CN109796507A - The aurantiamarin remaking the preparation method of aurantiamarin and being prepared - Google Patents
The aurantiamarin remaking the preparation method of aurantiamarin and being prepared Download PDFInfo
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- CN109796507A CN109796507A CN201910137553.4A CN201910137553A CN109796507A CN 109796507 A CN109796507 A CN 109796507A CN 201910137553 A CN201910137553 A CN 201910137553A CN 109796507 A CN109796507 A CN 109796507A
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Abstract
The invention discloses a kind of preparation method for remaking aurantiamarin and the aurantiamarins being prepared.Remake the preparation method of aurantiamarin, comprising the following steps: impregnated with lye to light aurantiamarin processed, obtain feed liquid；Feed liquid and lye in step 1) carries out to moment in such a way that pressurization liquidates to be mixed, and mixed liquor is obtained；Mixed liquor in step 2) is separated by solid-liquid separation, is dried, recasting aurantiamarin is obtained.The preparation method of recasting aurantiamarin of the invention, by that light aurantiamarin crystal processed after alkali is impregnated, liquidated, intramolecular-OH can be destroyed and form hydrogen bond or covalent bond, charge is made to disappear, reduce intermolecular repulsion, reduce intermolecular distance, bulk density becomes larger.The recasting aurantiamarin that the preparation method of aurantiamarin obtains is remake, heap density becomes larger, so that product is easier to transport, reduces packaging and transportation cost, substantially reduces dust explosion risk.
Description
Technical field
The present invention relates to aurantiamarins to extract field, particularly, is related to a kind of preparation method for remaking aurantiamarin.In addition, this
The aurantiamarin that invention further relates to a kind of preparation method including above-mentioned recasting aurantiamarin and is prepared.
Background technique
Aurantiamarin be prevalent in the leaf of the citrus kind of bitter orange, sweet orange, Wenzhou dried immature fruit of citron orange and other Rutaceae, bark,
It is one of main flavonoids in tangerine peel in colored and discarded pericarp.The leftover bits and pieces of citrus fruit per ton such as pericarp, fruit
The aurantiamarin of 10kg~15kg can be obtained in meat etc..With fruit grow up and it is mature, the content of aurantiamarin is decreased obviously, and diameter is
The aurantiamarin that the fruit of 1.5cm~2cm contains accounts for 20% of dry weight or more, but when diameter increases to the fruit of 2.5cm~3.5cm
The aurantiamarin contained in fact accounts for 15% or less dry weight.Other than citrus, there is also aurantiamarins in other plants, such as in beans
Section, Labiatae, all exists in rutaceae Betulaceae, these plants are grown on Hongkong mostly.In addition, being grown in uncommon
Also there is the existing report of aurantiamarin in the root of the cured short Ji of two species and angle Ji and Sichuan Province's wilsonii.
Aurantiamarin is tasteless odorless, and sterling is in Microelements in Hair acicular crystal, and color is white or faint yellow, and melting range is 258
DEG C~260 DEG C.Molecular formula is C28H34O15, molecular weight 610.5.It is readily soluble in alkaline solution and pyridine, obtains clear Huang
Color solution is slightly soluble in methanol, glacial acetic acid, is practically insoluble between propyl alcohol, benzene and chloroform, is acicular crystallization in dilute acetic acid.
Open loop forms chalcone in alkaline solution, is flaxen crystallization.Since aurantiamarin and other similar glycocide compositions are multiple
Miscellaneous crystal largely influences its solubility and other physical properties, so hardly resulting in its standard items.
The physiological function that there are many aurantiamarins: 1, aurantiamarin effect to vascular system, earlier studies have shown that, plant is yellow
Ketone can reduce capillary wall permeability, and aurantiamarin has the brittleness for reducing vasopermeability and capillary wall, reduce blood lipid
And cholesterol effect, therefore, mended in extravasated blood and cirsoid patient caused by because of fragility of blood vessels and permeability increase
Aurantiamarin is filled, the generation of oedema, bleeding and the diseases such as different types of ulcer and extravasated blood can be inhibited；2, anti-inflammatory analgetic, in vitro
Show that aurantiamarin has the function of stronger anti-inflammatory activity and inhibition of pain in vivo studies, it can improve some acute inflammations
Reaction such as inhibits polyblast exudation, and lymphocyte, histocyte and formation of macrophage etc. can also prevent and treat chronic inflammation
As granuloma capilary is formed, blood vessel periphery tumor is formed and the appearance of collagenous fibres；3, to the inhibiting effect of cancer cell, aurantiamarin
There is certain inhibiting effect to human breast cancer cell hyperplasia, Extract from Orange Peel is to human lung carcinoma cell, rectum cancer cell, kidney cancer cell
There is the inhibitory activity of conspicuousness；4, bacteriostasis, in vitro in test, aurantiamarin, hesperetin and other many flavonoids are all
Show to inhibit the effect of plant, the infection of microorganism in animal and proliferation；5, antiultraviolet acts on, recently many research
In terms of the oxidative damage removed free radical function and prevent skin for all concentrating on flavonoids, the photooxidation as caused by ultraviolet radiation
Change the pathogenesis that pressure may be cutaneum carcinoma and light aging；6, in addition to the above effect, orange peel is general also just like relieving pain and bring down a fever, resist
Oxidation adjusts immunity, adjusts hormonal balance, inhibits the effects of ulcer, healing of wound.
Mostly gently aurantiamarin processed, aurantiamarin molecule are irregular nonplanar structure to the aurantiamarin of prior art preparation, are contained
Two phenolic hydroxyl groups of 5-OH and 3 '-OH, extremely fluffy, electrostatic is extremely strong, leads to product packaging transport difficult, and it is quick-fried to be easy to happen dust
It is fried.
Summary of the invention
The present invention provides a kind of preparation method for remaking aurantiamarin and the aurantiamarins being prepared, existing light to solve
The technical issues of bulk density of aurantiamarin processed is low, and electrostatic is strong, fills transport difficult, is easy to happen dust explosion.
The technical solution adopted by the invention is as follows:
A kind of preparation method for remaking aurantiamarin, comprising the following steps: light aurantiamarin processed is impregnated with lye, is expected
Liquid；Feed liquid and lye in step 1) carries out to moment in such a way that pressurization liquidates to be mixed, and mixed liquor is obtained；It will be in step 2)
Mixed liquor be separated by solid-liquid separation, dry, obtain recasting aurantiamarin.
Further, the pressure to liquidate of pressurizeing is 0.5MPa~2MPa.
Further, feed liquid and the volume ratio of lye are 1: 1~3 in step 2).
Further, gently aurantiamarin processed and lye mass ratio are 1~3: 1 in step 1).
Further, the concentration of lye is 0.1%~0.5%；Lye includes sodium hydroxide, potassium hydroxide, ammonium hydroxide or ripe
In lime.
Further, gently the bulk density of aurantiamarin processed is 0.1mg/m~0.3mg/ml；The time impregnated in step (1)
For 0.5h~2h.
Further, be separated by solid-liquid separation in step 3) using flame filter press, tripod pendulum type batch centrifugal, scraper plate centrifuge, settle from
Scheming or belt filter press.
It further, further include cleaning treatment after mixed liquor is separated by solid-liquid separation in step 3), cleaning treatment first uses alcohol
It washes, then using washing.
According to another aspect of the present invention, a kind of aurantiamarin is additionally provided, using the preparation method of above-mentioned recasting aurantiamarin
It is prepared.
Further, the bulk density of aurantiamarin is 0.35mg/m~0.7mg/ml；The purity of aurantiamarin is at least 94%.
The invention has the following advantages:
The preparation method of recasting aurantiamarin of the invention impregnates light aurantiamarin processed with lye, the feed liquid and lye of acquisition
The mode to liquidate of pressurizeing carries out moment mixing, is separated by solid-liquid separation, drying, obtains recasting aurantiamarin.Aurantiamarin crystal impregnates through alkali, is right
After punching, intramolecular-OH can be destroyed and form hydrogen bond or covalent bond, charge is made to disappear, reduce intermolecular repulsion, reduce intermolecular distance
From bulk density becomes larger.Also, feed liquid and lye carries out to moment in such a way that pressurization liquidates to be mixed, on the one hand, by feed liquid
It pressurizes abrupt release, is dispersed into small-molecule substance, can both expose more charges, form hydrogen bond or covalent bond, and can be with
The formation for reducing irregular nonplanar structure forms small crystal structure, so that intermolecular distance reduces, stacked area is reduced；Separately
On the one hand, by feed liquid and lye in such a way that pressurization liquidates, what the new feed liquid ejected touched is all new lye, dense
Degree difference is larger, and mixability is identical, and guarantee forms orderly crystal structure, further increases conversion ratio.Remake aurantiamarin
The recasting aurantiamarin that preparation method obtains, heap density become larger, so that product is easier to transport, reduce packaging and transportation cost, greatly
It is big to reduce dust explosion risk.
Other than objects, features and advantages described above, there are also other objects, features and advantages by the present invention.
Below with reference to accompanying drawings, the present invention is described in further detail.
Detailed description of the invention
The attached drawing constituted part of this application is used to provide further understanding of the present invention, schematic reality of the invention
It applies example and its explanation is used to explain the present invention, do not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 is the preparation method flow chart of the recasting aurantiamarin of the preferred embodiment of the present invention.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
Fig. 1 is the preparation method flow chart of the recasting aurantiamarin of the preferred embodiment of the present invention.
As shown in Figure 1, the preparation method of the recasting aurantiamarin of the present embodiment, comprising the following steps:
S1: light aurantiamarin processed is impregnated with lye, obtains feed liquid；
S2: feed liquid and lye carries out to moment in such a way that pressurization liquidates to be mixed, and mixed liquor is obtained；
S3: mixed liquor is separated by solid-liquid separation, drying, obtains recasting aurantiamarin.
The preparation method of recasting aurantiamarin of the invention impregnates light aurantiamarin processed with lye, the feed liquid and lye of acquisition
The mode to liquidate of pressurizeing carries out moment mixing, is separated by solid-liquid separation, drying, obtains recasting aurantiamarin.Aurantiamarin crystal impregnates through alkali, is right
After punching, intramolecular-OH can be destroyed and form hydrogen bond or covalent bond, charge is made to disappear, reduce intermolecular repulsion, reduce intermolecular distance
From bulk density becomes larger.Also, feed liquid and lye carries out to moment in such a way that pressurization liquidates to be mixed, on the one hand, by feed liquid
It pressurizes abrupt release, is dispersed into small-molecule substance, can both expose more charges, form hydrogen bond or covalent bond, and can be with
The formation for reducing irregular nonplanar structure forms small crystal structure, so that intermolecular distance reduces, stacked area is reduced；Separately
On the one hand, by feed liquid and lye in such a way that pressurization liquidates, what the new feed liquid ejected touched is all new lye, dense
Degree difference is larger, and mixability is identical, and guarantee forms orderly crystal structure, further increases conversion ratio.Remake aurantiamarin
The recasting aurantiamarin that preparation method obtains, heap density become larger, so that product is easier to transport, reduce packaging and transportation cost, greatly
It is big to reduce dust explosion risk.
In the present embodiment, the pressure to liquidate of pressurizeing is 0.5MPa~2MPa.Pressure that above-mentioned pressurization liquidates, at any time pressure
Increase, aurantiamarin compact crystal structure, so that generating void effect, hesperidin crystal molecule during abrupt release pressure
With the collision opportunity of lye, refined so that hesperidin crystal molecule is broken.But when the pressure that pressurization liquidates is more than 2MPa, high pressure
Under the conditions of, equipment loss is high, increases cost, and pressure is higher, and the thermal energy of generation is more, and high temperature is avoided to influence the property of aurantiamarin
Energy.Above-mentioned recasting aurantiamarin is with short production cycle, at low cost, high income, and entire production process economizes on resources, and protects environment.
Above-mentioned pressurization to be punched in moment mixing extractor in carry out, moment mix extractor include tank body, tank body is equipped with:
For being passed through the alkali lye pipeline of lye, alkali lye pipeline carries out pressurized delivered to lye by power device, for being passed through feed liquid simultaneously
The feed liquid pipeline for liquidating and carrying out that moment mixes is formed with the lye of alkali lye pipeline, feed liquid pipeline carries out feed liquid by power device
Pressurized delivered, tank base, which is equipped with, to be exported for the feed liquid in tank to be mixed to the mixture obtained with solvent moment to separation of solid and liquid
The output channel that device is separated.Above-mentioned alkali lye pipeline and feed liquid pipeline are that one group of a formation liquidates.Alkali lye pipeline and
Feed liquid pipeline be it is multiple, multiple alkali lye pipelines and feed liquid pipeline, which correspond, to be laid, that is, is formed multiple groups and liquidated.Above-mentioned alkali liquor pipe
Road and the quantity of feed liquid pipeline setting can be designed according to treating capacity and time, to meet different technique requirements.And
Multiple groups, which liquidate, to be opened simultaneously, can also successively develop from the bottom to top, avoid the mixed effect that liquidates that influences each other.
In the present embodiment, feed liquid and the volume ratio of lye are 1: 1~3 in step 2).Lye dosage is 1~3 times of feed liquid
Amount, room temperature preparation recasting aurantiamarin, does not need consumption steam, and hybrid mode is moment mixing, can operate continuously, i.e., side mixes
While being separated by solid-liquid separation, yield is big, and production capacity is high, and at low cost, the recasting content of hesperidin of acquisition is high by 94~98%.Above-mentioned immersion is light
Aurantiamarin processed and to form slurry be infuser device, above-mentioned for installing lye is lye device, and infuser device passes through feed liquid
Pipeline is connected on moment mixing extractor, and lye device is connected on moment mixing extractor by alkali lye pipeline, the company of being formed
Logical access, conveniently works continuously.Preferably, infuser device uses steeping tank, and lye device uses alkali liquid tank.
In the present embodiment, gently aurantiamarin processed and lye mass ratio are 1~3: 1 in step 1).Light aurantiamarin processed and lye are mixed
Sufficiently dissolution is closed, in lye, aurantiamarin open loop dissolution destroys hydrogen bond or covalent bond that aurantiamarin intramolecular-OH is formed, makes electricity
Lotus disappears, and reduces intermolecular repulsion, reduces intermolecular distance, and heap density becomes larger.But this stage, it is only capable of destroying light orange peel processed
The charge on glycosides surface, intramolecule structure are not destroyed, cause heap density to become larger unobvious, also, conversion ratio is relatively low.
In the present embodiment, the concentration of lye is 0.1%~0.5%.Lye include sodium hydroxide, potassium hydroxide, ammonium hydroxide or
White lime.Above-mentioned, the concentration of lye is 0.1%~0.5%, when the concentration is too high, although aurantiamarin is in the alkali of high energy concentration
It is easy dissolution, but loss is more, subsequent operation process is more complex.Above-mentioned lye uses low-concentration alkali liquor, is conducive to destroy and divide
The hydrogen bond or covalent bond that-OH in son is formed.
In the present embodiment, gently the bulk density of aurantiamarin processed is 0.1mg/m~0.3mg/ml.The time impregnated in step 1)
For 0.5h~2h.The bulk density of above-mentioned light aurantiamarin processed is 0.1mg/m~0.3mg/ml, and gently aurantiamarin molecule processed is irregular
Nonplanar structure, containing two phenolic hydroxyl groups of 5-OH and 3 '-OH, 5-OH and 4-C=O can form intramolecular covalent bonds or hydrogen bond, produce
Raw electronics opposite direction carbonyl offset, and it is in electropositive；3 '-OH and 4 '-OCH3Also intramolecular covalent bonds or hydrogen bond can be formed, thus band
Positive electricity.Therefore it is easy to form electrostatic in polybag in the aurantiamarin of dry high-purity, be adsorbed on polybag.Simultaneously smaller
Like charges in particle between molecule repel, so that intermolecular distance is big, and heap density is smaller.Aurantiamarin molecule it is irregular non-
Planar structure may make molecule that can not form orderly crystal structure.Crystal structure at random, so that intermolecular distance is big, and heap
Density is smaller.Aurantiamarin has multiple hydroxyls between molecule and molecule, is likely to form irregular chain in intermolecular hydrogen bonding, may
Gap is larger between chain crystal, and heap density is smaller.Light aurantiamarin processed is extremely fluffy, and electrostatic is extremely strong, and product packaging is caused to be transported
Defeated difficulty, and it is easy to happen dust explosion.Gently aurantiamarin processed and be uniformly mixed with dipping by lye, the time of immersion be 0.5h~
2h destroys hydrogen bond or covalent bond and the be uniformly mixed that-OH of intramolecular is formed.Light aurantiamarin processed becomes after remaking aurantiamarin, point
Arrangement between son changes, and heap density is caused to be changed, and guarantee forms orderly crystal structure.
It is separated by solid-liquid separation in the present embodiment, in step 3) using flame filter press, tripod pendulum type batch centrifugal, scraper plate centrifuge, sedimentation
Centrifuge or belt filter press.The mixed liquor that feed liquid and lye moment are mixed to form directly is discharged from output channel, into solid-liquid
It is separated by solid-liquid separation in separator, the crystal of acquisition is further processed again.
It further include cleaning treatment after mixed liquor is separated by solid-liquid separation in step 3) in the present embodiment, cleaning treatment first uses
Alcohol is washed, then using washing.Specifically, aurantiamarin crystal is separated by solid-liquid separation using flame filter press, first carries out ethyl alcohol cleaning,
Impurity is removed, then is cleaned using pure water, is pressed dry, the crystal pressed dry is dry, and drying can be dry by pulse Vacuum, obtains miscellaneous
Matter content is low, and the recasting aurantiamarin crystal of high-purity, product content is up to 94%~98%.It is above-mentioned to press dry using plate and frame filter press
It is squeezed with hydraulic pressure.
According to another aspect of the present invention, a kind of aurantiamarin is additionally provided, using the preparation method of above-mentioned recasting aurantiamarin
It is prepared.The orange peel glycoside product that the preparation method of above-mentioned recasting aurantiamarin is prepared is high with content, density is big, quality is steady
Fixed advantage, market value with higher.
In the present embodiment, the bulk density of aurantiamarin is 0.35mg/m~0.7mg/ml.The purity of aurantiamarin is at least
94%.The bulk density of aurantiamarin is 0.35mg/m~0.7mg/ml.Heap density is big, so that the product of preparation is easier to transport,
Packaging and transportation cost are reduced, dust explosion risk is substantially reduced.
Embodiment
Reagent is commercially available in following embodiment
Embodiment 1
By 5kg, gently aurantiamarin processed is added to steeping tank, and the soaking with sodium hydroxide 1h for being 0.1% with the mass fraction of 5L is obtained
Feed liquid is obtained, the sodium hydroxide that the mass fraction of 10L is 0.1% is added in alkali liquid tank, the feed liquid pipeline of steeping tank is connected to mixing
In tank, feed liquid pipeline is equipped with valve and pressure pump, and the alkali lye pipeline of alkali liquid tank is connected in blending tank, and alkali lye pipeline is equipped with
Valve and pressure pump, the feed liquid pipeline of steeping tank and the alkali lye pipeline of alkali liquid tank are distributed in moment blending tank two sides and opposite cloth
If adjusting two pressure pumps is 1.5MPa, while opening two valves, feed liquid and lye formation are liquidated, moment completes mixing,
Be pumped into flame filter press and be separated by solid-liquid separation by centrifugation again, then cleaned using 5L80% ethyl alcohol, 5L purified water into
Row cleaning, press dry, and carries out pulse Vacuum drying to crystal, obtains recasting aurantiamarin.
Embodiment 2
By 50kg, gently aurantiamarin processed is added to steeping tank, impregnates 2h with the ammonium hydroxide that the mass fraction of 50L is 0.1%, obtains
The ammonium hydroxide that the mass fraction of 100L is 0.1% is added in alkali liquid tank for feed liquid, and the feed liquid pipeline of steeping tank is connected in blending tank,
Feed liquid pipeline is equipped with valve and pressure pump, and the alkali lye pipeline of alkali liquid tank is connected in blending tank, and alkali lye pipeline is equipped with valve
And pressure pump, the feed liquid pipeline of steeping tank and the alkali lye pipeline of alkali liquid tank are distributed in moment blending tank two sides and opposite laying, adjust
Saving two pressure pumps is 1MPa, while opening two valves, feed liquid and lye formation is liquidated, moment completes mixing, then passes through
Centrifugation, which is pumped into flame filter press, to be separated by solid-liquid separation, then is cleaned using 50L80% ethyl alcohol, and 50L purified water carries out clear
It washes, press dry, pulse Vacuum drying is carried out to crystal, obtains recasting aurantiamarin.
Embodiment 3
By 10kg, gently aurantiamarin processed is added to steeping tank, impregnates 1.5h with the white lime that the mass fraction of 20L is 0.5%,
Feed liquid is obtained, the ammonium hydroxide that the mass fraction of 20L is 0.1% is added in alkali liquid tank, the feed liquid pipeline of steeping tank is connected to blending tank
Interior, feed liquid pipeline is equipped with valve and pressure pump, and the alkali lye pipeline of alkali liquid tank is connected in blending tank, and alkali lye pipeline is equipped with valve
Door and pressure pump, the feed liquid pipeline of steeping tank and the alkali lye pipeline of alkali liquid tank are distributed in moment blending tank two sides and opposite laying,
Adjusting two pressure pumps is 1.5MPa, while opening two valves, and feed liquid and lye formation are liquidated, and moment completes mixing, then
Be pumped into belt filter press and be separated by solid-liquid separation by centrifugation, then cleaned using 20L80% ethyl alcohol, 20L purified water into
Row cleaning, press dry, and carries out pulse Vacuum drying to crystal, obtains recasting aurantiamarin.
Comparative example 1
By 5kg, gently aurantiamarin processed is added to steeping tank, the soaking with sodium hydroxide 4h for being 0.1% with the mass fraction of 10L, then
It is pumped into flame filter press and is separated by solid-liquid separation by centrifugation, then cleaned using 5L80% ethyl alcohol, 5L purified water carries out
Cleaning, press dry, and carries out pulse Vacuum drying to crystal, obtains recasting aurantiamarin.
Comparative example 2
By 5kg, gently aurantiamarin processed is added to steeping tank, and the soaking with sodium hydroxide 1h for being 0.1% with the mass fraction of 10L is obtained
Feed liquid is obtained, the sodium hydroxide that the mass fraction of 10L is 0.1% is added in alkali liquid tank, the feed liquid pipeline of steeping tank is connected to mixing
In tank, feed liquid pipeline is equipped with valve, and the alkali lye pipeline of alkali liquid tank is connected in blending tank, and alkali lye pipeline is equipped with valve, leaching
The alkali lye pipeline of the feed liquid pipeline and alkali liquid tank that steep tank is distributed in blending tank two sides and opposite laying, while opening two valves,
Feed liquid is mixed with lye, then is pumped into flame filter press and is separated by solid-liquid separation by centrifugation, then using 5L80% ethyl alcohol into
Row cleaning, 5L purified water are cleaned, are pressed dry, and are carried out pulse Vacuum drying to crystal, are obtained recasting aurantiamarin.
By above-described embodiment 1, embodiment 2 and embodiment 3, comparative example 1 and comparative example 2 are detected, testing result such as table 1
It is shown.
1 aurantiamarin quality measurements of table
Recasting aurantiamarin bulk density and purity in above-described embodiment 1,2 and 3 all obviously increase, and changing effect is good, and
And the bulk density of light aurantiamarin processed is smaller, what the bulk density of the recasting aurantiamarin of acquisition increased is more obvious.Comparative example 1 and 2
Recasting aurantiamarin bulk density increase it is smaller, purity does not also increase significantly.The heap for the aurantiamarin that above-described embodiment obtains
Product density is greater than 0.4mg/m, and the purity of aurantiamarin is greater than 94%, that is, improves the content of aurantiamarin, effectively reduce packaging and
The cost of transport reduces the danger of dust explosion.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of preparation method for remaking aurantiamarin, which comprises the following steps:
1) light aurantiamarin processed is impregnated with lye, obtains feed liquid；
2) feed liquid and the lye in the step 1) carries out to moment in such a way that pressurization liquidates to be mixed, and mixed liquor is obtained；
3) mixed liquor in the step 2) is separated by solid-liquid separation, dries, obtains the recasting aurantiamarin.
2. the preparation method of recasting aurantiamarin according to claim 1, which is characterized in that
The pressure to liquidate of pressurizeing is 0.5MPa~2MPa.
3. the preparation method of recasting aurantiamarin according to claim 1, which is characterized in that
Feed liquid and the volume ratio of the lye are 1: 1~3 in the step 2).
4. the preparation method of recasting aurantiamarin according to claim 1, which is characterized in that
Gently aurantiamarin processed and the lye mass ratio are 1~3: 1 in the step 1).
5. the preparation method of recasting aurantiamarin according to claim 1, which is characterized in that
The mass concentration of the lye is 0.1%~0.5%；
The lye includes sodium hydroxide, potassium hydroxide, ammonium hydroxide or white lime.
6. the preparation method of recasting aurantiamarin according to claim 1, which is characterized in that
The bulk density of the light aurantiamarin processed is 0.1mg/m~0.3mg/ml；
The time impregnated in the step 1) is 0.5h~2h.
7. the preparation method of recasting aurantiamarin according to any one of claims 1 to 6, which is characterized in that
It is separated by solid-liquid separation in the step 3) and uses flame filter press, tripod pendulum type batch centrifugal, scraper plate centrifuge, sedimentation centrifuge or belt
Filter press.
8. the preparation method of recasting aurantiamarin according to any one of claims 1 to 6, which is characterized in that
It further include cleaning treatment after mixed liquor is separated by solid-liquid separation in the step 3), the cleaning treatment is first washed using alcohol, then
Using washing.
9. a kind of aurantiamarin, which is characterized in that using the preparation method of the described in any item recasting aurantiamarins of claim 1 to 8
It is prepared.
10. aurantiamarin according to claim 9, which is characterized in that
The bulk density of the aurantiamarin is 0.35mg/m~0.7mg/ml；
The purity of the aurantiamarin is at least 94%.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119411A (en) * | 2014-08-12 | 2014-10-29 | 四川天予植物药业有限公司 | Method for preparing high-purity hesperidin |
| CN105399787A (en) * | 2015-12-08 | 2016-03-16 | 桂林三宝药业有限公司 | Method for extracting hesperidin, neohesperidin and synephrine from citrus peel and citrus fruits |
| CN108299520A (en) * | 2018-05-03 | 2018-07-20 | 中南民族大学 | Promote the method and aurantiamarin of extraction aurantiamarin purity |
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2019
- 2019-02-25 CN CN201910137553.4A patent/CN109796507B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119411A (en) * | 2014-08-12 | 2014-10-29 | 四川天予植物药业有限公司 | Method for preparing high-purity hesperidin |
| CN105399787A (en) * | 2015-12-08 | 2016-03-16 | 桂林三宝药业有限公司 | Method for extracting hesperidin, neohesperidin and synephrine from citrus peel and citrus fruits |
| CN108299520A (en) * | 2018-05-03 | 2018-07-20 | 中南民族大学 | Promote the method and aurantiamarin of extraction aurantiamarin purity |
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Denomination of invention: Preparation method of reconstituted hesperidin and prepared hesperidin Effective date of registration: 20220822 Granted publication date: 20201225 Pledgee: Bank of China Limited Lianyuan Sub-branch Pledgor: LIANYUAN KANGBIOTECH CO.,LTD. Registration number: Y2022980013215 |