

9. An anchoring device comprising a distal anchor, a connector selectively connectable to the anchor, the connector being fixedly connectable to the distal anchor, and the anchor of any one of claims 1 to 8.

10. An anchoring device as defined in claim 9, wherein said distal anchor comprises an anchor body having a tubular shape and a bent portion extending and bent from one end of said anchor body, said connector comprises a first connecting portion and a second connecting portion extending from one end of said first connecting portion,

the first connecting portion is arranged in a tube cavity of the anchoring main body, the second connecting portion is selectively connected with the anchoring piece, the first connecting portion comprises a plurality of fixing grooves, and a plurality of limiting concave portions matched with the fixing grooves extend into the tube cavity from the tube wall of the anchoring main body.

11. An anchoring device according to claim 10, wherein a drug is disposed at one or more of the retaining recess, the outer surface of the distal anchor other than the retaining recess, the outer surface of the anchor, and the outer surface of the connector.

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