CN109692008A - Muscle oxygen based on NIRS technology closes detection device - Google Patents
Muscle oxygen based on NIRS technology closes detection device Download PDFInfo
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- CN109692008A CN109692008A CN201811506577.4A CN201811506577A CN109692008A CN 109692008 A CN109692008 A CN 109692008A CN 201811506577 A CN201811506577 A CN 201811506577A CN 109692008 A CN109692008 A CN 109692008A
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- microprocessor
- receiving end
- near infrared
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
Abstract
The embodiment of the invention discloses a kind of, and the muscle oxygen based on NIRS technology closes detection device, comprising: electrode, light source, nearside receiving end, distal side receiving end, temperature sensor, microprocessor, power supply.Oxygen based on near-infrared spectrum technique proposed by the invention, which closes equipment, has the characteristics that small in size, control is simple, performance is stable.
Description
Technical field
The present invention relates to biomedical engineering technology field, in particular to a kind of muscle oxygen based on NIRS technology closes detection
Equipment.
Background technique
Studies have shown that hemoglobin is the main carriers of tissue oxygen, by oxyhemoglobin (HbO2) and reduced blood
Lactoferrin (Hb) composition, the oxygen in tissue be substantially in the form of oxyhemoglobin in organize in capillary existing for.
Blood oxygen saturation refers to the percentage of HbO2 content in hemoglobin (i.e. the sum of HbO2 and Hb concentration), as human body has oxo
Thank to the variation of situation, blood oxygen saturation can change.
The oxygen saturation of tissue is the blood oxygen saturation of each autoblood in arteriole in tested tissue, venule and capillary
The weighted average of degree；Since the flow velocity of venule blood is relatively slow, in blood oxygen saturation in the highest flight.Tissue
Blood oxygen saturation can reflect the dynamic equilibrium of local organization oxygen supply and oxygen consumption, have important meaning in training monitoring
Justice.
Clinically it is mostly used the blood oxygen parameter of two methods detection blood.First is that invasive blood gas analysis, i.e., from the big blood of human body
(artery or vein) blood drawing is managed, obtains its blood oxygen parameter with biochemical method.Second is that detection finger tip detecting sphygmus and blood oxygen saturation, this is nothing
The optical detecting method of wound, sensor are clipped in finger tip, beating of the testing principle based on finger tip artery extracts and decay through finger tip
Emergent light exchange (beating) component and carry out calculating acquisition.Therefore blood oxygen saturation is actually the oxygen saturation of arterial blood
Degree, as long as the oxygen supply of human body finger tip artery is normal, normally close to 100%.
Near infrared spectrum (near infrared spectroscopy, NIRS) technology has become biomedical important point
Branch.Near infrared light has good penetrability to tissue, research shows thatWave band HbO2 and Hb are tissues
In main absorber.Therefore near infrared light (the several mW of light intensity) is incident on human tissue surface, detects a certain position
Decaying of the emergent light relative to incident light, so that it may obtain tissue oxygenation situation for information about.Above-mentioned detection is lossless, real
When, it is continuous, this is exactly the outstanding advantages of near infrared spectrum (NIRS).
Near infrared spectrum (NIRS) technology can be used for studying and detecting the concentration of internal photoactive substance.The near-infrared emitted
Light irradiates skin and subcutaneous target organ-tissue, and some of light inhale the sensitive biochemistry extinction component of near infrared spectrum
It receives, is scattered without absorbed light.Every kind of biochemical composition has different absorption spectrums, by measuring across organ group
The near-infrared optical feature knitted can determine the concentration or variable quantity of biochemical composition photosensitive in tissue.
Near infrared spectrum (NIRS) detection technique is in the quality control of chemistry and biology research, food and drug and doctor
It is widely used in the fields such as instrument and equipment for the treatment of.Application of the NIRS in medical instrument includes photosensitive object in detectable substance organ-tissue
The concentration and its variable quantity or trend and Tissue Blood oxygen saturation conditions of matter diagnose physiology for non-invasive methods and metabolic disease provide
Clinical foundation.NIRS is successfully used for the research of big cerebral blood oxygen saturation detection and urodynamics, is also used for research skeletal muscle and fills
Infuse oxygen saturation, breast tissue tumor, cutaneum carcinoma, lymph cancer etc..
The specific algorithm of near infrared spectrum (NIRS) detection tissue oxygenation has following three kinds.First is that continuous wave (CW) side
Method uses the incident light of constant intensity at this time, and the light intensity attenuation by detection emergent light relative to incident light obtains the blood of tissue
Oxygen parameter.Second is that phase-modulation (PMS) method, incident light is the sine wave of high frequency (100-200MHZ) at this time, by detecting
Strength retrogression of the light with respect to incident light and phase delay are penetrated, the blood oxygen parameter of tissue is obtained.Third is that time resolved spectroscopy (TRS) side
Method, incident light is a ultrashort pulse (pulsewidth is ps magnitude) at this time, by detecting the time response of emergent light, obtains tissue
Blood oxygen parameter.Continuous wave (CW) method is easiest to realize, clinical application is the most extensive, and phase-modulation (PMS) and time resolution
Spectrum (TRS) method realizes relative difficulty.Inventor it has been investigated that, answered currently near infrared light measurement tissue oxygen content
With also fewer.
Summary of the invention
Based on this, the technical issues of to solve in the prior art, spy proposes a kind of muscle oxygen based on NIRS technology and closes
Detection device, comprising:
Electrode, light source, nearside receiving end, distal side receiving end, temperature sensor, microprocessor, power supply；
In one embodiment, the light source is transmitting terminal LED；What the transmitting terminal LED was controlled in the microprocessor
Driving circuit driving is lower to emit near infrared light；
Wherein, distance is different between the nearside receiving end and the distal side receiving end and the light source；The nearside connects
Receiving end and the distal side receiving end all include near infrared light spectrum sensor；The near infrared light spectrum sensor of the nearside receiving end and
The near infrared light spectrum sensor and the microprocessor of the distal side receiving end are connected with each other；By the near infrared light spectrum sensor
Measurement obtains blood oxygen saturation and hemoglobin concentration and is transmitted to the microprocessor；
Wherein, the temperature sensor is connected to the microprocessor, and the temperature sensor real-time detection temperature simultaneously will
The temperature data of acquisition is sent to the microprocessor；The microprocessor calculates temperature-compensating according to the temperature data received
Data；
The microprocessor calculates the data received, analysis is handled；
In one embodiment, the microprocessor includes memory, USB interface；Wherein, the USB interface be used for
Data, including upload or downloading data are transmitted between external equipment；The memory is for storing the data received；
In one embodiment, it includes communication module that the oxygen based on near-infrared spectrum technique, which closes equipment,；The communication
Module is connected to the microprocessor, and the communication module transmits data to external equipment；
In one embodiment, the external equipment includes mobile phone, computer, PDA；The communication module and outside
It is communicated between equipment using bluetooth, WIFI.
Implement the embodiment of the present invention, will have the following beneficial effects:
Technical solution of the present invention is using near-infrared spectrum technique to the blood oxygen saturation and hemoglobin in tissue
Concentration carries out real-time, continuous, non-destructive testing and the real-time Transmission to testing result, proposed by the invention based near infrared spectrum
The oxygen of technology, which closes equipment, has the characteristics that small in size, control is simple, performance is stable.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Wherein:
Fig. 1 is that the muscle oxygen in the present invention based on NIRS technology closes detection device schematic diagram.
Fig. 2 is contrast schematic diagram before and after near infrared spectrum sensor voltage temperature-compensating under stationary state in the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The present invention provides a kind of muscle oxygen conjunction detection device based on NIRS technology.
Fig. 1 show the oxygen for being based near infrared spectrum (near infrared spectroscopy, NIRS) technology
Close equipment schematic diagram；The oxygen close equipment include electrode 1, light source 2, nearside receiving end 3, distal side receiving end 4, temperature sensor 5,
Microprocessor (not shown), power supply (not shown), communication module (not shown).
Wherein, the light source 2 is transmitting terminal LED；The transmitting terminal LED drives in the driving circuit that the microprocessor controls
Dynamic lower transmitting near infrared light；
Wherein, in order to obtaining blood oxygen saturation (S in real timeVO2), introduce the near infrared light based on spatial resolution
(NIRS) technology of composing, uses two receiving ends different from the light source distance, including nearside receiving end 3, distal side receiving end 4；
The nearside receiving end and the distal side receiving end all include near infrared spectrum (NIRS) sensor, as shown in Figure 1,
As the near infrared light spectrum sensor of nearside receiving end, distal side receiving end near infrared light spectrum sensor；The nearside receiving end
Near infrared light spectrum sensor and the distal side receiving end near infrared light spectrum sensor and the microprocessor be connected with each other；Root
According to aerobic hemoglobin (HbO2), deoxyhemoglobin (HHb) to the absorption characteristic of near infrared spectrum, by the near infrared spectrum
(NIRS) sensor measurement obtains blood oxygen saturation (SVO2) and hemoglobin concentration (Hb), and the blood oxygen that measurement is obtained is saturated
Spend (SVO2) and hemoglobin concentration (Hb) be transmitted to the microprocessor.
Wherein, the temperature sensor is connected to the microprocessor, and the temperature sensor real-time detection temperature simultaneously will
The temperature data of acquisition is sent to the microprocessor；The microprocessor calculates temperature-compensating according to the temperature data received
Data；
It is influenced by transmitting terminal LED temperature and tested user's human body temperature, under static state the nearside receiving end
Or downward trend can be presented in the received near infrared spectrum in distal side (NIRS) sensor voltage obtained, need according to calculating
The temperature compensation data of acquisition compensates the voltage on the near infrared spectrum (NIRS) sensor, as shown in Figure 2；
Wherein, near infrared spectrum (NIRS) sensor is for measuring local oxygen uptake；The near infrared spectrum
(NIRS) during sensor is used to monitor time maximum and largest motion and the pathology including cardiovascular disease, septicemia is raw
The variation of aerobic hemoglobin saturation degree and blood flow under the conditions of reason.In the near infrared spectrum (NIRS) the working sensor phase
Between, skeletal muscle deoxidation degree changes according to the variation of muscle types, type of sports and blood flow；
Wherein, the microprocessor includes memory, USB interface 6；The temperature sensor, communication module connection
To the microprocessor；Wherein, collected temperature data is transmitted to the microprocessor by the temperature sensor；It is described close
The blood oxygen that the near infrared light spectrum sensor of the near infrared light spectrum sensor and the distal side receiving end that flank receiving end obtains measurement
Saturation degree (SVO2) and hemoglobin concentration (Hb) be transmitted to the microprocessor；The microprocessor can be to the number received
According to calculated, analyzed, storage processing；
Wherein, the USB interface 6 can be used for transmitting data, including upload or downloading data between external equipment；
The memory is for storing data；
Wherein, the communication module is connected to the microprocessor, and the communication module transmits data to external equipment；
In one embodiment, the external equipment includes mobile phone, computer, PDA；Between the communication module and external equipment
It is communicated using bluetooth, WIFI.
Wherein, the power supply closes equipment for the oxygen and provides electric energy.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, can't be such that the essence of corresponding technical solution departs from the spirit and scope of the technical scheme of various embodiments of the present invention.
Claims (5)
1. a kind of muscle oxygen based on NIRS technology closes detection device characterized by comprising
Electrode, light source, nearside receiving end, distal side receiving end, temperature sensor, microprocessor, power supply；
Wherein, the nearside receiving end and the distal side receiving end are different from the distance between the light source；The nearside receives
End and the distal side receiving end all include near infrared light spectrum sensor；The near infrared light spectrum sensor of the nearside receiving end and institute
The near infrared light spectrum sensor for stating distal side receiving end is connected with each other with the microprocessor respectively；It is sensed by the near infrared spectrum
Device measurement obtains blood oxygen saturation and hemoglobin concentration and is transmitted to the microprocessor；
Wherein, the temperature sensor is connected to the microprocessor, and the temperature sensor real-time detection temperature simultaneously will acquire
Temperature data be sent to the microprocessor；The microprocessor calculates temperature-compensating number according to the temperature data received
According to；
The microprocessor calculates the data received, is analyzed, record is handled.
2. the muscle oxygen according to claim 1 based on NIRS technology closes detection device, which is characterized in that
The light source is transmitting terminal LED；The transmitting terminal LED emits close under the driving circuit driving that the microprocessor controls
Infrared light.
3. the muscle oxygen according to claim 1 based on NIRS technology closes detection device, which is characterized in that
The microprocessor includes memory, USB interface；Wherein, the USB interface between external equipment for transmitting number
According to, including upload or downloading data；The memory is for storing the data received.
4. the muscle oxygen according to claim 1 based on NIRS technology closes detection device, which is characterized in that including communicating mould
Block；The communication module is connected to the microprocessor, and the communication module transmits data to external equipment.
5. the muscle oxygen according to claim 1 based on NIRS technology closes detection device, which is characterized in that the outside is set
Standby includes mobile phone, computer, PDA；It is communicated between the communication module and external equipment using bluetooth, WIFI.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811506577.4A CN109692008A (en) | 2018-12-10 | 2018-12-10 | Muscle oxygen based on NIRS technology closes detection device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811506577.4A CN109692008A (en) | 2018-12-10 | 2018-12-10 | Muscle oxygen based on NIRS technology closes detection device |
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| CN109692008A true CN109692008A (en) | 2019-04-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023017682A1 (en) * | 2021-08-10 | 2023-02-16 | 株式会社ジャパンディスプレイ | Device for detecting oxygen saturation of percutaneous muscle |
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| CN107374646A (en) * | 2017-07-31 | 2017-11-24 | 中国科学院半导体研究所 | Blood sugar detection apparatus and method, electronic installation based near infrared technology |
| CN207721812U (en) * | 2017-06-13 | 2018-08-14 | 吉林大学珠海学院 | A kind of Woundless blood sugar concentration detector |
| CN209863834U (en) * | 2018-12-10 | 2019-12-31 | 中国人民解放军总医院 | Muscle oxygenation detection equipment based on NIRS technique |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202526183U (en) * | 2012-04-05 | 2012-11-14 | 王培勇 | Human tissue oxygen content monitor |
| US20170172447A1 (en) * | 2015-12-22 | 2017-06-22 | Imec Vzw | Sensor, System, and Holder Arrangement for Biosignal Activity Measurement |
| CN206526049U (en) * | 2016-08-31 | 2017-09-29 | 北京利络科技有限公司 | A kind of detection device for near-infrared brain scans |
| CN207721812U (en) * | 2017-06-13 | 2018-08-14 | 吉林大学珠海学院 | A kind of Woundless blood sugar concentration detector |
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| WO2023017682A1 (en) * | 2021-08-10 | 2023-02-16 | 株式会社ジャパンディスプレイ | Device for detecting oxygen saturation of percutaneous muscle |
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