CN109771095A - A kind of film covering type valve reparation clamp - Google Patents
A kind of film covering type valve reparation clamp Download PDFInfo
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- CN109771095A CN109771095A CN201910062578.2A CN201910062578A CN109771095A CN 109771095 A CN109771095 A CN 109771095A CN 201910062578 A CN201910062578 A CN 201910062578A CN 109771095 A CN109771095 A CN 109771095A
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- film coating
- clamp
- type valve
- valve reparation
- covering type
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Abstract
The invention belongs to medical device implants technical fields, more particularly to a kind of film covering type valve reparation clamp, including the first clamp and the second clamp, first clamp and the second clamp clamping are to form fixture, the fixture has overlay film, the overlay film includes inner film coating and outer film coating, and the inner film coating is wrapped in the sandwich part of fixture, and the outer film coating is wrapped in the outer surface of fixture.The present invention can effectively reduce thrombosis using the good blood compatibility of inner film coating and outer film coating and the good blood compatibility of contacting blood, keep the performance of normal blood flow biofluid environment.
Description
Technical field
The invention belongs to medical device implants technical fields, and in particular to a kind of film covering type valve reparation clamp.
Background technique
Heart is one of vertebrate organs.It is the power in the circulatory system.Human heart substantially with my fist
Size is the same, and the apex of the heart is biased to left.It on diaphragm, indulges between diaphragm, in the middle part of thoracic cavity lower section to the left, to the left between two lungs.Heart
It is made of cardiac muscle, four atrium sinistrum, left ventricle, atrium dextrum, right ventricle chamber compositions, wherein left ventricle inner wall is most thick, this four
A chamber is body circulation, the only way which must be passed of pulmonary circulation respectively.It is separated between left and right ventricles by interval between left atrium, therefore mutually
It is not communicated with, there is valve, i.e. atrioventricular valve between atrium and ventricle, these valves make blood that can only flow into ventricle by atrium, and cannot
It flows backwards.Action of the heart is to push blood flow, sufficient blood flow is provided to organ, tissue, to supply oxygen and various nutrition
Substance, and take away the final product of metabolism, such as carbon dioxide, inorganic salts, urea and uric acid, make cell maintain normal metabolism and
Function.
Valve is the membrane structure that can be opened and closed inside human organs.There are four valves in each human heart.Link
The aorta petal of left ventricle and aorta, connection right ventricle and pulmonary artery pulmonary valve, connection atrium sinistrum and left ventricle two
The tricuspid valve of cusp and connection atrium dextrum and right ventricle.They play one-way cock, flow blood can only from a direction
It cannot be flow backwards to another direction.For mitral position between atrium sinistrum and left ventricle, such as same one-way cock guarantees blood
It is flowed from atrium sinistrum to left ventricle direction and passes through certain flow.Mitral complex is one group of function and dissects complicated
Device, it is generally recognized that including annulus, leaflet, chordae tendineae and papillary muscle.Mitral valve prolapse, bicuspid valve retrogression, annulus of mitral valve calcium
Change, functionality mitral valve insufficiency caused by papillary muscle functional failure, left ventricular enlargement caused by myocardial ischemia, the infectious heart
Intimitis, congenital abnormality etc..Surgery prosthetic valve replacement operation wound is big, and the recovery time of patient is long, therefore to gerontal patient
Often avoid performing the operation because of advanced age, due to constitution is weak, lesion is heavy or merges Other diseases.
In recent years, with the progress of valve reparation treatment technology, valve reparation is developed rapidly and is applied to clinic,
Achieve more satisfied effect.By bicuspid valve or tricuspid valve in situ that film covering type valve reparation clamp is implanted to heart
In, related work is carried out to repair the natural valve of damage.But valve reparation clamp in the prior art and blood cannot be very
Good is compatible, and therefore, the application provides a kind of new technical solution, and in surgical procedure without opening chest, thus wound is small, postoperative extensive
It is multiple fast.
Summary of the invention
The purpose of the present invention is in view of the drawbacks of the prior art, providing a kind of film covering type valve reparation clamp, using interior
The good blood compatibility of layer overlay film and outer film coating and the good blood compatibility of contacting blood, can effectively reduce thrombus shape
At the performance of holding normal blood flow biofluid environment.
In order to achieve the goal above, the invention adopts the following technical scheme:
A kind of film covering type valve reparation clamp, including the first clamp and the second clamp, first clamp and the second clamp
Clamping is to form fixture, and the fixture has overlay film, and the overlay film includes inner film coating and outer film coating, the inner film coating packet
It is wrapped in the sandwich part of fixture, the outer film coating is wrapped in the outer surface of fixture.
Further, the inner film coating and/or outer film coating select following one or more structure combinations to connect with fixture
It connects: suture connection, bonding connection, the connection of own mechanical power.
Further, the structure of the outer film coating and/or inner film coating selects following one or more structures: densification knot
Structure, microcellular structure, foaming structure, micro-nano cavernous structure, non-woven constructions, matrix structure.
Further, the outer film coating and/or inner film coating are by applying layer building multilayer coating film structure.
Further, the inner film coating is the biological membrane material with good blood compatibility, and the outer film coating is
Reduce the biological membrane material of thrombosis.
Further, the material selection of the outer film coating one or more materials as follows: non-degradable high molecular material,
Degradable high polymer material, natural polymer.
Further, the outer film coating carries functional drug, for accelerating the endothelialization of valve reparation clamp.
Further, the material selection of the inner film coating one or more materials as follows: pass through bio-modification or carrying
Non-degradable macromolecule, degradable macromolecule, natural polymer, degradable high polymer material and the natural polymerization of functional drug
The copolymer or intermingling material of object.
Further, the valve reparation clamp is equipped with disposable protective layer, for protecting the valve reparation before use to press from both sides
Body.
Further, the inner film coating and/or outer film coating with a thickness of 0.0001mm-3.0mm.
Compared with prior art, the present invention beneficial effect is: being covered using the good blood compatibility of inner film coating and outer layer
Film and the good blood compatibility of contacting blood can effectively reduce thrombosis, keep the property of normal blood flow biofluid environment
Can, the endothelialization overlong time of hand postoperative implant is avoided, the success rate of operation and the convenience of surgical procedure are improved, it can be
The valve surface of Various Complex shape and structure is realized.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of film covering type valve reparation clamp of the present invention；
Wherein: 1. outer film coatings；2. inner film coating；3. fixture；4. the first clamp；5. the second clamp.
Specific embodiment
Illustrate embodiments of the present invention below by way of specific specific example, those skilled in the art can be by this specification
Other advantages and efficacy of the present invention can be easily understood for disclosed content.The present invention can also pass through in addition different specific realities
The mode of applying is embodied or practiced, the various details in this specification can also based on different viewpoints and application, without departing from
Various modifications or alterations are carried out under spirit of the invention.It should be noted that in the absence of conflict, following embodiment and implementation
Feature in example can be combined with each other.
Embodiment one:
As shown in Figure 1, the valve reparation clamp of the present embodiment is applied to medical device implants technical field, for damage
Bad valve is repaired.
It should be noted that the surface of fixture 3 is smooth surface, micropore surface, matte surface, serrated surface, groove table
One or more surface textures in face etc..
The present embodiment provides a kind of film covering type valve reparation clamp, including the first clamp 4 and the second clamp 5, the first clamps 4
With 5 clamping of the second clamp to form fixture 3, it is preferable that the first clamp 4 and the second clamp 5 pass through grafting formation fixture 3.It is described
There is overlay film, wherein overlay film includes inner film coating 2 and outer film coating 1, and inner film coating 2 is wrapped in the clamping of fixture 3 on fixture 3
Portion, outer film coating 1 are wrapped in the outer surface of fixture 3.
The structure of inner film coating 2 be compact texture, microcellular structure, foaming structure, micro-nano cavernous structure, non-woven constructions,
One or more mixed structures of matrix structure, can be micro- by electrochemical deposition, weaving, braiding, knitting, chemical attack, beam
The processing methods such as nanometer engraving are realized.For cooperating the different nip surfaces of fixture 3.
Inner film coating 2 with a thickness of 0.0001mm-3.0mm, and inner film coating 2 is using suture, bonding, own mechanical power
One or more modes are combined with fixture 3.Wherein, inner film coating material is made to be fixed on the clamping of fixture 3 by way of suture
Surface；It is, of course, also possible to which inner film coating material is made to be fixed on the nip surface of fixture 3 in such a way that adhesive is pasted；It can also
Inner film coating material is in conjunction with the micropore surface of fixture 3 by way of fibre prickling.
Inner film coating 2 passes through the coatings such as pneumatic spraying, piezoelectricity spraying, vacuum suction, negative ions solution LBL self-assembly
Method constructs one or more layers structure of film.
Inner film coating 2 is the biological membrane material with good blood compatibility.
Specifically, in the present embodiment, the material of inner film coating 2 be by bio-modification or carrying function drug not
Degradable macromolecule, such as: polyethylene, polyethylene terephthalate, polybutylene terephthalate, polytetrafluoroethylene (PTFE)；Or
Degradable macromolecule, such as: polyglycolide, polylactide, polycaprolactone；Or natural polymer, such as: collagen, pig collagen
Albumen, fibroin albumen, gelatin etc..In addition, degradable high polymer material can be used in the material of inner film coating 2, such as: polyglycolide,
Polylactide, polycaprolactone, polyglycolic acid one or more mixtures；Natural polymer, such as: bovine collagen albumen, pig collagen
Albumen, fibroin albumen, gelatin, astragalus polyose, albumin one or more mixtures；Can also for degradable high polymer material and
The copolymer or intermingling material of natural polymer.Inner film coating 2 reduces internal occupation time process for inducing guided tissue regeneration.
Inner film coating 2 and valve contact can effectively stick endothelial cell using the structure of inner film coating 2, promote cell point
Change proliferation, induce guided tissue regeneration, reduce volume, to repair damaged valve.
The structure of outer film coating 1 be compact texture, microcellular structure, foaming structure, micro-nano cavernous structure, non-woven constructions,
One or more mixed structures of matrix structure, can be micro- by electrochemical deposition, weaving, braiding, knitting, chemical attack, beam
The processing methods such as nanometer engraving are realized.For cooperating the different outer surfaces of fixture 3.
Outer film coating 1 with a thickness of 0.0001mm-3.0mm, and outer film coating 1 is using suture, bonding, own mechanical power
One or more modes are combined with fixture 3.Wherein, outer film coating material is made to be fixed on the appearance of fixture 3 by way of suture
Face；It is, of course, also possible to which outer film coating material is made to be fixed on the outer surface of valve reparation clamp 3 in such a way that adhesive is pasted；
Can also by way of fibre prickling outer film coating material in conjunction with the micropore surface of fixture 3.
Outer film coating 1 passes through the coatings such as pneumatic spraying, piezoelectricity spraying, vacuum suction, negative ions solution LBL self-assembly
Method constructs one or more layers structure of film.
Outer film coating 1 is the biological membrane material for reducing thrombosis.
Specifically, in the present embodiment, the material of outer film coating 1 be can be selected as non-degradable high molecular material, such as: poly- second
One kind of alkene, polyethylene terephthalate, polybutylene terephthalate, polytetrafluoroethylene (PTFE), polyurethane, polyether-ether-ketone etc. or
A variety of mixtures；The material of outer film coating 1 also can be selected as degradable high polymer material, such as: polyglycolide, polylactide, poly-
One or more mixtures of caprolactone, polyglycolic acid, polyadipate/butylene terephthalate etc.；The material of outer film coating 1
It also can be selected as natural polymer, such as: collagen, bovine collagen albumen, porcine collagen, fibroin albumen, gelatin, Radix Astragali are more
One or more mixtures of sugar, albumin etc..Outer film coating 1 and contacting blood have good blood compatibility, effectively subtract
Few thrombosis, keeps normal blood flow biofluid environment.
Outer film coating 1 carries functional drug, such as: pla-pcl, phosphatide, vascular endothelial growth factor accelerate valve
Film repairs the time of clamp endothelialization, restores damaged valve faster.
Valve reparation clamp, is also connected with conveying device, it is preferable that can be threadedly coupled conveying device, which is
Make operator by valve reparation clamp by sending the device to heart in vitro.
In addition, valve reparation clamp is also equipped with disposable protective layer, before being not used, valve reparation clamp is placed
In primary new protective layer, for protecting the valve reparation clamp before use not to be infected or damage.
In use, valve reparation clamp is transported at valve to be repaired by operator by conveying device, first is adjusted
The position of clamp 4 and the second clamp 5 connects the outer surface of inner film coating 2 and valve contact to be repaired, outer film coating 1 with blood
Touching, the first clamp 4 and 5 grafting of the second clamp are by valve clamping to be repaired.
The present invention utilizes the good blood compatibility of inner film coating and outer film coating and the good blood compatibility of contacting blood
Property, thrombosis can be effectively reduced, the performance of normal blood flow biofluid environment is kept, avoids the endothelialization of hand postoperative implant
Overlong time improves the success rate of operation and the convenience of surgical procedure, can be in the valve surface of Various Complex shape and structure
It realizes.
Embodiment two:
A kind of film covering type valve reparation clamp of the present embodiment and embodiment one the difference is that:
Outer film coating 1 is wrapped in the outside of inner film coating 2, and inner film coating 2 is wrapped in the outer surface of fixture 3, is applied to multiple
The valve surface of miscellaneous shape and structure.
Embodiment three:
A kind of film covering type valve reparation clamp of the present embodiment and embodiment one the difference is that:
Outer film coating 1 is wrapped in the outside of inner film coating 2, and outer film coating 1 is wrapped in the sandwich serface of fixture 3, is applied to multiple
The valve surface of miscellaneous shape and structure.
The present invention utilizes the good blood compatibility of inner film coating and outer film coating and the good blood compatibility of contacting blood
Property, thrombosis can be effectively reduced, the performance of normal blood flow biofluid environment is kept, avoids the endothelialization of hand postoperative implant
Overlong time improves the success rate of operation and the convenience of surgical procedure, can be in the valve surface of Various Complex shape and structure
It realizes.
It should be noted that above-described embodiment can be freely combined as needed.The above is only to of the invention excellent
Embodiment and principle is selected to be described in detail, for those of ordinary skill in the art, the thought provided according to the present invention,
It will change in specific embodiment, and these changes should also be regarded as the scope of the invention.
Claims (10)
1. a kind of film covering type valve reparation clamp, including the first clamp and the second clamp, first clamp and the second clamp folder
It closes to form fixture, which is characterized in that the fixture has overlay film, and the overlay film includes inner film coating and outer film coating, described
Inner film coating is wrapped in the sandwich part of fixture, and the outer film coating is wrapped in the outer surface of fixture.
2. a kind of film covering type valve reparation clamp according to claim 1, which is characterized in that the inner film coating and/or
Outer film coating selects following one or more structure combinations to connect with fixture: suture connection, bonding connection, own mechanical power connect
It connects.
3. a kind of film covering type valve reparation clamp according to claim 1 or 2, which is characterized in that the outer film coating and/
Or the structure of inner film coating selects following one or more structures: compact texture, microcellular structure, foaming structure, micro-nano poroid
Structure, non-woven constructions, matrix structure.
4. a kind of film covering type valve reparation clamp according to claim 1 or 2, which is characterized in that the outer film coating and/
Or inner film coating is by applying layer building multilayer coating film structure.
5. a kind of film covering type valve reparation clamp according to claim 1, which is characterized in that the inner film coating be with
The biological membrane material of good blood compatibility, the outer film coating are the biological membrane material for reducing thrombosis.
6. a kind of film covering type valve reparation clamp according to claim 5, which is characterized in that the material of the outer film coating
Select following one or more materials: non-degradable high molecular material, degradable high polymer material, natural polymer.
7. a kind of film covering type valve reparation clamp according to claim 6, which is characterized in that the outer film coating carries
Functional drug, for accelerating the endothelialization of valve reparation clamp.
8. a kind of film covering type valve reparation clamp according to claim 5, which is characterized in that the material of the inner film coating
Select following one or more materials: by the non-degradable macromolecule of bio-modification or carrying function drug, degradable height
Molecule, natural polymer, degradable high polymer material and natural polymer copolymer or intermingling material.
9. a kind of film covering type valve reparation clamp according to claim 1, which is characterized in that the valve reparation clamp is set
Once property protective layer, for protecting the valve reparation clamp before use.
10. a kind of film covering type valve reparation clamp according to claim 1, which is characterized in that the inner film coating and/or
Outer film coating with a thickness of 0.0001mm-3.0mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910062578.2A CN109771095A (en) | 2019-01-23 | 2019-01-23 | A kind of film covering type valve reparation clamp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910062578.2A CN109771095A (en) | 2019-01-23 | 2019-01-23 | A kind of film covering type valve reparation clamp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109771095A true CN109771095A (en) | 2019-05-21 |
Family
ID=66501944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910062578.2A Pending CN109771095A (en) | 2019-01-23 | 2019-01-23 | A kind of film covering type valve reparation clamp |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109771095A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111700714A (en) * | 2020-06-30 | 2020-09-25 | 上海市东方医院（同济大学附属东方医院） | Valve clip |
| WO2021018250A1 (en) * | 2019-07-31 | 2021-02-04 | 杭州德晋医疗科技有限公司 | Valve clamp having membrane and valve clamping system |
| CN113796993A (en) * | 2021-10-12 | 2021-12-17 | 科凯(南通)生命科学有限公司 | Clamp for repairing mitral valve stably in clamping manner |
| WO2022083027A1 (en) * | 2020-10-21 | 2022-04-28 | 江苏臻亿医疗科技有限公司 | Adjustable and removable valve clamping device |
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| CN111700714A (en) * | 2020-06-30 | 2020-09-25 | 上海市东方医院（同济大学附属东方医院） | Valve clip |
| CN111700714B (en) * | 2020-06-30 | 2023-02-28 | 上海市东方医院（同济大学附属东方医院） | Valve clip |
| WO2022083027A1 (en) * | 2020-10-21 | 2022-04-28 | 江苏臻亿医疗科技有限公司 | Adjustable and removable valve clamping device |
| CN113796993A (en) * | 2021-10-12 | 2021-12-17 | 科凯(南通)生命科学有限公司 | Clamp for repairing mitral valve stably in clamping manner |
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