CN109758421A - A kind of indigo plant oxygen antiseptic ointment and preparation method thereof - Google Patents
A kind of indigo plant oxygen antiseptic ointment and preparation method thereof Download PDFInfo
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 83
- 239000001301 oxygen Substances 0.000 title claims abstract description 83
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 83
- 239000002674 ointment Substances 0.000 title claims abstract description 59
- 230000002421 anti-septic effect Effects 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 241001062009 Indigofera Species 0.000 title claims description 12
- 239000002994 raw material Substances 0.000 claims abstract description 17
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 16
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 15
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 15
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 15
- 239000008117 stearic acid Substances 0.000 claims abstract description 15
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- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 14
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- 238000004945 emulsification Methods 0.000 claims description 5
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- 241000233866 Fungi Species 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
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- 206010033733 Papule Diseases 0.000 description 2
- 206010034016 Paronychia Diseases 0.000 description 2
- 241000029132 Paronychia Species 0.000 description 2
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
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- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of blue oxygen antiseptic ointment and preparation method thereof, and the ointment includes that the following raw material is made: blue oxygen finish, vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin and atoleine.The processing that ointment prepared by the present invention passes through blue oxygen has no toxic and side effect to human body so that it has the function of stronger antibacterial, virus of going out, and noresidue has no drug resistance, and stability is good, can longer-term store, effective component will not be reduced；The preparation method of ointment of the present invention is simple, ozone and unsaturated fatty acid form relatively stable ozonide, increase ointment antibacterial and go out the effect of virus, and ointment prepared by the present invention can save 2 years or more at normal temperatures and pressures, stable effective ingredients, up to 3 years or more in the environment of 4 DEG C.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of indigo plant oxygen antiseptic ointment and preparation method thereof.
Background technique
Candidiasis is mainly by the Candida albicans of Mycotoruloides, gram Rou Shi candida albicans, Candida tropicalis, star candida albicans
And Gao Shi candida albicans causes, most of is all the morbidity when whole body or local resistance reduce, and the routes of infection can be endogenous
Or it is exogenous.Systemic infection mostly resists body after widely applying antibiotic, corticosteroid hormone, immunosuppressor etc.
Power weakens and causes, can also be due to iatrogenic pollute.Pyococcus infectious dermatosis, it is characterized in that papule, water occurs
Blister or warts, easy ulceration and form purulence scab, be contagious infection, sprawling rapidly, can be popular in children, and pathogen is most absolutely
Number is staphylococcus aureus, and minority is streptococcus, it is also possible to which the two mixed infection, contact dermatitis are that skin or sticking to mould connect
After touching certain articles, in the acute inflammation that contact site is occurred.Show as erythema, swelling, papule, blister, even bleb.Urine
Cloth dermatitis be due in excrement ammonia formed bacterium is decomposed on wet diaper urine and generate ammonia, due to ammonia stimulation generation dermatitis.
Eczema is that a kind of scytitis reaction with obvious exudation tendency, fash diversity as caused by a variety of internal and external factors are chronic
Phase then limits to and has infiltration and plumpness, and acute pruritus is easy to recur.Tinea of feet and hands is that pathogenic skin filamentous fungi is drawn at brothers position
The skin disease risen.The pathogen of tinea of feet and hands is substantially similar in China and all over the world, mainly there is Trichophyton rubrum, gypsum sample hair
Tinea bacterium, acrothesium floccosum, trichophyton meginii etc. cause.In recent years, candida albicans and other yeast-like fungus infected also repeatly
See not fresh.Paronychia has nail groove flush, swelling, Chang Yinqi first surrounding tissue inflammation, and secreting thick liquid property fester causes paronychia climing
Delay life.
Currently, the medicament of anti-bacteria and anti-virus is larger for human body side effect, residue is more, and it is most of can only play it is antibacterial
Effect, for virus effect it is unobvious, it is difficult to meet the needs of clinical treatment, and current compounded antibiotic preparation, mostly
The disadvantages of the effects of Chinese materia medica preparation, uncertain therapeutic efficacy cuts, is also easy to produce skin allergy and poor stability.
For these reasons, the present invention is specifically proposed.
Summary of the invention
In order to solve problem above of the existing technology, the present invention provides a kind of blue oxygen antiseptic ointment and its systems
Preparation Method, by the processing of blue oxygen in ointment of the invention, so that it has the function of stronger antibacterial, virus of going out, to human body
It has no toxic side effect, noresidue has no drug resistance, and stability is strong, long-term to store, stable effective ingredients.
To achieve the goals above, the present invention adopts the following technical scheme:
A kind of indigo plant oxygen antiseptic ointment, the ointment includes that the following raw material is made: blue oxygen finish, vaseline, tristearin
Acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin and atoleine.
Further, according to parts by weight, the ointment includes that the following raw material is made: blue oxygen finish 100-110 parts by weight,
Vaseline 20-30 parts by weight, stearic acid 35-46 parts by weight, azone 2-6 parts by weight, glycerin monostearate 32-40 parts by weight,
Polyvinylpyrrolidone 2-6 parts by weight, lanolin 3-7 parts by weight and atoleine 8-12 parts by weight.
Further, according to parts by weight, the ointment includes that the following raw material is made: blue 105.2 parts by weight of oxygen finish, all
25 parts by weight of intellectual circle, 40.5 parts by weight of stearic acid, 4 parts by weight of azone, 36 parts by weight of glycerin monostearate, polyvinylpyrrolidine
10 parts by weight of 4 parts by weight of ketone, 5 parts by weight of lanolin and atoleine.
Further, the blue oxygen finish the preparation method is as follows:
(1) vegetable oil 95-105 parts by weight, ethyl oleate 4-6 parts by weight and the smooth trioleate 3-5 weight of sorb are taken respectively
Part, it carries out uniformly mixed, obtains mixed liquor；
(2) emulsion reaction will be carried out in mixed liquor emulsion tank closed at less than 60 DEG C, is passed through from emulsification pot bottom smelly
Oxygen carries out Air Exposure, and ozone ventilatory capacity is 180-200g/h, aeration time 7-9h, obtains the blue oxygen finish.
Further, the vegetable oil is olive oil, soybean oil, sunflower oil, linseed oil or tea oil.
Further, ozone ventilatory capacity is 190g/h, aeration time 8h in step (2).
Ozone is also known as super oxygen, and three elemental oxygens are the allotrope of oxygen, molecular formula O3, molecular weight 48, normal
It is a kind of light blue gas with raw meat grass taste under normal temperature and pressure, under certain condition, the blue liquid of liquid can be formed, therefore also known as
For blue oxygen.The sterilization and disinfection function that blue oxygen is put with its height is widely used in health care, environmental protection, food sterilization, agricultural disappear
The processes such as poison, water disinfection.The characteristics of blue oxygen is that molecule is small, extremely unstable under room temperature normality, Yi Zihang resolve into oxygen and
Single oxygen atom has extremely strong oxidisability.Blue oxygen can be applied to kill pathogenic microorganism, be conducive to the health of the mankind.Blue oxygen
The mechanism of antiseptic is the cell membrane that can be directed through bacterium using the small feature of its molecule, acted on cell membrane outer membrane
Lipoprotein and film in lipopolysaccharides, destroy the membranous structure of thallus, make bacterium that penetrating sex distortion occur and dead.
It is anti-that with the ethylene linkage in vegetable oil and monounsaturated fatty acid molecule addition occurs for ozone of the invention under certain condition
It answers, generates metastable intermediate ozonide, it is then stearic with vaseline, stearic acid, azone, list in specific environment
Acid glyceride, polyvinylpyrrolidone, lanolin and atoleine homogeneous act on certain time, so that extremely active ozone point
Son forms relatively stable ozonide with unsaturated fatty acid, increases its antiseptic function.
The mechanism of blue oxygen antiseptic is the cell membrane that can be directed through bacterium using the small feature of its molecule, acted on
The lipopolysaccharides in lipoprotein and film on cell membrane outer membrane, destroys the membranous structure of thallus, make bacterium occur penetrating sex distortion and
It is dead.Blue oxygen sterilization and disinfection mechanism belongs to biochemical reaction process, and blue oxygen is other than above mechanism of action, into bacterium
Glucose oxidase necessary to oxidizing glucose in TAC is decomposed in direct oxidation in thallus, blocks TAC, and bacterium is made to lack life
ATP necessary to activity, meanwhile, blue oxygen directly acts on DNA, RNA, purine in Oxidative demage DNA, RNA molecule, pyrimidine
Structure terminates the breeding of bacterium.Blue oxygen makes virus not to the inhereditary material that the effect of virus is that direct oxidation destroys virus
Reproducible.The strong oxidizing property of blue oxygen, and its oxidation, without specificity, the alkenes compounds for having double bond to organic matter are equal
Affinity, for blue oxygen while antiseptic, the by-product of generation is oxygen and gaseous state hydrone, can be directly for histocyte
It utilizes, thus the antiseptic process noresidue of blue oxygen, it has no toxic side effect.
A kind of preparation method of the blue oxygen antiseptic ointment, includes the following steps:
(a) it is weighed respectively according to the weight of each raw material spare；
(b) by spare vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin, liquid
Body paraffin is respectively heated, then emulsifying；
(c) blue oxygen finish is added thereto and continues emulsifying, cooling, it is anti-to obtain the blue oxygen for filling and sealing
Bacterium is gone out malicious ointment.
Further, heating temperature is to 70-80 DEG C in step (b), emulsifying 1.5-2h.
Further, heating temperature is to 75 DEG C in step (b), emulsifying 105min.
Further, homogenizing time is 2-3h in step (c), and cooling temperature is to 45-55 DEG C.
Further, homogenizing time is 2.5h in step (c), and cooling temperature is to 50 DEG C.
Compared with prior art, the invention has the benefit that
(1) ointment prepared by the present invention passes through the processing of blue oxygen, so that it has the function of stronger antibacterial, virus of going out,
Sterilizing rate is high, and good antimicrobial effect has no toxic and side effect to human body, and noresidue has no drug resistance, long-term to store, stable effective ingredients；
(2) preparation method of ointment of the present invention is simple, and ozone and unsaturated fatty acid form relatively stable ozonide,
The antibacterial for increasing ointment is gone out the effect of virus, and ointment prepared by the present invention can save 2 years or more at normal temperatures and pressures, effectively
Stable components, up to 3 years or more in the environment of 4 DEG C.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
A kind of blue oxygen antiseptic ointment of the present embodiment, the ointment includes that the following raw material is made: blue oxygen finish
100kg, vaseline 20kg, stearic acid 35kg, azone 2kg, glycerin monostearate 32kg, polyvinylpyrrolidone 2kg, wool
Rouge 3kg and atoleine 8kg.
Wherein, blue oxygen finish the preparation method is as follows:
(1) vegetable oil 95kg, ethyl oleate 4kg and the smooth trioleate 3kg of sorb are taken respectively, carries out uniformly mixed, are obtained
Mixed liquor；
(2) emulsion reaction will be carried out in mixed liquor emulsion tank closed at less than 60 DEG C, is passed through from emulsification pot bottom smelly
Oxygen carries out Air Exposure, and ozone ventilatory capacity is 180g/h, aeration time 7h, obtains the blue oxygen finish.
The preparation method of the blue oxygen antiseptic ointment of the present embodiment includes the following steps:
(a) it is weighed respectively according to the weight of each raw material spare；
(b) by spare vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin, liquid
Body paraffin is respectively heated to 70 DEG C, and then 1.5h is reacted in emulsifying；
(c) blue oxygen finish is added thereto and continues emulsifying reaction 2h, be cooled to 45 DEG C, filling and sealing obtains
To the blue oxygen antiseptic ointment.
Embodiment 2
A kind of blue oxygen antiseptic ointment of the present embodiment, the ointment includes that the following raw material is made: blue oxygen finish
105.2kg, vaseline 25kg, stearic acid 40.5kg, azone 4kg, glycerin monostearate 36kg, polyvinylpyrrolidone 4kg,
Lanolin 5kg and atoleine 10kg.
Wherein, blue oxygen finish the preparation method is as follows:
(1) vegetable oil 100kg, ethyl oleate 5kg and the smooth trioleate 4kg of sorb are taken respectively, carries out uniformly mixed, are obtained
Mixed liquor；
(2) emulsion reaction will be carried out in mixed liquor emulsion tank closed at less than 60 DEG C, is passed through from emulsification pot bottom smelly
Oxygen carries out Air Exposure, and ozone ventilatory capacity is 190g/h, aeration time 8h, obtains the blue oxygen finish.
The preparation method of the blue oxygen antiseptic ointment of the present embodiment includes the following steps:
(a) it is weighed respectively according to the weight of each raw material spare；
(b) by spare vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin, liquid
Body paraffin is respectively heated to 75 DEG C, and then 105min is reacted in emulsifying；
(c) blue oxygen finish is added thereto and continues emulsifying reaction 2.5h, be cooled to 50 DEG C, filling and sealing,
Obtain the blue oxygen antiseptic ointment.
Embodiment 3
A kind of blue oxygen antiseptic ointment of the present embodiment, the ointment includes that the following raw material is made: blue oxygen finish
110kg, vaseline 30kg, stearic acid 46kg, azone 6kg, glycerin monostearate 40kg, polyvinylpyrrolidone 6kg, wool
Rouge 7kg and atoleine 12kg.
Wherein, blue oxygen finish the preparation method is as follows:
(1) vegetable oil 105kg, ethyl oleate 6kg and the smooth trioleate 5kg of sorb are taken respectively, carries out uniformly mixed, are obtained
Mixed liquor；
(2) emulsion reaction will be carried out in mixed liquor emulsion tank closed at less than 60 DEG C, is passed through from emulsification pot bottom smelly
Oxygen carries out Air Exposure, and ozone ventilatory capacity is 200g/h, aeration time 9h, obtains the blue oxygen finish.
The preparation method of the blue oxygen antiseptic ointment of the present embodiment includes the following steps:
(a) it is weighed respectively according to the weight of each raw material spare；
(b) by spare vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin, liquid
Body paraffin is respectively heated to 80 DEG C, and then 2h is reacted in emulsifying；
(c) blue oxygen finish is added thereto and continues emulsifying reaction 3h, be cooled to 55 DEG C, filling and sealing obtains
To the blue oxygen antiseptic ointment.
Comparative example 1
The raw material and preparation method and embodiment 2 of the antiseptic ointment of the present embodiment are all the same, and difference is not added
Blue oxygen finish.
Test example 1
Bacteriostatic test is carried out to embodiment 1-3 and comparative example 1 ointment prepared respectively, is measured minimum inhibitory concentration (MIC),
It the results are shown in Table 1.
The blue oxygen antiseptic ointment bacteriostatic test of table 1
As can be seen from the table, blue oxygen finish is not added with lower antibacterial dense in antiseptic ointment ratio prepared by the present invention
Degree, can prove that the antibacterial effect of ointment of the invention is more preferable.
Influence of the ozonation aerated time of test example 2 to sterilizing rate
Only change the aeration time in blue oxygen finish preparation process, other raw materials, ratio and preparation method with embodiment 2
Identical to carry out preparing antiseptic ointment, the ointment of preparation is measured influence of the aeration time difference to sterilizing rate, as a result sees
Table 2.
Influence of the ozonation aerated time of table 2 to sterilizing rate
As can be seen from the above table, the germicidal efficiency of the ointment prepared using aeration time of the invention is high, can be by large intestine
Bacillus, staphylococcus aureus, Candida albicans kill completely, this is because the shorter ozone molecule of aeration time and unsaturated lipid
Fat acid cannot still form stable ozonide, and germicidal efficiency reduces, as can be seen from the table when aeration time is more than 7 small
Escherichia coli, staphylococcus aureus, Candida albicans sterilizing rate are 100% afterwards, and the present inventor has found by a large number of experiments,
After aeration time is more than 9h, the quality of last blue oxygen finish obtained can be reduced, and viscosity is got higher, it has not been convenient to be used, and can be increased
Time and the cost for adding production cause the waste of resource, and comprehensive various aspects consider, select the aeration time of the application 7-9 hours
The ointment sterilizing rate with higher of lower preparation, and economical rationality, it is easy to use.
3 stability test of test example
Long-term stable experiment measurement is carried out to embodiment 1-3 and comparative example 1 ointment prepared respectively, and measures related object
The content of matter, test method: sample prepared by embodiment 1-3 and comparative example 1 is placed in climatic chamber, is 25 in temperature
± 2 DEG C, relative humidity is placed 36 months under conditions of being 65%, is stablized respectively at 0,3,6,9,12,18,24,36 month
Property test, the results are shown in Table 3.
The blue oxygen antiseptic ointment stability test of table 3
As can be seen from the above table, 1-3 of the embodiment of the present invention preparation sample at normal temperature, validity period can achieve 2 years with
On, and sample prepared by comparative example 1 is at 12 months, the content in relation to substance does not meet medication standard, illustrates this hair greater than 5
The ointment of bright preparation has preferable stability.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of indigo plant oxygen antiseptic ointment, which is characterized in that the ointment includes that the following raw material is made: blue oxygen finish, all
Intellectual circle, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin and atoleine.
2. indigo plant oxygen antiseptic ointment according to claim 1, which is characterized in that according to parts by weight, the ointment packets
It includes the following raw material to be made: blue oxygen finish 100-110 parts by weight, vaseline 20-30 parts by weight, stearic acid 35-46 parts by weight, azone
2-6 parts by weight, glycerin monostearate 32-40 parts by weight, polyvinylpyrrolidone 2-6 parts by weight, lanolin 3-7 parts by weight and
Atoleine 8-12 parts by weight.
3. indigo plant oxygen antiseptic ointment according to claim 2, which is characterized in that according to parts by weight, the ointment packets
It includes the following raw material to be made: blue 105.2 parts by weight of oxygen finish, 25 parts by weight of vaseline, 40.5 parts by weight of stearic acid, 4 weight of azone
Part, 36 parts by weight of glycerin monostearate, 10 weight of 4 parts by weight of polyvinylpyrrolidone, 5 parts by weight of lanolin and atoleine
Part.
4. blue oxygen antiseptic ointment according to claim 1 to 3, which is characterized in that the blue oxygen finish
The preparation method is as follows:
(1) vegetable oil 95-105 parts by weight, ethyl oleate 4-6 parts by weight and the smooth trioleate 3-5 parts by weight of sorb are taken respectively, into
Row is uniformly mixed, and obtains mixed liquor；
(2) emulsion reaction will be carried out in mixed liquor emulsion tank closed at less than 60 DEG C, from emulsification pot bottom be passed through ozone into
Row Air Exposure, ozone ventilatory capacity are 180-200g/h, aeration time 7-9h, obtain the blue oxygen finish.
5. indigo plant oxygen antiseptic ointment according to claim 4, which is characterized in that ozone ventilatory capacity is in step (2)
190g/h, aeration time 8h.
6. the preparation method of blue oxygen antiseptic ointment described in a kind of claim 1-5 any one, which is characterized in that including
Following steps:
(a) it is weighed respectively according to the weight of each raw material spare；
(b) by spare vaseline, stearic acid, azone, glycerin monostearate, polyvinylpyrrolidone, lanolin, liquid stone
Wax is respectively heated, then emulsifying；
(c) blue oxygen finish is added thereto and continues emulsifying, cooling, filling and sealing obtains the blue oxygen antibacterial and goes out
Malicious ointment.
7. the preparation method of indigo plant oxygen antiseptic ointment according to claim 6, which is characterized in that heating in step (b)
Temperature is to 70-80 DEG C, emulsifying 1.5-2h.
8. the preparation method of indigo plant oxygen antiseptic ointment according to claim 7, which is characterized in that heating in step (b)
Temperature is to 75 DEG C, emulsifying 105min.
9. the preparation method of indigo plant oxygen antiseptic ointment according to claim 6, which is characterized in that homogeneous in step (c)
Time is 2-3h, and cooling temperature is to 45-55 DEG C.
10. the preparation method of indigo plant oxygen antiseptic ointment according to claim 9, which is characterized in that homogeneous in step (c)
Time is 2.5h, and cooling temperature is to 50 DEG C.
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Cited By (2)
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| CN111012793A (en) * | 2019-12-30 | 2020-04-17 | 深圳仟枝生物科技股份有限公司 | Antibacterial and detoxicating gynecological gel and preparation method thereof |
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