CN109805391A - A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form - Google Patents
A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form Download PDFInfo
- Publication number
- CN109805391A CN109805391A CN201910174135.2A CN201910174135A CN109805391A CN 109805391 A CN109805391 A CN 109805391A CN 201910174135 A CN201910174135 A CN 201910174135A CN 109805391 A CN109805391 A CN 109805391A
- Authority
- CN
- China
- Prior art keywords
- tablet
- whitening
- capsule
- soft capsule
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention relates to food technology fields, more particularly to a kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form, the whitening food formulation is made of tablet and soft capsule, and the tablet is grouped as by the group of following weight percentage: l-cysteine 20 ~ 40%；Vitamin C 20 ~ 40%；Grape seed extract 4 ~ 8%；Se-enriched yeast 1.5 ~ 4%；Niacinamide 0.5 ~ 2%；Sodium Hyaluronate 0.5 ~ 2%；Olive extract 0.5 ~ 2%；Microcrystalline cellulose 10 ~ 35%；Magnesium stearate 0.1 ~ 1%；The content of the soft capsule is grouped as by the group of following weight percentage: vitamin E 20 ~ 40%；Haematococcus pluvialis extract 10 ~ 20%；Co-Q10 5 ~ 20%；Rosmarinus officinalis extract 4 ~ 8%；Soybean oil 40 ~ 60%.The present invention is classified according to the heterogeneity of whitening food Effect raw material, and tablet and soft capsule is respectively prepared, and improves the stability, trap and bioavilability of each Effect raw material, so that white-skinned face function bigizationner of raw material.
Description
Technical field
The present invention relates to food technology field more particularly to a kind of whitening food systems containing tablet and capsule dual dosage form
Agent and its instructions of taking.
Background technique
With society, economical fast development and continuous improvement of people's living standards, people to itself appearance also further
Concern, it is further strong to the pursuit of beautiful appearance, for the yellow race crowd of Asia, the glossy sight for beauty with skin and muscles are fair
Thought is widely recognized as and is praised highly, thus the product with white-skinned face function early have become that beauty product industry can not ignore it is important thin
Divide category, the market demand is huge.
Human body complexion is mainly related with epidermal melanin content.Melanin synthesizes in people's epidermal melanocytes, at present
Generally acknowledged route of synthesis are as follows: tyrosine → DOPA → DOPA quinone → dopachrome → dihydroxy indole → keto-acid indoles → black
Element, and tyrosinase is the key enzyme for being catalyzed above-mentioned steps；In addition, the factors such as ultraviolet light, air pollution, emotional stress can make
A large amount of oxyradicals are generated in human body, free radical meeting stimulation melanin cell simultaneously promotes its to generate melanin.Therefore skin beauty
White to be realized by following several approach: 1. inhibit tyrosinase activity to reduce the generation of melanin；2. reduction or transfer are
Melanin through generating is to reduce melanin pigmentation；3. the damage of pair resisting oxidation free radical, referred to as " anti-oxidant "；Change 4. giving
The nutritional ingredient of kind Skin Cell life condition, for example Co-Q10, microelement, hyaluronic acid etc., make skin keep good
Metabolism and self-repairing capability.
Within a very long time in past, whitening product in the market is almost external application smear type product, for example whitening entirely
Essence, whitening emulsion, whitening mask etc.；But in recent years, although external application smear type product still occupies predominantly on the market
Position, it is interior with oral type whitening product but because the mechanism in it in adjusting is more basic, it is convenient to take mode, has both other health care function
Effect, side effect is smaller etc., and advantages gradually rise and receive for consumer and welcome, the market demand just rise year by year.
At present on domestic and international market, there are a plurality of interior oral type whitening products, the function of skin-whitening can be promoted
It can food.In terms of dosage form angle, it only includes single formulation in whitening product that single-piece, which takes orally, in the market, and mostly pure tablet is few
Number is pure capsule (mostly hard capsule)；In terms of raw material angle, having listed commonly used Effect raw material in oral whitening product has:
Glutathione, vitamin C, l-cysteine, L-cysteine, vitamin B complex, grape seed extract, Punica granatum L. extract, fructus rosae
Extract, resveratrol, tomato extract, hesperetin, Turmeric P.E, Co-Q10, vitamin E, haematococcus pluvialis extract
Deng.
It is worth noting that, there is certain differences, such as part material for the physicochemical property of above-mentioned common Effect raw material
It is water-soluble, and another part is fat-soluble；Part material is more stable, and part material physicochemical property is unstable, is easy
It is oxidized.When carrying out product forms design, if not considering the difference of each Effect raw material physicochemical property, only simply will
Each Effect raw material all mixes, and adds auxiliary material, the solid pharmaceutical preparation being uniformly compressed into tablet form (i.e. tablet), or be filled in hollow
The way of hard capsule is made in capsule, is detrimental to each raw material and gives full play to effect.Moreover, from the point of view of consumer feedback, greatly
The whitening function food of amount single formulation does not allow consumer to experience apparent whitening effect, therefore dosage form is single, leads to effect
It is the current biggish technological deficiency of whitening function food that raw material, which is unable to give full play its white-skinned face function, and the present invention is perfect
With the one aspect of breakthrough.
On the other hand, above-mentioned common raw material reaches the approach of white-skinned face function or by inhibiting tyrosinase activity, or
By restoring generated melanin, and or by anti-oxidant, but can shift the effect of having generated melanin raw material or
The nutritional ingredient such as Co-Q10 and microelement etc. that Skin Cell life condition can be improved rarely have and are used for whitening function food
In product, thus contained raw material do not cover comprehensively various feasible whitening approach be currently on the market whitening function food in technical formula
On deficiency, and the another aspect to be improved and be broken through of the invention.
Summary of the invention
The present invention is single in order to overcome traditional whitening food formulation dosage form, and Effect raw material is caused to be unable to give full play its whitening
The problem of effect, provides a kind of whitening food formulation containing tablet and capsule dual dosage form, double on the market at present to make up
The blank of heavy prescription type whitening food and the action pathway for expanding whitening function food, give full play to its white-skinned face function.
The present invention also provides a kind of instructions of taking of whitening food formulation containing tablet and capsule dual dosage form.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of tablet and soft capsule, the tablet by with
The group of lower weight percentage is grouped as:
L-cysteine 20 ~ 40%；
Vitamin C 20 ~ 40%；
Grape seed extract 4 ~ 8%；
Se-enriched yeast 1.5 ~ 4%；
Niacinamide 0.5 ~ 2%；
Sodium Hyaluronate 0.5 ~ 2%；
Olive extract 0.5 ~ 2%；
Microcrystalline cellulose 10 ~ 35%；
Magnesium stearate 0.1 ~ 1%；
The content of the soft capsule is grouped as by the group of following weight percentage:
Vitamin E 20 ~ 40%；
Haematococcus pluvialis extract 10 ~ 20%；
Co-Q10 5 ~ 20%；
Rosmarinus officinalis extract 4 ~ 8%；
Soybean oil 40 ~ 60%.
The whitening food formulation that the present invention contains tablet and capsule dual dosage form prepare according to conventional methods in the art and
At.Design principle of the invention are as follows: contained raw material is water soluble ingredient in tablet, in addition to vitamin C is easier to be oxidized,
His ingredient stability is preferable, is not easy to be oxidized or volatilize, and is consequently adapted to that tablet is made；In addition, low containing several contents in tablet
In 5% ingredient, Tabules are selected, relies on its stable processing technique, accurate measurement, different batches of product each component can be made to contain
It is very low to measure deviation, uniformity is high, is suitable for the formula containing a small amount of or micro adding ingredient；
Contained raw material is liposoluble constituent in soft capsule, and is stronger antioxidant content, is easily oxidized in air, institute
To be unsuitable for addition in tablets, therefore soybean oil is chosen as solvent by above-mentioned four kinds of dissolution of raw material, be sealed in soft capsule material
Soft capsule is made.Internal finish and external soft capsule shell can prevent well raw material therein directly contacted with air and
It is reacted with oxygen, to effectively stabilize the above ingredient and protect its anti-oxidation efficacy；In addition, soft capsule compared with for tablet not
It is influenced vulnerable to gastric acid and is disintegrated in enteron aisle faster than tablet, therefore availability can be made in the trap and organism of component content more
Height, more conducively its performance white-skinned face function.
Contained Effect raw material and its action pathway of corresponding whitening are as follows in inventive formulation:
L-cysteine, vitamin C, vitamin E: it inhibits tyrosinase activity to reduce the generation of melanin.L-cysteine is in people
It can be decomposed into L-cysteine in vivo, L-cysteine, vitamin C and vitamin E can inhibit tyrosinase activity, to press down
Tyrosine processed is eventually converted into melanin, the final generation for reducing melanin；
Co-Q10, vitamin E, Se-enriched yeast (selenium element), grape seed extract, olive extract, haematococcus pluvialis extract
Object, Rosmarinus officinalis extract: strong antioxidant action.Co-Q10 can remove intracorporal oxygen radical, play antioxidation；Dimension life
Plain E is also the intracorporal powerful antioxidant of people；Selenium in Se-enriched yeast is the important antioxygen for constituting human body as a kind of microelement
Change the active constituent of enzyme-glutathione peroxidase (GSH-Px)；Grape seed extract main active is former cyanine
Element, olive extract main active are hydroxytyrosol, and the main active of haematococcus pluvialis extract is astaxanthin, fan
Repeatedly the main active of fragrant extract is rosmanol, carnosol and carnosic acid, and mentioned component is to possess relatively strong resist
The active skull cap components of oxidizing force, wherein astaxanthin is even more one of strongest natural in the world.Mentioned component is with each
It is ingested from suitable dosage form, the intracorporal whole antioxidant levels of people can be obviously improved, so that caused by because of free radical stimulation
The generation of melanin substantially reduces, to reach more significant whitening effect；
Vitamin C, niacinamide: the melanin that reduction or transfer have generated.Vitamin C can will have been generated because of its strong reducing property
Melanin reduction, so that the melanin reduced in skin reaches whitening purpose；And niacinamide then can will be generated and to skin
The mobile melanin in skin surface layer is shifted, and melanin is hindered to reach skin surface and show deeper color to play whitening
Effect；
Co-Q10, Se-enriched yeast (selenium element), Sodium Hyaluronate: improve Skin Cell life condition, promote the new of Skin Cell
Old metabolism and self-repairing capability.Co-Q10 not only has stronger inoxidizability, while it is important as one kind in human body
Coenzyme is adjustable Skin Cell breathing, promotes skin cell metabolism, helps to maintain the skin regeneration period, slows down skin
Aging；Similarly, the selenium element in Se-enriched yeast can not only play antioxidation indirectly, moreover it is possible to improve the oxygen carrying energy of red blood cell
Power brings more sufficient oxygen for Skin Cell, enhances the metabolic capabilities of skin；Sodium Hyaluronate can be protected for Skin Cell
Water holding point, improves the growing environment of Skin Cell, promotes dermal cell growth, differentiation, reconstruction and self-regeneration to reach
Effect.And the promotion of skin cell metabolism and self-repairing capability can play skin to free radical resisting and removing melanin
Strong auxiliary pushing effect, promotes skin-whitening indirectly.
Recipe ingredient of the invention is an entirety, has following synergistic function between partial efficacy raw material:
(1) synergistic function of vitamin E and selenium element:
Vitamin E is a kind of intracorporal powerful antioxidant of people, is present on cell membrane, the free radical on energy scavenger-cell film, from
And inhibit the oxidation of unsaturated fatty acid on cell membrane, antioxidation is mainly played on cell membrane, constitutes cell antioxygen
The first line of defence of change；And selenium element is the essential trace elements of the human body, while being also glutathione peroxidase (GSH-
Px active constituent), GSH-Px are the enzymes in cytoplasm with important antioxidation, can be neutralized into intracytoplasmic freedom
Base prevents oxidation of the free radical to unsaturated fatty acid in cytoplasm, to play antioxidation in cytoplasm, constitutes thin
The oxidation resistant second defence line of born of the same parents.Therefore vitamin E and selenium are by acting in unsaturated fatty acid peroxidization chain not
Collaboration antioxidation is played in human body with stage and position；In addition, selenium still maintains the required micro of pancreas function
Element, the trypsase and pancreatic lipase of pancreatic secretion facilitate the digestion and absorption of fat, to promote the absorption of vitamin E.
The two is mutually promoted by both the above mechanism, achievees the purpose that enhance anti-oxidant, whitening effect jointly；
(2) synergistic function of vitamin C and vitamin E:
Vitamin C is a kind of intracorporal water soluble vitamin of people, and significant feature is exactly its strong reducing property.When vitamin E exists
It reacts after generating tocopherol hydroxy radical compound in human body with free radical, this compound can be reduced into dimension by vitamin C
Raw element E, so that vitamin E be helped to continue to play anti-oxidant with other physiological actions, therefore vitamin C and vitamin E in human body
There is synergy in antioxidation, the two can promote the whitening effect of formula with using；Meanwhile there are also join for the two
Close immunoregulatory function.
A kind of instructions of taking of the whitening food formulation containing tablet and capsule dual dosage form are as follows: the dose of the tablet
It is 300 ~ 500 mg/ time, 2 times/day；The dose of the content of the soft capsule is 150 ~ 300 mg/ time, 2 times/day.
Preferably, calculating by weight 50kg, the taking dose of daily tablet is 12 ~ 20mg/kg；Soft capsule is interior daily
Tolerant taking dose is 6 ~ 12mg/kg.
Therefore, the invention has the following beneficial effects:
(1) present invention is classified according to the heterogeneity of whitening food Effect raw material, tablet and soft capsule is respectively prepared, mentioned
High stability, trap and the bioavilability of each Effect raw material, so that white-skinned face function bigizationner of raw material；
(2) the white-skinned face function raw material chosen of the present invention, action pathway more existing similar product more fully, and part
Can also be synergistic between raw material, enhance whitening effect.
Specific embodiment
Below by specific embodiment, the technical solutions of the present invention will be further described.
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is unless otherwise instructed conventional method in that art.
Embodiment 1
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of, tablet is by following heavy tablet and soft capsule
The group of amount percentage composition is grouped as:
L-cysteine 30%；
Vitamin C 20%；
Grape seed extract 4.0%；
Se-enriched yeast 4.0%；
Niacinamide 2.0%；
Sodium Hyaluronate 2.0%；
Olive extract 2.0%；
Microcrystalline cellulose 35.0%；
Magnesium stearate 1.0%；
The content of soft capsule is grouped as by the group of following weight percentage:
Vitamin E 25.0%；
Haematococcus pluvialis extract 12.5%；
Co-Q10 8.3%；
Rosmarinus officinalis extract 4.2%；
Soybean oil 50.0%.
Above-mentioned tablet according to conventional methods in the art, through pretreatment of raw material, mix, softwood processed, granulation, drying, whole grain,
Tablet non-discolouring after a period of time is made in the Conventional process steps such as tabletting；Above-mentioned soft capsule according to this field routine side
Gelatin, glycerol and purified water are mixed to get glue by method, at the same by each component according to said ratio weighing, mixing after, obtain in
Glue and content feed liquid are carried out pelleting processing, obtain soft capsule by tolerant feed liquid；It obtains containing dual dose of tablet and capsule
The whitening food formulation of type.
The instructions of taking of whitening food formulation containing tablet and capsule dual dosage form made from the present embodiment is, tablet
Dose is 500 mg/ time, 2 times/day；The dose of the content of soft capsule is 240 mg/ time, 2 times/day.By body weight
50kg(chooses 50kg because whitening food consumption person is mostly women) it calculates, then human body tablet dose is 20 mg/(kg* days),
Soft capsule content dosage is 9.6mg/(kg* days).
Embodiment 2
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of, tablet is by following heavy tablet and soft capsule
The group of amount percentage composition is grouped as:
L-cysteine 40%；
Vitamin C 31.9%；
Grape seed extract 8%；
Se-enriched yeast 4%；
Niacinamide 2%；
Sodium Hyaluronate 2%；
Olive extract 2%；
Microcrystalline cellulose 10%；
Magnesium stearate 0.1%；
The content of soft capsule is grouped as by the group of following weight percentage:
Vitamin E 20%；
Haematococcus pluvialis extract 10%；
Co-Q10 20%；
Rosmarinus officinalis extract 8%；
Soybean oil 42%.
Above-mentioned tablet and soft capsule are prepared according to conventional methods in the art, contain tablet and glue with embodiment 1
The whitening food formulation of capsule dual dosage form.
The instructions of taking of whitening food formulation containing tablet and capsule dual dosage form made from the present embodiment is, tablet
Dose is 300 mg/ time, 2 times/day；The dose of the content of soft capsule is 300 mg/ time, 2 times/day.By body weight
50 kg(choose 50kg because whitening food consumption person is mostly women) it calculates, then human body tablet dose is 12 mg/(kg* days),
Soft capsule content dosage is 12 mg/(kg* days).
Embodiment 3
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of, tablet is by following heavy tablet and soft capsule
The group of amount percentage composition is grouped as:
L-cysteine 20%；
Vitamin C 40%；
Grape seed extract 6%；
Se-enriched yeast 3%；
Niacinamide 1.5%；
Sodium Hyaluronate 1.5%；
Olive extract 1.5%；
Microcrystalline cellulose 26.35%；
Magnesium stearate 0.15%；
The content of soft capsule is grouped as by the group of following weight percentage:
Vitamin E 29%；
Haematococcus pluvialis extract 20%；
Co-Q10 5%；
Rosmarinus officinalis extract 6%；
Soybean oil 40%.
Above-mentioned tablet and soft capsule are prepared according to conventional methods in the art, contain tablet and glue with embodiment 1
The whitening food formulation of capsule dual dosage form.
The instructions of taking of whitening food formulation containing tablet and capsule dual dosage form made from the present embodiment is, tablet
Dose is 400 mg/ time, 2 times/day；The dose of the content of soft capsule is 150 mg/ time, 2 times/day.By body weight
50kg(chooses 50kg because whitening food consumption person is mostly women) it calculates, then human body tablet dose is 16 mg/(kg* days),
Soft capsule content dosage is 6 mg/(kg* days).
Embodiment 4
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of, tablet is by following heavy tablet and soft capsule
The group of amount percentage composition is grouped as:
L-cysteine 33%；
Vitamin C 20%；
Grape seed extract 8%；
Se-enriched yeast 4%；
Niacinamide 2%；
Sodium Hyaluronate 2%；
Olive extract 2%；
Microcrystalline cellulose 28%；
Magnesium stearate 1%；
The content of the soft capsule is grouped as by the group of following weight percentage:
Vitamin E 20%；
Haematococcus pluvialis extract 11%；
Co-Q10 5%；
Rosmarinus officinalis extract 4%；
Soybean oil 60%.
Above-mentioned tablet and soft capsule are prepared according to conventional methods in the art, contain tablet and glue with embodiment 1
The whitening food formulation of capsule dual dosage form.
The instructions of taking of whitening food formulation containing tablet and capsule dual dosage form made from the present embodiment is, tablet
Dose is 450 mg/ time, 2 times/day；The dose of the content of soft capsule is 300 mg/ time, 2 times/day.By body weight
50kg(chooses 50kg because whitening food consumption person is mostly women) it calculates, then human body tablet dose is 14.4 mg/(kg*
It), soft capsule content dosage is 12 mg/(kg* days).
Embodiment 5
A kind of whitening food formulation containing tablet and capsule dual dosage form, is made of, tablet is by following heavy tablet and soft capsule
The group of amount percentage composition is grouped as:
L-cysteine 25%；
Vitamin C 37%；
Grape seed extract 7%；
Se-enriched yeast 1.5%；
Niacinamide 0.5%；
Sodium Hyaluronate 0.5%；
Olive extract 0.5%；
Microcrystalline cellulose 27.2%；
Magnesium stearate 0.8%；
The content of the soft capsule is grouped as by the group of following weight percentage:
Vitamin E 40%；
Haematococcus pluvialis extract 10%；
Co-Q10 5%；
Rosmarinus officinalis extract 5%；
Soybean oil 40%.
Above-mentioned tablet and soft capsule are prepared according to conventional methods in the art, contain tablet and glue with embodiment 1
The whitening food formulation of capsule dual dosage form.
The instructions of taking of whitening food formulation containing tablet and capsule dual dosage form made from the present embodiment is, tablet
Dose is 500 mg/ time, 2 times/day；The dose of the content of soft capsule is 150 mg/ time, 2 times/day.By body weight
50kg(chooses 50kg because whitening food consumption person is mostly women) it calculates, then human body tablet dose is 20 mg/(kg* days),
Soft capsule content dosage is 6 mg/(kg* days).
To the tablet and soft capsule in the whitening food formulation containing tablet and capsule dual dosage form obtained in embodiment 1
Content carries out Mouse oral test, measures the joint oxidation resistance of its tablet and soft capsule.
Test explanation:
Reduced glutathione (GSH) is a kind of low molecule scavenger, it can remove O2 -、H2O2,LOOH.Glutathione is paddy ammonia
A kind of tripeptides of acid, glycine and cysteine composition, is the sulfhydryl compound of main nonprotein in tissue, is GSH-Px
Required for both enzyme hydroperoxide decompositions with the substrate of two kinds of enzymes of GST, it can stablize the enzyme containing sulfydryl, and prevent
Hemoglobin and other confactor oxidative damages lack or exhaust that GSH can promote many chemical substances or environmental factor to produce
Raw intoxication, GSH amount number be measurement antioxidant ability of organism size important indicator.GSH content is higher in blood, mentions
Show that antioxidant ability of organism is stronger；On the contrary, GSSG is oxidized form of glutathione, content is higher, prompts antioxidant ability of organism
It is weaker.The intracorporal oxidation resistance of machine is directly related with skin-whitening, and oxidation resistance is stronger, i.e. the Scavenging activity of free radical is got over
By force, the melanin production in skin is more suppressed, and then the colour of skin is more towards fair and clear.
The principle of oxidation of ethanol damage model: ethyl alcohol is largely taken in, and activation oxygen molecule generates free radicals, and leads to histocyte
The exhaustion of peroxidating effect and internal reductive glutathione.
Test method:
Female ICR mice of the weight between 28-31g 24 is taken, is equally divided into 4 groups, every group 6, sub-cage rearing;
One, intragastric administration on mice test grouping situation and corresponding operating are as follows:
(1) formula group:
Gained tablet and soft capsule content in embodiment 1, with human body amount tablet 1000 mg/ days, soft capsule content
480 mg/ days be Dose standard to be tested, by body weight 50kg(because whitening food consumption person is mostly women, thus choose
It 50kg) calculates, then human body tablet dose is 20 mg/ (kg* days), and soft capsule content dosage is 9.6 mg/ (kg* days).Small
In the oral experiment of mouse, using 10 multiple doses of human dose, i.e., according to 200 mg/ of tablet (kg* days), soft capsule content 96
The standard of mg/ (kg* days) carries out stomach-filling operation to mouse and continues 7 days one time a day.7th day evening overnight fasting, secondary morning stomach-filling
50% ethyl alcohol 12ml/kg, modeling establish model of oxidative, take whole blood after 6 hours；
(2) the competing product group of Japan:
The competing product are pure Tabules, recommend daily intaking amount as standard using the people of the competing product, by body weight 50kg, calculate list
Position weight daily intaking amount, it is using 10 multiple doses of the dosage, tablet is soluble in water, to mouse carry out stomach-filling operation, daily 1
It is secondary, continue 7 days.Model of oxidative is established in 7th day evening overnight fasting, secondary 50% ethyl alcohol 12ml/kg of morning stomach-filling, modeling, and 6 is small
When after take whole blood；
(3) model of oxidative group:
Stomach-filling operation is carried out to mouse with pure water and continues 7 days one time a day.7th day evening overnight fasting, secondary 50% second of morning stomach-filling
Alcohol 12ml/kg, modeling establish model of oxidative, take whole blood after 6 hours；
(4) blank group:
Stomach-filling operation is carried out to mouse with pure water and continues 7 days one time a day.7th day evening overnight fasting, secondary morning is without ethyl alcohol
Stomach-filling took whole blood after 6 hours.
Two, GSH, GSSG index determining
(1) GSH the and GSSG stock solution of 1mg/ml is diluted to various concentration, be measured, draw standard curve；
(2) blood sample is handled: in the centrifuge tube for taking blood 100-200 μ l to infiltrate to heparin sodium, being placed in 4 °C, is divided 2 parts, 1. 50 μ
+ 50 μ l PBS of l whole blood, 2.+50 μ l NEM of 50 μ l whole blood, is uniformly mixed, and 100 μ l, 10% trichloroacetic acid precipitation albumen is added
Matter, sufficiently 12000g is centrifuged 10min after oscillation, takes supernatant, measures immediately, whole process is maintained at 4 °C of progress；
(3) GSH is measured: taking 10 μ l samples, 0.1M Na is added2HPO410 μ l are added in 180 μ l of -0.005M edta buffer liquid
OPT solution mixes well and is protected from light 30min, measures fluorescence intensity, and calculate respective concentration according to standard curve；
(4) GSSG is measured: taking 10 μ l samples, 180 μ l of 0.1M NaOH is added, 10 μ l OPT solution are added, mixes well and is protected from light
30min is reacted, measures fluorescence intensity, and respective concentration is calculated according to standard curve.
Test result:
GSH and GSSG concentration in table 1- Mouse whole blood
Note: formula group has statistical difference compared with Japanese competing product group, model of oxidative group:
* p < 0.001 p < 0.05, * * *
If table 1 can obtain, the present invention, which contains tablet and the whitening food formulation of soft capsule dual dosage form, can significantly improve mouse blood
In GSH(reduced glutathione) content, reduce GSSG(oxidized form of glutathione) content, be obviously improved GSH/GSSG ratio
Value significantly improves the intracorporal antioxidant levels of mouse, and antioxidation is significantly better than certain Japanese competing product.It is based on anti-oxidant
The important channel of whitening, therefore the deducibility present invention has because of the material combination of unique double-formulation design and multiple whitening approach
The stronger whitening effect for being significantly better than certain Japanese competing product.
The test method of the whitening food formulation containing tablet and capsule dual dosage form of embodiment 2-5 and 1 phase of embodiment
Together, quite, details are not described herein for test result and embodiment 1.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the present invention in any form, and is not surpassing
There are also other variations and modifications under the premise of technical solution documented by claim out.
Claims (3)
1. a kind of whitening food formulation containing tablet and capsule dual dosage form, which is characterized in that it is made of tablet and soft capsule,
The tablet is grouped as by the group of following weight percentage:
L-cysteine 20 ~ 40%；
Vitamin C 20 ~ 40%；
Grape seed extract 4 ~ 8%；
Se-enriched yeast 1.5 ~ 4%；
Niacinamide 0.5 ~ 2%；
Sodium Hyaluronate 0.5 ~ 2%；
Olive extract 0.5 ~ 2%；
Microcrystalline cellulose 10 ~ 35%；
Magnesium stearate 0.1 ~ 1%；
The content of the soft capsule is grouped as by the group of following weight percentage:
Vitamin E 20 ~ 40%；
Haematococcus pluvialis extract 10 ~ 20%；
Co-Q10 5 ~ 20%；
Rosmarinus officinalis extract 4 ~ 8%；
Soybean oil 40 ~ 60%.
2. a kind of instructions of taking of the whitening food formulation as described in claim 1 containing tablet and capsule dual dosage form,
It is characterized in that, the dose of the tablet is 300 ~ 500 mg/ time, 2 times/day；The dose of the content of the soft capsule is
150 ~ 300 mg/ times, 2 times/day.
3. the instructions of taking of the whitening food formulation according to claim 2 containing tablet and capsule dual dosage form, special
Sign is, calculates by 50 kg of weight, and the taking dose of daily tablet is 12 ~ 20mg/kg；The clothes of the content of daily soft capsule
It is 6 ~ 12 mg/kg with dosage.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910174135.2A CN109805391A (en) | 2019-03-08 | 2019-03-08 | A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form |
| JP2019194212A JP6933327B2 (en) | 2019-03-08 | 2019-10-25 | A dual-form whitening food preparation containing a type of tablet and capsule, and how to take it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910174135.2A CN109805391A (en) | 2019-03-08 | 2019-03-08 | A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109805391A true CN109805391A (en) | 2019-05-28 |
Family
ID=66608425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910174135.2A Pending CN109805391A (en) | 2019-03-08 | 2019-03-08 | A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6933327B2 (en) |
| CN (1) | CN109805391A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209051A (en) * | 2021-12-24 | 2022-03-22 | 江西熙帝生物科技有限公司 | Oral whitening composition containing beet composite plant enzyme and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113632992A (en) * | 2021-09-07 | 2021-11-12 | 何泽剑 | Skin beautifying food formula and preparation method of buccal tablets thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101978975A (en) * | 2010-11-16 | 2011-02-23 | 云南绿A生物工程有限公司 | Haematococcus extract preparation, and preparation method and use thereof |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN108888601A (en) * | 2018-08-02 | 2018-11-27 | 济源希健生物医药科技发展有限公司 | A kind of vitamin E selenium microcapsules tablet, preparation method and its usage |
| CN108902958A (en) * | 2018-07-20 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of astaxanthin soft capsule and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3165262B2 (en) * | 1992-09-30 | 2001-05-14 | 保土谷アシュランド株式会社 | Binder composition for casting, composition for casting, and method for producing casting mold |
| JP2005170834A (en) * | 2003-12-10 | 2005-06-30 | Taiyo Yakuhin Kogyo Kk | Skin ameliorating preparation |
| JP5191150B2 (en) * | 2007-03-19 | 2013-04-24 | 小林製薬株式会社 | A food composition having a solid dosage form containing miwillow as an active ingredient |
| GB2458466A (en) * | 2008-03-18 | 2009-09-23 | Kartar Singh Lalvani | Composition for hair, skin and nail health maintenance |
-
2019
- 2019-03-08 CN CN201910174135.2A patent/CN109805391A/en active Pending
- 2019-10-25 JP JP2019194212A patent/JP6933327B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101978975A (en) * | 2010-11-16 | 2011-02-23 | 云南绿A生物工程有限公司 | Haematococcus extract preparation, and preparation method and use thereof |
| CN104055122A (en) * | 2014-07-09 | 2014-09-24 | 江西维莱营健高科有限公司 | Haematococcus pluvialis and blueberry extract soft capsules and preparation method thereof |
| CN108902958A (en) * | 2018-07-20 | 2018-11-30 | 深圳市博奥生物科技有限公司 | A kind of astaxanthin soft capsule and preparation method thereof |
| CN108888601A (en) * | 2018-08-02 | 2018-11-27 | 济源希健生物医药科技发展有限公司 | A kind of vitamin E selenium microcapsules tablet, preparation method and its usage |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114209051A (en) * | 2021-12-24 | 2022-03-22 | 江西熙帝生物科技有限公司 | Oral whitening composition containing beet composite plant enzyme and application thereof |
| CN114209051B (en) * | 2021-12-24 | 2024-01-26 | 江西熙帝生物科技有限公司 | Oral whitening composition containing beet composite plant ferment and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020141652A (en) | 2020-09-10 |
| JP6933327B2 (en) | 2021-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3240555B1 (en) | Multi-supplement compositions | |
| Prakash et al. | Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases | |
| US20070190209A1 (en) | All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization | |
| US8642030B2 (en) | Compositions containing coenzyme Q-10 and dihydrolipoic acid | |
| US20070088086A1 (en) | Method of using synthetic L-Se-methylselenocysteine as a nutriceutical and a method of its synthesis | |
| JP2005535617A (en) | Use of taurine to treat alopecia | |
| CN101500991A (en) | Lipoic acid derivatives | |
| CN109805391A (en) | A kind of whitening food formulation and its instructions of taking containing tablet and capsule dual dosage form | |
| CN108208417A (en) | Pet anti-oxidant nutritional agents and preparation method thereof | |
| CN106360666A (en) | Astaxanthin-containing anti-oxidation nutritional health product | |
| CN108186384A (en) | A kind of mouthwash and preparation method thereof | |
| Kim | Effects of H3O-fraction of Dioscorea japonica Thunb and selenium on lipid peroxidation in streptozotocin-induced diabetic rats | |
| KR100447441B1 (en) | Skin whitening agent containing bird's nest extract as tyrosinase inhibiting agent as main component and albutin or kojic acid as auxiliary component | |
| EP1870095A1 (en) | Composition for increasing anti-oxidation activity in blood | |
| KR20170052556A (en) | Cosmetic compositions for improving skin aging or skin moisturizing comprising fucosterol | |
| JP2007056219A (en) | Antioxidant composition | |
| US20200338153A1 (en) | Anaerobic antioxidant composition | |
| Nandi et al. | Role of co-administration of antioxidants in prevention of oxidative injury following sub-chronic exposure to arsenic in rats | |
| CN112931812B (en) | High-stability oral whitening preparation and preparation method thereof | |
| JP4804729B2 (en) | Composition for improving peripheral blood circulation | |
| CA3041914C (en) | Anaerobic antioxidant composition | |
| JP2005015387A (en) | Antioxidative composition | |
| RO137742A0 (en) | Innovative formula of an orally administered product with complex composition based on hyaluronic acid and astaxanthin with photoprotective, antioxidant and antiage role - food supplement | |
| EP3733197A1 (en) | Anaerobic antioxidant composition | |
| CA3131653A1 (en) | Antioxidant composition comprising polydatin and acetylcysteine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190528 |
|
| RJ01 | Rejection of invention patent application after publication |