CN109718670A - One kind cleaning agents of membrane of alkalinity containing enzyme and its application - Google Patents
One kind cleaning agents of membrane of alkalinity containing enzyme and its application Download PDFInfo
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- CN109718670A CN109718670A CN201711051317.8A CN201711051317A CN109718670A CN 109718670 A CN109718670 A CN 109718670A CN 201711051317 A CN201711051317 A CN 201711051317A CN 109718670 A CN109718670 A CN 109718670A
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Abstract
The invention discloses a kind of cleaning agents of membrane of alkalinity containing enzyme and its applications, by forming following weight percentage components: inorganic base 30~50%, surfactant 20~30%, complexing agent 5~10%, builder 10~20%, enzyme preparation 5~10%.Basic enzyme-containing cleaning agents of membrane of the invention can clean the membrane module polluted by various materials, quickly and effectively restore membrane module flux.
Description
Technical field
The invention belongs to Membrane cleaning technical fields, and in particular to one kind cleaning agents of membrane of alkalinity containing enzyme and its application.
Background technique
UF membrane is to use a kind of inorganic or high molecular material with distinctive selectivity separation function as separating layer, in addition
Boundary's energy is motive force, enables a kind of method of each component separation, classification or enrichment in fluid.Membrane technology is led in bio-pharmaceuticals
Domain is widely used, such as various separation of fermentative broth, filtering, the concentration etc. of antibiotic.Membrane technology is also successfully applied to albumen in whey
The recycling of matter, milk deep processing, juice clarification, the extraction of enzyme, vegetable protein recycling, beer residue recycling, liquid glucose concentration etc..Cause
This, UF membrane has unique technological merit as a kind of high-new isolation technics, but in actual process application, concentration difference
Polarization and the big factor of fouling membrane two constrain the popularization and application of membrane technology.Pollution will increase osmotic resistance, and it is logical to reduce film filtering
Amount, and membrane separating property can be made to deteriorate, and then the yield of target product is caused to reduce, increase loss.Simultaneously because film replacement cost
With expensive and Operating Complexity, therefore Membrane cleaning is the important ring in application of membrane.
Membrane separation technique suitable for biofermentation and food service industry has micro-filtration, ultrafiltration, nanofiltration and reverse osmosis, main dirt
Dye object has thallus, albumen, polysaccharide, pigment, salt fouling, amino acid and jelly etc..Pollutant component is complicated, by various
Physics chemical action and film are more closely combined together, and are generated serious fouling membrane, are deteriorated membrane separating property.
Membrane cleaning can be generally divided into physical cleaning, chemical cleaning.Physical cleaning method only can be such that the performance of film obtains
Restore to a certain degree, but the film of physical cleaning its properties after short-term operation are decayed quickly at any time, therefore must be changed
Learn cleaning.The membrane module cleaning that conventional chemical cleaning medicament is gently polluted as although alkali, acid can be used for, but biology is cured
Medicine and the serious fouling membrane of food service industry are difficult to realize the complete recovery of film properties by physical cleaning, and single chemistry is clear
It washes reagent and is also difficult have preferable effect to the combined pollution of heterogeneity, generally require plurality of reagents multi-step and carry out repeatedly
Cleaning, high efficiency at low cost, and the cleaning effect that cannot be satisfied with.For biological medicine and food service industry film application process at
Point complicated the heavy scale pollution, on the market there are no with strong points, cleaning recovery effects are good, and cost is relatively low, and scavenging period is short to answer
The mould assembly cleaning agents of membrane of alkalinity containing enzyme.
Currently, be applied to the conventional cleaning agent of biological medicine and food service industry Membrane cleaning there are the problem of are as follows: 1, reach pre-
When phase effect, cleaning concentration wants high, and scavenging period is long, needs repeated multiple times cleaning, and film device maintenance cost is high.2, biology is cured
The pollution sources specific aim of medicine and food service industry complexity is not strong, and cleaning effect is undesirable, and Membrane cleaning recovery rate is low.3, longer cleaning
When ask and clean recovery rate it is low influence user production cycle and maintenance cost.4, commercially available conventional alkaline cleaning agent often contains
Oxidizing component causes irreversible destruction to membrane modules such as polyamide composite film, cellulose materials, influences film service life.
In this regard, biological medicine and food service industry are a kind of with strong points with needing in technique in film, cleaning recovery effects are good, cost compared with
It is low, to the compound cleaning agents of membrane of alkalinity containing enzyme of film properties safety.
Summary of the invention
The purpose of the present invention is to provide a kind of cleaning agents of membrane of alkalinity containing enzyme.
Another object of the present invention is to provide the preparation methods of the above-mentioned cleaning agents of membrane of alkalinity containing enzyme.
A further object of the present invention is to provide the application methods of the above-mentioned cleaning agents of membrane of alkalinity containing enzyme.
Technical scheme is as follows:
A kind of cleaning agents of membrane of alkalinity containing enzyme, by forming following weight percentage components: inorganic base 30~50%, surface are living
Property agent 20~30%, complexing agent 5~10%, builder 10~20%, enzyme preparation 5~10%；Wherein
Inorganic base is at least one of sodium hydroxide, potassium hydroxide and sodium carbonate；
Surfactant is in neopelex, AEO series of surfactants and TWEEN Series surfactant
At least one；
Complexing agent is EDTA and/or sodium citrate；
The builder is at least one of potassium pyrophosphate, sodium tripolyphosphate and sodium sulphate；
Enzyme preparation is at least one of protease, lipase and amylase.
In a preferred embodiment of the invention, the AEO series of surfactants is AEO-7 or AEO-9.
A kind of preparation method of the above-mentioned cleaning agents of membrane of alkalinity containing enzyme, includes the following steps:
(1) each component is weighed；
(2) component in addition to enzyme preparation is sufficiently mixed uniformly；
(3) enzyme preparation is added in step (2) resulting material while stirring, then contains enzyme after being sieved to get described
Alkaline cleaning agents of membrane.
A kind of application method of the above-mentioned cleaning agents of membrane of alkalinity containing enzyme, is configured to concentration for the cleaning agents of membrane of alkalinity containing enzyme
For the aqueous solution of 0.1~1wt%, it is added in equipment circulation pure water, is adjusted to cleaning solution requirement pH value, then film is cleaned.
In a preferred embodiment of the invention, the concentration of the aqueous solution is 0.3~0.5%, the pH of cleaning solution
=10.5-11.
In a preferred embodiment of the invention, the concentration of the aqueous solution is 0.5~1%, the pH=of cleaning solution
11。
In a preferred embodiment of the invention, the concentration of the aqueous solution is 0.1~0.3%, the pH of cleaning solution
=10.5-11.
The beneficial effects of the present invention are::
1) cleaning concentration is low when alkaline membrane containing enzyme of the invention rinse product industrial application, and dosage is few, film device cleaning
Maintenance cost is low.
2) cleaning agents of membrane of alkalinity containing enzyme of the invention has stronger needle to all kinds of pollutions of biological medicine and food service industry
To property, primary recovery rate of cleaning is high, has comparatively ideal cleaning effect.
3) for product of the present invention in industrial application, one time scavenging period is short, does not influence user's production cycle and arranges.
4) alkaline membrane containing enzyme of the invention rinse product formula does not contain oxidative components, to membrane module chemical safety
It is good.
Specific embodiment
Technical solution of the present invention is further explained and described below by way of specific embodiment.
Embodiment 1
A kind of cleaning agents of membrane of alkalinity containing enzyme, the mass percent of each ingredient are sodium hydroxide 30%, AEO-7 surface-active
Agent 30%, sodium citrate 10%, sodium tripolyphosphate 20%, protease 10%, preparation method is as follows:
(1) each component is weighed；
(2) component in addition to enzyme preparation is sufficiently mixed uniformly；
(3) enzyme preparation is added in step (2) resulting material while stirring, then contains enzyme after being sieved to get described
Alkaline cleaning agents of membrane.
By the above-mentioned cleaning agents of membrane of alkalinity containing enzyme be configured to concentration be 0.3~0.5wt% aqueous solution, then to membrane module into
Row cleaning, specific as follows:
Polluted membrane core used in the present embodiment is the nanofiltration membrane core in erythromycin fermentation liquid, contamination characteristics: under flux
Drop 70%.Embrane method processing is applied to the filtering and concentration of erythromycin fermentation liquid, abomacetin fermentation stage as new separation technology
The metabolin of generation is more, and nanofiltration membrane easily pollutes, and membrane flux reduces, and operating pressure increases, using alkaline cleaner containing enzyme
Cleaning is a kind of effective ways for reducing fouling membrane.
Cleaning step is as follows:
(1) cleaning agent is prepared: deionized water, activation system are added in CIP tank, holding CIP tank liquid level is 2/3 volume,
40 DEG C or so are warming up to, the above-mentioned Membrane cleaning of alkalinity containing enzyme of 0.3~0.5wt% of concentration is pressed according to deionized water volume number in system
The above-mentioned cleaning agents of membrane of alkalinity containing enzyme dissolved is added slowly in CIP purge tank by agent in dissolving completely in keg, is adjusted clear
Stop adding behind pH=10.5~11 of washing lotion stating the cleaning agents of membrane of alkalinity containing enzyme.
(2) it cleans: maintaining 40~50 DEG C of temperature, 6~7bar of pressure is cleaned 45~60 minutes.
(3) it rinses: being 6~7 with the pH value that deionized water is rinsed to water in system.
Final nanofiltration membrane flux recovery rate 99.8%.
Embodiment 2
A kind of cleaning agents of membrane of alkalinity containing enzyme, the mass percent of each ingredient are sodium hydroxide 45%, AEO-9 surface-active
Agent 25%, EDTA10%, potassium pyrophosphate 15%, protease 5%, preparation method is as follows:
(1) each component is weighed；
(2) component in addition to enzyme preparation is sufficiently mixed uniformly；
(3) enzyme preparation is added in step (2) resulting material while stirring, then contains enzyme after being sieved to get described
Alkaline cleaning agents of membrane.
The above-mentioned cleaning agents of membrane of alkalinity containing enzyme is configured to the aqueous solution that concentration is 0.1~0.3wt%, then film core is carried out
Cleaning, specific as follows:
Polluted membrane core used in the present embodiment is the nanofiltration membrane core in gibberellin fermented liquid, contamination characteristics: membrane flux
Quickly, water flux continues to decline after operation for decline, is observed by sampling to film group concentrates at different levels, two groups of film group concentrations after discovery
Occurs sediment in liquid.
Nanofiltration membrane system is used for the concentration after gibberellin fermented liquid ultrafiltration technology, and the universal microbiological contamination of fermentation liquid causes feed liquid to contain
Protein is higher containing sugar, and Membrane cleaning restores difficult, and precipitating can be precipitated in concentration process, the pollution of film is further aggravated for feed liquid,
It is a kind of effective ways for reducing fouling membrane using the cleaning of alkaline cleaner containing enzyme.
Water flux is 8LMH before film core cleans, and nanofiltration membrane flux recovery rate 90.3% after cleaning, cleaning step is as follows:
(1) cleaning agent is prepared: deionized water, activation system are added in CIP tank, holding CIP tank liquid level is 2/3 volume,
40 DEG C or so are warming up to, the above-mentioned alkaline membrane containing enzyme of concentration 0.1~0.3% (W/W) is pressed according to deionized water volume number in system
The above-mentioned nanofiltration of alkalinity containing the enzyme cleaning agents of membrane dissolved is added slowly to CIP purge tank in dissolving completely in keg by cleaning agent
It is interior, it adjusts pH=11 of cleaning solution or so and stops plus stating the cleaning agents of membrane of alkalinity containing enzyme.
(2) it cleans: maintaining 40~50 DEG C of temperature, 6~7bar of pressure is cleaned 45~60 minutes, is not cleared washing lotion and is shut down
Drain is rinsed after impregnating 2 hours.
(3) it rinses: being 6~7 with the pH value that deionized water is rinsed to water in system.
Embodiment 3
A kind of cleaning agents of membrane of alkalinity containing enzyme, the mass percent of each ingredient are sodium carbonate 45%, AEO-9 surfactant
25%, EDTA10%, potassium pyrophosphate 15%, protease 5%, preparation method is as follows:
(1) each component is weighed；
(2) component in addition to enzyme preparation is sufficiently mixed uniformly；
(3) enzyme preparation is added in step (2) resulting material while stirring, then contains enzyme after being sieved to get described
Alkaline cleaning agents of membrane.
The above-mentioned cleaning agents of membrane of alkalinity containing enzyme is configured to the aqueous solution that concentration is 0.5~1wt%, then to rolling ultrafiltration membrane
It is cleaned, specific as follows:
Polluted membrane core used in the present embodiment is the rolling ultrafiltration membrane core in amino acid zymotic fluid, contamination characteristics: film
Flux declines quickly, and water flux continues to decline after operation, is observed by sampling to film group concentrates at different levels, two groups of film groups after discovery
Occurs sediment in concentrate.
Amino acid generallys use fermentation method production, often containing two or more amino acid and polypeptide in system,
Molecular weight is decolourized using rolling ultrafiltration membrane between 100~1000 and removes high molecular weight protein.
Polluted membrane core is controlled pH10.5~11, is controlled 40~45 DEG C of temperature, film using the above cleaning of alkaline cleaner containing enzyme
Water flux is 12LMH, rolling ultrafiltration membrane core filtration flux recovery rate 97.9% after cleaning before core cleans.
Cleaning step is as follows:
(1) cleaning agent is prepared: deionized water, activation system are added in CIP tank, holding CIP tank liquid level is 2/3 volume,
40 DEG C or so are warming up to, the above-mentioned Membrane cleaning of alkalinity containing enzyme of 0.5~1wt% of concentration is pressed according to deionized water volume number in system
The above-mentioned cleaning agents of membrane of alkalinity containing enzyme dissolved is added slowly in CIP purge tank by agent in dissolving completely in keg, is adjusted clear
PH=10.5~11 of washing lotion or so, which stop adding, states the cleaning agents of membrane of alkalinity containing enzyme.
(2) it cleans: maintaining 40~50 DEG C of temperature, 3~5bar of pressure is cleaned 45~60 minutes.
(3) it rinses: being 6~7 with the pH value that deionized water is rinsed to water in system.
The cleaning of table 1 front and back film core flux recovery situation
The foregoing is only a preferred embodiment of the present invention, the range that the present invention that therefore, it cannot be limited according to is implemented, i.e.,
Equivalent changes and modifications made in accordance with the scope of the invention and the contents of the specification should still be within the scope of the present invention.
Claims (7)
1. a kind of cleaning agents of membrane of alkalinity containing enzyme, it is characterised in that: by forming following weight percentage components: inorganic base 30~
50%, surfactant 20~30%, complexing agent 5~10%, builder 10~20%, enzyme preparation 5~10%；Wherein
Inorganic base is at least one of sodium hydroxide, potassium hydroxide and sodium carbonate；
Surfactant be neopelex, AEO series of surfactants and TWEEN Series surfactant in extremely
Few one kind；
Complexing agent is EDTA and/or sodium citrate；
The builder is at least one of potassium pyrophosphate, sodium tripolyphosphate and sodium sulphate；
Enzyme preparation is at least one of protease, lipase and amylase.
2. one kind cleaning agents of membrane of alkalinity containing enzyme as described in claim 1, it is characterised in that: the AEO series of surfactants
For AEO-7 or AEO-9.
3. a kind of preparation method of the cleaning agents of membrane of alkalinity containing enzyme of any of claims 1 or 2, it is characterised in that: including walking as follows
It is rapid:
(1) each component is weighed；
(2) component in addition to enzyme preparation is sufficiently mixed uniformly；
(3) enzyme preparation is added in step (2) resulting material while stirring, it is then alkaline containing enzyme to get described after being sieved
Nanofiltration cleaning agents of membrane.
4. a kind of application method of the cleaning agents of membrane of alkalinity containing enzyme of any of claims 1 or 2, it is characterised in that: contain by described in
Enzyme alkalinity cleaning agents of membrane is configured to the aqueous solution that concentration is 0.1~1wt%, then cleans to nanofiltration membrane.
5. application method as claimed in claim 4, it is characterised in that: the concentration of the aqueous solution is 0.3~0.5%.
6. application method as claimed in claim 4, it is characterised in that: the concentration of the aqueous solution is 0.5~1%.
7. application method as claimed in claim 4, it is characterised in that: the concentration of the aqueous solution is 0.1~0.3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711051317.8A CN109718670A (en) | 2017-10-31 | 2017-10-31 | One kind cleaning agents of membrane of alkalinity containing enzyme and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711051317.8A CN109718670A (en) | 2017-10-31 | 2017-10-31 | One kind cleaning agents of membrane of alkalinity containing enzyme and its application |
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| CN109718670A true CN109718670A (en) | 2019-05-07 |
Family
ID=66293688
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110860210A (en) * | 2019-10-22 | 2020-03-06 | 内蒙古常盛制药有限公司 | Reverse osmosis membrane alkaline cleaning agent and application thereof |
| CN112678918A (en) * | 2020-12-24 | 2021-04-20 | 湖北中泉环保技术有限公司 | Cleaning method of ultrafiltration membrane used for treating soybean processing wastewater |
| CN112877151A (en) * | 2021-04-16 | 2021-06-01 | 厦门市天泉鑫膜科技股份有限公司 | High-efficiency alkaline cleaning agent for landfill leachate pollutants and application thereof |
| CN112999882A (en) * | 2021-04-16 | 2021-06-22 | 厦门市天泉鑫膜科技股份有限公司 | High-efficiency acidic cleaning agent for landfill leachate pollutants and application thereof |
| CN113457457A (en) * | 2021-08-20 | 2021-10-01 | 曜尊饮料(上海)有限公司 | Method for cleaning ultrafiltration membrane used in production process of American ginseng beverage |
| CN113617230A (en) * | 2021-07-28 | 2021-11-09 | 杭州上拓环境科技股份有限公司 | Membrane cleaning agent composition and preparation method and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110860210A (en) * | 2019-10-22 | 2020-03-06 | 内蒙古常盛制药有限公司 | Reverse osmosis membrane alkaline cleaning agent and application thereof |
| CN112678918A (en) * | 2020-12-24 | 2021-04-20 | 湖北中泉环保技术有限公司 | Cleaning method of ultrafiltration membrane used for treating soybean processing wastewater |
| CN112877151A (en) * | 2021-04-16 | 2021-06-01 | 厦门市天泉鑫膜科技股份有限公司 | High-efficiency alkaline cleaning agent for landfill leachate pollutants and application thereof |
| CN112999882A (en) * | 2021-04-16 | 2021-06-22 | 厦门市天泉鑫膜科技股份有限公司 | High-efficiency acidic cleaning agent for landfill leachate pollutants and application thereof |
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| CN113457457A (en) * | 2021-08-20 | 2021-10-01 | 曜尊饮料(上海)有限公司 | Method for cleaning ultrafiltration membrane used in production process of American ginseng beverage |
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