CN109673630A - A kind of lipid nano particle and preparation method thereof with controlling plant diseases function - Google Patents
A kind of lipid nano particle and preparation method thereof with controlling plant diseases function Download PDFInfo
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- CN109673630A CN109673630A CN201811565166.2A CN201811565166A CN109673630A CN 109673630 A CN109673630 A CN 109673630A CN 201811565166 A CN201811565166 A CN 201811565166A CN 109673630 A CN109673630 A CN 109673630A
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- parts
- nano particle
- lipid nano
- lipid
- plant diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of lipid nano particle and preparation method thereof with controlling plant diseases function, more particularly to cultural control insect pest field, based on parts by weight, the lipid nano particle includes 1~100 part of substrate lipid, 1~100 part of pharmaceutical active components, 0.1~5 part of surfactant, 100~5000 parts of ethyl alcohol and 1000~50000 parts of water；The pharmaceutical active components are selected from one of difenoconazole, nitrile bacterium azoles, olefin conversion, Triadimenol and Bitertanol or their mixture.The present invention has the advantages that insect pest effect is good and Shaoshi multiple-effect.
Description
Technical field
The present invention relates to cultural control insect pest field, specially a kind of lipid nano particle with controlling plant diseases function
And preparation method thereof.
Background technique
In modern agricultural production, pesticide refers to agriculturally for preventing and treating the chemical agent of pest and disease damage and coordinate plant growth,
Epidemic prevention that it is widely used in agriculture forest and husbandry production, environment and domestic hygiene are removed the evil, industrial goods it is mould proof with it is mothproof etc..Obviously, pesticide
There is irreplaceable role in modern agricultural production.
However, traditional pesticide the defects of there are bad dispersibilities, dust drift, only a small amount of pesticide can reach crop target
Mark position.Therefore, in actual application, not only utilization rate is very low for pesticide, but also the pesticide being lost can be to soil, air
It is polluted with water source, has seriously endangered natural environment.
For this purpose, providing, a kind of formulation rate is few and pharmaceutical preparations that pest control effect is good, is that technical staff is urgently to be resolved
Problem.
Summary of the invention
The present invention provides a kind of lipid nano particle and preparation method thereof with controlling plant diseases function, the lipid are received
The grain of rice has the advantages that Shaoshi multiple-effect.
To achieve the above object, the invention provides the following technical scheme:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, which includes base
1~100 part of material lipid, 1~100 part of pharmaceutical active components, 0.1~5 part of surfactant, 100~5000 parts of ethyl alcohol and water
1000~50000 parts；The pharmaceutical active components are selected from difenoconazole, nitrile bacterium azoles, olefin conversion, Triadimenol and Bitertanol
One of or their mixture.
Preferably, the substrate lipid is selected from glycerin monostearate, oleic acid, tripalmitin and behenyl acid glycerol
One of ester or their mixture.
Preferably, the surfactant selects one of poloxamer, Tween 80 and polyvinylpyrrolidone, or
It is their mixture.
Preferably, the pharmaceutical active components further include in carboxymethyl chitosan, margosine and allicin at least
It is a kind of.Wherein, sustained release can be played the role of by carboxymethyl chitosan being added in the formula of lipid nano particle, to extend drug effect
Action time.Also, margosine and allicin all have expelling parasite, antibacterial effect, will not also pollute to soil.
Preferably, the lipid nano particle further includes stabilizer, the stabilizer is beta-cyclodextrin.Beta-cyclodextrin can embed
Part small molecule cooperates with carboxymethyl chitosan, so that slow release effect more preferably, is more advantageous to extension drug effect.
Preferably, based on parts by weight, the lipid nano particle includes 30~60 parts of glycerin monostearate, oleic acid
40~70 parts, 20~40 parts of difenoconazole, 5~20 parts of Triadimenol, 5~10 parts of Bitertanol, carboxymethyl chitosan 15~
25 parts, 5~15 parts of margosine, 5~10 parts of allicin, 1~3 part of the poloxamer aqueous solution that mass fraction is 0.1%, β-ring paste
10~20 parts of essence, 100~5000 parts of ethyl alcohol and 1000~50000 parts of water.
The present invention also provides a kind of preparation method of lipid nano particle with controlling plant diseases function, the preparation sides
Method includes following preparation step:
S01, according to preset weight number, accurately weigh pharmaceutical active components, be dissolved in ethyl alcohol, obtain medical active group
Divide solution；
S02, according to preset weight number, accurately weigh substrate lipid, after ethanol in proper amount is added, be placed in 40~60 DEG C of temperature
It is dissolved under the conditions of degree, obtains substrate lipid soln；
S03, the above-mentioned pharmaceutical active components solution being prepared and substrate lipid soln are uniformly mixed, obtain mixing molten
Liquid；
In S04, the aqueous surfactant solution for being 40~60 DEG C by the described mixed solution injection temperature, be stirred continuously to
It is uniformly mixed, after cooling, obtains the lipid nano particle.
Preferably, temperature condition is 50 DEG C in step S02.
Preferably, water temperature is 50 DEG C in step S04.
The invention has the benefit that
The present invention is by nanotechnology by that will have inhibition sterol demethylation and can kill various pathogenic microorganisms
Pharmaceutical active components nanosizing embeds or is processed into a nanometer transmission system, and it is homogeneous to become high dispersive, the easy stabilization for being suspended in water
Body.In actually application, the permeability of former pharmaceutical active components is improved, there is the Intelligent environments responses such as targeting, slow controlled release
Characteristic, so that the better effect of crops preventing disease and pest.Also, due to lipid nano particle site of action provided by the invention
And utilization rate is higher, can not only reduce drug in the intracorporal residual of crops, the planting cost of reduction crops, can also solve
Certainly it was administered multipair environment bring pollution problem.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of lipid nano particle in embodiment.
Specific embodiment
Embodiment 1
The present embodiment provides a kind of technical solutions:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, the lipid nano particle include single
30 parts of tristerin, 40 parts of oleic acid, 20 parts of difenoconazole, 50 parts of Triadimenol, 5 parts of Bitertanol, methylol shell are poly-
15 parts of sugar, 5 parts of margosine, 5 parts of allicin, 1 part of the poloxamer aqueous solution that mass fraction is 0.1%, 10 parts of beta-cyclodextrin, second
2000 parts of alcohol and 5000 parts of water.
Above-mentioned lipid nano particle the preparation method is as follows:
S01, according to preset weight number, accurately weigh pharmaceutical active components, be dissolved in the ethyl alcohol measured in advance, obtain
Pharmaceutical active components solution.
S02, according to preset weight number, accurately weigh substrate lipid, after the ethyl alcohol measured in advance is added, be placed in 50 DEG C
It is dissolved under the conditions of temperature, obtains substrate lipid soln.
S03, the above-mentioned pharmaceutical active components solution being prepared and substrate lipid soln are uniformly mixed, obtain mixing molten
Liquid.
In S04, the aqueous surfactant solution for being 50 DEG C by the mixed solution injection temperature, it is stirred continuously to mixing
Uniformly, after cooling, the lipid nano particle is obtained.
Lipid nano particle provided in this embodiment reaches 83.4% to the prevention rate of plant pest, the healing to diseased plant
Rate reaches 72.4%.
Embodiment 2
The present embodiment provides a kind of technical solutions:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, the lipid nano particle include single
40 parts of tristerin, 60 parts of oleic acid, 30 parts of difenoconazole, 10 parts of Triadimenol, 8 parts of Bitertanol, methylol shell are poly-
Sugar 16 parts, 10 parts of margosine, 8 parts of allicin, mass fraction be 0.1% 2 parts of poloxamer aqueous solution, 15 parts of beta-cyclodextrin,
1000 parts of ethyl alcohol and 3000 parts of water.
The preparation method is the same as that of Example 1 for the lipid nano particle.
Lipid nano particle provided in this embodiment reaches 79.7% to the prevention rate of plant pest, the healing to diseased plant
Rate reaches 76.5%.
Embodiment 3
The present embodiment provides a kind of technical solutions:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, the lipid nano particle include single
50 parts of tristerin, 60 parts of oleic acid, 40 parts of difenoconazole, 15 parts of Triadimenol, 10 parts of Bitertanol, methylol shell are poly-
Sugar 20 parts, 13 parts of margosine, 8 parts of allicin, mass fraction be 0.1% 2 parts of poloxamer aqueous solution, 18 parts of beta-cyclodextrin,
4000 parts of ethyl alcohol and 6000 parts of water.
The preparation method is the same as that of Example 1 for the lipid nano particle.
Lipid nano particle provided in this embodiment reaches 84.7% to the prevention rate of plant pest, the healing to diseased plant
Rate reaches 73.6%.
Embodiment 4
The present embodiment provides a kind of technical solutions:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, the lipid nano particle include single
60 parts of tristerin, 40 parts of oleic acid, 30 parts of difenoconazole, 15 parts of Triadimenol, 10 parts of Bitertanol, methylol shell are poly-
10 parts of sugar, 6 parts of margosine, 9 parts of allicin, 3 parts of the poloxamer aqueous solution that mass fraction is 0.1%, 18 parts of beta-cyclodextrin, second
5000 parts of alcohol and 6000 parts of water.
The preparation method is the same as that of Example 1 for the lipid nano particle.
Lipid nano particle provided in this embodiment reaches 75.3% to the prevention rate of plant pest, the healing to diseased plant
Rate reaches 71.2%.
Comparative example 1
The present embodiment provides a kind of technical solutions:
A kind of prescription with controlling plant diseases function, based on parts by weight, the prescription include 30 parts of difenoconazole,
10 parts of Triadimenol, 8 parts of Bitertanol, 16 parts of carboxymethyl chitosan, 10 parts of margosine, 8 parts of allicin, mass fraction are
0.1% 2 parts of poloxamer aqueous solution, 15 parts of beta-cyclodextrin, 1000 parts of ethyl alcohol and 3000 parts of water.
Comparative example 2
The present embodiment provides a kind of technical solutions:
A kind of lipid nano particle with controlling plant diseases function, based on parts by weight, the lipid nano particle include single
40 parts of tristerin, 60 parts of oleic acid, 16 parts of carboxymethyl chitosan, 10 parts of margosine, 8 parts of allicin, mass fraction are
0.1% 2 parts of poloxamer aqueous solution, 15 parts of beta-cyclodextrin, 1000 parts of ethyl alcohol and 3000 parts of water.
Test case 1
In order to verify lipid nano particle provided by the invention to the control efficiency of rice sheath blight disease, technical staff carried out as
Lower experiment:
In Rice Cropping base, selection suffers from 210 plants of banded sclerotial blight diseased plant, is randomly divided into 7 groups, and number is A~G respectively.Its
In, A~D group rice is respectively corresponded using lipid nano particle provided by Examples 1 to 4, is sprayed within every 7 days once, every group of single
Spray pesticide amount is 70ml.E group is corresponding using prescription provided by comparative example 1, and F group is corresponding to use rouge provided by comparative example 2
Matter nanoparticle sprays once for every 7 days, and every group of spray pesticide amount of single is 70ml.G group rice diseased plant as a control group, is sprayed for every 7 days
The pure water of Shi Yici equivalent.After experiment 90 days, each group diseased plant situation such as table 1 is counted.
1 rice diseased plant situation statistical form of table
Test case 2
In order to verify lipid nano particle provided by the invention to the control efficiency of hickory nut root rot, technical staff is carried out
Following experiment:
It chooses in the hickory nut planting base of Linan area, 35 plants of diseased plant for suffering from root rot are randomly divided into 7 groups, number respectively
For A~G.Wherein, A~D group hickory nut diseased plant respectively corresponds using lipid nano particle provided by Examples 1 to 4, sprays within every 7 days
It applies once, each usage amount is 20ml/ plants.E group is corresponding using prescription provided by comparative example 1, and F group is corresponding to use comparative example 2
Provided lipid nano particle sprays once for every 7 days, and each usage amount is 20ml/ plants.G group hickory nut diseased plant as a control group,
Every pure water for spraying an equivalent for 7 days.After experiment 90 days, each group diseased plant situation such as table 2 is counted.
2 Chinese walnut diseased plant situation statistical form of table
Claims (9)
1. a kind of lipid nano particle with controlling plant diseases function, which is characterized in that based on parts by weight, including substrate rouge
1~100 part of matter, 1~100 part of pharmaceutical active components, 0.1~5 part of surfactant, 100~5000 parts of ethyl alcohol and water 1000
~50000 parts；
The pharmaceutical active components are selected from one of difenoconazole, nitrile bacterium azoles, olefin conversion, Triadimenol and Bitertanol,
Or their mixture.
2. a kind of lipid nano particle with controlling plant diseases function according to claim 1, which is characterized in that described
Substrate lipid be selected from one of glycerin monostearate, oleic acid, tripalmitin and Compritol 888 ATO or they
Mixture.
3. a kind of lipid nano particle with controlling plant diseases function according to claim 1, which is characterized in that described
Surfactant selects one of poloxamer, Tween 80 and polyvinylpyrrolidone or their mixture.
4. a kind of lipid nano particle with controlling plant diseases function according to claim 1, which is characterized in that described
Pharmaceutical active components further include at least one of carboxymethyl chitosan, margosine and allicin.
5. a kind of lipid nano particle with controlling plant diseases function according to claim 1, which is characterized in that also wrap
Stabilizer is included, the stabilizer is beta-cyclodextrin.
6. a kind of lipid nano particle with controlling plant diseases function according to claim 1, which is characterized in that with weight
Amount number meter, including 30~60 parts of glycerin monostearate, 40~70 parts of oleic acid, 20~40 parts of difenoconazole, Triadimenol 5~
20 parts, 5~10 parts of Bitertanol, 15~25 parts of carboxymethyl chitosan, 5~15 parts of margosine, 5~10 parts of allicin, quality
1~3 part of poloxamer aqueous solution, 10~20 parts of beta-cyclodextrin, 100~5000 parts of ethyl alcohol and the water 1000 that score is 0.1%
~50000 parts.
7. a kind of preparation method of the lipid nano particle with controlling plant diseases function, which is characterized in that including preparing as follows
Step:
S01, according to preset weight number, accurately weigh pharmaceutical active components, be dissolved in ethyl alcohol, it is molten to obtain pharmaceutical active components
Liquid；
S02, according to preset weight number, accurately weigh substrate lipid, after ethanol in proper amount is added, be placed in 40~60 DEG C of temperature strip
It is dissolved under part, obtains substrate lipid soln；
S03, the above-mentioned pharmaceutical active components solution being prepared and substrate lipid soln are uniformly mixed, obtain mixed solution；
In S04, the aqueous surfactant solution for being 40~60 DEG C by the mixed solution injection temperature, it is stirred continuously to mixing
Uniformly, after cooling, the lipid nano particle is obtained.
8. a kind of preparation method of lipid nano particle with controlling plant diseases function according to claim 1, special
Sign is, in step S02, temperature condition is 50 DEG C.
9. a kind of preparation method of lipid nano particle with controlling plant diseases function according to claim 1, special
Sign is, in step S04, water temperature is 50 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811565166.2A CN109673630A (en) | 2018-12-20 | 2018-12-20 | A kind of lipid nano particle and preparation method thereof with controlling plant diseases function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811565166.2A CN109673630A (en) | 2018-12-20 | 2018-12-20 | A kind of lipid nano particle and preparation method thereof with controlling plant diseases function |
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| CN109673630A true CN109673630A (en) | 2019-04-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112956536A (en) * | 2021-04-13 | 2021-06-15 | 吴善艳 | Formula milk powder containing NMN and preparation method thereof |
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| US20060222716A1 (en) * | 2005-04-01 | 2006-10-05 | Joseph Schwarz | Colloidal solid lipid vehicle for pharmaceutical use |
| CN101755738A (en) * | 2009-11-11 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Solid lipid nano spinosad and preparation method and application thereof |
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2018
- 2018-12-20 CN CN201811565166.2A patent/CN109673630A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060222716A1 (en) * | 2005-04-01 | 2006-10-05 | Joseph Schwarz | Colloidal solid lipid vehicle for pharmaceutical use |
| CN101755738A (en) * | 2009-11-11 | 2010-06-30 | 深圳诺普信农化股份有限公司 | Solid lipid nano spinosad and preparation method and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 刘伟编著: "《生物高分子材料及其应用研究》", 31 March 2018, 成都：电子科技大学出版社 * |
| 王淼编著: "《生物化学》", 31 January 2017, 北京：中国轻工业出版社 * |
| 钟鸣等编著: "《中国壮药学》", 31 May 2016, 南宁：广西民族出版社 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112956536A (en) * | 2021-04-13 | 2021-06-15 | 吴善艳 | Formula milk powder containing NMN and preparation method thereof |
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