CN109789094A - κ-阿片类受体激动剂的持续释放组合物 - Google Patents

κ-阿片类受体激动剂的持续释放组合物 Download PDF

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Publication number
CN109789094A
CN109789094A CN201780045316.4A CN201780045316A CN109789094A CN 109789094 A CN109789094 A CN 109789094A CN 201780045316 A CN201780045316 A CN 201780045316A CN 109789094 A CN109789094 A CN 109789094A
Authority
CN
China
Prior art keywords
substituted
release composition
pain
sustained release
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780045316.4A
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English (en)
Chinese (zh)
Inventor
高塔姆·加特内卡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Titan Pharmaceuticals Inc
Original Assignee
Jt Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jt Pharmaceutical Co filed Critical Jt Pharmaceutical Co
Publication of CN109789094A publication Critical patent/CN109789094A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201780045316.4A 2016-06-03 2017-06-05 κ-阿片类受体激动剂的持续释放组合物 Pending CN109789094A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345583P 2016-06-03 2016-06-03
US62/345,583 2016-06-03
PCT/US2017/035874 WO2017210668A1 (en) 2016-06-03 2017-06-05 Sustained release compositions of kappa-opioid receptor agonist

Publications (1)

Publication Number Publication Date
CN109789094A true CN109789094A (zh) 2019-05-21

Family

ID=60478002

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780045316.4A Pending CN109789094A (zh) 2016-06-03 2017-06-05 κ-阿片类受体激动剂的持续释放组合物

Country Status (5)

Country Link
US (1) US20200316159A1 (https=)
EP (1) EP3463306A4 (https=)
JP (1) JP2019517586A (https=)
CN (1) CN109789094A (https=)
WO (1) WO2017210668A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114873741A (zh) * 2022-05-31 2022-08-09 南京大学 一种脱氮缓释碳源材料及其制备方法和应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US12215173B2 (en) 2019-08-07 2025-02-04 HUMANWELL PHARMACEUTICAL US, Inc. Kappa opioid receptor peptide amide ligands
CA3171225A1 (en) * 2020-03-18 2021-09-23 Bryan R. Wilson Oligosaccharide formulations of kappa opioid receptor agonists
KR20230024419A (ko) 2020-06-25 2023-02-20 휴먼웰 파마슈티컬 유에스 의학적 장애 치료용 펩티드
MX2023012087A (es) * 2021-04-14 2024-02-27 Titan Pharmaceuticals Inc Implantes de agonistas de los receptores kappa-opioides para tratamiento del prurito.
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140171457A1 (en) * 2002-05-31 2014-06-19 Titan Pharmaceuticals, Inc. Implantable Polymeric Device for Sustained Release of Buprenorphine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2653072A1 (en) * 2006-05-26 2007-12-06 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
MX2009005000A (es) * 2006-11-10 2009-10-12 Cara Therapeutics Inc Amidas de peptidos sinteticos.
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2008131508A1 (en) * 2007-05-01 2008-11-06 Fundação De Amparo À Pesquisa Do Estado De São Paulo - Fapesp Analgesic compounds
TWI501788B (zh) * 2010-09-02 2015-10-01 含陰離子聚合物之抗破碎劑型
EP2928562A4 (en) * 2012-12-06 2016-06-22 Stealth Peptides Int Inc PEPTIDE THERAPEUTIC PRODUCTS AND METHODS OF USE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140171457A1 (en) * 2002-05-31 2014-06-19 Titan Pharmaceuticals, Inc. Implantable Polymeric Device for Sustained Release of Buprenorphine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FRANCIS M.HUGHES ET AL.: "Development of a Peptide-Derived Orally-Active Kappa-Opioid Receptor Agonist Targeting Peripheral Pain", 《THE OPEN MEDICINAL CHEMISTRY JOURNAL》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114873741A (zh) * 2022-05-31 2022-08-09 南京大学 一种脱氮缓释碳源材料及其制备方法和应用

Also Published As

Publication number Publication date
EP3463306A1 (en) 2019-04-10
WO2017210668A1 (en) 2017-12-07
US20200316159A1 (en) 2020-10-08
EP3463306A4 (en) 2020-03-11
JP2019517586A (ja) 2019-06-24

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Legal Events

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PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20210531

Address after: California, USA

Applicant after: TITAN PHARMACEUTICALS, Inc.

Address before: south carolina

Applicant before: JT Pharmaceuticals, Inc.

TA01 Transfer of patent application right
RJ01 Rejection of invention patent application after publication

Application publication date: 20190521

RJ01 Rejection of invention patent application after publication