CN109731227B - Transcranial magnetic stimulation system - Google Patents
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- CN109731227B CN109731227B CN201910060788.8A CN201910060788A CN109731227B CN 109731227 B CN109731227 B CN 109731227B CN 201910060788 A CN201910060788 A CN 201910060788A CN 109731227 B CN109731227 B CN 109731227B
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- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 40
- 230000000638 stimulation Effects 0.000 claims abstract description 23
- 238000002595 magnetic resonance imaging Methods 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 11
- 230000001360 synchronised effect Effects 0.000 claims abstract description 4
- 238000003384 imaging method Methods 0.000 claims description 27
- 238000011156 evaluation Methods 0.000 claims description 19
- 238000006073 displacement reaction Methods 0.000 claims description 12
- 238000011282 treatment Methods 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 2
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
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- 208000020016 psychiatric disease Diseases 0.000 description 1
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Abstract
The invention discloses a transcranial magnetic stimulation system which comprises a stimulation unit, a magnetic resonance unit and a synchronization unit, wherein the synchronization unit is used for controlling the stimulation unit and the magnetic resonance unit to be synchronized. The invention can accurately evaluate the curative effect of TMS in real time, and can acquire the magnetic resonance imaging signal of the target preset region in real time while performing transcranial magnetic stimulation on the target; performing real-time magnetic resonance imaging according to the magnetic resonance imaging signal; and continuously adjusting the current waveform parameters of the stimulated region of the target or the coil of the stimulation unit according to the real-time magnetic resonance imaging result until an expected magnetic resonance imaging result of the preset region is obtained.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a transcranial magnetic stimulation system.
Background
Transcranial Magnetic Stimulation (TMS) technology is a Magnetic Stimulation technology that uses a pulsed Magnetic field to act on the central nervous system (mainly the brain) to change the membrane potential of cortical nerve cells, so that induced current is generated to influence intracerebral metabolism and neuroelectrical activity, thereby causing a series of physiological and biochemical reactions. TMS regulates neuronal electrical activity to a certain extent and has found widespread use in the treatment of parkinson's disease, depression and other psychiatric and neurological disorders.
However, since the specific mechanism of the TMS clinical therapy is not known at present, the treatment is somewhat blinded, so that the stimulation site is not accurate enough and the side effects are not easily evaluated. After the patient is treated by TMS, a special magnetic resonance examination is needed to acquire the magnetic resonance data of the treatment part so as to evaluate the treatment effect of TMS. Obviously, this method of evaluating efficacy takes a lot of time and economic cost, and the evaluation result is not accurate.
Disclosure of Invention
The invention aims to provide a transcranial magnetic stimulation system which can accurately evaluate the curative effect of TMS in real time so as to enable the TMS to be positioned more accurately.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention discloses a transcranial magnetic stimulation system which comprises a stimulation unit, a magnetic resonance unit and a synchronization unit, wherein the synchronization unit is used for controlling the stimulation unit and the magnetic resonance unit to be synchronized.
Furthermore, the invention comprises an evaluation subsystem, wherein the evaluation unit evaluates the stimulation effect of the stimulation unit according to the imaging result of the magnetic resonance unit.
Preferably, the evaluation subsystem comprises a first comparison unit for comparing a first image similarity of an imaging result of the magnetic resonance unit after transcranial magnetic stimulation and an imaging result of the magnetic resonance unit without transcranial magnetic stimulation.
Further, the evaluation subsystem comprises a second comparison unit for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with a second image similarity of the imaging result of the magnetic resonance unit after the last transcranial magnetic stimulation.
Further, the evaluation subsystem comprises a third comparison unit, and the third comparison unit is used for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with a third image similarity of the pre-stored imaging result of the magnetic resonance unit; the pre-stored imaging result of the magnetic resonance unit may be an imaging result of the magnetic resonance unit which is effective in the previous treatment, or an imaging result of the magnetic resonance unit which is expected to be achieved.
Furthermore, the invention also comprises a positioning unit, wherein the positioning unit is used for positioning the coil position of the stimulation unit.
Further, the invention also comprises a displacement control unit, wherein the displacement control unit is used for controlling the displacement of the coil.
Preferably, the displacement control unit is controlled by the evaluation subsystem, and the control amount of the displacement control unit is associated with the first image similarity and/or the second image similarity and/or the third image similarity.
Furthermore, the invention also comprises a coil current waveform control unit, wherein the coil current waveform control unit is used for controlling current waveform parameters of the coil of the stimulation unit, and the current waveform parameters comprise pulse amplitude, pulse frequency, duty ratio of pulses and pulse number.
Preferably, the control amount of the coil current waveform control unit is associated with the first image similarity and/or the second image similarity and/or the third image similarity.
The invention can acquire the magnetic resonance imaging signal of the target preset region in real time while performing transcranial magnetic stimulation on the target; performing real-time magnetic resonance imaging according to the magnetic resonance imaging signal; and continuously adjusting the stimulated region of the target according to the real-time magnetic resonance imaging result until an expected magnetic resonance imaging result of the preset region is obtained.
The invention can carry out real-time magnetic resonance on the preset area, check the magnetic resonance imaging result in real time and adjust the stimulated area of the target in real time while carrying out transcranial magnetic stimulation, so compared with the prior art, the invention has more accurate positioning on the stimulated area, can carry out real-time and accurate evaluation on the curative effect of TMS and saves manpower and material resources to a certain extent.
The real-time functional magnetic resonance RealTime fMRI provided by the invention can be used for real-time evaluation, the treatment accuracy is improved, and the response of the brain in TMS nerve regulation can be observed in time.
Drawings
FIG. 1 is a functional block diagram of the present invention;
fig. 2 is a flow chart of the application of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings.
As shown in figure 1, the transcranial magnetic stimulation system disclosed by the invention comprises a stimulation unit, a magnetic resonance unit and a synchronization unit, wherein the synchronization unit is used for controlling the stimulation unit and the magnetic resonance unit to be synchronized.
The invention also comprises an evaluation subsystem, an evaluation unit for evaluating the stimulation effect of the stimulation unit according to the imaging result of the magnetic resonance unit; specifically, the evaluation subsystem comprises a first comparison unit, a second comparison unit and a third comparison unit, wherein the first comparison unit is used for comparing the imaging result of the magnetic resonance unit after transcranial magnetic stimulation with the first image similarity of the imaging result of the magnetic resonance unit without transcranial magnetic stimulation; the second comparison unit is used for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with the second image similarity of the imaging result of the magnetic resonance unit after the last transcranial magnetic stimulation; the third comparison unit is used for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with a third image similarity of the pre-stored imaging result of the magnetic resonance unit, and the pre-stored imaging result of the magnetic resonance unit can be an imaging result of the magnetic resonance unit with a good effect in the early treatment and can also be an imaging result of the magnetic resonance unit which is expected to be achieved.
The invention also comprises a positioning unit, a displacement control unit and a coil current waveform control unit, wherein the positioning unit is used for positioning the coil position of the stimulation unit; the displacement control unit is used for controlling the displacement of the coil and can be controlled by the evaluation subsystem, and the control quantity of the displacement control unit is related to the first image similarity and/or the second image similarity and/or the third image similarity; the coil current waveform control unit is used for controlling current waveform parameters of a coil of the stimulation unit, the current waveform parameters comprise pulse amplitude, pulse frequency, duty ratio of pulses and pulse number, and control quantity of the coil current waveform control unit is related to the first image similarity and/or the second image similarity and/or the third image similarity.
As shown in FIG. 2, in practice, the present invention can be used according to the following steps: :
and step 102, continuously adjusting the stimulated region of the target according to the real-time magnetic resonance imaging result until an expected magnetic resonance imaging result of the preset region is obtained.
And the adjusting and positioning device is used for continuously adjusting the stimulated region of the target according to the real-time magnetic resonance imaging result until the real-time functional magnetic resonance imaging device obtains an expected magnetic resonance imaging result of the preset region.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention.
Claims (4)
1. A system for transcranial magnetic stimulation, characterized by: the magnetic resonance imaging device comprises a stimulation unit, a magnetic resonance unit and a synchronization unit, wherein the synchronization unit is used for controlling the stimulation unit and the magnetic resonance unit to be synchronized;
the evaluation subsystem evaluates the stimulation effect of the stimulation unit according to the imaging result of the magnetic resonance unit;
the evaluation subsystem comprises a first comparison unit for comparing a first image similarity of an imaging result of the magnetic resonance unit after transcranial magnetic stimulation and an imaging result of the magnetic resonance unit without transcranial magnetic stimulation;
the evaluation subsystem comprises a second comparison unit, and the second comparison unit is used for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with the second image similarity of the imaging result of the magnetic resonance unit after the last transcranial magnetic stimulation;
the evaluation subsystem comprises a third comparison unit, and the third comparison unit is used for comparing the imaging result of the magnetic resonance unit after the current transcranial magnetic stimulation with a third image similarity of the pre-stored imaging result of the magnetic resonance unit;
the displacement control unit is used for controlling the displacement of the coil and is controlled by the evaluation subsystem, and the control quantity of the displacement control unit is related to the first image similarity and/or the second image similarity and/or the third image similarity.
2. The system of transcranial magnetic stimulation according to claim 1, wherein: the device also comprises a positioning unit, wherein the positioning unit is used for positioning the coil position of the stimulation unit.
3. The system of transcranial magnetic stimulation according to claim 1, wherein: the device also comprises a coil current waveform control unit, wherein the coil current waveform control unit is used for controlling current waveform parameters of the coil of the stimulation unit, and the current waveform parameters comprise pulse amplitude, pulse frequency, duty ratio of pulses and pulse number.
4. The system of transcranial magnetic stimulation according to claim 3, wherein: the coil current waveform control unit is controlled by the evaluation subsystem, and the control quantity of the coil current waveform control unit is related to the first image similarity and/or the second image similarity and/or the third image similarity.
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| CN201811237670X | 2018-10-23 | ||
| CN201811237670 | 2018-10-23 |
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| CN109731227A CN109731227A (en) | 2019-05-10 |
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| CN110262336B (en) * | 2019-06-18 | 2021-02-02 | 中国科学院自动化研究所 | Current output circuit and transcranial electrical stimulation device comprising same |
| CN110477917A (en) * | 2019-08-13 | 2019-11-22 | 深圳先进技术研究院 | Intracerebral lymphatic vessel stimulating system, method and control device |
| CN111568372A (en) * | 2020-04-08 | 2020-08-25 | 深圳市神经科学研究院 | Ultrasonic stimulation magnetic resonance imaging synchronization method and device |
| CN111657947B (en) * | 2020-05-21 | 2022-07-05 | 四川大学华西医院 | Positioning method of nerve regulation target area |
| CN114190922B (en) * | 2020-09-18 | 2023-04-21 | 四川大学 | TMS head movement detection method |
| WO2023108348A1 (en) * | 2021-12-13 | 2023-06-22 | 深圳先进技术研究院 | Meningeal lymphatic vessel stimulation device |
| CN115910356B (en) * | 2022-11-11 | 2023-07-25 | 深圳职业技术学院 | Magnetic field stimulation effect evaluation method based on transcranial magnetic stimulation coil electromagnetic field simulation |
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| US20060173274A1 (en) * | 2002-07-15 | 2006-08-03 | George Mark S | Functional magnetic resonance imaging guided transcranial magnetic stimulation deception inhibitor |
| CN101912668B (en) * | 2010-07-26 | 2013-04-10 | 香港脑泰科技有限公司 | Navigation transcranial magnetic stimulation treatment system |
| US9924889B2 (en) * | 2013-10-03 | 2018-03-27 | Medical University Of Vienna | Method and system for combined transcranial magnetic simulation (TMS) and functional magnetic resonance imaging (fMRI) studies |
| CN106345062B (en) * | 2016-09-20 | 2018-01-16 | 华东师范大学 | A kind of cerebral magnetic stimulation coil localization method based on magnetic resonance imaging |
| CN107497049A (en) * | 2017-09-30 | 2017-12-22 | 武汉资联虹康科技股份有限公司 | A kind of electromagnetic location air navigation aid and device for transcranial magnetic stimulation device |
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