CN111568372A - Ultrasonic stimulation magnetic resonance imaging synchronization method and device - Google Patents
Ultrasonic stimulation magnetic resonance imaging synchronization method and device Download PDFInfo
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- CN111568372A CN111568372A CN202010282800.2A CN202010282800A CN111568372A CN 111568372 A CN111568372 A CN 111568372A CN 202010282800 A CN202010282800 A CN 202010282800A CN 111568372 A CN111568372 A CN 111568372A
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- 230000000638 stimulation Effects 0.000 title claims abstract description 75
- 238000002595 magnetic resonance imaging Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 25
- 239000000523 sample Substances 0.000 claims abstract description 21
- 238000002604 ultrasonography Methods 0.000 claims description 20
- 230000008054 signal transmission Effects 0.000 claims description 2
- 238000002599 functional magnetic resonance imaging Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 2
- 230000007383 nerve stimulation Effects 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 238000011298 ablation treatment Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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Abstract
The invention discloses an ultrasonic stimulation magnetic resonance imaging synchronization method and device, wherein the method comprises the following steps: and receiving a trigger signal sent by the magnetic resonance system, sending a control signal to the ultrasonic pulse control unit, and controlling the ultrasonic probe to send a preset stimulation signal. The invention receives the trigger signal sent by the magnetic resonance system, sends a control signal to the ultrasonic pulse control unit, and controls the ultrasonic probe to send a preset stimulation signal, so that the magnetic resonance system can accurately capture functional magnetic resonance imaging data under ultrasonic stimulation, and the magnetic resonance system has important use value in clinic and scientific research.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to an ultrasonic stimulation magnetic resonance imaging synchronization method and device.
Background
Ultrasound, a mechanical wave, is generated by the vibration of an object (acoustic source) and caused to propagate through a medium that compresses and expands. Medical ultrasound generally refers to sound waves with frequencies in the interval 20kHz to 10 MHz.
The traditional ultrasound is developed to have two basic functions of imaging diagnosis and thermal ablation treatment based on fluctuation effect and thermal effect, and the existing research based on ultrasound nerve stimulation cannot accurately observe the nerve reaction caused by the action of ultrasound on a nervous system through an imaging system, so that the development of ultrasound nerve stimulation is hindered.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides an ultrasonic stimulation magnetic resonance imaging synchronization system which can solve the synchronization problem of ultrasonic stimulation and magnetic resonance imaging, so that a user can acquire functional magnetic resonance imaging data under real-time ultrasonic stimulation.
The invention also provides an ultrasonic stimulation magnetic resonance imaging synchronization device.
The invention also provides a computer readable storage medium.
In a first aspect, an embodiment of the present invention provides a synchronization method for ultrasound-excited magnetic resonance imaging: the method comprises the following steps:
a trigger signal from the magnetic resonance system is received,
and sending a control signal to the ultrasonic pulse control unit to control the ultrasonic probe to send a preset stimulation signal.
Further, the stimulation signal parameters include: delay, frequency, stimulation string duration, stimulation string interval, and stimulation string number.
Further, the method also comprises the step of receiving a trigger signal sent by a microphone or a keyboard or a screen.
Further, the ultrasound probe includes one or more.
Further, the method also comprises the following steps: recording the stimulation signal and the trigger signal in a log.
Further, the method also comprises the following steps: the stimulation signal is graphically displayed in a screen.
Further, the controlling the ultrasonic probe to emit the preset stimulation signal includes:
generating pulse signals with preset frequency and amplitude through a signal generating module,
and controlling the pulse signal interval output by a counter to generate the stimulation signal.
In a second aspect, an embodiment of the present invention provides an ultrasound-excited magnetic resonance imaging synchronization apparatus, including,
the trigger signal receiving module is used for receiving a trigger signal sent by the magnetic resonance system;
and the stimulation signal sending module is used for sending a control signal to the ultrasonic pulse control unit and controlling the ultrasonic probe to send a preset stimulation signal.
Further, the stimulation signal transmission module includes,
a signal generating unit for generating a pulse signal of a preset frequency and amplitude,
and the counter unit is used for controlling the pulse signal interval output so as to generate the stimulation signal.
Further, the computer-readable storage medium stores computer-executable instructions for causing a computer to perform the ultrasound-stimulated magnetic resonance imaging synchronization method.
The ultrasonic stimulation magnetic resonance imaging synchronization method provided by the embodiment of the invention at least has the following beneficial effects: the triggering signal sent by the magnetic resonance system is received, the control signal is sent to the ultrasonic pulse control unit, and the ultrasonic probe is controlled to send the preset stimulation signal, so that the magnetic resonance system can accurately capture functional magnetic resonance imaging data under ultrasonic stimulation, and the magnetic resonance system has important use values in clinic and scientific research.
Drawings
FIG. 1 is a block diagram of a configuration of an embodiment of a synchronization apparatus for ultrasound-stimulated magnetic resonance imaging according to an embodiment of the present invention;
FIG. 2 is a diagram of an embodiment of a parameter control module of a synchronization apparatus for ultrasound-stimulated magnetic resonance imaging according to the present invention;
FIG. 3 is a flowchart illustrating an embodiment of a method for synchronizing MRI in accordance with the present invention;
FIG. 4 is a schematic flow chart illustrating an embodiment of generation of a stimulation signal in a synchronous method for ultrasound-stimulated magnetic resonance imaging according to an embodiment of the present invention;
FIG. 5 is a schematic representation of a stimulation signal in an embodiment of a method for synchronizing ultrasound-excited magnetic resonance imaging in an embodiment of the present invention.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
In the description of the present invention, if an orientation description is referred to, for example, the orientations or positional relationships indicated by "upper", "lower", "front", "rear", "left", "right", etc. are based on the orientations or positional relationships shown in the drawings, only for convenience of describing the present invention and simplifying the description, but not for indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. If a feature is referred to as being "disposed," "secured," "connected," or "mounted" to another feature, it can be directly disposed, secured, or connected to the other feature or indirectly disposed, secured, connected, or mounted to the other feature.
In the description of the embodiments of the present invention, if "a number" is referred to, it means one or more, if "a plurality" is referred to, it means two or more, if "greater than", "less than" or "more than" is referred to, it is understood that the number is not included, and if "greater than", "lower" or "inner" is referred to, it is understood that the number is included. If reference is made to "first" or "second", this should be understood to distinguish between features and not to indicate or imply relative importance or to implicitly indicate the number of indicated features or to implicitly indicate the precedence of the indicated features.
Referring to fig. 1, fig. 1 is a block diagram illustrating a configuration of an ultrasound-stimulated magnetic resonance imaging synchronization apparatus according to an embodiment of the present invention, including,
the trigger signal receiving module is used for receiving a trigger signal sent by the magnetic resonance system;
and the stimulation signal sending module is used for sending a control signal to the ultrasonic pulse control unit and controlling the ultrasonic probe to send a preset stimulation signal.
The trigger signal receiving module is connected with the magnetic resonance system through an optical fiber or a cable, receives a trigger signal sent by the magnetic resonance system, is connected with a computer through a USB interface, the computer is provided with a parameter control module, the function of the parameter control module can refer to FIG. 2, and the duration, the interval, the frequency, the number and the delay of stimulation strings of the stimulation signals can be adjusted through the parameter control module.
In this embodiment, the number of the ultrasound probes may be one or more, each ultrasound probe corresponds to one output channel of the stimulation signal sending module, and channels may be added or deleted through the parameter control module to control the ultrasound probes with different numbers.
Specifically, the stimulation signal sending module comprises a stimulation signal sending module,
a signal generating unit for generating a pulse signal of a preset frequency and amplitude,
and the counter unit is used for controlling the pulse signal interval output so as to generate the stimulation signal.
The embodiment of the invention also discloses an ultrasonic stimulation magnetic resonance imaging synchronization method, which specifically comprises the following steps of:
s0, receiving a trigger signal sent by the magnetic resonance system,
and S1, sending a control signal to the ultrasonic pulse control unit, and controlling the ultrasonic probe to send a preset stimulation signal.
After receiving the trigger signal sent by the magnetic resonance system, the present embodiment sends a control signal to the ultrasonic pulse control unit, and controls the ultrasonic probe to send a signal of preset stimulation. At the moment, the functional magnetic resonance image acquired by the magnetic resonance system after the subject receives the ultrasonic pulse stimulation effectively solves the problems that the ultrasonic stimulation and the magnetic resonance imaging cannot be synchronized and the effect and influence of the ultrasonic pulse stimulation cannot be verified, and has important values in clinic and scientific research.
Specifically, the stimulation signal parameters include: the time delay is the time interval from receiving the trigger signal to sending out the stimulation signal, the frequency, the stimulation string duration, the stimulation string interval and the number of the stimulation strings.
In another embodiment, the method further comprises receiving a trigger signal sent by a microphone or a keyboard or a screen, namely the trigger signal can be sent by the magnetic resonance system and can be sent by the microphone, the keyboard or the screen.
The number of the ultrasonic probes can be one or more, the control signals can be simultaneously sent to a plurality of groups of ultrasonic probes, a user can increase or delete the number of channels to send out a plurality of groups of stimulation signals, the stimulation signals can be independently configured, different ultrasonic probes are accurately controlled to output different stimulation signals, in the embodiment, the stimulation signals are displayed on a screen in a graphical mode, and as shown in fig. 2, the editing and the checking are convenient.
Specifically, as shown in fig. 4, controlling the ultrasound probe to emit the preset stimulation signal includes:
s10, generating a pulse signal with preset frequency and amplitude through a signal generating module,
s11, the counter controls the pulse signal interval output to generate the stimulation signal, the stimulation signal is generally a stimulation string, and therefore the counter controls the interval time T of the pulse signal input to the ultrasonic pulse control unit to generate the stimulation signal in the form of stimulation string as shown in fig. 5.
In the embodiment, logs are automatically generated, relevant information such as the generation time, the frequency and the amplitude of the trigger signals and the stimulation signals is recorded, the working state of the system and the user parameter setting/modifying history are recorded by detailed timestamps, and a user can call the history parameter setting at any time to support the export and printing of the logs.
The embodiment of the invention also discloses a computer-readable storage medium, which stores computer-executable instructions, wherein the computer-executable instructions are used for causing a computer to execute the ultrasonic stimulation magnetic resonance imaging synchronization method.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
Claims (10)
1. An ultrasound-excited magnetic resonance imaging synchronization method is characterized by comprising the following steps:
a trigger signal from the magnetic resonance system is received,
and sending a control signal to the ultrasonic pulse control unit to control the ultrasonic probe to send a preset stimulation signal.
2. An ultrasound-excited magnetic resonance imaging synchronization method according to claim 1, wherein the parameters of the stimulation signal include: delay, frequency, stimulation string duration, stimulation string interval, and stimulation string number.
3. An ultrasound-excited magnetic resonance imaging synchronization method as claimed in claim 1, further comprising receiving a trigger signal sent by a microphone or a keyboard or a screen.
4. An ultrasound-excited magnetic resonance imaging synchronization method as claimed in claim 1, wherein the ultrasound probe comprises one or more.
5. The ultrasound-excited magnetic resonance imaging synchronization method according to claim 1, further comprising the steps of: recording the stimulation signal and the trigger signal in a log.
6. The ultrasound-excited magnetic resonance imaging synchronization method according to claim 1, further comprising the steps of: the stimulation signal is graphically displayed in a screen.
7. The method of claim 1, wherein the controlling the ultrasound probe to emit the preset stimulation signal comprises:
generating pulse signals with preset frequency and amplitude through a signal generating module,
and controlling the pulse signal interval output by a counter to generate the stimulation signal.
8. An ultrasonic stimulation magnetic resonance imaging synchronizer is characterized by comprising,
the trigger signal receiving module is used for receiving a trigger signal sent by the magnetic resonance system;
and the stimulation signal sending module is used for sending a control signal to the ultrasonic pulse control unit and controlling the ultrasonic probe to send a preset stimulation signal.
9. The ultrasound stimulation magnetic resonance imaging synchronization apparatus according to claim 8, wherein the stimulation signal transmission module comprises,
a signal generating unit for generating a pulse signal of a preset frequency and amplitude,
and the counter unit is used for controlling the pulse signal interval output so as to generate the stimulation signal.
10. The ultrasound-stimulated magnetic resonance imaging synchronizer of claim 9, further comprising a parameter control module for setting parameters of the pulse signal.
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| CN202010282800.2A CN111568372A (en) | 2020-04-08 | 2020-04-08 | Ultrasonic stimulation magnetic resonance imaging synchronization method and device |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093937A (en) * | 1993-03-11 | 1994-10-26 | 乌尔姆技术大学生物医学中央研究所 | The method and apparatus of neuromagnetic stimulation |
| CN103349551A (en) * | 2013-07-08 | 2013-10-16 | 深圳先进技术研究院 | Magnetic resonance elasticity imaging method and system |
| CN105078455A (en) * | 2014-05-15 | 2015-11-25 | 中国科学院上海生命科学研究院 | Functional magnetic resonance imaging synchronous monitoring and triggering stimulation control system |
| CN109731227A (en) * | 2018-10-23 | 2019-05-10 | 四川大学华西医院 | A kind of system of transcranial magnetic stimulation |
-
2020
- 2020-04-08 CN CN202010282800.2A patent/CN111568372A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093937A (en) * | 1993-03-11 | 1994-10-26 | 乌尔姆技术大学生物医学中央研究所 | The method and apparatus of neuromagnetic stimulation |
| CN103349551A (en) * | 2013-07-08 | 2013-10-16 | 深圳先进技术研究院 | Magnetic resonance elasticity imaging method and system |
| CN105078455A (en) * | 2014-05-15 | 2015-11-25 | 中国科学院上海生命科学研究院 | Functional magnetic resonance imaging synchronous monitoring and triggering stimulation control system |
| CN109731227A (en) * | 2018-10-23 | 2019-05-10 | 四川大学华西医院 | A kind of system of transcranial magnetic stimulation |
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Application publication date: 20200825 |