CN109717303A - A kind of preparation method of feed methionine chelate manganese - Google Patents
A kind of preparation method of feed methionine chelate manganese Download PDFInfo
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- CN109717303A CN109717303A CN201711028565.0A CN201711028565A CN109717303A CN 109717303 A CN109717303 A CN 109717303A CN 201711028565 A CN201711028565 A CN 201711028565A CN 109717303 A CN109717303 A CN 109717303A
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- CN
- China
- Prior art keywords
- manganese
- methionine
- dehydrated alcohol
- methionine chelate
- feed
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229930182817 methionine Natural products 0.000 title claims abstract description 42
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title claims abstract description 40
- 239000013522 chelant Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title claims description 19
- 229910052748 manganese Inorganic materials 0.000 title claims description 19
- 239000011572 manganese Substances 0.000 title claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229960000935 dehydrated alcohol Drugs 0.000 claims abstract description 22
- 229940099596 manganese sulfate Drugs 0.000 claims abstract description 20
- 239000011702 manganese sulphate Substances 0.000 claims abstract description 20
- 235000007079 manganese sulphate Nutrition 0.000 claims abstract description 20
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims abstract description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 16
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims abstract description 13
- 238000001035 drying Methods 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 235000011121 sodium hydroxide Nutrition 0.000 claims abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 6
- 238000000926 separation method Methods 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 3
- 239000000376 reactant Substances 0.000 claims description 5
- 230000035484 reaction time Effects 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- KNLQKHUBPCXPQD-UHFFFAOYSA-N manganese;sulfuric acid Chemical compound [Mn].OS(O)(=O)=O KNLQKHUBPCXPQD-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 3
- 102000004190 Enzymes Human genes 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 2
- 239000003674 animal food additive Substances 0.000 abstract description 2
- 235000019629 palatability Nutrition 0.000 abstract description 2
- 230000032258 transport Effects 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 description 8
- 239000000047 product Substances 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 3
- -1 phytate anion Chemical class 0.000 description 3
- 150000003839 salts Chemical group 0.000 description 3
- 241000040710 Chela Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
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- Fodder In General (AREA)
Abstract
The invention discloses a kind of feed preparation method of methionine chelate manganese, this method belongs to feed additive field, and producing the raw material that the product uses includes: methionine, manganese sulfate, 10% sodium hydrate aqueous solution, dehydrated alcohol；Product is made by techniques such as the chelatropic reaction of the production of aqueous solution, methionine and manganese sulfate, separation drying, technological advantage is: industrialized production methionine chelate manganese, simple process, manufacturing cost is low, easy to operate without increasing important equipment, easy to spread；The feed palatability of product configuration is good, and absorptivity is high, easily transports, and can reinforce the activity of enzyme in animal body, the utilization rate of protein, fat and vitamin is improved, to improve the growth performance of animal.
Description
Technical field
The invention belongs to feed additive fields, and in particular to a kind of preparation method of feed methionine chelate manganese.
Background technique
Microelement is one of essential nutrient during growth of animal, and initial microelement is with inorganic salts
Form is introduced directly into feed, such as ferrous sulfate, copper sulphate, although inorganic salts are water-soluble very well, in animal alimentary canal
Inside easily with phytate anion common in feed, oxalate anion by the intracorporal biochemical reaction form of animal formed it is corresponding molten
The salt of solution degree very little, is not easy by intestinal absorption.With the development of feed industry, trace mineral supplement amino-acid trace element is chelating
Object such as amino acid chelated iron, copper amino acid chelate, chelating amino acids manganese and zinc-amino acid chelate etc. is gradually developed, it
Feature is stable, efficient, small toxicity, and absorption easy to digest, is conducive to growth of animal in enteron aisle, can prevent and treat microelement deficiencies
Disease, improves the immunity of organisms of animal, and in feed nutrition composition using beneficial, also have high-protein agent concurrently
Effect.So-called chelate is exactly the complex compound with certain structure type, i.e., ligand can be matched with two or more
Position atom and the same central ion are complexed, and Chelates of Amino Acids And Trace Elements is in divalent metal and amino amino
Nitrogen-atoms formed coordinate bond, it is considered that amino acid is with trophism microelement: iron, copper, manganese, zinc etc. are usually formed ligancy
For 4 chelate, chela number of rings is 2, i.e., the molar ratio of amino acid and microelement is 2:1.The formation of chela ring cause chelating from
Son more difficult fractionation dissociation in aqueous solution than non-chelate ion, Chelates of Amino Acids And Trace Elements is because of its metal ion and amino acid
After molecule is combined by coordinate bond, so that its intramolecular charge is tended to be neutral, form more stable chemical structure, not only stability
Good, good fluidity, antagonism are few, into animal body in after in digestion process impacted factor it is small, convenient for body to metal from
Son is fully absorbed and is utilized, and the present invention is the chelate of methionine and manganese sulfate.
Summary of the invention
Present invention mainly solves the problem of be to provide a kind of chelate with methionine and manganese sulfate, produce the product use
Raw material include: methionine, manganese sulfate, 10% sodium hydrate aqueous solution, dehydrated alcohol.
The present invention can be achieved through the following technical solutions:
A kind of preparation method of feed methionine chelate manganese, it is characterized in that being made of following steps:
(1) methionine: manganese sulfate: 21-23:7:70-72 is sent into chemical reaction kettle to water in molar ratio, and the temperature remains within the normal range, starts and stirs
Device is mixed, monitors pH value at any time, is 7.0-7.2, reaction time 0.8-1.0 hour with 10% sodium hydrate aqueous solution tune pH value.
(2) reactant is sent into centrifugal separator separation, it is methionine chelate manganese and few for removing the solid obtained after moisture removal
The manganese sulfate of amount not chelated, obtains ratio in 1:1 at this time and dehydrated alcohol is added, and does not dissolve in anhydrous second using methionine chelate manganese
Alcohol, and manganese sulfate is dissolved in the principle of dehydrated alcohol, and dehydrated alcohol recycling is filtered off after agitated and is reused, remaining is methionine
Chelated Manganese obtains finished product after methionine chelate manganese is sent into drying machine sealing drying 1.0-1.2 hours.
Methionine purity described in above-mentioned steps (1) is 98%.
The drying temperature of drying machine described in above-mentioned steps (2) is 50 DEG C -60 DEG C.
The beneficial effects of the present invention are:
(1) industrialized production methionine chelate manganese, simple process, manufacturing cost is low, easy to operate without increasing important equipment,
It is easy to spread；
(2) the feed palatability of product configuration is good, and absorptivity is high, easily transports, and can reinforce the activity of enzyme in animal body, improves albumen
The utilization rate of matter, fat and vitamin, to improve the growth performance of animal.
Specific embodiment
Below with reference to specific embodiment, the present invention is described in further detail.
Embodiment 1
Methionine: manganese sulfate: 21:7:72 is sent into chemical reaction kettle to water in molar ratio, and the temperature remains within the normal range, starts blender, at any time
Monitor pH value, with 10% sodium hydrate aqueous solution tune pH value be 7.0, the reaction time 0.8 hour；Reactant is sent into and is centrifugated
Machine separation, removing the solid obtained after moisture removal is methionine chelate manganese and a small amount of manganese sulfate not chelated, must be compared by 1:1 at this time
Dehydrated alcohol is added in example, does not dissolve in dehydrated alcohol using methionine chelate manganese, and manganese sulfate is dissolved in the principle of dehydrated alcohol, through stirring
It filters off dehydrated alcohol recycling after mixing to reuse, remaining is methionine chelate manganese, and methionine chelate manganese is sent into dry secret
Envelope drying obtained finished product after 1.0 hours.
Embodiment 2
Methionine: manganese sulfate: 22:7:71 is sent into chemical reaction kettle to water in molar ratio, and the temperature remains within the normal range, starts blender, at any time
Monitor pH value, with 10% sodium hydrate aqueous solution tune pH value be 7.1, the reaction time 0.9 hour；Reactant is sent into and is centrifugated
Machine separation, removing the solid obtained after moisture removal is methionine chelate manganese and a small amount of manganese sulfate not chelated, must be compared by 1:1 at this time
Dehydrated alcohol is added in example, does not dissolve in dehydrated alcohol using methionine chelate manganese, and manganese sulfate is dissolved in the principle of dehydrated alcohol, through stirring
It filters off dehydrated alcohol recycling after mixing to reuse, remaining is methionine chelate manganese, and methionine chelate manganese is sent into dry secret
Envelope drying obtained finished product after 1.1 hours.
Embodiment 3
Methionine: manganese sulfate: 23:7:70 is sent into chemical reaction kettle to water in molar ratio, and the temperature remains within the normal range, starts blender, at any time
Monitor pH value, with 10% sodium hydrate aqueous solution tune pH value be 7.2, the reaction time 1.0 hours；Reactant is sent into and is centrifugated
Machine separation, removing the solid obtained after moisture removal is methionine chelate manganese and a small amount of manganese sulfate not chelated, must be compared by 1:1 at this time
Dehydrated alcohol is added in example, does not dissolve in dehydrated alcohol using methionine chelate manganese, and manganese sulfate is dissolved in the principle of dehydrated alcohol, through stirring
It filters off dehydrated alcohol recycling after mixing to reuse, remaining is methionine chelate manganese, and methionine chelate manganese is sent into dry secret
Envelope drying obtained finished product after 1.2 hours.
Claims (3)
1. a kind of feed preparation method of methionine chelate manganese, producing the raw material that the product uses includes: methionine, sulfuric acid
Manganese, 10% sodium hydrate aqueous solution, dehydrated alcohol；Its feature the following steps are included:
(1) methionine: manganese sulfate: 21-23:7:70-72 is sent into chemical reaction kettle to water in molar ratio, and the temperature remains within the normal range, starts and stirs
Device is mixed, monitors pH value at any time, is 7.0-7.2, reaction time 0.8-1.0 hour with 10% sodium hydrate aqueous solution tune pH value；
(2) reactant is sent into centrifugal separator separation, it is methionine chelate manganese and a small amount of for removing the solid obtained after moisture removal
The manganese sulfate not chelated obtains ratio in 1:1 at this time and dehydrated alcohol is added, and does not dissolve in dehydrated alcohol using methionine chelate manganese, and
Manganese sulfate is dissolved in the principle of dehydrated alcohol, and dehydrated alcohol recycling is filtered off after agitated and is reused, and remaining is methionine chelate
Manganese obtains finished product after methionine chelate manganese is sent into drying machine sealing drying 1.0-1.2 hours.
2. the preparation method of a kind of feed methionine chelate manganese according to claim 1, it is characterized in that: the egg ammonia
Sour purity is 98%.
3. the preparation method of a kind of feed methionine chelate manganese according to claim 1, it is characterized in that: the drying
The drying temperature of machine is 50 DEG C -60 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711028565.0A CN109717303A (en) | 2017-10-29 | 2017-10-29 | A kind of preparation method of feed methionine chelate manganese |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711028565.0A CN109717303A (en) | 2017-10-29 | 2017-10-29 | A kind of preparation method of feed methionine chelate manganese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109717303A true CN109717303A (en) | 2019-05-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711028565.0A Withdrawn CN109717303A (en) | 2017-10-29 | 2017-10-29 | A kind of preparation method of feed methionine chelate manganese |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109717303A (en) |
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2017
- 2017-10-29 CN CN201711028565.0A patent/CN109717303A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190507 |