CN109762735A - A kind of three dimensional biological printing ink-jet system - Google Patents
A kind of three dimensional biological printing ink-jet system Download PDFInfo
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- CN109762735A CN109762735A CN201910015632.8A CN201910015632A CN109762735A CN 109762735 A CN109762735 A CN 109762735A CN 201910015632 A CN201910015632 A CN 201910015632A CN 109762735 A CN109762735 A CN 109762735A
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- nozzle mechanism
- controller
- temperature
- dimensional biological
- jet system
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Abstract
The invention proposes a kind of three dimensional biologicals to print ink-jet system, including three dimensional biological printer；Three dimensional biological printer includes controller, nozzle mechanism, liquid feed device and temperature control device；Controller is connected separately nozzle mechanism and temperature control device；Nozzle mechanism connects liquid feed device；Nozzle mechanism is mounted on temperature control device；Temperature control device perceives the temperature of nozzle mechanism, and receives the signal of controller to keep nozzle mechanism constant temperature.Controller of the invention passes through the feedback of othermohygrometer sensor, adjust the operating temperature of refrigerating module in temperature control device, to realize the accurate monitoring to temperature and adjust in real time, reachable ± 0.1 DEG C of precision, guarantee that whole printing process is at a constant low temperature environment.
Description
Technical field
The invention belongs to new and high technology manufacture fields of biomedicine more particularly to a kind of three dimensional biological to print ink-jet system.
Background technique
Deepening continuously and practicing with accurate Medical Concept, medical domain is regenerated to tissue and body injury reparation
High-precision and individual demand gradually increasing.A kind of critical treatment means of the organ transplant as " precisely medical treatment ",
It is faced with organ supply and demand proportional imbalance (1:30) at present and transplants problem in short supply.3D printing technique is to popularize hair in recent years
A kind of rapid shaping technique of exhibition, the part complexity and fine degree of 3D printer production can be close to or up to manual polishing
Part, and manufacturing process is not necessarily to die sinking, so that 3D printer has huge use in terms of organ transplant and production application and dives
Power.
The temperature requirement that a critically important factor of 3D printing precision is printing head, existing 3D biology are influenced at present
Printing technique is difficult to meet low temperature environment required for cell keeps active, and cell structure in printing is easily made to change, is living
Property lose, so as to cause the tissue or organ printed be difficult to form even lose physiological activity.
Summary of the invention
The purpose of the present invention is to provide a kind of three dimensional biologicals to print ink-jet system, by setting temperature control device, so that
Nozzle mechanism keeps low temperature constant, solves problems of the prior art.To achieve the above object, of the present invention
Technical solution are as follows:
A kind of three dimensional biological printing ink-jet system, including three dimensional biological printer, the three dimensional biological printer include control
Device, nozzle mechanism, liquid feed device and temperature control device processed；
The controller is connected separately the nozzle mechanism and temperature control device；
The nozzle mechanism connects the liquid feed device；The nozzle mechanism is mounted on the temperature control device；The temperature
Control device perceives the temperature of the nozzle mechanism, and receives the signal of the controller to keep the nozzle mechanism constant temperature.
Preferably, the temperature control device includes control module, refrigerating module and air pressure temperature sensor；The control module
Refrigerating module and air pressure temperature sensor described in signal communication respectively；The othermohygrometer sensor perceives the nozzle mechanism
Signal is simultaneously fed back to the control module by temperature；The refrigerating module receives the signal of the control module and to nozzle mechanism
It is cooled down.
Preferably, the nozzle mechanism includes spray head, connector, glass capillary, piezoelectric element；The piezoelectric element packet
It is rolled on the outer wall of the glass capillary；The spray head is mounted on one end of the glass capillary；The connector installation
In the other end of the glass capillary；The piezoelectric element triggers the othermohygrometer sensor when expanding.
Preferably, the spray head is ultrasonic nozzle.
Preferably, the piezoelectric element includes piezoelectric body layer and is separately mounted on the piezoelectric body layer inner and outer wall
Electrode；The electrode being mounted on the inner wall is connect by conducting wire with the controller；The electrode being mounted on the outer wall is logical
Conducting wire is crossed to connect with the temperature sensor.
It preferably, further comprise the Analysis of Motion Control module being connected with the controller in a signal way. and electric drive；Institute
It states Analysis of Motion Control module and electric drive is separately mounted on the nozzle mechanism；The Analysis of Motion Control module receives
And analyze the motion state of nozzle mechanism；The electric drive receives the signal of the Analysis of Motion Control module by controller
To drive nozzle mechanism.
Preferably, the liquid supplying device includes print cartridge and the liquid storage bottle that is connected to print cartridge.
It preferably, further comprise vision inspection apparatus；The vision inspection apparatus is arranged in parallel with the nozzle mechanism；
The vision inspection apparatus is connected with the controller in a signal way..
Preferably, the vision inspection apparatus includes horizontal CCD camera and vertical CCD camera.
It preferably, further comprise Pneumatic controller；Controller described in the Pneumatic controller signal communication；It is described
Pneumatic controller is mounted on the nozzle mechanism.
Compared with prior art, advantages of the present invention are as follows:
1) nozzle mechanism includes spray head, connector, glass capillary, piezoelectric element and temperature sensor, and controller passes through
The feedback of othermohygrometer sensor adjusts the operating temperature of refrigerating module in temperature control device, to realize the accurate prison to temperature
Control and in real time adjusting, guarantee that whole printing process is at a constant low temperature environment by reachable ± 0.1 DEG C of precision；
2) system still can keep constant low temperature in the ultrahigh speed print procedure that spray head frequency reaches 30kHz, no
It can cause system heating that cell is caused to lose activity because of spray head high-frequency vibration；
3) the low temperature ultrasonic inkjet head refined can spray atomic small atomized drop to generate the coating of ultra-thin homogeneous,
Also it can make flow controllable precise；
4) this is compact-sized, possesses high texture appearance, and consumptive material is few, at low cost, and operation is easy, is safe and reliable.
Detailed description of the invention
Fig. 1 is that the three dimensional biological of one embodiment of the invention prints the structural framing figure of ink-jet system；
Fig. 2 is the structure chart of nozzle mechanism in Fig. 1；
Fig. 3 is the structural framing figure of temperature control device in Fig. 1；
Wherein, 1- three dimensional biological printer, 11- controller, 12- nozzle mechanism, 121- connector, 122- piezoelectric element,
123- spray head outer cover, conducting wire 124- conducting wire, 13- liquid feed device, 14- temperature control device, 141- control module, 142- refrigerating module,
143- othermohygrometer sensor, 15- vision inspection apparatus, 2- threedimensional model design station.
Specific embodiment
Three dimensional biological printing ink-jet system of the invention is described in more detail below in conjunction with schematic diagram, wherein table
Showing the preferred embodiment of the present invention, it should be appreciated that those skilled in the art can modify invention described herein, and still
Realize advantageous effects of the invention.Therefore, following description should be understood as the widely known of those skilled in the art, and
It is not intended as limitation of the present invention.
As shown in FIG. 1 to 3, a kind of three dimensional biological prints ink-jet system, including threedimensional model design station 2 and three-dimensional
Biometric print machine 1；Threedimensional model design station 2 exports print signal to three dimensional biological printer 1；Three dimensional biological printer 1
Including controller 11, nozzle mechanism 12, liquid feed device 13 and temperature control device 14；Controller 11 is connected separately nozzle mechanism 12
With temperature control device 14；Nozzle mechanism 12 connects liquid feed device 13；Nozzle mechanism 12 is mounted on temperature control device 14；Temperature control device 14
The temperature of nozzle mechanism 12 is perceived, and receives the signal of controller 11 to keep 12 constant temperature of nozzle mechanism.Threedimensional model designs work
Making station 2 as softwares, the main function such as CAD software or medicine 3D image collection, computer-aided three-dimensional design is to before printing
Data be collected and software modeling.
In the present embodiment, temperature control device 14 includes control module 141, refrigerating module 142 and air pressure temperature sensor
143；Control module 141 distinguishes signal communication refrigerating module 142 and air pressure temperature sensor 143；Othermohygrometer sensor 143 is felt
Know the temperature of nozzle mechanism 12 and signal is fed back into control module 141；The signal of the reception control module 141 of refrigerating module 142
And nozzle mechanism 12 is cooled down.Wherein refrigerating module 142 is connected with spray head screw thread builds low temperature environment, othermohygrometer sensing
Device 143 is connected to obtain actual temperature with spray head inner wall, and the real-time control to 12 temperature of nozzle mechanism is realized in control, guarantees constant low
Temperature state, to guarantee the survival rate and its biological function of cell to greatest extent, temperature control precision can reach ± 0.1
℃。
Liquid supplying device includes the liquid storage bottle that print cartridge is connected to print cartridge in the present embodiment.
As shown in Fig. 2, nozzle mechanism 12 includes spray head, connector 121, glass capillary, piezoelectric element 122；Piezoelectricity member
Part 122 is wrapped on the outer wall of glass capillary；Spray head is mounted on one end of glass capillary；Connector 121 is mounted on capillary
The other end of glass tube；Air pressure temperature sensor 143 is triggered when piezoelectric element 122 expands.Spray head is ultrasonic nozzle, fining
Low temperature ultrasonic inkjet head can spray atomic small atomized drop to generate the coating of ultra-thin homogeneous, can also flow be made accurately may be used
Control；Glass capillary is threadedly coupled by connector 121 with the print cartridge in liquid supplying device, only need to by selected timbering material with carefully
" bio-ink " is made in cytosol, and injects in corresponding liquid storage bottle, sets relevant print parameters, passes through the side of layer by layer deposition
Method carries out low-temperature biological printing shaping.For the service life for extending spray head, spray head outer cover 123 is made of ABS plastic, is had good
Good comprehensive physical mechanical property, it is heat-resisting, corrosion resistant, oil resistant, wear-resisting, spray head can be protected.Connector 121 and liquid supplying device screw thread are straight
Connect it is connected, guarantee liquid supplying device can keep good stability and leakproofness at -196 DEG C -300 DEG C, thus maximum limit
The survival rate of the guarantee cell printing of degree.
In the present embodiment, piezoelectric element 122 includes piezoelectric body layer and is separately mounted on piezoelectric body layer inner and outer wall
Electrode；The electrode being mounted on the inner wall is connect by conducting wire 124 with controller 11；The electrode of installation on the outer wall passes through
Conducting wire 124 is connect with temperature sensor.Controller 11 is connected with spray head tail portion by conducting wire 124, it can be achieved that need based jet and company
The printing model of continuous injection.
It in this embodiment, further comprise the Analysis of Motion Control module being connect with 11 signal of controller and electric drive；
Analysis of Motion Control module and electric drive are separately mounted on nozzle mechanism 12；Analysis of Motion Control module receives and analyzes spray
The motion state of head mechanism 12；Electric drive receives the signal of Analysis of Motion Control module by controller 11 to drive spray head machine
Structure 12, i.e. electric drive print required life to drive spray head to move on three-dimensional by the way of successively printing
Object tissue.
It in this embodiment, further comprise the Pneumatic controller being connect with 11 signal of controller；Pneumatic controller peace
On spray head；Pressure control dress is three condition pneumatic control system.Three condition pneumatic control system passes through in controller 11
Gas circuit control module 141 carries out real-time control to the pressure of spray head, internal pressure is provided to liquid supplying device, so that " bio-ink "
Uniformly outflow.Specifically, three condition pneumatic control system is responsible for keeping air pressure balance, drop is enable steadily to spray.Air pressure control
Device processed, by adjusting relevant parameter, makes it generate negative pressure between voltage rising period.Negative pressure is with the velocity of sound in a liquid along capillary
Glass tube is advanced, and aperture and feed flow end are arrived by way of extending sound wave, and accurate regulating liquid surface simultaneously controls printing model.Three condition
The airgun controller 11 of pneumatic control system includes single channel three condition gas control system, contains vacuum and positive pressure controller 11.It is for being
Fine liquid drop spray device provides stable back pressure, and positive pressure and negative pressure is selected quickly to supplement or empty liquid in spray head.Three condition
Pneumatic control system can be not only used for the temperature and regulating system air pressure of control low temperature spray head, and drop is steadily sprayed
Out, and cleaning sprayer can also use airgun controller 11, so that spray head is easily controllable and reuses.
It in this embodiment, further comprise vision inspection apparatus 15；The vision inspection apparatus 15 and the nozzle mechanism
12 are arranged in parallel；The vision inspection apparatus 15 is connect with 11 signal of controller.Vision inspection apparatus 15 includes horizontal CCD
Camera, vertical CCD camera and with LED stroboscopic lamp.Nozzle mechanism 12 is under the regulation of motion control device, with the speed of 50mm/s
Custom script program, horizontal CCD camera, vertical CCD camera and with LED stroboscopic lamp can by contraposition identification, benchmark is to bitmap
As the methods of analysis is immediately monitored the state of drop.Vision inspection apparatus 15 simultaneously with motion control and analysis system phase
Even, it is therefore intended that monitoring nozzle position and ink-jet situation, and timely feedback and be connected to Analysis of Motion Control module, to the fortune of spray head
Dynamic state is accurately adjusted.
The system still can keep constant low temperature in the ultrahigh speed print procedure that spray head frequency reaches 30kHz, will not
Cause system heating that cell is caused to lose activity because of spray head high-frequency vibration.After printing is complete, which can still realize low
Temperature saves cell.Low temperature environment in print procedure does not influence increment and the differentiation capability of cell, and the cell for printing completion is logical
Cryo-conservation is crossed, though it is in undifferentiated dormant state, the hyperproliferation potential with self-renewing.
The operation principle of the present invention is that:
(1) medicine 3D can be passed through by establishing the computer mock-up for the implant to be printed or user with CAD software
The technologies such as image collection, computer-aided three-dimensional design are collected to the data before printing and software modeling.
(2) a variety of timbering materials and various kinds of cell liquid for needing to carry out organizational project Organ printing are prepared；
(3) prepared timbering material and cell liquid are added separately to print the liquid storage bottle of the liquid supplying device of the material
Interior, timbering material and cell liquid enter in print cartridge；When liquid is to flow through glass capillary at a high speed, piezoelectric element 122 will appear
Voltage difference generates electric field inside piezoelectric element 122, between the electrode of outside, so that the expansion of piezoelectric element 122 is to trigger gas
Temperature sensor 143 is pressed, under the action of controller 11 and refrigerating module 142, nozzle mechanism 12 maintains constant low temperature environment.
(4) model file will be designed to be input in the controller 11 of the printer, related printing parameters is set, control should
Printer work.
(5) the cryogenic sterile environment of the internal system can carry out subsequent cryo-conservation to the cell printed, construct symbol
Close desired various organisms.
To sum up, it in three dimensional biological provided in this embodiment printing ink-jet system, has the advantage that
1) nozzle mechanism 12 includes spray head, connector 121, glass capillary, piezoelectric element 122 and temperature sensor, control
Device 11 processed passes through the feedback of othermohygrometer sensor 143, adjusts the operating temperature of refrigerating module 142 in temperature control device 14, thus
Realize to temperature it is accurate monitoring and in real time adjusting, reachable ± 0.1 DEG C of precision, guarantee whole printing process be at one it is constant
Low temperature environment；
2) system still can keep constant low temperature in the ultrahigh speed print procedure that spray head frequency reaches 30kHz, no
It can cause system heating that cell is caused to lose activity because of spray head high-frequency vibration；
3) the low temperature ultrasonic inkjet head refined can spray atomic small atomized drop to generate the coating of ultra-thin homogeneous,
Also it can make flow controllable precise；
4) this is compact-sized, possesses high texture appearance, and consumptive material is few, at low cost, and operation is easy, is safe and reliable.
The above is only a preferred embodiment of the present invention, does not play the role of any restrictions to the present invention.Belonging to any
Those skilled in the art, in the range of not departing from technical solution of the present invention, to the invention discloses technical solution and
Technology contents make the variation such as any type of equivalent replacement or modification, belong to the content without departing from technical solution of the present invention, still
Within belonging to the scope of protection of the present invention.
Claims (10)
1. a kind of three dimensional biological prints ink-jet system, which is characterized in that including three dimensional biological printer；
The three dimensional biological printer includes controller, nozzle mechanism, liquid feed device and temperature control device；
The controller is connected separately the nozzle mechanism and temperature control device；
The nozzle mechanism connects the liquid feed device；The nozzle mechanism is mounted on the temperature control device；The temperature control dress
The temperature for perceiving the nozzle mechanism is set, and receives the signal of the controller to keep the nozzle mechanism constant temperature.
2. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that the temperature control device includes control
Module, refrigerating module and air pressure temperature sensor；Refrigerating module and othermohygrometer described in the control module difference signal communication
Sensor；The othermohygrometer sensor perceives the temperature of the nozzle mechanism and signal is fed back to the control module；Institute
Refrigerating module is stated to receive the signal of the control module and cool down nozzle mechanism.
3. three dimensional biological according to claim 2 prints ink-jet system, which is characterized in that the nozzle mechanism includes spray
Head, connector, glass capillary, piezoelectric element；The piezoelectric element is wrapped on the outer wall of the glass capillary；The spray
Head is mounted on one end of the glass capillary；The connector is mounted on the other end of the glass capillary；The piezoelectricity
Element triggers the othermohygrometer sensor when expanding.
4. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that the spray head is ultrasonic nozzle.
5. three dimensional biological according to claim 2 prints ink-jet system, which is characterized in that the piezoelectric element includes piezoelectricity
Body layer and the electrode being separately mounted on the piezoelectric body layer inner and outer wall；The electrode being mounted on the inner wall passes through conducting wire
It is connect with the controller；The electrode being mounted on the outer wall is connect by conducting wire with the temperature sensor.
6. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that further comprise and the control
The Analysis of Motion Control module and electric drive of device signal connection；The Analysis of Motion Control module and electric drive are installed respectively
On the nozzle mechanism；The Analysis of Motion Control module receives and analyzes the motion state of nozzle mechanism；The electric drive
Device receives the signal of the Analysis of Motion Control module by controller to drive nozzle mechanism.
7. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that the liquid supplying device includes print cartridge
The liquid storage bottle being connected to with print cartridge.
8. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that further comprise vision-based detection dress
It sets；The vision inspection apparatus is arranged in parallel with the nozzle mechanism；The vision inspection apparatus and the controller signals connect
It connects.
9. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that the vision inspection apparatus includes
Horizontal CCD camera and vertical CCD camera.
10. three dimensional biological according to claim 1 prints ink-jet system, which is characterized in that further comprise pressure control
Device；Controller described in the Pneumatic controller signal communication；The Pneumatic controller is mounted on the nozzle mechanism.
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| CN201910015632.8A CN109762735A (en) | 2019-01-08 | 2019-01-08 | A kind of three dimensional biological printing ink-jet system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910015632.8A CN109762735A (en) | 2019-01-08 | 2019-01-08 | A kind of three dimensional biological printing ink-jet system |
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| CN109762735A true CN109762735A (en) | 2019-05-17 |
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| CN104758085A (en) * | 2014-12-26 | 2015-07-08 | 南京师范大学 | Three dimensional biology printing device and method |
| CN106313532A (en) * | 2015-06-15 | 2017-01-11 | 成都金采科技有限公司 | 3D printer printing head |
| CN205443250U (en) * | 2015-12-21 | 2016-08-10 | 青岛尤尼科技有限公司 | Piezoelectricity shower nozzle device and 3D printer of cell printout |
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