CN109757509A - Environmentally friendly double third ring worm ester nanometer pulvis of one kind and preparation method thereof - Google Patents
Environmentally friendly double third ring worm ester nanometer pulvis of one kind and preparation method thereof Download PDFInfo
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- CN109757509A CN109757509A CN201811632002.7A CN201811632002A CN109757509A CN 109757509 A CN109757509 A CN 109757509A CN 201811632002 A CN201811632002 A CN 201811632002A CN 109757509 A CN109757509 A CN 109757509A
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Abstract
The invention belongs to technical field of pesticide, especially a kind of environmentally friendly double third ring worm ester nanometer pulvis, including active components A, the active components A is double third ring worm esters, further includes solvent 9-26wt%, small molecule auxiliary agent 10-25wt%, pluronic polymer less than 8-16wt% and dispersing agent water 32-56wt%.After above-mentioned formula and technique, double third ring worm ester nanometer pulvis nanoscales prepared by the present invention, the pesticide of same quality, the area of more pesticide granule amounts, bigger surface area and target contact is just wider, the drug effect of performance is just higher, it can be used for aviation plant protection special agent, do not generate precipitating, spray head will not be blocked；Environmental-friendly auxiliary agent is selected, does not select high poison solvent and auxiliary agent, it is more efficient, more environmentally friendly and safer, it changes in the past only with efficient, less toxic for preferred state, it is desirable that medicament is environmentally safe as the most important condition.
Description
Technical field
The invention belongs to technical field of pesticide, especially a kind of environmentally friendly double third ring worm ester nanometer pulvis and its preparation
Method.
Background technique
Double third ring worm esters are the novel botanical pesticide of Japan's exploitation, English name afidopyropen, molecular formula
C33H39NO9.Double third ring worm esters have unique structure and completely new mechanism of action, pass through interference insect vanilloid receptor channel
The regulation of compound and play a role, so that the feeding of interference insect and other behaviors, it is hungry dead to eventually lead to pest.With it is existing
There is insecticide no interactions resistance, can be used for foliar spray and soil treatment, to the aphid on melon dish, fruit tree, grain work and flowers, powder
Lice, plant hopper, leafhopper and coccid all have very high virulence.
108849962 A of Chinese invention patent application CN discloses a kind of desinsection containing double third ring worm esters and Buprofezin
Agent composition, Zhong Yishuan the third ring worm ester and Buprofezin are insecticide and its application of main active compounding, and it is multiple to belong to pesticide
With technical field.The weight fraction ratio of double third ring worm esters and Buprofezin is 10: 1~1: 20, which makees with synergy
With obvious, quick-acting is good, duration length, low toxicity, low-residual, it is esy to use, safe and reliable the advantages that, can effectively delay pest
Drug resistance generates, and has larger application value in agricultural production.
Summary of the invention
The technical problem to be solved by the invention is to provide a kind of Environmental security and efficient double third ring worm ester nanometer pulvis
And preparation method thereof.
In order to solve the above technical problems, the environmentally friendly double third ring worm ester nanometer pulvis of one kind of the invention, including work
Property ingredient A, the active components A is double third ring worm esters, further includes solvent 9-26wt%, small molecule auxiliary agent 10-25wt%, high score
Sub- auxiliary agent is less than 8-16wt% and dispersing agent water 32-56wt%.
Preferably, the solvent selects one or both of acetone or cyclohexanone.
Preferably, the biodegradable small molecule auxiliary agent of the small molecule selection of auxiliary, including anionic surface activity
Agent or nonionic surface active agent.
Preferably, the ionic surfactant includes carboxylate, the sulphur for the straight chained alkyl that different carbon atom numbers are constituted
Hydrochlorate, sulfate, the nonionic surface active agent include straight chained alkyl ether, the ester, amide that different carbon atom numbers are constituted
Polyoxyethylene ether, at least two mixture in the biodegradable above-mentioned surfactant of small molecule selection of auxiliary,
The HLB value position 12-15 of the small molecule auxiliary agent, dosage 10-25%.
Preferably, the pluronic polymer selects water soluble polymer auxiliary agent, including water-soluble macromolecule and its spreads out
Biology or synthesis macromolecule.
Preferably, the water-soluble macromolecule and its derivative include dextrin, cyclodextrin, water soluble starch, oxidation
Starch, carboxymethyl starch, modified starch, carboxymethyl cellulose, hydroxyethyl hydroxypropyl base cellulose；Carboxymethyl chitosan, modified melon
That glue, Tea Saponin, the synthesis macromolecule select polyvinyl alcohol, Sodium Polyacrylate, polyacrylamide, polypyrrole alkanone, polyphenyl
Ethylene-maleic acid sodium, the water soluble polymer selection of auxiliary are one such or several.
The invention also discloses a kind of environmentally friendly double third ring worm ester nanometer pulvis preparation methods, the preparation method packets
Include following steps,
(1) a certain amount of pesticide original medicine is dissolved in solvent or in the mixed solvent, be configured to close to saturated solution, referred to as component
A；
(2) a certain amount of pluronic polymer is dissolved in water, stirs, is configured to certain density aqueous solution, referred to as group
Divide B；
(3) a certain amount of small molecule auxiliary agent is added in component B, stirring is configured to composite assistant solution, referred to as component C；
(4) under agitation, it by the pesticide solution, that is, component A, instills in composite assistant solution, that is, component C, control is added dropwise
Speed makes it not generate precipitating, and keeps solution transparent, becomes component D；
(5) component D is spray-dried, obtains target product.
Preferably, the pesticide original medicine in the step (1) includes active components A, and the active components A is double third ring worms
Ester.
Preferably, the pluronic polymer in the step (2) be selected from dextrin, cyclodextrin, water soluble starch, oxidized starch,
Carboxymethyl starch, modified starch, carboxymethyl cellulose, hydroxyethyl hydroxypropyl base cellulose, carboxymethyl chitosan, modified guar,
Tea Saponin, the synthesis macromolecule select polyvinyl alcohol, Sodium Polyacrylate, polyacrylamide, polypyrrole alkanone, polystyrene-
One or more of maleic acid sodium.
Preferably, the small molecule auxiliary agent in the step (3) is selected from carboxylate, sulfonate, sulfate, different carbon atom numbers
The straight chained alkyl ether of composition, ester, amide polyoxyethylene ether at least two, the HLB value position 12- of the small molecule auxiliary agent
15, dosage 10-25%.
After above-mentioned formula and technique, double third ring worm ester nanometer pulvis nanoscales prepared by the present invention, same quality
The area of pesticide, more pesticide granule amounts, bigger surface area and target contact is just wider, and the drug effect of performance is just higher,
It can be used for aviation plant protection special agent, do not generate precipitating, spray head will not be blocked；Environmental-friendly auxiliary agent is selected, height is not selected
Malicious solvent (benzene, toluene, dimethylbenzene, methanol) and auxiliary agent (nonylphenol polyoxyethylene ether), it is more efficient, more environmentally friendly and safer, change
Only with efficient, less toxic into preferred state before having become, it is desirable that medicament is environmentally safe as the most important condition.
Specific embodiment
The following examples can make those skilled in the art that the present invention be more fully understood, but these embodiments are not
Limiting the scope of the invention." one embodiment " or " embodiment " referred to herein, which refers to, may be included in the present invention at least
A particular feature, structure, or characteristic in one implementation.In the present specification different places occur " in one embodiment
In " the same embodiment not is referred both to, nor the individual or selective embodiment mutually exclusive with other embodiments.
Wt% in the present invention refers to that each raw material accounts for the mass percent of total mass of raw material.
Embodiment 1
A kind of environmentally friendly double third ring worm ester nanometer pulvis, including active components A, the active components A are double third rings
Worm ester, active constituent 9wt% further include solvent 9wt%, small molecule auxiliary agent 10wt%, pluronic polymer 16wt%, dispersing agent water
56wt%.
Wherein, solvent selects acetone.
Wherein, the biodegradable small molecule auxiliary agent of small molecule selection of auxiliary, including anionic surfactant or non-
Ionic surfactant, ionic surfactant include carboxylate, the sulfonic acid for the straight chained alkyl that different carbon atom numbers are constituted
Salt, nonionic surface active agent includes the polyoxyethylene ether of the straight chained alkyl ether of different carbon atom numbers compositions, ester, amide, small
The HLB value position 12-15 of molecule auxiliary agent, dosage 10%.
Wherein, pluronic polymer selects water soluble polymer auxiliary agent, including water-soluble macromolecule and its derivative, day
Right water soluble polymer and its derivative select dextrin, cyclodextrin and water soluble starch.
Environmentally friendly double third ring worm ester nanometer pulvis preparation methods in the present embodiment include the following steps,
(1) pesticide original medicine is dissolved in solvent or in the mixed solvent, be configured to close to saturated solution (pesticide active ingredient
Content is by the small content in final nano-powder preparation), referred to as component A；
(2) pluronic polymer is dissolved in water, stirs, is configured to certain density aqueous solution, referred to as component B；
(3) small molecule auxiliary agent is added in component B, stirring is configured to composite assistant solution, referred to as component C；
(4) under agitation, it by the pesticide solution, that is, component A, instills in composite assistant solution, that is, component C, control is added dropwise
Speed makes it not generate precipitating, and keeps solution transparent, becomes component D；
(5) component D is spray-dried, obtains target product.
Embodiment 2
A kind of environmentally friendly double third ring worm ester nanometer pulvis, including active components A, the active components A are double third rings
The mass fraction of worm ester, active constituent is 9wt%, further includes solvent 26wt%, small molecule auxiliary agent 25wt%, pluronic polymer
8wt% and dispersing agent water 32wt%.
Wherein, solvent selects cyclohexanone.
Wherein, the biodegradable small molecule auxiliary agent of small molecule selection of auxiliary, including anionic surfactant, ion
Type surfactant includes carboxylate, sulfonate, the sulfate for the straight chained alkyl that different carbon atom numbers are constituted, small molecule auxiliary agent
HLB value position 12-15, dosage 25%.
Wherein, pluronic polymer selects water soluble polymer auxiliary agent, including water-soluble macromolecule and its derivative, day
Right water soluble polymer and its derivative include carboxymethyl chitosan, modified guar, Tea Saponin.
Environmentally friendly double third ring worm ester nanometer pulvis preparation methods in the present embodiment include the following steps,
(1) pesticide original medicine is dissolved in solvent or in the mixed solvent, be configured to close to saturated solution (pesticide active ingredient
Content is by the small content in final nano-powder preparation), referred to as component A；
(2) pluronic polymer is dissolved in water, stirs, is configured to certain density aqueous solution, referred to as component B；
(3) small molecule auxiliary agent is added in component B, stirring is configured to composite assistant solution, referred to as component C；
(4) under agitation, it by the pesticide solution, that is, component A, instills in composite assistant solution, that is, component C, control is added dropwise
Speed makes it not generate precipitating, and keeps solution transparent, becomes component D；
(5) component D is spray-dried, obtains target product.
Embodiment 3
A kind of environmentally friendly double third ring worm ester nanometer pulvis, including active components A, the active components A are double third rings
Worm ester, active constituent account for 10wt%, further include solvent 20wt%, small molecule auxiliary agent 20wt%, pluronic polymer 10wt% and point
Powder water 40wt%.
Wherein, solvent selects acetone and cyclohexanone to mix according to volume ratio 1: 1.
Wherein, the biodegradable small molecule auxiliary agent of small molecule selection of auxiliary, including nonionic surface active agent, it is non-from
Subtype surfactant includes the polyoxyethylene ether of the straight chained alkyl ether of different carbon atom numbers compositions, ester, amide, small molecule auxiliary agent
HLB value position 12-15, dosage 10-25%.
Wherein, pluronic polymer selects water soluble polymer auxiliary agent, including synthesis macromolecule, and synthesis macromolecule selects poly- second
Enol, Sodium Polyacrylate, polyacrylamide, polypyrrole alkanone, polystyrene-maleic acid sodium.
Environmentally friendly double third ring worm ester nanometer pulvis preparation methods in the present embodiment include the following steps,
(1) pesticide original medicine is dissolved in solvent or in the mixed solvent, be configured to close to saturated solution (pesticide active ingredient
Content is by the small content in final nano-powder preparation), referred to as component A；
(2) pluronic polymer is dissolved in water, stirs, is configured to certain density aqueous solution, referred to as component B；
(3) small molecule auxiliary agent is added in component B, stirring is configured to composite assistant solution, referred to as component C；
(4) under agitation, it by the pesticide solution, that is, component A, instills in composite assistant solution, that is, component C, control is added dropwise
Speed makes it not generate precipitating, and keeps solution transparent, becomes component D；
(5) component D is spray-dried, obtains target product.
The above description is merely a specific embodiment, and scope of protection of the present invention is not limited thereto, any ripe
Know those skilled in the art in the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of, should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope that protection scope of the present invention should be defined with claim
Subject to.
Claims (10)
1. a kind of environmentally friendly double third ring worm ester nanometer pulvis, it is characterised in that: including active components A, the active components A
For double third ring worm esters, further include solvent 9-26wt%, small molecule auxiliary agent 10-25wt%, pluronic polymer be less than 8-16wt% and
Dispersing agent water 32-56wt%.
2. the environmentally friendly double third ring worm ester nanometer pulvis of one kind according to claim 1, it is characterised in that: the solvent
Select one or both of acetone or cyclohexanone.
3. the environmentally friendly double third ring worm ester nanometer pulvis of one kind according to claim 1, it is characterised in that: described small point
The biodegradable small molecule auxiliary agent of sub- selection of auxiliary, including anionic surfactant or nonionic surface active agent.
4. the environmentally friendly double third ring worm ester nanometer pulvis of one kind according to claim 3, it is characterised in that: the ion
Type surfactant includes carboxylate, sulfonate, the sulfate for the straight chained alkyl that different carbon atom numbers are constituted, described non-ionic
Surfactant includes the polyoxyethylene ether of the straight chained alkyl ether of different carbon atom numbers compositions, ester, amide, described biodegradable
The above-mentioned surfactant of small molecule selection of auxiliary at least two mixture, the HLB value position 12- of the small molecule auxiliary agent
15, dosage 10-25%.
5. the environmentally friendly double third ring worm ester nanometer pulvis of one kind according to claim 1, it is characterised in that: the high score
Sub- selection of auxiliary water soluble polymer auxiliary agent, including water-soluble macromolecule and its derivative or synthesis macromolecule.
6. the environmentally friendly double third ring worm ester nanometer pulvis of one kind according to claim 5, it is characterised in that: described natural
Water soluble polymer and its derivative include dextrin, cyclodextrin, water soluble starch, oxidized starch, carboxymethyl starch, modified shallow lake
Powder, carboxymethyl cellulose, hydroxyethyl hydroxypropyl base cellulose；Carboxymethyl chitosan, modified guar, Tea Saponin, the synthesis are high
Molecule selects polyvinyl alcohol, Sodium Polyacrylate, polyacrylamide, polypyrrole alkanone, polystyrene-maleic acid sodium, described
Water soluble polymer selection of auxiliary is one such or several.
7. a kind of environmentally friendly double third ring worm ester nanometer pulvis preparation methods, it is characterised in that: the preparation method include with
Lower step,
(1) a certain amount of pesticide original medicine is dissolved in solvent or in the mixed solvent, be configured to close to saturated solution, referred to as component A；
(2) a certain amount of pluronic polymer is dissolved in water, stirs, is configured to certain density aqueous solution, referred to as component B；
(3) a certain amount of small molecule auxiliary agent is added in component B, stirring is configured to composite assistant solution, referred to as component C；
(4) under agitation, it by the pesticide solution, that is, component A, instills in composite assistant solution, that is, component C, controls rate of addition,
So that it is not generated precipitating, and keep solution transparent, becomes component D；
(5) component D is spray-dried, obtains target product.
8. the environmentally friendly double third ring worm ester nanometer pulvis preparation methods of one kind according to claim 7, it is characterised in that:
Pesticide original medicine in the step (1) includes active components A, and the active components A is double third ring worm esters.
9. the environmentally friendly double third ring worm ester nanometer pulvis preparation methods of one kind according to claim 7, it is characterised in that:
Pluronic polymer in the step (2) is selected from dextrin, cyclodextrin, water soluble starch, oxidized starch, carboxymethyl starch, modification
Starch, carboxymethyl cellulose, hydroxyethyl hydroxypropyl base cellulose, carboxymethyl chitosan, modified guar, Tea Saponin, the synthesis
Macromolecule select polyvinyl alcohol, Sodium Polyacrylate, polyacrylamide, polypyrrole alkanone, in polystyrene-maleic acid sodium
It is one or more of.
10. the environmentally friendly double third ring worm ester nanometer pulvis preparation methods of one kind according to claim 7, feature exist
In: the small molecule auxiliary agent in the step (3) is selected from the straight chain alkane that carboxylate, sulfonate, sulfate, different carbon atom numbers are constituted
Base ether, ester, amide polyoxyethylene ether at least two, the HLB value position 12-15 of the small molecule auxiliary agent, dosage 10-
25%.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811632002.7A CN109757509A (en) | 2018-12-29 | 2018-12-29 | Environmentally friendly double third ring worm ester nanometer pulvis of one kind and preparation method thereof |
| PCT/IB2019/057429 WO2020136451A1 (en) | 2018-12-28 | 2019-09-04 | Method for preparing miscible nano-pesticide suspension |
| GB2010113.5A GB2587264B (en) | 2018-12-28 | 2019-09-04 | Method for preparing miscible nanosuspension |
| GB2010112.7A GB2585502B (en) | 2018-12-28 | 2019-09-04 | Miscible nanosuspension |
| PCT/IB2019/057428 WO2020136450A1 (en) | 2018-12-28 | 2019-09-04 | Miscible nano-sized pesticide suspension |
| CN201980086511.0A CN113260257B (en) | 2018-12-28 | 2019-12-26 | Nano pesticide preparation and preparation method thereof |
| PCT/CN2019/128757 WO2020135600A1 (en) | 2018-12-28 | 2019-12-26 | Nano pesticide formulation and preparation method therefor |
| PCT/CN2019/129436 WO2020135780A1 (en) | 2018-12-28 | 2019-12-27 | Nano agro-chemical preparation, and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811632002.7A CN109757509A (en) | 2018-12-29 | 2018-12-29 | Environmentally friendly double third ring worm ester nanometer pulvis of one kind and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN109757509A true CN109757509A (en) | 2019-05-17 |
Family
ID=66452616
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| CN201811632002.7A Withdrawn CN109757509A (en) | 2018-12-28 | 2018-12-29 | Environmentally friendly double third ring worm ester nanometer pulvis of one kind and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020135780A1 (en) * | 2018-12-28 | 2020-07-02 | 南京善思生物科技有限公司 | Nano agro-chemical preparation, and preparation method therefor |
| WO2020136451A1 (en) * | 2018-12-28 | 2020-07-02 | 张子勇 | Method for preparing miscible nano-pesticide suspension |
-
2018
- 2018-12-29 CN CN201811632002.7A patent/CN109757509A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020135780A1 (en) * | 2018-12-28 | 2020-07-02 | 南京善思生物科技有限公司 | Nano agro-chemical preparation, and preparation method therefor |
| WO2020136451A1 (en) * | 2018-12-28 | 2020-07-02 | 张子勇 | Method for preparing miscible nano-pesticide suspension |
| WO2020135600A1 (en) * | 2018-12-28 | 2020-07-02 | 南京善思生物科技有限公司 | Nano pesticide formulation and preparation method therefor |
| GB2587264A (en) * | 2018-12-28 | 2021-03-24 | Zhang Ziyong | Method for preparing miscible nano-pesticide suspension |
| CN113260257A (en) * | 2018-12-28 | 2021-08-13 | 南京善思生物科技有限公司 | Nano pesticide preparation and preparation method thereof |
| CN113260257B (en) * | 2018-12-28 | 2022-09-06 | 南京善思生物科技有限公司 | Nano pesticide preparation and preparation method thereof |
| GB2587264B (en) * | 2018-12-28 | 2022-11-09 | Zhang Ziyong | Method for preparing miscible nanosuspension |
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Application publication date: 20190517 |
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