CN109758376A - A kind of composition that skin is damaged that prevents the pollution of the environment - Google Patents
A kind of composition that skin is damaged that prevents the pollution of the environment Download PDFInfo
- Publication number
- CN109758376A CN109758376A CN201910253637.4A CN201910253637A CN109758376A CN 109758376 A CN109758376 A CN 109758376A CN 201910253637 A CN201910253637 A CN 201910253637A CN 109758376 A CN109758376 A CN 109758376A
- Authority
- CN
- China
- Prior art keywords
- skin
- pollution
- environment
- composition
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a kind of composition for preventing the pollution of the environment and damaging to skin, this composition includes poly (sodium aspartate), malachite extract, SEPITONIC M3, dipotassium glycyrrhizinate, serine, glycine, glutamic acid, alanine, auxiliary moisturizing ingredient；The present invention matches the detoxifying effect for closing dipotassium glycyrrhizinate by the absorption pollutant of SEPITONIC M3, reach Initiative Defense pollutant to the injury of skin, it is synergistic using serine, glycine, glutamic acid, alanine, lysine, arginine, threonine, proline and poly (sodium aspartate), improve the present invention to the heavy metal in air and pollutant absorption, flocculation, neutralize the effects of toxicity；And makes the present invention that there is apparent reparation cuticula, strengthen skin barrier function, avoid outside contamination from entering deep skin and damage.
Description
Technical field
The present invention relates to daily cosmetics fields, and in particular to a kind of combination damaged to skin that prevents the pollution of the environment
Object.
Background technique
The development of modern industry, the mankind's activities such as the acceleration of urbanization process, and fire coal, vehicle exhaust are to earth environment
Destruction, cause air quality sharply to decline, lead to air pollution.Term air pollution herein is including but not limited to motor-driven
Tail gas and industrial waste gas.Air pollution in this article refers to the gas pollutant of release and the particle of release.But it also wraps
Include the particle of rubber wheel friction.Particle related with air pollution may combine polycyclic aromatic hydrocarbons (PAH) but be not limited to
Rich in those of PAH.The carbon black pellet of printer release is also the air pollution problems inherent of indoor appearance.Another problem is in room
The interior air pollution generated with coal or firewood.Pollution sources complicated component in air, will affect health in addition to being directly sucked in
Outside, damage of the long-term contact to skin is also very big, and be mainly presented with: the colour of skin is obscure, skin quality is coarse, spot increases, barrier
Impaired, sensitivity takes place frequently, skin ageing, wrinkle are bred etc..In recent years, the harm of PM2.5 is paid close attention to by more and more crowds how
Daily pollution protection is carried out using skin care item and is repaired.
Since 2011, in Asia-Pacific individual's beauty care items " antipollution " declare grow beyond 40% every year；But all
It is to reduce injury of the pollutant to skin by way of improving skin function and repairing injury Passive Defence to realize, in
State invention CN107847413A discloses a kind of cosmetic composition containing ginger-root extract, and this composition contains selected from group
Including race CO2 extract, E/Z-2- benzyl indenes -5,6- dimethoxy -3,3- dimethylindane -1- ketone, Clary sage lactone, purple
The antipollution preparation of or mixtures thereof color black-eyed Susan juicing, content are enough the gene that (a) reduces or prevent air pollution from inducing
Expression reduces or prevents polycyclic aromatic hydrocarbons (PAH) induction or inducible gene expression, reduces or prevent air pollution induction or air
Derivable skin injury is polluted, but this composition is to have carried out quilt again after skin has been subjected to the damage of environmental contaminants
Dynamic remedies, repairs skin.
In conclusion research and development seem outstanding with a kind of cosmetics with the Initiative Defense environmental pollution before skin is received and injured
It is important.
Summary of the invention
The purpose of the present invention is to provide a kind of composition for preventing the pollution of the environment and damaging to skin, this compositions
Pollutant toxicity is actively eliminated, and the multi-efficiencies such as skin, moisturizing, whitening can be repaired.
In order to realize above scheme, the present invention the following technical schemes are provided:
A kind of composition damaged to skin that prevents the pollution of the environment, described prevent the pollution of the environment damage skin
Composition by weight percentage include following components:
Poly (sodium aspartate): 35-65%
Malachite extract: 3-6%
SEPITONIC M3:1-3%
Dipotassium glycyrrhizinate: 1-2%
Serine: 0.5-2%
Glycine: 0.5-1.5%
Glutamic acid: 0.5-1.5%
Alanine: 0.5-1.0%
Lysine: 0.1-1.0%
Arginine: 0.1-0.5%
Threonine: 0.1-0.5%
Proline: 0.05-0.2%
Assist moisturizing ingredient: surplus.
Preferably, the auxiliary moisturizing ingredient include: water, glycine betaine, Anjidew NL50, sorbose or sorbierite, polyglutamic acid,
One or more of glycerol.
Preferably, the auxiliary moisturizing ingredient is water, glycine betaine, Anjidew NL50, sorbose or sorbierite, water, glycine betaine, PCA
The weight of sodium, sorbose or sorbierite is 70:10:5:15.
Main component introduction of the present invention:
SEPITONIC M3: for the production of match BIC Corp, France, component INCI title is respectively as follows: magnesium aminosuccinate
(CAS:1187-91-3), zinc gluconate (CAS:4468-02-4), copper gluconate (CAS:527-09-3)；SEPITONIC M3 couple
Air pollutants have certain absorption and flocculation, can reduce air pollutants to the toxicity of skin, while also having good
Good Skin Cell energy supplement effect promotes self of skin metabolism and cell purification and toxin expelling etc..
Dipotassium glycyrrhizinate: INCI title: dipotassium glycyrrhizinate (CAS:68797-35-3).Dipotassium glycyrrhizinate is medically commonly used
In removing toxic substances, anti-inflammatory, in the present invention, dipotassium glycyrrhizinate has detoxicating, relieving inflammation, removing free radical, discharge toxin, anti-aging, antiallergic to repair
It is multiple and other effects.
Serine, glycine, glutamic acid, alanine, lysine, arginine, threonine, proline: its INCI title point
Not are as follows: serine (CAS:56-45-1), glycine (CAS:56-40-6), glutamic acid (CAS:56-86-0), alanine (CAS:
56-41-7), lysine (CAS:70-54-2), arginine (CAS:74-79-3), threonine (CAS:72-19-5), proline
(CAS:147-85-3)；It is human skin keratinocyte's layer isostructural aminoacid ingredient of NMF phase；Synergistic poly (sodium aspartate)
To in air heavy metal and pollutant absorption, flocculation, neutralize toxicity the effects of；Cuticula is repaired with apparent, strengthens skin
Skin barrier function avoids outside contamination from entering deep skin and damages.
Malachite extract: malachite is the carbonate mineral of cupric, and malachite originates in the oxidized zone of sulfide deposit of copper,
Often with other copper-bearing mineral symbiosis (chessy copper, vitreous copper, cuprite, native copper etc.).Belong to monoclinic system.Crystal habit Chang Chengzhu
Shape is needle-shaped, is usually in cryptocrystal stalactitic, bulk, cot shape, concretion forms and fibrous agrregate.Tool concentric layered shell polysaccharide, fiber are put
Shape structure is penetrated, malachite extract has the effect of removing free radical, removing toxic substances, moisturizing water lock.
The invention has the advantages that:
1, the present invention matches the detoxifying effect for closing dipotassium glycyrrhizinate using the absorption pollutant of SEPITONIC M3, reaches main
Injury of the dynamic defence pollutant to skin.
2, serine in the present invention, glycine, glutamic acid, alanine, lysine, arginine, threonine, proline and poly-
The works such as NaAsp is synergistic, and the raising heavy metal and pollutant of the invention in air adsorbs, flocculates, neutralizes toxicity
With；And makes the present invention that there is apparent reparation cuticula, strengthen skin barrier function, outside contamination is avoided to enter deep skin
It damages.
3, present invention addition malachite extract, so that the present invention has the effect of removing free radical, removing toxic substances, moisturizing, with
Initiative Defense pollutant of the present invention reaches the injury of skin and the cooperation of a variety of amino acid to be caused to hurt in defence pollutant to skin
There are the multiple efficacies such as moisturizing, reparation, antiallergic, whitening while evil, meet the market demand.
Detailed description of the invention
Fig. 1 is erythema average change value histogram in the specific embodiment of the invention；
Fig. 2 is foxiness average change value histogram in the specific embodiment of the invention；
Fig. 3 is wrinkle average change value histogram in the specific embodiment of the invention；
Fig. 4 is pore average change value histogram in the specific embodiment of the invention；
Fig. 5 is moisture content average change value histogram in the specific embodiment of the invention；
Fig. 6 is transepidermal water loss rate average change value changing value histogram in the specific embodiment of the invention；
Fig. 7 is frictional force average change value changing value histogram in the specific embodiment of the invention；
Fig. 8 is oil average change value changing value histogram in the specific embodiment of the invention；
Fig. 9 is that chick chorioallantoic membrane reads average change value histogram in the specific embodiment of the invention.
Specific embodiment
Below with reference to embodiment and test example, the present invention is further elaborated.
One, embodiment
Embodiment 1
Formula one,
Poly (sodium aspartate): 35%, malachite extract: 3%, SEPITONIC M3:1%, dipotassium glycyrrhizinate: 1%, silk
Propylhomoserin: 0.5%, glycine: 0.5%, glutamic acid: 0.5%, alanine: 0.5%, lysine: 0.1%, arginine: 0.1%,
Threonine: 0.1%, proline: 0.05%, auxiliary element: 57.65%.
Process:
1, first ultrapure water (0.5 μ s/cm of conductivity <) is added in stainless steel agitated kettle, and is heated to 80-85 DEG C, kept the temperature
Sterilization was cooled to 40-50 DEG C after 30 minutes, other auxiliary elements are added in pot in proportion, stirred uniform；Formula rate is pressed again
Add dipotassium glycyrrhizinate, stir at low speed (revolving speed: 20-30 revs/min) it is transparent to being completely dissolved, be kept stirring speed (revolving speed:
40-60 revs/min) it stirs after ten minutes, malachite extract, SEPITONIC M3, a variety of amino acid etc. are sequentially added, is stirred
After ten minutes, it is placed in stainless steel storage tank with the filter-cloth filtering discharging of 500 mesh, sample detection, according to " cosmetics safety technology is advised
Model " (2015 editions), the standards such as QB/T 2660 are detected, filling, sealing are carried out after qualified, packaging, is packaged, examines storage.
Application method: 2-10% additive amount by weight is added in skin care item recipe ingredient.
Embodiment 2
Formula two,
Poly (sodium aspartate): 45%, malachite extract: 4%, SEPITONIC M3:1.5%, dipotassium glycyrrhizinate:
1.5%, serine: 0.6%, glycine: 0.6%, glutamic acid: 0.6%, alanine: 0.6%, lysine: 0.2%, smart ammonia
Acid: 0.2%, threonine: 0.2%, proline: 0.2%, auxiliary element: 44.8%.
Process, application method: with formula one
Embodiment 3
Formula three,
Poly (sodium aspartate): 55%, malachite extract: 4%, SEPITONIC M3:2%, dipotassium glycyrrhizinate: 1.8%,
Serine: 0.8%, glycine: 0.9%, glutamic acid: 1.0%, alanine: 0.7%, lysine: 0.25%, arginine:
0.3%, threonine: 0.3%, proline: 0.3%, auxiliary element: 32.65%.
Process, application method: with formula one
Embodiment 4
Formula four,
Poly (sodium aspartate): 65%, malachite extract: 5%, SEPITONIC M3:2.5%, dipotassium glycyrrhizinate:
1.9%, serine: 1.2%, glycine: 1.0%, glutamic acid: 1.0%, alanine: 1.0%, lysine: 1.0%, smart ammonia
Acid: 0.4%, threonine: 0.4%, proline: 0.4%, auxiliary element: 19.6%.
Process, application method: with formula one
Embodiment 5
Formula five,
Poly (sodium aspartate): 65%, malachite extract: 6%, SEPITONIC M3:3%, dipotassium glycyrrhizinate: 2%, silk
Propylhomoserin: 2%, it glycine: 1.5%, glutamic acid: 1.5%, alanine: 1.0%, lysine: 1.0%, arginine: 0.5%, revives
Propylhomoserin: 0.5%, proline: 0.2%, auxiliary element: 44.8%.
Process, application method: with formula one
Two, test example
Test example 1: comparative test product a, by the market certain declare the Essence with resistant to pollution famous brand name；To having a competition
It tests product b, be added in identical Essence matrix according to 3% additive amount respectively with the composition of five formulas of above-described embodiment,
The sample of production is made；Comparative test product c, placebo (with above-mentioned Essence matrix) are not added with carrying out pair for antipollution composition
Before and after use: the project datas such as VISA tester, CK tester；
Test method:
1, test environment conditions
Environment on probation: the unshielded urban work living environment of long-term outdoor (having the adverse circumstances such as dust, high temperature, tail gas)
Test environment temperature: 20-22 DEG C, humidity: 40%-60%, and carry out real-time dynamic monitoring
2, volunteer's number
56 people of effective volunteer
3, volunteer's condition
Age (male to female ratio: 1:1) between 18-45 years old, daily staff (the food market person of selling, express delivery outdoors
Member, security personnel, take-away person, cleaner), no serious systemic disease patient, without immune deficiency or autoimmune disease person, no active
Anaphylactia person did not receive skin treating without the highly sensitive person of constitution, recipient site, does not use hormone within nearly one month
Class drug and immunosuppressor, it is three months nearly in recipient site do not participate in other clinical test persons.
4, operating procedure
It first checks the compliance of volunteer, then volunteer's stochastic averagina is divided into 7 groups, every group is received a kind of essence at random
Liquid；It after nursing unit is dry with the facial skin wiping of standard facial cleanser cleaning, is waited for peacefully 20 minutes in constant temperature and humidity waiting room within first day
More than, skin data (erythema, foxiness, wrinkle, pore, moisture content, transepidermal water loss rate, frictional force, oil are successively acquired with VISA, CK
Point etc.), then wait for peacefully every the data of acquisition in 30 minutes, it acquires in total three times.
Then the Essence for using distribution by requirement after morning and evening face cleaning once a day, was used continuously for 8 weeks, often
A data are acquired over 4 days and get test Essence, and the method for acquiring data is same as above, and the time is afternoon.Experimental result is seen below
Table 1
Table 1
Seen from table 1, it is the skin for taking antipollution measure, is chronically at open air, the erythema index for representing inflammation is bright
Aobvious to increase, pore index, the frictional force for representing smoothness are significantly raised, represent the foxiness index of the colour of skin uniformity also on
It rises, so air quality difference is to damage to skin, while the present composition is added in Essence with obvious fast
To skin damage problem, the product than declaring to have effects that antipollution in the market is more effective for the improvement environmental pollution of speed；
Test example 2:
Test environment
Temperature: 20-28 DEG C, humidity: 40%-80%, and carry out real-time dynamic monitoring
Contrast sample
A, by the market certain declare the Essence with resistant to pollution famous brand name；
B, comparative test product b, with the compositions of five of above-described embodiment formulas phase is added according to 3% additive amount respectively
With in Essence matrix, the sample of production is made；
C, comparative test product c, placebo (with above-mentioned Essence matrix)
Operating procedure
1, every kind of sample of above-mentioned a b c is taken into 1 10 grams of Material, carries out chick embryo allantois embrane method test (skin care item respectively
The mild-natured method of universal safety)；
2, by above-mentioned a b every kind of sample of c take 1 10 grams of Material, the heavy metal that same concentrations are added dropwise thereto respectively is molten
(heavy metal concentration is not less than liquid respectively: lead: 20ppm, mercury 2ppm, arsenic 5ppm, cadmium 10ppm, and the heavy metal solution used is country
Iron and Steel Research Geueral Institute, steel material test center production national standard solution), stir respectively it is uniform after, with chick embryo allantois embrane method
Test；
3, each sample chick embryo allantois embrane method test data of heavy metal will be added to subtract the corresponding sample for not aggravating metal
Product chick chorioallantoic membrane data, experimental data see the table below 2.
Table 2
As can be seen from Table 2, heavy metal has an apparent injury to skin, the present invention can be substantially reduced heavy metal pollution to skin
Extent of injury；And it is significantly better than current commercial product；
Above-described embodiment is only currently preferred case study on implementation, cannot limit present invention model claimed with this
Enclose, any unsubstantiality that those skilled in the art is done on the basis of the present invention and replacement belong to the present invention more want
Seek the range of protection.
Claims (3)
1. a kind of composition damaged to skin that prevents the pollution of the environment, which is characterized in that described to prevent the pollution of the environment to skin
The composition that skin damages includes following components by weight percentage:
Poly (sodium aspartate): 35-65%
Malachite extract: 3-6%
SEPITONIC M3:1-3%
Dipotassium glycyrrhizinate: 1-2%
Serine: 0.5-2%
Glycine: 0.5-1.5%
Glutamic acid: 0.5-1.5%
Alanine: 0.5-1.0%
Lysine: 0.1-1.0%
Arginine: 0.1-0.5%
Threonine: 0.1-0.5%
Proline: 0.05-0.2%
Assist moisturizing ingredient: surplus.
2. the composition according to claim 1 that damaged to skin that prevents the pollution of the environment, which is characterized in that described auxiliary
Help moisturizing ingredient include: one or both of water, glycine betaine, Anjidew NL50, sorbose or sorbierite, polyglutamic acid, glycerol with
On.
3. the composition according to claim 2 that damaged to skin that prevents the pollution of the environment, which is characterized in that described auxiliary
Helping moisturizing ingredient is water, glycine betaine, Anjidew NL50, sorbose or sorbierite, water, glycine betaine, Anjidew NL50, sorbose or sorbierite weight
Amount is 70:10:5:15.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910253637.4A CN109758376A (en) | 2019-03-30 | 2019-03-30 | A kind of composition that skin is damaged that prevents the pollution of the environment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910253637.4A CN109758376A (en) | 2019-03-30 | 2019-03-30 | A kind of composition that skin is damaged that prevents the pollution of the environment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109758376A true CN109758376A (en) | 2019-05-17 |
Family
ID=66460253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910253637.4A Pending CN109758376A (en) | 2019-03-30 | 2019-03-30 | A kind of composition that skin is damaged that prevents the pollution of the environment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109758376A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043660A (en) * | 2020-10-19 | 2020-12-08 | 湖南金昌生物技术有限公司 | Green and environment-friendly oil-control whitening acne-removing freckle-removing facial cleaning powder and preparation method thereof |
| CN112972360A (en) * | 2021-03-03 | 2021-06-18 | 上海好肌茵生物科技有限公司 | Sensitive repairing composition and preparation method and application thereof |
| EP4282512A1 (en) * | 2022-05-27 | 2023-11-29 | Neutec Chemie GmbH | Air pollution neutralizer with potential fragrance function to improve room air |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825362A (en) * | 2015-05-11 | 2015-08-12 | 广州九美仟惠生物科技有限公司 | Whitening and freckle removing cream containing Bacopa anti-sensitive repair factor |
| CN104958222A (en) * | 2015-07-20 | 2015-10-07 | 广州三十六度伴生物科技有限公司 | Glacier solid water |
| CN107174548A (en) * | 2017-06-20 | 2017-09-19 | 广东盛美化妆品有限公司 | A kind of micro emulsion spraying of the fat of fruit containing Butyrospermum parkii and preparation method thereof |
| US20180177703A1 (en) * | 2015-06-25 | 2018-06-28 | N.V. Perricone Llc | Niacinamide Mononucleotide Formulations For Skin Aging |
-
2019
- 2019-03-30 CN CN201910253637.4A patent/CN109758376A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825362A (en) * | 2015-05-11 | 2015-08-12 | 广州九美仟惠生物科技有限公司 | Whitening and freckle removing cream containing Bacopa anti-sensitive repair factor |
| US20180177703A1 (en) * | 2015-06-25 | 2018-06-28 | N.V. Perricone Llc | Niacinamide Mononucleotide Formulations For Skin Aging |
| CN104958222A (en) * | 2015-07-20 | 2015-10-07 | 广州三十六度伴生物科技有限公司 | Glacier solid water |
| CN107174548A (en) * | 2017-06-20 | 2017-09-19 | 广东盛美化妆品有限公司 | A kind of micro emulsion spraying of the fat of fruit containing Butyrospermum parkii and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘卉编著: "《人物形象设计系列 化妆品应用基础》", 31 January 2011 * |
| 沈翠云等: "聚天冬氨酸钠在护肤品中的应用", 《日用化学工业》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043660A (en) * | 2020-10-19 | 2020-12-08 | 湖南金昌生物技术有限公司 | Green and environment-friendly oil-control whitening acne-removing freckle-removing facial cleaning powder and preparation method thereof |
| CN112972360A (en) * | 2021-03-03 | 2021-06-18 | 上海好肌茵生物科技有限公司 | Sensitive repairing composition and preparation method and application thereof |
| CN112972360B (en) * | 2021-03-03 | 2023-04-07 | 上海好肌茵生物科技有限公司 | Sensitive repairing composition and preparation method and application thereof |
| EP4282512A1 (en) * | 2022-05-27 | 2023-11-29 | Neutec Chemie GmbH | Air pollution neutralizer with potential fragrance function to improve room air |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109758376A (en) | A kind of composition that skin is damaged that prevents the pollution of the environment | |
| Hayakumo et al. | Effects of ozone nano-bubble water on periodontopathic bacteria and oral cells-in vitro studies | |
| Oliver | Lead poisoning | |
| Ramlogan | Environment and human health: A threat to all | |
| CN106310326A (en) | Air freshener and preparation method thereof | |
| Khalaf et al. | Ameliorative effect of zinc oxide nanoparticles against dermal toxicity induced by lead oxide in rats | |
| Hackley et al. | Air pollution: impact on maternal and perinatal health | |
| JP2008007451A (en) | Sterilizer | |
| CN101954107B (en) | Solid aromatic sleep aid and preparation method thereof | |
| ES2904626T3 (en) | Cosmetic compositions for protection against air pollutants | |
| Alexander et al. | Green synthesis of cerium nanoparticles using Hibiscus rosasinesis extract and evaluation of their antimicrobial activity and photocatalytic activity | |
| CN103493850A (en) | Special air antiseptic for air cleaner | |
| Ita et al. | Vitamin C or E supplementation ameliorates Nigerian Bonny light crude oil-induced erythrocyte haemolysis in male Wistar rats | |
| KR101043806B1 (en) | A functional salt and a method of preparing the same | |
| CN107998065A (en) | A kind of skin toxin expelling complexing frost and its production method | |
| KR100439124B1 (en) | Manufacturing process of Rock Composition for Magma Q water having antivirus and sterilization | |
| Vagin et al. | Development of a radioprotective drug based on substances of plant, microbial, zoogenic and inorganic origin | |
| Walser III | Hidden dangers? An investigation of volcanic and environmental impacts on human health and life in historical Iceland | |
| Calhelha et al. | Bioactive properties of pollen samples collected in the Northeast of Portugal | |
| Jeffet et al. | Effect of mucoadhesive agent HEC on herbal extracts retention and VSC producing bacteria reduction in an experimental oral biofilm | |
| CN101653498B (en) | Nano-herb micro-pills for removing eel poisoning and preparation method thereof | |
| Adepoju-Bello et al. | Phytochemical screening, antioxidant activity, antimicrobial activity and heavy metal quantification of Chrysophyllum albidum fruit extract (sapotaceae) | |
| Popovych et al. | THE CONTENT OF ZINC AND CADMIUM IN BLOOD AND ORAL FLUID IN GENERALIZED PERIODONTITIS IN PEOPLE EXPOSED TO ADVERSE ENVIRONMENTAL FACTORS | |
| AU2015101911A4 (en) | Uses of multipolar microkinetic drinking water in preparing drink, healthcare product or medicament used for weight reduction | |
| Georgieva et al. | Hygienic assessment of the water reservoirs" Studena"," Bistrica" and" Pchelina", based on performed hydrobiological analyzes and determination of some cyanotoxins. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190517 |
|
| RJ01 | Rejection of invention patent application after publication |