CN109613717A - Contact lens - Google Patents
Contact lens Download PDFInfo
- Publication number
- CN109613717A CN109613717A CN201910063306.4A CN201910063306A CN109613717A CN 109613717 A CN109613717 A CN 109613717A CN 201910063306 A CN201910063306 A CN 201910063306A CN 109613717 A CN109613717 A CN 109613717A
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- China
- Prior art keywords
- contact lens
- liquid crystal
- material layer
- change
- function
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C11/00—Non-optical adjuncts; Attachment thereof
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/10—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses
- G02C7/101—Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses having an electro-optical light valve
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Health & Medical Sciences (AREA)
- Eye Examination Apparatus (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of contact lens for being able to reflect the variations such as tear osmotic pressure, it has the function cell being made of transparent permeable film, permeable film can supply water and penetrate through, function is small indoor filled with liquid crystal state material layer, liquid crystal state material layer is the material layer that a kind of variation of molecular concentration causes molecularly oriented to change, its refractive index can change according to the small indoor change of moisture content of function, and then be able to carry out different color instructions.When tear layer and/or corneal osmosis buckling, the small indoor water of the function of contact lens can be penetrated, and water content is caused to change, and then cause the variation of liquid crystal state material layer concentration, as its molecularly oriented changes, change to the refraction action of light, and then cause color change.And then wearer can a situation arises according to the generation and other related diseases that the variation of color change or entire Corneal Contact lens transmission knows itself eye tear.
Description
Technical field
The present invention relates to medical appliance fields, more particularly, to a kind of contact lens.
Background technique
Eyes are an important windows for observing health states, and are covered in the tear film of ocular, can maintain cornea, knot
Film health and eyesight it is steady and audible.Various eyes topically or systemically disease all may cause the matter, amount, composition of lacrimal secretion at
Divide or the appearance such as physicochemical property are abnormal, this kind of disease includes: the eyes such as ocular chronic inflammation, eyeball exposure, thyroid-associated ophthalmopathy
Portion's disease and abnormal thyroid function, diabetes, whole body autoimmune disease such as repair Gram disease, rheumatoid arthritis,
Erythematosus lupus etc.；Invasive disease such as lymthoma etc.；Infectious diseases；Neurological disorders；Endocrine disorder such as male sex hormone
Hyposecretion etc..The hypertonicity of tear is considered as causing the core engine of ocular inflammation, impaired, symptom and dry eyes initial symptoms
System.Clinically, the tear film permeability of any one eye all shows that there may be dry eye states equal to or higher than 308mOsm/L.
In addition, it is considered as the unstable sign of tear film that the hypertonic sex differernce of eyes tear film, which is greater than 8mOsm/L,.Therefore, the infiltration of tear is paid close attention to
The variation of the physicochemical properties such as pressure is for treatment condition monitoring and the early diagnosis of a variety of diseases and treatment effect in relation to eye disease thoroughly
Fruit monitoring, evaluation etc. have great importance.
Summary of the invention
Based on this, it is necessary to provide a kind of contact lens for being able to reflect the variations such as tear osmotic pressure.
A kind of contact lens has the function cell being made of transparent permeable film, the permeable film energy
Enough supply water penetrates through, and the function is small indoor filled with liquid crystal state material layer, and the refractive index of the liquid crystal state material layer can
Changed according to the small indoor change of moisture content of the function, and then is able to carry out different color instructions.
The liquid crystal state material layer is lyotropic liquid crystal layer in one of the embodiments,.
The liquid crystal state material layer is that tetradecyltrimethylammonium bromide aqueous solution, shell are poly- in one of the embodiments,
At least one of sugar aqueous solution and xanthan gum solution aqueous layer.
In one of the embodiments, the contact lens be used for and the surface of Corneal Contact shape and the angle
The shape of the corresponding portion of film is adapted so that the contact lens can be bonded completely with the cornea.
In one of the embodiments, the contact lens for being in oval sheet with the surface of Corneal Contact, it is horizontal
Diameter 10.5mm~15mm, vertical diameter 8.5mm~14mm.
The function cell in the contact lens can cover the entire angle in one of the embodiments,
Film.
The function cell in the contact lens is annularly distributed in one of the embodiments, it is cricoid in
The heart is used for the central optical zone corresponding to the cornea.
The diameter of the inner ring of the function cell of annular distribution is 4.8mm~5.2mm in one of the embodiments,.
The thickness of the transparent permeable film is 0.1mm~3.5mm in one of the embodiments,.
The light transmittance of the transparent permeable film is not less than 40% in one of the embodiments,.
Tear layer ecto-entad is followed successively by lipid layer, aqueous layer and slime layer, wherein again with aqueous layer ratio highest.Work as tear
Liquid is insufficient, when disease or part systemic disease etc., which occur, for eye causes the composition of tear and secretory volume to change, tear
The osmotic pressure of aqueous layer and slime layer in layer will change.And cornea is in horizontal oval sheet, without blood vessel, nutrition supplying
To such as oxygen, glucose, amino acid etc., the scattering and permeating from the liquid (tear, aqueous humor etc.) of surrounding is depended on.Therefore,
Aqueous layer and slime layer isosmoticity in tear layer, which change, will affect the nutrition supply of cornea.
The present invention has devised a kind of contact lens, has the function cell being made of transparent permeable film,
Permeable film can supply water and penetrate through, and function is small indoor filled with liquid crystal state material layer, and liquid crystal state material layer is a kind of point
The variation of sub- concentration cause molecularly oriented change material layer, refractive index can according to the small indoor change of moisture content of function and
Variation, and then it is able to carry out different color instructions.When tear layer and/or corneal osmosis buckling, the function of contact lens
The small indoor water of energy can penetrate, and cause water content to change, and then cause the variation of liquid crystal state material layer concentration, with it
Molecularly oriented variation, changes to the refraction action of light, and then cause color change.
Therefore, contact lens of the invention at least has the following beneficial effects:
1) traditional long periods of wear contact lens easily leads to a variety of eye diseases such as xerophthalmia, and cornea of the invention connects
Touching mirror can remind wearer to pass through after tear is lower than a certain concentration and the methods of artificial tears be added dropwise, blinks, remove contact lense,
Avoid the generation of xerophthalmia etc.；
2) contact lens of the invention can be used for the detection of a variety of systemic diseases, for example, diabetes blood glucose is excessively high
The raising that will lead to tear osmotic pressure afterwards causes the color change of function cell, Patients' rights blood glucose is reminded, without being answered
Miscellaneous blood sugar test.
The contact lens is conducive to diagnose wearer's eye disease as early as possible, simultaneously can be used for the real-time of systemic disease
Monitoring.
Detailed description of the invention
Fig. 1 is the side view of the contact lens of one embodiment of the invention；
Fig. 2 is the front view of contact lens shown in Fig. 1；
Fig. 3 is the structural schematic diagram of the contact lens of other embodiments of the invention.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
It should be noted that be referred to as " being set to " another element when element, it can directly on the other element or
There may also be elements placed in the middle by person.When an element is considered as " connection " another element, it can be directly to
Another element may be simultaneously present centering elements.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
As depicted in figs. 1 and 2, one embodiment of the invention provides a kind of contact lens 10, has by transparent infiltration
The function cell (not indicated in figure) that permeability film 11 is constituted.Permeable film 11 can supply water and penetrate through.The small interior of function
Filled with liquid crystal state material layer 12.The refractive index of liquid crystal state material layer 12 can become according to the small indoor change of moisture content of function
Change, and then is able to carry out different color instructions.
Permeable film 11 is microporosity film, and hydrone can pass through its micropore.In a specific example, thoroughly
The thickness of bright permeable film 11 is 0.1mm~3.5mm, such as can be 0.1mm, 0.3mm, 0.5mm, 0.8mm, 1.0mm,
1.2mm, 1.5mm, 1.8mm, 2.0mm, 2.4mm, 2.5mm, 2.8mm, 3.0mm, 3.2mm, 3.5mm etc..Permeable film 11
Light transmittance requirement is not less than 40%, to guarantee not influencing the normal vision of wearer.
Liquid crystal state material layer 12 can carry out different color instructions according to its solute concentration difference.Specifically, show at one
In example, liquid crystal state material layer 12 is lyotropic liquid crystal layer.Lysotropic liquid crystal is that a kind of variation of molecular concentration causes molecularly oriented to change,
And then the substance with liquid crystal state changes to the refraction action of light, and then color is caused to become as its molecularly oriented changes
Change.
In a more specific example, liquid crystal state material layer 12 is that tetradecyltrimethylammonium bromide aqueous solution, shell are poly-
It is water-soluble such as to can be tetradecyltrimethylammonium bromide at least one of sugar aqueous solution and xanthan gum solution aqueous layer
Liquid, chitosan aqueous solution or xanthan gum solution are also possible to tetradecyltrimethylammonium bromide aqueous solution, chitosan aqueous solution
And in xanthan gum solution two or three of aqueous solution mixture.
Contact lens 10 is used to be adapted with the shape on the surface of Corneal Contact with the shape of the corresponding portion of cornea
So that contact lens 10 can be bonded completely with cornea.In a specific example, contact lens 10 be used for and angle
The surface of film contact is in oval sheet, and transverse diameter is 10.5mm~15mm, vertical diameter 8.5mm~14mm.Preferably, entire cornea connects
The shape for touching mirror 10 is all oval sheet.
In Fig. 1 and specific example shown in Fig. 2, the function cell of contact lens 10 can cover entire cornea, can
It is mainly used for dry eyes, the eye diseases patient such as ocular chronic inflammation.
In other embodiments, as shown in figure 3, the function cell in contact lens 20 is annularly distributed, it is cricoid in
The heart 23 is used for the central optical zone corresponding to cornea, and the permeable film 21 with function cell is set around 23 cyclization of center
It sets.The diameter of the inner ring (namely center 23) of the function cell of annular distribution is 4.8mm~5.2mm, preferably 5.0mm.It is this
The contact lens 20 of structure may be used primarily for blood sugar monitoring, systemic disease monitoring etc. or for U.S. pupil.
Following present two specific examples, with to contact lens of the invention structure and function carry out it is further
Detailed description.
Example 1
Contact lens is the structure of all standing cornea, the xanthan that the small indoor addition mass percentage concentration of function is 2%
Glue solution.After wearer faces computer or mobile phone for a long time, number of winks is reduced, and tear is reduced, and it is dry and astringent to will lead to eye, function
The small indoor moisture of energy can be lost through permeable film.When the concentration of xanthan gum reaches 3% critical concentration, color occurs
Variation, translucency reduce, and wearer is reminded to supplement artificial tears.
Example 2
5mm outside the central optical zone of the function cell covering cornea of contact lens, the small interior of function is packaged with quality hundred
Dividing concentration is 4% chitosan aqueous solution.After diabetes volunteer wears, after dining, blood sugar concentration is improved, the small interior of function
Moisture enter tear under the action of osmotic pressure, cause function cell color change, remind Patients' rights blood glucose, without into
The complicated blood sugar test of row.After volunteer feeds hypoglycemic medicine about 1h, function cell color is restored for this variation.
The contact lens that the present invention designs has the function cell being made of transparent permeable film, infiltration
Property film can supply water and penetrate through, function it is small it is indoor be filled with liquid crystal state material layer, liquid crystal state material layer is that a kind of molecule is dense
The material layer that the variation of degree causes molecularly oriented to change, refractive index can become according to the small indoor change of moisture content of function
Change, and then is able to carry out different color instructions.When tear layer and/or corneal osmosis buckling, the function of contact lens
Small indoor water can penetrate, and water content is caused to change, and then cause the variation of liquid crystal state material layer concentration, with its point
Sub- change in orientation changes to the refraction action of light, causes color change, and then wearer can be according to color change or whole
A situation arises for generation that the variation of a Corneal Contact lens transmission knows itself eye tear and other related diseases.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of contact lens, which is characterized in that have the function cell being made of transparent permeable film, the infiltration
Property film can supply water and penetrate through, the function is small indoor to be filled with liquid crystal state material layer, the folding of the liquid crystal state material layer
The rate of penetrating can change according to the small indoor change of moisture content of the function, and then be able to carry out different color instructions.
2. contact lens as described in claim 1, which is characterized in that the liquid crystal state material layer is lyotropic liquid crystal layer.
3. contact lens as claimed in claim 2, which is characterized in that the liquid crystal state material layer is tetradecyltrimethylammonium
At least one of bromination aqueous ammonium, chitosan aqueous solution and xanthan gum solution aqueous layer.
4. contact lens according to any one of claims 1 to 3, which is characterized in that the contact lens is used for
It is adapted with the shape on the surface of Corneal Contact with the shape of the corresponding portion of the cornea so that the contact lens can
It is bonded completely with the cornea.
5. contact lens as claimed in claim 4, which is characterized in that the contact lens is used for and Corneal Contact
Surface is in oval sheet, transverse diameter 10.5mm~15mm, vertical diameter 8.5mm~14mm.
6. contact lens as claimed in claim 4, which is characterized in that the function cell energy in the contact lens
It is enough to cover the entire cornea.
7. contact lens as claimed in claim 4, which is characterized in that the function cell in the contact lens is in
Annular distribution, cricoid center are used for the central optical zone corresponding to the cornea.
8. contact lens as claimed in claim 7, which is characterized in that the inner ring of the function cell of annular distribution it is straight
Diameter is 4.8mm~5.2mm.
9. the contact lens as described in any one of claims 1 to 3 and 5~8, which is characterized in that the transparent infiltration
The thickness of property film is 0.1mm~3.5mm.
10. the contact lens as described in any one of claims 1 to 3 and 5~8, which is characterized in that the transparent infiltration
Property film light transmittance be not less than 40%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910063306.4A CN109613717A (en) | 2019-01-23 | 2019-01-23 | Contact lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910063306.4A CN109613717A (en) | 2019-01-23 | 2019-01-23 | Contact lens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109613717A true CN109613717A (en) | 2019-04-12 |
Family
ID=66018256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910063306.4A Pending CN109613717A (en) | 2019-01-23 | 2019-01-23 | Contact lens |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109613717A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596013A (en) * | 2009-09-18 | 2012-07-18 | 阿克伦大学 | Optical device and method for non-invasive real-time testing of blood sugar levels |
| CN105209962A (en) * | 2013-05-21 | 2015-12-30 | 庄臣及庄臣视力保护公司 | An ophthalmic lens with a passive event-based coloration system |
| CN105917270A (en) * | 2013-11-15 | 2016-08-31 | 视觉力学有限责任公司 | Contact lens with a hydrophilic layer |
| CN105934194A (en) * | 2013-12-16 | 2016-09-07 | 威里利生命科学有限责任公司 | Contact lens for measuring intraocular pressure |
| WO2017116350A1 (en) * | 2015-12-30 | 2017-07-06 | Dokuz Eylul Universitesi Rektorlugu | A contact lens design sensing tear glucose level |
| CN108578059A (en) * | 2018-05-30 | 2018-09-28 | 清华大学深圳研究生院 | A kind of contact lens of controlled drug sustained release |
| CN209265104U (en) * | 2019-01-23 | 2019-08-16 | 中山大学附属第一医院 | Contact lens |
-
2019
- 2019-01-23 CN CN201910063306.4A patent/CN109613717A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102596013A (en) * | 2009-09-18 | 2012-07-18 | 阿克伦大学 | Optical device and method for non-invasive real-time testing of blood sugar levels |
| CN105209962A (en) * | 2013-05-21 | 2015-12-30 | 庄臣及庄臣视力保护公司 | An ophthalmic lens with a passive event-based coloration system |
| CN105917270A (en) * | 2013-11-15 | 2016-08-31 | 视觉力学有限责任公司 | Contact lens with a hydrophilic layer |
| CN105934194A (en) * | 2013-12-16 | 2016-09-07 | 威里利生命科学有限责任公司 | Contact lens for measuring intraocular pressure |
| WO2017116350A1 (en) * | 2015-12-30 | 2017-07-06 | Dokuz Eylul Universitesi Rektorlugu | A contact lens design sensing tear glucose level |
| CN108578059A (en) * | 2018-05-30 | 2018-09-28 | 清华大学深圳研究生院 | A kind of contact lens of controlled drug sustained release |
| CN209265104U (en) * | 2019-01-23 | 2019-08-16 | 中山大学附属第一医院 | Contact lens |
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