CN109620488A - The production technology of 3D layering printing is carried out under a kind of low temperature - Google Patents
The production technology of 3D layering printing is carried out under a kind of low temperature Download PDFInfo
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- CN109620488A CN109620488A CN201811508440.2A CN201811508440A CN109620488A CN 109620488 A CN109620488 A CN 109620488A CN 201811508440 A CN201811508440 A CN 201811508440A CN 109620488 A CN109620488 A CN 109620488A
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- Prior art keywords
- low temperature
- production technology
- carrying
- bracket
- layering
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
Abstract
The invention discloses the production technologies that 3D layering printing is carried out under a kind of low temperature, the principle dripped using filtrate solvent, the mixed solution for having drug is formed, layering spraying is then carried out on bracket mould under cryogenic, the biodegradable material bracket to form drug containing is printed by multilayer.By means of the invention it is possible to guarantee the consistency of the structural strength of support product, while drug itself can be also dissolved into cradling piece, to realize the Continuous slow release effect of drug.
Description
Technical field
The present invention relates to the production technologies that 3D layering printing is carried out in a low temperature of a kind of manufacturing field for drug stent.
Background technique
Existing 3D printing is applied to the Related products such as the intracorporal bracket of people, is divided into two kinds of production models.The first be
3D printing is carried out under the condition of high temperature of raw material melting；Another kind is that progress laser is cut after degradation material is extruded into tubing
It cuts, then carries out configuration and form supporting structure.No matter which kind of mode is used, requires structure construction under the high temperature conditions, it is final complete
At sizing, according to different materials, temperature can be at 170-250 DEG C or so.This technology pattern makes the choosing of 3D printing timbering material
It is narrow with range.Biodegradable polymer material as bracket raw material in the molten state, the molecule of high molecular material
Chain is heated to be destroyed, and molecular weight and viscosity reduce, and the bracket raw material heated time of the extrusion described in different time is inconsistent,
It is easy to cause the physical property of product inconsistent, destroys the stability of supporting structure, lead to the consistency with a collection of timbering material
Poor, different batches timbering material consistency is also bad.In bracket actual clinical in use, if needing the medicine of bracket carrying treatment
Object then needs to load one layer of medicine layer in rack surface using the method for ultrasound spraying.But using ultrasonic spray method in bracket
The load capacity of the medicine layer of upper spraying, drug is smaller, and sustained drug action time is very short, can all release within the short time
It puts, the effect being sustained for a long time in human body cannot be played.
Summary of the invention
The purpose of the invention is to overcome the deficiencies of the prior art and provide the life that 3D layering printing is carried out under a kind of low temperature
Production. art, it can produce the supporting structure of stable structure under cryogenic.
Realizing a kind of technical solution of above-mentioned purpose is: the production technology of 3D layering printing is carried out under a kind of low temperature, including
Following steps:
Step 1, in organic solvent by biodegradable material dissolution, Biodegradable solutions are formed；
Step 2, Biodegradable solutions are added in drug, are then sufficiently stirred and are stood so that bubble is discharged, is formed
Stable mixed solution；
Step 3, mixed solution is added in the magazine of 3D printer, is stood to exclude bubble, then will be deposited
Material device loading is arranged in the 3D printer in cryogenic vacuum cabinet, and opens cryogenic vacuum cabinet；
Step 4, starting 3D printer sprays to mixed solution on the bracket mould of fixed shape, wherein bracket first layer
Spray time be 2-5min, then carry out duplicate spraying print job, the backing thickness of every 0.1mm prints 3-5 times；
Step 5, it after to multilayer bracket printing, takes out printed the multilayer bracket finished rapidly, be subsequently placed in cold
It is stood in lyophilizer；
Step 6, the multilayer bracket in freeze drier is taken out, is placed into convection oven and is dried.
Further, in step 1, the organic solvent includes acetone, ethyl alcohol, methylene chloride, chloroform, tetrahydro furan
It mutters, hexafluoroisopropanol or ethyl acetate.
Further, in step 2, when drug to be added Biodegradable solutions and is sufficiently stirred, to solution
Middle addition silicone oil.
Further, the viscosity that the mixed liquor of silicone oil is added is at least 2.0dl/g.
Further, in step 3, after opening cryogenic vacuum cabinet, the temperature that cryogenic vacuum cabinet maintains is 0 DEG C.
Further, in step 5, the temperature of freeze drier is set as -10 DEG C, and time of repose is 8 hours.
Further, in step 6, the temperature of convection oven is set as 40 DEG C, and drying time is 10 minutes.
The production technology that 3D layering printing is carried out under a kind of low temperature of the invention is formed using the principle that filtrate solvent drips
Then mixed solution with drug carries out layering spraying on bracket mould under cryogenic, prints to be formed by multilayer
The biodegradable material bracket of drug containing.By means of the invention it is possible to guarantee the consistency of the structural strength of support product, while
Drug itself can be dissolved into cradling piece, to realize the Continuous slow release effect of drug.
Specific embodiment
In order to preferably understand technical solution of the present invention, carried out in detail below by specifically embodiment
Illustrate:
The production technology that 3D layering printing is carried out under a kind of low temperature of the invention, needs using 3D printer and can place
The cryogenic vacuum cabinet of the 3D printer.Specifically comprise the following steps:
Step 1, in organic solvent by biodegradable material dissolution, Biodegradable solutions are formed.Solvent includes: third
Ketone, ethyl alcohol, methylene chloride, chloroform, tetrahydrofuran, hexafluoroisopropanol or ethyl acetate organic solvent.For any one
Organic solvent has corresponding degradation material solvent burden ratio.
Step 2, Biodegradable solutions are added in drug according to the ratio, is then sufficiently stirred and is stood so that gas is discharged
Bubble, forms stable mixed solution.A small amount of silicone oil can be suitably added to promote the stability of mixed solution.The mixing of silicone oil is added
The final viscosity of liquid is at least 2.0dl/g.
Step 3, mixed solution is added in the magazine of 3D printer, is stood to exclude bubble, then will be deposited
Material device loading is arranged in the 3D printer in cryogenic vacuum cabinet, and opens cryogenic vacuum cabinet, maintains temperature at 0 DEG C.In 3D
The printing of printer goes to place preset bracket mould, and bracket mould is by breathable stainless steel or polytetrafluoroethylene (PTFE) (PTFE) etc.
Material is made.
Step 4, starting 3D printer sprays to mixed solution on bracket mould, and the nozzle of 3D printer is according to different branch
The size and specification of frame, it is adjustable to go out liquid speed degree.The spray time of bracket first layer is limited to 2-5min, then carries out weight
The backing thickness of multiple spraying print job, every 0.1mm prints 3-5 times.
Step 5, it after to multilayer bracket printing, takes out printed the multilayer bracket finished rapidly, be subsequently placed in -10
DEG C freeze drier in stand 8 hours so that rack forming is fixed.
Step 6, the multilayer bracket in freeze drier is taken out, is placed into 40 DEG C of convection oven and dries 10 minutes, it is complete
At the production of bracket.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen within the scope of claims of the present invention.
Claims (7)
1. carrying out the production technology of 3D layering printing under a kind of low temperature, which comprises the steps of:
Step 1, in organic solvent by biodegradable material dissolution, Biodegradable solutions are formed；
Step 2, Biodegradable solutions are added in drug, are then sufficiently stirred and are stood so that bubble is discharged, is formed and stablized
Mixed solution；
Step 3, mixed solution is added in the magazine of 3D printer, is stood to exclude bubble, then fills material stock
It sets loading to be arranged in the 3D printer in cryogenic vacuum cabinet, and opens cryogenic vacuum cabinet；
Step 4, starting 3D printer sprays to mixed solution on the bracket mould of fixed shape, the wherein spray of bracket first layer
The painting time is 2-5min, then carries out duplicate spraying print job, and the backing thickness of every 0.1mm prints 3-5 times；
Step 5, it after to multilayer bracket printing, takes out printed the multilayer bracket finished rapidly, it is dry to be subsequently placed in freezing
It is stood in dry machine；
Step 6, the multilayer bracket in freeze drier is taken out, is placed into convection oven and is dried.
2. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 1, which is characterized in that step 1
In, the organic solvent includes acetone, ethyl alcohol, methylene chloride, chloroform, tetrahydrofuran, hexafluoroisopropanol or acetic acid second
Ester.
3. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 1, which is characterized in that step 2
In, when drug to be added Biodegradable solutions and is sufficiently stirred, silicone oil is added into solution.
4. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 3, which is characterized in that silicon is added
The viscosity of the mixed liquor of oil is at least 2.0dl/g.
5. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 1, which is characterized in that step 3
In, after opening cryogenic vacuum cabinet, the temperature that cryogenic vacuum cabinet maintains is 0 DEG C.
6. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 1, which is characterized in that step 5
In, the temperature of freeze drier is set as -10 DEG C, and time of repose is 8 hours.
7. carrying out the production technology of 3D layering printing under a kind of low temperature according to claim 1, which is characterized in that step 6
In, the temperature of convection oven is set as 40 DEG C, and drying time is 10 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811508440.2A CN109620488A (en) | 2018-12-11 | 2018-12-11 | The production technology of 3D layering printing is carried out under a kind of low temperature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811508440.2A CN109620488A (en) | 2018-12-11 | 2018-12-11 | The production technology of 3D layering printing is carried out under a kind of low temperature |
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| Publication Number | Publication Date |
|---|---|
| CN109620488A true CN109620488A (en) | 2019-04-16 |
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| CN201811508440.2A Pending CN109620488A (en) | 2018-12-11 | 2018-12-11 | The production technology of 3D layering printing is carried out under a kind of low temperature |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623737A (en) * | 2014-12-31 | 2015-05-20 | 深圳清华大学研究院 | Personalized tissue repairing scaffold capable of realizing pulsed sustained release and preparation method thereof |
| CN106730032A (en) * | 2016-11-15 | 2017-05-31 | 王翀 | A kind of printed material, the preparation method of tissue engineering bracket and tissue engineering bracket |
| CN107485731A (en) * | 2017-07-28 | 2017-12-19 | 上海理工大学 | Three layers of compound rest of integration and preparation method of a kind of articular cartilage reparation |
| CN107496994A (en) * | 2017-09-19 | 2017-12-22 | 云智前沿科技发展（深圳）有限公司 | A kind of postoperative medicine slow release stent based on 3D printing and preparation method thereof |
| CN107754012A (en) * | 2017-11-28 | 2018-03-06 | 上海纳米技术及应用国家工程研究中心有限公司 | Method that 3D printing technique prepares PLGA/PCL/nHA composite bone repair porous scaffolds and products thereof and application |
| CN107875443A (en) * | 2017-08-04 | 2018-04-06 | 深圳市第二人民医院 | Two-phase magnetic Nano compound support frame material and preparation method thereof |
| US20180111337A1 (en) * | 2016-10-25 | 2018-04-26 | Stratasys, Inc. | Water dispersible polymer composition for use in 3d printer |
| CN108299798A (en) * | 2018-01-26 | 2018-07-20 | 成都新柯力化工科技有限公司 | A kind of 3D room temperature printing pastes and preparation method thereof |
| CN108727709A (en) * | 2018-04-11 | 2018-11-02 | 杭州科技职业技术学院 | A kind of preparation method of 3D printing soft material |
-
2018
- 2018-12-11 CN CN201811508440.2A patent/CN109620488A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623737A (en) * | 2014-12-31 | 2015-05-20 | 深圳清华大学研究院 | Personalized tissue repairing scaffold capable of realizing pulsed sustained release and preparation method thereof |
| US20180111337A1 (en) * | 2016-10-25 | 2018-04-26 | Stratasys, Inc. | Water dispersible polymer composition for use in 3d printer |
| CN106730032A (en) * | 2016-11-15 | 2017-05-31 | 王翀 | A kind of printed material, the preparation method of tissue engineering bracket and tissue engineering bracket |
| CN107485731A (en) * | 2017-07-28 | 2017-12-19 | 上海理工大学 | Three layers of compound rest of integration and preparation method of a kind of articular cartilage reparation |
| CN107875443A (en) * | 2017-08-04 | 2018-04-06 | 深圳市第二人民医院 | Two-phase magnetic Nano compound support frame material and preparation method thereof |
| CN107496994A (en) * | 2017-09-19 | 2017-12-22 | 云智前沿科技发展（深圳）有限公司 | A kind of postoperative medicine slow release stent based on 3D printing and preparation method thereof |
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| CN108299798A (en) * | 2018-01-26 | 2018-07-20 | 成都新柯力化工科技有限公司 | A kind of 3D room temperature printing pastes and preparation method thereof |
| CN108727709A (en) * | 2018-04-11 | 2018-11-02 | 杭州科技职业技术学院 | A kind of preparation method of 3D printing soft material |
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