CN109745508A - A kind of Chinese materia medica preparation and preparation method thereof of anti-curing oncoma - Google Patents
A kind of Chinese materia medica preparation and preparation method thereof of anti-curing oncoma Download PDFInfo
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- CN109745508A CN109745508A CN201910213585.8A CN201910213585A CN109745508A CN 109745508 A CN109745508 A CN 109745508A CN 201910213585 A CN201910213585 A CN 201910213585A CN 109745508 A CN109745508 A CN 109745508A
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Abstract
The invention discloses a kind of Chinese materia medica preparations of anti-curing oncoma, are prepared by the raw material of following parts by weight: 20~30 parts of nostoc micro mist, 10~20 parts of Radix Astragali, 10~20 parts of spina gleditsiae, 10~15 parts of cicada fungus conidia powder, 10~20 parts of honeysuckle, 5~10 parts of Chinese violet, 10~15 parts of fructus lycii, 5~10 parts of radix ranunculi ternati, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of teasel, 10~15 parts of Chinese actinidia root, 10~20 parts of wilsonii, 6~10 parts of curcuma zedoary, 5~10 parts of Radix Codonopsis, 15~20 parts of the root bark of tree peony, 10~20 parts of semen coicis, 5~10 parts of radix glycyrrhizae preparata.The present invention have removing toxic substances relieve pain, strengthen the body resistance to consolidate the constitution, resolving hard lump, killing cancer cell, inhibit growth of cancer cells, raising immunity of organisms, the effect of pre- preventing tumor.The medicine mostly uses greatly natural component, takes safety, and non-evident effect has no that patient has adverse reaction through many years clinical observation, and patient is suitble to take for a long time.
Description
Technical field
The present invention relates to field of traditional Chinese medicine preparations, and in particular to a kind of Chinese materia medica preparation and preparation method thereof of anti-curing oncoma.
Background technique
Recently as the development of economic society, although people's living standard is being continuously improved, the disease incidence of tumour and
The death rate is but constantly rising.Currently, the method for the treatment of tumour mainly includes chemotherapy and radiation, although both treatment methods have
Certain curative effect, but side effect is obvious, it is easy to destroy the immunity of patient itself.
Traditional Chinese medicine not only has inhibiting effect to tumour cell, can enhance immune function with auxiliary body, for mitigating
The symptom and pain of tumor patient, improve life quality, and extending life reduces the death rate of cancer, there is its important meaning.
Summary of the invention
To solve the above problems, the present invention provides a kind of Chinese materia medica preparation and preparation method thereof of anti-curing oncoma, the Chinese medicine
Preparation have removing toxic substances relieve pain, strengthen the body resistance to consolidate the constitution, resolving hard lump, killing cancer cell, inhibit growth of cancer cells, raising immunity of organisms,
The effect of pre- preventing tumor, and non-evident effect.
To achieve the above object, the technical scheme adopted by the invention is as follows:
A kind of Chinese materia medica preparation of anti-curing oncoma, is prepared by the raw material of following parts by weight:
20~30 parts of nostoc micro mist, 10~20 parts of Radix Astragali, 10~20 parts of spina gleditsiae, 10~15 parts of cicada fungus conidia powder, honeysuckle 10
~20 parts, 5~10 parts of Chinese violet, 10~15 parts of fructus lycii, 5~10 parts of radix ranunculi ternati, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of teasel, rattan
10~15 parts of pears root, 10~20 parts of wilsonii, 6~10 parts of curcuma zedoary, 5~10 parts of Radix Codonopsis, 15~20 parts of the root bark of tree peony, semen coicis 10~20
Part, 5~10 parts of radix glycyrrhizae preparata.
Further, it is prepared by the raw material of following parts by weight:
20 parts of nostoc micro mist, 10 parts of Radix Astragali, 10 parts of spina gleditsiae, 10 parts of cicada fungus conidia powder, 10 parts of honeysuckle, 5 parts of Chinese violet, fructus lycii
10 parts, 5 parts of radix ranunculi ternati, 10 parts of Rhizoma Chuanxiong, 10 parts of teasel, 10 parts of Chinese actinidia root, 10 parts of wilsonii, 6 parts of curcuma zedoary, 5 parts of Radix Codonopsis, the root bark of tree peony
15 parts, 10 parts of semen coicis, 5 parts of radix glycyrrhizae preparata.
Further, it is prepared by the raw material of following parts by weight:
30 parts of nostoc micro mist, 20 parts of Radix Astragali, 20 parts of spina gleditsiae, 15 parts of cicada fungus conidia powder, 20 parts of honeysuckle, 10 parts of Chinese violet, fructus lycii
15 parts, 10 parts of radix ranunculi ternati, 15 parts of Rhizoma Chuanxiong, 15 parts of teasel, 15 parts of Chinese actinidia root, 20 parts of wilsonii, 10 parts of curcuma zedoary, 10 parts of Radix Codonopsis,
20 parts of the root bark of tree peony, 20 parts of semen coicis, 10 parts of radix glycyrrhizae preparata.
Further, it is prepared by the raw material of following parts by weight:
25 parts of nostoc micro mist, 15 parts of Radix Astragali, 15 parts of spina gleditsiae, 12.5 parts of cicada fungus conidia powder, 15 parts of honeysuckle, 7.5 parts of Chinese violet,
12.5 parts of fructus lycii, 7.5 parts of radix ranunculi ternati, 12.5 parts of Rhizoma Chuanxiong, 12.5 parts of teasel, 12.5 parts of Chinese actinidia root, 15 parts of wilsonii, curcuma zedoary 8
Part, 7.5 parts of Radix Codonopsis, 17.5 parts of the root bark of tree peony, 15 parts of semen coicis, 7.5 parts of radix glycyrrhizae preparata.
Further, the nostoc micro mist is as obtained by following steps preparation:
Under the conditions of nostoc after clean draining is placed in -10 DEG C, after 3~5h of freezing processing, under the conditions of 20~30 DEG C, into
The processing of row supersonic wave wall breaking obtains nostoc slurry;
Resulting nostoc slurry is placed in enzymatic vessel, the water of celestial 3~8 times of amounts of Rice & peanut milk is added, and be by mass percentage 0.5-
Neutral proteinase is added in 2% ratio, digests 0.5-2h at 30-50 DEG C, filters, obtains enzymolysis liquid;
Enzymolysis liquid is heated to 90~100 DEG C, 5~15min is kept to be cooled to room temperature with inactivator, is refiltered to remove enzymatic hydrolysis
Solid impurity in liquid, spray drying to get.
The present invention also provides a kind of above-mentioned preparation methods of the Chinese materia medica preparation of anti-curing oncoma, include the following steps:
S1, each component is weighed by above-mentioned formula;
S2, by weighed Radix Astragali, spina gleditsiae, honeysuckle, Chinese violet, fructus lycii, radix ranunculi ternati, Rhizoma Chuanxiong, teasel, Chinese actinidia root, wilsonii, cowherb
After art, Radix Codonopsis, the root bark of tree peony, semen coicis, radix glycyrrhizae preparata are cleaned, slice/section is placed in extractor, past according to the ratio of 1g:15~25mL
After 2~3h of alcohol solution dipping that volumetric concentration is 65~75% is added in Chinese medicine, instantaneous high pressure processing is carried out, adjusts pressure
For 150~200 MPa, circular treatment 3~5 times, processing flow velocity is 6~10L/h, the temperature of ethanol solution 10~20 DEG C it
Between, after processing, Chinese medicine is pulled out, ethyl alcohol is spare;
S3, the Chinese medicine pulled out is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7~1.5MPa, explosion
Handle 7~23min;Then being passed through steam to steam explosion pressure inside the tank rapidly is 1.5~2.1MPa, Steam explosion treatment 0.8~2.8
After min, after the resulting ethanol solution of steps for importing S2 handles 20~30min at 30~50 DEG C, concentration and recovery ethyl alcohol, freezing is done
It is dry to get extract;
S4, by weighed nostoc micro mist, cicada fungus conidia powder and resulting extract mix after, by specification packaging to get.
The invention has the following advantages:
It relieving pain, strengthens the body resistance to consolidate the constitution, resolving hard lump with removing toxic substances, killing cancer cell inhibits growth of cancer cells, immunity of organisms is improved,
The effect of pre- preventing tumor.The medicine mostly uses greatly natural component, takes safety, and non-evident effect has no through many years clinical observation
Patient has adverse reaction, and patient is suitble to take for a long time.
Specific embodiment
In order to which objects and advantages of the present invention are more clearly understood, the present invention is carried out with reference to embodiments further
It is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
In following embodiment, the nostoc micro mist is as obtained by following steps preparation:
Under the conditions of nostoc after clean draining is placed in -10 DEG C, after 3~5h of freezing processing, under the conditions of 20~30 DEG C, into
The processing of row supersonic wave wall breaking obtains nostoc slurry;
Resulting nostoc slurry is placed in enzymatic vessel, the water of celestial 3~8 times of amounts of Rice & peanut milk is added, and be by mass percentage 0.5-
Neutral proteinase is added in 2% ratio, digests 0.5-2h at 30-50 DEG C, filters, obtains enzymolysis liquid;
Enzymolysis liquid is heated to 90~100 DEG C, 5~15min is kept to be cooled to room temperature with inactivator, is refiltered to remove enzymatic hydrolysis
Solid impurity in liquid, spray drying to get.
Remaining raw material is commercially available raw material.
Embodiment 1
A kind of Chinese materia medica preparation of anti-curing oncoma, as obtained by following steps preparation:
S1, it weighs by weight: 20 parts of nostoc micro mist, 10 parts of Radix Astragali, 10 parts of spina gleditsiae, 10 parts of cicada fungus conidia powder, honeysuckle 10
Part, 5 parts of Chinese violet, 10 parts of fructus lycii, 5 parts of radix ranunculi ternati, 10 parts of Rhizoma Chuanxiong, 10 parts of teasel, 10 parts of Chinese actinidia root, 10 parts of wilsonii, curcuma zedoary 6
Part, 5 parts of Radix Codonopsis, 15 parts of the root bark of tree peony, 10 parts of semen coicis, 5 parts of radix glycyrrhizae preparata;
S2, by weighed Radix Astragali, spina gleditsiae, honeysuckle, Chinese violet, fructus lycii, radix ranunculi ternati, Rhizoma Chuanxiong, teasel, Chinese actinidia root, wilsonii, cowherb
After art, Radix Codonopsis, the root bark of tree peony, semen coicis, radix glycyrrhizae preparata are cleaned, slice/section is placed in extractor, according to the ratio of 1g:15mL toward Chinese medicine
After the alcohol solution dipping 3h that volumetric concentration is 65% is added in material, instantaneous high pressure processing is carried out, adjusting pressure is 150
MPa, circular treatment 5 times, processing flow velocity is 6L/h, and the temperature of ethanol solution is between 10~20 DEG C, after processing, by Chinese medicine
It pulls out, ethyl alcohol is spare;
S3, the Chinese medicine pulled out is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7MPa, explosion treatment
23min;Then being passed through steam to steam explosion pressure inside the tank rapidly is 1.5MPa, after 2.8 min of Steam explosion treatment, steps for importing S2
After resulting ethanol solution handles 30min at 30 DEG C, concentration and recovery ethyl alcohol is freeze-dried to get extract;
S4, by weighed nostoc micro mist, cicada fungus conidia powder and resulting extract mix after, by specification packaging to get.
Embodiment 2
A kind of Chinese materia medica preparation of anti-curing oncoma, as obtained by following steps preparation:
S1, it weighs by weight: 30 parts of nostoc micro mist, 20 parts of Radix Astragali, 20 parts of spina gleditsiae, 15 parts of cicada fungus conidia powder, honeysuckle 20
Part, 10 parts of Chinese violet, 15 parts of fructus lycii, 10 parts of radix ranunculi ternati, 15 parts of Rhizoma Chuanxiong, 15 parts of teasel, 15 parts of Chinese actinidia root, 20 parts of wilsonii, cowherb
10 parts of art, 10 parts of Radix Codonopsis, 20 parts of the root bark of tree peony, 20 parts of semen coicis, 10 parts of radix glycyrrhizae preparata;
S2, by weighed Radix Astragali, spina gleditsiae, honeysuckle, Chinese violet, fructus lycii, radix ranunculi ternati, Rhizoma Chuanxiong, teasel, Chinese actinidia root, wilsonii, cowherb
After art, Radix Codonopsis, the root bark of tree peony, semen coicis, radix glycyrrhizae preparata are cleaned, slice/section is placed in extractor, according to the ratio of 1g:25mL into
After the alcohol solution dipping 2h that volumetric concentration is 75% is added in medicinal material, instantaneous high pressure processing is carried out, adjusting pressure is 200
MPa, circular treatment 3 times, processing flow velocity is 10L/h, and the temperature of ethanol solution is between 10~20 DEG C, after processing, by Chinese medicine
It pulls out, ethyl alcohol is spare;
S3, the Chinese medicine pulled out is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 1.5MPa, explosion treatment
7min;Then being passed through steam to steam explosion pressure inside the tank rapidly is 2.1MPa, after 0.8 min of Steam explosion treatment, steps for importing S2
After resulting ethanol solution handles 25min at 50 DEG C, concentration and recovery ethyl alcohol is freeze-dried to get extract;
S4, by weighed nostoc micro mist, cicada fungus conidia powder and resulting extract mix after, by specification packaging to get.
Embodiment 3
A kind of Chinese materia medica preparation of anti-curing oncoma, as obtained by following steps preparation:
S1, it weighs by weight: 25 parts of nostoc micro mist, 15 parts of Radix Astragali, 15 parts of spina gleditsiae, 12.5 parts of cicada fungus conidia powder, honeysuckle
15 parts, 7.5 parts of Chinese violet, 12.5 parts of fructus lycii, 7.5 parts of radix ranunculi ternati, 12.5 parts of Rhizoma Chuanxiong, 12.5 parts of teasel, 12.5 parts of Chinese actinidia root, thorn
15 parts of slender acanthopanax, 8 parts of curcuma zedoary, 7.5 parts of Radix Codonopsis, 17.5 parts of the root bark of tree peony, 15 parts of semen coicis, 7.5 parts of radix glycyrrhizae preparata;
S2, by weighed Radix Astragali, spina gleditsiae, honeysuckle, Chinese violet, fructus lycii, radix ranunculi ternati, Rhizoma Chuanxiong, teasel, Chinese actinidia root, wilsonii, cowherb
After art, Radix Codonopsis, the root bark of tree peony, semen coicis, radix glycyrrhizae preparata are cleaned, slice/section is placed in extractor, according to the ratio of 1g:20mL toward Chinese medicine
After the alcohol solution dipping 2.5h that volumetric concentration is 70% is added in material, instantaneous high pressure processing is carried out, adjusting pressure is 175
MPa, circular treatment 4 times, processing flow velocity is 8L/h, and after processing, Chinese medicine is pulled out between 15 DEG C for the temperature of ethanol solution,
Ethyl alcohol is spare;
S3, the Chinese medicine pulled out is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 1.1MPa, explosion treatment
15min;Then being passed through steam to steam explosion pressure inside the tank rapidly is 1.8MPa, after 1.8 min of Steam explosion treatment, steps for importing S2
After resulting ethanol solution handles 25min at 40 DEG C, concentration and recovery ethyl alcohol is freeze-dried to get extract;
S4, after weighed nostoc micro mist, cicada fungus conidia powder and resulting extract are mixed, by specification packaging to get into one
Step ground, is prepared by the raw material of following parts by weight:
One, toxicity test
Selecting weight is the small white mouse 200 (each 100 of male and female) of 18~22g, is divided into 5 groups, every group of male and female each 20, small white mouse
Back unhairing exposes exocuticle, unhairing range 2cm × 2cm, first group to third component not Tu Mo the embodiment of the present invention 1 to reality
Apply the Chinese medicine composition that example 3 is prepared, the 4th group to fifth component not Tu Mo comparative example 1 and comparative example 2 of the present invention be prepared into
The Chinese medicine composition arrived, dosage 5g, successive administration 30 days.When during administration and 1 week after being discontinued, observation white mouse grows shape
State and activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result, it has been found that all little Bai
Mouse health existence, it is without any side effects;Blood picture, liver function, each organs and tissues state is dissected and observed, with normal small white mouse ratio
Compared with indifference.It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic, drug safety is reliable.
Two, composition pharmacodynamic test
General information: accepting tumor patient 300 for medical treatment altogether, is randomly divided into 3 groups, respectively example 1 group, 2 groups of embodiment, embodiment
3 groups.The general information such as gender, age, the drug resistance situation of each group patient compare no significant difference (P > 0.05), and having can
Compare property.
Treatment method: example 1 group, 2 groups of embodiment and 3 groups of embodiment take embodiment 1, embodiment 2, embodiment respectively
Composition obtained by 3, three times a day, each 10g, a month as a treatment course.
Curative effect judging standard:
Effective: lump disappears, and cancer cell is reduced, and immunity increases, energetic, painless;
Effective: effective lump becomes smaller, and cancer cell is substantially achieved inhibition, spiritual not good enough, pain relief;
Invalid: cancer cell is constant, and mental status is poor, still there is pain, and symptom is obvious.
Treatment results: the treatment through 3 courses for the treatment of, as a result statistics see the table below:
Group | Number of cases | It is effective | Effectively | In vain |
Example 1 group | 100 | 50 | 48 | 2 |
2 groups of embodiment | 100 | 56 | 41 | 3 |
3 groups of embodiment | 100 | 59 | 40 | 1 |
The above is only a preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, without departing from the principle of the present invention, can also make several improvements and retouch, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (6)
1. a kind of Chinese materia medica preparation of anti-curing oncoma, which is characterized in that be prepared by the raw material of following parts by weight:
20~30 parts of nostoc micro mist, 10~20 parts of Radix Astragali, 10~20 parts of spina gleditsiae, 10~15 parts of cicada fungus conidia powder, honeysuckle 10
~20 parts, 5~10 parts of Chinese violet, 10~15 parts of fructus lycii, 5~10 parts of radix ranunculi ternati, 10~15 parts of Rhizoma Chuanxiong, 10~15 parts of teasel, rattan
10~15 parts of pears root, 10~20 parts of wilsonii, 6~10 parts of curcuma zedoary, 5~10 parts of Radix Codonopsis, 15~20 parts of the root bark of tree peony, semen coicis 10~20
Part, 5~10 parts of radix glycyrrhizae preparata.
2. a kind of Chinese materia medica preparation of anti-curing oncoma as described in claim 1, which is characterized in that by the raw material system of following parts by weight
It is standby to form:
20 parts of nostoc micro mist, 10 parts of Radix Astragali, 10 parts of spina gleditsiae, 10 parts of cicada fungus conidia powder, 10 parts of honeysuckle, 5 parts of Chinese violet, fructus lycii
10 parts, 5 parts of radix ranunculi ternati, 10 parts of Rhizoma Chuanxiong, 10 parts of teasel, 10 parts of Chinese actinidia root, 10 parts of wilsonii, 6 parts of curcuma zedoary, 5 parts of Radix Codonopsis, the root bark of tree peony
15 parts, 10 parts of semen coicis, 5 parts of radix glycyrrhizae preparata.
3. a kind of Chinese materia medica preparation of anti-curing oncoma as described in claim 1, which is characterized in that by the raw material system of following parts by weight
It is standby to form:
30 parts of nostoc micro mist, 20 parts of Radix Astragali, 20 parts of spina gleditsiae, 15 parts of cicada fungus conidia powder, 20 parts of honeysuckle, 10 parts of Chinese violet, fructus lycii
15 parts, 10 parts of radix ranunculi ternati, 15 parts of Rhizoma Chuanxiong, 15 parts of teasel, 15 parts of Chinese actinidia root, 20 parts of wilsonii, 10 parts of curcuma zedoary, 10 parts of Radix Codonopsis,
20 parts of the root bark of tree peony, 20 parts of semen coicis, 10 parts of radix glycyrrhizae preparata.
4. a kind of Chinese materia medica preparation of anti-curing oncoma as described in claim 1, which is characterized in that by the raw material system of following parts by weight
It is standby to form:
25 parts of nostoc micro mist, 15 parts of Radix Astragali, 15 parts of spina gleditsiae, 12.5 parts of cicada fungus conidia powder, 15 parts of honeysuckle, 7.5 parts of Chinese violet,
12.5 parts of fructus lycii, 7.5 parts of radix ranunculi ternati, 12.5 parts of Rhizoma Chuanxiong, 12.5 parts of teasel, 12.5 parts of Chinese actinidia root, 15 parts of wilsonii, curcuma zedoary 8
Part, 7.5 parts of Radix Codonopsis, 17.5 parts of the root bark of tree peony, 15 parts of semen coicis, 7.5 parts of radix glycyrrhizae preparata.
5. a kind of Chinese materia medica preparation of anti-curing oncoma as described in claim 1, which is characterized in that the nostoc micro mist by with
Lower step preparation gained:
Under the conditions of nostoc after clean draining is placed in -10 DEG C, after 3~5h of freezing processing, under the conditions of 20~30 DEG C, into
The processing of row supersonic wave wall breaking obtains nostoc slurry;
Resulting nostoc slurry is placed in enzymatic vessel, the water of celestial 3~8 times of amounts of Rice & peanut milk is added, and be by mass percentage 0.5-
Neutral proteinase is added in 2% ratio, digests 0.5-2h at 30-50 DEG C, filters, obtains enzymolysis liquid;
Enzymolysis liquid is heated to 90~100 DEG C, 5~15min is kept to be cooled to room temperature with inactivator, is refiltered to remove enzymatic hydrolysis
Solid impurity in liquid, spray drying to get.
6. a kind of preparation method of the Chinese materia medica preparation of anti-curing oncoma as described in claim 1, which is characterized in that including walking as follows
It is rapid:
S1, each component is weighed by the parts by weight;
S2, by weighed Radix Astragali, spina gleditsiae, honeysuckle, Chinese violet, fructus lycii, radix ranunculi ternati, Rhizoma Chuanxiong, teasel, Chinese actinidia root, wilsonii, cowherb
After art, Radix Codonopsis, the root bark of tree peony, semen coicis, radix glycyrrhizae preparata are cleaned, slice/section is placed in extractor, past according to the ratio of 1g:15~25mL
After 2~3h of alcohol solution dipping that volumetric concentration is 65~75% is added in Chinese medicine, instantaneous high pressure processing is carried out, adjusts pressure
For 150~200 MPa, circular treatment 3~5 times, processing flow velocity is 6~10L/h, the temperature of ethanol solution 10~20 DEG C it
Between, after processing, Chinese medicine is pulled out, ethyl alcohol is spare;
S3, the Chinese medicine pulled out is placed in steam-explosion jar, being first passed through nitrogen to steam explosion pressure inside the tank is 0.7~1.5MPa, explosion
Handle 7~23min;Then being passed through steam to steam explosion pressure inside the tank rapidly is 1.5~2.1MPa, Steam explosion treatment 0.8~2.8
After min, after the resulting ethanol solution of steps for importing S2 handles 20~30min at 30~50 DEG C, concentration and recovery ethyl alcohol, freezing is done
It is dry to get extract;
S4, by weighed nostoc micro mist, cicada fungus conidia powder and resulting extract mix after, by specification packaging to get.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113599451A (en) * | 2021-09-18 | 2021-11-05 | 威海德尚医中医药科技有限公司 | A Chinese medicinal composition containing ginsenoside and Phellinus Linteus for treating cancer, and its preparation method |
CN115444908A (en) * | 2022-09-08 | 2022-12-09 | 郑州大学 | Medicine for treating tumor and preparation method thereof |
-
2019
- 2019-03-20 CN CN201910213585.8A patent/CN109745508A/en active Pending
Non-Patent Citations (1)
Title |
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李锦毅等: ""扶正健泰汤对肝癌脾气虚证药效学及细胞周期作用的实验与临床研究"", 《中国实验方剂学杂志》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113599451A (en) * | 2021-09-18 | 2021-11-05 | 威海德尚医中医药科技有限公司 | A Chinese medicinal composition containing ginsenoside and Phellinus Linteus for treating cancer, and its preparation method |
CN115444908A (en) * | 2022-09-08 | 2022-12-09 | 郑州大学 | Medicine for treating tumor and preparation method thereof |
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Application publication date: 20190514 |
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RJ01 | Rejection of invention patent application after publication |