CN109789416B - 用于检测样品的分析装置及方法 - Google Patents

用于检测样品的分析装置及方法 Download PDF

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Publication number
CN109789416B
CN109789416B CN201780061317.8A CN201780061317A CN109789416B CN 109789416 B CN109789416 B CN 109789416B CN 201780061317 A CN201780061317 A CN 201780061317A CN 109789416 B CN109789416 B CN 109789416B
Authority
CN
China
Prior art keywords
cartridge
analysis device
membrane
valve
actuator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201780061317.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN109789416A (zh
Inventor
R·温特
U·安伯格
G·布鲁克曼
A·尼迈耶
A·奥斯特加特
H·保尔斯
H·史摩克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of CN109789416A publication Critical patent/CN109789416A/zh
Application granted granted Critical
Publication of CN109789416B publication Critical patent/CN109789416B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micromachines (AREA)
  • Fluid-Driven Valves (AREA)
CN201780061317.8A 2016-10-07 2017-10-05 用于检测样品的分析装置及方法 Expired - Fee Related CN109789416B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16020380.8 2016-10-07
EP16020380 2016-10-07
PCT/EP2017/025288 WO2018065111A1 (en) 2016-10-07 2017-10-05 Analysis device and method for testing a sample

Publications (2)

Publication Number Publication Date
CN109789416A CN109789416A (zh) 2019-05-21
CN109789416B true CN109789416B (zh) 2022-06-21

Family

ID=57132961

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780061317.8A Expired - Fee Related CN109789416B (zh) 2016-10-07 2017-10-05 用于检测样品的分析装置及方法

Country Status (8)

Country Link
US (2) US11071981B2 (ko)
EP (1) EP3523036A1 (ko)
JP (2) JP6999661B2 (ko)
KR (1) KR20190066038A (ko)
CN (1) CN109789416B (ko)
BR (1) BR112019006840A2 (ko)
CA (1) CA3037216A1 (ko)
WO (1) WO2018065111A1 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142781A (en) * 1989-08-11 1992-09-01 Robert Bosch Gmbh Method of making a microvalve
CN105873681A (zh) * 2013-11-18 2016-08-17 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
CN105980058A (zh) * 2014-01-07 2016-09-28 达克雷诊断器材有限公司 流体输送装置、系统和方法

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JPS6469783A (en) * 1987-09-10 1989-03-15 Mitsubishi Chem Ind Pneumatically driven diaphragm pump
US5096669A (en) 1988-09-15 1992-03-17 I-Stat Corporation Disposable sensing device for real time fluid analysis
US6394417B1 (en) * 1998-10-09 2002-05-28 Swagelok Co. Sanitary diaphragm valve
US20020042140A1 (en) 1999-03-03 2002-04-11 Alfred Hagemeyer Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
US6742544B2 (en) * 2001-03-07 2004-06-01 Symyx Technologies, Inc. Injection valve array
US7192001B2 (en) 2003-05-08 2007-03-20 The Regents Of The University Of Michigan Office Of Technology Transfer Thermopneumatic microvalve
CN101218032A (zh) 2005-05-25 2008-07-09 西门子公司 综合和自动化的dna或蛋白质分析系统及其运行方法
FR2913524B1 (fr) * 2007-03-05 2009-04-17 Itt Mfg Enterprises Inc Commutateur electrique a effort de rappel variable.
WO2010088514A1 (en) 2009-01-30 2010-08-05 Micronics, Inc. Portable high gain fluorescence detection system
EP2249142A1 (en) * 2009-05-06 2010-11-10 Poulten Selfe & Lee Ltd. A viscometer and a method for operating the same
DE102009023430B4 (de) 2009-05-29 2013-07-25 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Steuern von Fluidströmen in Lab-on-a-Chip-Systemen sowie Verfahren zum Herstellen der Vorrichtung
US8747776B2 (en) * 2009-10-27 2014-06-10 The Regents Of The University Of Michigan Microfluidic platform for discrete cell assay
ES2798099T3 (es) * 2010-03-09 2020-12-09 Ande Corp Biochip unitario que proporciona un procesamiento desde la inserción de muestras hasta la obtención de resultados y métodos de fabricación
CN102178605B (zh) * 2011-03-09 2014-03-26 天津大学 具有自动检测功能的中药巴布剂成型设备
US20150136604A1 (en) * 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
FR2993572B1 (fr) * 2012-07-23 2016-04-15 Emd Millipore Corp Circuit pour liquide biologique comportant une vanne a pincement
JP5898635B2 (ja) * 2013-02-25 2016-04-06 株式会社日立ハイテクノロジーズ 核酸分析カートリッジの製造方法
GB2516671A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which actuates and latches
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
CN106461697B (zh) 2014-03-13 2019-05-14 吉纳帕希斯股份有限公司 用于样品制备和分析的微流体装置、系统和方法
US10525466B2 (en) * 2016-09-16 2020-01-07 General Electric Company Compact valve array with actuation system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142781A (en) * 1989-08-11 1992-09-01 Robert Bosch Gmbh Method of making a microvalve
CN105873681A (zh) * 2013-11-18 2016-08-17 尹特根埃克斯有限公司 用于样本分析的卡盒和仪器
CN105980058A (zh) * 2014-01-07 2016-09-28 达克雷诊断器材有限公司 流体输送装置、系统和方法

Also Published As

Publication number Publication date
JP6999661B2 (ja) 2022-01-18
KR20190066038A (ko) 2019-06-12
CN109789416A (zh) 2019-05-21
BR112019006840A2 (pt) 2019-06-25
WO2018065111A1 (en) 2018-04-12
US20180099281A1 (en) 2018-04-12
EP3523036A1 (en) 2019-08-14
JP2022058388A (ja) 2022-04-12
CA3037216A1 (en) 2018-04-12
JP2019529939A (ja) 2019-10-17
US11071981B2 (en) 2021-07-27
US20210268502A1 (en) 2021-09-02

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Granted publication date: 20220621