CN109700758A - DM Cough and preparation method thereof - Google Patents
DM Cough and preparation method thereof Download PDFInfo
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- CN109700758A CN109700758A CN201910079779.3A CN201910079779A CN109700758A CN 109700758 A CN109700758 A CN 109700758A CN 201910079779 A CN201910079779 A CN 201910079779A CN 109700758 A CN109700758 A CN 109700758A
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Abstract
The invention discloses a kind of DM Cough agent and preparation method thereof, preparation method key step include: first by sucrose dissolution be made after syrup boiled with ethyl hydroxy benzoate it is spare, light caramel boils spare, dextromethorphan hydrobromide, menthol, strawberry essence are added spare in ethanol solution, after filtering, syrup, ethyl hydroxy benzoate, light caramel and dextromethorphan hydrobromide, menthol, strawberry essence are added in make-up tank, cooling water is being added, stirring, obtains DM Cough.Syrup clinical application antibechic significant effect is prepared in the present invention, adverse reaction rate is low, clinical application is extremely safe, and technique adds sucrose as auxiliary material in preparation method, mouthfeel can be improved, and there is good adhesive force, while the technology controlling and process promise of each step stability of product.
Description
Technical field
The present invention relates to a kind of dextromethorphan hydrobromide of the preparation technique field of drug more particularly to town phlegm and relieving cough sugar
Slurry and preparation method thereof.
Background technique
Flu is the infection of the upper respiratory tract as caused by a variety of viruses, is commonly called as " catching cold ", is generable common to exhale in the four seasons
Inhale tract disease.It can cause complication such as viral pneumonia, the heart if controlling not in time with extensive popular and infectiousness
Myositis etc. seriously endangers human health.It is divided into common cold and influenza on cold clinical again.Bronchitis is in winter
Common complaint among the elderly.It mostly cures and changes not in time because of acute bronchitis.According to statistics, China 50 years old or more middle-aged and the old
Disease incidence is 15%~30% or so.Clinically often show as cough, expectoration, or with shortness of breath, wheeze, serious person can be concurrent
Pulmonary emphysema, pulmonary heart disease etc. have seriously affected the work and life of people.
The symptom of flu and bronchitis is mostly to cough, cough up phlegm as cardinal symptom.Cough is that respiratory system is stimulated
When a kind of generated defensive reflex activity, phlegm is the product of respiratory inflammation, respiratory mucosa can be stimulated to cause to cough, and
Aggravate infection.Therefore, it is necessary to using antisussive and expectorant agent to alleviate the state of an illness.
Dextromethorphan hydrobromide is central antitussive object, can inhibit brain coughing centre two and generates antitussive effect.Peppermint is used
In headache and nasopharynx laryngitis.Its mechanism of action is by blocking the reflection of coughing centre to improve central nervous system cough threshold
Value and play antitussive effect, act on, but analgesia and sedation without codeine suitable with codeine phosphate, and it is additive compared with
Low, therapeutic dose will not inhibit respiratory center and respiratory mucosa to secrete, and clinical application antibechic significant effect, adverse reaction occurs
Rate is low, and clinical application is extremely safe；But preparation process is complicated at present, step is various, big to the dependence in equipment and place.
Summary of the invention
In order to overcome the defect that preparation process in the prior art is complicated, step is various, big to the dependence of equipment and place, one
Aspect, the embodiment of the invention provides a kind of preparation method of DM Cough, the preparation method includes following
Step:
S1, sucrose is first dissolved into initial syrup in purified water；
Ethyl hydroxy benzoate is added in S2, the initial syrup made from S1, boils dissolution；The first filtrate is obtained by filtration, it will be described
First filtrate, which flows into, matches tubbing；
S3, dissolution is boiled into the heating of light caramel, the second filtrate is obtained by filtration, by configuration bucket described in the second filtrate and the first filter
Liquid mixing；
S4, dextromethorphan hydrobromide, menthol, strawberry essence are dissolved in ethanol, third filtrate is obtained by filtration, by institute
It states in the mixed solution that third filtrate is added in S3, stir and is uniformly mixed it, the first mixing molasses are prepared；
S5,45 DEG C are cooled to mixing molasses made from S4 hereinafter, the 4th filtrate is obtained by filtration, by the 4th filtrate inflow institute
It states with tubbing；
S6, add in the configuration bucket such as cooling water, constant volume, obtained second mixing molasses；
S7, stirring second mixing molasses and filling, are made syrup.
Wherein, in the step S7 syrup include following weight component:
As the further improvement of embodiment of the present invention, syrup further includes citric acid in the step S7, the lemon
The parts by weight of lemon acid are 0.1-10.
As the further improvement of embodiment of the present invention, syrup includes following weight in the step S7
Component:
On the other hand, it the embodiment of the invention also discloses a kind of DM Cough agent, is prepared by the above method
It obtains.
The invention has the following advantages: hydrobromic acid is right after sucrose, menthol, strawberry essence is added in syrup
The bitter taste of dextromethorphan is blanked, and reduces bitter taste, reduces the application of aromatic；The present invention improves the stability of syrup especially
It is the stability of solution colour and color；Simultaneously in terms for the treatment of flu and bronchitis lead to the effect of cough, the present invention is multiple
The relatively existing compound DM Cough agent of square DM Cough agent achieves more preferable effect.
Detailed description of the invention
The drawings described herein are used to provide a further understanding of the present application, constitutes part of this application, this Shen
Exemplary embodiment and its explanation please is not constituted an undue limitation on the present application for explaining the application；Wherein:
Fig. 1 is the preparation method flow diagram of the DM Cough in embodiment 1.
Specific embodiment
Embodiment 1
The embodiment of the invention provides a kind of preparation methods of DM Cough, comprising the following steps:
S1, sucrose is first dissolved into initial syrup in purified water；
Ethyl hydroxy benzoate is added in S2, the initial syrup made from S1, boils dissolution；The first filtrate is obtained by filtration, it will be described
First filtrate, which flows into, matches tubbing；
S3, dissolution is boiled into the heating of light caramel, the second filtrate is obtained by filtration, by configuration bucket described in the second filtrate and the first filter
Liquid mixing；
S4, dextromethorphan hydrobromide, menthol, strawberry essence are dissolved in ethanol, third filtrate is obtained by filtration, by institute
It states in the mixed solution that third filtrate is added in S3, stir and is uniformly mixed it, the first mixing molasses are prepared；
S5,45 DEG C are cooled to mixing molasses made from S4 hereinafter, the 4th filtrate is obtained by filtration, by the 4th filtrate inflow institute
It states with tubbing；
S6, add in the configuration bucket such as cooling water, constant volume, obtained second mixing molasses；
S7, stirring second mixing molasses and filling, are made syrup.
Wherein, in the step S7 syrup include following weight component:
In embodiments of the present invention, syrup includes the component of following weight:
Concrete operations are as follows:
500g sucrose is weighed, 500g purified water is added, oxybenzene ethyl alcohol is then added, boils after making dissolution, light caramel is added
1g boils, and filtering is let cool to 40 DEG C；The dextromethorphan hydrobromide and 1g menthol and strawberry essence for weighing 1g, with the ethyl alcohol of 10g
Stirring and dissolving is added 70 DEG C of water and is sufficiently stirred, and filtrate is added in above-mentioned syrup after cooling, keeps medical fluid relatively close at 25 DEG C
Degree 1.08；Syrup is heated to 50 DEG C, suitable 50 DEG C of warm water and 1g citric acid is added, stirs evenly, is cooled to 45 to fluid temperature
DEG C or less filter after the assay was approved, filtrate be DM Cough agent.
Embodiment 2
The embodiment of the invention also discloses a kind of DM Cough agent, are prepared by method in embodiment 1.
Syrup includes the component of following weight:
In embodiments of the present invention, syrup includes the component of following weight:
It joined menthol and strawberry essence in the formula of syrup, menthol is a kind of left-handed colorless needle crystals, molten
In ethyl alcohol, dissolve each other with oils.With cool, clear fresh, pleasant peppermint characteristic perfume, the spine gas with sweet tea gives cold
Feel, fragrance is sent out thoroughly, but not enough persistently.Taste is also the cool taste of fresh sweetness.
The invention has the following advantages: the bitter taste of dextromethorphan hydrobromide is covered after sucrose is added in syrup
Lid, reduces bitter taste, reduces the application of aromatic；The present invention improves the stability especially solution colour and color of syrup
Stability；Simultaneously in terms for the treatment of flu and bronchitis lead to the effect of cough, compound dextromethorphan hydrobromide of the present invention
The relatively existing compound DM Cough agent of syrup achieves more preferable effect.
Claims (5)
1. a kind of preparation method of DM Cough agent, which is characterized in that the preparation method comprises the following steps:
S1, sucrose is first dissolved into initial syrup in purified water；
Ethyl hydroxy benzoate is added in S2, the initial syrup made from S1, boils dissolution；The first filtrate is obtained by filtration, by described first
Filtrate, which flows into, matches tubbing；
S3, dissolution is boiled into the heating of light caramel, the second filtrate is obtained by filtration, configuration bucket described in the second filtrate is mixed with the first filtrate
It closes；
S4, dextromethorphan hydrobromide, menthol, strawberry essence are dissolved in ethanol, third filtrate is obtained by filtration, by described
Three filtrates are added in the mixed solution in S3, stir and are uniformly mixed it, the first mixing molasses are prepared；
S5,45 DEG C are cooled to mixing molasses made from S4 hereinafter, the 4th filtrate is obtained by filtration, will the 4th filtrate flow into described in match
Tubbing；
S6, add in the configuration bucket such as cooling water, constant volume, obtained second mixing molasses；
S7, stirring second mixing molasses and filling, are made syrup.
2. the preparation method of DM Cough agent as described in claim 1, which is characterized in that in the step S7
Syrup includes the component of following weight:
3. the preparation method of DM Cough agent as described in claim 1, which is characterized in that in the step S7
Syrup further includes citric acid, and the parts by weight of the citric acid are 0.1-10.
4. the preparation method of DM Cough agent as described in claim 1, which is characterized in that in the step S7
Syrup includes the component of following weight: dextromethorphan hydrobromide 3, menthol 1, strawberry essence 1, ethyl hydroxy benzoate 20,
Sucrose 600, ethyl alcohol 10, water 1000, light caramel 2.
5. a kind of DM Cough agent, which is characterized in that the preparation method as described in claim 1-4 any one
It is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910079779.3A CN109700758A (en) | 2019-01-28 | 2019-01-28 | DM Cough and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910079779.3A CN109700758A (en) | 2019-01-28 | 2019-01-28 | DM Cough and preparation method thereof |
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| Publication Number | Publication Date |
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| CN109700758A true CN109700758A (en) | 2019-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910079779.3A Pending CN109700758A (en) | 2019-01-28 | 2019-01-28 | DM Cough and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63313725A (en) * | 1987-06-17 | 1988-12-21 | Kowa Co | Syrup agent |
| CN101904850A (en) * | 2010-08-17 | 2010-12-08 | 程雪翔 | Medicament for relieving cough and removing sputum and preparation method for syrup thereof |
| CN102600210A (en) * | 2012-04-10 | 2012-07-25 | 湖北凤凰白云山药业有限公司 | Compound dextromethorphan hydrobromide syrup and preparation method for same |
-
2019
- 2019-01-28 CN CN201910079779.3A patent/CN109700758A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63313725A (en) * | 1987-06-17 | 1988-12-21 | Kowa Co | Syrup agent |
| CN101904850A (en) * | 2010-08-17 | 2010-12-08 | 程雪翔 | Medicament for relieving cough and removing sputum and preparation method for syrup thereof |
| CN102600210A (en) * | 2012-04-10 | 2012-07-25 | 湖北凤凰白云山药业有限公司 | Compound dextromethorphan hydrobromide syrup and preparation method for same |
Non-Patent Citations (2)
| Title |
|---|
| 梁发华: "橘子香味右美沙芬糖浆的制备和临床应用", 《中国医药导报》 * |
| 陈鸿标: "氢溴酸右美沙芬糖浆的研制", 《中国药业》 * |
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Application publication date: 20190503 |
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