CN109805939B - Blood sugar detection device - Google Patents
Blood sugar detection device Download PDFInfo
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- CN109805939B CN109805939B CN201711159824.3A CN201711159824A CN109805939B CN 109805939 B CN109805939 B CN 109805939B CN 201711159824 A CN201711159824 A CN 201711159824A CN 109805939 B CN109805939 B CN 109805939B
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Abstract
A blood sugar detection device comprises a carrier, a flow guide actuator, a microneedle patch, a sensor and a control chip, and is characterized in that the carrier is provided with an inflow channel, a liquid storage channel, a pressure chamber and a liquid storage chamber, the pressure chamber is connected with the inflow channel and the liquid storage channel, and the liquid storage channel is communicated with the liquid storage chamber; a flow-directing actuator enclosing the pressure chamber; a microneedle patch communicating with the inflow channel and having a plurality of hollow microneedles; the sensor is arranged in the liquid storage chamber; the control chip is arranged on the carrier. The hollow microneedles are inserted into the skin of a human body in a minimally invasive mode, the control chip controls the diversion actuator to actuate, so that the hollow microneedles suck interstitial fluid and then convey the interstitial fluid to the fluid storage chamber, the sensor monitors a blood sugar content monitoring value of the interstitial fluid, and finally the monitoring value is transmitted to the control chip, so that the control chip calculates monitoring information.
Description
Technical Field
The present disclosure relates to blood glucose monitoring devices, and more particularly, to a blood glucose monitoring device for monitoring blood glucose of a human body.
Background
The self-detection of blood sugar is an important position for diabetic patients to manage blood sugar, but the current blood sugar machines for measuring blood sugar are not convenient to carry, so that the blood sugar content of the patients is difficult to detect when going out, and in the process of measuring blood sugar, the patients sometimes have the condition of pricking but not bleeding or too little blood volume, so that the patients need to prick again or squeeze blood out with force, so that the psychological fear of the patients is possibly caused, and the improvement is really needed.
Aiming at the defects, the intelligent blood sugar detection device which is safe, convenient to carry and free of pain is developed, the purpose that the blood sugar content of a patient can be measured easily at any time in daily life is achieved, and the problem of traditional blood sugar measurement is solved.
Disclosure of Invention
In order to solve the problem that the traditional blood sugar measuring method causes pain to patients and is inconvenient to carry,
the present disclosure provides a blood glucose detecting device, including: the carrier is provided with a liquid guide channel, a pressure chamber and a liquid storage chamber, the liquid guide channel comprises an inflow channel and a liquid storage channel which are arranged on the carrier in a mutually separated mode, the pressure chamber is communicated with the inflow channel and the liquid storage channel, and the liquid storage channel is communicated with the liquid storage chamber; a flow guiding actuator which is arranged on the carrier and seals the pressure chamber, a micro-needle patch which is attached on the carrier and communicated with the inflow channel and is provided with a plurality of hollow micro-needles for minimally invasive insertion into human skin to draw tissue fluid; a sensor, which is packaged on the carrier and is arranged in the liquid storage chamber to monitor a monitoring value of the blood sugar content in the tissue fluid; the control chip is packaged on the carrier in a system mode to control the actuation of the diversion actuator and receive the monitoring value of the sensor; therefore, the microneedle patch is minimally invasive inserted into human skin by the hollow microneedles, the control chip controls the diversion actuator to actuate, a pressure difference is formed in the pressure chamber, the hollow microneedles are enabled to suck the interstitial fluid and are drawn to the inflow channel to be conveyed to the liquid storage chamber, the sensor monitors the monitoring value of the blood glucose content of the interstitial fluid, and finally the monitoring value is transmitted to the control chip, so that the control chip calculates monitoring information and provides user knowledge.
Drawings
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below, wherein:
fig. 1 is a schematic structural diagram of the blood glucose detecting device of the present disclosure.
Fig. 2 is a schematic view of the blood glucose detecting device according to the present disclosure.
Fig. 3 is a schematic view of a valve plate structure of the blood glucose detecting device.
Fig. 4A and 4B are schematic operation flow diagrams of the blood glucose detecting device shown in fig. 1.
FIG. 5 is a block diagram illustrating electrical connection between related components of the blood glucose detecting device.
[ notation ] to show
3: carrier
31: drainage channel
311: inflow channel
312: liquid storage channel
32: pressure chamber
33a, 33 b: convex part structure
4: liquid storage chamber
5: flow-guiding actuator
51: actuating assembly
52: bearing part
6: valve plate
61: valve bore
62: center part
63: connecting part
7: microneedle patch
71: hollow microneedle
8: sensor with a sensor element
9: control chip
10: transmission module
100: blood sugar detection device
200: external device
Detailed Description
Exemplary embodiments that embody features and advantages of this disclosure are described in detail below in the detailed description.
It is to be understood that the disclosure is capable of various modifications without departing from the scope thereof, and that the description and drawings are to be regarded as illustrative in nature and not as restrictive.
Referring to fig. 1, a blood glucose detecting device 100 includes a carrier 3, a liquid storage chamber 4, a flow guiding actuator 5, a microneedle patch 7, a sensor 8, and a control chip 9. The carrier 3 has a fluid guiding channel 31 and a pressure chamber 32, the fluid guiding channel 31 further includes an inflow channel 311 and a liquid storage channel 312, which are separately disposed on the carrier 3 and are communicated with the inflow channel 311 and the liquid storage channel 312 through the pressure chamber 32, and the liquid storage channel 312 is communicated with the liquid storage chamber 4, the liquid storage chamber 4 can be formed by recessing the carrier 3 or embedded in the carrier 3 for storing liquid; the flow guide actuator 5 is configured on the carrier 3 and covers the pressure chamber 32, and when the flow guide actuator 5 is actuated, an absorbing force is generated to extract liquid; the micro-needle patch 7 is attached to the carrier 3, is communicated with the inflow channel 311, and is provided with a plurality of hollow micro-needles 71, and the plurality of hollow micro-needles 71 are inserted into the skin of the human body through non-invasive or minimally-invasive insertion; furthermore, the sensor 8 and the control chip 9 are integrated on the carrier 3 by Micro Electro Mechanical Systems (MEMS), the sensor 8 is packaged on the carrier 3 through a system and is located inside the liquid storage chamber 4, and the control chip 9 is also packaged on the carrier 3 by the system and is used for controlling the flow guide actuator 5 and receiving and analyzing data monitored by the sensor 8.
Referring to fig. 1 and 2, in the present embodiment, after the hollow microneedles 71 of the microneedle patch 7 are inserted into the human body, and the control chip 9 drives the diversion brake 5 to vibrate vertically, the diversion actuator 5 can expand and compress the volume of the pressure chamber 32 to change the internal pressure to generate the suction force, so that the inflow channel 311 generates the suction force, the hollow microneedles 71 suck the interstitial fluid of the human body, and the interstitial fluid flows through the pressure chamber 32 and the fluid storage channel 312 to enter the fluid storage chamber 4, at this time, the sensor 8 can detect the components in the interstitial fluid, analyze the blood glucose content value therein, and finally transmit the blood glucose monitoring value to the control chip 9 to generate the monitoring information to provide the user with the information. Wherein the tissue fluid is subcutaneous tissue fluid of human body.
The hollow microneedles 71 of the microneedle patch 7 are micro-sized pinholes capable of piercing the skin, and the material thereof may be, but is not limited to, high molecular polymer, metal or silicon, preferably silicon dioxide with high biocompatibility, the pore size of the hollow microneedles 71 is such that the tissue fluid under the skin of the human body can pass through, preferably, the inner diameter of the hollow microneedles 71 is between 10 micrometers (μm) and 550 micrometers (μm), the length of the hollow microneedles 71 is between 400 micrometers (μm) and 900 micrometers (μm), and the hollow microneedles 71 can be inserted into the subcutaneous tissue of the human body to a depth not touching the nerve of the human body, so that no pain is caused at all. The hollow microneedles 71 are arranged on the microneedle patch 7 in an array manner, the distance between every two adjacent hollow microneedles 71 needs to be larger than 200 micrometers, and the interference of mutual influence on flow guiding is avoided, so that the hollow microneedles 71 arranged in the array manner do not have the function that one hollow microneedle 51 is blocked to influence the fluid injection, and other hollow microneedles 71 can continue to have the function of fluid injection in a time-keeping manner.
Referring to fig. 1 and fig. 3, in the blood glucose detecting device 100, a valve plate 6 is disposed in each of the inlet channel 311 and the liquid storage channel 312, a plurality of valve holes 61 are formed in the valve plate 6, and the carrier 3 is provided with a protrusion structure 33a, 33b in each of the inlet channel 311 and the liquid storage channel 312, wherein the protrusion directions of the protrusion structure 33a disposed in the inlet channel 311 and the protrusion structure 33b disposed in the liquid storage channel 312 are opposite, in this embodiment, the protrusion structure 33a disposed in the inlet channel 311 protrudes upward, the protrusion structure 33b disposed in the liquid storage channel 312 protrudes downward, the valve plate 6 is provided with a plurality of valve holes 61 in a partial region corresponding to the pressure chamber 32, and a central portion 62 is connected by a plurality of connecting portions 63, and the plurality of valve holes 61 are disposed between the plurality of connecting portions 63, such that the connecting portions 63 provide elastic support for the central portion 62, and thus, the two protrusion structures 33a, b, c, 33b abut against the valve plate 6 and close their respective valve openings 61 and produce a preload abutment. With the above arrangement, when the flow guide actuator 5 is not operated, the central portion 62 of the valve sheet 6 on the inflow channel 311 and the liquid storage channel 312 can respectively seal and isolate the inflow channel 311 and the liquid storage channel 312, so that tissue fluid can be prevented from flowing backwards in the inflow channel 311 and the liquid storage channel 312.
The flow-guiding actuator 5 further includes an actuating element 51 and a carrier 52, wherein the carrier 52 covers the sealed pressure chamber 32, and the actuating element 51 is attached to the surface thereof, and the actuating element 51 is deformed to drive the carrier 51 to vibrate up and down, so as to change the volume of the pressure chamber 32, so that the pressure inside the pressure chamber 32 is changed to generate a pumping force to deliver the tissue fluid.
In the present embodiment, the actuating element 51 may be a piezoelectric element, but not limited thereto.
Referring to fig. 4A and 4B, after the guiding actuator 5 receives the driving signal sent by the control chip 9, the actuating element 51 of the guiding actuator 5 begins to deform due to the piezoelectric effect, and links the bearing member 52 tightly attached thereto to perform vertical bending vibration. Referring to fig. 4A, when the carrier 52 is moved upward by the actuating assembly 51, the volume of the pressure chamber 32 increases to generate a negative pressure to drive the valve plate 6 of the inflow channel 311 to move upward, so that the central portion 62 (as shown in fig. 3) is separated from the protrusion 33a, and at this time, the inflow channel 311 is communicated with the pressure chamber 32, and the pressure chamber 32 is under the negative pressure to draw the interstitial fluid in the microneedle patch 7 under the inflow channel 311, so that the interstitial fluid passes through the inflow channel 311 and passes through the valve hole 61 (as shown in fig. 3)
Into the pressure chamber 32; referring to fig. 4B, the driving chip 9 continuously outputs a driving signal to the fluid guiding actuator 5, the actuating element 51 drives the carrier 52 to move downward, the volume of the pressure chamber 32 is compressed, a pushing force is generated to push the valve plate 6 in the fluid storage channel 312 to move downward, the central portion 62 (shown in fig. 3) is separated from the protrusion portion 33B, tissue fluid in the pressure chamber 32 is pushed into the fluid storage channel 312 through the valve hole 61 (shown in fig. 3), and finally enters the fluid storage chamber 4.
Please refer to fig. 1 and 5, which are block diagrams illustrating the component link relationship of the blood glucose detecting device of the present disclosure, in the present embodiment, the blood sugar detecting device may further include a transmission module 10, the control chip 9 is configured on the carrier 3, and is electrically connected with the diversion actuator 5, the sensor 8 and the transmission module 10, the sensor 8 monitors the blood sugar content in the tissue fluid of the subcutaneous tissue of the human body, to generate a corresponding monitoring value, and transmit the monitoring value to the control chip 9, after the control chip 9 receives the monitoring value of the sensor 8, the control chip 9 analyzes the monitoring value to generate a monitoring message, and then transmits the monitoring message to the transmission module 10, and the transmission module 10 transmits the monitoring message of blood sugar content to an external device 200, the external device 200 may be one of a cloud system, a portable device, a computer system, a display device, an insulin injection device, and the like.
The control chip 9 may further include a graphene battery (not shown) for providing power.
In addition, the transmission module 10 can transmit the data to the external device 200 through wired transmission or wireless transmission,
the wired transmission method is as follows, for example: one of the wired transmission modules of USB, mini-USB, micro-USB, etc. or the wireless transmission mode is as follows, for example: a Wi-Fi module, a Bluetooth module, a radio frequency identification module, a near field communication module, and the like.
In summary, the present invention provides a blood glucose detecting device, wherein after a microneedle patch is inserted into a subcutaneous tissue of a human body, a pressure gradient is generated by the actuation of a guiding actuator, so that a plurality of hollow microneedles in the microneedle patch generate a suction force to suck a tissue fluid of the subcutaneous tissue, the tissue fluid enters a fluid storage chamber through the guiding actuator, a sensor located in the fluid storage chamber detects a monitoring value of blood glucose content in the tissue fluid, a control chip analyzes the monitoring value to generate monitoring information, the monitoring information is transmitted to a transmission module through the control chip to be known to a user, and the graphene battery is arranged, so that the blood glucose detecting device can easily, simply and anytime and anywhere measure blood glucose without power plug-in, and reduce the blood glucose measurement of the user, and in addition, the blood glucose detecting device uses the tissue fluid of the subcutaneous tissue obtained in a non-invasive or minimally-invasive manner to detect blood glucose, can reduce the burden of a user, avoid the generation of wounds and reduce the infection risk.
Various modifications may be made by those skilled in the art without departing from the scope of the invention as defined by the appended claims.
Claims (13)
1. A blood glucose test device, comprising:
the carrier is provided with a liquid guide channel, a pressure chamber and a liquid storage chamber, the liquid guide channel comprises an inflow channel and a liquid storage channel which are arranged on the carrier in a mutually separated mode, the pressure chamber is communicated with the inflow channel and the liquid storage channel, and the liquid storage channel is communicated with the liquid storage chamber;
a flow-guiding actuator arranged on the carrier and used for sealing the pressure chamber;
the valve plate is arranged in the inflow channel and the liquid storage channel, the valve plate seals and isolates the inflow channel and the liquid storage channel so as to control the switching states of the inflow channel and the liquid storage channel, and when the flow guide actuator does not act, the valve plate seals and isolates the inflow channel and the liquid storage channel respectively;
a micro-needle patch which is attached to the carrier, is communicated with the inflow channel and is provided with a plurality of hollow micro-needles for minimally invasive insertion into human skin to draw tissue fluid;
a sensor, which is packaged on the carrier and is arranged in the liquid storage chamber to monitor a monitoring value of the blood sugar content in the tissue fluid; and
a control chip packaged on the carrier in a system to control the actuation of the flow-guiding actuator and receive the monitoring value of the sensor;
therefore, the microneedle patch is minimally invasive inserted into human skin by the hollow microneedles, the control chip controls the diversion actuator to actuate, a pressure difference is formed in the pressure chamber, the hollow microneedles are enabled to suck the interstitial fluid and are drawn to the inflow channel to be conveyed to the liquid storage chamber, the sensor monitors the monitoring value of the blood glucose content of the interstitial fluid, and finally the monitoring value is transmitted to the control chip, so that the control chip calculates monitoring information and provides user knowledge.
2. The blood glucose test device of claim 1, wherein the interstitial fluid is subcutaneous interstitial fluid of a human body.
3. The apparatus of claim 1, wherein the flow-guiding actuator comprises a carrier and an actuator, the carrier covers the pressure chamber and is attached to a surface of the pressure chamber, and the actuator is connected to a power source to deform and generate resonance with the carrier, so as to compress the volume of the pressure chamber to form a pumping force for delivering the interstitial fluid to the fluid reservoir.
4. The blood glucose test device of claim 3, wherein the actuating element is a piezoelectric element.
5. The device of claim 1, wherein the carrier has protrusions at the inlet channel and the reservoir channel to generate a pre-force against the valve plate to prevent backflow of tissue fluid.
6. The apparatus of claim 1, wherein the control chip comprises a graphene battery to provide power.
7. The device of claim 1, wherein the control chip comprises a transmission module for transmitting the monitoring information to an external device.
8. The apparatus of claim 7, wherein the transmission module is at least one of a USB, a mini-USB, and a micro-USB.
9. The apparatus of claim 7, wherein the transmission module is at least one of a Wi-Fi module, a bluetooth module, a radio frequency identification module, and a near field communication module.
10. The apparatus of claim 7, wherein the external device is at least one of a cloud system, a portable device, a computer system, a display device, an insulin injection device, and the like.
11. The blood glucose monitor device of claim 1, wherein each of the plurality of hollow microneedles of the microneedle patch has an inner diameter of 10-550 microns and a length of 400-900 microns.
12. The blood glucose monitor of claim 1, wherein the plurality of hollow microneedles are arranged in an array, and each of the plurality of hollow microneedles is spaced more than 200 μm apart from each other.
13. The blood glucose test device of claim 1, wherein the plurality of hollow microneedles are made of a silica material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711159824.3A CN109805939B (en) | 2017-11-20 | 2017-11-20 | Blood sugar detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711159824.3A CN109805939B (en) | 2017-11-20 | 2017-11-20 | Blood sugar detection device |
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| CN109805939A CN109805939A (en) | 2019-05-28 |
| CN109805939B true CN109805939B (en) | 2022-05-10 |
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| CN201711159824.3A Active CN109805939B (en) | 2017-11-20 | 2017-11-20 | Blood sugar detection device |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| CN1916639A (en) * | 2005-07-28 | 2007-02-21 | 生命扫描苏格兰有限公司 | Method for feedback control of a microfluidic system |
| CN101377192A (en) * | 2007-08-30 | 2009-03-04 | 研能科技股份有限公司 | Fluid delivery device |
| CN106110491A (en) * | 2016-07-22 | 2016-11-16 | 京东方科技集团股份有限公司 | Administration device |
| CN208447604U (en) * | 2017-11-20 | 2019-02-01 | 研能科技股份有限公司 | Blood sugar detection apparatus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012149155A1 (en) * | 2011-04-29 | 2012-11-01 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
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- 2017-11-20 CN CN201711159824.3A patent/CN109805939B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6558361B1 (en) * | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| CN1916639A (en) * | 2005-07-28 | 2007-02-21 | 生命扫描苏格兰有限公司 | Method for feedback control of a microfluidic system |
| CN101377192A (en) * | 2007-08-30 | 2009-03-04 | 研能科技股份有限公司 | Fluid delivery device |
| CN106110491A (en) * | 2016-07-22 | 2016-11-16 | 京东方科技集团股份有限公司 | Administration device |
| CN208447604U (en) * | 2017-11-20 | 2019-02-01 | 研能科技股份有限公司 | Blood sugar detection apparatus |
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| CN109805939A (en) | 2019-05-28 |
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