CN109758661A - A kind of preforming seal wire for the treatment of intravascular bifurcated lesions - Google Patents
A kind of preforming seal wire for the treatment of intravascular bifurcated lesions Download PDFInfo
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- CN109758661A CN109758661A CN201910047229.3A CN201910047229A CN109758661A CN 109758661 A CN109758661 A CN 109758661A CN 201910047229 A CN201910047229 A CN 201910047229A CN 109758661 A CN109758661 A CN 109758661A
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- seal wire
- rear end
- intravascular
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Abstract
The present invention relates to a kind of preforming seal wires for the treatment of intravascular bifurcated lesions.The core material of the preforming seal wire for the treatment of intravascular bifurcated lesions includes front end, rear end and bending part；The bending part includes the first bending part and the second bending part；First bending part is bent from the head of the front end to the direction close to the rear end；Second bending part is bent from the tail portion of first bending part to the direction far from the first bending part axis；It seamlessly transits between first bending part and front end, is seamlessly transitted between first bending part and the second bending part.The preforming seal wire that the present invention obtains has handling good push torsion, flexibility, super-elasticity and safety.
Description
Technical field
The present invention relates to medical fields, and in particular to it is a kind of for intravascular bifurcated lesions treatment preforming seal wire and its
Preparation method.
Background technique
In organism, especially lumens such as the intracorporal blood vessel of people, respiratory tract, alimentary canal, ear canal, nasal cavity exist a large amount of
Branch line, but due to the special air-flow and liquid flow characteristics of branch, such branch is the district occurred frequently of all kinds of obstructions and infection
Domain.The interventional therapy of the bracket, sacculus and drug release that are mediated using seal wire, be the therapeutic modality that quickly grows at present it
One.
Bifurcation coronary artery accounts for about the 20-30% in Coronary Artery Disease Intervention Treatment field, is common clinical problem, simultaneously
It is also most challenging one of the lesion in percutaneous coronary intervention field.The treatment operation difficulty of bifurcation coronary artery
Greatly, success rate of operation is low, and complication rate is high, and long-term effect is poor.
In the blood vessels during interventional therapy, seal wire enter lumen of vessels after, need by blood vessel internal channel, branch and
Wriggle meandering part, even needs to break through narrow positions and reaches target area sometimes, thus by other interventions such as conduit, microtubular
Medical device is guided to corresponding site or region.Therefore, interventional therapy operation in the blood vessels is especially thin in coronary artery, encephalic
In the treatments of lesions positions such as the small supply vessels in small cerebral artery, vascular malformation and tumour, the performance of seal wire ties treatment
Fruit has vital influence.
In order to reach ideal therapeutic effect, it is handling that seal wire needs excellent push to reverse, and due to seal wire diameter
It is tiny, when it also being required to pass through and push in curved blood vessel, deformed after being not susceptible to bending.Further, since seal wire it is thin and
It is long, therefore seal wire front end is also required to be easy to import blood vessel and by vascular bending section or breakthrough narrow positions.Finally, due to very much
Thin vessels tube wall strength it is small, seal wire must also show good flexibility and super-elasticity as far as possible, with reduce and vascular wall
Surface occur friction and and damage vascular wall a possibility that.
Push can be had both by, which lacking in the prior art, reverses handling, flexibility and hyperelastic seal wire, in addition, existing skill
Seal wire in art is in the treatment of coronary artery bifurcated lesions, however it remains it is following insufficient: firstly, common seal wire conveyed in the blood vessel
Cheng Zhong, needs to enter by way of " turning on one's heel " in certain important branch blood vessels branch line, and these pipelines
It is difficult that seal wire passes through, it is often necessary to intervene doctor and carry out manual processing for seal wire front end, repeatedly debug " taking a chance ", institute
What seal wire processed could meet branch's lesion passes through requirement；In addition, to plaque load weight bifurcated lesions carry out by when, by spot
The occupy-place of block influences, and branch vessel can occur " trend of taking advantage of a situation " line branches region passes through difficulty.
Therefore, one kind is obtained by preforming, and there is good push to reverse handling, flexibility and hyperelastic seal wire,
And it can avoid due to the winding between seal wire caused by " sound out and pass through ", while " sound out and pass through " also being avoided repeatedly to cause
Blood vessel acute occlusion, the treatment to intravascular bifurcated lesions, has highly important positive effect.
Summary of the invention
To overcome defect and deficiency existing in the prior art, the invention discloses one kind to control for intravascular bifurcated lesions
The preforming seal wire and preparation method thereof treated.
The invention is realized by the following technical scheme:
A kind of preforming seal wire for the treatment of intravascular bifurcated lesions: the core material of the preforming seal wire includes front end
Portion, rear end and bending part；The bending part includes the first bending part and the second bending part；First bending part is by before described
The head of end is bent to the direction close to the rear end；Second bending part is from the tail portion of first bending part to remote
Direction bending from the first bending part axis；It is seamlessly transitted between first bending part and front end, described first is curved
It is seamlessly transitted between folding part and the second bending part.
Further, second bending part is bent along the radial direction of the core material.
Further, the outer peripheral edge of the front end and bending part is wound with coil.
Further, the front end and bending part are integrally formed；The front end and rear end are passed through sharp using solder
Photocoagulation is interconnected and fixed；The rear end has cylindrical structure；The front end has from close to the rear end
The conical structure that one end is gradually reduced to one end diameter far from the rear end；The diameter of the bending part and the front end
Minimum diameter of the portion on the end position far from the rear end is equal.
Further, the front end is equipped with stepped cylindrical boss；The rear end is equipped with hollow circuit cylinder boss；It will be described
After stepped cylindrical projection section protrudes into the hollow circuit cylinder boss, laser welding is passed through for the stepped cylindrical boss using solder
It connects fixation with hollow circuit cylinder boss；Or, the front end is equipped with hollow circuit cylinder boss；The rear end is equipped with stepped cylindrical
Boss；It, will be described by laser welding using solder after the stepped cylindrical projection section is protruded into the hollow circuit cylinder boss
Stepped cylindrical boss and hollow circuit cylinder boss connect fixation；
Further, the coil include coaxial arrangement Inside coil and external coil, the external coil around
The outside of the Inside coil；One end of the external coil is welded to each other with the front end by the first joint portion and is connect,
The other end is welded to each other with the tail end of second bending part by the second joint portion and is connect；One end of the Inside coil passes through
First joint portion is welded to each other with the front end and connect, and the other end passes through the tail end at third joint portion and first bending part
It is welded to each other connection；The diameter of the external coil is from one end close to first joint portion to close to second joint portion
One end be gradually increased；The diameter of the Inside coil is engaged from one end close to first joint portion to close to the third
The one end in portion is gradually reduced.
Further, the core material is using any one system in stainless steel material, nickel-titanium alloy material, gold, platinum
At the coil is made of any one in stainless steel material, nickel-titanium alloy material, gold, platinum；The rear end
Outer peripheral edge is coated with resin layer；The outer peripheral edge of the front end and bending part is coated with silver-colored strontium alloy layer；The coil
Outer peripheral edge is coated with layered double-hydroxide layer.
A kind of preparation method of the preforming seal wire for the treatment of intravascular bifurcated lesions, the preforming seal wire includes core
Material and coil；The core material and coil are respectively adopted nickel-titanium alloy material and are made；The core material includes front end, rear end and curved
Folding part；The outer peripheral edge of the front end and bending part is wound with coil；The coil include coaxial arrangement Inside coil and
External coil, the external coil is around the outside of the Inside coil；The preforming seal wire is obtained by following steps:
S1. resin cladding pretreatment is carried out to the rear end；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end and bending part；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil；
S4. the front end and rear end are interconnected and fixed using solder by laser welding；
S5. the Inside coil is wound in the outer peripheral edge of the front end and bending part, by the Inside coil
One end be welded to each other with the first joint portion, and the other end of the Inside coil and third joint portion are welded to each other；
S6., the external coil is wound in the outside of the Inside coil, by one end of the external coil and first
Joint portion is welded to each other, and the other end of the external coil and the second joint portion are welded to each other.
Further, in the preparation method of the preforming seal wire for the treatment of intravascular bifurcated lesions, before described
End is equipped with stepped cylindrical boss；The rear end is equipped with hollow circuit cylinder boss；In step s 4, by the stepped cylindrical boss
After partially protruding into the hollow circuit cylinder boss, using solder along the ladder for being exposed to outside for not extending into the hollow circuit cylinder boss
Cylinder boss carries out laser welding, and the front end is fixedly connected with rear end.
Compared with prior art, the present invention the advantage is that:
1. the preforming seal wire has handling good push torsion, flexibility, super-elasticity and biological safety, and makes
It can be avoided due to the winding between seal wire caused by " sound out and pass through ", while " sound out and pass through " also being avoided repeatedly to cause blood vessel
Acute occlusion；
2. the present invention can be improved procedure efficiency, the time of patient's shaped by hand seal wire repeatedly is reduced, shortens operating time, subtracts
Few branch's occlusion, reduces complication；
3. weld seam cracks between the avoidable front end of the present invention and rear end, guarantee the coaxial of front end and rear end
Welding guarantees and improves the service life of core material.Its safety is improved, and avoids replacing seal wire in surgical procedure, reduces operation
Cost improves procedure efficiency；
4. the biological safety of preforming seal wire of the invention is high, it is not easy to cause allergy and postoperative infection.
Detailed description of the invention
Fig. 1: the first signal of the core material of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention
Figure；
Fig. 2: the lesion schematic diagram for the branch vessel that turns on one's heel；
Fig. 3: patch occupy-place, which causes to take advantage of a situation, moves towards the lesion schematic diagram of branch vessel；
Fig. 4: preforming seal wire the answering in branch's lesion for the treatment of intravascular bifurcated lesions of the embodiment of the present invention
Use schematic diagram；
Fig. 5: the second signal of the core material of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention
Figure；
Fig. 6: the front end and rear end of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention
First welding schematic diagram；
Fig. 7: the front end and rear end of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention
Second welding schematic diagram；
Fig. 8: the coil schematic diagram of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention；
Fig. 9: the portion the A enlarged drawing of the preforming seal wire for the treatment of intravascular bifurcated lesions of the embodiment of the present invention.
Description of symbols:
Core material -1, front end -11, stepped cylindrical boss -111, rear end -12, hollow circuit cylinder boss -121, bending part -
13, first bending part -131, the second bending part -132, coil -2, Inside coil -21, external coil -22, the first joint portion -
31, the second joint portion -32, third joint portion -33, solder -4, main branch vessel-A, bifurcated vessels-B, lesion-C, seal wire-D are led
Pipe-E.
Specific embodiment
In order to enable the purposes, technical schemes and advantages of technical solution of the present invention are clearer, below in conjunction with this
The technical solution of the embodiment of the present invention is clearly and completely described in the attached drawing of invention specific embodiment.Before reconcilable
It puts, the technical characteristic in each embodiment of the present invention can be combined with each other.
As shown in attached drawing 1 and 5, the embodiment of the invention provides a kind of preforming leading for the treatment of intravascular bifurcated lesions
Silk, the core material 1 of the preforming seal wire include front end 11, rear end 12 and bending part 13；The bending part 13 includes first
Bending part 131 and the second bending part 132；First bending part 131 is from the head of the front end 11 to close to the rear end
The direction in portion 12 is bent；Second bending part 132 is from the tail portion of first bending part 131 to far from first bending part
The direction of 131 axis is bent；It is seamlessly transitted between first bending part 131 and front end 11, first bending part 131
And second seamlessly transit between bending part 132.
Preferably, second bending part 132 is bent along the radial direction of the core material 1.At this point, the preforming seal wire
Coplanarity it is preferable when, seal wire is in intracavitary propulsion and in the more smooth in place of lesion locations and saves the time.
In some embodiments of the invention, the outer peripheral edge of the front end 11 and bending part 13 is wound with coil 2.
The front end 11, bending part 13 and coil 2 can be used the noble metals such as the superelastic alloy such as Nitinol or gold and silver and be made, described
The noble metals such as the superelastic alloy such as Nitinol or gold and silver can be used in rear end 12 or steel wire is made.The front end 11 and bending
Portion 13 is integrally formed.The front end 11 and rear end 12 are interconnected and fixed using solder 4 by laser welding.
The rear end 12 has cylindrical structure.The front end 11 have from close to the rear end 12 one end to
The conical structure that one end diameter far from the rear end 12 is gradually reduced, the diameter of the bending part 13 and the front end
11 minimum diameter on the end position far from the rear end 12 is equal.By above structure, may make described preforming
The front end of seal wire has good pliability, and avoids damage to blood vessel, guarantees its good safety.
In some embodiments of the invention, first bending part 131 is from the head of the front end 11 to close
The angle of the direction bending of the rear end 12 is 110 ° -180 °.Preferably, first bending part 131 is by the front end
The angle that 11 head is bent to the direction close to the rear end 12 is 130 ° -180 °.
In some embodiments of the invention, the length of first bending part 131 is 0.5-5 centimetres.Preferably,
The length of first bending part 131 is 1-4 centimetres.The length of second bending part 132 is 0.1-2 centimetres.Preferably, institute
The length for stating the second bending part 132 is 0.1-1 centimetres.It is further preferred that the length of second bending part 132 is 0.1-
0.5 centimetre.
Two-chamber or multi-cavity microtubular can be used the preforming seal wire is delivered in blood vessel, for treatment blood vessel,
Respiratory tract, alimentary canal, ear canal, nasal cavity bifurcated lesions.The reason of preforming seal wire is designed as above structure is: general
Admittance silk in transmission process, needs to see Figure of description 2 by " turning on one's heel " in certain important branch blood vessels in the blood vessel
Mode enter branch line, and the seal wire of these pipelines pass through it is difficult, it is often necessary to before intervening doctor for seal wire
End carry out manual processing, repeatedly debug " taking a chance ", made seal wire can just meet branch's lesion by requiring "；It is negative to patch
The bifurcated lesions of loading carry out by when, the occupy-place by patch is influenced, even if " trend of taking advantage of a situation is shown in Figure of description 3 " pipeline point
What branch vessel can also occur for fork region passes through difficulty；The use of preforming seal wire can also avoid causing due to " sound out and pass through "
Seal wire between winding, while " sound out by " also being avoided repeatedly to cause blood vessel acute occlusion.It clinically needs to have and pass through
Property it is good, easily operated seal wire is for clinical alternative.
In order to avoid the above problem, the bending is arranged in the front end 11 of the core material 1 of the preforming seal wire in the present invention
Portion 13 enables preforming seal wire to be more easier to pass through at bifurcated lesions position；Also, in the bifurcated lesions that treatment is complicated
When, the surface of preforming seal wire is smooth, seal wire internal stress and stable structure, is not susceptible to fracture and the scuffing to blood vessel；This
Outside, the present invention can be improved procedure efficiency, reduces the time of patient's shaped by hand seal wire repeatedly, shortens operating time, reduce branch
Occlusion reduces complication.Finally, preforming seal wire can also be further processed, the spy of various special branch's lesions is adapted to
It is different to require.To sum up, the bending part 13 is arranged by the front end 11 of the core material 1 in the preforming seal wire can be improved seal wire
Pass through efficiency, reduce consumptive material and use, reduce surgery cost and cost.
Shown in Fig. 4, A is main branch vessel, and B is bifurcated vessels, and C is lesion, and D is the seal wire-D, E for protruding into main branch vessel A
For conduit.When there is the lesion of branch part in the blood vessel, preforming seal wire of the invention can successively according to step a, b, c,
D passes through space occupying lesion, into bifurcated vessels B, it should be noted that bifurcated vessels are also likely to be main branch vessel.In reality
During trampling, the operation that preforming seal wire of the invention mediates, only on total time, than the intervention of common seal wire operation when
It is long, it is more than hour to shorten one.
It, can be by following structures and methods, before described in some embodiments of the invention as shown in attached drawing 6-7
End 11 and rear end 12 are interconnected and fixed using solder 4 by laser welding: it is convex that the front end 11 is equipped with stepped cylindrical
Platform 111；The rear end 12 is equipped with hollow circuit cylinder boss 121；The stepped cylindrical boss 111 is partially protruded into the hollow circle
After column boss 121, the stepped cylindrical boss 111 and hollow circuit cylinder boss 121 are interconnected by laser welding using solder 4
Connect fixation.Alternatively, the rear end 12 is equipped with stepped cylindrical boss 111；The front end 11 is equipped with hollow circuit cylinder boss 121；
After the stepped cylindrical boss 111 is partially protruded into the hollow circuit cylinder boss 121, laser welding is passed through for institute using solder 4
It states stepped cylindrical boss 111 and hollow circuit cylinder boss 121 connects fixation.
The solder 4 is unwelded preceding for plate-like solder or strip solder.When welding, the molten shape object of the solder 4 is filled
It is combined in the gap location of the stepped cylindrical boss 111 and hollow circuit cylinder boss 121, and by the front end 11 and rear end 12
The outer peripheral edge at place coats completely.By the above-mentioned means, being avoided that weld seam cracks, guarantee and improve the use longevity of core material 1
Life.
If attached drawing 8-9 shows, in some embodiments of the invention, the coil 2 includes the Inside coil of coaxial arrangement
21 and external coil 22, the external coil 22 is around the outside of the Inside coil 21.One end of the external coil 22
It is welded to each other and is connect with the front end 11 by the first joint portion 31, the other end is curved by the second joint portion 32 and described second
The tail end of folding part 132 is welded to each other connection；One end of the Inside coil 21 passes through the first joint portion 31 and the front end 11
It is welded to each other connection, the other end is welded to each other with the tail end of first bending part 131 by third joint portion 33 and is connect.It is described
Inside coil 21 continues forward after being welded to each other connection by the tail end at third joint portion 33 and first bending part 131
Winding, avoids falling off for the Inside coil 21.
It is first that one end of the Inside coil 21 is mutual by the first joint portion 31 and the front end 11 in welding
It is welded to connect, then winds the Inside coil 21 on the core material 1, and the Inside coil 21 is passed through into third joint portion
33 are welded to each other with the tail end of first bending part 131 and connect, and in turn, one end of the external coil 22 is connect by first
Conjunction portion 31 is welded to each other with the front end 11 and connect, and the external coil 22 is wound in the outside of the Inside coil 21,
Finally, the other end of the external coil 22 is mutually welded by the second joint portion 32 and the tail end of second bending part 132
It connects in succession.
The diameter of the external coil 22 is from one end close to first joint portion 31 to close to second joint portion
32 one end is gradually increased；The diameter of the Inside coil 21 is from one end close to first joint portion 31 to close to described the
The one end at three joint portions 33 is gradually reduced.
The front end 11 and bending can be improved in the Inside coil 21 and external coil 22 gradually changed respectively by diameter
The flexibility in portion 13 and restoring type make it particularly suitable for the treatment of bifurcated lesions.Further, since the embodiment of the present invention it is pre- at
A possibility that flexibility of type seal wire is higher, thus its is easy to operate, is strayed into blood vessel substantially reduces.Due to 11 He of front end
The double layer design of 13 lower, the flexible relative of rigidity of bending part, Inside coil 21 and external coil 22 can avoid the front end 11
Plastic deformation occurs with bending part 13, improves its safety, and avoid replacing seal wire in surgical procedure, reduces operation cost, mentions
High procedure efficiency.
The materials such as metal, alloy, Steel material, high molecular material can be used in core material 1 described in the embodiment of the present invention and coil 2
It is made.Preferably, core material 1 described in the embodiment of the present invention is using in stainless steel material, nickel-titanium alloy material, gold, platinum
Any one is made, and the coil 2 is made of any one in stainless steel material, nickel-titanium alloy material, gold, platinum.
The resin layer of the rear end 12 can be acrylic resin, silane resin, polyurethane resin, phenolic resin, urea
The materials such as urea formaldehyde are made.The outer peripheral edge of the front end 11 and bending part 13 is coated with alloy-layer, and the alloy-layer is silver
Strontium alloy layer, silver-colored titanium alloy layer, any one in titanium strontium alloy layer.
In some embodiments of the invention, the core material 1 uses stainless steel material and/or nickel-titanium alloy material system
At the coil 2 is made of nickel-titanium alloy material.The outer peripheral edge of the rear end 12 is coated with resin layer；The front end
The outer peripheral edge of portion 11 and bending part 13 is coated with silver-colored strontium alloy layer；The outer peripheral edge of the coil 2 is coated with the double hydrogen-oxygens of stratiform
Compound layer.
The reason of outer peripheral edge in the rear end 12 resin-coated layer, is: the rear end can be improved by resin layer
The hydrophily and pliability of the outer peripheral edge in portion 12 make it have under the premise of not reducing rigidity and push torsion is handling
Good flexibility, elasticity and biocompatibility, with reduce with blood vessel wall surface occur friction and and damage vascular wall can
It can property.It is in the reason of outer peripheral edge coated with silver strontium alloy layer of the front end 11 and bending part 13: nickel-titanium alloy material
Although having good shape memory effect, toxic free nickel ion can be discharged after entering human body, so that preforming lead
The biological safety of silk reduces, and easily causes allergy and postoperative infection, therefore, by the front end of nickel-titanium alloy material
The outer peripheral edge coated with silver strontium alloy layer in portion 11 and bending part 13, can inhibit the precipitation of free nickel ion, in addition silver-colored strontium alloy sheet
Body has good antibacterial bacteriostatic performance, thus can effectively reduce allergy and postoperative infection risk.In the external week of the coil 2
Edge, the i.e. outer peripheral edge of Inside coil 21 and external coil 22 are coated with the reason of layered double-hydroxide layer and are: firstly, trip
From biocompatibility and the safety that nickel ion can reduce by 2 part of coil, and there is layered double-hydroxide unique anion to hand over
Transducing power and biocompatibility is excellent, thus its biocompatibility that 2 part of low coil not only can be improved, apply also for drug
Load.
Specifically, the preforming seal wire is obtained by following steps:
S1. resin cladding pretreatment is carried out to the rear end 12；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end 11 and bending part 13；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil 2；
S4. the front end 11 and rear end 12 are interconnected and fixed using solder 4 by laser welding, specifically,
After the stepped cylindrical boss 111 is partially protruded into the hollow circuit cylinder boss 121, using solder 4 along not extending into described
The external stepped cylindrical boss 111 that is exposed to of hollow round column boss 121 carries out laser welding, by the front end 11 and rear end 12
It is fixedly connected；
S5. the Inside coil 21 is wound in the outer peripheral edge of the front end 11 and bending part 13, it will be described interior
One end of portion's coil 21 is welded to each other with the first joint portion 31, and by the other end of the Inside coil 21 and third joint portion 33
It is welded to each other；
S6., the external coil 22 is wound in the outside of the Inside coil 21, by one end of the external coil 22
It is welded to each other with the first joint portion 31, and the other end of the external coil 22 and the second joint portion 32 is welded to each other.
In step sl, resin cladding pretreatment is carried out to the rear end 12 by the following method:
S1-1. by the rear end 12 in the aqueous hydrochloric acid solution that concentration is 10wt%-20wt% and 30 DEG C -40 DEG C
40min-60min is impregnated under the conditions of temperature；
S1-2. by the rear end 12 by step S1-1 processing in the sodium bicarbonate that concentration is 5wt%-15wt%
80min-120min is impregnated in aqueous solution and under the conditions of 50 DEG C -60 DEG C of temperature；
S1-2. 10min- will be impregnated in the polyamide of flowing by the rear end 12 of step S1-2 processing
It is taken out after 20min.
In step s 2, metal is carried out to the integrally formed front end 11 and bending part 13 by the following method to splash
Penetrate deposition pretreatment:
S2-1., the integrally formed front end 11 and bending part 13 are put into the vacuum chamber of plasma alloying equipment
In interior tubular sample stage, the silver-colored strontium alloy target containing 2-5% mass fraction silver is placed horizontally on tubular sample stage, adjustment silver
The distance between strontium alloy target and the integrally formed front end 11 and bending part 13 are 20cm-40cm；
S2-2. the air pressure of vacuum chamber is evacuated to vacuum by venthole with vacuum evacuation device, then by air inlet to true
Argon gas is passed through in empty room, the flow of argon gas is controlled by flowmeter；When the stable gas pressure in vacuum chamber is in 10Pa-20Pa, open
Voltage is simultaneously added slowly to 450V-500V by power supply, is acted on by the bombardment of argon plasma, is made the integrally formed front end
The temperature of portion 11 and bending part 13 is maintained at 800-840 DEG C, at this point, under the bombardment effect of argon plasma, silver-colored strontium target
In Si and Ag element the surface alloying of the front end 11 and bending part 13 is deposited on by sputtering effect, form silver-colored strontium and close
Aurification layer, alloying time 1.5h-2h.
In step s3, the cladding pretreatment of layered double-hydroxide layer is carried out to the coil 2 by the following method:
S3-1. the coil 2 is put into reaction kettle, is 4wt%- with concentration under the conditions of 80 DEG C -100 DEG C of temperature
The sodium hydroxide of 6wt% carries out hydro-thermal reaction, reaction time 6h-8h；
S3-2. to the coil 2 by step S3-1 processing in the aqueous hydrochloric acid solution that concentration is 2wt%-4wt%,
With impregnate 180min-250min under normal temperature condition；
S3-3. the kayexalate and sodium chloride to the coil 2 by step S3-2 processing at 80 DEG C -90 DEG C
Mixed aqueous solution in impregnate 40min-60min, wherein the concentration of kayexalate and sodium chloride is respectively 2g/L-4g/L
And 6g/L-12g/L.
Obviously, above-described embodiment is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the present invention
In embodiment, those of ordinary skill in the art without creative efforts to these embodiments carry out it is various
Variation, modification, replacement and improvement, should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of preforming seal wire for the treatment of intravascular bifurcated lesions, it is characterised in that:
The core material (1) of the preforming seal wire includes front end (11), rear end (12) and bending part (13)；
The bending part (13) includes the first bending part (131) and the second bending part (132)；
First bending part (131) bends from the head of the front end (11) to the direction close to the rear end (12)；
Second bending part (132) is from the tail portion of first bending part (131) to far from the first bending part (131) axis
The direction of line is bent；
It is seamlessly transitted between first bending part (131) and front end (11), first bending part (131) and the second bending
Portion seamlessly transits between (132).
2. the preforming seal wire according to claim 1 for the treatment of intravascular bifurcated lesions, it is characterised in that: described the
Two bending parts (132) are bent along the radial direction of the core material (1).
3. the preforming seal wire according to claim 1 for the treatment of intravascular bifurcated lesions, it is characterised in that: before described
The outer peripheral edge of end (11) and bending part (13) is wound with coil (2).
4. the preforming seal wire according to claim 1 for the treatment of intravascular bifurcated lesions, it is characterised in that:
The front end (11) and bending part (13) are integrally formed；
The front end (11) and rear end (12) are interconnected and fixed using solder (4) by laser welding；
The rear end (12) has cylindrical structure；
The front end (11) has straight to one end far from the rear end (12) from one end close to the rear end (12)
The conical structure that diameter is gradually reduced.
5. the preforming seal wire according to claim 4 for the treatment of intravascular bifurcated lesions, it is characterised in that:
The front end (11) is equipped with stepped cylindrical boss (111)；
The rear end (12) is equipped with hollow circuit cylinder boss (121)；
After the stepped cylindrical boss (111) is partially protruded into the hollow circuit cylinder boss (121), using solder (4) by swashing
Photocoagulation connects the stepped cylindrical boss (111) and hollow circuit cylinder boss (121) fixation；
Or,
The front end (11) is equipped with hollow circuit cylinder boss (121)；
The rear end (12) is equipped with stepped cylindrical boss (111)；
After the stepped cylindrical boss (111) is partially protruded into the hollow circuit cylinder boss (121), using solder (4) by swashing
Photocoagulation connects the stepped cylindrical boss (111) and hollow circuit cylinder boss (121) fixation.
6. the preforming seal wire according to claim 3 for the treatment of intravascular bifurcated lesions, it is characterised in that:
The coil (2) includes the Inside coil (21) and external coil (22) of coaxial arrangement, and the external coil (22) surrounds
In the outside of the Inside coil (21)；
One end of the external coil (22) is welded to each other with the front end (11) by the first joint portion (31) and is connect, another
End, which is welded to each other by the second joint portion (32) with the tail end of second bending part (132), to be connect；
One end of the Inside coil (21) is welded to each other with the front end (11) by the first joint portion (31) and is connect, another
End, which is welded to each other by third joint portion (33) with the tail end of first bending part (131), to be connect；
The diameter of the external coil (22) is from one end close to first joint portion (31) to close to second joint portion
(32) one end is gradually increased；
The diameter of the Inside coil (21) is from one end close to first joint portion (31) to close to the third joint portion
(33) one end is gradually reduced.
7. the preforming seal wire according to claim 3 for the treatment of intravascular bifurcated lesions, it is characterised in that:
The core material (1) is made of any one in stainless steel material, nickel-titanium alloy material, gold, platinum, the coil
(2) it is made of any one in stainless steel material, nickel-titanium alloy material, gold, platinum；
The outer peripheral edge of the rear end (12) is coated with resin layer；
The outer peripheral edge of the front end (11) and bending part (13) is coated with silver-colored strontium alloy layer；
The outer peripheral edge of the coil (2) is coated with layered double-hydroxide layer.
8. a kind of preparation method of the preforming seal wire for the treatment of intravascular bifurcated lesions,
The preforming seal wire includes core material (1) and coil (2)；
The core material (1) and coil (2) are respectively adopted nickel-titanium alloy material and are made；
The core material (1) includes front end (11), rear end (12) and bending part (13)；The front end (11) and bending part
(13) outer peripheral edge is wound with coil (2)；
The coil (2) includes the Inside coil (21) and external coil (22) of coaxial arrangement, and the external coil (22) surrounds
In the outside of the Inside coil (21)；
It is characterized in that, the preforming seal wire is obtained by following steps:
S1. resin cladding pretreatment is carried out to the rear end (12)；
S2. metal sputter-deposition pretreatment is carried out to the integrally formed front end (11) and bending part (13)；
S3. the cladding pretreatment of layered double-hydroxide layer is carried out to the coil (2)；
S4. the front end (11) and rear end (12) are interconnected and fixed using solder (4) by laser welding；
S5. the Inside coil (21) is wound in the outer peripheral edge of the front end (11) and bending part (13), it will be described
One end of Inside coil (21) is welded to each other with the first joint portion (31), and by the other end and third of the Inside coil (21)
Joint portion (33) is welded to each other；S6., the external coil (22) is wound in the outside of the Inside coil (21), it will be described outer
One end of portion's coil (22) is welded to each other with the first joint portion (31), and the other end of the external coil (22) is connect with second
Conjunction portion (32) is welded to each other.
9. the preparation method of the preforming seal wire according to claim 8 for the treatment of intravascular bifurcated lesions, feature
It is:
The front end (11) is equipped with stepped cylindrical boss (111)；
The rear end (12) is equipped with hollow circuit cylinder boss (121)；
In step s 4, after the stepped cylindrical boss (111) being partially protruded into the hollow circuit cylinder boss (121), using weldering
Material (4) carries out Laser Welding along the external stepped cylindrical boss (111) that is exposed to for not extending into the hollow circuit cylinder boss (121)
It connects, the front end (11) is fixedly connected with rear end (12).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018109700144 | 2018-08-24 | ||
| CN201810970014 | 2018-08-24 |
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| CN109758661A true CN109758661A (en) | 2019-05-17 |
| CN109758661B CN109758661B (en) | 2021-11-23 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910047229.3A Active CN109758661B (en) | 2018-08-24 | 2019-01-17 | Preformed guide wire for treating bifurcation lesion in blood vessel |
| CN201920083573.3U Active CN210409214U (en) | 2018-08-24 | 2019-01-17 | Preformed guide wire for treating bifurcation lesion in blood vessel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920083573.3U Active CN210409214U (en) | 2018-08-24 | 2019-01-17 | Preformed guide wire for treating bifurcation lesion in blood vessel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114305570A (en) * | 2022-03-04 | 2022-04-12 | 上海微创心脉医疗科技(集团)股份有限公司 | Conveyor and stent system |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN109758661B (en) | 2021-11-23 |
| CN210409214U (en) | 2020-04-28 |
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