CN109646384A - Cortex Eucommiae creams and preparation method thereof - Google Patents

Abstract

A kind of Cortex Eucommiae creams, based on parts by weight, it is made of following component: 10-20 parts of Chinese medicine stoste, 1-3 parts of cetostearyl alcohol, 1-3 parts of cetearyl glucoside, 1.1-2.5 parts of xanthan gum, 3-6 parts of dormant oil, 3-7 parts of ethylhexyl palmitate, 2-5 parts of caprylic/capric triglyceride, 0.3-0.8 parts of vitamin E, 1-3 parts of dimethyl silicone polymer, 50-55 parts of water, 3-7 parts of glycerol, 0.1-0.3 parts of allantoin, 0.01-0.06 parts of Sodium Hyaluronate, 1-3 parts of glycine betaine, 0.2-0.6 parts of emulsifing thickener, 2-5 parts of propylene glycol, 0.06-0.09 parts of decoyl hydroximic acid, to 0.1-0.5 parts of the third ethyl ketone of hydroxyl.The creams can moisturizing, repair skin injury, nti-freckle anti-wrinkle, anti-aging, enhance skin elasticity.

Description

Cortex Eucommiae creams and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of Cortex Eucommiae creams and preparation method thereof.

Background technique

The scientist (D.Hamam) of Britain in 1956 has found that free radical is the arch-criminal for leading to human senility for the first time.This One discovery produces tremendous influence to the development of the mankind.Damage of the free radical to human body is the basic reason of human senility, Reversed to reflect body surface, phenomenon is exactly: first is that dry skin；Second is that skin of face relaxation then generates wrinkle；Third is that hair Hole is coarse；Fourth is that facial colour spot；Fifth is that senile plaque；Sixth is that forming acne, dark sore；Seventh is that skin allergy；Eighth is that skin dimness nothing Gloss blackening etc. brings huge damage to the skin of human body.Skin aging must walk the road of moisturizing, and skin must have the nourishing of water, It is just not in various problems.When skin surface, that is, cuticula moisture content reaches 15-25%, when aqueous sufficient, skin not only can Soft smooth does not have microgroove, can be full of elasticity in feel yet；But with advancing age with undesirable life style, cuticlar water Part is gradually lost, and when content is lower than 10%, skin just will appear drying, microgroove, tight, coarse and furfur etc..Surface layer skin Although moisture content can not be directly obtained from body interior, in the bottom skin corium of skin, but there is moisture content at every moment, continually Flowing supply.So skin moisturizing from source, fundamentally for be exactly the moisture content for supplementing skin corium, skin corium moisturizing is It is the first element of skin makeup.

Skin care item function currently on the market is relatively simple, and natural plant kind cosmetics are current China's cosmetics research and development Development trend, natural plant kind cosmetics, raw material is extensive, ingredient is natural, product safety.Thus it can be clear it is necessary to develop one kind Except free radical, but can moisturizing creams, cater to pursuit of the new period people to beauty.

Summary of the invention

The purpose of the present invention is to provide a kind of Cortex Eucommiae creams and preparation method thereof, obtained creams can moisturizing, repair Multiple skin injury, nti-freckle anti-wrinkle, anti-aging enhance skin elasticity.

Cortex Eucommiae creams of the present invention are made of following component based on parts by weight:

10-20 parts of Chinese medicine stoste, 1-3 parts of cetostearyl alcohol, 1-3 parts of cetearyl glucoside, xanthan gum 1.1-2.5 Part, 3-6 parts of dormant oil, 3-7 parts of ethylhexyl palmitate, 2-5 parts of caprylic/capric triglyceride, 0.3-0.8 parts of vitamin E, poly- two 1-3 parts of methylsiloxane, 50-55 parts of water, 3-7 parts of glycerol, 0.1-0.3 parts of allantoin, 0.01-0.06 parts of Sodium Hyaluronate, sweet tea 1-3 parts of dish alkali, 0.2-0.6 parts of emulsifing thickener, 2-5 parts of propylene glycol, 0.06-0.09 parts of decoyl hydroximic acid, to the third ethyl ketone of hydroxyl 0.1-0.5 parts.

The wherein preferred DC200 model of dimethyl silicone polymer, wherein emulsifing thickener preferably matches Bick 305, and INCI is entitled Polyacrylamide (and) C13-14 isoparaffin (and) laureth -7.

The Chinese medicine stoste is made of following Chinese medicine material based on parts by weight: 5-10 parts of seed of bark of eucommia, folium cortex eucommiae 5-10 Part, 5-10 parts of tea seeds, 3-5 parts of radices trichosanthis, 2-5 parts of cortex cinnamomi, 2-6 parts of Chinese yam, 3-5 parts of pueraria lobata, 3-6 parts of the bletilla striata, radix polygonati officinalis 3-7 Part, Radix Ophiopogonis 3-6 part, 2-5 parts of fennel, 2-5 parts of Rhizoma Atractylodis Macrocephalae, 2-5 parts of gypsum, 3-5 parts of radix achyranthis bidentatae, 3-5 parts of honeysuckle, 2-5 parts octagonal, mulberry 3-5 parts of silkworm, 3-5 parts of frutus cnidii, 3-5 parts of ginkgo leaf, 2-5 parts of cortex dictamni, 3-6 parts of peach blossom, 3-7 parts of peach kernel, 3-5 parts of Chinese gall, 2-5 parts of stalactite, 2-5 parts of borneol camphor tree, 3-7 parts of the fruit of summer cypress, 3-7 parts of , china dodder of Chinese aloe leaf 3-8 Fen, 3-5 parts of radix ampelopsis, rhizoma polygonati 2-6 Part, 3-7 parts of Rhizoma Chuanxiong, 2-6 parts of ageratum, 2-7 parts of the fruit of a cubeb litsea tree.

The Chinese medicine stoste the preparation method is as follows:

(1) by Chinese medicine material co-grinding 30-60 mesh, extractor (spreading active carbon in extractor bottom) is poured into, first is used Alcohol carries out reflux extraction decoloration, and temperature is controlled at 45-55 DEG C；

(2) Chinese medicine stoste extracted is subjected to decoloration separation, separates methanol, concentration, then plus 35-45wt%'s Propylene glycol (referring to that propylene glycol accounts for the 35-45wt% of total amount) carries out preservation and antisepsis to Chinese medicine stoste, does not add preservative, obtains Chinese medicine Stoste.

Wherein in step (1) methanol with Chinese medicine material weight ratio be (0.5-3): 1.

The preparation method of Cortex Eucommiae creams of the present invention, in turn includes the following steps:

(a) by 1-3 parts of cetostearyl alcohol, 1-3 parts of cetearyl glucoside, 1-2 parts of xanthan gum, ethylhexyl palmitate 3-7 parts, 2-5 parts of caprylic/capric triglyceride, 0.3-0.8 parts of vitamin E, 3-6 parts of dormant oil, 1-3 parts of dimethyl silicone polymer altogether It is mixed even as A phase；

(b) by 50-55 parts of water, 0.1-0.5 parts of xanthan gum, 3-7 parts of glycerol, 0.1-0.3 parts of allantoin, Sodium Hyaluronate 0.01-0.06 parts, 1-3 parts of glycine betaine are blended uniformly as B phase；

(c) it respectively by A phase, B heat phase to 75-85 DEG C, is dispersed with stirring uniformly；

(d) A is then added to B phase, emulsifying 10-15 minutes, insulated and stirred was cooled to 55- after 20-25 minutes 60 DEG C of addition emulsifing thickeners, stir evenly；

(e) it is separately added into 2-5 parts of propylene glycol after being cooled to 40-50 DEG C, 0.06-0.09 parts of decoyl hydroximic acid, to hydroxyl third It 0.1-0.5 parts and Chinese medicine stoste 10-20 parts of ethyl ketone, stirs evenly.

Inventive formulation uses antioxidation method nti-freckle, and superfluous free radical is in vivo with the breeding side of chain reaction Formula constantly aoxidizes, corrodes normal cell, causes cell metabolism obstructed, and TYR enzyme activity is caused to increase significantly, and pigment closes Accelerate at speed, pigment granule is difficult to normally decompose excretion, constantly deposits, gradually forms unpleasant color in skin surface Spot.The antioxidant content of inventive formulation enters in vivo, supplements a large amount of antioxidants, and establishes anti-oxidant composite barrier together, Stop free radical constantly to corrode, makes normal cell metabolism functional rehabilitation unimpeded, put on antioxidant defense film to cell, play antioxygen Change the effect of nti-freckle.

Creams of the present invention have the beneficial effect that:

1, it is emulsified and is formed by Cortex Eucommiae Chinese medicine stoste and crude vegetal, skin is not stimulated；

2, creams, which are wiped, feels on the face without oil, salubrious fine and smooth；

3, can moisturizing, repair skin injury, nti-freckle anti-wrinkle, anti-aging, enhance skin elasticity.

Chinese medicine material used in the present invention is as follows:

(1) seed of bark of eucommia: alias silk cotton tree, the silk flosssilk wadding skin, Yu Sipi of Cortex Eucommiae.Cortex Eucommiae is in the upper solely tree one of botany classification Flag, only a section, one belong to, are a kind of；The seed-producing rate of seed of bark of eucommia about 28%, seed of bark of eucommia oil content is generally in 27%-33%, seed of bark of eucommia Polyunsaturated fatty acid is rich in oil.

(2) folium cortex eucommiae: folium cortex eucommiae is a kind of Eucommiaceae plant, and alias silk cotton tree, silk flosssilk wadding skin, Yu Sipi have with Bark of Eucommia Ulmoides Identical effective component and pharmacological action.

(3) tea seeds: tea seeds be plant of theaceae tea tree (i.e. people it is daily in the tealeaves drunk, non-tea oil tree) fruit It is real, the compressible edible oil as tea seed, the tea polyphenols in tea seed oil, tocopherol (VE) content much higher than other oil, because This is referred to as " oil yellow gold ".

(4) radices trichosanthis: radices trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, is clearing heat-fire class drug, tool Body effect is clearing heat-fire, is promoted the production of body fluid to quench thirst, apocenosis detumescence.The major functions: controlling, pyreticosis is thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle swells, hemorrhoid Impotence.For treating diabetes, commonly uses it and be used cooperatively with drugs for nourishing yin, to have the function that treating both manifestation and root cause of disease.

(5) cortex cinnamomi: Classification system Cinnamomum cassia Presl is Lauraceae, the medium megaphanerophyte of Cinnamomum, bark ash Brown.

(6) Chinese yam: also known as Chinese yam, native potato, sweet potato Chinese yam, RHIIZOMA DIOSCOREAE from Henan of China, Chinese yam, white Chinese yam are the grass that " China's book on Chinese herbal medicine " records Medicine, medicinal source are Dioscoreaceae plant Chinese yam dry rhizome.Chinese yam has nourishing strong, aid digestion, holds back abnormal sweating, the function of antidiarrheal Effect cures mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequency, spermatorrhea, women's leukorrhagia and dyspeptic chronic intestines It is scorching.

(7) it pueraria lobata: for the dry root of legume pueraria lobata, practises and claims elegant jessamine.Autumn, the excavation of two season of winter, take advantage of fresh-cut at sheet or Fritter；It is dry.It is sweet, pungent, it is cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the function of Shengyang Zhixie.It is usually used in exterior syndrome fever, person's back Strong pain, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.

(8) bletilla striata: also known as Lian Jicao, Gan Gen, give free of charge, indocalamus is blue, Zhu Lan (" presbyopic glasses "), purple blue, purple a species of orchid, hundred large bamboo hats with a conical crown and broad brim.Main carbuncle swells, Malignant sore loses subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach.

(9) radix polygonati officinalis: scientific name Polygonatum odoratum (Mill.) Druce is Liliaceae herbaceos perennial. The yin-nourishing of radix polygonati officinalis tool is moisturized, heat-clearing, is promoted the production of body fluid, cough-relieving and other effects.As tonic, consumption of YIN caused by febrile disease, abnormal heat cough caused by dryness, heart are cured mainly The diseases such as disease, diabetes, tuberculosis.

(10) Radix Ophiopogonis: scientific name Ophiopogon japonicus (Linn.f.) Ker-Gawl., Liliaceae Ophiopogon are more The small root tuber of Nian Sheng evergreen herbage, Radix Ophiopogonis is Chinese medicine, there is the benefits of quench one's thirst of promoting the production of body fluid, moistening lung to arrest cough.

(11) fennel: the small bosom of original name is fragrant again for fennel dish, also known as perfume silk dish, fennel seeds, aniseed, Gu Xiang (Sichuan, Guizhou), Muddy perfume (or spice), the stem of fennel seeds and tender leaf can make vegetables, and seasoning fennel seeds are the dry mature fruit of foeniculum vulgare.Fennel temperature Kidney cold dispelling, relieving the gastric disorder and regulating vital energy.Cold hernia, abdomen crymodynia are controlled, lumbago due to the kidney deficiency is had a stomachache, and vomiting is done, weak foot due to dampness.

(12) Rhizoma Atractylodis Macrocephalae: alias small wooden raft Ji, Yu Shu, winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, piece art, rhizoma atractylodis etc. belong to composite family, grey Art category herbaceos perennial.Nice and cool weather is liked, is used as medicine with rhizome, there is multinomial medicinal function.Rhizoma Atractylodis Macrocephalae has strengthening the spleen and replenishing qi, dry The effect of wet Li Shui, hidroschesis, miscarriage prevention, is used for spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, threatened abortion." doctor Learn Qi Yuan " it records: " the dry and middle QI invigorating of dehumidifying benefit, middle benefit gas, go wet in taste, remove stomach energy, strong taste, into diet, miscarriage prevention."

(13) gypsum: gypsum is monoclinic system mineral, is the hydrate that main chemical compositions are calcium sulfate (CaSO4).

(14) radix achyranthis bidentatae: alias ox knocks knee, Latin literary fame: Achyranthes bidentata Blume. Amaranthaceae, Achyranthes Perennial herb, root are used as medicine, raw to use, blood circulation；Control postpartum abdominal pain, irregular menstruation, amenorrhoea, nosebleed epistaxis, toothache caused by fire of deficiency type, beriberi liquor It is swollen；Ripe use, nourishing liver and kidney, strong waist and knee；Control soreness of waist and knee joint, caused by liver and kidney deficiency, bruise stasis caused pain.Animal doctor, which is used as, controls soft cattle, gets injured by a fall disconnected Bone etc..

(15) honeysuckle: just entitled honeysuckle, honeysuckle flower are known as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, it is sweet Heat-clearing tremble with fear without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various hot Disease, such as body heat, dermexanthesis, macular eruption, heat toxin sore carbuncle, abscess of throat disease, equal significant effect.

(16) octagonal: octagonal fruit is famous flavoring, also hyoscine.Pericarp, seed, Ye Douhan aromatic oil are systems The important source material of good fortune cosmetic, julapium, beer and food industry.

(17) silkworm: be it is a kind of secrete an insect using mulberry leaf as the Lepidoptera of foodstuff, belong to invertebrate, Arthropoda silkworm Moth section silkworm moth category Silkworm.

(18) frutus cnidii: alias cicely, is the dry mature fruit of umbelliferae cnidium monnieri.Summer, Qiu Erji fruit It is harvested when real mature, removes impurity, dry.Major function: eliminating dampness, wind-dispelling, desinsection, warming kidney and enhancing body.For impotence, palace cold, tremble with fear Under wet bands, arthritis with fixed pain caused by dampness pain in the loins；Eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis are controlled outside.

(19) ginkgo leaf: for the dried leaf of Ginkgoaceae plant Ginkgo biloba Ginkgo biloba L..The still green Shi Caishou of autumn leaf, It is dry in time.Generally artificial cultivation.It with activating microcirculation and removing stasis medicinal, removes obstruction in channels to relieve pain, astringing lung-QI is relievingd asthma, the effect of changing turbid lipid-loweringing.For the stasis of blood Blood hinders network, chest impediment and cardialgia, hemiplegia, deficiency syndrome of the lung cough and asthma, hyperlipidemia.

(20) cortex dictamni: alias dittany bark, stereotyped writing ox, seguin argyreia herb, sheep fresh grass, Latin literary fame: in CORTEX DICTAMNI Medicine name.For the root skin of Rutaceae herbaceos perennial shaggy-fruited dittany and Dictamnus angustifolius.Main product is in Liaoning, Hebei, Sichuan, Jiangsu etc. Ground.Spring, two season of autumn excavate root, remove silt and rough bark, strip root skin, are sliced, dry.With heat-clearing and damp-drying drug, wind-dispelling removing toxic substances The effect of.

(21) peach blossom: i.e. peach blooming flower piece belongs to rosaceous plant.

(22) peach kernel: for rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) dry mature seed of Franch..It is harvested after fruit maturation, removes pulp and nucleocapsid, taken out seed, dry.Have Promoting blood circulation, relax bowel and defecation, relieving cough and asthma effect.For amenorrhea and algomenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, pulmonary abscess acute appendicitis, injury from falling down, intestinal dryness Constipation, cough and asthma.

(23) Chinese gall: also known as hundred worm storehouses, fermented Chinese gall herb and tea leaves, gall, it is the horned gall aphid or melaphis peitan Tsai et Tang female adult of Homoptera aphid section It parasitizes Anacardiaceae plant " Chinese sumac " and its belongs to the tender leaf or petiole of other plant, stab and generate a kind of cryptomere consor object Insect gall, gained after baked drying.In addition, Chinese gall or a kind of medicinal material, can treat a variety of diseases.

(24) stalactite: stalactite (stalactite), also known as stalactite refer in the cave of carbonate rock area very long The general name of the different shapes lime deposits such as stalactite, stalagmite, the stone column formed in earth history and under the conditions of specific geology.

(25) borneol camphor tree: being by the resin of the pure white such as ice of the one kind being precipitated in the branches and leaves of borneol camphor tree, because it is shaped like plum The crystalline solid of petal, therefore many titles such as have natural borneol, Borneolum again.

(26) fruit of summer cypress: for the dry mature fruit of chenopod fruit of summer cypress Kochia scoparia (L.) Schrad.. Plant is harvested when the fruit matures in the fall, is dried, fruit is laid, and removes impurity.For difficulty and pain in micturition, pruritus vulvae leukorrhagia, rubeola is wet Rash, pruitus.

(27) Chinese aloe leaf: for liliaceous plant stripe aloe vera Aloe vera L.var.chinensis (Haw.) Berger. Or the leaf of aloe barbadensis Miller Aloe vera L. etc..With purging intense heat, the effect of removing toxic substances, stagnation resolvation, desinsection.It is usually used in hot eyes, constipation, Gonorrhoea, hematuria, pediatric epilepsy scared, infantile malnutrition due to digestive disturbances or intestinalparasites, burn and scald, women's menostasis, hemorrhoid, scabies, carbuncle and furuncle and pyogenic infections, traumatic injury.

(28) china dodder: also known as Huang Siteng is Convolvulaceae (Convolvulaceae) parasitic plant, major function: nourishing liver Kidney, astringent sperm contracting urine, miscarriage prevention, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, Vaginal bleeding due to deficiency of the kidney during pregnancy, threatened abortion, spleen kidney deficiency are rushed down；Externally treating leucoderma.

(29) radix ampelopsis: also known as mountainous region melon, wild sweet potato, V. amurensis seedling, Bai Gen, five pawl rattans etc., it is vitaceae radix ampelopsis Dried root.Spring, the excavation of two season of autumn, silt and radicula are removed, vertical valve or inclined tab is cut into, dries.Can be clearing heat and detoxicating, the carbuncle that disappears dissipates Knot.

(30) rhizoma polygonati: for liliaceous plant polygonatum kingianurn Polygonatum kingianum Coll.et Hemsl., rhizoma polygonati The dry rhizome of Polygonatum sibiricum Red. or polygonatum cyrtonema Polygonatum cyrtonema Hua.With benefit The effect of gas yin-nourishing, invigorating the spleen, moistening lung, kidney-nourishing.It is usually used in deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, the deficiency syndrome of the lung is dry Cough, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.

(31) Rhizoma Chuanxiong: scientific name Ligusticum chuanxiong hort, cultivated plant are a kind of Chinese medicinal plants, are commonly used In blood-activating and qi-promoting, wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walks without keeping, can go it is scattered, uplink up to mountain peak push up；Enter blood system, downlink again Up to the sea of blood.Promoting blood circulation effect is suitable for the various illnesss of stagnation of blood stasis extensively；Wind-expelling pain-stopping, effectiveness is favourable, can control intermittent headache head Bitterly, the diseases such as rheumatic arthralgia.It is the gas medicine in blood that former times people, which calls Rhizoma Chuanxiong, nearly says its function such as pungent scattered, relieve stagnation, sensible, analgesic of residing.

(32) ageratum: for Labiatae herbaceous plant Pogostemon cablin Pogostemincablin (Blanco) Benth. or wrinkled giant hyssop The ground part of Agastacherugosus (Fisch.etMey) O.Ktze., at the beginning of dampness taste, abdominal fullness and distention, damp-warm syndrome It rises, vomiting, diarrhea, summer-heat and damp, fever with chilliness, fever with aversion to cold, the diseases such as chest distress.

(33) fruit of a cubeb litsea tree: also known as cubeb litsen tree, Tetranthera citrata, Alpinia japonica, Litsea chenii, Litsea pungens, it is Lauraceae, Litsea fallen leaves Shrub or dungarunga, treelet bark yellow green is smooth, veteran bark taupe.Nature and flavor are pungent, slight bitter, aromatic, nontoxic.Every year November to second year April blooms, and branch, leaf all have fragranced.Root skin and leaf can hyoscines.With warm kidney stomach invigorating, promoting the circulation of qi dissipating bind The effect of.For treating the diseases such as gastralgic vomitting and nameless sores or boils.

Specific embodiment

In order to illustrate more clearly of the present invention, enumerate following embodiment and comparative example, but its to the range of invention without any Limitation.

Raw material used in embodiment 1-5, comparative example 1-3 Chinese medicine stoste and quality are as shown in table 1, and unit is kilogram.

Table 1

	Embodiment 1	Embodiment 2	Embodiment 3	Embodiment 4	Embodiment 5	Comparative example 1	Comparative example 2	Comparative example 3
									Seed of bark of eucommia	5	6	7	8	9	-	9	9
Folium cortex eucommiae	5	8	7	6	6	6	6	6
									Tea seeds	5	6	7	8	9	9	9	9
Radices trichosanthis	3	4	5	4	3	3	3	3
									Cortex cinnamomi	3	5	4	3	2	2	2	2
Chinese yam	3	4	5	6	4	4	4	4
									Pueraria lobata	3	6	5	4	5	5	5	5
The bletilla striata	3	4	5	6	4	4	4	4
									Radix polygonati officinalis	4	5	5	7	5	5	5	5
Radix Ophiopogonis	3	4	5	6	4	4	4	4
									Fennel	3	5	4	2	3	3	3	3
Rhizoma Atractylodis Macrocephalae	3	5	4	2	3	3	3	3
									Gypsum	3	2	4	5	4	4	4	4
Radix achyranthis bidentatae	3	4	5	4	5	5	5	5
									Honeysuckle	3	4	5	4	5	5	5	5
It is octagonal	3	5	4	4	3	3	3	3
									Silkworm	3	4	5	4	5	5	5	5
Frutus cnidii	3	5	5	4	4	4	4	4
									Ginkgo leaf	3	4	4	5	5	5	5	5
Cortex dictamni	3	4	5	2	3	3	3	3
									Peach blossom	3	4	5	4	4	4	4	4
Peach kernel	3	6	7	5	4	4	4	4
									Chinese gall	3	4	5	4	5	5	5	5
Stalactite	3	2	3	5	4	4	-	4
									Borneol camphor tree	3	3	5	4	4	4	4	-
The fruit of summer cypress	3	4	5	6	7	7	7	7
									Chinese aloe leaf	3	8	7	5	4	4	4	4
China dodder	3	4	5	6	7	7	7	7
									Radix ampelopsis	3	5	5	4	3	3	3	3
Rhizoma polygonati	3	2	4	5	5	5	5	5
									Rhizoma Chuanxiong	3	4	5	6	7	7	7	7
Ageratum	3	6	5	4	3	3	3	3
									The fruit of a cubeb litsea tree	3	4	5	6	7	7	7	7

Comparative example 1 eliminates seed of bark of eucommia on the basis of embodiment 5, and comparative example 2 eliminates clock on the basis of embodiment 5 Mammary calculus, comparative example 3 eliminates borneol camphor tree on the basis of embodiment 5, other same as Example 5.

Above embodiments, comparative example Chinese medicine stoste the preparation method is as follows:

(1) by Chinese medicine material co-grinding 30-60 mesh, extractor (spreading active carbon in extractor bottom) is poured into, first is used Alcohol carries out reflux extraction decoloration, and temperature is controlled at 50-55 DEG C；

(2) Chinese medicine stoste extracted is subjected to decoloration separation, separates methanol, then concentration adds the third of 40wt% Glycol carries out preservation and antisepsis to Chinese medicine stoste, does not add preservative；Obtain Chinese medicine stoste.

Wherein in step (1) methanol with Chinese medicine material weight ratio be 2:1.

Above embodiments, comparative example Cortex Eucommiae creams the preparation method is as follows:

(a) by 2.50 kilograms of cetostearyl alcohol, 2.50 kilograms of cetearyl glucoside, 1.50 kilograms of xanthan gum, palm 4 kilograms of sour ethylhexyl, 3 kilograms of caprylic/capric triglyceride, 0.5 kilogram of vitamin E, 5 kilograms of dormant oil, polydimethylsiloxanes 2 kilograms of alkane are blended uniformly as A phase；

(b) by 52.47 kilograms of water, 0.40 kilogram of xanthan gum, 5 kilograms of glycerol, 0.2 kilogram of allantoin, Sodium Hyaluronate 0.05 kilogram, 2 kilograms of glycine betaine are blended uniformly as B phase；

(c) it respectively by A phase, B heat phase to 80 DEG C, is dispersed with stirring uniformly；

(d) A is then added to B phase, emulsifying 10 minutes, insulated and stirred was cooled to 60 DEG C of addition creams after twenty minutes Change thickener, stirs evenly；

(e) it is separately added into 3 kilograms of propylene glycol after being cooled to 45 DEG C, 0.08 kilogram of decoyl hydroximic acid, to the third ethyl ketone of hydroxyl 0.3 Kilogram and 15 kilograms of Chinese medicine stoste, stir evenly.

The embodiment of the present invention, comparative example effect test:

(1) measuring method of radicals scavenging effect is as follows:

It is respectively the concentration of mass volume ratio 1% at concentration by embodiment, the sample preparation of comparative example with dimethyl sulfoxide, Carry out following experiment:

Take sample solution 2ml and concentration for the two phenyl picryl benzene hydrazine ﹙ DPPH ﹚ solution (solvents of the solution of 100umol/L It is for water) 2ml is first added in same tool plug test tube, shakes up, 30 minutes are stood at room temperature, using solvent as blank, in 517nm wavelength Lower measurement sample absorbance.

Inhibiting rate: k%=[1- (Ai-Aj)/AC] × 100%

The absorbance of Ai:2mlDPPH solution+2ml sample solution

The absorbance of Aj:2ml sample solution+2ml solvent (i.e. dimethyl sulfoxide)

The absorbance of AC:2mlDPPH solution+2ml solvent (i.e. dimethyl sulfoxide)

Experimental result is shown in Table 2:

Table 2

The experimental results showed that creams of the invention can effectively inhibit the generation of free radical, and significant effect.

(2) measurement of freckle effect:

(1) patient:

Selection screening 160 has the healthy population of freckle and spot on the face, and men and women is unlimited, is randomly divided into 8 groups, every group 20 People, respectively using the creams of embodiment 1-5, comparative example 1-3.

(2) application method:

It is air-dried after being cleaned skin with warm water；2 drop of drop is put on after repeatedly soft and loops on the face in the palm of the hand, then the palm of the hand is light again It pats and beats face to fully absorbing；Adhere to once in the morning and once at night daily, experimental period is 30 days.

Evaluation criterion: effectively: spot, freckle obviously decline；Effective: spot and freckle have decline；It is invalid: unchanged.Tool Body the results are shown in Table 3.

Table 3

	Effectively	It is effective	In vain
				Embodiment 1	17	2	1
Embodiment 2	18	2	0
				Embodiment 3	16	3	1
Embodiment 4	17	3	0
				Embodiment 5	17	3	0
Comparative example 1	12	3	3
				Comparative example 2	12	4	2
Comparative example 3	13	4	3

As shown in Table 3, the freckle effect of embodiment 1-5 is all fine.

(3) measurement of moistening effect:

Drying is to lead to a major reason of the long spot of skin, and experimental results demonstrate the moisture in holding skin can be significantly Alleviate melanin deposition problem.Therefore desalination blackspot, the moisture lockked in skin just become an important approach.

A establishes experimental model:

It allows moisture to evaporate in its natural state with the skin of pigskin simulation people, periodically claims its quality, count according to the following formula Moisturizing rate is calculated, its moistening effect is evaluated.

Moisturizing rate R=(Hn/Ho) × 100%, Hn is the quality of sample after n hour, matter Ho initial for sample in formula Amount.

B experimental procedure

Totally 8 samples take a smooth pigskin, go as experimental group for Example 1-5, the resulting creams of comparative example 1-3 Fall extra grease and clean up, pigskin is cut into the test sample of 3cm × 3cm, 10min is impregnated in distilled water, allows pig Skin fully absorbs moisture, stands spare for 24 hours after taking-up, takes creams 20ml respectively, is placed in the small beaker of 50ml, by what is prepared Pigskin is put into respectively in the beaker of different creams, is taken out pigskin after impregnating 30min, is wiped the creams on surface, weigh quality respectively After be placed on 20 DEG C of temperature, allow moisture natural evaporation in the environment of relative humidity 75%；Claim 1 inferior quality every a few houres, records number According to and calculate the moisturizing rate of each item for disposal.

C result statistics and analysis

Table 4 lists the simulation performance of keeping humidity situation of embodiment 1-5, comparative example 1-3 creams, and moisturizing rate unit is %.

Table 4

Processing	2h	6h	10h	12h	16h	20h	24h
								Embodiment 1	96.5	85.6	79.9	75.8	70.9	67.2	64.5
Embodiment 2	97.5	87.8	80.0	76.0	71.5	68.0	65.1
								Embodiment 3	96.9	86.5	79.8	75.6	70.7	66.8	64.0
Embodiment 4	96.4	85.3	79.5	74.9	70.6	66.7	63.1
								Embodiment 5	97.0	86.4	79.9	76.1	71.4	68.2	66.5
Comparative example 1	88.9	80.7	74.9	70.4	66.7	63.5	60.2
								Comparative example 2	93.0	82.8	76.1	74.2	69.5	66.4	62.1
Comparative example 3	92.0	81.4	75.5	71.8	67.3	64.2	62.0

The results showed that creams of the present invention have excellent performance of keeping humidity, for moisturizing and nourishing skin, prevent pigment heavy Product keeps skin moisture to have important effect.

It can be seen that in creams formula system of the present invention from table 2-4, seed of bark of eucommia, clock stone cream and borneol camphor tree are for moisturizing There is synergistic effect with freckle effect.

The above content describes basic principles and main features of the invention, and the present invention is not limited to the above embodiments, Without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements are all It falls into scope of the claimed invention.

Claims (7)

1. a kind of Cortex Eucommiae creams, based on parts by weight, it is characterised in that be made of following component:

10-20 parts of Chinese medicine stoste, 1-3 parts of cetostearyl alcohol, 1-3 parts of cetearyl glucoside, 1.1-2.5 parts of xanthan gum, mine It is 3-6 parts oily, 3-7 parts of ethylhexyl palmitate, 2-5 parts of caprylic/capric triglyceride, 0.3-0.8 parts of vitamin E, poly dimethyl 1-3 parts of siloxanes, 50-55 parts of water, 3-7 parts of glycerol, 0.1-0.3 parts of allantoin, 0.01-0.06 parts of Sodium Hyaluronate, glycine betaine 1-3 parts, 0.2-0.6 parts of emulsifing thickener, 2-5 parts of propylene glycol, 0.06-0.09 parts of decoyl hydroximic acid, to the third ethyl ketone of hydroxyl 0.1- 0.5 part.

2. Cortex Eucommiae creams according to claim 1, it is characterised in that the Chinese medicine stoste, based on parts by weight, by as follows Chinese medicine material is made: 5-10 parts of seed of bark of eucommia, 5-10 parts of folium cortex eucommiae, and 5-10 parts of tea seeds, 3-5 parts of radices trichosanthis, 2-5 parts of cortex cinnamomi, mountain 2-6 parts of medicine, 3-5 parts of pueraria lobata, 3-6 parts of the bletilla striata, 3-7 parts of radix polygonati officinalis, Radix Ophiopogonis 3-6 part, 2-5 parts of fennel, 2-5 parts of Rhizoma Atractylodis Macrocephalae, gypsum 2-5 Part, it is 3-5 parts of radix achyranthis bidentatae, 3-5 parts of honeysuckle, 2-5 parts octagonal, 3-5 parts of silkworm, 3-5 parts of frutus cnidii, 3-5 parts of ginkgo leaf, cortex dictamni 2- 5 parts, 3-6 parts of peach blossom, 3-7 parts of peach kernel, 3-5 parts of Chinese gall, 2-5 parts of stalactite, 2-5 parts of borneol camphor tree, 3-7 parts of the fruit of summer cypress, aloe 3-7 parts of , china dodder, 3-5 parts of radix ampelopsis, 2-6 parts of rhizoma polygonati, 3-7 parts of Rhizoma Chuanxiong, 2-6 parts of ageratum, 2-7 parts of the fruit of a cubeb litsea tree of leaf 3-8 Fen.

3. Cortex Eucommiae creams according to claim 2, it is characterised in that the Chinese medicine stoste the preparation method is as follows:

(1) by Chinese medicine material co-grinding 30-60 mesh, extractor is poured into, carries out reflux extraction decoloration with methanol, temperature control exists 45-55℃；

(2) Chinese medicine stoste extracted is subjected to decoloration separation, separates methanol, concentration, then plus the third the two of 35-45wt% Alcohol carries out preservation and antisepsis to Chinese medicine stoste, does not add preservative, obtains Chinese medicine stoste.

4. Cortex Eucommiae creams according to claim 3, feature weight ratio of the methanol with Chinese medicine material in step (1) wherein For (0.5-3): 1.

5. Cortex Eucommiae creams according to claim 1, it is characterised in that the dimethyl silicone polymer is DC200 type.

6. Cortex Eucommiae creams according to claim 1, it is characterised in that the emulsifing thickener is match Bick 305.

7. the preparation method of Cortex Eucommiae creams according to claim 1, which is characterized in that in turn include the following steps:

(a) by 1-3 parts of cetostearyl alcohol, 1-3 parts of cetearyl glucoside, 1-2 parts of xanthan gum, ethylhexyl palmitate 3-7 Part, 2-5 parts of caprylic/capric triglyceride, 0.3-0.8 parts of vitamin E, 3-6 parts of dormant oil, 1-3 parts of dimethyl silicone polymer blendings Uniformly it is used as A phase；

(b) by 50-55 parts of water, 0.1-0.5 parts of xanthan gum, 3-7 parts of glycerol, 0.1-0.3 parts of allantoin, Sodium Hyaluronate 0.01- 0.06 part, 1-3 parts of glycine betaine are blended uniformly as B phase；

(c) it respectively by A phase, B heat phase to 75-85 DEG C, is dispersed with stirring uniformly；

(d) A is then added to B phase, emulsifying 10-15 minutes, insulated and stirred was cooled to 55-60 DEG C after 20-25 minutes Emulsifing thickener is added, stirs evenly；

(e) it is separately added into 2-5 parts of propylene glycol after being cooled to 40-50 DEG C, 0.06-0.09 parts of decoyl hydroximic acid, to the third ethyl ketone of hydroxyl It 0.1-0.5 parts and Chinese medicine stoste 10-20 parts, stirs evenly.