CN109709047A - A kind of bimetallic long-range surface plasmon resonance sensor and preparation method thereof - Google Patents
A kind of bimetallic long-range surface plasmon resonance sensor and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of bimetallic long-range surface plasmon resonance sensor and preparation method thereof, for solving the defect that sensor long-time stability are low in the prior art.Bimetallic long-range surface plasmon resonance sensor successively includes basal layer, buffer medium layer, golden adhesion layer, metal function layer, SAM layer, measured medium layer and sample cell；Wherein basal layer is ZF3 glass substrate layers；Buffer medium layer with a thickness of 1 μm；Metal function layer with a thickness of 18 nanometers；SAM layer with a thickness of 10 nanometers；Measured medium layer is deionized water, and sample cell is PDMS sample cell；Measured medium is placed in PDMS sample cell, and SAM layer is placed on measured medium layer.The present invention passes through golden adhesion layer and increases metal function layer and buffer the adhesiveness between dielectric layer, does not influence while enhancing LRSPR sensor stability on its detection sensitivity, improves the practicability of sensor.
Description
Technical field
The present invention relates to sensor and sensor technical fields more particularly to a kind of bimetallic long-range surface plasmon to resonate
Sensor and preparation method thereof.
Background technique
The p- light beam of certain wavelength and incident angle passes through certain coupler (such as prism, waveguide or grating etc.)
Energy is coupled into in a manner of exciting evanescent wave the SPW for being present in interface in metal and medium interface.When metal two sides are situated between
Occur when the refractive index close and thickness of metal film very little of matter layer (i.e. buffer medium layer and detection dielectric layer), such case
The metal membrane SPW that two dielectric surfaces generate simultaneously up and down generates overlapping degeneracy and forms standing wave, and SPW is caused not to be divided into symmetrically and not
Symmetrical both of which, wherein symmetric pattern is since the decaying in communication process is less than dissymmetric mode, thus is known as tying for LRSP
Structure.In this configuration, when energy coupling ratio reaches maximum between light beam and surface plasma-wave, interface reflective light intensity
Occur the spike of strength retrogression on response curve, this phenomenon is known as LRSPR phenomenon, and spike is LRSPR absorption peak, it is corresponding enter
Firing angle degree is LRSPR angle.The change of the neighbouring dielectric thickness in interface or refractive index can cause item when energy coupling ratio maximum
Part changes, and changes so as to cause the movement of LRSPR absorption peak and resonance angle, the scales based on this working principle
For LRSPR sensor.
In LRSPR sensor, for exciting the metal function layer of LRSPR phenomenon to need to prepare on dielectric layer.Currently, often
Dielectric material includes the fluorinated polymer materials such as the inorganic material such as magnesium fluoride and Teflon.It can be on above-mentioned dielectric material
The metal function layers such as gold, silver, copper, iron, aluminium are prepared for exciting LRSPR phenomenon, wherein gold and silver due to biology and chemistry
Material has good compatibility, is to prepare the most common material of LRSPR sensor metal function layer.
Since with good chemical stability and ductility, LRSPR sensor just starts to use from the 1990s
Fluoropolymer is buffer medium layer, and preparation gold is used as metal function layer；LRSPR using gold as metal function layer material is passed
Sensor is lower to the LRSPR angle sensitivity of dielectric thickness near above-mentioned interface or refraction index changing.
The chemical stability of silver is golden slightly lower, therefore usually silver metal function layer surface needs to add protective layer raising
Its stability, silver metal functional layer surface roughness are big.But the angle sensitivity of this LRSPR sensor is than above-mentioned use
Gold is higher as the LRSPR sensor of metal function layer material.In addition, ag material also has at low cost and formation metal function layer
The small advantage of surface roughness.LRSPR sensor using silver as metal function layer material nearby detects Jie to above-mentioned interface
Matter thickness or refraction index changing have preferable sensitivity, and LRSPR sensor just starts using magnesium fluoride from the 1990s
Metal function layer is used as buffer medium layer preparation silver.Using fluoropolymer is buffer medium layer preparation silver as metal function
The LRSPR sensor of layer is studied in 21 century.This LRSPR sensor is in addition to above-mentioned using silver as metal function layer
Other than the advantages of LRSPR sensor, also have the characteristics that surface roughness is low and easy to process, but above-mentioned inorganic material, contains
Fluoropolymer and the adhesion strength of silver metal functional layer are not so good as and golden metal function layer is strong, lead to the long-term of this LRSPR sensor
Stability is lower.
In conclusion being passed using the LRSPR that inorganic material or fluoropolymer prepare silver metal functional layer as buffer medium layer
Sensor has the advantages that easy to process, low in cost, metal function layer surface roughness is small and high sensitivity, but inorganic material
Or fluoropolymer buffer medium layer and the adhesion strength of silver metal functional layer it is weaker, therefore this sensor does not have steadily in the long term
Property.
To sum up, it is necessary to design a kind of bimetallic long-range surface plasmon resonance sensor and preparation method thereof to make up
State defect.
Summary of the invention
The present invention proposes a kind of bimetallic long-range surface plasmon resonance sensor and preparation method thereof, and which solve existing
The low defect of sensor long-time stability in technology.The present invention pass through golden adhesion layer increase metal function layer and buffering dielectric layer it
Between adhesiveness, its detection sensitivity is not influenced while enhancing LRSPR sensor stability, improves sensor
Practicability.
The technical scheme of the present invention is realized as follows:
The present invention discloses a kind of bimetallic long-range surface plasmon resonance sensor, successively includes basal layer, buffering Jie
Matter layer, golden adhesion layer, metal function layer, SAM layer, measured medium layer and sample cell；Wherein basal layer is ZF3 glass substrate layers；
Buffer medium layer with a thickness of 1 μm；Metal function layer with a thickness of 18 nanometers；SAM layer with a thickness of 10 nanometers；Measured medium layer
For deionized water, sample cell is PDMS sample cell；Measured medium is placed in PDMS sample cell, and SAM layer is placed in measured medium layer
On.
Wherein, metal function layer is golden metal function layer or silver metal functional layer.
Wherein, buffer medium layer is magnesium fluoride buffer medium layer or Teflon buffer medium layer.
Wherein, SAM layer is carboxyl-(ethylene glycol)6Mercaptan SAM layer or mercaptoundecylic acid SAM layer.
Invention additionally discloses a kind of preparation methods of bimetallic long-range surface plasmon resonance sensor comprising following step
Rapid: basal layer is cleaned by ultrasonic 2 hours by (S01) by the alcohol-ether mixed liquor that volume ratio is 1:4, is cleaned its surface, is put into
Vacuumizing in electron beam evaporation plating instrument makes atmospheric pressure value be down to 10-6Millitorr；(S02) it is successively deposited with 0.01nm evaporation rate per second
Buffer medium layer and golden adhesion layer；(S03) the evaporation rate evaporation metal functional layer per second with 0.08nm；(S04) by step
(S03) sensor obtained is immersed in carboxyl-(ethylene glycol)6In thiol solution or mercaptoundecylic acid solution, sensed after staying overnight
Device surface forms SAM layer.
Wherein, in step (S04), carboxyl-(ethylene glycol)6The concentration of thiol solution be 1mM, in solvent be wine
Essence；The concentration of mercaptoundecylic acid solution be 1mM, in solvent be alcohol.
Compared with prior art, the present invention has the advantage that
The present invention using SAM layer as metal function layer protective layer and finishing coat, and passes through gold using glass as substrate
Adhesion layer increases metal function layer and buffers the adhesiveness between dielectric layer, while enhancing LRSPR sensor stability pair
Its detection sensitivity does not influence, and improves practicability of the invention.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of one bimetallic long-range surface plasmon resonance sensor of the embodiment of the present invention.
Fig. 2 is Fig. 1 in the resulting LRSPR angle schematic diagram of glycerine water solution measurement for choosing various concentration.
Fig. 3 is the structural schematic diagram of a LRSPR sensor.
Fig. 4 is the structural schematic diagram of another LRSPR sensor.
Fig. 5 is LRSPR angle contrast's schematic diagram that Fig. 1, Fig. 3, Fig. 4 are measured under the same conditions.
Fig. 6 is the structural schematic diagram of two bimetallic long-range surface plasmon resonance sensor of the embodiment of the present invention.
Fig. 7 is the glycerol liquor before bimetallic long-range surface plasmon resonance sensor shown in Fig. 6 shakes in various concentration
The LRSPR angle schematic diagram that solution is calculated as detection dielectric layer.
Fig. 8 is the glycerol liquor after bimetallic long-range surface plasmon resonance sensor shown in Fig. 6 shakes in various concentration
The LRSPR angle schematic diagram that solution is calculated as detection dielectric layer.
Fig. 9 is the structural schematic diagram of the 3rd LRSPR sensor.
Figure 10 is the structural schematic diagram of the 4th LRSPR sensor.
Figure 11 is that the glycerine water solution before the 3rd LRSPR sensor shown in Fig. 9 shakes in various concentration is situated between as detection
The LRSPR angle schematic diagram that matter layer is calculated.
Figure 12 is that the glycerine water solution after the 3rd LRSPR sensor shown in Fig. 9 shakes in various concentration is situated between as detection
The LRSPR angle schematic diagram that matter layer is calculated.
Figure 13 is that the glycerine water solution before the 4th LRSPR sensor shown in Figure 10 shakes in various concentration is situated between as detection
The LRSPR angle schematic diagram that matter layer is calculated.
Figure 14 is that the glycerine water solution after the 4th LRSPR sensor shown in Fig. 9 shakes in various concentration is situated between as detection
The LRSPR angle schematic diagram that matter layer is calculated.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
In order to facilitate and clarify the description of subsequent embodiment, carried out specifically to a specific embodiment of the invention
Before bright, part term is explained, following explanation is applied to this specification and claims.
The LRSPR occurred in the present invention is the abbreviation of Long Range Surface Plasmon Resonance, wherein
The text meaning is that long-range surface plasmon resonates；The LRSP occurred in the present invention is the contracting of Long RangeSurface Plamson
It writes, the Chinese meaning is long-range surface plasmon；The SPW occurred in the present invention is the abbreviation of Surface PlasmonWave,
The Chinese meaning is surface plasma-wave；The SAM occurred in the present invention is the abbreviation of Self-assembled Monolayer, wherein
The text meaning is self-assembled monolayer；The PDMS occurred in the present invention is the abbreviation of polydimethylsiloxane, Chinese
The meaning is dimethyl silicone polymer.The RIU occurred in the present invention is the abbreviation of Refractive Index Unit, Chinese meaning
Think to be refractive index unit.The PBS occurred in the present invention is the abbreviation of phosphate buffer saline, and the Chinese meaning is
Phosphate buffer solution.PBS is typically used as supporting electrolyte.The other English words occurred in the present invention are code, not generation
Table is other in all senses.
Embodiment one
Referring to Fig.1, the present embodiment discloses a kind of bimetallic long-range surface plasmon resonance sensor, successively includes ZF3
Glass substrate layers 1, magnesium fluoride buffer medium layer 2, golden adhesion layer 3, silver metal functional layer 4, carboxyl-(ethylene glycol)6Mercaptan SAM
Layer 5, measured medium layer 6 and sample cell 7；Magnesium fluoride buffer medium layer with a thickness of 1 μm；Golden adhesion layer with a thickness of 10 nanometers；
Silver metal functional layer with a thickness of 18 nanometers；Carboxyl-(ethylene glycol)6Mercaptan SAM layer with a thickness of 10 nanometers；Measured medium layer
For deionized water, sample cell is PDMS sample cell；Measured medium is placed in PDMS sample cell, carboxyl-(ethylene glycol)6Mercaptan
SAM layer is placed on measured medium layer, realizes the function as metal function layer protective layer and finishing coat.
In the present embodiment bimetallic long-range surface plasmon resonance sensor the preparation method is as follows:
ZF3 glass substrate layers are cleaned by ultrasonic 2 hours by the alcohol-ether mixed liquor that volume ratio is 1:4, clean its table
Being put into vacuumize in electron beam evaporation plating instrument behind face makes atmospheric pressure value be down to 10-6Millitorr；Successively with evaporation rate 0.01nm per second
Magnesium fluoride buffer medium layer and golden adhesion layer is deposited, silver metal functional layer is then deposited with evaporation rate 0.08nm per second, is obtained
To sensor；Sensor is finally immersed in carboxyl-(ethylene glycol)6SAM layer is formed in thiol solution overnight, wherein carboxyl-
(ethylene glycol)6The concentration of mercaptan is 1mM, and solvent is alcohol, is placed on PDMS sample cell as measured medium using deionized water
In.
Referring to Fig. 2, chosen under conditions of incident light beam wavelength is 660nm using ZF3 glass prism as coupler
The glycerine water solution of various concentration measures the LRSPR angle calculation of the resonance sensor of bimetallic long-range surface plasmon shown in Fig. 1
Sensitivity.Solid line shown in Fig. 2 is that bimetallic long-range surface plasmon resonance sensor shown in Fig. 1 is water-soluble in the glycerol of various concentration
The LRSPR angle that liquid is calculated as detection dielectric layer is maintained at the LRSPR angle sensitivity of detection dielectric layer
27.60°/RIU。
The advantages of for convenient for prominent the present embodiment, it successively includes glass substrate layers that Fig. 3, which show a LRSPR sensor,
1a, magnesium fluoride buffer medium layer 2a, silver metal functional layer 4a, SAM layer 5a, measured medium layer 6a and sample cell 7a, magnesium fluoride are slow
Rush dielectric layer with a thickness of 1 μm, silver metal functional layer with a thickness of 18nm；Fig. 4 show another LRSPR sensor, successively
Including glass substrate layers 1b, magnesium fluoride buffer medium layer 2b, golden metal function layer 4b, SAM layer 5b, measured medium layer 6b and sample
Pond 7b, magnesium fluoride buffer medium layer with a thickness of 1 μm, golden metal function layer with a thickness of 18nm.
LRSPR sensor shown in Fig. 3 and Fig. 4 the preparation method comprises the following steps: by glass substrate layers by volume ratio be 1:4 second
Alcohol-ether mixed liquor is cleaned by ultrasonic 2 hours, and cleaning to be put into vacuumize in electron beam evaporation plating instrument behind its surface is down to atmospheric pressure value
10-6Millitorr.Above-mentioned magnesium fluoride buffer medium layer and the evaporation rate of golden metal function layer are that 0.01nm is per second, silver metal functional layer
Evaporation rate be 0.08nm it is per second.The preparation method and embodiment one of SAM layer and sample cell is consistent.
Referring to Fig. 5, chosen under conditions of incident light beam wavelength is 660nm using ZF3 glass prism as coupler
The glycerine water solution of various concentration measures the LRSPR angle calculation sensitivity of LRSPR sensor shown in Fig. 1, Fig. 3 and Fig. 5.Fig. 5
Intermediate cam shape icon is for bimetallic long-range surface plasmon resonance sensor shown in Fig. 1 in various concentration glycerine water solution as inspection
The LRSPR angle that dielectric layer is calculated is surveyed, 27.6 °/RIU is maintained to the LRSPR angle sensitivity of detection dielectric layer；It is square
Shape icon is for bimetallic long-range surface plasmon resonance sensor shown in Fig. 3 in various concentration glycerine water solution as detection medium
The LRSPR angle that layer is calculated is maintained at 20.17 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.Round icon
For sensor structure shown in Fig. 4 in various concentration glycerine water solution as the LRSPR angle that is calculated of detection dielectric layer, to inspection
The LRSPR angle sensitivity for surveying dielectric layer is maintained at 18.07 °/RIU.
As seen from the above comparison, the bimetallic long-range metal surface plasma sensor of the embodiment of the present invention one is in glycerol
Under aqueous environment, sensitivity is more stable.
Embodiment two
Referring to Fig. 6, it successively includes ZF3 that the present embodiment, which discloses a kind of bimetallic long-range surface plasmon resonance sensor,
Glass substrate layers 11, Teflon buffer medium layer 12, golden adhesion layer 13, silver metal functional layer 14, golden metal function layer protective layer
15, mercaptoundecylic acid SAM layer 16, measured medium layer 17 and sample cell 18；Teflon buffer medium layer with a thickness of 1 μm；Gold is viscous
Attached layer with a thickness of 10 nanometers；Silver metal functional layer with a thickness of 18 nanometers；Golden metal function layer protective layer is received with a thickness of 2
Rice；Mercaptoundecylic acid SAM layer is as finishing coat and bio-molecule layer；Measured medium layer is deionized water, and sample cell is
PDMS sample cell；Measured medium is placed in PDMS sample cell, and mercaptoundecylic acid SAM layer is placed on measured medium layer.
In the present embodiment bimetallic long-range surface plasmon resonance sensor the preparation method is as follows:
ZF3 glass substrate layers are cleaned by ultrasonic 2 hours by the alcohol-ether mixed liquor that volume ratio is 1:4, clean its table
Behind face, made with being put into vacuumize in electron beam evaporation plating instrument after 3500 revs/min of revolving speed rotary coating Teflon buffer medium layer
Atmospheric pressure value is down to 10-6Millitorr；Golden adhesion layer is deposited with evaporation rate 0.01nm per second, then the vapor deposition speed per second with 0.08nm
Silver metal functional layer is deposited in rate, then golden metal function layer protective layer is deposited with evaporation rate 0.01nm per second, obtains sensor；
Finally sensor is immersed in mercaptoundecylic acid solution and forms SAM layer overnight, wherein the concentration of mercaptoundecylic acid is 1mM, molten
Agent is alcohol.
Bimetallic long-range surface plasmon resonance sensor shown in fig. 6 is immersed in the PBS solution of 0.01M concentration,
12 hours front and backs are shaken on shaking table oscillator using 2000 revs/min of concussion speed, ZF3 glass prism is respectively adopted as coupling
Clutch, under conditions of incident light beam wavelength is 660nm, the glycerine water solution for choosing various concentration measures bimetallic shown in Fig. 6
The LRSPR angle calculation sensitivity of long-range surface plasmon resonance sensor.As shown in fig. 7, solid line is that bimetallic shown in Fig. 6 is long
It is calculated in the glycerine water solution of various concentration as detection dielectric layer before the concussion of journey surface plasma resonance sensor
LRSPR angle is maintained at 30.30 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.As shown in figure 8, solid line is Fig. 6 institute
Show after bimetallic long-range surface plasmon resonance sensor shakes in the glycerine water solution of various concentration as detection dielectric layer
The LRSPR angle being calculated is maintained at 30.32 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.
The advantages of for convenient for prominent the present embodiment, Fig. 9 show the 3rd LRSPR sensor, successively includes substrate of glass
Layer 11a, Teflon buffer medium layer 12a, silver metal functional layer 14a, SAM layer 15a, measured medium layer 16a and sample cell (are not schemed
Show), Teflon buffer medium layer with a thickness of 1 μm, silver metal functional layer with a thickness of 18nm；Figure 10 show the 4th LRSPR
Sensor, successively include glass substrate layers 11b, Teflon buffer medium layer 12b, golden metal function layer 14b, SAM layer 15b,
Measured medium layer 16b and sample cell (not shown), Teflon buffer medium layer with a thickness of 1 μm, the thickness of golden metal function layer
For 18nm.
LRSPR sensor shown in Fig. 9 and Figure 10 the preparation method comprises the following steps: by glass substrate layers by volume ratio be 1:4 second
Alcohol-ether mixed liquor is cleaned by ultrasonic 2 hours clean surfaces, with 3500 revs/min of revolving speed rotary coating Teflon buffer medium layer
After be put into vacuumize in electron beam evaporation plating instrument atmospheric pressure value made to be down to 10-6Millitorr；It is above-mentioned gold metal function layer evaporation rate be
0.01nm is per second, and the evaporation rate of silver metal functional layer is that 0.08nm is per second.The preparation method of SAM layer is consistent with embodiment two.
LRSPR sensor shown in Fig. 9 and Figure 10 is separately immersed in the PBS solution of 0.01M concentration, using 2000 turns/
The concussion speed divided shakes 12 hours front and backs on shaking table oscillator and ZF3 glass prism is respectively adopted as coupler, in incidence
Under conditions of light beam wavelength is 660nm, the glycerine water solution for choosing various concentration measures LRSPR sensor shown in Fig. 9 and Figure 10
LRSPR angle calculation sensitivity.Solid line shown in Figure 11 is before LRSPR sensor shown in Fig. 9 shakes in the sweet of various concentration
The LRSPR angle that oil solution is calculated as detection dielectric layer is maintained at the LRSPR angle sensitivity of detection dielectric layer
20.17°/RIU.Solid line shown in Figure 12 is the glycerine water solution conduct after LRSPR sensor shown in Fig. 9 shakes in various concentration
The LRSPR angle that detection dielectric layer is calculated is maintained at 18.00 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.
Solid line shown in Figure 13 is in the glycerine water solution of various concentration before LRSPR sensor shown in Figure 10 shakes as detection dielectric layer
The LRSPR angle being calculated is maintained at 18.07 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.It is real shown in Figure 14
Line is to be calculated in the glycerine water solution of various concentration as detection dielectric layer after LRSPR sensor shown in Figure 10 shakes
LRSPR angle is maintained at 17.97 °/RIU to the LRSPR angle sensitivity of detection dielectric layer.
As seen from the above comparison, the bimetallic long-range metal surface plasma sensor of the embodiment of the present invention two is molten in salt
Under pendular ring border, sensitivity is more stable.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of bimetallic long-range surface plasmon resonance sensor, which is characterized in that it successively includes basal layer, buffer medium
Layer, golden adhesion layer, metal function layer, SAM layer, measured medium layer and sample cell；Wherein basal layer is ZF3 glass substrate layers；It is slow
Rush dielectric layer with a thickness of 1 micron；Golden adhesion layer with a thickness of 10 nanometers；Metal function layer with a thickness of 18 nanometers；SAM layer
With a thickness of 10 nanometers；Measured medium layer is deionized water, and sample cell is PDMS sample cell；Measured medium is placed on PDMS sample cell
In, SAM layer is placed on measured medium layer.
2. bimetallic long-range surface plasmon resonance sensor as described in claim 1, which is characterized in that metal function layer is
Golden metal function layer or silver metal functional layer.
3. bimetallic long-range surface plasmon resonance sensor as claimed in claim 1 or 2, which is characterized in that buffer medium
Layer is magnesium fluoride buffer medium layer or Teflon buffer medium layer.
4. bimetallic long-range surface plasmon resonance sensor as claimed in claim 3, which is characterized in that SAM layer is carboxyl-
(ethylene glycol)6Mercaptan SAM layer or mercaptoundecylic acid SAM layer.
5. a kind of preparation side of such as bimetallic long-range surface plasmon resonance sensor of any of claims 1-4
Method, which is characterized in that it includes the following steps:
(S01) basal layer is cleaned by ultrasonic 2 hours by the alcohol-ether mixed liquor that volume ratio is 1:4, cleans its surface, puts
Entering to vacuumize in electron beam evaporation plating instrument makes atmospheric pressure value be down to 10-6Millitorr；
(S02) buffer medium layer and golden adhesion layer are deposited successively with evaporation rate 0.01nm per second；
(S03) the evaporation rate evaporation metal functional layer per second with 0.08nm；
(S04) sensor that step (S03) obtains is immersed in carboxyl-(ethylene glycol)6Thiol solution or mercaptoundecylic acid solution
In, SAM layer is formed in sensor surface after staying overnight.
6. the preparation method of bimetallic long-range surface plasmon resonance sensor as claimed in claim 5, which is characterized in that step
Suddenly in (S04), carboxyl-(ethylene glycol)6The concentration of thiol solution be 1mM, in solvent be alcohol.
7. the preparation method of bimetallic long-range surface plasmon resonance sensor as claimed in claim 5, which is characterized in that step
Suddenly in (S04), the concentration of mercaptoundecylic acid solution is 1mM, in solvent be alcohol.
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| CN110346333A (en) * | 2019-08-07 | 2019-10-18 | 东北大学 | A kind of LRSPR high sensitivity optical fiber sensor |
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Application publication date: 20190503 |