CN109771635A - A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition - Google Patents
A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition Download PDFInfo
- Publication number
- CN109771635A CN109771635A CN201711110311.3A CN201711110311A CN109771635A CN 109771635 A CN109771635 A CN 109771635A CN 201711110311 A CN201711110311 A CN 201711110311A CN 109771635 A CN109771635 A CN 109771635A
- Authority
- CN
- China
- Prior art keywords
- radix glycyrrhizae
- oligosaccharide
- glucose
- acidi lactici
- bacillus acidi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition is technical field of pharmaceuticals.Radix Glycyrrhizae ribosome inactivating protein is used to prepare to the drug for increasing Bacillus acidi lactici quantity in woman vagina as active component.Composition is with Radix Glycyrrhizae ribosome inactivating protein, mannosan, oligosaccharide or/and glucose, Bletilla glucomannan, or being further added by Radix Codonopsis, barberry and Rhizoma Atractylodis Macrocephalae extract is active component, relative weight share are as follows: 0.5~1.0 part of Radix Glycyrrhizae ribosome inactivating protein, 1.5~3.0 parts of mannosan, oligosaccharide or/and 0.2~2.0 part of glucose, 0.2~0.5 part of Bletilla glucomannan, one of Radix Codonopsis dry powder, barberry dry powder and Rhizoma Atractylodis Macrocephalae dry powder or more than one totally 1.0~3.0 parts of resulting extracts.It can be water-soluble complex liquid, wherein preferably gelling agent;It is also possible to the pharmaceutical dosage form that solid dosage forms such as suppository, disintegrated tablet etc. is suitable for external application.Compared to the prior art, products obtained therefrom does not need to save at low temperature, and the resting period is long, easy to use.
Description
Technical field
The present invention is technical field of pharmaceuticals.
Background technique
The micropopulation for parasitizing healthy women intravaginal mainly has bacterium, fungi, protozoon and virus.They mainly dwell
The mucous membrane gauffer of vagina and fornix portion, followed by uterine neck.The main permanent bacterium of intravaginal has Bacillus acidi lactici, epidermis grape ball
Bacterium, Escherichia coli, corynebacteria, B race streptococcus, streptococcus fecalis, mycoplasma, Candida albicans, peptococcus and bacteroid etc.
Deng.Mutually restriction, mutually coordinated, dynamic yin are constituted between a variety of microflora groups of intravaginal and host, environment
Road microecological balance.The microecological balance of vagina plays an important role to the self purification and the healthy of host that maintain it.When
Sharply decline of the host due to using broad-spectrum antibiotic, ovarian function, vagina caused by the factors such as surgical operation, external force and childbirth
Damage, radioactive ray and immunosuppressor the reasons such as excessively use, cause the habitat of vagina that change dramatically occurs, can destroy it
Microecological balance leads to the flora imbalance of vagina.Easily cause the infectious diseases of vagina at this time, the main source of infection is yin
Conditioned pathogen in road Tiny ecosystem group, such as Escherichia coli, bacteroid, peptococcus, staphylococcus aureus, B race hammer
Bacterium, Candida albicans, trichomonad and mycoplasma etc..Vaginal dysbacteriosis is mainly shown as various types of vaginitis.
Antibiotic, metronidazole, estrogen and acidification vagina are mainly used for the remedy measures of such disease at present
Preparation kill the pathogenic microorganism of intravaginal, but effect is undesirable.
Generally measuring viable count in healthy women vaginal discharge with qualitative and quantitative method is 102-9/ml, anaerobic bacteria
Ratio with aerobic bacteria is 5: 1.Wherein Bacillus acidi lactici is the permanent bacterium of most important, quantity at most in vagina normal flora, number
Amount accounts for 95% or more, up to 8 × 107/ml.Bacillus acidi lactici plays an important role in maintaining microecology in vaginas balance, it is decomposable
The intracellular glycogen of vaginal mucosal epithelium, generates a certain amount of lactic acid, so that vagina is kept acidic environment, is conducive to the self-cleaning of vagina
Effect.The immune function of body can be improved in it simultaneously, and activating macrophage maintains the anti-infection ability of vagina part.Furthermore it
Also have the function of preventing cervicovaginal epithelial metaplasia.(Wang Lisheng, Pan Lingjia, Zhou Dianyuan China microecology magazine .1998,
10 (5): 300-302.).Using probiotics made of the Bacillus acidi lactici in vagina normal microflora to this kind of illness
Prophylactic treatment and health care achieve preferable effect.Currently, there are many using system made of Bacillus acidi lactici on domestic and international market
Agent is as determined monarch's life, lactic acid bacteria capsule etc..But since viable bacteria body needs to save at low temperature, the resting period is short, for practical application
Inconvenience, especially out of town trip etc..
Application No. is 2011101840614 Chinese patent documents to disclose " a kind of human body external compound preparation and its use
On the way ", first invention people i.e. the first invention people of present patent application.The compound preparation is with phytolectin (PHA) and sweet
Dew glycan is active component, plays contraception, prevention and treatment sexually transmitted disease and lubrication, and effect is not to increase in woman vagina
Bacillus acidi lactici quantity maintains microecological balance.
Summary of the invention
The purpose of the present invention: providing a kind of preparation method for adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition,
Main function is Bacillus acidi lactici quantity in increase woman vagina, maintains microecological balance, and product does not need to save at low temperature,
Resting period is long, easy to use.
Purposes invention, which is characterized in that for Radix Glycyrrhizae ribosome inactivating protein being used to prepare as active component, increases women's yin
The drug of Bacillus acidi lactici quantity in road.And the weight content of Radix Glycyrrhizae ribosome inactivating protein is preferably thousand points of medicine gross weight
One of.
Pharmaceutical composition of the present invention is with Radix Glycyrrhizae ribosome inactivating protein, mannosan, oligosaccharide or/and glucose, white
Splendid achnatherum glue is active component, the relative weight share in composition between contained above-mentioned active component are as follows: Radix Glycyrrhizae RIP activity egg
White 0.5~1.0 part, 1.5~3.0 parts of mannosan, oligosaccharide or/and 0.2~2.0 part of glucose, 0.2~0.5 part of Bletilla glucomannan;
Either with Radix Glycyrrhizae ribosome inactivating protein, mannosan, oligosaccharide or/and glucose, Bletilla glucomannan, Radix Codonopsis extract, three
Needle extract, Rhizoma Atractylodis Macrocephalae extract are active component, the relative weight share in composition between contained above-mentioned active component are as follows: sweet
0.5~1.0 part of careless ribosome inactivating protein, 1.5~3.0 parts of mannosan, oligosaccharide or/and 0.2~2.0 part of glucose are white
0.2~0.5 part of splendid achnatherum glue, one of Radix Codonopsis dry powder, barberry dry powder and Rhizoma Atractylodis Macrocephalae dry powder or more than one totally 1.0~3.0 parts of institutes
The extract obtained.Described Radix Glycyrrhizae ribosome inactivating protein can be white Radix Glycyrrhizae ribosome inactivating protein, be also possible to Radix Glycyrrhizae
Ribosome inactivating protein.
Described Radix Codonopsis, barberry and the resulting extract of Rhizoma Atractylodis Macrocephalae dry powder are preferably the extract that water extraction generates, in these
Medicine plant extracts is all made of medium temperature extraction method at the extraction, i.e., temperature is maintained always between 40~60 DEG C in extraction process.
The dosage form of natural drug composition of the present invention can be water-soluble complex liquid, wherein preferably gelling agent;It can also
To be the pharmaceutical dosage form suitable for external application such as solid dosage forms such as suppository, disintegrated tablet.
Natural drug composition of the present invention is mainly used for increasing Bacillus acidi lactici quantity in woman vagina, but can also be used for human body
The prevention and treatment of other illness, such as the treatment of wound.
Natural drug composition coagulant liquid of the present invention is characterized in that in 100ml coagulant liquid containing following component:
0.5~1.0 gram of Radix Glycyrrhizae ribosome inactivating protein,
1.5~3.0 grams of mannosan,
Oligosaccharide or/and 0.5~2.0 gram of glucose,
0.2~0.5 gram of Bletilla glucomannan,
NaCl0.8~0.9 gram,
PH buffer is pharmaceutically coagulant liquid acceptable amount,
Stabilizer is pharmaceutically coagulant liquid acceptable amount,
Preservative is pharmaceutically coagulant liquid acceptable amount;
Either contain following component in 100ml coagulant liquid:
0.5~1.0 gram of Radix Glycyrrhizae ribosome inactivating protein,
1.5~3.0 grams of mannosan,
Oligosaccharide or/and 0.5~2.0 gram of glucose,
0.2~0.5 gram of Bletilla glucomannan,
One of Radix Codonopsis dry powder, barberry dry powder and Rhizoma Atractylodis Macrocephalae dry powder or more than one totally 1.0~3.0 grams of resulting water mention
Object is taken,
NaCl0.8~0.9 gram,
PH buffer is pharmaceutically coagulant liquid acceptable amount,
Stabilizer is pharmaceutically coagulant liquid acceptable amount,
Preservative is pharmaceutically coagulant liquid acceptable amount.
Described Radix Glycyrrhizae ribosome inactivating protein can be white Radix Glycyrrhizae ribosome inactivating protein, be also possible to Radix Glycyrrhizae ribose
Body inactivating protein.
Medicaments compound is the pathological state for body, emphasizes organic cooperation of each component and dosage, carries out multiple location,
Multiple target point, the structure adjusting of multipath, to restore the equilibrium state of body.
Natural drug composition emphasis of the present invention is directed to the Bacillus acidi lactici in close relations with women's health, divides using from Radix Glycyrrhizae
Radix Glycyrrhizae ribosome inactivating protein and oligosaccharide (oligosaccharide or/and glucose) from extraction are key component, are added with other from day
The effective ingredient extracted in right product or Chinese herbal medicine, preparing to become has promotion Vaginal lactobacilli growth, inhibits and killing has
Evil microorganism includes bacterium, the preparation of fungi and virus and other effects, and supplements natural estrogen, prevents from infecting, repairs wound, most
The nature restored based on Bacillus acidi lactici is realized eventually.Prove the product to BV (bacterial vaginosis BV), VVC through practical application
(vulvovaginal candidiasis), BP (bowenoid papulosis), HPV (human papilloma virus) and inhibition of HIV all have inhibition
With killing function.Product of the present invention, which is removed, optionally promotes one or more of beneficial bacterial metabolics containing oligosaccharide and glucose etc.
With breeding, into except the component of host health, also contain phytolectin, they have Bacillus acidi lactici and Bifidobacterium breeding
Apparent facilitation.Therefore, product of the present invention is a kind of novel, while carrying probiotics " grain ", oligosaccharide and breeding
The compound formulation of the PHA of (division) promotor, function and effect are more much more obvious than individual prebiotics.
Oligosaccharide (oligosaccharide or/and glucose) and Bletilla glucomannan are added, the purpose is to enhance repairing for natural drug composition
Reactivation power and the ability for combining skin and mucous membrane;In addition, Bletilla glucomannan itself also has certain bacteriostasis.
Natural drug composition coagulant liquid of the present invention can use in this way: under normal circumstances, with without Radix Codonopsis, barberry and
The coagulant liquid (abbreviation coagulant liquid A) plus water of Rhizoma Atractylodis Macrocephalae ingredient make daily cleaning nursing;Occur first using coagulant liquid A when illness, works as disease
Without the gel containing Radix Codonopsis, barberry and Rhizoma Atractylodis Macrocephalae ingredient usable when mitigating when shape is heavier or using symptom after coagulant liquid A 48h
Liquid (abbreviation coagulant liquid B).White Radix Glycyrrhizae used or Radix Glycyrrhizae ribosome inactivating protein are special in following experiment and embodiment
Sharp applicant laboratory produces in white Radix Glycyrrhizae and Radix Glycyrrhizae from Yunnan extracts.
The principle that product of the present invention Tiny ecosystem maintained and increased Bacillus acidi lactici quantity is:
1. the pH of solution is 4.0~4.5, there is inhibiting effect to most of microorganisms for causing BV, and this pH value is suitble to
The growth of Bacillus acidi lactici;
2. phytolectin is a kind of mitogen, it has been found that Radix Glycyrrhizae ribosome inactivating protein is dense in above-mentioned formula
It can promote lactobacillus growth under degree;
3. also containing oligosaccharide (oligosaccharide and glucose) in solution, in this way, right as the nutriment of Bacillus acidi lactici
Bacillus acidi lactici plays the role of nutritional support;
4. also containing estrogen licoisoflavanone in Radix Glycyrrhizae ribosome inactivating protein extracting solution, related research both domestic and external is aobvious
Show, senile vaginitis patients can reverse the atrophy of vaginal wall to change and alleviate symptom using estrogen, the supplement of estrogen
The thickness of vagina epithelium, the elasticity of vaginal wall are increased, vaginal pH is reduced, has restored the self purification of vagina;
5. phytolectin can stimulate lymphocyte to generate interferon and interleukins.
Beneficial effects of the present invention: compared to the prior art, products obtained therefrom does not need to save at low temperature, the resting period
It is long, it is easy to use.
Specific embodiment
Embodiment
Add barberry again on the basis of being formulated A, the extract of Radix Codonopsis or Rhizoma Atractylodis Macrocephalae etc. becomes formula B.Be formulated B be
Contain in 100 milliliters of coagulant liquids:
0.5 gram of phytolectin,
2.0 grams of mannosan,
Oligosaccharide (total amount of oligosaccharide and glucose) 0.5g,
0.2 gram of Bletilla glucomannan,
Radix Codonopsis dry powder, barberry dry powder and each 1.0 grams of Rhizoma Atractylodis Macrocephalae dry powder, totally 3.0 grams of resulting water extracts, NaCl 0.85
Gram,
PH buffer: citric acid-disodium hydrogen phosphate buffer (pH4.0).Solution A: citric acid 21g or anhydrous citric acid are taken
19.2g adds water to make to be dissolved into 1000ml, sets in refrigerator and saves.Second liquid: taking disodium hydrogen phosphate 71.63g, and water is added to make to be dissolved into
1000ml. takes above-mentioned solution A 61.45ml to mix with second liquid 38.55ml, shake up to get,
Stabilizer: 3.0 grams of mannose,
Preservative: 0.15 gram of ethyl ester sodium,
PH value is 4.5-4.7.
Claims (2)
1. a kind of preparation method for adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition, it is characterised in that: plant Radix Glycyrrhizae
Object agglutinin is used to prepare the drug for increasing Bacillus acidi lactici quantity in woman vagina as active component.
2. a kind of pharmaceutical composition, it is characterised in that:
Using Radix Glycyrrhizae ribosome inactivating protein, mannosan, oligosaccharide or/and glucose, Bletilla glucomannan as active component, active component
Between relative weight share are as follows: 0.5~1.0 part of Radix Glycyrrhizae ribosome inactivating protein, 1.5~3.0 parts of mannosan, oligosaccharide
Or/and 0.2~2.0 part of glucose, 0.2~0.5 part of Bletilla glucomannan;
Either with Radix Glycyrrhizae ribosome inactivating protein, mannosan, oligosaccharide or/and glucose, Bletilla glucomannan, Radix Codonopsis extract,
Radix Berberidis extract, Rhizoma Atractylodis Macrocephalae extract are active component, the relative weight share between active component are as follows: Radix Glycyrrhizae RIP activity
0.5~1.0 part of albumen, 1.5~3.0 parts of mannosan, oligosaccharide or/and 0.2~2.0 part of glucose, Bletilla glucomannan 0.2~0.5
Part, one of Radix Codonopsis dry powder, barberry dry powder and Rhizoma Atractylodis Macrocephalae dry powder or more than one totally 1.0~3.0 parts of resulting extracts.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711110311.3A CN109771635A (en) | 2017-11-12 | 2017-11-12 | A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711110311.3A CN109771635A (en) | 2017-11-12 | 2017-11-12 | A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109771635A true CN109771635A (en) | 2019-05-21 |
Family
ID=66485465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711110311.3A Pending CN109771635A (en) | 2017-11-12 | 2017-11-12 | A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109771635A (en) |
-
2017
- 2017-11-12 CN CN201711110311.3A patent/CN109771635A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110016442B (en) | Application of lactobacillus rhamnosus and compound bacterium powder thereof in product for preventing and treating vaginitis | |
EP3520785B1 (en) | Uses of bacteriostatic agent formula in preparing composition for vaginal use and composition for vaginal use | |
CN101797304B (en) | Gel for adjusting microecology in vaginas of women | |
CN109394794A (en) | The composite probiotics preparations and preparation method of prophylactic treatment gynecological disease and application | |
CN103409334B (en) | Inhibit the Bacillus acidi lactici and application thereof of vaginitis pathogen | |
CN103157095B (en) | Kidney bean phytolectin applications in preparation of human drugs and drug composition thereof | |
WO2006001766A1 (en) | Composition comprising lactic acid and lactoferrin | |
CN110090195A (en) | A kind of women secret nursing gel and preparation method thereof | |
CN109985069B (en) | Probiotic compositions and uses thereof | |
CN111084831A (en) | Bacteriostatic composition for inhibiting vaginal pathogenic bacteria and application thereof | |
CN104870002A (en) | Chitin or derivatives thereof for the prevention and/or treatment of parasitoses | |
CN108042578A (en) | A kind of health care vaginal jellies containing compound probiotic ingredient | |
CN101797269A (en) | Physiological balance liquid for adjusting microecology in vaginas of women | |
RU2723015C2 (en) | Composition for maintenance of lactobacteria domination | |
CN110585418A (en) | External use disinfection essential oil emulsion for women and production process thereof | |
CN104069124A (en) | Composition and preparation for gynecologic infections | |
CN109464655B (en) | External capsule preparation for preventing and treating vaginitis | |
CN115517367B (en) | Application of lactobacillus paracasei SMN-LBK in preparation of intestinal health promoting product | |
CN109771635A (en) | A kind of preparation method adjusting women Bacillus acidi lactici microecological balance Chinese medicine composition | |
CN109771639A (en) | The application method of Radix Glycyrrhizae ribosome inactivating protein in medicine preparation | |
CN109771636A (en) | A method of preparation Traditional Chinese drug microecology composition is extracted by Radix Glycyrrhizae | |
CN102048729A (en) | Preparation for treating vaginitis | |
CN112057601B (en) | Preparation method of active probiotic freeze-dried powder and application of active probiotic freeze-dried powder in skin and gynecological diseases | |
CN105534948B (en) | A kind of vagina active bacteria formulation and preparation method thereof being stored at room temperature | |
WO2017193509A1 (en) | Bionic gynecological lotion and preparation method therefor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190521 |
|
WD01 | Invention patent application deemed withdrawn after publication |