CN109620997A - Liquefaction of fat wound healing functional dressings and preparation method thereof - Google Patents

Liquefaction of fat wound healing functional dressings and preparation method thereof Download PDF

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Publication number
CN109620997A
CN109620997A CN201910048482.0A CN201910048482A CN109620997A CN 109620997 A CN109620997 A CN 109620997A CN 201910048482 A CN201910048482 A CN 201910048482A CN 109620997 A CN109620997 A CN 109620997A
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layer
liquefaction
wound healing
polyvinyl alcohol
fat
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CN201910048482.0A
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Chinese (zh)
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万绵水
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/425Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/62Compostable, hydrosoluble or hydrodegradable materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a kind of liquefaction of fat wound healing functional dressings and preparation method thereof.Preparation method is the following steps are included: S1: using polyvinyl alcohol biomaterial for medical purpose as raw material, production obtains sponge dressing;S2: the sponge dressing is compressed, for making it form tiny structure in imbibition;S3: uniformly punching on the compressed sponge dressing, finally obtains the liquefaction of fat wound healing functional dressings.Functional dressings of the present invention use polyvinyl alcohol biomaterial for medical purpose for raw material, be a kind of absorbent it is excellent, with human contact when surface it is extremely soft can natural degradation completely high molecular material.In addition, functional dressings of the present invention are easy to use, once use, can quick drainage, liquid absorption amount is big, can promote wound healing, reduces the risk of secondary pollution;And it is long-term without replacement, reduce dressing change frequency, while reducing the pain of patient, reduces the workload of medical staff.

Description

Liquefaction of fat wound healing functional dressings and preparation method thereof
Technical field
The present invention relates to medical biomaterial technical fields, more particularly to a kind of liquefaction of fat wound healing functional dressings And preparation method thereof.
Background technique
The liquefaction of fat of surgical incision refers to the significant quantities of fat cell rupture of notch, and intracellular lipochondrion is excessive, It decomposes, forms liquid grease, accumulate in notch;It is common in the thicker and fat patient of fat.Liquefaction of fat, which seriously affects, cuts Mouth healing increases infection risk, serious to will cause septicemia, septicopyemia threat to life.
In view of the above-mentioned problems, there are many defects for traditional treatment method.Specifically, conventional method is to strut notch or dismounting A part of suture, or even whole notch are opened wide when necessary, using liquoring fat is squeezed out, hypertonic saline is rinsed, saline gauze drainage The methods of, then with bandage pressure dressing;The next day of needing or daily dressing are primary.However, saline gauze drainage effect itself is very It is limited, and the fat drop for the floating that dissociates in wound cannot be adsorbed, wound long period of soaking is in diffusate, and granulation oedema is micro- to follow Ring is bad, influences wound healing, and is easy to be infected.Simultaneously as long-term and frequent dressing, patient is difficult to endure dressing Bring pain, and also increase the workload of medical staff.
Based on this, providing the novel functional dressings that can effectively facilitate liquefaction of fat wound healing of one kind has important meaning Justice.
Summary of the invention
For this purpose, the present invention is intended to provide a kind of liquefaction of fat wound healing functional dressings and preparation method thereof.Function of the present invention Energy dressing uses polyvinyl alcohol biomaterial for medical purpose, is that a kind of absorbent is excellent, extremely soft with surface when human contact Can completely natural degradation high molecular material;Its is easy to use, can promote wound healing, especially promotes operation fat liquor Change wound drainage healing.Specifically, liquefaction of fat wound healing functional dressings of the present invention can be used for the operation of various liquefaction of fat and cut Mouthful, drainage treatment is carried out by incisional wounds of the microkinetic negative pressure technique to liquefaction of fat, is finally reached quick healing of wound Effect.
To achieve the above object, the present invention the following technical schemes are provided:
In a first aspect, the present invention provides a kind of preparation method of liquefaction of fat wound healing functional dressings, including following step Rapid: S1: using polyvinyl alcohol biomaterial for medical purpose as raw material, production obtains sponge dressing;S2: sponge dressing is compressed, and is used Tiny structure is formed when making it in imbibition;S3: uniformly punching on sponge dressing upon compression, finally obtains liquefaction of fat wound Heal functional dressings.
Preferably, sponge dressing successively includes: supporting layer, functional layer and protective layer from outside to inside;Functional layer uses poly- second Enol foamed material and hydrogel are prepared, and form polyvinyl alcohol foam layer and hydrogel layer.
Preferably, hydrogel layer is coated on to the surrounding of the medial surface of supporting layer, polyvinyl alcohol foam layer arrangement is supporting The centre of the medial surface of layer.
Preferably, hydrogel layer is coated on the medial surface of supporting layer, and polyvinyl alcohol foam layer arrangement is in hydrogel layer The middle position of inside.
Preferably, protective layer is prepared by release paper and/or Ge Laxin paper.
Preferably, supporting layer selects polyurethane film.
Second aspect, the liquefaction of fat wound healing functional dressings being prepared using the method for the present invention.
Preferably, functional dressings provided by the invention successively include supporting layer, functional layer and protective layer, and function from outside to inside Ergosphere includes polyvinyl alcohol foam layer and hydrogel layer;Wherein, there is evenly distributed aperture, water-setting on polyvinyl alcohol foam layer Glue-line is coated on the medial surface of supporting layer, polyvinyl alcohol foam layer arrangement in the middle position of the inside of hydrogel layer, and with Through-hole is equably provided on the hydrogel layer of polyvinyl alcohol foam layer opposite position.
Technical solution provided by the invention, have it is following the utility model has the advantages that
(1) functional dressings of the present invention use polyvinyl alcohol biomaterial for medical purpose, are that a kind of absorbent is excellent, connect with human body When touching surface it is extremely soft can completely natural degradation high molecular material;Its is easy to use, can promote wound healing, special It is not to promote operation liquefaction of fat wound drainage healing.Specifically, liquefaction of fat wound healing functional dressings of the present invention can be used for Various liquefaction of fat operative incisions carry out drainage treatment by incisional wounds of the microkinetic negative pressure technique to liquefaction of fat, finally The effect of reaching quick healing of wound.
(2) present invention is using the compound polyethanol hydrogel of medical polyurethane support membrane as raw material, Pasting skinfold And pore, complete gluing, sealing make to be partially formed enclosed environment, avoid notch by extraneous infection, hydrogel adhesion week The skin for the stemness enclosed, adhesion moist wounds not will cause secondary injury and pain, and can prevent Hquid from pasting when removing Surface is applied, sepage vertically absorbs.3 layers of composite construction of compressibility special type polyvinyl alcohol biomaterial for medical purpose are recycled to form pump Effect generates local tiny structure, reaches and quickly absorb wound extravasating and Incision drain effect.The oozing of blood of energy overall absorption notch, Sepage, adsorbs liquefied fat drop etc., while moist environment is conducive to necrotic tissue and fibrinolysis, avoid notch with The residual of the component semisolids such as the solid components such as cellulose, protein between dressing in diffusate and liquoring fat is eliminated thin Growth of the microorganisms such as bacterium in notch reduces infection of incisional wound chance, reduces tissue metabolism, mitigates edema wound degree, micro- negative Pressure can expand capillary, improve microcirculation, promote granulation growth, to promote wound healing.And sepage is real when in use When suck polyvinyl alcohol foam layer, can both keep notch moist environment, have obvious analgesic activity, and can be to avoid wound extravasating Aggregation, notch can create low-oxygen environment without the incrustation phase, reduce scar proliferation.It can promote a variety of growth factor releases and raise it Activity accelerates wound healing.The application of the technology reduces dressing change frequency compared with route dressing change, when mitigating surface of a wound dressing It damages again.The pain for reducing patient simultaneously, alleviates the work load of medical staff, substantially reduces the incision in treatment time And cost, the quality of wound healing is improved, the economic cost of patient is also reduced.
(3) present invention uses polyvinyl alcohol biomaterial for medical purpose, table when being a kind of excellent absorbent and human contact Face it is extremely soft can completely natural degradation high molecular material.Its excellent absorbent not only shows faster imbibition speed In rate, it is also embodied in its superpower liquid absorbency rate.Modern surgery operation in be applied widely and become can not or Scarce critical material, the great potential in terms of liquefaction of fat notch.
Additional aspect and advantage of the invention will be set forth in part in the description, and will partially become from the following description Obviously, or practice through the invention is recognized.
Detailed description of the invention
Fig. 1 is the sectional view of the liquefaction of fat wound healing functional dressings in the embodiment of the present invention;
Fig. 2 is the structure chart of the functional layer of the liquefaction of fat wound healing functional dressings in the embodiment of the present invention;
Wherein,
1 supporting layer;2 functional layers;21 polyvinyl alcohol foam layers;22 hydrogel layers;3 protective layers.
Specific embodiment
The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end Same or similar label indicates same or similar element or element with the same or similar functions.Below with reference to attached The embodiment of figure description is exemplary, it is intended to is used to explain the present invention, and is not considered as limiting the invention.
It is illustrated With reference to embodiment:
Embodiment one
The present embodiment provides a kind of preparation methods of liquefaction of fat wound healing functional dressings, comprising the following steps:
S1: using polyvinyl alcohol biomaterial for medical purpose as raw material, production obtains sponge dressing.Wherein, sponge dressing from outside to It inside successively include: supporting layer, functional layer and protective layer;Functional layer is prepared using polyvinyl alcohol foam and hydrogel, Form polyvinyl alcohol foam layer and hydrogel layer;Hydrogel layer is coated on to the surrounding of the medial surface of supporting layer, polyvinyl alcohol bubble Foam layer is arranged in the centre of the medial surface of supporting layer.
S2: sponge dressing is compressed, for making it form tiny structure in imbibition.
S3: uniformly punching on sponge dressing upon compression, finally obtains liquefaction of fat wound healing functional dressings.
Embodiment two
The present embodiment provides a kind of liquefaction of fat wound healing functional dressings, as shown in Figure 1, comprising: be laminated from outside to inside Supporting layer 1, functional layer 2 and protective layer 3, functional layer 2 include polyvinyl alcohol foam layer 21 and hydrogel layer 22.Polyvinyl alcohol bubble There is evenly distributed aperture in foam layer 2;Supporting layer 1 is polyurethane film;Protective layer 3 is release paper or Ge Laxin paper.Wherein, water Gel layer 22 is coated on the surrounding of the medial surface of supporting layer 1, and polyvinyl alcohol foam layer 21 is arranged in the medial surface of supporting layer 1 Between namely hydrogel layer 22 centre.
Embodiment three
The present embodiment provides a kind of liquefaction of fat wound healing functional dressings, as shown in Figure 1, comprising: be laminated from outside to inside Supporting layer 1, functional layer 2 and protective layer 3, functional layer 2 include polyvinyl alcohol foam layer 21 and hydrogel layer 22.Polyvinyl alcohol bubble There is evenly distributed aperture in foam layer 2;Supporting layer 1 is polyurethane film;Protective layer 3 is release paper or Ge Laxin paper.Wherein, water Gel layer 22 is coated on the medial surface of supporting layer 1, and polyvinyl alcohol foam layer 21 is arranged in the centre of the inside of hydrogel layer 22 Position, and be equably provided with through-hole on the hydrogel layer 22 of 21 opposite position of polyvinyl alcohol foam layer.Wherein, polyethylene Alcohol froth bed 21 makes it generate " siphonic effect " and similar " pump effect " as injection needle tube in imbibition through compression processing, Tiny structure is formed, and uniformly stamps several rows of aperture in the dressing compressed, liquid can be promoted preferably to absorb.
Functional dressings of the present invention use polyvinyl alcohol biomaterial for medical purpose, are that a kind of absorbent is excellent and human contact When surface it is extremely soft can completely natural degradation high molecular material;Its is easy to use, can promote wound healing, especially It is to promote operation liquefaction of fat wound drainage healing.Specifically, liquefaction of fat wound healing functional dressings of the present invention can be used for respectively Kind liquefaction of fat operative incision carries out drainage treatment by incisional wounds of the microkinetic negative pressure technique to liquefaction of fat, finally reaches The effect of to quick healing of wound.Its excellent absorbent is not only shown on faster rate of liquid aspiration, and it is super to be also embodied in it Strong liquid absorbency rate.It is applied widely in modern surgery operation and becomes indispensable critical material, in rouge Great potential in terms of fat liquefaction notch.
The present invention utilizes the compound polyethanol hydrogel of medical polyurethane support membrane, Pasting skinfold and pore, completely Gluing, sealing makes to be partially formed enclosed environment, avoids notch by extraneous infection, the skin of the stemness around hydrogel adhesion Skin, adhesion moist wounds not will cause secondary injury and pain, and can prevent Hquid from sticking surface, sepage when removing It is vertical to absorb.It recycles compressibility special type polyvinyl alcohol biomaterial for medical purpose to form pump effect, generates local tiny structure, reach Quickly absorb wound extravasating and Incision drain effect.The oozing of blood of energy overall absorption notch, sepage, adsorb liquefied fat drop etc., Environment moist simultaneously is conducive to necrotic tissue and fibrinolysis, avoids the fiber between notch and dressing in diffusate The residual of the component semisolids such as the solid components such as element, protein and liquoring fat eliminates the tastes of the microorganisms in notch such as bacterium It is raw, infection of incisional wound chance is reduced, tissue metabolism is reduced, mitigates edema wound degree, tiny structure can expand capillary, improve Microcirculation promotes granulation growth, to promote wound healing.And sepage sucks polyvinyl alcohol foam layer in real time when in use, both Notch moist environment can be kept, has obvious analgesic activity, and can assemble to avoid wound extravasating, notch can be created without the incrustation phase Low-oxygen environment is made, scar proliferation is reduced.It can promote a variety of growth factor releases and raise its activity, accelerate wound healing.The skill The application of art reduces dressing change frequency compared with route dressing change, mitigates the damage again when surface of a wound dressing.Disease is reduced simultaneously The pain of people alleviates the work load of medical staff, substantially reduces incision in treatment time and cost, improves wound healing Quality, also reduce the economic cost of patient.
Therefore, dressing of the present invention is easy to operate, once use, can quick drainage, liquid absorption amount is big, can promote wound and is quickly cured It closes, reduces the risk of secondary pollution;And it is long-term without replacing, reduce dressing change frequency, while reducing the pain of patient, reduces The workload of medical staff.
It should be noted that unless otherwise indicated, technical term or scientific term used in this application should be this hair The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustratively, not as limitation, because This, other examples of exemplary embodiment can have different values.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations;To the greatest extent Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into Row equivalent replacement;And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme should all cover in protection scope of the present invention.

Claims (8)

1. a kind of preparation method of liquefaction of fat wound healing functional dressings, which comprises the following steps:
S1: using polyvinyl alcohol biomaterial for medical purpose as raw material, production obtains sponge dressing;
S2: the sponge dressing is compressed, for making it form tiny structure in imbibition;
S3: uniformly punching on the compressed sponge dressing, finally obtains the liquefaction of fat wound healing functional dressings.
2. the preparation method of liquefaction of fat wound healing functional dressings according to claim 1, it is characterised in that:
The sponge dressing successively includes: supporting layer, functional layer and protective layer from outside to inside;The functional layer uses polyvinyl alcohol Foamed material and hydrogel are prepared, and form polyvinyl alcohol foam layer and hydrogel layer.
3. the preparation method of liquefaction of fat wound healing functional dressings according to claim 2, it is characterised in that:
The hydrogel layer is coated on to the surrounding of the medial surface of the supporting layer, the polyvinyl alcohol foam layer arrangement is described The centre of the medial surface of supporting layer.
4. the preparation method of liquefaction of fat wound healing functional dressings according to claim 2, it is characterised in that:
The hydrogel layer is coated on the medial surface of the supporting layer, and the polyvinyl alcohol foam layer arrangement is in the hydrogel The middle position of the inside of layer.
5. according to the preparation method of the described in any item liquefaction of fat wound healing functional dressings of claim 2~4, feature exists In:
The protective layer is prepared by release paper and/or Ge Laxin paper.
6. according to the preparation method of the described in any item liquefaction of fat wound healing functional dressings of claim 2~4, feature exists In:
The supporting layer selects polyurethane film.
7. the liquefaction of fat wound healing functional dressings that any one the method is prepared according to claim 1~6.
8. liquefaction of fat wound healing functional dressings according to claim 7, it is characterised in that:
The functional dressings include successively from outside to inside supporting layer, functional layer and protective layer, and the functional layer includes polyethylene Alcohol froth bed and hydrogel layer;
Wherein, there is evenly distributed aperture, the hydrogel layer is coated on the supporting layer on the polyvinyl alcohol foam layer Medial surface on, the middle position of inside of the polyvinyl alcohol foam layer arrangement in the hydrogel layer, and with the poly- second Through-hole is equably provided on the hydrogel layer of enol froth bed opposite position.
CN201910048482.0A 2019-01-18 2019-01-18 Liquefaction of fat wound healing functional dressings and preparation method thereof Pending CN109620997A (en)

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Application Number Priority Date Filing Date Title
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104622645A (en) * 2015-01-29 2015-05-20 上海市同仁医院 Medical negative-pressure adsorption dressing and method for using medical negative-pressure adsorption dressing to heal wound surface
CN104622643A (en) * 2015-01-29 2015-05-20 上海市同仁医院 Medical negative-pressure adsorption dressing and application thereof
CN204671391U (en) * 2015-05-18 2015-09-30 广东泰宝医疗科技股份有限公司 A kind of hydrogel foam dressing
CN107652464A (en) * 2016-07-25 2018-02-02 克林纳奇(荆州)高分子科技有限公司 A kind of polyvinyl formal sponge cloth and its preparation method and application
CN108498852A (en) * 2018-04-24 2018-09-07 万绵水 Ag/SiO2The wound dressing and preparation method thereof of hydrogel composite sponge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104622645A (en) * 2015-01-29 2015-05-20 上海市同仁医院 Medical negative-pressure adsorption dressing and method for using medical negative-pressure adsorption dressing to heal wound surface
CN104622643A (en) * 2015-01-29 2015-05-20 上海市同仁医院 Medical negative-pressure adsorption dressing and application thereof
CN204671391U (en) * 2015-05-18 2015-09-30 广东泰宝医疗科技股份有限公司 A kind of hydrogel foam dressing
CN107652464A (en) * 2016-07-25 2018-02-02 克林纳奇(荆州)高分子科技有限公司 A kind of polyvinyl formal sponge cloth and its preparation method and application
CN108498852A (en) * 2018-04-24 2018-09-07 万绵水 Ag/SiO2The wound dressing and preparation method thereof of hydrogel composite sponge

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