CN109806235A - A kind of Fluconazole piece and preparation method thereof - Google Patents
A kind of Fluconazole piece and preparation method thereof Download PDFInfo
- Publication number
- CN109806235A CN109806235A CN201910173969.1A CN201910173969A CN109806235A CN 109806235 A CN109806235 A CN 109806235A CN 201910173969 A CN201910173969 A CN 201910173969A CN 109806235 A CN109806235 A CN 109806235A
- Authority
- CN
- China
- Prior art keywords
- parts
- fluconazole
- preparation
- piece
- packaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 229960004884 fluconazole Drugs 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 9
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 7
- 239000000543 intermediate Substances 0.000 claims abstract description 7
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- 239000004615 ingredient Substances 0.000 claims description 6
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 229920003081 Povidone K 30 Polymers 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 206010017533 Fungal infection Diseases 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 101150056637 Hrh2 gene Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- -1 friability poor Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Fluconazole pieces, including 40-50 parts of Fluconazole；30-40 parts of microcrystalline cellulose；5 parts of calcium phosphate dibasic anhydrous；10-15 parts of PVP K30；Crosslinking completes 8-10 parts of sodium carboxymethylcellulose pyce；1-3 parts of magnesium stearate；It further include preparation method, first by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；Intermediates content is measured, slice weight is calculated；Tabletting, plastic-aluminum, packaging are directly carried out with tablet press machine.This preparation method reduces operational sequence, improves production efficiency, has saved material, reduces energy consumption, reduces environmental pollution.
Description
Technical field
The invention belongs to drugs to manufacture new technical field, and in particular to a kind of Fluconazole piece and preparation method thereof.
Background technique
Fluconazole is Novel triazole antifungal drug, is developed by Pfizer, 1988 first in Denmark, France, love
Your blue and Britain lists, and nineteen ninety is ratified to list in the U.S. through FDA.This product is a kind of drug for treating fungal infection, is wide spectrum
Antifungal has therapeutic effect to the fungal infection of humans and animals, there is tablet, capsule, powder-injection and injection currently on the market
Several dosage forms of liquid.The mechanism of action of this product is mainly the activity of the cytochrome P-450 of high selectivity interference fungi, to press down
The biosynthesis of ergosterol on fungal cell membrane processed.This product oral absorption is good, not by food, antacids, H2 receptor blocking
The influence of medicine is widely used in hospital's antifungal therapy.
Chinese patent application notification number CN103751132A discloses a kind of fluconazole dispersing tablet and preparation method thereof, the Shen
Fluconazole piece please have excellent mouthfeel, it is easy to use, not only can swallowed whole, but also can be placed in water dispersion after take, especially
There is the patient of dysphagia suitable for old man, children etc..But the Fluconazole piece of the application in tableting processes due to by work
The limitation of the conditions such as skill, technology, equipment keeps the compressibility of dispersible tablet, friability poor, and tablet is also fragile during the packaging process
It splits, and complex procedures, energy consumption is higher, causes cost high.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of Fluconazole pieces and preparation method thereof, to solve the prior art
Present in defect.
The technical scheme to solve the above technical problems is that
A kind of Fluconazole piece, in parts by weight, including following ingredient:
A kind of preparation method of Fluconazole piece, includes the following steps:
1) by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；
2) intermediates content is measured, slice weight is calculated；
3) tabletting, plastic-aluminum, packaging are directly carried out with tablet press machine.
The beneficial effects of the present invention are: this preparation method reduces operational sequence, production efficiency is improved, has saved object
Material, reduces energy consumption, reduces environmental pollution.
Specific embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
A kind of Fluconazole piece, in parts by weight, including following ingredient:
A kind of preparation method of Fluconazole piece, includes the following steps:
1) by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；
2) intermediates content is measured, slice weight is calculated；
3) tabletting, plastic-aluminum, packaging are directly carried out with tablet press machine.
Specific embodiment 1:
In parts by weight, following ingredient is weighed:
Then by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；Intermediates content is measured, slice weight is calculated；With
Tablet press machine directly carries out tabletting, plastic-aluminum, packaging.
Specific embodiment 2:
In parts by weight, following ingredient is weighed:
Then by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；Intermediates content is measured, slice weight is calculated；With
Tablet press machine directly carries out tabletting, plastic-aluminum, packaging.
Specific embodiment 3:
In parts by weight, following ingredient is weighed:
Then by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；Intermediates content is measured, slice weight is calculated；With
Tablet press machine directly carries out tabletting, plastic-aluminum, packaging.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (2)
1. a kind of Fluconazole piece, which is characterized in that including following ingredient:
2. a kind of preparation method of Fluconazole piece, which comprises the steps of:
1) by above-mentioned material by uniformly mixed in recipe quantity investment total mix machine；
2) intermediates content is measured, slice weight is calculated；
3) tabletting, plastic-aluminum, packaging are directly carried out with tablet press machine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910173969.1A CN109806235A (en) | 2019-03-13 | 2019-03-13 | A kind of Fluconazole piece and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910173969.1A CN109806235A (en) | 2019-03-13 | 2019-03-13 | A kind of Fluconazole piece and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109806235A true CN109806235A (en) | 2019-05-28 |
Family
ID=66608411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910173969.1A Pending CN109806235A (en) | 2019-03-13 | 2019-03-13 | A kind of Fluconazole piece and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109806235A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116251067A (en) * | 2023-04-23 | 2023-06-13 | 淄博市中心医院 | Fluconazole tablet, preparation method and application |
| CN116251067B (en) * | 2023-04-23 | 2024-06-07 | 淄博市中心医院 | Fluconazole tablet, preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711750A (en) * | 2009-12-29 | 2010-05-26 | 南昌弘益科技有限公司 | Fluconazole dispersing tablet and preparation method thereof |
| WO2011101862A1 (en) * | 2010-02-17 | 2011-08-25 | Fdc Limited | Stabilized fluconazole polymorph iii formulation |
| CN108578377A (en) * | 2018-06-25 | 2018-09-28 | 遂成药业股份有限公司 | A kind of Fluconazole piece and preparation method thereof |
-
2019
- 2019-03-13 CN CN201910173969.1A patent/CN109806235A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711750A (en) * | 2009-12-29 | 2010-05-26 | 南昌弘益科技有限公司 | Fluconazole dispersing tablet and preparation method thereof |
| WO2011101862A1 (en) * | 2010-02-17 | 2011-08-25 | Fdc Limited | Stabilized fluconazole polymorph iii formulation |
| CN108578377A (en) * | 2018-06-25 | 2018-09-28 | 遂成药业股份有限公司 | A kind of Fluconazole piece and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116251067A (en) * | 2023-04-23 | 2023-06-13 | 淄博市中心医院 | Fluconazole tablet, preparation method and application |
| CN116251067B (en) * | 2023-04-23 | 2024-06-07 | 淄博市中心医院 | Fluconazole tablet, preparation method and application |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 1118, langgong Road, Jinshan Industrial Zone, Jinshan District, Shanghai, 201506 Applicant after: Shanghai Huanhua Pharmaceutical Co.,Ltd. Address before: 1118, langgong Road, Jinshan Industrial Zone, Jinshan District, Shanghai, 201506 Applicant before: YOUCARE PHARMACEUTICAL GROUP SHANGHAI PHARMACEUTICAL Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190528 |
|
| RJ01 | Rejection of invention patent application after publication |